Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.25361
S. Dwiningsih, Samsulhadi Samsulhadi, Arif Tunjungseto, Monika Lijuwardi, Arsana Wiyasa
Introduction: Earlier menopause has been associated with increased risk of cardiovascular disease, osteoporosis, shorter life expectancy and even cognitive decline. There are many factors that cause differences in the age of menopause in women, one of these environmental factors is a history of night shift work as a consequence of a job. It is not yet known whether female medical workers, with a history of night shifts, get earlier menopause.Methods: This case control study was conducted among 57 female night workers of the Dr. Soetomo General Academic Hospital. Data collection was conducted from December 2019 - March 2020. The study sample was postmenopausal health workers (nurse and midwife) and administrators. The instrument used in this study was a list of interview questions. The data was processed using SPSS software release 23.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.
{"title":"Night Shift Work Accelerates Menopausal Age in Health Workers","authors":"S. Dwiningsih, Samsulhadi Samsulhadi, Arif Tunjungseto, Monika Lijuwardi, Arsana Wiyasa","doi":"10.20473/bhsj.v4i1.25361","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.25361","url":null,"abstract":"Introduction: Earlier menopause has been associated with increased risk of cardiovascular disease, osteoporosis, shorter life expectancy and even cognitive decline. There are many factors that cause differences in the age of menopause in women, one of these environmental factors is a history of night shift work as a consequence of a job. It is not yet known whether female medical workers, with a history of night shifts, get earlier menopause.Methods: This case control study was conducted among 57 female night workers of the Dr. Soetomo General Academic Hospital. Data collection was conducted from December 2019 - March 2020. The study sample was postmenopausal health workers (nurse and midwife) and administrators. The instrument used in this study was a list of interview questions. The data was processed using SPSS software release 23.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes. ","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84827431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.20473/bhsj.v3i2.22141
Nihal Sofyan, I Ketut Sudiana, B. Askandar
Introduction: Endometrial cancer is a malignant tumor of primary endometrial epithelium that placed as the sixth most common cancer in women worldwide. The exact cause of it is still unknown although there are several risk factors has been well studied and the incidence rate is increasing every year. The aim of the study is to describe the profile of endometrial cancer patients in third referral hospital in Surabaya based on known risk factors.Methods: We collected data retrospectively through the medical record of outpatients with endometrial cancer diagnosis from January-December 2016. A total of 120 patients were collected and only 95 patients who meet the inclusion criteria. Data about age, age of menarche, status of menopause, parity, Body Mass Index (BMI), history of disease, and family history of cancer were extracted then presented descriptively.Results: From 95 patients, the largest distribution were age 51-60 years old (47,37%), and was diagnosed mostly in women with parity ≤2 (47,37%), postmenopausal status (61,05%), age of menarche ≥ 12 (85,26%), and normal weight (35,79%). Most of patients didn’t have either any history of disease (57,89%) or family history of cancer (89,47%).Conclusion: Most of the endometrial cancer patients in Dr. Soetomo General hospital Surabaya were women aged 51-60 years old with postmenopausal status, age of menarche ≥ 12 years old, number of parities ≤2, and normal weight. The majority of them were also found to have no history of disease and family history of cancer.
{"title":"Profile of Endometrial Cancer Patients in the Third Referral Hospital in Surabaya based on Known Risk Factors","authors":"Nihal Sofyan, I Ketut Sudiana, B. Askandar","doi":"10.20473/bhsj.v3i2.22141","DOIUrl":"https://doi.org/10.20473/bhsj.v3i2.22141","url":null,"abstract":"Introduction: Endometrial cancer is a malignant tumor of primary endometrial epithelium that placed as the sixth most common cancer in women worldwide. The exact cause of it is still unknown although there are several risk factors has been well studied and the incidence rate is increasing every year. The aim of the study is to describe the profile of endometrial cancer patients in third referral hospital in Surabaya based on known risk factors.Methods: We collected data retrospectively through the medical record of outpatients with endometrial cancer diagnosis from January-December 2016. A total of 120 patients were collected and only 95 patients who meet the inclusion criteria. Data about age, age of menarche, status of menopause, parity, Body Mass Index (BMI), history of disease, and family history of cancer were extracted then presented descriptively.Results: From 95 patients, the largest distribution were age 51-60 years old (47,37%), and was diagnosed mostly in women with parity ≤2 (47,37%), postmenopausal status (61,05%), age of menarche ≥ 12 (85,26%), and normal weight (35,79%). Most of patients didn’t have either any history of disease (57,89%) or family history of cancer (89,47%).Conclusion: Most of the endometrial cancer patients in Dr. Soetomo General hospital Surabaya were women aged 51-60 years old with postmenopausal status, age of menarche ≥ 12 years old, number of parities ≤2, and normal weight. The majority of them were also found to have no history of disease and family history of cancer.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84476926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-30DOI: 10.20473/bhsj.v3i2.22140
Adam Surya Romadhon, Joni Susanto, R. Loebis
Introduction: Congenital cataract is turbidity occurs in eye lens that present at birth or immediately after. We aim to find out visual acuity after congenital surgery between children under 2 years old and 2-17 years old after following up 3, 6, 12 months.Methods: This was a cross-sectional study. Data were gathered from medical record of congenital cataract aged ≤2 years and >2-17 years including age of surgery, frequency of eyes, sex, laterality, and visual acuity of patients with best corrected visual acuity (BCVA). All data analyzed using Mann-Whitney test.Results: 41 children (67 affected eyes) in which 45 eyes that were operated at aged ≤2 years and 22 eyes were operated at aged >2-17 years. There was average difference of visual acuity between age group of ≤2 years and >2-17 years while following-up 3 months (1.60 ± 0.34 logMAR, 1.23 ± 0.67 logMAR, p = 0,003). Whereas in follow up 6 months (1.23 ± 0.47 logMAR, 1.15 ± 0.68 logMAR, p = 0,242) and 12 months (0.94 ± 0.47 logMAR, 0.96 ± 0.44 logMAR, p = 0,840), there were no difference significant average of visual acuity.Conclusion: Visual acuity after following-up 3 and 6 months in age group of >2-17 years were better than age group of ≤2 years, whereas after following-up 12 months in age group ≤2 years, it was obtained that visual acuity was better than age group of >2-17 years.
简介:先天性白内障是在出生时或出生后立即出现的晶状体混浊。我们的目的是在随访3、6、12个月后，找出2岁以下和2-17岁儿童先天性手术后的视力。方法:采用横断面研究。收集年龄≤2岁和>2-17岁先天性白内障患者的病历资料，包括最佳矫正视力(BCVA)患者的手术年龄、眼频率、性别、侧边性和视力。所有数据采用Mann-Whitney检验分析。结果:41例患儿67只眼，其中年龄≤2岁手术45只眼，>2-17岁手术22只眼。随访3个月时，≤2岁和>2-17岁年龄组的平均视力差异为(1.60±0.34)logMAR，(1.23±0.67)logMAR, p = 0.003。随访6个月(1.23±0.47 logMAR, 1.15±0.68 logMAR, p = 0,242)和12个月(0.94±0.47 logMAR, 0.96±0.44 logMAR, p = 0,840)，两组平均视力无显著差异。结论:>2-17岁组随访3、6个月后视力优于≤2岁组，≤2岁组随访12个月后视力优于>2-17岁组。
{"title":"The Comparison of Visual Acuity After Congenital Cataract Surgery between Children ≤2 Years and >2-17 Years","authors":"Adam Surya Romadhon, Joni Susanto, R. Loebis","doi":"10.20473/bhsj.v3i2.22140","DOIUrl":"https://doi.org/10.20473/bhsj.v3i2.22140","url":null,"abstract":"Introduction: Congenital cataract is turbidity occurs in eye lens that present at birth or immediately after. We aim to find out visual acuity after congenital surgery between children under 2 years old and 2-17 years old after following up 3, 6, 12 months.Methods: This was a cross-sectional study. Data were gathered from medical record of congenital cataract aged ≤2 years and >2-17 years including age of surgery, frequency of eyes, sex, laterality, and visual acuity of patients with best corrected visual acuity (BCVA). All data analyzed using Mann-Whitney test.Results: 41 children (67 affected eyes) in which 45 eyes that were operated at aged ≤2 years and 22 eyes were operated at aged >2-17 years. There was average difference of visual acuity between age group of ≤2 years and >2-17 years while following-up 3 months (1.60 ± 0.34 logMAR, 1.23 ± 0.67 logMAR, p = 0,003). Whereas in follow up 6 months (1.23 ± 0.47 logMAR, 1.15 ± 0.68 logMAR, p = 0,242) and 12 months (0.94 ± 0.47 logMAR, 0.96 ± 0.44 logMAR, p = 0,840), there were no difference significant average of visual acuity.Conclusion: Visual acuity after following-up 3 and 6 months in age group of >2-17 years were better than age group of ≤2 years, whereas after following-up 12 months in age group ≤2 years, it was obtained that visual acuity was better than age group of >2-17 years.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76034731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-12DOI: 10.20473/bhsj.v3i1.19089
Mardliyana Shalihah, B. Utomo, S. Yotopranoto, H. Arwati
Introduction: Mosquito-borne diseases are still a burden worldwide, including in Indonesia. Some of those diseases, such as filariasis and Japanese encephalitis, are transmitted by some species of Culex mosquitoes. We aimed to describe the fauna of Culex mosquitoes in Salamwates village, Dongko subdistrict, Trenggalek district. Methods: Female Culex mosquitoes were collected in Salamwates village at night using the methods of indoor human-baited double bed-net trap and outdoor cow-baited double bed-net trap. The spesies of collected Culex mosquitoes were identified based on identification guide published by Ministry of Health of Republic Indonesia. Results: There were 67 identifiable female mosquitoes collected using cow-baited methods and no female mosquitoes collected using human-baited methods. Those mosquitoes consisted of nine species. Culex tritaeniorhynchus (29.85%), C. gelidus (23.88%), C. vishnui (13.43%), C. pseudovishnui (11.94%) were the dominant species. The peaks of biting activities were at 18.45-19.00 and 23.45-24.00. Conclusion: Nine species of Culex mosquitoes collected using cow-baited methods. C. tritaeniorhynchus was the dominant species. Those mosquitoes were zoophilic and exophagic. The peaks of biting activities of the Culex mosquitoes were at dusk and midnight.
{"title":"Fauna of Culex Mosquitoes In Salamwates Village Dongko Subdistrict, Trenggalek City","authors":"Mardliyana Shalihah, B. Utomo, S. Yotopranoto, H. Arwati","doi":"10.20473/bhsj.v3i1.19089","DOIUrl":"https://doi.org/10.20473/bhsj.v3i1.19089","url":null,"abstract":"Introduction: Mosquito-borne diseases are still a burden worldwide, including in Indonesia. Some of those diseases, such as filariasis and Japanese encephalitis, are transmitted by some species of Culex mosquitoes. We aimed to describe the fauna of Culex mosquitoes in Salamwates village, Dongko subdistrict, Trenggalek district. Methods: Female Culex mosquitoes were collected in Salamwates village at night using the methods of indoor human-baited double bed-net trap and outdoor cow-baited double bed-net trap. The spesies of collected Culex mosquitoes were identified based on identification guide published by Ministry of Health of Republic Indonesia. Results: There were 67 identifiable female mosquitoes collected using cow-baited methods and no female mosquitoes collected using human-baited methods. Those mosquitoes consisted of nine species. Culex tritaeniorhynchus (29.85%), C. gelidus (23.88%), C. vishnui (13.43%), C. pseudovishnui (11.94%) were the dominant species. The peaks of biting activities were at 18.45-19.00 and 23.45-24.00. Conclusion: Nine species of Culex mosquitoes collected using cow-baited methods. C. tritaeniorhynchus was the dominant species. Those mosquitoes were zoophilic and exophagic. The peaks of biting activities of the Culex mosquitoes were at dusk and midnight.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85769891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-12DOI: 10.20473/bhsj.v3i1.17994
N. Rahmianti, T. Yusrizal, M. Al-Farabi
Coronary artery disease (CAD) becomes primary disease causing morbidity and mortality in developed country. Chronic CAD disease progress over years or decades and becomes a significant health burden worldwide. Most CAD cases occur in individuals with at least one risk factor. Thus, risk modification and regular exercise are part of coronary artery disease management to reduce disease progression. Regular exercise training is an intense technique to expand the threshold of angina-free activity levels in stable disease conditions when symptomatic CAD has developed. This review will explain the current updates in the risk management and exercise that can be used to improve patients’ quality of life and reduce the severity progression of the disease.
{"title":"Current Update on the Risk Factor Modification and Excercise Following Coronary Artery Disease","authors":"N. Rahmianti, T. Yusrizal, M. Al-Farabi","doi":"10.20473/bhsj.v3i1.17994","DOIUrl":"https://doi.org/10.20473/bhsj.v3i1.17994","url":null,"abstract":"Coronary artery disease (CAD) becomes primary disease causing morbidity and mortality in developed country. Chronic CAD disease progress over years or decades and becomes a significant health burden worldwide. Most CAD cases occur in individuals with at least one risk factor. Thus, risk modification and regular exercise are part of coronary artery disease management to reduce disease progression. Regular exercise training is an intense technique to expand the threshold of angina-free activity levels in stable disease conditions when symptomatic CAD has developed. This review will explain the current updates in the risk management and exercise that can be used to improve patients’ quality of life and reduce the severity progression of the disease. ","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77875511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-31DOI: 10.20473/bhsj.v2i2.14956
Alexander Tikara Sugondo, Deasy Ardiany, Djohar Nuswantoro, Pulus Budiono Notopuro
Introduction: Diabetes mellitus is a non-transmitted pandemic disease which had spreaded on a global scale. The prevalence of diabetes mellitus in the world according to the International Diabetes Federation (IDF) is 1.9% and diabetes mellitus is ranked seventh as the cause of death in the world, around 95% in the world is type 2 diabetes mellitus. According to Riset Kesehatan Dasar (Riskesdas) in 2013, the prevalence of diabetes mellitus in Indonesia is 6,9%. Type 2 diabetes mellitus that is not well controlled will increase the risk of chronic complications, both microangiopathies such as nephropathy, and macroangiopathy such as hypertension. The aim of the study was to determine correlation between HbA1c levels with eGFR (Estimated Glomerulus Filtration Rate) and blood pressure (systolic and diastolic).Methods: An analytic observational cross-sectional study, collecting the data from 94 patients with type 2 diabetes mellitus, Dr. Soetomo General Hospital, Surabaya, from January to May 2018. The variables were collected from patient’s medical records. Analysis using Spearman’s Rank Correlation test. To determine normality of the data, we use Kolmogorov-smirnov test.Results: The results showed that there are 134 (57,8%) patients with type 2 diabetes mellitus are female more than male. Patients with greater than or equal to 45 years old were 203 (87,5%) patients, more than under 45 years old. The correlation test showed that there was no significant correlation between HbA1c and systolic blood pressure (r=-0,127; p=0,054). Also there was no significant correlation between HbA1c and diastolic blood pressure (r=-0,111; p=0,093). Analysis on other factor showed a significant correlation between HbA1c and eGFR (r=0.341; p=0.000).Conclusion: There was no significant correlation between HbA1c and systolic blood pressure, also there was no significant correlation between HbA1c and diastolic blood pressure. But, there was a significant correlation between HbA1c and eGFR. This is because the data retrieval does not consider the drug consumption and therapy that has been done by the patient, as well as examination of HbA1c, serum creatinine eGFR, and blood pressure not at the same time.
{"title":"Relationship between HbA1c Levels with eGFR and Blood Pressure in Type 2 Diabetes Mellitus Patients in the Department of Internal Medicine Dr. Soetomo General Hospital Surabaya","authors":"Alexander Tikara Sugondo, Deasy Ardiany, Djohar Nuswantoro, Pulus Budiono Notopuro","doi":"10.20473/bhsj.v2i2.14956","DOIUrl":"https://doi.org/10.20473/bhsj.v2i2.14956","url":null,"abstract":"Introduction: Diabetes mellitus is a non-transmitted pandemic disease which had spreaded on a global scale. The prevalence of diabetes mellitus in the world according to the International Diabetes Federation (IDF) is 1.9% and diabetes mellitus is ranked seventh as the cause of death in the world, around 95% in the world is type 2 diabetes mellitus. According to Riset Kesehatan Dasar (Riskesdas) in 2013, the prevalence of diabetes mellitus in Indonesia is 6,9%. Type 2 diabetes mellitus that is not well controlled will increase the risk of chronic complications, both microangiopathies such as nephropathy, and macroangiopathy such as hypertension. The aim of the study was to determine correlation between HbA1c levels with eGFR (Estimated Glomerulus Filtration Rate) and blood pressure (systolic and diastolic).Methods: An analytic observational cross-sectional study, collecting the data from 94 patients with type 2 diabetes mellitus, Dr. Soetomo General Hospital, Surabaya, from January to May 2018. The variables were collected from patient’s medical records. Analysis using Spearman’s Rank Correlation test. To determine normality of the data, we use Kolmogorov-smirnov test.Results: The results showed that there are 134 (57,8%) patients with type 2 diabetes mellitus are female more than male. Patients with greater than or equal to 45 years old were 203 (87,5%) patients, more than under 45 years old. The correlation test showed that there was no significant correlation between HbA1c and systolic blood pressure (r=-0,127; p=0,054). Also there was no significant correlation between HbA1c and diastolic blood pressure (r=-0,111; p=0,093). Analysis on other factor showed a significant correlation between HbA1c and eGFR (r=0.341; p=0.000).Conclusion: There was no significant correlation between HbA1c and systolic blood pressure, also there was no significant correlation between HbA1c and diastolic blood pressure. But, there was a significant correlation between HbA1c and eGFR. This is because the data retrieval does not consider the drug consumption and therapy that has been done by the patient, as well as examination of HbA1c, serum creatinine eGFR, and blood pressure not at the same time.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87370173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-31DOI: 10.20473/BHSJ.V2I2.14963
Riska Afrina, A. Karimah
Introduction: Pain is a complex stressor that has a major influence on several aspects of a person's physical, psychological, work and financial functions, especially in the form of chronic pain. The approach to chronic pain medically can sometimes not solve the problem as a whole, so that in its management psychological approaches such as cognitive and behavioral therapy (CBT) are needed.Methods: We searched PubMed, Science Direct, and Google Scholar for search articles in English terms "chronic pain", "cognitive behavioral therapy", "pain management", and "efficacy". Searching using the keywords above showed 40 articles, but which were taken were 8 articles from the last 5 years.Results: The method of intervention was carried out with a cognitive-behavioral approach in the form of traditional CBT, telephone-based CBT, coping skills training, cognitive-behavioral based physical therapy or CBT-based self-management. The research parameters used to measure the success rate of the interventions were pain intensity, physical function, psychological pressure, disability, fatigue, quality of life, coping strategies, catastrophization, and depression. The duration of the study varied from 5 weeks to 10 weeks, with a variation of 20-60 minutes per therapy session, except in studies using group therapy can take up to 5-7 hours per day. Some studies also conducted evaluation at the third and six months after treatment. The aim of the CBT approach was to independently improve self-efficacy in pain management.Conclusion: Cognitive behavioral approaches combined with other therapeutic modalities can improve the physical function of patients with chronic pain.
{"title":"Cognitive Behavioral Therapy for Chronic Pain","authors":"Riska Afrina, A. Karimah","doi":"10.20473/BHSJ.V2I2.14963","DOIUrl":"https://doi.org/10.20473/BHSJ.V2I2.14963","url":null,"abstract":"Introduction: Pain is a complex stressor that has a major influence on several aspects of a person's physical, psychological, work and financial functions, especially in the form of chronic pain. The approach to chronic pain medically can sometimes not solve the problem as a whole, so that in its management psychological approaches such as cognitive and behavioral therapy (CBT) are needed.Methods: We searched PubMed, Science Direct, and Google Scholar for search articles in English terms \"chronic pain\", \"cognitive behavioral therapy\", \"pain management\", and \"efficacy\". Searching using the keywords above showed 40 articles, but which were taken were 8 articles from the last 5 years.Results: The method of intervention was carried out with a cognitive-behavioral approach in the form of traditional CBT, telephone-based CBT, coping skills training, cognitive-behavioral based physical therapy or CBT-based self-management. The research parameters used to measure the success rate of the interventions were pain intensity, physical function, psychological pressure, disability, fatigue, quality of life, coping strategies, catastrophization, and depression. The duration of the study varied from 5 weeks to 10 weeks, with a variation of 20-60 minutes per therapy session, except in studies using group therapy can take up to 5-7 hours per day. Some studies also conducted evaluation at the third and six months after treatment. The aim of the CBT approach was to independently improve self-efficacy in pain management.Conclusion: Cognitive behavioral approaches combined with other therapeutic modalities can improve the physical function of patients with chronic pain.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85264972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-31DOI: 10.20473/BHSJ.V2I2.15410
P. Saputra, N. Rochmah, Nurul Wiqoyah
Introduction: Preterm and fullterm breast milk has different leukocyte and bioactive concentration, which affect it’s bactericidal activity and storage duration. The preterm breast milk potentially has longer storage duration than fullterm breast milk The research and guideline about the acceptable of storage duration of preterm breast milk at 4o C was limited. The objective of this study was to assess the correlation of storage duration of preterm breast milk preterm baby at 4o C temperature on bacterial growth.Methods: The study design was experimental using pre-post control groups design. We used 9 samples of breast milk which met the inclusion criteria divided into 3 groups. The first, second and third groups was storage in 4o C for 0, 24 and 48 hours respectively before the inoculation to the culture media.Results: After the samples were kept at 4o C temperature for 0, 24 and 48 hours, the mean bacterial colony forming unit for each group were 92 (±SD 112), 79 (±SD 97) and 63 (±SD 73) CFU respectively. Compared to the first group, the second and third group has lower bacterial colony forming unit but no significant differences statistically (P= 0.214 and P=1.39 respectively). Likewise there was no significant bacterial colony forming unit between second and third group (P=0.086).Conclusion: Storage of preterm breast milk in 4o C for 24 and 48 hours show no change in total bacterial colony count (TBCC)..
{"title":"The Comparison of Breast milk from Mother with Preterm Infant at 4o C Temperature in 0, 24 and 48 Hours on Bacterial Growth","authors":"P. Saputra, N. Rochmah, Nurul Wiqoyah","doi":"10.20473/BHSJ.V2I2.15410","DOIUrl":"https://doi.org/10.20473/BHSJ.V2I2.15410","url":null,"abstract":"Introduction: Preterm and fullterm breast milk has different leukocyte and bioactive concentration, which affect it’s bactericidal activity and storage duration. The preterm breast milk potentially has longer storage duration than fullterm breast milk The research and guideline about the acceptable of storage duration of preterm breast milk at 4o C was limited. The objective of this study was to assess the correlation of storage duration of preterm breast milk preterm baby at 4o C temperature on bacterial growth.Methods: The study design was experimental using pre-post control groups design. We used 9 samples of breast milk which met the inclusion criteria divided into 3 groups. The first, second and third groups was storage in 4o C for 0, 24 and 48 hours respectively before the inoculation to the culture media.Results: After the samples were kept at 4o C temperature for 0, 24 and 48 hours, the mean bacterial colony forming unit for each group were 92 (±SD 112), 79 (±SD 97) and 63 (±SD 73) CFU respectively. Compared to the first group, the second and third group has lower bacterial colony forming unit but no significant differences statistically (P= 0.214 and P=1.39 respectively). Likewise there was no significant bacterial colony forming unit between second and third group (P=0.086).Conclusion: Storage of preterm breast milk in 4o C for 24 and 48 hours show no change in total bacterial colony count (TBCC)..","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87997051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Black cumin (Nigella sativa) is widely used to treat various diseases. It is also believed to relief skin conditions accompanied by itching symptom, such as atopic dermatitis (AD) or eczema. However, the anti-eczema mechanism of action is still unclear. The aims of this syudy was to identify anti-eczema mechanism of action of N. sativa for AD using computer aided prediction and pathway analysis based on protein-chemical networks. Methods: We utilized dataset consisting chemical compounds of N. sativa from KNApSAcK. It is a comprehensive species-metabolite relationship database. Using canonical SMILES strings that encode molecular structures of each compound, we predicted the probabilities of activity (Pa) for anti-eczema effect based on PASS algorithms. The compounds with Pa >0.7 were included for pathway analysis based on protein-chemical interaction networks in STITCH database. We selected interactomes built by experimental data, gene co-expression, closest gene position, fusion, co-occurence, computational prediction, and other secondary data. Results: Thirty-five active compounds of N. sativa have been utilized and 19 of them have potential anti-eczema effects. Oleic acid and lauric acid were predicted with Pa-value of 0.947 and 0.920 for anti-eczema effect, respectively. However, only lauric acid was confirmed having a plausible mechanism of action via LY96-TLR4- PIK3R1 pathway for lipopolysaccharide receptor activity (false discovery rate [FDR] = 0.0243) and low-density lipoprotein particle receptor binding (FDR = 0.0118). Conclusion: Lauric acid in N. sativa has potential antieczema effect to prevent relaps in AD patients by controlling opportunistic bacterial infection that aggravates itching symptom in this condition.
{"title":"Anti-eczema Mechanism of Action of Nigella sativa for Atopic Dermatitis: Computer-aided Prediction and Pathway Analysis Based on Protein-chemical Interaction Networks","authors":"Meidyta Sinantryana Widyaswari, Iis Noventi, Herdiantri Supriyana","doi":"10.20473/BHSJ.V2I2.15007","DOIUrl":"https://doi.org/10.20473/BHSJ.V2I2.15007","url":null,"abstract":"Introduction: Black cumin (Nigella sativa) is widely used to treat various diseases. It is also believed to relief skin conditions accompanied by itching symptom, such as atopic dermatitis (AD) or eczema. However, the anti-eczema mechanism of action is still unclear. The aims of this syudy was to identify anti-eczema mechanism of action of N. sativa for AD using computer aided prediction and pathway analysis based on protein-chemical networks. Methods: We utilized dataset consisting chemical compounds of N. sativa from KNApSAcK. It is a comprehensive species-metabolite relationship database. Using canonical SMILES strings that encode molecular structures of each compound, we predicted the probabilities of activity (Pa) for anti-eczema effect based on PASS algorithms. The compounds with Pa >0.7 were included for pathway analysis based on protein-chemical interaction networks in STITCH database. We selected interactomes built by experimental data, gene co-expression, closest gene position, fusion, co-occurence, computational prediction, and other secondary data. Results: Thirty-five active compounds of N. sativa have been utilized and 19 of them have potential anti-eczema effects. Oleic acid and lauric acid were predicted with Pa-value of 0.947 and 0.920 for anti-eczema effect, respectively. However, only lauric acid was confirmed having a plausible mechanism of action via LY96-TLR4- PIK3R1 pathway for lipopolysaccharide receptor activity (false discovery rate [FDR] = 0.0243) and low-density lipoprotein particle receptor binding (FDR = 0.0118). Conclusion: Lauric acid in N. sativa has potential antieczema effect to prevent relaps in AD patients by controlling opportunistic bacterial infection that aggravates itching symptom in this condition.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84569943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-31DOI: 10.20473/bhsj.v2i2.14964
Husin Thamrin, A. Sutjahjo, Agung Pranoto, S. Soelistijo
Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031 Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.
背景:代谢综合征是心血管疾病和慢性肾脏疾病发生的危险因素。根据IDF，当中心性肥胖伴有2种或2种以上代谢异常，包括糖代谢受损、血压升高、高甘油三酯血症和低HDL-C时，诊断为代谢综合征。先前的一些研究报道了代谢综合征与蛋白尿之间的显著关联。在印度尼西亚，2型糖尿病患者代谢综合征与蛋白尿的关系尚未报道。目的:探讨2型糖尿病患者代谢综合征与蛋白尿的关系。方法:这是一项分析性观察性研究，在2型糖尿病患者中进行横断面设计，我们研究了131名受试者。根据IDF共识诊断代谢综合征，使用ACR方法评估蛋白尿，蛋白尿的分类基于Perkeni 2006共识。统计分析采用spearman相关和Mann-whitney检验。采用显著性水平为0.05。结果:131例2型糖尿病代谢综合征患者中，正常蛋白尿比例为65.4%，微量蛋白尿比例为27.1%，大量蛋白尿比例为7.5%。收缩压与蛋白尿有显著相关性，p = 0.000, r = 0.325。空腹血糖伴蛋白尿，p = 0.01, r = 0.223。但舒张压与蛋白尿无显著相关性，p = 0.153, r = 0.125;腰围与蛋白尿无显著相关性，p = 0.311, r = 0.089;低HDL与蛋白尿无显著相关性，p = 0.771, r = -0.025。结论:本研究结果提示代谢综合征、收缩压与白蛋白尿、空腹血糖与白蛋白尿之间存在较强的相关性。而舒张压、腰围、低高密度脂蛋白和高甘油三酯血症没有发现显著关联。
{"title":"Association of Metabolic Syndrome with Albuminuria in Diabetes Mellitus Type 2","authors":"Husin Thamrin, A. Sutjahjo, Agung Pranoto, S. Soelistijo","doi":"10.20473/bhsj.v2i2.14964","DOIUrl":"https://doi.org/10.20473/bhsj.v2i2.14964","url":null,"abstract":"Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031 Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90878152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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