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https://researchopenworld.com/lactobacillary-endocervicitis-a-novel-cause-of-chronic-cervicitis/# https://researchopenworld.com/lactobacillary-endocervicitis-a-novel-cause-of-chronic-cervicitis/#
Pub Date : 2019-12-23 DOI: 10.31038/awhc.2019266
T. Krech, Sandra Kilgus-Hawelski
We are describing a not yet documented cause for mucopurulent endocervicitis which is triggered by the reaction of neutrophil granulocytes against lactobacilli and is referred to as “lactobacillary endocervicitis” in this contribution. Lactobacilli are a normal component of the vaginal flora. Samples from 16 chronic cervicitis were collected by swabbing the portion. Direct microscopy of the samples showed Gram-positive rods among polymorphonuclear cells (more than 10 per high-power field). Many of the polymorphonuclear cells try to phagocytize the rods All samples tested negative by polymerase chain reaction (PCR) for Chlamydia trachomatis , Neisseria gonorrhoea , Ureaplasma urealyticum , Ureaplasma , M.hominis and M.genitalium . Random samples were also tested for Trichomonas vaginalis and/or human papillomavirus by PCR and resulted negative. None of the women showed signs of bacterial vaginosis. Neither clue cells (by microscopy) nor Gardnerella vaginalis (by culture) were detected in these cases. The 16 observed patients with lactobacillary endocervicitis
我们描述了一种尚未记录的粘液化脓性宫颈内膜炎的原因,它是由中性粒细胞对乳酸菌的反应引发的,在这篇文章中被称为“乳酸菌性宫颈内膜炎”。乳酸菌是阴道菌群的正常组成部分。对16例慢性宫颈炎患者进行部分拭子采集。样品的直接显微镜显示革兰氏阳性棒在多形核细胞中(每高倍视场超过10个)。所有样品经聚合酶链反应(PCR)检测,沙眼衣原体、淋病奈瑟菌、解脲支原体、脲原体、人原体和生殖道支原体均呈阴性。随机抽样检测阴道毛滴虫和/或人乳头瘤病毒的PCR结果均为阴性。这些女性都没有表现出细菌性阴道病的迹象。在这些病例中均未检测到线索细胞(镜检)和阴道加德纳菌(培养)。观察16例乳酸菌性宫颈内膜炎患者
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引用次数: 1
https://researchopenworld.com/migraine-a-review-of-basic-clinical-and-translational-approaches-to-new-treatment/# https://researchopenworld.com/migraine-a-review-of-basic-clinical-and-translational-approaches-to-new-treatment/#
Pub Date : 2019-11-25 DOI: 10.31038/awhc.2019263
Jared Wahl, T. Vanderah
Migraine is a debilitating neurological primary headache disorder characterized by recurring unipolar headaches lasting 4–72 hours with accompaniment of nausea and sensory sensitivities. Migraine is the most common headache disorder resulting in seeking of medical care [1, 2], in addition to being one of the most debilitating chronic disease conditions in terms of both morbidity and lost economic productivity. Migraine incidence has been observed since ancient times to disproportionately affect women, and most current epidemiological assessments put current incidence estimates at 12% overall for US populations, with an incidence of 18% in women and 6% in men when stratified by sex. This dimorphism of incidence is crucial when assessing overall health of a community, specifically when concerning women’s health and therefore must be taken into consideration when developing both clinical and basic models of migraine to enact the best possible outcomes of combined translational research efforts. While major recent advances have been made in the field of pharmacologic intervention for migraine with the recent approval of the anti CGRP and anti CGRP receptor antibody medications, prohibitive cost and limited access have made older treatments, such as the triptans and NSAIDs, still the most commonly utilized medications to combat migraine attacks. Current preclinical research models are heavily interested in modulation of the neuropeptide CGRP, and the phenomenon of cortical spreading depression (CSD), believed to be the underlying trigger of migraine with aura, via pharmacological intervention. Modulations of these phenomena has found to be correlated with menstrual events in women, tying back to the overarching theme of higher morbidity in women. With the advent of pharmacogenomics and personalized medicine, a new epoch of potential customizable treatments looms on the horizon, endearing those afflicted with this severely debilitating condition a new glimmer of hope as research progresses into its next phase. Acronyms: AMPP: American Migraine Prevalence and Prevention study. NIH: National Institute of Health. ICHD-3: International Classification of Headache Disorders, 3rd edition. NHIS: National Health Interview Survey. NSAID: Non-Steroidal Anti-Inflammatory Drug. CGRP: Calcitonin Gene Related Peptide. 5HT1: 5-Hydroxytryptamine (Serotonin) Receptor, Subfamily 1. FDA: Food and Drug Administration. CNS: Central Nervous System. MOH: Medication Overuse Headache. PGE2: Prostaglandin E2. CSD: Cortical Spreading depression. fMRI: Functional Magnetic Resonance Imaging. GWAS: Genome Wide Association Study. SNP: Single Nucleotide Polymorphism.
偏头痛是一种使人衰弱的神经性原发性头痛疾病,其特点是反复发作的单极性头痛,持续4-72小时,伴有恶心和感觉敏感。偏头痛是最常见的导致就医的头痛疾病[1,2],此外,就发病率和经济生产力损失而言,偏头痛也是最使人衰弱的慢性疾病之一。自古以来,人们就观察到偏头痛对女性的影响不成比例,目前大多数流行病学评估认为,美国人口目前的发病率估计为12%,按性别分层时,女性发病率为18%,男性发病率为6%。在评估一个社区的整体健康时,这种发病率的二态性是至关重要的,特别是在涉及妇女健康时,因此在开发偏头痛的临床和基础模型时必须考虑到这一点,以制定联合转化研究努力的最佳结果。随着抗CGRP和抗CGRP受体抗体药物的批准,最近在偏头痛的药物干预领域取得了重大进展,但高昂的成本和有限的获取使得旧的治疗方法,如曲坦类药物和非甾体抗炎药,仍然是最常用的治疗偏头痛的药物。目前的临床前研究模型非常关注神经肽CGRP的调节,以及通过药物干预被认为是先兆偏头痛的潜在触发因素的皮质扩张性抑制(CSD)现象。这些现象的调节已被发现与女性的月经事件相关,并与女性发病率较高的首要主题联系起来。随着药物基因组学和个性化医学的出现,一个潜在的定制治疗的新时代隐约出现在地平线上,随着研究进入下一阶段,那些受这种严重衰弱疾病折磨的人看到了新的希望。缩写词:AMPP:美国偏头痛患病率和预防研究。美国国立卫生研究院。ICHD-3:国际头痛疾病分类,第三版。全国健康访谈调查。非甾体抗炎药。CGRP:降钙素基因相关肽5HT1: 5-羟色胺(5-羟色胺)受体,亚家族1FDA:食品和药物管理局。CNS:中枢神经系统。卫生部:药物过度使用头痛。PGE2:前列腺素E2。CSD:皮质扩张性凹陷。功能磁共振成像。全基因组关联研究。SNP:单核苷酸多态性。
{"title":"https://researchopenworld.com/migraine-a-review-of-basic-clinical-and-translational-approaches-to-new-treatment/#","authors":"Jared Wahl, T. Vanderah","doi":"10.31038/awhc.2019263","DOIUrl":"https://doi.org/10.31038/awhc.2019263","url":null,"abstract":"Migraine is a debilitating neurological primary headache disorder characterized by recurring unipolar headaches lasting 4–72 hours with accompaniment of nausea and sensory sensitivities. Migraine is the most common headache disorder resulting in seeking of medical care [1, 2], in addition to being one of the most debilitating chronic disease conditions in terms of both morbidity and lost economic productivity. Migraine incidence has been observed since ancient times to disproportionately affect women, and most current epidemiological assessments put current incidence estimates at 12% overall for US populations, with an incidence of 18% in women and 6% in men when stratified by sex. This dimorphism of incidence is crucial when assessing overall health of a community, specifically when concerning women’s health and therefore must be taken into consideration when developing both clinical and basic models of migraine to enact the best possible outcomes of combined translational research efforts. While major recent advances have been made in the field of pharmacologic intervention for migraine with the recent approval of the anti CGRP and anti CGRP receptor antibody medications, prohibitive cost and limited access have made older treatments, such as the triptans and NSAIDs, still the most commonly utilized medications to combat migraine attacks. Current preclinical research models are heavily interested in modulation of the neuropeptide CGRP, and the phenomenon of cortical spreading depression (CSD), believed to be the underlying trigger of migraine with aura, via pharmacological intervention. Modulations of these phenomena has found to be correlated with menstrual events in women, tying back to the overarching theme of higher morbidity in women. With the advent of pharmacogenomics and personalized medicine, a new epoch of potential customizable treatments looms on the horizon, endearing those afflicted with this severely debilitating condition a new glimmer of hope as research progresses into its next phase. Acronyms: AMPP: American Migraine Prevalence and Prevention study. NIH: National Institute of Health. ICHD-3: International Classification of Headache Disorders, 3rd edition. NHIS: National Health Interview Survey. NSAID: Non-Steroidal Anti-Inflammatory Drug. CGRP: Calcitonin Gene Related Peptide. 5HT1: 5-Hydroxytryptamine (Serotonin) Receptor, Subfamily 1. FDA: Food and Drug Administration. CNS: Central Nervous System. MOH: Medication Overuse Headache. PGE2: Prostaglandin E2. CSD: Cortical Spreading depression. fMRI: Functional Magnetic Resonance Imaging. GWAS: Genome Wide Association Study. SNP: Single Nucleotide Polymorphism.","PeriodicalId":93266,"journal":{"name":"Archives of women health and care","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82842284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
https://researchopenworld.com/gps-should-actively-ask-about-symptoms-of-urinary-or-faecal-incontinence-in-ageing-female-patients/# https://researchopenworld.com/gps-should-actively-ask-about-symptoms-of-urinary-or-faecal-incontinence-in-ageing-female-patients/#
Pub Date : 2019-11-22 DOI: 10.31038/awhc.2019264
T. Seppälä, Ala-Nissilä Seija, Joronen Kirsi, L. Maren, Kauppila Marjo, Hautaniemi Soili, Rantanen Virpi
Objectives: To investigate how common incontinence problem is and how it could be detected in an unselected population. Methods: Cross-sectional study in primary care population. A population survey of women born in 1948 or 1950 and living in a municipality with 19,535 inhabitants in south-western Finland in 2017. Main outcome measures were i ncidence of urinary or faecal incontinence. Results: After analyzing the questionnaires and research findings, we found that urinary incontinence is a common phenomenon, reported by 50.3% of participants. According to the Urinary Incontinence Severity Score (UISS), 12.7% of them believed that the degree of disability was remarkable, and according to the Visual Analogue Scale (VAS), 18.3% considered the degree of disability to be difficult. In this study obesity was the most common feature affecting urinary incontinence. Conclusion: Urinary incontinence is a common problem and will increase as the population ages. It can deteriorate a person’s quality of life, increase her need of care and involve considerable costs. Preventing the problem and treating it as early as possible in primary health-care is both reasonable and saves time and money. Urinary incontinence is a common problem in the ageing female population. Many women are ashamed of their incontinence and do not even mention it during the GP’s consultation. Preventing the problem and treating it as early as possible in primary healthcare is important.
目的:调查尿失禁问题的常见程度,以及如何在非选择性人群中检测出尿失禁。方法:对初级保健人群进行横断面研究。2017年,一项针对出生于1948年或1950年、居住在芬兰西南部一个拥有19535名居民的自治市的女性的人口调查。主要观察指标为尿失禁或大便失禁的发生率。结果:通过对问卷调查和研究结果的分析,我们发现尿失禁是一种常见的现象,50.3%的参与者报告了尿失禁。根据尿失禁严重程度评分(UISS), 12.7%的人认为残疾程度显著,根据视觉模拟量表(VAS), 18.3%的人认为残疾程度困难。在这项研究中,肥胖是影响尿失禁的最常见特征。结论:尿失禁是一种常见病,并随着人口老龄化而增加。它会降低一个人的生活质量,增加她对护理的需求,并涉及相当大的费用。在初级保健中预防和尽早治疗这一问题既合理又节省时间和金钱。尿失禁是老年女性的常见问题。许多女性对自己的尿失禁感到羞耻,甚至在全科医生咨询时都不提。在初级卫生保健中预防和尽早治疗这一问题非常重要。
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引用次数: 0
https://researchopenworld.com/social-media-controversy-affecting-the-introduction-of-hpv-vaccination-for-young-girls-in-cameroon/# https://researchopenworld.com/social-media-controversy-affecting-the-introduction-of-hpv-vaccination-for-young-girls-in-cameroon/#
Pub Date : 2019-10-21 DOI: 10.31038/awhc.2019255
A. Amani, S. K. Nolna, Mireille Ndje Ndje, C. B. Ndongo, Marceline, Djuidje Ngounoue, B. A. Tiedeu, R. Leke
Cervical cancer is the second most frequent type of cancer in Cameroon [1]. More than 7.1 million Cameroonian women aged 15 and above are at risk of this disease [2]. In the past ten years, various pilot projects have demonstrated the efficacy and acceptability of Gardasil TM, the vaccine against Human Papillomavirus (HPV) [3,4]. Based on these successful demonstration phases, with the support of the Global Alliance for Vaccines and Immunization (GAVI), the HPV vaccine is finally being implemented countrywide by the Ministry of Public Health. The main objective of the vaccine roll-out will be to immunize at least 80% of 9-year-old girls, and thus reduce the morbidity and mortality due to cervical cancer and other HPV-related infections in Cameroon.
宫颈癌是喀麦隆第二常见的癌症类型[1]。超过710万15岁及以上的喀麦隆妇女有患此病的风险[2]。在过去的十年中,各种试点项目已经证明了Gardasil TM的有效性和可接受性,这是一种针对人乳头瘤病毒(HPV)的疫苗[3,4]。基于这些成功的示范阶段,在全球疫苗和免疫联盟(免疫联盟)的支持下,人乳头瘤病毒疫苗终于由公共卫生部在全国范围内实施。推广疫苗的主要目标将是为至少80%的9岁女孩进行免疫接种,从而降低喀麦隆宫颈癌和其他hpv相关感染的发病率和死亡率。
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引用次数: 0
https://researchopenworld.com/midlife-women-and-the-opioid-crisis-commentary-on-the-role-of-integrative-health/# https://researchopenworld.com/midlife-women-and-the-opioid-crisis-commentary-on-the-role-of-integrative-health/#
Pub Date : 2019-10-19 DOI: 10.31038/awhc.2019261
L. Taylor-Swanson, S. Simonsen, M. Koithan
Midlife women are experiencing increased rates of opioid use disorder (OUD) [1] and fatal overdose in the United States (US) [2]. Rates of opioid-related mortality have increased more rapidly among women than men [3], and when stratified by age, the increase in opioid-related mortality is particularly notable among middle-aged women [4]. Unique risk factors for opioid misuse and opioid use disorder (OUD) in women have been identified, including higher pain levels and increased opioid withdrawal symptoms [5] among women with OUD and higher rates of psychological comorbidities [6,7]. In addition, midlife women with co-occurring chronic pain and menopausal symptoms experience increased rates of risky opioid use including long-term opioid use, high-dose opioid use, and coprescription of CNS-depressants and opioids [8]. Thus, addressing pain, menopausal symptoms, and psychological comorbidities may help reduce rates of OUD and ultimately prevent fatal overdose among midlife women.
在美国(US),中年女性的阿片类药物使用障碍(OUD)[1]和致命的过量服用[2]的比例正在上升。阿片类药物相关死亡率在女性中的增长速度比男性快[3],如果按年龄分层,阿片类药物相关死亡率的增长在中年女性中尤为显著[4]。已经确定了女性阿片类药物滥用和阿片类药物使用障碍(OUD)的独特危险因素,包括患有OUD的女性疼痛程度更高,阿片类药物戒断症状增加[5],心理合并症发生率更高[6,7]。此外,同时出现慢性疼痛和更年期症状的中年妇女使用阿片类药物的风险增加,包括长期使用阿片类药物、使用大剂量阿片类药物以及同时使用中枢神经系统抑制剂和阿片类药物[8]。因此,解决疼痛、更年期症状和心理合并症可能有助于降低OUD的发生率,并最终防止中年妇女服药过量致死。
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引用次数: 0
https://researchopenworld.com/preparing-nursing-students-to-meet-public-expectations-while-preserving-professional-values-mind-genomics-cartography-of-the-publics-voice/# https://researchopenworld.com/preparing-nursing-students-to-meet-public-expectations-while-preserving-professional-values-mind-genomics-cartography-of-the-publics-voice/#
Pub Date : 2019-10-17 DOI: 10.31038/awhc.2019262
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引用次数: 0
https://researchopenworld.com/prenatal-weight-management-what-can-care-providers-do-to-prevent-maternal-excessive-weight-gain/# https://researchopenworld.com/prenatal-weight-management-what-can-care-providers-do-to-prevent-maternal-excessive-weight-gain/#
Pub Date : 2019-10-14 DOI: 10.31038/awhc.2019253
C. Shieh
Maternal prenatal weight data can be used to estimate infant birth weight, connect weight concerns of the women before and after pregnancy, and prevent offspring obesity. Prenatal weight data can be interpreted in relation to many contexts, such as BMI, weight loss or gain, body fat, and patient perspectives. The primary goals for weight management during pregnancy include helping pregnant women achieve an optimal weight but to avoid excessive gestational weight gain. To prevent excessive gestational weight gain among pregnant women, healthcare providers can focus on utilizing integrated and inter professional collaborative team care approach, the 5A’s method for lifestyle counseling, and self-monitoring strategy to empower pregnant women for behavioral change. Prenatal weight management is important for a healthy pregnancy with short- and long-term health implications for the mother and the baby.
孕妇产前体重数据可用于估计婴儿出生体重,连接妇女孕前和孕后的体重问题,预防后代肥胖。产前体重数据可以在许多情况下解释,如体重指数、体重减轻或增加、体脂和患者的观点。孕期体重管理的主要目标包括帮助孕妇达到最佳体重,同时避免孕期体重过度增加。为防止孕妇妊娠期体重过度增加,医疗服务提供者可以重点利用综合和跨专业协作团队护理方法、5A生活方式咨询方法和自我监测策略,增强孕妇行为改变的能力。产前体重管理对健康怀孕很重要,对母亲和婴儿的短期和长期健康都有影响。
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引用次数: 0
https://researchopenworld.com/perinatal-and-child-mortality-under-nutrition-and-cerebral-palsy-a-cross-sectional-survey-in-rural-bangladesh/# https://researchopenworld.com/perinatal-and-child-mortality-under-nutrition-and-cerebral-palsy-a-cross-sectional-survey-in-rural-bangladesh/#
Pub Date : 2019-10-13 DOI: 10.31038/awhc.2019254
James Whitehall, Phillip Barnden, M. Rana, L. Wieland, D. Gillespie, Oliver Charlton, Me Cooper, Vedant Dave, Tom Hall, Sean Hanly, Sophie Higham, Gajanth, Sivapalan, Samantha Tripp, Gemma Walmsley, Samuel Watson, J. Whitehall
1Data analysis, writer, Paediatrics, Western Sydney University, Australia 2Programme organiser, Programme Officer, Symbiosis International, Bangladesh 3Programme organiser, Associate Programme Director, Mennonite Central Committee, Bangladesh 4Supervisor, Paediatrics, Western Sydney University, Australia 5Investigator Paediatrics, Western Sydney University, Australia 6Programme Director, Analysis and Writer Paediatrics, Western Sydney University, Australia
1 .数据分析,儿科作家,西悉尼大学,澳大利亚2 .项目组织者,项目官员,共生国际,孟加拉国3 .项目组织者,项目副主任,门诺派中央委员会,孟加拉国4 .主管,儿科,西悉尼大学,澳大利亚5 .调查员儿科,西悉尼大学,澳大利亚6 .项目主任,分析和儿科作家,西悉尼大学,澳大利亚
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引用次数: 0
https://researchopenworld.com/perinatal-mental-health-care-across-the-globe/# https://researchopenworld.com/perinatal-mental-health-care-across-the-globe/#
Pub Date : 2019-10-03 DOI: 10.31038/awhc.2019251
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引用次数: 0
https://researchopenworld.com/microarray-testing-for-symmetrical-intrauterine-growth-retardation/# https://researchopenworld.com/microarray-testing-for-symmetrical-intrauterine-growth-retardation/#
Pub Date : 2019-08-26 DOI: 10.31038/awhc.2019243
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引用次数: 0
期刊
Archives of women health and care
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