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Intra-Atrial Tunneled Dialysis Catheter as Vascular Access: Ultimate Choice in a Hemodialysis Patient 心房内隧道透析导管作为血管通路:血液透析患者的最终选择
Pub Date : 2021-10-18 DOI: 10.31579/2639-4162/053
M. Sobhi, I. Mami, Soumaya Mekki, Jalel Ziedi, I. Ben Mrad, M. Ben Mrad
Recurrence of complications related to usual vascular access leads to exhausted vasculature. Several options were described in similar cases like tans-lumbar catheter and intra-atrial tunneled dialysis catheter. We report the case of a 22-year-old- male, with kidney failure, anuria and exhausted vasculature. Emergent kidney transplantation was not suitable to his case. We decided to combine peritoneal dialysis with once-a-week hemodialysis using a tans-lumbar tunneled catheter at first time, then an intra-atrial tunneled dialysis catheter as vascular access of last resort. Development of renal replacement therapy expose nephrologist to new challenges. Working on alternative therapy is inspiring, but rationalizing exploitation of current options meanwhile is imperative.
与常规血管通路相关的并发症复发会导致血管系统衰竭。在类似的病例中描述了几种选择,如tans腰椎导管和心房内隧道透析导管。我们报告一例22岁男性,肾功能衰竭,无尿,血管衰竭。紧急肾移植不适合他的情况。我们决定将腹膜透析与每周一次的血液透析相结合,首先使用tans腰椎隧道导管,然后使用心房内隧道透析导管作为最后的血管通路。肾脏替代疗法的发展使肾脏病学家面临新的挑战。研究替代疗法是鼓舞人心的,但同时合理利用当前的选择也是当务之急。
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引用次数: 0
Three-Year Experience of a Multidisciplinary Central Nervous System Clinic Model for Radiation Oncology and Neurosurgery (RADIANS) in a Community Hospital Setting. 社区医院放射肿瘤学和神经外科(RADIANS)多学科中枢神经系统临床模型的三年经验
Pub Date : 2021-10-18 DOI: 10.31579/2639-4162/042
Wencesley A. Paez, Rohi Gheewala, S. McClelland, J. Jaboin, Charles R. Thomas, B. Lucke-Wold, J. Ciporen, T. Mitin
BackgroundAs academic centers partner and establish healthcare systems with community hospitals, delivery of subspecialty, multidisciplinary care in community hospital settings remains a challenge. Improving outcomes for central nervous system (CNS) disease is related to integrated care between neurosurgery (NS) and radiation oncology (RadOnc) specialties. Our multidisciplinary community hospital-based clinic, RADIANS, previously reported high patient approval of simultaneous evaluation with NS and RadOnc physicians. Three-year experience is now reported.MethodsProspectively collected clinical and demographic patient data over three years was done, and surveys administered. Descriptive statistics reported as mean and percentages for patient characteristics, diagnosis, treatment and outcomes.ResultsBetween August 2016 and August 2019, 101 patients were evaluated. Mean age and distanced traveled was 61.2 years, and 54.9 miles, respectively. Patient Satisfaction Score was 4.79 (0-5 Scale, 5-very satisfied). Most common referral source was medical oncologists. Seventy-two patients had malignant CNS disease (brain mets 28; spine mets 27; both 6; primary brain 9; primary spine 2), 29 had benign CNS disease. Post-evaluation treatment: radiation therapy (RT) only (n=29), neurosurgery (NS) only (n=16), both RT and NS (n=22), and no RT/NS intervention (n=34). Fractionated stereotactic radiosurgery was most common RT delivered; craniotomy with tumor resection was most common NS performed. Treatment outcomes: local control=61/67 (91%); radiation necrosis or radiation-induced myelitis=2/51 (3.9%).ConclusionsThe RADIANS multidisciplinary community hospital-based CNS clinic model is first of its kind to be reported, continuing strong patient approval at extended follow-up. Data indicates the model serves as a regional referral center, delivering evidence-based treatment modalities for complex CNS disease in community hospital settings, yielding high rates of local control and low rates of grade 3 or 4 radiation-induced toxicity.
随着学术中心与社区医院合作并建立医疗保健系统,在社区医院环境中提供亚专科、多学科护理仍然是一个挑战。改善中枢神经系统(CNS)疾病的预后与神经外科(NS)和放射肿瘤学(RadOnc)专业之间的综合护理有关。我们以多学科社区医院为基础的诊所RADIANS先前报告了患者对NS和RadOnc医生同时评估的高度认可。现在报告三年的经验。方法前瞻性收集3年以上患者的临床和人口学资料,并进行问卷调查。描述性统计报告为患者特征、诊断、治疗和结果的平均值和百分比。结果2016年8月至2019年8月,对101例患者进行了评估。平均年龄和旅行距离分别为61.2岁和54.9英里。患者满意度评分为4.79(0-5分制,5-非常满意)。最常见的转诊来源是内科肿瘤学家。恶性中枢神经系统疾病72例(脑转移28例;脊柱转移27;6;初级脑;原发性脊柱2例,良性中枢神经系统疾病29例。评价后治疗:仅放射治疗(RT) (n=29),仅神经外科(NS) (n=16), RT和NS联合治疗(n=22),无RT/NS干预(n=34)。分割立体定向放射手术是最常见的放射治疗;开颅加肿瘤切除是最常见的NS手术。治疗结果:局部对照=61/67 (91%);放射性坏死或放射性脊髓炎=2/51(3.9%)。结论RADIANS多学科社区医院为基础的中枢神经系统临床模型是首次报道,在长期随访中继续获得患者的强烈认可。数据表明,该模型可作为区域转诊中心,在社区医院环境中为复杂的中枢神经系统疾病提供循证治疗模式,产生高的局部控制率和低的3级或4级辐射引起的毒性。
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引用次数: 2
Three-Year Experience of a Multidisciplinary Central Nervous System Clinic Model for Radiation Oncology and Neurosurgery (RADIANS) in a Community Hospital Setting. 社区医院放射肿瘤学和神经外科多学科中枢神经系统诊疗模式(RADIANS)的三年经验。
Pub Date : 2021-01-01 Epub Date: 2021-04-16
Wencesley Paez, Rohi Gheewala, Shearwood McClelland, Jerry J Jaboin, Charles R Thomas, Brandon Lucke-Wold, Jeremy N Ciporen, Timur Mitin

Background: As academic centers partner and establish healthcare systems with community hospitals, delivery of subspecialty, multidisciplinary care in community hospital settings remains a challenge. Improving outcomes for central nervous system (CNS) disease is related to integrated care between neurosurgery (NS) and radiation oncology (RadOnc) specialties. Our multidisciplinary community hospital-based clinic, RADIANS, previously reported high patient approval of simultaneous evaluation with NS and RadOnc physicians. Three-year experience is now reported.

Methods: Prospectively collected clinical and demographic patient data over three years was done, and surveys administered. Descriptive statistics reported as mean and percentages for patient characteristics, diagnosis, treatment and outcomes.

Results: Between August 2016 and August 2019, 101 patients were evaluated. Mean age and distanced traveled was 61.2 years, and 54.9 miles, respectively. Patient Satisfaction Score was 4.79 (0-5 Scale, 5-very satisfied). Most common referral source was medical oncologists. Seventy-two patients had malignant CNS disease (brain mets 28; spine mets 27; both 6; primary brain 9; primary spine 2), 29 had benign CNS disease. Post-evaluation treatment: radiation therapy (RT) only (n=29), neurosurgery (NS) only (n=16), both RT and NS (n=22), and no RT/NS intervention (n=34). Fractionated stereotactic radiosurgery was most common RT delivered; craniotomy with tumor resection was most common NS performed. Treatment outcomes: local control=61/67 (91%); radiation necrosis or radiation-induced myelitis=2/51 (3.9%).

Conclusions: The RADIANS multidisciplinary community hospital-based CNS clinic model is first of its kind to be reported, continuing strong patient approval at extended follow-up. Data indicates the model serves as a regional referral center, delivering evidence-based treatment modalities for complex CNS disease in community hospital settings, yielding high rates of local control and low rates of grade 3 or 4 radiation-induced toxicity.

背景:随着学术中心与社区医院合作并建立医疗保健系统,在社区医院环境中提供亚专科、多学科护理仍然是一项挑战。改善中枢神经系统(CNS)疾病的治疗效果与神经外科(NS)和放射肿瘤学(RadOnc)专科之间的综合治疗有关。我们以社区医院为基础的多学科诊所 RADIANS 以前曾报告过患者对神经外科和放射肿瘤科医生同时进行评估的高度认可。现报告三年来的经验:方法:前瞻性地收集了三年来患者的临床和人口统计数据,并进行了问卷调查。结果:2016 年 8 月至 2019 年 8 月期间,共接受了 1.5 万名患者的评估:2016年8月至2019年8月期间,共对101名患者进行了评估。平均年龄和旅行距离分别为 61.2 岁和 54.9 英里。患者满意度评分为 4.79(0-5 分制,5 分-非常满意)。最常见的转诊来源是肿瘤内科医生。72名患者患有恶性中枢神经系统疾病(脑部转移28例;脊柱转移27例;两者均为6例;原发性脑部9例;原发性脊柱2例),29名患者患有良性中枢神经系统疾病。评估后的治疗:仅放疗(RT)(29人)、仅神经外科(NS)(16人)、RT和NS(22人)、无RT/NS干预(34人)。最常见的 RT 是分次立体定向放射手术;最常见的 NS 是开颅手术加肿瘤切除术。治疗结果:局部控制=61/67(91%);辐射坏死或辐射诱发脊髓炎=2/51(3.9%):RADIANS多学科社区医院中枢神经系统诊疗模式是首个报道的此类模式,在长期随访中继续得到患者的高度认可。数据显示,该模式可作为区域转诊中心,在社区医院环境中为复杂的中枢神经系统疾病提供循证治疗模式,局部控制率高,3 级或 4 级放射诱导毒性发生率低。
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引用次数: 0
Schistosomiasis Associated Glomerulopathy (Glomerulonephristis / Nephrotic Syndrome): A review and Update of the Literature 血吸虫病相关肾小球疾病(肾小球肾炎/肾病综合征):文献综述和更新
Pub Date : 2020-12-14 DOI: 10.31579/2639-4162/037
A. Venyo
Schistosomiasis may affect a number of organs within the human body. Schistosomiasis may also be associated with glomerular disease of the kidney in the form of glomerulonephritis and nephrotic syndrome. The association between Schistosomiasis and glomerulopathy may not be well known by a number of practitioners and its pathophysiology may not be very well understood and this could be due to the underdiagnosis of the disease due to the possibility of lack of facilities within the Schistosomiasis endemic areas of the world especially within tropical Africa. Nevertheless, there are a number of patterns of renal involvement in Schistosomiasis which include (a) upper urinary tract sequelae of lower urinary tract Schistosomiasis pathology, (b) immune-related glomerulonephritis, (c) as well as oxidant-stress-mediated renal tubular glomerulonephritis. The renal involvement by Schistosomiasis does tend to be ensued by the development of Schistosomiasis-associated Glomerulopathy (Glomerulonephritis / Nephrotic Syndrome) of varying severity. Individuals affected by Schistosomiasis-associated kidney disease may develop (a) asymptomatic disease which tends to related to self-limited and asymptomatic glomerular disease (b) symptomatic disease which most commonly would tend to present with nephrotic syndrome most often in patients who develop hepato-splenic schistosomiasis with liver fibrosis associated with Schistosoma mansoni infection. Symptomatic patients tend to develop severe hypo-proteinemia, half of the patients tend to have elevated blood pressure. In the absence of nephrotic syndrome, patients who have Schistosomiasis-associated glomerulopathy may manifest with: (a) isolated non-nephrotic syndrome proteinuria (b) acute glomerulonephritis associated with haematuria and heavy proteinuria, (c) Nephrotic syndrome together with systemic manifestations of co-infection with salmonella (class II) or hepatitis C virus (Class I), (d) End stage renal disease (ESRD). Some of the patients who have Schistosomiasis of the kidney may present with Haematuria, Hypertension, Hepato-splenic Schistosomiasis. The diagnosis should be suspected with regard to the following scenarios: (a) clinical suspicion in a patient with kidney disease who is known or has been known to have Schistosoma mansoni; (b) exposure to an endemic area, (c) clinical evidence / demonstration of chronic hepatosplenic schistosomiasis, (d) if the patient has not been diagnosed as having been afflicted with schistosomiasis, then schistosomal infection should be documented, (e) majority of patients with schistosomiasis and kidney disease should have kidney biopsy. (f) The patients should be evaluated for co-infection with salmonella, hepatitis C virus, and hepatitis B virus in order to ensure adequate treatment of the disease. Schistosomiasis is the second most devastating tropical parasitic disease globally which tends to be responsible for many urological complications. Nevertheless, glomerular injury
血吸虫病可能影响人体内的许多器官。血吸虫病也可能与肾小球疾病有关,表现为肾小球肾炎和肾病综合征。血吸虫病和肾小球病之间的联系可能不为许多从业者所熟知,其病理生理学也可能不被很好地理解,这可能是由于在世界血吸虫病流行地区,特别是在热带非洲,可能缺乏设施而导致对该病的诊断不足。然而,血吸虫病的肾脏受累有多种模式,包括(a)下尿路血吸虫病病理的上尿路后遗症,(b)免疫相关的肾小球肾炎,(c)以及氧化应激介导的肾小管肾小球肾炎。血吸虫病对肾脏的损害往往伴随着不同程度的血吸虫病相关肾小球病(肾小球肾炎/肾病综合征)的发展。受血吸虫病相关肾脏疾病影响的个体可能会出现(a)无症状疾病,这往往与自限性和无症状肾小球疾病有关;(b)有症状疾病,最常见的是肾病综合征,最常见于肝脾血吸虫病患者,并伴有与曼氏血吸虫感染相关的肝纤维化。有症状的患者往往发展为严重的低蛋白血症,一半的患者往往血压升高。在没有肾病综合征的情况下,血吸虫病相关肾小球病变患者可能表现为:(a)孤立性非肾病综合征蛋白尿(b)伴有血尿和重度蛋白尿的急性肾小球肾炎,(c)肾病综合征并伴有沙门氏菌(II类)或丙型肝炎病毒(I类)感染的全身性表现,(d)终末期肾病(ESRD)。有些肾脏血吸虫病患者可能会出现血尿、高血压、肝脾血吸虫病。应根据以下情况怀疑诊断:(a)临床怀疑患有肾脏疾病的患者,已知或已知患有曼氏血吸虫;(b)暴露于流行地区,(c)慢性肝脾血吸虫病的临床证据/证明,(d)如果患者未被诊断为患有血吸虫病,则应记录血吸虫感染,(e)大多数血吸虫病和肾脏疾病患者应进行肾脏活检。(f)应评估患者是否同时感染沙门氏菌、丙型肝炎病毒和乙型肝炎病毒,以确保对该疾病进行适当治疗。血吸虫病是全球第二大破坏性热带寄生虫病,往往会导致许多泌尿系统并发症。然而,肾小球损伤是一种罕见的并发症,主要或最常被描述为曼森血吸虫。当对血吸虫病相关肾病患者进行管理和长期肾终点随访时,三分之一独立于肾活检组织病理学检查特征的患者倾向于进行透析。膜增生性肾小球肾炎(MPGN)是一种罕见的与血血吸虫感染相关的并发症,往往与潜在的不良预后有关。MPGN可迅速导致终末期肾病(ESRD)。抗蠕虫和免疫抑制药物在疾病晚期往往无效,因此需要将工作重点放在高危人群中血吸虫感染的预防、早期发现和治疗上。为了降低血吸虫相关肾病的发病率,公共卫生政策应侧重于通过控制蜗牛、改善卫生条件和健康教育以及实施和维持以化疗为基础的控制策略来预防该病。考虑到每年都有许多人被发现患有血吸虫病,这些人往往居住在其国家的农村地区,在那里进行肾功能检查和肾脏活检的设施往往不容易获得,因此,在全球范围内,与血吸虫病相关的肾病可能高度未得到诊断。
{"title":"Schistosomiasis Associated Glomerulopathy (Glomerulonephristis / Nephrotic Syndrome): A review and Update of the Literature","authors":"A. Venyo","doi":"10.31579/2639-4162/037","DOIUrl":"https://doi.org/10.31579/2639-4162/037","url":null,"abstract":"Schistosomiasis may affect a number of organs within the human body. Schistosomiasis may also be associated with glomerular disease of the kidney in the form of glomerulonephritis and nephrotic syndrome. The association between Schistosomiasis and glomerulopathy may not be well known by a number of practitioners and its pathophysiology may not be very well understood and this could be due to the underdiagnosis of the disease due to the possibility of lack of facilities within the Schistosomiasis endemic areas of the world especially within tropical Africa. Nevertheless, there are a number of patterns of renal involvement in Schistosomiasis which include (a) upper urinary tract sequelae of lower urinary tract Schistosomiasis pathology, (b) immune-related glomerulonephritis, (c) as well as oxidant-stress-mediated renal tubular glomerulonephritis. The renal involvement by Schistosomiasis does tend to be ensued by the development of Schistosomiasis-associated Glomerulopathy (Glomerulonephritis / Nephrotic Syndrome) of varying severity. Individuals affected by Schistosomiasis-associated kidney disease may develop (a) asymptomatic disease which tends to related to self-limited and asymptomatic glomerular disease (b) symptomatic disease which most commonly would tend to present with nephrotic syndrome most often in patients who develop hepato-splenic schistosomiasis with liver fibrosis associated with Schistosoma mansoni infection. Symptomatic patients tend to develop severe hypo-proteinemia, half of the patients tend to have elevated blood pressure. In the absence of nephrotic syndrome, patients who have Schistosomiasis-associated glomerulopathy may manifest with: (a) isolated non-nephrotic syndrome proteinuria (b) acute glomerulonephritis associated with haematuria and heavy proteinuria, (c) Nephrotic syndrome together with systemic manifestations of co-infection with salmonella (class II) or hepatitis C virus (Class I), (d) End stage renal disease (ESRD). Some of the patients who have Schistosomiasis of the kidney may present with Haematuria, Hypertension, Hepato-splenic Schistosomiasis. The diagnosis should be suspected with regard to the following scenarios: (a) clinical suspicion in a patient with kidney disease who is known or has been known to have Schistosoma mansoni; (b) exposure to an endemic area, (c) clinical evidence / demonstration of chronic hepatosplenic schistosomiasis, (d) if the patient has not been diagnosed as having been afflicted with schistosomiasis, then schistosomal infection should be documented, (e) majority of patients with schistosomiasis and kidney disease should have kidney biopsy. (f) The patients should be evaluated for co-infection with salmonella, hepatitis C virus, and hepatitis B virus in order to ensure adequate treatment of the disease. Schistosomiasis is the second most devastating tropical parasitic disease globally which tends to be responsible for many urological complications. Nevertheless, glomerular injury","PeriodicalId":93288,"journal":{"name":"General medicine and clinical practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43775531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red Blood Cell Distribution Width/Hemoglobin Ratio Correlate with Severity of Clinical Status in Residents of Long-term Geriatric and Palliative Care 长期接受老年和姑息治疗的居民红细胞分布宽度/血红蛋白比值与临床状况严重程度的相关性
Pub Date : 2020-12-14 DOI: 10.31579/2639-4162/038
Jochanan E. Naschitz, Igor Yalonetzki, G. Leibovitz, Nathalia Zaigraykin
Background: The red blood cell distribution width (RDW) is a simple measure of red blood cell size heterogeneity. A high degree of anisocytosis, expressed by RDW >15%, is observed in certain anemias, but also in other disorders, where RDW >15% is associated with worse prognosis. We questioned whether the RDW/hemoglobin ratio (RDW/Hb) might closer relate to disease severity than RDW. Design: Cross sectional study Patients: 76 residents of two Department of Comprehensive Nursing Care. Method: Physicians classified the patients according to their clinical status in three groups: "stable", “severe-unstable”, and "intermediate". An outside observer extracted from the patients' files the results of RDW (elevated if >15%), hemoglobin, iron, and transferrin. The RDW (%)/Hb (g/dL) ratio and tansferrin saturation (TSAT) were computed. The associations between RDW, RDW/Hb, TSAT, and the patients' clinical status were assessed. Results: In residents of Department A, RDW >15% was found in 33% of 19 stable patients, in 58% of 10 patients with intermediate severity, and in 81% of 10 patients classified severe-unstable. The RDW/Hb ratio >1.4 was found in 24% of stable patients, in 73% with intermediate severity, and in 93% of the severe-unstable patients. In Department B, 36 out of 38 patient's were classified stable: in 61.2 % the RDW was >15% and in 38% the RDW/Hb was >1.4. Conclusions: In a heterogenic population presenting multimorbidity, the RDW and to a higher degree the RDW/Hb (p <0.00001), correlated with the patients' disease severity.
背景:红细胞分布宽度(RDW)是衡量红细胞大小异质性的简单指标。在某些贫血中观察到高度的异细胞增多症,表现为RDW>15%,但在其他疾病中也观察到,其中RDW>115%与预后较差有关。我们质疑RDW/血红蛋白比率(RDW/Hb)是否比RDW更接近于疾病的严重程度。设计:横断面研究患者:76名住院医师两个科室的综合护理。方法:医生根据患者的临床状况将其分为三组:“稳定”、“严重不稳定”和“中等”。一名外部观察者从患者档案中提取RDW(如果>15%,则升高)、血红蛋白、铁和转铁蛋白的结果。计算RDW(%)/Hb(g/dL)比值和转铁蛋白饱和度(TSAT)。评估RDW、RDW/Hb、TSAT与患者临床状况之间的相关性。结果:在A科室的住院患者中,19名稳定患者中有33%的患者RDW>15%,10名中度患者中有58%的患者RDW>15%,而10名被归类为严重不稳定的患者中有81%的患者RDW/>15%。24%的稳定患者、73%的中度患者和93%的严重不稳定患者的RDW/Hb比值>1.4。在B科,38名患者中有36名病情稳定:61.2%的患者RDW>15%,38%的患者RDW/Hb>1.4。结论:在多发病的异质性人群中,RDW和更高程度的RDW/Hb(p<0.00001)与患者的疾病严重程度相关。
{"title":"Red Blood Cell Distribution Width/Hemoglobin Ratio Correlate with Severity of Clinical Status in Residents of Long-term Geriatric and Palliative Care","authors":"Jochanan E. Naschitz, Igor Yalonetzki, G. Leibovitz, Nathalia Zaigraykin","doi":"10.31579/2639-4162/038","DOIUrl":"https://doi.org/10.31579/2639-4162/038","url":null,"abstract":"Background: The red blood cell distribution width (RDW) is a simple measure of red blood cell size heterogeneity. A high degree of anisocytosis, expressed by RDW >15%, is observed in certain anemias, but also in other disorders, where RDW >15% is associated with worse prognosis. We questioned whether the RDW/hemoglobin ratio (RDW/Hb) might closer relate to disease severity than RDW. Design: Cross sectional study Patients: 76 residents of two Department of Comprehensive Nursing Care. Method: Physicians classified the patients according to their clinical status in three groups: \"stable\", “severe-unstable”, and \"intermediate\". An outside observer extracted from the patients' files the results of RDW (elevated if >15%), hemoglobin, iron, and transferrin. The RDW (%)/Hb (g/dL) ratio and tansferrin saturation (TSAT) were computed. The associations between RDW, RDW/Hb, TSAT, and the patients' clinical status were assessed. Results: In residents of Department A, RDW >15% was found in 33% of 19 stable patients, in 58% of 10 patients with intermediate severity, and in 81% of 10 patients classified severe-unstable. The RDW/Hb ratio >1.4 was found in 24% of stable patients, in 73% with intermediate severity, and in 93% of the severe-unstable patients. In Department B, 36 out of 38 patient's were classified stable: in 61.2 % the RDW was >15% and in 38% the RDW/Hb was >1.4. Conclusions: In a heterogenic population presenting multimorbidity, the RDW and to a higher degree the RDW/Hb (p <0.00001), correlated with the patients' disease severity.","PeriodicalId":93288,"journal":{"name":"General medicine and clinical practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42425946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Secrets of the Corona Virus: Gender Competition in Antibodies Production to Combat COVID-19 探索冠状病毒的秘密:对抗COVID-19抗体生产中的性别竞争
Pub Date : 2020-12-07 DOI: 10.31579/2639-4162/036
Hamzulla Khan
We did a pilot study in the month of July 2020 in Qazi Hussain Ahmed Medical complex Nowshera with aim to determine the gender protective role in term of production of neutralizing Anti SARS-COV-2 antibodies. A total of 39 COVID-19 patients with recovery were selected and their antibodies cut off values were measured by electro-chemiluminescence immunoassay using Roche Cobas E411 Chemistry Analyzer for which commercial kits of Roche diagnostics were used as per the instructions of the manufacturer. It was observed that Difference in mean post infection antibodies level was statistically significant with higher cut off values in patient who had symptoms at time of being reported positive by PCR as compared to patient who were asymptomatic (p-value:0.04). We predicted using Kaplan Meir that female gender the probability of survival as 70% in with cut off values of 100, while a vertical drop up to less than 20% probability of survival was predicted in male gender. Hence female gender produces higher level of antibodies in early infections to confer immunity in COVID-19.
2020年7月,我们在Qazi Hussain Ahmed医疗综合体Nowshera进行了一项试点研究,旨在确定在产生中和抗严重急性呼吸系统综合征冠状病毒2型抗体方面的性别保护作用。共选择39名新冠肺炎康复患者,并使用罗氏Cobas E411化学分析仪通过电化学发光免疫测定法测量他们的抗体截止值,根据制造商的说明使用罗氏诊断的商业试剂盒。观察到,感染后平均抗体水平的差异具有统计学意义,与无症状患者相比,在PCR报告阳性时有症状的患者的截断值更高(p值:0.04),而预测男性的存活概率垂直下降不到20%。因此,女性在早期感染中产生更高水平的抗体,从而赋予新冠肺炎免疫力。
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引用次数: 0
Possible Connection between High-Voltage Power Lines & Cancer 高压电线与癌症之间可能的连接
Pub Date : 2020-12-07 DOI: 10.31579/2639-4162/031
Paul T E Cusack
We have heard for years that there may be a connection between high voltage lines and cancer. Since my previous paper on Hydrogen Peroxide as a carcinogen, coupled with my equations of the mind, soul, and consciousness, I purpose a mathematical connection between Power lines and cancer. There should be safe distance to keep the magnetic field produced by the lines and the mind.
多年来我们一直听说高压线和癌症之间可能有联系。由于我之前关于过氧化氢是致癌物的论文,加上我关于思想、灵魂和意识的方程式,我打算在电力线和癌症之间建立数学联系。应该有一个安全的距离,以保持磁场产生的线路和思想。
{"title":"Possible Connection between High-Voltage Power Lines & Cancer","authors":"Paul T E Cusack","doi":"10.31579/2639-4162/031","DOIUrl":"https://doi.org/10.31579/2639-4162/031","url":null,"abstract":"We have heard for years that there may be a connection between high voltage lines and cancer. Since my previous paper on Hydrogen Peroxide as a carcinogen, coupled with my equations of the mind, soul, and consciousness, I purpose a mathematical connection between Power lines and cancer. There should be safe distance to keep the magnetic field produced by the lines and the mind.","PeriodicalId":93288,"journal":{"name":"General medicine and clinical practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47276789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous presentation of COVID-19 Case Report COVID-19病例的皮肤表现报告
Pub Date : 2020-12-07 DOI: 10.31579/2639-4162/041
Khadiga Ahmed Ismail, Mahmoud Khalifa Marzouq, Ahmed Mahmoud Khalifa, Osama Mahmoud Khalifa
COVID-19 has high transmissibility and infectivity among human. On January 30, 2020, the World Health Organization (WHO) in an effort to slow down the global spread of the virus declared the outbreak, “A global public health emergency of international concern". The skin manifestations of the novel coronavirus COVID-19 were not recognized at the early stages of the pandemic but have received much recent attention in scientific journals. Reported manifestations range from pseudo-chilblains to a morbilliform (measles-like) exanthem, urticaria, vesicular eruptions, a dengue-like petechial rash and ovate scaling macules, and plaques mimicking pityriasis rosea.
新冠肺炎在人群中具有较高的传播性和传染性。2020年1月30日,世界卫生组织(世界卫生组织)为减缓病毒在全球的传播,宣布疫情暴发,“国际关注的全球突发公共卫生事件”。新型冠状病毒新冠肺炎的皮肤表现在大流行的早期阶段没有被识别,但最近在科学期刊上受到了广泛关注。报告的表现从假感冒到麻疹(麻疹样)皮疹、荨麻疹、水泡性皮疹、登革热样瘀点皮疹和卵形鳞状斑,以及类似玫瑰糠疹的斑块。
{"title":"Cutaneous presentation of COVID-19 Case Report","authors":"Khadiga Ahmed Ismail, Mahmoud Khalifa Marzouq, Ahmed Mahmoud Khalifa, Osama Mahmoud Khalifa","doi":"10.31579/2639-4162/041","DOIUrl":"https://doi.org/10.31579/2639-4162/041","url":null,"abstract":"COVID-19 has high transmissibility and infectivity among human. On January 30, 2020, the World Health Organization (WHO) in an effort to slow down the global spread of the virus declared the outbreak, “A global public health emergency of international concern\". The skin manifestations of the novel coronavirus COVID-19 were not recognized at the early stages of the pandemic but have received much recent attention in scientific journals. Reported manifestations range from pseudo-chilblains to a morbilliform (measles-like) exanthem, urticaria, vesicular eruptions, a dengue-like petechial rash and ovate scaling macules, and plaques mimicking pityriasis rosea.","PeriodicalId":93288,"journal":{"name":"General medicine and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41911091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous presentation of COVID-19 Case Report COVID-19病例的皮肤表现报告
Pub Date : 2020-09-20 DOI: 10.31579/2639-4162/034
K. Ismail
COVID-19 has high transmissibility and infectivity among human. On January 30, 2020, the World Health Organization (WHO) in an effort to slow down the global spread of the virus declared the outbreak, “A global public health emergency of international concern". The skin manifestations of the novel coronavirus COVID-19 were not recognized at the early stages of the pandemic but have received much recent attention in scientific journals. Reported manifestations range from pseudo-chilblains to a morbilliform (measles-like) exanthem, urticaria, vesicular eruptions, a dengue-like petechial rash and ovate scaling macules, and plaques mimicking pityriasis rosea.
新冠肺炎在人群中具有较高的传播性和传染性。2020年1月30日,世界卫生组织(世界卫生组织)为减缓病毒在全球的传播,宣布疫情暴发,“国际关注的全球突发公共卫生事件”。新型冠状病毒新冠肺炎的皮肤表现在大流行的早期阶段没有被识别,但最近在科学期刊上受到了广泛关注。报告的表现从假感冒到麻疹(麻疹样)皮疹、荨麻疹、水泡性皮疹、登革热样瘀点皮疹和卵形鳞状斑,以及类似玫瑰糠疹的斑块。
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引用次数: 0
A Behavioral Learning Theory Public Health Promotion and Education Campaign Plan for COVID-19 基于行为学习理论的新冠肺炎公共健康促进教育活动方案
Pub Date : 2020-09-18 DOI: 10.31579/2639-4162/028
Lisa Marie Portugal
The article includes a COVID-19 public health promotion and education campaign plan to prompt change by applying major behavioral change principles and procedures. Best practices research to motivate, support, and sustain health behavior change includes the application of Behavioral Learning Theory when educating the public regarding COVID-19 health challenges. Topics evaluated include: (1) Behavioral Learning Theory, (2) 6-month timeline for accomplishing three COVID-19 public health communication objectives, and (3) SWOT analysis.
文章中还包括了运用主要的行为改变原则和程序,推动改变的新冠肺炎国民健康宣传教育计划。激励、支持和维持健康行为改变的最佳实践研究包括在教育公众了解COVID-19健康挑战时应用行为学习理论。评估的主题包括:(1)行为学习理论,(2)完成三项COVID-19公共卫生传播目标的6个月时间表,以及(3)SWOT分析。
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引用次数: 0
期刊
General medicine and clinical practice
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