The novel coronavirus has a significant impact on the routine clinical practice for cancer patients in China since December 2019. During the epidemic in mainland China, especially Wuhan, the intravenous chemotherapies of cancer patients were considerably delayed. Up to now, cancer patients throughout the world directly encounter similar obstacles. For patients who have the right to choose chemotherapeutic regimens with different administration routes, oral drugs can be considered to be applied. In this mini-review, oral chemotherapeutic drugs were compared with intravenous drugs in seven types of tumors. Accordingly, we intended to provide useful suggestions for clinicians to balance the benefits and risks of oral against intravenous chemotherapies and to choose properly substituted oral chemotherapeutic regimens for cancer patients amid the coronavirus disease 2019 (COVID-19) pandemic.
{"title":"Oral Versus Intravenous Chemotherapy in COVID-19 Epidemic","authors":"Bicheng Wang, Boya Xiao","doi":"10.54457/dr.202201001","DOIUrl":"https://doi.org/10.54457/dr.202201001","url":null,"abstract":"The novel coronavirus has a significant impact on the routine clinical practice for cancer patients in China since December 2019. During the epidemic in mainland China, especially Wuhan, the intravenous chemotherapies of cancer patients were considerably delayed. Up to now, cancer patients throughout the world directly encounter similar obstacles. For patients who have the right to choose chemotherapeutic regimens with different administration routes, oral drugs can be considered to be applied. In this mini-review, oral chemotherapeutic drugs were compared with intravenous drugs in seven types of tumors. Accordingly, we intended to provide useful suggestions for clinicians to balance the benefits and risks of oral against intravenous chemotherapies and to choose properly substituted oral chemotherapeutic regimens for cancer patients amid the coronavirus disease 2019 (COVID-19) pandemic.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"216 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72429273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boya Xiao, Zhan-jie Zhang, Bohua Kuang, Ru-bo Cao, Bicheng Wang
Concurrent chemoradiotherapy (CCRT) is the foundational standard-of-care for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). Adding adjuvant chemotherapy (AC) or induction chemotherapy (IC) to CCRT has been shown to benefit LANPC patients. During recent five years, large numbers of prospective randomized controlled clinical trials have demonstrated the superior efficacy of IC+CCRT than CCRT alone in LANPC patients. However, prospectively designed studies concerned with AC are limited. The efficacy of CCRT+AC in treating LANPC remains unclear. For better understanding and more properly clinical usages of AC, we reviewed the studies of CCRT+AC in the treatments for LANPC patients. In summary, adding AC to CCRT is a feasible therapeutic strategy for patients with EBV positive LANPC.
{"title":"Clinical Progress of Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma","authors":"Boya Xiao, Zhan-jie Zhang, Bohua Kuang, Ru-bo Cao, Bicheng Wang","doi":"10.54457/dr.202101001","DOIUrl":"https://doi.org/10.54457/dr.202101001","url":null,"abstract":"Concurrent chemoradiotherapy (CCRT) is the foundational standard-of-care for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). Adding adjuvant chemotherapy (AC) or induction chemotherapy (IC) to CCRT has been shown to benefit LANPC patients. During recent five years, large numbers of prospective randomized controlled clinical trials have demonstrated the superior efficacy of IC+CCRT than CCRT alone in LANPC patients. However, prospectively designed studies concerned with AC are limited. The efficacy of CCRT+AC in treating LANPC remains unclear. For better understanding and more properly clinical usages of AC, we reviewed the studies of CCRT+AC in the treatments for LANPC patients. In summary, adding AC to CCRT is a feasible therapeutic strategy for patients with EBV positive LANPC.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89463181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhijie Wang, Jianglong Kong, Ziteng Chen, Meiru Mao, Jiacheng Li, Hui Yuan, Ya-nan Chang, Kui Chen, Juan Li
Backgrounds: Surgery and chemotherapy are difficult because of the specific location of the glioma. The establishment of a suitable in situ model of glioma is the premise of the treatment of glioma. 8 week-old female BALB/c nude mice were chose to establish the glioma model. Methods: For the orthotopic glioma mice model, 1 × 105cells/5 μL U87-MG-Luc or U87-MG cells which were trypsinized and resuspended in sterile PBS were slowly injected into the right corpus striatum (1.8 mm lateral, 0.6 mm anterior to the bregma and 3.0 mm in depth) by a stereotactic fixation device using a mouse adaptor. Results: The othotopic U87 glioma mice model identified by imaging on IVIS Spectrum and magnetic resonance imaging after 2 weeks from surgery. H&E-stained tumor sections in brain of the mice model were also observed. Conclusions: After identification, the glioma mouse xenograft in situ model obtained could be used in the evaluation system of therapeutic drugs or methods.
{"title":"Human Glioma Nude Mouse Xenograft Model in situ","authors":"Zhijie Wang, Jianglong Kong, Ziteng Chen, Meiru Mao, Jiacheng Li, Hui Yuan, Ya-nan Chang, Kui Chen, Juan Li","doi":"10.54457/dr.202101003","DOIUrl":"https://doi.org/10.54457/dr.202101003","url":null,"abstract":"Backgrounds: Surgery and chemotherapy are difficult because of the specific location of the glioma. The establishment of a suitable in situ model of glioma is the premise of the treatment of glioma. 8 week-old female BALB/c nude mice were chose to establish the glioma model. Methods: For the orthotopic glioma mice model, 1 × 105cells/5 μL U87-MG-Luc or U87-MG cells which were trypsinized and resuspended in sterile PBS were slowly injected into the right corpus striatum (1.8 mm lateral, 0.6 mm anterior to the bregma and 3.0 mm in depth) by a stereotactic fixation device using a mouse adaptor. Results: The othotopic U87 glioma mice model identified by imaging on IVIS Spectrum and magnetic resonance imaging after 2 weeks from surgery. H&E-stained tumor sections in brain of the mice model were also observed. Conclusions: After identification, the glioma mouse xenograft in situ model obtained could be used in the evaluation system of therapeutic drugs or methods.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76324470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Gao, Ling Xu, Xiangying Zhang, Zhihao Fan, Huanhu Zhang, Z. Duan, F. Ren
Backgrounds: Despite passive and active immunization, perinatal mother-to-infant transmission (MTIT) of hepatitis B virus (HBV) still occurs in women with high levels of viremia. Thus, understanding the mechanisms of MTIT is essential to prevent MTIT. The aims of this study were to clarify the roles of toll-like receptor 3 (TLR3) in the prevention of hepatitis B transmission in mothers with a high viral load. Methods: Placental samples were collected from 87 HBV-positive pregnant women and 25 normal pregnant women. Choriocarcinoma JEG-3 cell lines were exposed to different HBV viral loads to mimic the trophoblast barrier affected by HBV in the placenta. The mRNA and protein expression levels of TLR3 were analyzed by qRT-PCR and western blotting assays in placenta and JEG-3 cells, respectively. Results: In terms of mRNA and protein expression, the expression of TLR3 in the placenta among the control, low viral load, medium viral load and high viral load groups were significantly different, showing significant upregulation in the medium load and high load groups compared with the control; TLR3 expression in the placenta of the HBeAg-positive group was higher than that in the HBeAg-negative group, and TLR3 expression in the placenta of the infant-infected group was lower than that of the infant-noninfected group. Expression of TLR3 was gradually increased in JEG-3 cells exposed to low HBV viral loads or with shortterm HBV exposure and was decreased in JEG-3 cells exposed to high HBV viral loads or with longterm HBV exposure. Conclusions: TLR3 contribute to HBV intrauterine infection in mothers with a high viral load and, importantly, prevents mother-to-infant transmission.
{"title":"Roles of Toll-like Receptor 3 in Intrauterine Transmission of Hepatitis B Virus in Mothers with High Viral Load","authors":"Hong Gao, Ling Xu, Xiangying Zhang, Zhihao Fan, Huanhu Zhang, Z. Duan, F. Ren","doi":"10.54457/dr.202101002","DOIUrl":"https://doi.org/10.54457/dr.202101002","url":null,"abstract":"Backgrounds: Despite passive and active immunization, perinatal mother-to-infant transmission (MTIT) of hepatitis B virus (HBV) still occurs in women with high levels of viremia. Thus, understanding the mechanisms of MTIT is essential to prevent MTIT. The aims of this study were to clarify the roles of toll-like receptor 3 (TLR3) in the prevention of hepatitis B transmission in mothers with a high viral load. Methods: Placental samples were collected from 87 HBV-positive pregnant women and 25 normal pregnant women. Choriocarcinoma JEG-3 cell lines were exposed to different HBV viral loads to mimic the trophoblast barrier affected by HBV in the placenta. The mRNA and protein expression levels of TLR3 were analyzed by qRT-PCR and western blotting assays in placenta and JEG-3 cells, respectively. Results: In terms of mRNA and protein expression, the expression of TLR3 in the placenta among the control, low viral load, medium viral load and high viral load groups were significantly different, showing significant upregulation in the medium load and high load groups compared with the control; TLR3 expression in the placenta of the HBeAg-positive group was higher than that in the HBeAg-negative group, and TLR3 expression in the placenta of the infant-infected group was lower than that of the infant-noninfected group. Expression of TLR3 was gradually increased in JEG-3 cells exposed to low HBV viral loads or with shortterm HBV exposure and was decreased in JEG-3 cells exposed to high HBV viral loads or with longterm HBV exposure. Conclusions: TLR3 contribute to HBV intrauterine infection in mothers with a high viral load and, importantly, prevents mother-to-infant transmission.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85019468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/idr2021o0208001
Xiankun Wang, X. Ren, Liuluan Zhu, Zhihai Chen
{"title":"The significance of the potential link between thrombocytopenia and NETs in COVID-19 should not be ignored","authors":"Xiankun Wang, X. Ren, Liuluan Zhu, Zhihai Chen","doi":"10.53388/idr2021o0208001","DOIUrl":"https://doi.org/10.53388/idr2021o0208001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/tmr2021t0127001
Yan Wang, Yueying Zhang, Wanying Zhang, Guo-wei Zhang
An article by Omara Dogar et al [1]. that was first published in Lancet Global Health in 2020 revealed that current evidence didn’t support the addition of cytisine to brief behavioural support for the treatment of tobacco dependence in patients with tuberculosis. Tuberculosis is one of the most common chronic infectious diseases in the world. An estimated 10 million people suffering from tuberculosis and around 7.1 million new TB cases worldwide were officially notified to national authorities in 2019. Geographically, the majority of TB cases in 2019 were concentrated in Southeast Asia (44%), Africa (25%), the Western Pacific (18%), while the Eastern Mediterranean (8.2%), the Americas (2.9%) and Europe (2.5%) accounted for a smaller proportion. In 2017, about 85% of tuberculosis deaths occurred in Africa and southeast Asia where the prevalence of smoking is high [2]. In 2019, the number of cases of tuberculosis in China was about 775,764, and the death toll was about 2,990. Smoking has gradually become one of the important causes of death from tuberculosis [3]. Smoking seriously affects human health, especially those patients with tuberculosis. The smoke produced by smok-
{"title":"The effect of cytisine on smoking cessation in patients with pulmonary tuberculosis","authors":"Yan Wang, Yueying Zhang, Wanying Zhang, Guo-wei Zhang","doi":"10.53388/tmr2021t0127001","DOIUrl":"https://doi.org/10.53388/tmr2021t0127001","url":null,"abstract":"An article by Omara Dogar et al [1]. that was first published in Lancet Global Health in 2020 revealed that current evidence didn’t support the addition of cytisine to brief behavioural support for the treatment of tobacco dependence in patients with tuberculosis. Tuberculosis is one of the most common chronic infectious diseases in the world. An estimated 10 million people suffering from tuberculosis and around 7.1 million new TB cases worldwide were officially notified to national authorities in 2019. Geographically, the majority of TB cases in 2019 were concentrated in Southeast Asia (44%), Africa (25%), the Western Pacific (18%), while the Eastern Mediterranean (8.2%), the Americas (2.9%) and Europe (2.5%) accounted for a smaller proportion. In 2017, about 85% of tuberculosis deaths occurred in Africa and southeast Asia where the prevalence of smoking is high [2]. In 2019, the number of cases of tuberculosis in China was about 775,764, and the death toll was about 2,990. Smoking has gradually become one of the important causes of death from tuberculosis [3]. Smoking seriously affects human health, especially those patients with tuberculosis. The smoke produced by smok-","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70822298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/idr2020a0927001
A. Ranjbar, S. Torabi, D. Nematollahi, M. Jamshidi, H. Ghasemi
{"title":"Molecular Modelling of the Therapeutic agents for COVID-19 Treatment","authors":"A. Ranjbar, S. Torabi, D. Nematollahi, M. Jamshidi, H. Ghasemi","doi":"10.53388/idr2020a0927001","DOIUrl":"https://doi.org/10.53388/idr2020a0927001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/idr2021a1011015
Pengcheng Zhou, Wei Yu
{"title":"Use of bronchoscopy-guided treatment and oral posaconazole to treat pulmonary mucormycosis: a case report and literature review","authors":"Pengcheng Zhou, Wei Yu","doi":"10.53388/idr2021a1011015","DOIUrl":"https://doi.org/10.53388/idr2021a1011015","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/idr2021a0816001
X. Ren, Xiankun Wang, Z. Ge, S. Cui, Zhihai Chen
{"title":"Laboratory indicators of death in severe fever with thrombocytopenia syndrome: a meta-analysis and systematic review","authors":"X. Ren, Xiankun Wang, Z. Ge, S. Cui, Zhihai Chen","doi":"10.53388/idr2021a0816001","DOIUrl":"https://doi.org/10.53388/idr2021a0816001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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