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What Factors can have an impact on the wound Healing Process from an oral surgery perspective? A Review 从口腔外科角度看,哪些因素会影响伤口愈合过程?综述
Pub Date : 2024-02-09 DOI: 10.58624/svoade.2024.05.0167
Salvatore Luca La Terra
Wound healing is a complex and dynamic process that involves a series of intricately regulated phases, each contributing to the restoration of tissue integrity. This comprehensive review dives into the fundamental aspects of wound healing, exploring the physiological mechanisms, phases, and influencing factors. The review begins with describing the significance of wound healing and navigates through sequential phases, such as hemostasis and inflammation, proliferation, remodelling, wound classification and closure techniques, thus providing insights into the diverse strategies employed in clinical settings. Much focus lies to bone healing, addressing both primary and secondary healing mechanisms, as well as the bone healing in extraction sockets. A significant segment of the review explores the factors affecting wound healing, which are categorized into local, surgical, and systemic factors encompassing ageing, diabetes mellitus, hormonal changes, immunocompromised conditions, medications, smoking, alcohol consumption, obesity, and nutrition deficiency. A synthesis of the reviewed content highlights the interplay of these factors in the ‘wound healing’ process. Understanding these elements is imperative for clinicians and researchers alike to develop effective therapeutic interventions tailored to individual patient needs. This review serves as a valuable resource for those seeking a comprehensive understanding of the intricate dynamics of wound healing in the human body.
伤口愈合是一个复杂而动态的过程,涉及一系列错综复杂的调节阶段,每个阶段都有助于恢复组织的完整性。本综述深入探讨了伤口愈合的基本问题,探讨了伤口愈合的生理机制、阶段和影响因素。综述从描述伤口愈合的意义开始,依次介绍了止血和炎症、增殖、重塑、伤口分类和闭合技术等阶段,从而为临床上采用的各种策略提供了深入的见解。该书的重点在于骨愈合,探讨了原发性和继发性愈合机制,以及拔牙窝的骨愈合。综述的很大一部分内容探讨了影响伤口愈合的因素,这些因素分为局部因素、手术因素和全身因素,其中包括年龄增长、糖尿病、激素变化、免疫力低下、药物、吸烟、饮酒、肥胖和营养不良。综述了所审查的内容,强调了这些因素在 "伤口愈合 "过程中的相互作用。临床医生和研究人员必须了解这些因素,才能根据患者的不同需求制定有效的治疗干预措施。这篇综述为寻求全面了解人体伤口愈合的复杂动态的人士提供了宝贵的资源。
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引用次数: 0
Socket Preservation Technique Using Resorbable Collagen Membrane v/s High Density d-PTFE Membrane: A Must in today’s Implant Rehabilitations. A Literature Review and 2 Clinical Cases Report. 使用可吸收胶原膜与高密度 d-PTFE 膜的牙槽窝保存技术:当今种植修复的必备技术。文献综述和两个临床病例报告。
Pub Date : 2024-01-29 DOI: 10.58624/svoade.2024.05.0165
Carine Tabarani
Following tooth extraction, resorption in alveolar bone results in narrowing of remaining ridge in the extraction site leading to compromised functional and aesthetic outcomes. The overall goal of the present article is to shed light on the importance of the socket preservation procedure in preserving the original bone dimensional contours, while comparing two essential approaches, using non-resorbable high density d-PTFE membranes v/s the non-cross linked collagen resorbable membranes, by assessing the clinical results in terms of regenerated bone volume, postoperative complications and evaluation of keratinized tissue in grafted areas with either one of the above mentioned membranes.
拔牙后,牙槽骨的吸收会导致拔牙部位的剩余牙脊变窄,从而影响功能和美观。本文的总体目标是阐明牙槽窝保存术在保留原有骨质尺寸轮廓方面的重要性,同时比较两种基本方法,即使用不可吸收的高密度 d-PTFE 膜与不可交联的胶原可吸收膜,通过评估再生骨量、术后并发症以及使用上述任一种膜移植区域角化组织的临床结果来说明这一点。
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引用次数: 0
Periodontal Treatment Improves Dyspepsia caused by Erosive Gastritis: A Case Report 牙周治疗可改善侵蚀性胃炎引起的消化不良:病例报告
Pub Date : 2024-01-12 DOI: 10.58624/svoade.2024.05.0163
I. Pedron, Thais Cordeschi, João Marcelo Ferreira de Medeiros, Luciano Mayer
Dyspepsia is a condition resulting from problems related to poor digestion and changes in the sensitivity of the stomach mucosa. It is usually related to diseases such as gastritis, gastroesophageal reflux disease, peptic ulcer and neoplasms of the upper gastrointestinal tract. Dyspepsia is strongly related to the presence of Helicobacter pylori bacteria. Dyspepsia is characterised by pain, pyrosis (heartburn or a burning sensation), anorexia (loss of appetite), abdominal distention, gastric bloating, eructation, flatulence, nausea and a feeling of satiety. Fantogeusia (bitter taste) and halitosis can also be observed. The purpose of this article is to present the case of a patient with dyspepsia caused by erosive gastritis. After periodontal treatment and control of the periodontal disease, an improvement in the symptoms of dyspepsia was reported.
消化不良是一种因消化不良和胃黏膜敏感性改变引起的疾病。它通常与胃炎、胃食管反流病、消化性溃疡和上消化道肿瘤等疾病有关。消化不良与幽门螺旋杆菌的存在密切相关。消化不良的特征是疼痛、胃灼热(烧心或灼烧感)、厌食(食欲不振)、腹胀、胃胀气、呃逆、胀气、恶心和饱腹感。此外,还可能出现苦味和口臭。本文旨在介绍一名因糜烂性胃炎引起消化不良的患者的病例。经过牙周治疗和牙周病控制后,消化不良的症状有所改善。
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引用次数: 0
Comparative Assessment of Octenidine and Chlorhexidine Mouthwash in Gingivitis and Periodontitis Patient: A Clinical Trial 牙龈炎和牙周炎患者使用奥替尼啶和洗必泰漱口水的比较评估:临床试验
Pub Date : 2023-12-12 DOI: 10.58624/svoade.2023.04.0162
Background: A common and tried-and-true ingredient in mouthwashes that works well against the development of plaque, gingivitis, and oral microbial growth is chlorhexidine gluconate (CHX). However, when it must be taken for an extended period of time, its benefits are limited by the accompanying side effects, which include taste modification, cytotoxicity, supragingival calculus formation, mucosal irritation, and tooth discoloration. In the 1980s, octenidine dihydrochloride (OCT), a new antibacterial cationic surfactant molecule, was produced at the Sterling-Winthrop Research Institute in Rensselaer, NY. OCT binds to negatively charged microbial surfaces and has a strong adherence to lipid components, which causes disruption of the cell membrane of bacteria, yeast, and fungus. Aim: The purpose of the study was to evaluate the efficacy of mouthwashes with 0.1% octenidine and 0.2% chlorhexidine in patients with gingivitis and periodontitis. Material and Method: Participants in this clinical experiment were split into two groups, each consisting of forty patients with periodontitis and gingivitis. Next, as an addition to scaling and root planning (SRP), 20 patients from each group were provided chlorhexidine mouthwash and 20 patients were recommended to use octenidine mouthwash. At baseline and three months later, clinical measures such as the O’Leary plaque index (PI), bleeding index, probing pocket depth (POD), and clinical attachment loss (CAL) were assessed. Result: All clinical measurements showed that the Octenidine group performed much better than the chlorhexidine group in both the gingivitis and periodontitis groups. Conclusion: When compared to chlorhexidine, Octenidine performed better across all of the previously listed clinical parameters. As a result, it can be regarded as a promising mouthwash for upcoming medical and scientific investigations.
背景:葡萄糖酸氯己定(CHX)是漱口水中一种常见的、久经考验的成分,对牙菌斑、牙龈炎和口腔微生物生长有良好的抑制作用。但是,如果必须长期使用,其功效就会受到随之而来的副作用的限制,包括味道改变、细胞毒性、龈上结石形成、粘膜刺激和牙齿变色。20 世纪 80 年代,位于纽约州伦斯勒的斯特林-温特洛普研究所生产出一种新型抗菌阳离子表面活性剂分子--盐酸辛烯胺(OCT)。OCT 能与带负电荷的微生物表面结合,并对脂质成分有很强的附着力,从而破坏细菌、酵母菌和真菌的细胞膜。目的:本研究旨在评估 0.1% 辛烯胺和 0.2% 洗必泰漱口水对牙龈炎和牙周炎患者的疗效。材料和方法:临床实验参与者分为两组,每组由 40 名牙周炎和牙龈炎患者组成。然后,作为洗牙和牙根规划(SRP)的补充,每组 20 名患者使用洗必泰漱口水,20 名患者建议使用辛烯胺漱口水。在基线和三个月后,对临床指标进行评估,如奥利里牙菌斑指数(PI)、出血指数、探诊袋深度(POD)和临床附着丧失(CAL)。结果所有临床测量结果显示,无论是牙龈炎组还是牙周炎组,奥克替尼组的表现都比洗必泰组好得多。结论与洗必泰相比,奥克替尼在前面列出的所有临床参数中均表现更佳。因此,奥克替尼是一种很有前途的漱口水,可用于今后的医学和科学研究。
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引用次数: 0
Robotic Applications in Orthodontics: Overview of Existing Research 正畸学中的机器人应用:现有研究概述
Pub Date : 2023-12-08 DOI: 10.58624/svoade.2023.04.0161
Sachin Philip, Varun Goyal, Gurkeerat Singh, S. Kannan, R. Singh, Ankit Chaudari, Triparna Kapoor
Malocclusion is the world's third most common oral ailment. The fixed orthodontic procedure is now the most successful treatment strategy for malocclusion. Archwire bending is an important part of orthodontic therapy. However, because to the great stiffness and exceptional flexibility of orthodontic wire, it is a very difficult task. The old method of obtaining the created archwire curve is dependent on manual operation, which would bring various errors induced by human causes. Customised archwires are required in clinics for lingual orthodontics treatment. Previously, only expert orthodontists could physically bend these archwires. This is a pattern demands specialised skill training, precision, and extensive chairside time, but cannot guarantee the accuracy of appliances. So, what are the most recent developments?
错颌畸形是全球第三大常见口腔疾病。固定正畸是目前治疗错颌畸形最成功的方法。弓丝弯曲是正畸治疗的重要组成部分。然而,由于正畸钢丝具有很高的硬度和特殊的柔韧性,因此这是一项非常困难的任务。获得弓丝曲线的旧方法依赖于手工操作,这会带来各种人为误差。在诊所进行舌侧正畸治疗时,需要定制弓丝。以前,只有专业的正畸医生才能用物理方法弯曲弓丝。这种模式需要专业的技能培训、精确度和大量的椅旁时间,但却无法保证矫治器的准确性。那么,最新的发展是什么呢?
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引用次数: 0
Advancing Oro-Dental and Cranio-Maxillo-Facial Interventions for QoL: Injectable Hydrogel and BioCeramic NanoDelivery Platforms 推进口腔颌面介入治疗,提高生活质量:注射水凝胶和生物陶瓷纳米给药平台
Pub Date : 2023-11-29 DOI: 10.58624/svoade.2023.04.0159
Ziyad S. Haidar
In the ever-evolving landscape of healthcare, where science, technology, and clinical practice converge, the realm of cranio-maxillo-facial and oro-dental interventions stands at the forefront of transformative possibilities. This communication embarks on an illuminating journey into the heart of this dynamic field, where innovation knows no bounds. Collaborative student engagement has been instrumental in not only exploring but also bridging the chasm between diverse scientific disciplines and the practical intricacies of clinical application. Recent strides in drug delivery mechanisms, characterized by the ingenious fusion of cells and nano-carriers, have laid the foundation for a revolution in regenerative medicine. These breakthroughs promise a future where treatments are not only precise but also meticulously controlled, enhancing patient quality of life through the amelioration of disease conditions and restoration of bodily functions. Injectable hydrogels, another trailblazing innovation, have emerged as a beacon of hope. They offer versatile solutions that promise to redefine surgical and clinical practices by affording healthcare professionals spatio-temporal control, tunability, and stimuli-responsiveness. These hydrogels unlock the potential for the targeted delivery of therapeutic agents, including cells, genes, proteins, and drugs, revolutionizing tissue engineering, regenerative medicine, and aesthetic surgical interventions. BioCeramics, a burgeoning field, is redefining conventional wisdom in bone grafting and implant technology. These biomaterials are poised to usher in a new era of innovative approaches that enhance the mechanical and biological compatibility of implants, facilitating improved clinical outcomes and patient quality of life. Moreover, this communication serves as a herald of exciting news: the inauguration of a Doctoral (PhD) Program in Dental Sciences at the prestigious Universidad de los Andes in Santiago de Chile. This program beckons forward-thinkers, visionaries, and emerging scholars to partake in pioneering research at the Laboratorio de Biomateriales, Farmace uticos y Bioingenierí a de Tejidos Cra neo Ma xilo-Facial. As we embrace the future, limitless possibilities abound in this transformative health field, where advancing science and technology merge seamlessly to enhance the clinical and surgical armamentarium available for contemporary practices and users. This journey represents not only a dedication to scientific exploration yet an unwavering commitment to improving patient quality of life (QoL) and well-being thru the amalgamation of cutting-edge research, innovation, and compassionate care.
在不断发展的医疗保健领域,科学、技术和临床实践相互交融,颅颌面和口腔干预领域正处于变革的最前沿。这篇通讯开启了一段富有启发性的旅程,让我们走进这个创新无止境、充满活力的领域。学生的合作参与不仅有助于探索,也有助于弥合不同科学学科与错综复杂的临床应用之间的鸿沟。最近,以细胞和纳米载体的巧妙融合为特征的给药机制取得了长足进步,为再生医学的革命奠定了基础。这些突破预示着,未来的治疗不仅精确,而且控制细致,通过改善疾病状况和恢复身体功能来提高病人的生活质量。可注射水凝胶是另一项开拓性创新,已成为希望的灯塔。它们提供了多功能解决方案,通过为医护人员提供时空控制、可调性和刺激反应性,有望重新定义外科和临床实践。这些水凝胶释放了靶向输送治疗剂(包括细胞、基因、蛋白质和药物)的潜力,彻底改变了组织工程、再生医学和美容手术干预。生物陶瓷是一个新兴领域,正在重新定义骨移植和植入技术的传统智慧。这些生物材料有望开创创新方法的新时代,提高植入物的机械和生物兼容性,促进临床效果和患者生活质量的改善。此外,这篇通讯还预示着一个振奋人心的消息:智利圣地亚哥著名的安第斯大学(Universidad de los Andes)将开设牙科学博士(PhD)课程。该项目召唤着那些具有前瞻性思维、远见卓识和新兴学者,让他们参与到克拉尼奥马西洛-面部生物材料、农场和生物工程实验室的开拓性研究中来。在我们拥抱未来的过程中,这一变革性的健康领域蕴含着无限的可能性,不断进步的科学与技术在这里完美融合,为当代的临床实践和用户提供了更多的临床和外科手术手段。这一历程不仅代表着我们对科学探索的执着,也代表着我们对通过融合尖端研究、创新和爱心护理来提高患者生活质量(QoL)和福祉的坚定承诺。
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引用次数: 0
Application of Recombinant Human Bone Morphogenetic Protein-2 (RhBMP-2) in the Reconstruction of Edentulous Posterior Maxilla: Clinical Protocol, Histological Analysis, and Long-Term Implant Success and Survival Rates 重组人骨形态发生蛋白-2 (RhBMP-2)在无牙颌后上颌骨重建中的应用:临床方案、组织学分析及长期植入成功率和存活率
Pub Date : 2023-11-29 DOI: 10.58624/svoade.2023.04.0160
G. Deryabin, S. Grybauskas, Tadas Korzinskas
Background: This study evaluated the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) in inducing de novo bone formation during the augmentation of the severely resorbed posterior maxilla for dental implant placement. Methods: Composite grafts consisting of rhBMP-2/absorbable collagen sponge (ACS) mixed with deproteinized bovine bone mineral (DBBM) Bio-Oss in a 1:1 ratio were used to reconstruct severely resorbed posterior maxillae in 13 patients (five men, eight women; age range: 50 to 66 years). Three patients were treated with sinus floor augmentation alone, and 10 patients with a combination of sinus floor augmentation and guided bone regeneration. A total of 71 dental implants were used in this study. The residual bone height below the maxillary sinus ranged from 0.5 to 3.0 mm. Clinical, radiological, and histomorphometric analyses were performed to assess the outcomes of bone augmentation. Results: The healing period was uneventful in all patients. The mean alveolar ridge height increased by 14 mm (range, 10–18 mm) and the mean alveolar width increased by 6 mm (range, 4–7 mm). Histopathological analysis revealed that newly formed bone was detectable throughout the implantation sites of sinus biopsies. The analysis of vascularization of the implant bed revealed large numbers of high-lumen vessels, in addition to moderate numbers of smaller blood vessels within the connective tissue. The histomorphometrical analysis of the tissue distribution showed that the amount of newly formed bone was 20.39 ± 4.95%, the amount of the remaining bone substitute was 41.85 ± 11.97%, and connective tissue was 37.76 ± 8.82%. The overall dental implant success and survival rates were 100% and remained unchanged at a follow-up period of 3 to 12 years. Conclusions: The results of this study demonstrated that a composite graft of rhBMP-2/ACS and DBBM can result in predictable reconstruction of a large bone volume of the maxilla for dental implant placement and functional loading.
背景:本研究评估了重组人骨形态发生蛋白-2(rhBMP-2)在上颌骨后部严重吸收的牙种植体植入增量过程中诱导新生骨形成的功效。方法:使用由 rhBMP-2/可吸收胶原海绵(ACS)与去蛋白牛骨矿物质(DBBM)Bio-Oss 以 1:1 的比例混合而成的复合移植物,对 13 名患者(5 名男性,8 名女性;年龄范围:50 至 66 岁)严重吸收的后上颌骨进行重建。其中 3 名患者仅接受了上颌窦底隆起术,10 名患者接受了上颌窦底隆起术和引导骨再生术的联合治疗。本研究共使用了 71 个牙科植入物。上颌窦下方的残余骨高度从 0.5 毫米到 3.0 毫米不等。研究人员进行了临床、放射学和组织形态计量学分析,以评估骨增量的效果。结果:所有患者的愈合过程都很顺利。平均牙槽嵴高度增加了 14 毫米(范围为 10-18 毫米),平均牙槽宽度增加了 6 毫米(范围为 4-7 毫米)。组织病理学分析表明,在窦活检的种植部位都能检测到新形成的骨。对种植床血管化的分析表明,除了结缔组织内中等数量的较小血管外,还有大量的高腔血管。组织分布的组织形态学分析表明,新形成的骨量为 20.39 ± 4.95%,剩余骨替代物为 41.85 ± 11.97%,结缔组织为 37.76 ± 8.82%。种植牙的总体成功率和存活率均为 100%,并且在 3 至 12 年的随访期间保持不变。结论:这项研究结果表明,rhBMP-2/ACS 和 DBBM 的复合移植可以为种植体植入和功能性负荷重建上颌骨的大量骨量,效果是可以预测的。
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引用次数: 0
The Liquid Dentist 液体牙医
Pub Date : 2023-11-17 DOI: 10.58624/svoade.2023.04.0158
Irineu Gregnanin Pedron
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引用次数: 0
Dentinogenic Ghost Cell Tumor: An Unusual Aggressive Oral Lesion 牙本质源性鬼细胞瘤:一种罕见的侵袭性口腔病变
Pub Date : 2023-11-10 DOI: 10.58624/svoade.2023.04.0157
Thomas Borris, Ogden Deaton, Jane Chang, Samia Nawaz
The purpose of this report was to document a case with a 1-week and 2-month follow up and contribute to the small body of existing literature to better understand this rare odontogenic tumor. There have been few aggressive and large dentinogenic ghost cell tumor case reports found in this literature.
本报告的目的是通过1周2个月的随访记录一个病例,并有助于现有文献的一小部分,以更好地了解这种罕见的牙源性肿瘤。在这方面的文献中很少发现侵袭性和大的牙本质源性鬼细胞瘤病例报告。
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引用次数: 0
Comparing the Incidence of Dental Defects in Oval Root Canals Prepared with Two Distinct Endodontic Rotary Files: An In Vitro Study 两种不同根管旋转锉制备的椭圆根管缺损发生率的比较:一项体外研究
Pub Date : 2023-11-09 DOI: 10.58624/svoade.2023.04.0156
Harsha Pujari, Preetpal Sandhu
Objective: The purpose of this work is to compare the incidence of dentinal defects in oval root canals with two different file systems and examine and contrast the creation of dentinal cracks using a scanning electron microscope (SEM) and a stereomicroscope during the root canal preparation process. Material and Method: Three groups of 15 were created from the sixty extracted human mandibular premolars: two were experimental and one was control. The experimental groups underwent root canal therapy. Group I the control group, did not receive any preparations. Group II is the Waldent walflex file and group III is the Trunatomy (TRN) file. After sectioning the roots at 3, 6, and 9 mm from the apex, the surfaces were examined with a stereomicroscope and SEM. Results: The data were examined using the Chi-square test. There were no fissures in the untreated group. The area between 3mm and 6mm was where the cracks in Waldent Walflex were most evident. There was no statistically significant difference between the experimental groups at either the 6 mm or 9 mm levels (P > 0.05). Conclusion: In conclusion, each rotary file utilized in the testing caused dentinal cracks. Compared to the Trunatomy file group, the Waldent walflex file group has more errors. The apical area of the samples had much more defects than the median and coronal regions.
目的:比较两种不同锉制下椭圆根管内牙本质缺损的发生率,并利用扫描电镜和体视显微镜观察和对比根管预备过程中牙本质裂纹的形成情况。材料与方法:以60颗人下颌前磨牙为材料,制作3组,每组15颗,2组为实验组,1组为对照组。实验组接受根管治疗。第一组为对照组,不接受任何制剂。第二组是Waldent walflex文件,第三组是Trunatomy (TRN)文件。在离根尖3、6和9 mm处切片后,用体视显微镜和扫描电镜观察根的表面。结果:数据采用卡方检验。未治疗组无骨裂。Waldent Walflex的裂缝在3mm到6mm之间的区域最为明显。在6 mm和9 mm水平上,实验组之间无统计学差异(P >0.05)。结论:试验中使用的每一种旋转锉均造成牙本质裂纹。与Trunatomy文件组相比,Waldent walflex文件组有更多的错误。样品的根尖区比中位区和冠状区有更多的缺陷。
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引用次数: 0
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SVOA Dentistry
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