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Infectious Endocarditis with Major Cutaneous Expression: About A Case 以皮肤为主表现的感染性心内膜炎1例
Pub Date : 2021-09-25 DOI: 10.36502/2021/ASJBCCR.6248
S. Beye, Cheikh Samb, Khadimu Rassoul DIOP, Ansoumana Condé, J. Mingou, Jean Mathieu Sy, A. Kane
Introduction: Infectious endocarditis is a transplant of microorganisms in healthy endocardium, in injured endocardium or intracardiac material. The modes of revelation can be multiple and varied, the skin manifestations of an infectious although classical endocarditis, are rare.Observation: This was a young 20-year-old patient, admitted in our cardiac unit for the exploration of a cardiac murmur in a context of long-term fever evolving for nearly 3 weeks associated with a skin rash. The examination found fever at 39°C and tachycardia at 115 beats/min. The cardiac auscultation revealed tachycardia with a systolic breath apexian mitral insufficiency. The skin examination revealed Osler’s nodules, an erythema of Janeway on the soles of the feet and on the palms of the hands. In biology, there was a non-specific biological inflammatory syndrome. Blood cultures from three series of samples did not isolate a germ. The transthoracic echography showed large vegetations in the anterior and posterior leaflets of mitral valve associated with severe mitral regurgitation. In this context, the diagnosis of mitral endocarditis is retained according to the Duke criteria. A double intravenous antibiotic therapy based on ceftriaxone and gentamycin was administrated. The evolution was favorable with stable apyrexia, disappearance of skin signs, regression of non-specific biological inflammatory syndrome. A replacement surgery of mitral valve was proposed.Conclusion: Infectious endocarditis is a disease with multiple and varied modes of revelation. Although skin manifestations are rare, they are still a determining factor in the diagnosis of infectious endocarditis.
感染性心内膜炎是微生物在健康心内膜、损伤心内膜或心内物质中的移植。揭示的模式可以是多种多样的,皮肤表现传染性虽然经典的心内膜炎,是罕见的。观察:这是一名20岁的年轻患者,因心脏杂音入院,长期发烧近3周并伴有皮疹。检查发现发热39℃,心动过速115次/分。心脏听诊显示心动过速伴收缩期呼吸尖顶性二尖瓣功能不全。皮肤检查发现奥斯勒结节,这是一种在脚底和手掌上的珍妮韦红斑。在生物学上,有一种非特异性的生物炎症综合征。三个系列样本的血液培养没有分离出细菌。经胸超声检查显示二尖瓣前后叶大片植被伴严重的二尖瓣返流。在这种情况下,二尖瓣心内膜炎的诊断保留根据杜克标准。给予头孢曲松和庆大霉素双静脉抗生素治疗。进化是有利的,稳定的食欲,皮肤症状消失,非特异性生物炎症综合征的消退。提出一种二尖瓣置换术。结论:感染性心内膜炎是一种表现形式多样的疾病。虽然皮肤表现是罕见的,他们仍然是诊断感染性心内膜炎的决定性因素。
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引用次数: 0
Current Data on Lower Prevalence and Age-Related Aggravation of COVID-19 in Japan 日本新冠肺炎低患病率和年龄相关加重的最新数据
Pub Date : 2021-08-15 DOI: 10.36502/2021/asjbccr.6246
H. Bando
Pandemic COVID-19 has been crucial problem worldwide, and authors have reported less prevalence and excess death in Japan. The Ministry of Health, Labour and Welfare of Japan presented COVID-report of July 2021 Edition. Among them, the number of people diagnosed with COVID-19 in Japan was 796,835 until July 1, 2021, which is equivalent to 0.6% of the total population. Aggravation rate of COVID-19 increases remarkably with aging. The result shows 1, 4, 10, 25, 47, 70< in 30s, 40s, 50s, 60, 70s, 80s< years old, respectively. In contrast, it shows 0.5, 0.2, 0.3 in <9, 10-19, 20-29 years, respectively.
大流行性新冠肺炎一直是世界范围内的关键问题,作者报告日本的流行率较低,死亡人数过多。日本厚生劳动省提交了2021年7月版的新冠肺炎报告。其中,截至2021年7月1日,日本确诊感染新冠肺炎的人数为796835人,相当于总人口的0.6%。新冠肺炎加重率随年龄增长而显著增加。结果表明:30s、40s、50s、60s、70s、80s年龄分别为1岁、4岁、10岁、25岁、47岁、70s。相反,在<9年、10-19年、20-29年分别显示0.5、0.2、0.3。
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引用次数: 0
Emergency Transcatheter Aortic Valve Implantation in A Patient with The Assistance of Intra-Aortic Balloon Pump 主动脉内球囊泵辅助急诊经导管主动脉瓣植入术1例
Pub Date : 2021-08-14 DOI: 10.36502/2021/asjbccr.6247
Yan Xu, Pengkun Zhang, Deng-Feng Fang
Surgical aortic valve replacement (SAVR) is considered the gold-standard treatment for patients with severe aortic valve stenosis (AS), yet 30% are considered inappropriate for SAVR on account of the advanced age and multiple comorbidities. Transcatheter aortic valve implantation (TAVI) provides an option for high-risk patients with severe AS, especially for those accompanied with acute cardiogenic shock and multiple organ dysfunction. Herein, we presented a case of a patient resuscitated successfully with TAVI in combination with intra-aortic balloon pump.
外科主动脉瓣置换术(SAVR)被认为是严重主动脉瓣狭窄(AS)患者的金标准治疗方法,但由于高龄和多种合并症,30%的患者被认为不适合进行SAVR。经导管主动脉瓣植入术(TAVI)为严重AS的高危患者提供了一种选择,尤其是那些伴有急性心源性休克和多器官功能障碍的患者。在此,我们介绍了一例患者成功地用TAVI联合主动脉内球囊泵复苏。
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引用次数: 0
Satisfactory Rapid Response to Xultophy Associated with Meal Tolerance Test (MTT) by Carbohydrate Loading 碳水化合物负荷与MTT法联用对徐尔托菌的满意快速反应
Pub Date : 2021-08-12 DOI: 10.36502/2021/asjbccr.6245
H. Bando
The case is a 69-year-old male patient with Type 2 Diabetes Mellitus (T2DM) for 21 years. His diabetic control was not so satisfactory, and his HbA1c value increased in spring 2021. Then, he started Xultophy (IDegLira), which includes a fixed ratio of two agents of basal degludec and liraglutide. Just after providing Xultophy, the daily profile of blood glucose decreased from 179-400 mg/dL to 112-171 mg/dL, with remarkable clinical efficacy. He usually takes 80g of carbohydrates in breakfast, and the meal tolerance test (MTT) was challenged. As carbohydrate loading was given 100-75-50-0%, postprandial hyperglycemia at 60-min showed 277-219-159-133 mg/dL, respectively.
该病例是一名69岁的男性患者,患有2型糖尿病(T2DM)21年。他的糖尿病控制并不令人满意,2021年春季他的HbA1c值增加。然后,他开始了Xultophy(IDegLira),其中包括固定比例的两种药物,即基础药物和利拉鲁肽。在提供Xultophy后,每日血糖从179-400 mg/dL降至112-171 mg/dL,具有显著的临床疗效。他通常在早餐中摄入80克碳水化合物,并对膳食耐受性测试(MTT)提出质疑。当碳水化合物负荷为100-75-50-0%时,60分钟的餐后高血糖分别显示277-219-159-133 mg/dL。
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引用次数: 1
ABO Blood Group System and Periodontal Disease Indices: A Cross-Sectional Study in Greek Adults 希腊成年人ABO血型系统和牙周疾病指数的横断面研究
Pub Date : 2021-08-08 DOI: 10.36502/2021/asjbccr.6244
N. Chrysanthakopoulos
Introduction: Periodontal disease (PD) development has been associated with the presence of causative microorganisms, host immunity and risk factors, whereas the types of periodontal diseases are characterized by interactions between host and bacteria. Moreover, ABO blood groups are the most investigated erythrocyte antigen system. However, a small number of researches have been focused on the possible associations between ABO blood groups and periodontal diseases.Methods: A cross-sectional, epidemiological study was carried out on 854 individuals, 404 males and 450 females, aged 45 to 77. The study sample was interviewed and underwent an oral and dental clinical examination. The assessment of the possible associations between several indices of PD, such as Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) as dependent variables and ABO blood groups A, B, AB, and O as independent ones was carried out by using a multiple regression analysis model.Results: Individuals with blood group A [OR= 2.94, 95% CI = 1.27-3.96] and B [OR= 2.66, 95% CI = 1.11-3.87] were significantly associated with the risk of developing deeper periodontal pockets (PPD) and worse values of attachment loss (CAL) [OR= 2.42, 95% CI= 1.37-3.85] and [OR= 2.31,95% CI=1.25-3.68], respectively. However, no significant associations were recorded between ABO blood groups and BOP [OR= 1.04, 95% CI= 0.92-1.18].Conclusion: A significant association was revealed between A and B blood groups and deeper periodontal pockets and worse attachment loss, whereas no associations were observed between ABO blood groups and bleeding of probing.
牙周病(PD)的发展与病原微生物、宿主免疫和危险因素的存在有关,而牙周病的类型以宿主和细菌之间的相互作用为特征。此外,ABO血型是研究最多的红细胞抗原系统。然而,很少有研究关注ABO血型与牙周病之间可能存在的关联。方法:采用横断面流行病学调查方法,对年龄45 ~ 77岁的854人进行调查,其中男性404人,女性450人。对研究样本进行了访谈并进行了口腔和牙科临床检查。采用多元回归分析模型,评估探查袋深度(PPD)、临床附着损失(CAL)、探查出血(BOP)等指标作为因变量和ABO血型A、B、AB、O作为独立变量之间可能存在的相关性。结果:A型血[OR= 2.94, 95% CI= 1.27-3.96]和B型血[OR= 2.66, 95% CI= 1.11-3.87]与更深的牙周袋(PPD)和更差的附着丧失(CAL)值(OR= 2.42, 95% CI= 1.37-3.85]和[OR= 2.31,95% CI=1.25-3.68]的风险显著相关。然而,ABO血型与BOP之间无显著关联[OR= 1.04, 95% CI= 0.92-1.18]。结论:A、B血型与牙周袋深度加深、附着丧失严重相关,而ABO血型与探诊出血无相关性。
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引用次数: 0
The COVID-19 Vaccines Can Lead to False Positive Mammograms and Breast MRI. How Can we Decrease the Impact Caused by Post-Vaccination Lymphadenopathy in Breast Cancer and Oncology Patients? 新冠肺炎疫苗可能导致乳房X光检查和乳房MRI假阳性。我们如何减少癌症和肿瘤患者接种后淋巴结病的影响?
Pub Date : 2021-07-12 DOI: 10.36502/2021/ASJBCCR.6243
Rasha A. Al-Khafaji
There has been an increase in reporting clinical or radiological axillary lymphadenopathy after the coronavirus disease (COVID-19) vaccination. Cancer care is complex and multidisciplinary, which requires care events to be orchestrated promptly; radiology often serves a key role in diagnosis, post-diagnosis and is sometimes the patient’s first step in cancer care initiation, especially in breast cancer. Radiologists are also a key role in other Multidisciplinary Teams (MDT) dealing with different departments. Therefore, identifying unnecessary management within the health system can generally enhance the patient’s experience, reduce the pressure from providing extra health services, and reduce health costs.Based on personal observation and previous literature, the author concludes that patients having breast cancer or recent breast cancer diagnosis in the pre- or peri-treatment setting could benefit from receiving a vaccination, if possible, in the anterolateral thigh or contralateral arm regardless if this vaccine is for influenza, HPV, etc. Whether this is applicable for the COVID-19 vaccine remains unanswered. This approach will potentially reduce the patient anxiety from having a recurrence or failure of treatment and decrease the strain of the health care system both functionally and economically. In addition, this approach can potentially reduce or eliminate cancellations, delays, and rescheduling of relevant imaging modalities. Also, the author suggests adding a history of vaccinations to all the imaging request forms; countries with digital health services can reap the benefit of generating extensive epidemiological data of post-vaccination lymphadenopathy. Thus, creating new base-evidence guidelines for managing reactive post-vaccination lymphadenopathy, and potentially avoiding duplicating unnecessary imaging and patient over-treatment.
在冠状病毒病(COVID-19)疫苗接种后,报告的临床或放射学腋窝淋巴结病有所增加。癌症治疗是复杂和多学科的,这需要及时安排治疗活动;放射学通常在诊断和诊断后发挥关键作用,有时是患者癌症治疗开始的第一步,特别是乳腺癌。放射科医生也是其他多学科团队(MDT)处理不同部门的关键角色。因此,确定卫生系统内不必要的管理通常可以改善患者的体验,减少提供额外卫生服务的压力,并降低卫生成本。根据个人观察和以前的文献,作者得出结论,在治疗前或治疗期间患有乳腺癌或最近诊断为乳腺癌的患者可能受益于接种疫苗,如果可能的话,在大腿前外侧或对侧手臂接种疫苗,无论该疫苗是针对流感,HPV等。这是否适用于COVID-19疫苗仍然没有答案。这种方法将潜在地减少患者对复发或治疗失败的焦虑,并从功能和经济上减少医疗保健系统的压力。此外,这种方法可以潜在地减少或消除相关成像模式的取消、延迟和重新安排。此外,作者建议在所有成像申请表中添加疫苗接种史;拥有数字卫生服务的国家可以从生成疫苗接种后淋巴结病的广泛流行病学数据中获益。因此,为管理疫苗接种后反应性淋巴结病创建新的基础证据指南,并潜在地避免重复不必要的成像和患者过度治疗。
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引用次数: 0
Palliative Modified Radical Mastectomy to Improve Quality of Life by Decreasing Disease Burden: A Case Report 姑息性改良乳房切除术减轻疾病负担提高生活质量一例报告
Pub Date : 2021-07-02 DOI: 10.36502/2021/ASJBCCR.6242
Sohayla Rostami, S. Ladd, L. Stewart, J. Battista
In cases of advanced pathology, palliative medicine is able to confer a great deal of relief to the patient. In the same light, surgical intervention is able to provide increased quality of life in cases of extensive disease burden, providing palliation where curative measures cannot be achieved. In the case study therein, a patient presents with metastatic breast cancer with a localized fungating mass contributing to severe local and systemic symptomatology. In this setting, invasive management of her disease allowed for clinical improvement of the patient when medical management alone was not sufficient. The patient quickly demonstrated recovery of her symptoms in the post-operative phase when the local disease was resected. The utilization of invasive measures, as seen in this case, further proves the importance of multidisciplinary palliative care where surgical measures are included in patient care.
在晚期病理的情况下,姑息医学能够给患者带来很大的缓解。同样,在疾病负担严重的情况下,手术干预能够提高生活质量,在无法采取治疗措施的情况下提供缓解。在其中的病例研究中,患者表现为转移性癌症,局部真菌肿块导致严重的局部和全身症状。在这种情况下,当单独的医疗管理不够时,对她的疾病进行侵入性管理可以改善患者的临床状况。当局部疾病被切除时,患者在术后阶段很快表现出症状恢复。如本例所示,侵入性措施的使用进一步证明了多学科姑息治疗的重要性,其中手术措施包括在患者护理中。
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引用次数: 0
Renal Infarction and Decreased Splenic Perfusion Secondary to a Left Ventricular Thrombus: A Case Report 左心室血栓继发肾梗死和脾灌注减少1例报告
Pub Date : 2021-07-02 DOI: 10.36502/2021/ASJBCCR.6241
Sahibjot S Bhatia, S. Chamoun, Ashwin Sidhu, M. Zafar, Nalin E. Ranasinghe, L. Ranasinghe
We report a case of a 67-year-old man who presented to urgent care with a one-week history of left-sided abdominal pain and oliguria. Over the past month, he reported feeling fatigued as well as noticed decreased urine output. The patient does have a significant cardiac medical history that includes coronary artery disease with a previous myocardial infarction, reduced ejection fraction, and hypertension. Imaging studies were conducted which revealed the likely etiology of his current symptoms. A transthoracic echocardiogram (TTE) revealed the presence of a large non-mobile apical thrombus occupying most of the apex of the left ventricle. Computed Tomography (CT) confirmed an apical left ventricular thrombus and showed decreased perfusion to the spleen and ischemia/infarction of the left kidney. The patient was initially treated with heparin but subsequently given enoxaparin with bridging to warfarin. He began to feel better with less left flank pain. Although this presentation of an LV thrombus is a rare occurrence, it is important for physicians to consider abdominal pain as a presenting complaint.
我们报告一例67岁的男子谁提出了紧急护理与一个星期的历史,左侧腹痛和少尿。在过去的一个月里,他报告说他感到疲劳,并且注意到排尿量减少。患者有明显的心脏病史,包括冠状动脉疾病伴既往心肌梗死、射血分数降低和高血压。影像学检查揭示了他目前症状的可能病因。经胸超声心动图(TTE)显示存在一个大的不可移动的顶端血栓占据大部分的左心室顶端。计算机断层扫描(CT)证实了一个顶端左心室血栓,显示脾脏灌注减少和左肾缺血/梗死。患者最初接受肝素治疗,但随后给予依诺肝素并桥接华法林。他开始感觉好些了,左侧疼痛减轻了。虽然这种左室血栓的表现是罕见的,但医生认为腹痛是主诉是很重要的。
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引用次数: 0
Some Measures for COVID-19 Including Deep Ultraviolet Light-Emitting Diode (DUV-LED), Gc protein-derived Macrophage-Activating Factor (Gcmaf), and 5-Aminolevulinic Acid (5-ALA) 新冠肺炎的一些措施,包括深紫外线发光二极管(DUV-LED)、Gc蛋白衍生的巨噬细胞激活因子(Gcmaf)和5-氨基乙酰丙酸(5-ALA)
Pub Date : 2021-06-30 DOI: 10.36502/2021/asjbccr.6240
H. Bando
Several trials for the COVID-19 pandemic are found. Prof. Shunji Nakamura, Tokushima University was awarded the 2014 Nobel prize in Physics for light-emitting diodes (LEDs). Deep ultraviolet LED (DUV-LED) causes SARS-CoV-2 inactivation as 99.9% by 265 nm. Gc protein-derived macrophage-activating factor (GcMAF)-based immunotherapy has a wider application for serious infection, chronic fatigue syndrome, and cancers. Covid center in Naples submitted a phase II report concerning GcMAF and COVID-19 in Feb 2021. 5-aminolevulinic acid (5-ALA) and its metabolite protoporphyrin IX (PpIX) show anti-inflammatory and antiviral effects for Zika, Dengue, influenza A viruses, and SARS-CoV-2. These results hopefully contribute to the research development for COVID-19.
发现了几种针对COVID-19大流行的试验。德岛大学中村俊二教授因发光二极管(led)获得2014年诺贝尔物理学奖。深紫外LED (DUV-LED)在265 nm范围内使SARS-CoV-2失活率达到99.9%。以Gc蛋白衍生的巨噬细胞活化因子(GcMAF)为基础的免疫治疗在严重感染、慢性疲劳综合征和癌症等方面有着广泛的应用。那不勒斯的Covid -19中心于2021年2月提交了关于GcMAF和Covid -19的第二阶段报告。5-氨基乙酰丙酸(5-ALA)及其代谢物原卟啉IX (PpIX)对寨卡病毒、登革热病毒、甲型流感病毒和SARS-CoV-2具有抗炎和抗病毒作用。这些结果有望为新冠肺炎的研究发展做出贡献。
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引用次数: 4
A Novel Approach for Removal of an Impacted Extraction Balloon Catheter in Common Bile Duct During ERCP- A Case Report 胆总管ERCP中阻生球囊导管拔除的新方法- 1例报告
Pub Date : 2021-06-08 DOI: 10.36502/2021/ASJBCCR.6238
N. Idrees, S. Hebbar, Rakesh Sringeri
We describe the case of a 75-year-old female who underwent ERCP for choledocholithiasis. The extraction balloon catheter got impacted at the distal end of a common bile duct (CBD) during attempted stone extraction. Multiple attempts by 2 different ERCP experts to remove the balloon catheter proved unsuccessful. At the time the procedure was carried out, Spyglass Cholangioscopy was not available in the hospital. The balloon catheter was cut outside the channel of scope and used as a nasobiliary drain after an oro-nasal conversion. On repeat ERCP, a few days later, the extraction balloon catheter had fallen out spontaneously into the duodenum. The common bile duct was re-cannulated and stone was successfully removed. This is only the second case report of an impacted extraction balloon catheter in CBD.
我们描述一例75岁女性因胆总管结石接受ERCP检查。在尝试取石的过程中,提取球囊导管在胆总管(CBD)的远端受到冲击。两位不同的ERCP专家多次尝试移除球囊导管均未成功。在进行手术时,医院没有Spyglass胆道镜检查。球囊导管在窥镜通道外切开,经口鼻转换后用作鼻胆管引流管。在重复的ERCP检查中,几天后,提取球囊导管自发脱落进入十二指肠。胆总管被重新插管,结石被成功取出。这只是CBD第二例受影响的提取球囊导管病例报告。
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引用次数: 0
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Asploro journal of biomedical and clinical case reports
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