Pub Date : 2022-02-21DOI: 10.36502/2022/asjbccr.6259
M. Okada, H. Bando, Noboru Iwatsuki, T. Ogawa, K. Sakamoto
Background: As an oral hypoglycaemic agent (OHA), imeglimin (Twymeeg) has been recently introduced to clinical practice for patients with type 2 diabetes mellitus (T2DM) as Twymeeg. It has beneficial pharmacological mechanisms, which are improving insulin secretion, increasing insulin sensitivity, and decreasing insulin resistance. Case Presentation: The case is 84-year-old man with mild cognitive impairment (MCI) for 3 years. He visited late August, 2021 our clinic for general malaise and was pointed out to have post-prandial blood glucose 336 mg/dL and HbA1c 8.6%. He was diagnosed with T2DM. Results: He was started to be given imeglimin 1000mg twice a day, and then HbA1c value was decreased to 7.3% in 4 weeks and 5.7% in 8 weeks. During 9-12 weeks, he felt loss of appetite and reduced food intake. Biochemical examination on 12 weeks showed decreased values of TP, Alb, HbA1c, glucose, free T3, and normal values of TSH, free T4. Doses of imeglimin were 500 mg twice a day for 9-12 weeks and discontinued after 12 weeks. Discussion: Regarding appetite loss, possible causes may include MCI, previous history of gallbladder dyskinesia, adverse effect of imeglimin, and so on. Further development of research will be expected for imeglimin in the future.
{"title":"Clinical Efficacy of Imeglimin (Twymeeg) for Elderly Patient with Type 2 Diabetes Mellitus (T2DM)","authors":"M. Okada, H. Bando, Noboru Iwatsuki, T. Ogawa, K. Sakamoto","doi":"10.36502/2022/asjbccr.6259","DOIUrl":"https://doi.org/10.36502/2022/asjbccr.6259","url":null,"abstract":"Background: As an oral hypoglycaemic agent (OHA), imeglimin (Twymeeg) has been recently introduced to clinical practice for patients with type 2 diabetes mellitus (T2DM) as Twymeeg. It has beneficial pharmacological mechanisms, which are improving insulin secretion, increasing insulin sensitivity, and decreasing insulin resistance.\u0000Case Presentation: The case is 84-year-old man with mild cognitive impairment (MCI) for 3 years. He visited late August, 2021 our clinic for general malaise and was pointed out to have post-prandial blood glucose 336 mg/dL and HbA1c 8.6%. He was diagnosed with T2DM.\u0000Results: He was started to be given imeglimin 1000mg twice a day, and then HbA1c value was decreased to 7.3% in 4 weeks and 5.7% in 8 weeks. During 9-12 weeks, he felt loss of appetite and reduced food intake. Biochemical examination on 12 weeks showed decreased values of TP, Alb, HbA1c, glucose, free T3, and normal values of TSH, free T4. Doses of imeglimin were 500 mg twice a day for 9-12 weeks and discontinued after 12 weeks.\u0000Discussion: Regarding appetite loss, possible causes may include MCI, previous history of gallbladder dyskinesia, adverse effect of imeglimin, and so on. Further development of research will be expected for imeglimin in the future.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44807037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-15DOI: 10.36502/2022/asjbccr.6258
Juan Pablo Gualdrón Moncada, Ana María Caballero Mieles, Alexandra Paola Arrieta González, Valeria Olarte Manjarres, Natalia Andrea Cuevas Florez, Laura Vanessa Molina Torres, Diana Lisseth Rodriguez Paredes, Erika Paola Ramirez Escobar, Mayra Alejandra Santander Maury
A febrile seizure is a seizure that occurs in children with a temperature of 38 ºC or more, common in pediatric patients between the ages of 6 to 60 months without intracranial infections, metabolic disorder, or a history of seizures without fever. In 50% of children the first febrile seizure occurs at 2 years and in 90% before 3 years, anemia is also a frequent pathology in pediatric patients, in fact, the figures of the World Health Organization (WHO), point out that iron deficiency anemia attacks children under five years of age, occurring worldwide around 799 million, an average, in the last 10 years, of 42%. And in Latin America, the figure is 23%. Iron deficiency anemia can predispose to the development of febrile seizures because iron plays a crucial role in the transport of oxygen to all tissues, its deficiency also produces a dysfunction of myelination, tyrosine, and tryptophan synthesis hydroxylase, which are necessary for the release of neurotransmitters, therefore, if said neurotransmitters are not released, the brain synapse can be altered and lead to a seizure. Therefore, it is important and relevant to recognize these concepts and the intimate relationship between them, in addition to the risk factors that can trigger them, in order to promote the reduction of the risk of presenting these diseases in vulnerable groups such as pediatric patients.
{"title":"Development of Febrile Seizures in Children with Iron Deficiency Anemia","authors":"Juan Pablo Gualdrón Moncada, Ana María Caballero Mieles, Alexandra Paola Arrieta González, Valeria Olarte Manjarres, Natalia Andrea Cuevas Florez, Laura Vanessa Molina Torres, Diana Lisseth Rodriguez Paredes, Erika Paola Ramirez Escobar, Mayra Alejandra Santander Maury","doi":"10.36502/2022/asjbccr.6258","DOIUrl":"https://doi.org/10.36502/2022/asjbccr.6258","url":null,"abstract":"A febrile seizure is a seizure that occurs in children with a temperature of 38 ºC or more, common in pediatric patients between the ages of 6 to 60 months without intracranial infections, metabolic disorder, or a history of seizures without fever. In 50% of children the first febrile seizure occurs at 2 years and in 90% before 3 years, anemia is also a frequent pathology in pediatric patients, in fact, the figures of the World Health Organization (WHO), point out that iron deficiency anemia attacks children under five years of age, occurring worldwide around 799 million, an average, in the last 10 years, of 42%. And in Latin America, the figure is 23%. Iron deficiency anemia can predispose to the development of febrile seizures because iron plays a crucial role in the transport of oxygen to all tissues, its deficiency also produces a dysfunction of myelination, tyrosine, and tryptophan synthesis hydroxylase, which are necessary for the release of neurotransmitters, therefore, if said neurotransmitters are not released, the brain synapse can be altered and lead to a seizure. Therefore, it is important and relevant to recognize these concepts and the intimate relationship between them, in addition to the risk factors that can trigger them, in order to promote the reduction of the risk of presenting these diseases in vulnerable groups such as pediatric patients.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47924204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-22DOI: 10.36502/2022/asjbccr.6257
Jacquelyn A Combs, Teja Narra, Conway Ou, Deyna Monta Velaz, Justin Chatten-Brown, L. Ranasinghe
Cerebral Vein Thrombosis associated with preeclampsia is a rare phenomenon that is not fully understood and presents a potentially challenging situation for treatment and future management. This case presents a 25-year old female with a history of gestational diabetes and hypertriglyceridemia presenting three days post-partum for an eclamptic seizure complicated by cerebral vein thrombosis and HELLP syndrome. The patient’s presenting symptoms were alleviated by eclampsia procedure, anti-anxiety medication, and two different types of anticoagulation. Thrombectomy was not indicated, as imaging did not suggest any large vein clotting. Future check-ins, as well as careful considerations in the event of future pregnancies, should be pursued by the physicians. Testing and gaining a better understanding of the pathophysiology behind cerebral vein thrombosis proves to be difficult as the occurrence is rare, but looking to previous literature to further an understanding of eclampsia and how it progresses in the body may help to provide a greater insight into similar cases and the approach that should be used in said cases.
{"title":"Post-partum Eclampsia Complicated by Cerebral Venous Thrombosis: Case Report","authors":"Jacquelyn A Combs, Teja Narra, Conway Ou, Deyna Monta Velaz, Justin Chatten-Brown, L. Ranasinghe","doi":"10.36502/2022/asjbccr.6257","DOIUrl":"https://doi.org/10.36502/2022/asjbccr.6257","url":null,"abstract":"Cerebral Vein Thrombosis associated with preeclampsia is a rare phenomenon that is not fully understood and presents a potentially challenging situation for treatment and future management. This case presents a 25-year old female with a history of gestational diabetes and hypertriglyceridemia presenting three days post-partum for an eclamptic seizure complicated by cerebral vein thrombosis and HELLP syndrome. The patient’s presenting symptoms were alleviated by eclampsia procedure, anti-anxiety medication, and two different types of anticoagulation. Thrombectomy was not indicated, as imaging did not suggest any large vein clotting. Future check-ins, as well as careful considerations in the event of future pregnancies, should be pursued by the physicians. Testing and gaining a better understanding of the pathophysiology behind cerebral vein thrombosis proves to be difficult as the occurrence is rare, but looking to previous literature to further an understanding of eclampsia and how it progresses in the body may help to provide a greater insight into similar cases and the approach that should be used in said cases.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45848763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-15DOI: 10.36502/2022/asjbccr.6256
Federico Rovegno, C. Yepes, Jonathan Finkelstein, A. Rovegno
An increased risk of testicular cancer in men with infertility and poor semen quality has been reported. We aim to present a patient who was being studied for infertility and incidentally found a testicular nodule, discuss management and prevalence of small testicular masses.
{"title":"Germ Cell Neoplasia in Situ of the Testis and Azoospermia: Case Report and Review of the Literature","authors":"Federico Rovegno, C. Yepes, Jonathan Finkelstein, A. Rovegno","doi":"10.36502/2022/asjbccr.6256","DOIUrl":"https://doi.org/10.36502/2022/asjbccr.6256","url":null,"abstract":"An increased risk of testicular cancer in men with infertility and poor semen quality has been reported. We aim to present a patient who was being studied for infertility and incidentally found a testicular nodule, discuss management and prevalence of small testicular masses.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45954760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-15DOI: 10.36502/2022/asjbccr.6255
Jian Wu, E.Y.-L. Chu, Cristiana Costa Chase, T. Choi, C. Gasparetto, K. Young, Yubin Kang
Background: Anaplastic multiple myeloma (AMM) is a very rare but distinct subtype of multiple myeloma (MM) with an extremely poor prognosis. Due to its rarity, AMM lacks detailed descriptions and clear definitions. Moreover, there is no consensus on the treatment and evidence suggests that AMM responds poorly to several novel therapies. We conducted a literature review and retrospective case series to determine clinical characteristics, pathological features, and outcomes of AMM. Case Presentation: Published case reports and case series of AMM since 1983 were systematically extracted and reviewed. A total of 52 patients with AMM were reported in the PUBMED since 1983, including 26 males (50%) and 26 females (50%). The age ranged from 29 years old to 85 years old, with a mean age of 57.02 years old. Most of the patients presented with bone pain (23, 44.2%), fatigue (18, 34.6%), plasmacytoma (18, 34.6%) and weight loss (7, 13.5%). The median survival of the patients was 4 months. To investigate the outcomes of patients with AMM in the current era of treatment, a series of 14 patients with AMM diagnosed at our institute between December 2012 and July 2021was retrospectively analyzed. Our retrospective case series consisted of 12 males (85.7%) and 2 females (14.3%), with a mean age of 59 years old. Most of our AMM patients displayed bone lytic lesions as a common manifestation. The common cytogenetic abnormality was 1q amplification. All patients received standard combination chemotherapy consisting of proteasome inhibitors and/or immunomodulatory agents, and half of the patients underwent autologous hematopoietic stem cell transplantation. The median progression-free survival (PFS) and overall survival (OS) for our 14 AMM patients were 0.84 years and 1.52 years, respectively, which was significantly worse than the regular MM patients treated at our institute from 2003–2013 who had a PFS of 2.28 years and OS of 4.92 years. Conclusions: AMM is a very rare, morphologically distinct variant of MM. It has adverse cytogenetics and an aggressive course. It is often resistant to standard chemotherapy and presents with an extremely low survival rate.
{"title":"Anaplastic Multiple Myeloma: Case Series and Literature Review","authors":"Jian Wu, E.Y.-L. Chu, Cristiana Costa Chase, T. Choi, C. Gasparetto, K. Young, Yubin Kang","doi":"10.36502/2022/asjbccr.6255","DOIUrl":"https://doi.org/10.36502/2022/asjbccr.6255","url":null,"abstract":"Background: Anaplastic multiple myeloma (AMM) is a very rare but distinct subtype of multiple myeloma (MM) with an extremely poor prognosis. Due to its rarity, AMM lacks detailed descriptions and clear definitions. Moreover, there is no consensus on the treatment and evidence suggests that AMM responds poorly to several novel therapies. We conducted a literature review and retrospective case series to determine clinical characteristics, pathological features, and outcomes of AMM. Case Presentation: Published case reports and case series of AMM since 1983 were systematically extracted and reviewed. A total of 52 patients with AMM were reported in the PUBMED since 1983, including 26 males (50%) and 26 females (50%). The age ranged from 29 years old to 85 years old, with a mean age of 57.02 years old. Most of the patients presented with bone pain (23, 44.2%), fatigue (18, 34.6%), plasmacytoma (18, 34.6%) and weight loss (7, 13.5%). The median survival of the patients was 4 months. To investigate the outcomes of patients with AMM in the current era of treatment, a series of 14 patients with AMM diagnosed at our institute between December 2012 and July 2021was retrospectively analyzed. Our retrospective case series consisted of 12 males (85.7%) and 2 females (14.3%), with a mean age of 59 years old. Most of our AMM patients displayed bone lytic lesions as a common manifestation. The common cytogenetic abnormality was 1q amplification. All patients received standard combination chemotherapy consisting of proteasome inhibitors and/or immunomodulatory agents, and half of the patients underwent autologous hematopoietic stem cell transplantation. The median progression-free survival (PFS) and overall survival (OS) for our 14 AMM patients were 0.84 years and 1.52 years, respectively, which was significantly worse than the regular MM patients treated at our institute from 2003–2013 who had a PFS of 2.28 years and OS of 4.92 years. Conclusions: AMM is a very rare, morphologically distinct variant of MM. It has adverse cytogenetics and an aggressive course. It is often resistant to standard chemotherapy and presents with an extremely low survival rate.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":"5 1","pages":"1 - 11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41986384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.36502/2021/asjbccr.6254
Kei Tanaka, Shinji Nagahiro, H. Bando
The authors and collaborators have continued practice of hospital art in the university and community hospitals and various research with experts. The material for hospital art is masking tape which is easily made and attached for everyone. Formerly, we have conducted artwork in front of the wall, which took a long time. Currently, we have tried to take the most advantage of the thin-film sheet. Our staff can prepare artwork with a size of 20 cm square in advance. Many square parts with double-sided attachment tape can be gathered together, which is completed and useful in a short time.
{"title":"Further Hospital Art Development of Masking Tape Using Thin Film Sheet","authors":"Kei Tanaka, Shinji Nagahiro, H. Bando","doi":"10.36502/2021/asjbccr.6254","DOIUrl":"https://doi.org/10.36502/2021/asjbccr.6254","url":null,"abstract":"The authors and collaborators have continued practice of hospital art in the university and community hospitals and various research with experts. The material for hospital art is masking tape which is easily made and attached for everyone. Formerly, we have conducted artwork in front of the wall, which took a long time. Currently, we have tried to take the most advantage of the thin-film sheet. Our staff can prepare artwork with a size of 20 cm square in advance. Many square parts with double-sided attachment tape can be gathered together, which is completed and useful in a short time.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49204479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-16DOI: 10.36502/2021/asjbccr.6253
H. Bando
The impact of COVID-19 can be shown by life expectancy, excess death and total years of life lost (YLL). United States showed life expectancy minus 1.67 years, excess deaths 375,235 and total YLL 7,362,555. The excess death of Japan has remained minus value for long, in which long-term care facilities (LTCF) may contribute. LTCF has characteristic points as i) mutual interrelationships between hospitals, medical societies and prefectural offices, ii) rapid communication channels for regulatory official authorities, iii) high degree of citizenship and cooperation of all Japanese people for daily life and iv) mild lockdown without any punishment with declaration.
{"title":"Several Effective Measures for Minus Excess Mortality of COVID-19 in Japan Including Mutual Interrelationships and Long-Term Care Facilities (LTCF)","authors":"H. Bando","doi":"10.36502/2021/asjbccr.6253","DOIUrl":"https://doi.org/10.36502/2021/asjbccr.6253","url":null,"abstract":"The impact of COVID-19 can be shown by life expectancy, excess death and total years of life lost (YLL). United States showed life expectancy minus 1.67 years, excess deaths 375,235 and total YLL 7,362,555. The excess death of Japan has remained minus value for long, in which long-term care facilities (LTCF) may contribute. LTCF has characteristic points as i) mutual interrelationships between hospitals, medical societies and prefectural offices, ii) rapid communication channels for regulatory official authorities, iii) high degree of citizenship and cooperation of all Japanese people for daily life and iv) mild lockdown without any punishment with declaration.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42289514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-02DOI: 10.36502/2021/asjbccr.6252
Tanvi Chokshi, Alexandra Theodosopoulos, E. Wilson, Michael Ysit, Sameir Alhadi, L. Ranasinghe
Delayed hemothorax is a potentially life-threatening complication of thoracic trauma that should be carefully considered in all patients presenting with thoracic injury. We report a case of delayed hemothorax in a 77-year-old male presenting eleven days’ status post multiple right mid- to high-rib fractures. His case was complicated by retained hemothorax after CT-guided chest-tube with subsequent video-assisted tube thoracostomy (VATS) revealing fibrothorax necessitating conversion to open thoracotomy. Known risk factors for development of delayed hemothorax include older patient age, three or more rib fractures, and presence of mid- to high-rib fractures, and should be used in risk stratification of thoracic trauma. Tube thoracostomy is often sufficient in management of delayed hemothorax. In rare cases, hemothoraces can be complicated by retained hemothorax or fibrothorax, which require more invasive therapy and carry greater morbidity and mortality.
{"title":"A Case Report of Delayed Hemothorax Complicated by Fibrothorax","authors":"Tanvi Chokshi, Alexandra Theodosopoulos, E. Wilson, Michael Ysit, Sameir Alhadi, L. Ranasinghe","doi":"10.36502/2021/asjbccr.6252","DOIUrl":"https://doi.org/10.36502/2021/asjbccr.6252","url":null,"abstract":"Delayed hemothorax is a potentially life-threatening complication of thoracic trauma that should be carefully considered in all patients presenting with thoracic injury. We report a case of delayed hemothorax in a 77-year-old male presenting eleven days’ status post multiple right mid- to high-rib fractures. His case was complicated by retained hemothorax after CT-guided chest-tube with subsequent video-assisted tube thoracostomy (VATS) revealing fibrothorax necessitating conversion to open thoracotomy. Known risk factors for development of delayed hemothorax include older patient age, three or more rib fractures, and presence of mid- to high-rib fractures, and should be used in risk stratification of thoracic trauma. Tube thoracostomy is often sufficient in management of delayed hemothorax. In rare cases, hemothoraces can be complicated by retained hemothorax or fibrothorax, which require more invasive therapy and carry greater morbidity and mortality.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45027676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pilomatrical Carcinoma (PC) is a rare malignant adnexal tumor with matrical differentiation. Its benign counterpart (Pilomatrixoma) is diagnosed much more frequently in daily pathological practice. Both entities share genetic alterations but the malignant counterpart acquires mutations that make it develop an aggressive behavior [1]. We describe a 33-year-old man who presented with a 7 x 6 cm nodular ulcerated lesion in the left ear with markedly accelerated growth in the last month. Incisional biopsy was referred to us with suspicion of squamous cell carcinoma versus pyogenic granuloma. Histologic sections showed ulcerated fragments infiltrated by a basaloid cell proliferation interspersed with groups of “ghost cells”. The neoplastic cells were arranged in irregular sheets with infiltrative borders. Groups of Squamous cells with trichilemmal keratinization and foci of necrosis were also identified. The biopsy was diagnosed as an adnexal neoplasm with pilomatrical differentiation, suggesting its complete resection with safety margins due to the presence of aggressive characteristics. The subsequent study of the excisional biopsy showed similar characteristics to those previously described. Notoriously, focal infiltration of the auricular cartilage was identified, leading us to the undoubted diagnosis of pilomatrical carcinoma.
毛瘤样癌（PC）是一种罕见的伴有基质分化的附件恶性肿瘤。它的良性对应物（毛瘤）在日常病理实践中被诊断得更频繁。这两种实体都有共同的基因改变，但恶性对应物获得突变，使其发展为攻击性行为[1]。我们描述了一名33岁的男子，他在左耳出现7 x 6厘米的结节性溃疡病变，上个月生长明显加快。我们怀疑是鳞状细胞癌还是化脓性肉芽肿。组织学切片显示溃疡碎片被基底样细胞增殖浸润，其间穿插着一组“幽灵细胞”。肿瘤细胞呈不规则片状排列，边界呈浸润性。还发现了具有毛膜角化和坏死灶的鳞状细胞群。活检被诊断为具有毛基质分化的附件肿瘤，这表明由于存在侵袭性特征，其完全切除具有安全边际。随后对切除活检的研究显示出与先前描述的相似的特征。臭名昭著的是，发现了耳廓软骨的局灶性浸润，这使我们对毛基质癌的诊断毫无疑问。
{"title":"Case Report and Highlight Clues on the Diagnosis of Pilomatrical Carcinoma","authors":"Lewkowicz Milagros, Greco Alejandro, Lezcano Gabriel, Cachau Victoria, Díaz Florencia","doi":"10.36502/2021/asjbccr.6251","DOIUrl":"https://doi.org/10.36502/2021/asjbccr.6251","url":null,"abstract":"Pilomatrical Carcinoma (PC) is a rare malignant adnexal tumor with matrical differentiation. Its benign counterpart (Pilomatrixoma) is diagnosed much more frequently in daily pathological practice. Both entities share genetic alterations but the malignant counterpart acquires mutations that make it develop an aggressive behavior [1].\u0000\u0000We describe a 33-year-old man who presented with a 7 x 6 cm nodular ulcerated lesion in the left ear with markedly accelerated growth in the last month. Incisional biopsy was referred to us with suspicion of squamous cell carcinoma versus pyogenic granuloma.\u0000\u0000Histologic sections showed ulcerated fragments infiltrated by a basaloid cell proliferation interspersed with groups of “ghost cells”. The neoplastic cells were arranged in irregular sheets with infiltrative borders. Groups of Squamous cells with trichilemmal keratinization and foci of necrosis were also identified. The biopsy was diagnosed as an adnexal neoplasm with pilomatrical differentiation, suggesting its complete resection with safety margins due to the presence of aggressive characteristics. The subsequent study of the excisional biopsy showed similar characteristics to those previously described. Notoriously, focal infiltration of the auricular cartilage was identified, leading us to the undoubted diagnosis of pilomatrical carcinoma.","PeriodicalId":93523,"journal":{"name":"Asploro journal of biomedical and clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45811891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-28DOI: 10.36502/2021/asjbccr.6249
T. Yokoyama, H. Bando
Transactional Analysis (TA) has been a personality theory beneficial to mutual communication associated with the research of egogram. Tokyo University Egogram (TEG) has been a reliable psychological battery. TEG ver3 was recently introduced, which was applied to 98 university students. The results for 5 egogram factors were compared to previous standard values. Similar data were observed in Critical Parent(CP), Nurturing Parent(NP), and Adult(A). Higher tendency values (vs standard value) were found in male Free Child (FC) 12.3 vs 10.6, male Adapted Child (AC) 13.6 vs 10.0, and female AC 14.8 vs 10.8. Further study for TEG will be expected in the future.
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