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Epistemological Aspects of Simulation Models for Decision Support 决策支持模拟模型的认识论方面
Pub Date : 2013-04-01 DOI: 10.4018/jats.2013040103
A. Dekker
In this paper, the author explores epistemological aspects of simulation with a particular focus on using simulations to provide recommendations to managers and other decision-makers. The author presents formal definitions of knowledge (as justified true belief) and of simulation. The author shows that a simple model, the Kuramoto model of coupled-oscillators, satisfies the simulation definition (and therefore generates knowledge) through a justified mapping from the real world. The author argues that, for more complex models, such a justified mapping requires three techniques: using an appropriate and justified theoretical construct; using appropriate and justified values for model parameters; and testing or other verification processes to ensure that the mapping is correctly defined. The author illustrates these three techniques with experiments and models from the literature, including the Long House Valley model of Axtell et al., the SAFTE model of sleep, and the Segregation model of Wilensky. Epistemological Aspects of Simulation Models for Decision Support
在本文中,作者探讨了模拟的认识论方面,特别侧重于使用模拟为管理者和其他决策者提供建议。作者提出了知识(作为被证实的真信念)和模拟的正式定义。作者证明了一个简单的模型,即耦合振荡器的Kuramoto模型,通过从现实世界的合理映射来满足仿真定义(从而产生知识)。作者认为,对于更复杂的模型,这种合理的映射需要三种技术:使用适当和合理的理论结构;使用适当和合理的模型参数值;以及测试或其他验证过程,以确保映射被正确定义。作者用文献中的实验和模型来说明这三种技术,包括Axtell等人的长屋谷模型、睡眠的SAFTE模型和Wilensky的隔离模型。决策支持模拟模型的认识论方面
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引用次数: 5
Hierarchical Multi-Agent Plans Using Model-Based Petri Net 基于模型Petri网的分层多智能体规划
Pub Date : 2013-04-01 DOI: 10.4018/jats.2013040101
Said Brahimi, R. Maamri, Z. Sahnoun
Agents evolving in complex and dynamic multi-agent systems need to plan their tasks and to adapt their behavior in order to react to unpredictable events. Therefore they must have plans that remain subject to continual updating, even during its execution. Although this property is important in dynamic environments, it is difficult to have a trade-off between the convergence towards the goal to be reached and the reaction to unanticipated events. To cope with this issue, it is needed to have a model allowing to represent plans less sensitive to execution contexts, and to support flexible execution. This paper aims to provide an adequate plan representation, by taking advantage of hierarchical plans and extensions to Petri net. The authors extend the Petri net to take into account the different abstraction levels of plans and the resources required by tasks. To cope with the interdependence of tasks, the authors include in the model, a synchronization mechanism between concurrent transitions. The proposed model can be used to reason on abstract levels of plans and to analyze, in a dynamic way, situations in which the execution of the plan can be performed in any ways, in some ways, or cannot be performed. Hierarchical Multi-Agent Plans Using Model-Based Petri Net
在复杂、动态的多智能体系统中,智能体需要对自己的任务进行规划,调整自己的行为,以便对不可预测的事件做出反应。因此,他们必须有持续更新的计划,即使在执行期间也是如此。尽管这一特性在动态环境中很重要,但很难在趋同目标和对意外事件的反应之间做出权衡。为了解决这个问题,需要有一个模型来表示对执行上下文不那么敏感的计划,并支持灵活的执行。本文的目的是利用分层规划和对Petri网的扩展,提供一个充分的规划表示。作者扩展了Petri网,以考虑到不同的计划抽象级别和任务所需的资源。为了处理任务之间的相互依赖,作者在模型中包含了并发转换之间的同步机制。所建议的模型可用于在计划的抽象层次上进行推理,并以动态的方式分析计划的执行可以以任何方式执行、以某些方式执行或不能执行的情况。基于模型Petri网的分层多智能体规划
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引用次数: 8
On the Epistemological, Ontological, Teleological and Methodological Currents in Modeling and Simulation: An Overview 论建模与仿真中的认识论、本体论、目的论和方法论潮流:综述
Pub Date : 2013-01-01 DOI: 10.4018/jats.2013010101
I. Bozkurt, J. Padilla
Modeling and Simulation (M&S) has been used to solve problems, make decisions, and understand complex phenomena. Scholars have tried to understand and formulate the epistemic value of gained insights through models and simulations. Questions such as how insights are considered knowledge, what the tradeoff between perspectives and objectivity is, what kind of purpose models and simulations fulfill, and how M&S is used within a research methodology paradigm are a starting point of discussing the philosophical underpinnings. The epistemological, ontological, teleological and methodological (E/O/T/M) considerations of M&S is the main motivation of this paper. A comprehensive literature review on E/O/T/M considerations provides an initial roadmap to study the nature of M&S leading to the following questions: How can the authors define canons of research for M&S based on E/O/T/M? How can they define an E/O/T/M-based meta-model to characterize models and simulations? And how can the authors study validation of models and simulations based on E/O/T/M considerations? DOI: 10.4018/jats.2013010101 2 International Journal of Agent Technologies and Systems, 5(1), 1-18, January-March 2013 Copyright © 2013, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. at those commonalities is by looking at E/O/T/M foundations (premises and assumptions) of the use of M&S across disciplines. From a high-level perspective, M&S uses models to represent a phenomenon of interest and simulates these models to gain insight or to predict. Gaining insight or prediction suggests that knowledge is generated from the modeling and/or simulation activity. This knowledgegeneration activity has been under deliberation on questions such as: Can simulations generate knowledge? What kind of knowledge do simulations generate? Does simulation need its own epistemology? Although these are epistemological questions, they are not separate from ontological, methodological, and teleological issues regarding the modeler’s perspective, approach, and intent. Frigg and Reiss (2009), for instance, argue that despite simulation creating parallel worlds on more ideal conditions than the “real world”, this is not unique to simulation; ergo it does not warrant a new philosophy of science. Humphreys (2009), on the other hand, states that with the introduction of computational science new issues also have arisen within the discipline of philosophy of science, namely: epistemic opacity, semantics, temporal dynamics, and practice not principle. Epistemic opacity refers to cognitive agents’ limited access to knowledge; semantics refers to how simulations are applied to real system given the detachment of simulations from reality, how computer simulations are limited by syntax of computer code, and how semantics are subsumed under that syntax; temporal dynamics refers to the temporal representations of dynamic processes involved in simulation
建模与仿真(M&S)已被用于解决问题、做出决策和理解复杂现象。学者们试图通过模型和模拟来理解和制定获得的见解的认知价值。诸如如何将洞察力视为知识,视角和客观性之间的权衡是什么,模型和模拟实现了什么样的目的,以及如何在研究方法范式中使用M&S等问题是讨论哲学基础的起点。在认识论、本体论、目的论和方法论(E/O/T/M)方面的考虑是本文的主要动机。对E/O/T/M考虑因素的全面文献综述为研究M&S的性质提供了一个初步的路线图,导致以下问题:作者如何根据E/O/T/M定义M&S的研究规范?他们如何定义一个基于E/O/T/ m的元模型来描述模型和模拟?作者如何研究基于E/O/T/M考虑的模型验证和仿真?DOI: 10.4018 /贾特人。2013010101 2国际代理技术与系统学报,5(1),1- 18,2013年1月- 3月版权所有©2013,IGI Global。未经IGI Global书面许可,禁止以印刷或电子形式复制或分发。要了解这些共性,就要考察跨学科使用M&S的E/O/T/M基础(前提和假设)。从高层次的角度来看,M&S使用模型来表示感兴趣的现象,并模拟这些模型以获得洞察力或预测。获得洞察力或预测表明知识是从建模和/或模拟活动中产生的。这个知识生成活动一直在讨论以下问题:模拟能产生知识吗?模拟能产生什么样的知识?模拟需要自己的认识论吗?尽管这些都是认识论问题,但它们与建模者的观点、方法和意图相关的本体论、方法论和目的论问题并不是分开的。例如,Frigg和Reiss(2009)认为,尽管模拟在比“真实世界”更理想的条件下创造了平行世界,但这并不是模拟所独有的;因此,它不能保证有一种新的科学哲学。另一方面,Humphreys(2009)指出,随着计算科学的引入,科学哲学学科也出现了新的问题,即:认知不透明、语义、时间动态和实践而非原则。认知不透明是指认知主体对知识的获取有限;语义指的是在模拟脱离现实的情况下,如何将模拟应用于真实系统,计算机模拟如何受到计算机代码语法的限制,以及语义如何包含在该语法下;时间动力学是指涉及模拟的动态过程的时间表征,是科学哲学在预测速度方面的基本要素,而不是演绎;最后,实践,而不是原则,是指计算方法如何迫使研究人员区分哪些是实际适用的,哪些只能作为原则。正如可以推断的那样,模拟和现实之间的差距以及如何以一种可以建立知识的方式弥合它具有认识论,本体论,方法论和目的论的含义。这些影响包括验证(Klein & Herskovitz, 2005)、仿真模型的制定和表征(Lenhard, 2007)等问题,以及最终,仿真是否产生和/或应用知识。为了深入了解这些问题,我们建议研究如何使用E/O/T/M考虑来表征模型和模拟。Turnitsa、Padilla和Tolk(2010)通过将E/O/T考虑与Ogden和Richards(1923)提出的符号学三角思想重叠,对这一命题进行了介绍。本文对其模型进行了修改,如图1所示。下面的讨论还为“对象”、“模型”和“仿真”的定义奠定了基础,这些定义将在整篇论文中使用。M&S的出发点是一个物体/现象,可以是真实的,也可以是想象的。然后,该模型成为该对象的概念化。换句话说,模型应该捕获对对象/参考/问题的理解,并促进其计算机实现。因此,模型可以具有从非正式到正式的多种形式:心智模型、UML图、本体论或数学方程。值得注意的是,该模型不一定是可计算的,但它应该有助于其计算机实现。这一立场与Robinson(2008)和Zeigler, Praehofer, and Kim(2000)的观点一致。 这种将模型作为对象/问题的概念化的立场也可以追溯到系统科学(mitroof et al., 1974)。在这种情况下,该模型没有导致模拟,而是导致可以获得解析解的另一个模型。模拟是模型的计算机实现(它是另一个模型),并允许对一种现象进行长期研究。因此,它必须在本质上是正式的,以便在计算机中执行。应当指出,我们指的是建设性的模拟。有些模拟是需要的,但不是可计算的。在这些情况下,使用实时模拟。假设模型是对象和仿真的表示,本文档的完整版本还有16页,可以使用产品网页上的“添加到购物车”按钮购买:www.igi-global.com/article/epistemological-ontologicalteleological-methodological-currents/77662?camid=4v1此标题可在InfoSci-Journals, InfoSci-Journal journals computers Science, Security, and Information Technology中找到。向您的图书管理员推荐此产品:www.igi-global.com/e-resources/libraryrecommendation/?id=2
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引用次数: 4
Distributed Agency 分布式机构
Pub Date : 2013-01-01 DOI: 10.4018/jats.2013010103
E. Suárez, M. Castañón-Puga
Distributed Agency is the name of a conceptual framework for describing complex adaptive systems that this paper develops. To understand the complexity of the world in a holistic fashion, the field of Modeling and Simulation is currently lacking a common terminology in which different bodies of knowledge can communicate with each other in a general language. In this work, agency is proposed as the common link between the different dimensions of reality, expressing the influence of one dimension on another. This conceptualization is based on a process of backwards induction where nested actors such as an evolved organism or a human choice can be represented as the resulting force of intertwined aims and constraints. The theoretical framework can serve as a point of reference for the social and computational researcher by communicating structural and emergent properties that are essential for the understanding of social and evolutionary phenomena such as companies, economies, governments, and ecosystems. DOI: 10.4018/jats.2013010103 International Journal of Agent Technologies and Systems, 5(1), 32-52, January-March 2013 33 Copyright © 2013, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. (Nonaka & Nishiguchi, 2001). In such a world, the independence of events that is assumed in classical statistics theory no longer holds true and a holistic approach is necessary (Crutchfield, 1994; Biggiero, 2001). In order to appropriately model complex human behavior we must define a canvas in which multiple dimensions of our existence can be defined (Stepney, Polack, & Turner, 2006; Tolk, 2012). Emergent phenomena are ubiquitous in systems that are separated into distinct ontological levels, such as it is in human societies full of consumers, coalitions, families, loyalties, firms, laws, cartels, institutions and governments (Márquez, Castañón-Puga, Castro, & Suarez, 2011). In this sense, our proposal cannot be tied to any one particular model. Instead, the intent is to create a way in which a myriad of non-orthogonal but distinct bodies of knowledge can be expressed in a meta-model of translatable terminology. If we think of a model as a song, then DA could be more accurately compared to a musical staff in which any song can be written than to any particular composition. While the ultimate aim of this work is to foster the discussion for the development of a common interdisciplinary language to describe multiple levels of reality, the immediate aim is to propose a framework that can be used in the computational description of a multidimensional reality. The rapidly expanding world of the computer simulation—a paradigm with foundations generally related to Multi-Agent Systems (MAS)—is based on independent agents that strategically interact with each other (Van der Hoek & Wooldridge, 2008). The independence granted to the agents in MAS is a computational one, in the sense that each agent pro
换句话说,在我们有更正式的方法直接从每个人的神经回路中提取信息之前,我们唯一的数据是在现实世界中观察到的实际偏好,实际的社会结构,实际进化的生物体。描述行为的本体论框架不仅要允许描述世界的任何物理方面,而且还要描述该文档完整版本中另外19个页面的不同方面,这些页面可以使用产品网页上的“添加到购物车”按钮购买:www.igi-global.com/article/distributedagency/77664?camid=4v1本标题可在infosci期刊,infosci期刊学科计算机科学,安全和信息技术。向您的图书管理员推荐此产品:www.igi-global.com/e-resources/libraryrecommendation/?id=2
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引用次数: 58
Simulation of HIV Infection Propagation Networks: A Review of the State of the Art in Agent-Based Approaches HIV感染传播网络的模拟:基于agent方法的最新进展综述
Pub Date : 2013-01-01 DOI: 10.4018/jats.2013010104
Alfredo Tirado-Ramos, Chris Kelley
Simulating the transmission of HIV requires a model framework that can account for the complex nature of HIV transmission. In this paper the authors present the current state of the art for simulating HIV with agent-based models and highlight some of the significant contributions of current research. The authors then propose opportunities for future work including their plan that involves identifying and monitoring high-risk drug users that can potentially initiate high-risk infection propagation networks. DOI: 10.4018/jats.2013010104 54 International Journal of Agent Technologies and Systems, 5(1), 53-63, January-March 2013 Copyright © 2013, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. this paper we explore simulation approaches to the propagation of infection networks, specifically the state of the art in agent-based models, a type of approach that has consistently proved to be a significant tool to simulate the spread of infection disease. Some of the more cited agent-based approaches found in the literature are presented, along with a discussion of future work in the context of our efforts on monitoring the pandemic within high-risk, drug abusing HIV+ populations.
模拟艾滋病毒的传播需要一个能够解释艾滋病毒传播复杂性的模型框架。在本文中,作者介绍了用基于主体的模型模拟HIV的最新技术,并强调了当前研究的一些重要贡献。这组作者随后提出了未来工作的机会,包括他们的计划,包括识别和监测可能引发高风险感染传播网络的高风险吸毒者。DOI: 10.4018 /贾特人。2013010104 54 Agent Technologies and Systems, 5(1), 53-63, jan - march 2013版权所有©2013,IGI Global。未经IGI Global书面许可,禁止以印刷或电子形式复制或分发。本文探讨了感染网络传播的模拟方法,特别是基于智能体的模型中的最新技术,这种方法一直被证明是模拟传染病传播的重要工具。介绍了在文献中发现的一些被引用较多的基于药物的方法,并讨论了我们在监测高风险、滥用药物的艾滋病毒+人群中流行病的努力背景下的未来工作。
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引用次数: 8
The Contribution of Social Simulation in the Advancement of Marketing Issues and Challenges 社会模拟对市场营销问题和挑战的贡献
Pub Date : 2013-01-01 DOI: 10.4018/jats.2013010102
Mario Gonzalez-Fuentes
For some years now, marketers have been praising for a more holistic approach of a company’s marketing efforts across all areas. However, traditional models show serious limitations to address the complexities of managing all of a company’s touch points with a customer. Agent-based modeling (ABM) has opened the door to explore the unfolding behaviors and outputs of an increasingly connected and interactive marketplace. The contribution of this paper is twofold. On the one hand, it provides researchers with a state-of-the-art repository for this strand of research. This facilitates the identification of relevant gaps in the literature and future research avenues. Second, it contributes to assess the way ABM has improved our understanding of the dynamics of markets and its participants when marketing strategies are implemented. Both goals aim at showing the various ways that social simulation has expanded our understanding of marketing and the future research opportunities for both, marketing and computer scientists. DOI: 10.4018/jats.2013010102 20 International Journal of Agent Technologies and Systems, 5(1), 19-31, January-March 2013 Copyright © 2013, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. limitation relates to the constrained number of factors these approaches can incorporate as well as the level of detail they can accommodate. Kiesling et al. (2012) highlight that some of these traditional methodologies are not properly designed to account for the pervasive effect of interaction and community-building on an agent’s behavior. They argue this limitation significantly constraints the utility of traditional approaches to address policy implementation (what-if) questions, which are quite frequent in managerial decisions. Finally, these traditional techniques fail to explicitly incorporate consumers’ heterogeneity and the complexity behind social phenomena (North et al., 2010; Kiesling et al., 2012); two features that are bound to be present in every marketing interaction between two or more agents. It is until recently that marketing scholars started to explore the complexities of marketplaces by applying social simulation approaches. This rising interest is motivated by the possibility, opened by these simulation models, to more effectively monitor and evaluate the outcomes of marketing actions and policies. In particular, agent-based modeling (ABM) is one of the most popular simulation approaches applied by marketing scholars thanks to its ground-up or bottom-up nature. This is because, in ABM, the group-level structures emerge as a result of the simulation, based on a population of heterogeneous agents and the operational rules of their interactions. In other words, the model is defined at the individual or micro-level, and the representation of these features in a simulation result in the emergence of collective or macrolevel phenomena. In more traditional linear a
这需要公司所有职能领域的政策和行动的一致性,这意味着员工之间的协调不仅在个人层面,而且在团队层面。整体营销策略的有效应用在很大程度上依赖于对激励如何在部门间和部门内产生不同结果的理解。多层聚合结构的相互依赖以及个体agent的异质性,需要明确考虑本文档完整版中另外11页带来的非线性效应,可通过产品网页上的“添加到购物车”按钮购买:www.igi-global.com/article/contribution-social-simulationadvancement-marketing/77663?camid=4v1本标题可在InfoSci-Journals, InfoSci-Journal journals computers, Security, and Information Technology, InfoSci-Artificial Intelligence and Smart Computing ejournalcollection, InfoSci-Journal journals Engineering, Natural and Physical Science, InfoSci-Select中找到。向您的图书管理员推荐此产品:www.igi-global.com/e-resources/libraryrecommendation/?id=2
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引用次数: 2
Asynchronous Modeling and Simulation with Orthogonal Agents 正交代理异步建模与仿真
Pub Date : 2012-10-01 DOI: 10.4018/jats.2012100102
R. Tankelevich
This paper considers a class of systems of autonomous self-governed agents with purpose-specific behavior. Agents of this class contribute most to the overall performance if they have an unobstructed transparent access to the environment. Many examples of such systems can be found in swarm technologies and asynchronous simulation of discrete and continuous systems. An efficiency metric for a multi-agent system operating within a given environment is proposed as a dot product of the system's characteristic time-vectors: one of an agent's demands for resources and the other of the resources' availability. It is shown that the smaller the dot product the higher the efficiency of the agents. In some cases, the better efficiency of individual agents translates into improvement of the overall performance of the system. This observation is postulated as the principle of orthogonality: under some conditions, the asynchronous, ungoverned systems outperform the systems with synchronized actions. It is shown that the asynchronous "chaotic" multi-agent models, properly devised to achieve a higher level of transparency, can produce a better throughput beyond the level achieved by simply improving the latency of the system. Examples of orthogonal systems include many discrete-continuous physical, financial, control and some machine learning multi-agent models. Conditions of convergence of asynchronous models are presented. Some experimental results are shown, as well. More general observations are made in the context of natural decomposition.
本文考虑一类具有特定目的行为的自主自治智能体系统。如果该类代理能够畅通无阻地透明访问环境,则它们对整体性能的贡献最大。这种系统的许多例子可以在群体技术和离散和连续系统的异步仿真中找到。提出了在给定环境中运行的多智能体系统的效率度量,作为系统特征时间向量的点积:一个智能体对资源的需求和另一个资源的可用性。结果表明,点积越小,代理效率越高。在某些情况下,单个代理的效率提高转化为系统整体性能的提高。这个观察结果被假定为正交性原则:在某些条件下,异步的、不受控制的系统优于具有同步操作的系统。结果表明,适当设计异步“混沌”多智能体模型以实现更高的透明度,可以产生比简单地提高系统延迟所达到的水平更好的吞吐量。正交系统的例子包括许多离散连续的物理、金融、控制和一些机器学习多智能体模型。给出了异步模型的收敛条件。并给出了一些实验结果。更一般的观察是在自然分解的情况下进行的。
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引用次数: 7
An Agent-Based Model of the Spread of Devil Facial Tumor Disease in an Isolated Population of Tasmanian Devils 魔鬼面部肿瘤疾病在孤立的袋獾种群中传播的基于agent的模型
Pub Date : 2012-10-01 DOI: 10.4018/jats.2012100101
C. Knadler
The Tasmanian devil population is being reduced in the wild at an alarming rate due to an epidemic, which is the result of an unusual disease mechanism. Infected animals "inject" cancer cells into other devils, which then clone the cells, developing tumors. These tumors are invariably fatal. Field observers have developed hypotheses that include a life-history change for the species. It is hypothesized that this change has the potential to improve the population's survivability. An agent-based model of Tasmanian devils is used to evaluate these hypotheses. The model results suggest that the devils' intra-gender aggression as well as their aggressive mating practices render the life-history change hypotheses' correctness improbable.
由于一种不寻常的疾病机制造成的流行病,野生袋獾的数量正在以惊人的速度减少。受感染的动物将癌细胞“注射”到其他魔鬼体内,然后这些魔鬼克隆这些细胞,形成肿瘤。这些肿瘤总是致命的。现场观察人员提出了一些假设,其中包括该物种的生活史发生了变化。据推测,这种变化有可能提高种群的生存能力。一个基于主体的袋獾模型被用来评估这些假设。该模型的结果表明,魔鬼的性别内攻击性以及它们攻击性的交配行为使得生活史变化假说的正确性变得不太可能。
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引用次数: 6
On Modeling and Verification of Agent-Based Traffic Simulation Properties in Alloy 基于agent的合金交通仿真特性建模与验证
Pub Date : 2012-10-01 DOI: 10.4018/jats.2012100103
J. Valente, F. Araujo, Rym Zalila-Wenkstern
The advances in Intelligent Transportation Systems ITS call for a new generation of traffic simulation models that support connectivity and collaboration among simulated vehicles and traffic infrastructure. In this paper we introduce MATISSE, a complex, large scale agent-based framework for the modeling and simulation of ITS and discuss how Alloy, a modeling language based on set theory and first order logic, was used to specify, verify, and analyze MATISSE's traffic models.
智能交通系统(ITS)的发展需要新一代交通模拟模型,以支持模拟车辆和交通基础设施之间的连接和协作。在本文中,我们介绍了MATISSE,一个复杂的,大规模的基于智能体的框架,用于ITS的建模和仿真,并讨论了如何使用Alloy,一种基于集合论和一阶逻辑的建模语言,来指定,验证和分析MATISSE的交通模型。
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引用次数: 4
Falsifying an Enzyme Induction Mechanism within a Validated, Multiscale Liver Model 在一个经过验证的多尺度肝脏模型中伪造酶诱导机制
Pub Date : 2012-07-01 DOI: 10.4018/jats.2012070101
Glen E. P. Ropella, Tempus Dictum, R. Kennedy
The focus is an In Silico Liver ISL model family and an evolving suite of mechanistic hypotheses about rat liver-drug interactions. ISLs are multiscale and hierarchical. A medium grain Enzyme Induction mechanism was implemented. Validation falsification of complicated, knowledge-based models requires integrating distinct aspects and methods for multi-aspect validation. For ISLs, such integration has not been straightforward. Falsification is crucial for formulating, testing, and iteratively evolving hypotheses about liver mechanisms. During multi-aspect falsification, the authors can falsify a hypothesis in one aspect while simultaneously validating it in another aspect. The authors demonstrate a multi-scalar validation/falsification event in which they validate the mechanism against coarse grain measures of liver perfusate drug levels and falsify it against a medium grained measure of hepatic zonation. The authors also discuss how falsification is guiding mechanism hypothesis refinement. The ability to scale validation efforts is necessary for effective scientific use models such as ISLs.
重点是一个硅肝ISL模型家族和关于大鼠肝脏药物相互作用的一套不断发展的机制假设。isl是多尺度和分层的。采用中粒酶诱导机制。复杂的、基于知识的模型的验证证伪需要整合不同的方面和方法来进行多方面的验证。对于isl来说,这种整合并不是直截了当的。证伪是至关重要的制定,测试,并迭代发展假设关于肝脏机制。在多重证伪过程中,作者可以在一个方面证伪假设的同时,在另一个方面证实它。作者展示了一个多标量验证/证伪事件,其中他们验证了针对肝脏灌注药物水平的粗粒度测量的机制,并对肝脏分区的中粒度测量进行了证伪。作者还讨论了证伪是如何指导机制假设的细化。规模验证工作的能力对于有效的科学使用模型(如isl)是必要的。
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引用次数: 9
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International journal of agent technologies and systems
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