Pub Date : 2024-07-10DOI: 10.3389/fsens.2024.1436661
Dermot Diamond
{"title":"Editorial: Thought leaders in sensor research: volume 1","authors":"Dermot Diamond","doi":"10.3389/fsens.2024.1436661","DOIUrl":"https://doi.org/10.3389/fsens.2024.1436661","url":null,"abstract":"","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141659137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-04DOI: 10.3389/fsens.2024.1401077
Ana C. V. Piccinin, Andrey Coatrini-Soares, Giuliana T. Franco, T. J. Bondancia, Juliana Coatrini-Soares, Osvaldo N. Oliveira, L. H. Mattoso
An electronic tongue was developed for the detection of lactose content in commercial foods. This was accomplished by employing optimized detection units comprised of gelatin films and information visualization methods for data analysis. The films incorporating gelatin, tannic acid, and zein, served as the basis for the sensors, whose electrodes were screen printed using carbon black ink. Self-supporting films were produced using various combinations of these materials, some of which had limited solubility in water (from 33% to 36%). They were hydrophobic and yielded reproducible electrical impedance spectra to be used as sensing units. Lactose detection experiments were conducted using various standard concentrations and commercial food samples. Capacitance decreased with lactose concentration at low frequencies, with films lacking a hydrophobic coating showing higher capacitance signals (exceeding 200 nF). Low limits of detection were obtained for the most sensitive films, as low as 2.03 × 10−19 mol/L, comparable to existing biosensors to detect lactose. Combining data from four sensing units in an electronic tongue allowed for the differentiation of lactose concentrations ranging from 1 × 10−20 mol/L to 1 × 10−6 mol/L using the interactive document mapping (IDMAP) projection technique, leading to a silhouette coefficient of 0.716. The discriminatory power of the electronic tongue was validated by distinguishing between lactose-containing and lactose-free food products. These findings highlight the potential of electronic tongues made with sustainable materials for applications in food quality assessment and lactose intolerance management.
{"title":"Electronic tongue made of gelatin self-supporting films on printed electrodes to detect lactose","authors":"Ana C. V. Piccinin, Andrey Coatrini-Soares, Giuliana T. Franco, T. J. Bondancia, Juliana Coatrini-Soares, Osvaldo N. Oliveira, L. H. Mattoso","doi":"10.3389/fsens.2024.1401077","DOIUrl":"https://doi.org/10.3389/fsens.2024.1401077","url":null,"abstract":"An electronic tongue was developed for the detection of lactose content in commercial foods. This was accomplished by employing optimized detection units comprised of gelatin films and information visualization methods for data analysis. The films incorporating gelatin, tannic acid, and zein, served as the basis for the sensors, whose electrodes were screen printed using carbon black ink. Self-supporting films were produced using various combinations of these materials, some of which had limited solubility in water (from 33% to 36%). They were hydrophobic and yielded reproducible electrical impedance spectra to be used as sensing units. Lactose detection experiments were conducted using various standard concentrations and commercial food samples. Capacitance decreased with lactose concentration at low frequencies, with films lacking a hydrophobic coating showing higher capacitance signals (exceeding 200 nF). Low limits of detection were obtained for the most sensitive films, as low as 2.03 × 10−19 mol/L, comparable to existing biosensors to detect lactose. Combining data from four sensing units in an electronic tongue allowed for the differentiation of lactose concentrations ranging from 1 × 10−20 mol/L to 1 × 10−6 mol/L using the interactive document mapping (IDMAP) projection technique, leading to a silhouette coefficient of 0.716. The discriminatory power of the electronic tongue was validated by distinguishing between lactose-containing and lactose-free food products. These findings highlight the potential of electronic tongues made with sustainable materials for applications in food quality assessment and lactose intolerance management.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.3389/fsens.2024.1367992
Fabian Schwab, Mohamed El Arayshi, Seyedreza Rezaei, Hadrien Sprumont, Federico Allione, Claudio Mucignat, Ivan Lunati, C. M. Verrelli, A. Jusufi
Soft bio-mimetic robotics is a growing field of research that seeks to close the gap with animal robustness and adaptability where conventional robots fall short. The embedding of sensors with the capability to discriminate between different body deformation modes is a key technological challenge in soft robotics to enhance robot control–a difficult task for this type of systems with high degrees of freedom. The recently conceived Linear Repetitive Learning Estimation Scheme (LRLES)–to be included in the traditional Proportional–integral–derivative (PID) control–is proposed here as a way to compensate for uncertain dynamics on a soft swimming robot, which is actuated with soft pneumatic actuators and equipped with soft sensors providing proprioceptive information pertaining to lateral body caudal bending akin to a goniometer. The proposed controller is derived in detail and experimentally validated, with the experiment consisting of tracking a desired trajectory for the bending angle envelope while continuously oscillating with a constant frequency. The results are compared vis a vis those achieved with the traditional PID controller, finding that the PID endowed with the LRLES outperforms the PID controller (though the latter has been separately tuned) and experimentally validating the novel controller’s effectiveness, accuracy, and matching speed.
{"title":"Learning control for body caudal undulation with soft sensory feedback","authors":"Fabian Schwab, Mohamed El Arayshi, Seyedreza Rezaei, Hadrien Sprumont, Federico Allione, Claudio Mucignat, Ivan Lunati, C. M. Verrelli, A. Jusufi","doi":"10.3389/fsens.2024.1367992","DOIUrl":"https://doi.org/10.3389/fsens.2024.1367992","url":null,"abstract":"Soft bio-mimetic robotics is a growing field of research that seeks to close the gap with animal robustness and adaptability where conventional robots fall short. The embedding of sensors with the capability to discriminate between different body deformation modes is a key technological challenge in soft robotics to enhance robot control–a difficult task for this type of systems with high degrees of freedom. The recently conceived Linear Repetitive Learning Estimation Scheme (LRLES)–to be included in the traditional Proportional–integral–derivative (PID) control–is proposed here as a way to compensate for uncertain dynamics on a soft swimming robot, which is actuated with soft pneumatic actuators and equipped with soft sensors providing proprioceptive information pertaining to lateral body caudal bending akin to a goniometer. The proposed controller is derived in detail and experimentally validated, with the experiment consisting of tracking a desired trajectory for the bending angle envelope while continuously oscillating with a constant frequency. The results are compared vis a vis those achieved with the traditional PID controller, finding that the PID endowed with the LRLES outperforms the PID controller (though the latter has been separately tuned) and experimentally validating the novel controller’s effectiveness, accuracy, and matching speed.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.3389/fsens.2024.1410989
{"title":"Erratum: AI-boosted CRISPR-Cas13a and total internal reflection fluorescence microscopy system for SARS-CoV-2 detection","authors":"","doi":"10.3389/fsens.2024.1410989","DOIUrl":"https://doi.org/10.3389/fsens.2024.1410989","url":null,"abstract":"","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09DOI: 10.3389/fsens.2024.1302520
Hui Ma, Christine Loscher, Anne Parle-McDermott, Jenny Fitzgerald, Julie P. Meneely, Christopher Elliott, Richard Welten, G. Mchau, Edna Makule, Revocatus Lazaro Machunda, Yun Yun Gong, Martin Kimanya, Aoife S Crawley, Ivan Maguire, C. Murphy, Richard O’Kennedy
Introduction: Globally, the need for measuring exposure to algal toxins has become urgent due to ever-increasing reports of contamination in sea and freshwater, in shellfish and fish stocks and in aerosols.Methods: To address this issue, we evaluated the potential of determining autoantibodies to a panel of biomarkers known to be elevated following exposure to the hepatotoxin microcystin leucine-arginine. The presence of autoantibodies, specific to four selected stress-response, metabolomic and chaperone biomarkers, namely, Heat shock protein 1, Triosephosphate isomerase, Peroxiredoxin 1 and Peroxiredoxin 2 was employed in screening 371 serum samples from microcystin-exposed individuals in Tanzania. In addition, the capacity of the LightDeck fluorescence-based detector, a point-of-use device, to monitor these autoantibody responses in comparison to enzyme-linked immunosorbent assay was evaluated.Results: By using the determination of autoantibodies to this novel panel of biomarkers an altered response was observed following microcystin exposure, with levels generally upregulated. The presence of elevated levels of microcystin leucine-arginine in water, as well as in food sources in Tanzania, may potentially have significant health effects on the population.Discussion: This novel biomarker panel may have potential for the detection of microcystin leucine-arginine exposure as well as various microcystin exposure-associated cancers (e.g., hepatocellular cancer and colorectal cancer). In addition, the utilisation of the LightDeck point-of-use device proved successful for the rapid analysis of this biomarker panel.
{"title":"Evaluation of a point-of-use device used for autoantibody analysis and its potential for following microcystin leucine-arginine exposure","authors":"Hui Ma, Christine Loscher, Anne Parle-McDermott, Jenny Fitzgerald, Julie P. Meneely, Christopher Elliott, Richard Welten, G. Mchau, Edna Makule, Revocatus Lazaro Machunda, Yun Yun Gong, Martin Kimanya, Aoife S Crawley, Ivan Maguire, C. Murphy, Richard O’Kennedy","doi":"10.3389/fsens.2024.1302520","DOIUrl":"https://doi.org/10.3389/fsens.2024.1302520","url":null,"abstract":"Introduction: Globally, the need for measuring exposure to algal toxins has become urgent due to ever-increasing reports of contamination in sea and freshwater, in shellfish and fish stocks and in aerosols.Methods: To address this issue, we evaluated the potential of determining autoantibodies to a panel of biomarkers known to be elevated following exposure to the hepatotoxin microcystin leucine-arginine. The presence of autoantibodies, specific to four selected stress-response, metabolomic and chaperone biomarkers, namely, Heat shock protein 1, Triosephosphate isomerase, Peroxiredoxin 1 and Peroxiredoxin 2 was employed in screening 371 serum samples from microcystin-exposed individuals in Tanzania. In addition, the capacity of the LightDeck fluorescence-based detector, a point-of-use device, to monitor these autoantibody responses in comparison to enzyme-linked immunosorbent assay was evaluated.Results: By using the determination of autoantibodies to this novel panel of biomarkers an altered response was observed following microcystin exposure, with levels generally upregulated. The presence of elevated levels of microcystin leucine-arginine in water, as well as in food sources in Tanzania, may potentially have significant health effects on the population.Discussion: This novel biomarker panel may have potential for the detection of microcystin leucine-arginine exposure as well as various microcystin exposure-associated cancers (e.g., hepatocellular cancer and colorectal cancer). In addition, the utilisation of the LightDeck point-of-use device proved successful for the rapid analysis of this biomarker panel.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"120 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09DOI: 10.3389/fsens.2024.1302520
Hui Ma, Christine Loscher, Anne Parle-McDermott, Jenny Fitzgerald, Julie P. Meneely, Christopher Elliott, Richard Welten, G. Mchau, Edna Makule, Revocatus Lazaro Machunda, Yun Yun Gong, Martin Kimanya, Aoife S Crawley, Ivan Maguire, C. Murphy, Richard O’Kennedy
Introduction: Globally, the need for measuring exposure to algal toxins has become urgent due to ever-increasing reports of contamination in sea and freshwater, in shellfish and fish stocks and in aerosols.Methods: To address this issue, we evaluated the potential of determining autoantibodies to a panel of biomarkers known to be elevated following exposure to the hepatotoxin microcystin leucine-arginine. The presence of autoantibodies, specific to four selected stress-response, metabolomic and chaperone biomarkers, namely, Heat shock protein 1, Triosephosphate isomerase, Peroxiredoxin 1 and Peroxiredoxin 2 was employed in screening 371 serum samples from microcystin-exposed individuals in Tanzania. In addition, the capacity of the LightDeck fluorescence-based detector, a point-of-use device, to monitor these autoantibody responses in comparison to enzyme-linked immunosorbent assay was evaluated.Results: By using the determination of autoantibodies to this novel panel of biomarkers an altered response was observed following microcystin exposure, with levels generally upregulated. The presence of elevated levels of microcystin leucine-arginine in water, as well as in food sources in Tanzania, may potentially have significant health effects on the population.Discussion: This novel biomarker panel may have potential for the detection of microcystin leucine-arginine exposure as well as various microcystin exposure-associated cancers (e.g., hepatocellular cancer and colorectal cancer). In addition, the utilisation of the LightDeck point-of-use device proved successful for the rapid analysis of this biomarker panel.
{"title":"Evaluation of a point-of-use device used for autoantibody analysis and its potential for following microcystin leucine-arginine exposure","authors":"Hui Ma, Christine Loscher, Anne Parle-McDermott, Jenny Fitzgerald, Julie P. Meneely, Christopher Elliott, Richard Welten, G. Mchau, Edna Makule, Revocatus Lazaro Machunda, Yun Yun Gong, Martin Kimanya, Aoife S Crawley, Ivan Maguire, C. Murphy, Richard O’Kennedy","doi":"10.3389/fsens.2024.1302520","DOIUrl":"https://doi.org/10.3389/fsens.2024.1302520","url":null,"abstract":"Introduction: Globally, the need for measuring exposure to algal toxins has become urgent due to ever-increasing reports of contamination in sea and freshwater, in shellfish and fish stocks and in aerosols.Methods: To address this issue, we evaluated the potential of determining autoantibodies to a panel of biomarkers known to be elevated following exposure to the hepatotoxin microcystin leucine-arginine. The presence of autoantibodies, specific to four selected stress-response, metabolomic and chaperone biomarkers, namely, Heat shock protein 1, Triosephosphate isomerase, Peroxiredoxin 1 and Peroxiredoxin 2 was employed in screening 371 serum samples from microcystin-exposed individuals in Tanzania. In addition, the capacity of the LightDeck fluorescence-based detector, a point-of-use device, to monitor these autoantibody responses in comparison to enzyme-linked immunosorbent assay was evaluated.Results: By using the determination of autoantibodies to this novel panel of biomarkers an altered response was observed following microcystin exposure, with levels generally upregulated. The presence of elevated levels of microcystin leucine-arginine in water, as well as in food sources in Tanzania, may potentially have significant health effects on the population.Discussion: This novel biomarker panel may have potential for the detection of microcystin leucine-arginine exposure as well as various microcystin exposure-associated cancers (e.g., hepatocellular cancer and colorectal cancer). In addition, the utilisation of the LightDeck point-of-use device proved successful for the rapid analysis of this biomarker panel.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-25DOI: 10.3389/fsens.2023.1328490
C. M. Gómez-Sarabia, Jorge Ojeda-Castañeda
The Talbot effect and the Lau effect have been usefully applied in optical interferometry, and for designing novel X-ray devices, as well as for implementing useful instruments for matter waves. In temporal optics, the above phenomena play a significant role for reconstructing modulated, optical short pulses that travel along a dispersive medium. We note that the Talbot-Lau devices can be spatial frequency tuned if one employs varifocal lenses as a nonmechanical technique. Thus, we identify a pertinent link between the Talbot-Lau sensors and the development of artificial muscle materials, for generating tunable lenses. Our discussion unifies seemly unrelated topics, for providing a global scope on the applications of the Talbot-Lau effect.
塔尔博特效应和劳氏效应已被有效地应用于光学干涉测量、新型 X 射线装置的设计以及物质波有用仪器的制造。在时间光学中，上述现象在重建沿着色散介质传播的调制光学短脉冲时发挥着重要作用。我们注意到，如果采用变焦透镜这种非机械技术，塔尔博特-劳装置可以进行空间频率调整。因此，我们确定了塔尔博特-劳传感器与人工肌肉材料开发之间的相关联系，以生成可调透镜。我们的讨论将看似不相关的话题统一起来，为塔尔博特-劳效应的应用提供了一个全球范围。
{"title":"Talbot-Lau devices: a reappraisal","authors":"C. M. Gómez-Sarabia, Jorge Ojeda-Castañeda","doi":"10.3389/fsens.2023.1328490","DOIUrl":"https://doi.org/10.3389/fsens.2023.1328490","url":null,"abstract":"The Talbot effect and the Lau effect have been usefully applied in optical interferometry, and for designing novel X-ray devices, as well as for implementing useful instruments for matter waves. In temporal optics, the above phenomena play a significant role for reconstructing modulated, optical short pulses that travel along a dispersive medium. We note that the Talbot-Lau devices can be spatial frequency tuned if one employs varifocal lenses as a nonmechanical technique. Thus, we identify a pertinent link between the Talbot-Lau sensors and the development of artificial muscle materials, for generating tunable lenses. Our discussion unifies seemly unrelated topics, for providing a global scope on the applications of the Talbot-Lau effect.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139597708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-18DOI: 10.3389/fsens.2023.1317533
W. Reimringer, Christian Bur
Recent advancements in metal oxide semiconductor sensors enable system integrators to make sensor devices without the traditional complications of operating barebone sensor components. Anyone, so it seems, can put together multi-sensor-systems by combining an integrated sensor subsystem with a small piece of digital infrastructure, resulting in low-cost sensor systems or sensor networks for all kinds of applications. With low energy consumption, the deployment of close meshed sensor networks is becoming a reality, promising high density data for big data models. However, data quality is not necessarily a feature of such devices, since the device output signals are heavily processed and the insight into the actual operating technique is black-boxed by the respective sensor manufacturer. High volume production of a sensor model requires widely applicable output information, yet this mainstreaming negatively impacts quality control efforts on the system level as well as niche applications that require specialized operation modes. This article exemplarily examines the measurement chain of typical metal oxide semiconductor sensor applications and deduces requirements for a technically sound advancement of the subject for research and commercial purposes. Equivalent considerations can be made for any low-cost sensor principle and their respective challenges. The conclusion urges all stakeholders participating in the development and marketing of sensor devices to advance a scientifically valid state of knowledge and to educate their customers and even the general public accordingly.
{"title":"Promoting quality in low-cost gas sensor devices for real-world applications","authors":"W. Reimringer, Christian Bur","doi":"10.3389/fsens.2023.1317533","DOIUrl":"https://doi.org/10.3389/fsens.2023.1317533","url":null,"abstract":"Recent advancements in metal oxide semiconductor sensors enable system integrators to make sensor devices without the traditional complications of operating barebone sensor components. Anyone, so it seems, can put together multi-sensor-systems by combining an integrated sensor subsystem with a small piece of digital infrastructure, resulting in low-cost sensor systems or sensor networks for all kinds of applications. With low energy consumption, the deployment of close meshed sensor networks is becoming a reality, promising high density data for big data models. However, data quality is not necessarily a feature of such devices, since the device output signals are heavily processed and the insight into the actual operating technique is black-boxed by the respective sensor manufacturer. High volume production of a sensor model requires widely applicable output information, yet this mainstreaming negatively impacts quality control efforts on the system level as well as niche applications that require specialized operation modes. This article exemplarily examines the measurement chain of typical metal oxide semiconductor sensor applications and deduces requirements for a technically sound advancement of the subject for research and commercial purposes. Equivalent considerations can be made for any low-cost sensor principle and their respective challenges. The conclusion urges all stakeholders participating in the development and marketing of sensor devices to advance a scientifically valid state of knowledge and to educate their customers and even the general public accordingly.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.3389/fsens.2023.1327240
F. Schaumburg, C. Berli
A broad spectrum of application fields, including human and animal health, food safety and environmental monitoring, require performing real time, on-field chemical determinations, a concept known as point-of-need testing (PONT). In the case of infectious diseases, it allows for early diagnosis, which usually enables better treatment options for the patient, and permits early outbreak detection and intervention with proper control measures. PONT solutions are usually developed on microfluidic chips, preferably with no extra equipment, as to lower their cost, ease their delivery and portability. However, equipment-free PONT is not always feasible, since off-chip operations (e.g., pumping or heating) might be required and provided by the so-called analyzers. A typical example is the hardware for optical reading, which is the subject of this perspective article. Firstly, the state-of-the-art is briefly analyzed considering the solutions provided by both academy and industry. Special emphasis is made on the smartphone-based approaches that use no additional hardware (add-ons) for optical reading. Smartphones are the straightforward option, since they can replace a number of operations typically done by analyzers. The issues arising from using smartphones without add-ons are classified into variability sources and technical challenges. Finally, a set of methods for dealing with these challenges is proposed and briefly discussed. Simpler systems will be more easily adopted by more users, for a broader range of application cases, and will let PONT be a more powerful tool for improving disease diagnosis and outbreak management.
包括人类和动物健康、食品安全和环境监测在内的众多应用领域都需要进行实时现场化学测定，这一概念被称为需求点测试（PONT）。就传染病而言，PONT 可以进行早期诊断，从而为病人提供更好的治疗方案，并能及早发现疫情，采取适当的控制措施进行干预。PONT 解决方案通常是在微流控芯片上开发的，最好不需要额外的设备，以降低成本、便于交付和携带。不过，无设备 PONT 并不总是可行的，因为可能需要芯片外操作（如泵送或加热），并由所谓的分析仪提供。光学读取硬件就是一个典型的例子，也是本视角文章的主题。首先，我们简要分析了学术界和工业界提供的最新解决方案。其中特别强调了基于智能手机的方法，这种方法不使用光学读取的额外硬件（附加组件）。智能手机是最直接的选择，因为它可以取代通常由分析仪完成的许多操作。使用不带附加装置的智能手机所产生的问题分为可变性来源和技术挑战。最后，提出了一套应对这些挑战的方法，并进行了简要讨论。更简单的系统将更容易被更多用户采用，应用范围更广，并使 PONT 成为改进疾病诊断和疫情管理的更强大工具。
{"title":"Challenges and proposed solutions for optical reading on point-of-need testing systems","authors":"F. Schaumburg, C. Berli","doi":"10.3389/fsens.2023.1327240","DOIUrl":"https://doi.org/10.3389/fsens.2023.1327240","url":null,"abstract":"A broad spectrum of application fields, including human and animal health, food safety and environmental monitoring, require performing real time, on-field chemical determinations, a concept known as point-of-need testing (PONT). In the case of infectious diseases, it allows for early diagnosis, which usually enables better treatment options for the patient, and permits early outbreak detection and intervention with proper control measures. PONT solutions are usually developed on microfluidic chips, preferably with no extra equipment, as to lower their cost, ease their delivery and portability. However, equipment-free PONT is not always feasible, since off-chip operations (e.g., pumping or heating) might be required and provided by the so-called analyzers. A typical example is the hardware for optical reading, which is the subject of this perspective article. Firstly, the state-of-the-art is briefly analyzed considering the solutions provided by both academy and industry. Special emphasis is made on the smartphone-based approaches that use no additional hardware (add-ons) for optical reading. Smartphones are the straightforward option, since they can replace a number of operations typically done by analyzers. The issues arising from using smartphones without add-ons are classified into variability sources and technical challenges. Finally, a set of methods for dealing with these challenges is proposed and briefly discussed. Simpler systems will be more easily adopted by more users, for a broader range of application cases, and will let PONT be a more powerful tool for improving disease diagnosis and outbreak management.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"244 4‐5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-05DOI: 10.3389/fsens.2023.1294721
Monique Bax, Jordan Thorpe, Valentin Romanov
Cardiovascular diseases remain the most lethal disorders worldwide. Employing preeminent techniques is paramount for addressing this global challenge. Recent advances in lab-on-a-chip technology have the potential to transform cardiovascular medicine by providing new tools for understanding the biological variability that underlies disease and drug response. Coupling improved fabrication techniques and cardiovascular cellular models with artificial intelligence-based tools for design and analysis primes the field to model and explore cardiovascular biology more accurately than ever before. The fabrication of lab-on-a-chip systems has dramatically evolved with the development of additive manufacturing technologies. Not only can 3D printing be used to fabricate intricate microfluidic networks, but now through the incorporation of smart materials, 4D printing can change the shape and properties of devices based on external stimuli. By leveraging advances in induced pluripotent stem cells, lab-on-a-chip devices open new opportunities within personalized cardiovascular medicine. As customizable systems, devices can be fabricated and populated with donor stem cell-derived cardiovascular cells to mimic the cardiovascular system. These capabilities are only going to improve with the increasingly important role of artificial intelligence in lab-on-a-chip centric design, real-time analysis, data gathering, processing and analysis. Here, we address the potential to personalize cardiovascular medicine through the lens of advances in the fabrication of lab-on-a-chip devices, development of induced pluripotent stem cells derived engineered vasculature and heart tissues, and explore how artificial intelligence continues to shape this field.
{"title":"The future of personalized cardiovascular medicine demands 3D and 4D printing, stem cells, and artificial intelligence","authors":"Monique Bax, Jordan Thorpe, Valentin Romanov","doi":"10.3389/fsens.2023.1294721","DOIUrl":"https://doi.org/10.3389/fsens.2023.1294721","url":null,"abstract":"Cardiovascular diseases remain the most lethal disorders worldwide. Employing preeminent techniques is paramount for addressing this global challenge. Recent advances in lab-on-a-chip technology have the potential to transform cardiovascular medicine by providing new tools for understanding the biological variability that underlies disease and drug response. Coupling improved fabrication techniques and cardiovascular cellular models with artificial intelligence-based tools for design and analysis primes the field to model and explore cardiovascular biology more accurately than ever before. The fabrication of lab-on-a-chip systems has dramatically evolved with the development of additive manufacturing technologies. Not only can 3D printing be used to fabricate intricate microfluidic networks, but now through the incorporation of smart materials, 4D printing can change the shape and properties of devices based on external stimuli. By leveraging advances in induced pluripotent stem cells, lab-on-a-chip devices open new opportunities within personalized cardiovascular medicine. As customizable systems, devices can be fabricated and populated with donor stem cell-derived cardiovascular cells to mimic the cardiovascular system. These capabilities are only going to improve with the increasingly important role of artificial intelligence in lab-on-a-chip centric design, real-time analysis, data gathering, processing and analysis. Here, we address the potential to personalize cardiovascular medicine through the lens of advances in the fabrication of lab-on-a-chip devices, development of induced pluripotent stem cells derived engineered vasculature and heart tissues, and explore how artificial intelligence continues to shape this field.","PeriodicalId":93754,"journal":{"name":"Frontiers in sensors","volume":"42 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138600490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：