Pub Date : 2021-09-01DOI: 10.1097/hm9.0000000000000009
Xuemin Shi
{"title":"Study of the relationship between acupuncture dose and effect","authors":"Xuemin Shi","doi":"10.1097/hm9.0000000000000009","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000009","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73694313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.1097/HM9.0000000000000004
Kouharu Otsuki, Mi Zhang, Wei Li
Abstract Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus (HIV) replication and transforming HIV infection from a fatal disease to a manageable chronic disease. However, the latent HIV reservoir persists in the body of HIV-infected individuals and is prone to reactivation. Therefore, the development of new treatment methods aimed at a complete cure for HIV is needed. The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as “shock and kill.” This strategy involves the use of latency-reversing agents (LRAs) to activate the HIV provirus in latent viral reservoir cells. Many LRAs can be obtained from natural resources, including plants and marine organisms. In this review, we provide an overview of natural products used to eliminate HIV latency.
{"title":"Natural products against HIV latency","authors":"Kouharu Otsuki, Mi Zhang, Wei Li","doi":"10.1097/HM9.0000000000000004","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000004","url":null,"abstract":"Abstract Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus (HIV) replication and transforming HIV infection from a fatal disease to a manageable chronic disease. However, the latent HIV reservoir persists in the body of HIV-infected individuals and is prone to reactivation. Therefore, the development of new treatment methods aimed at a complete cure for HIV is needed. The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as “shock and kill.” This strategy involves the use of latency-reversing agents (LRAs) to activate the HIV provirus in latent viral reservoir cells. Many LRAs can be obtained from natural resources, including plants and marine organisms. In this review, we provide an overview of natural products used to eliminate HIV latency.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89617343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Traumatic brain injury (TBI) is a brain injury caused by direct external forces, and its prognosis depends on the extent of the damage and the changes in level of consciousness. Timely awakening from a coma is the first thorny problem to be solved in TBI treatment. Therefore, there is a need for the development of safe and effective methods for timely awakening after TBI coma. Dopamine (DA) and its receptors in the nervous system are involved in the regulation of wakefulness. The amount and activity of dopaminergic neurons can affect cellular function and neuroinflammatory response, and are also significant for the awakening process after TBI. The current common awakening therapy for TBI may also be related to the activation of dopaminergic neurons. Acupuncture plays a beneficial role in timely awakening, recovery of conscious level, and functional rehabilitation after TBI. The mechanism may be related to the targeted regulation of DA and its receptors via acupuncture. Among acupuncture first aid therapies, acupuncture at hand 12 Jing-Well points, with its advantages of simple operation and ultra-early intervention, has shown great promise in timely awakening following TBI and triggering a series of subsequent nerve repair effects in the treatment of TBI. We here present a review that provides a new perspective for the timely awakening from TBI-induced coma, with a focus on the role of DA in the regulation of wakefulness and the efficacy and potential mechanism of DA systems in the treatment of TBI by acupuncture.
{"title":"Arousal effect and potential mechanism of dopamine-mediated acupuncture on traumatic brain injury","authors":"Yadan Zhao, Yuxin Fang, Zichen Zhang, Jingyi Liu, Siru Qin, Wei Li, Songtao Wang, Yi-song Guo, Zhifang Xu, Luis Ulloa","doi":"10.1097/HM9.0000000000000005","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000005","url":null,"abstract":"Abstract Traumatic brain injury (TBI) is a brain injury caused by direct external forces, and its prognosis depends on the extent of the damage and the changes in level of consciousness. Timely awakening from a coma is the first thorny problem to be solved in TBI treatment. Therefore, there is a need for the development of safe and effective methods for timely awakening after TBI coma. Dopamine (DA) and its receptors in the nervous system are involved in the regulation of wakefulness. The amount and activity of dopaminergic neurons can affect cellular function and neuroinflammatory response, and are also significant for the awakening process after TBI. The current common awakening therapy for TBI may also be related to the activation of dopaminergic neurons. Acupuncture plays a beneficial role in timely awakening, recovery of conscious level, and functional rehabilitation after TBI. The mechanism may be related to the targeted regulation of DA and its receptors via acupuncture. Among acupuncture first aid therapies, acupuncture at hand 12 Jing-Well points, with its advantages of simple operation and ultra-early intervention, has shown great promise in timely awakening following TBI and triggering a series of subsequent nerve repair effects in the treatment of TBI. We here present a review that provides a new perspective for the timely awakening from TBI-induced coma, with a focus on the role of DA in the regulation of wakefulness and the efficacy and potential mechanism of DA systems in the treatment of TBI by acupuncture.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89052865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supplemental Digital Content is available in the text Abstract Objective: Swertia pseudochinensis, an annual herb of the genus Swertia in the family Gentianaceae. Some constituents and extracts from the Swertia genus have been recently reported to possess neuroprotective effects, suggesting their potential utility in the prevention and treatment of Parkinson disease (PD). The aim of this work is to identify the chemical constituents and evaluate the potential biological activists of Swertia pseudochinensis. Methods: The phytochemicals from the aerial parts of S. pseudochinensis were isolated and purified by silica gel, Sephadex LH-20 gel, semi-preparative high-performance liquid chromatography, and identified by the spectroscopic methods. All compounds were evaluated for their potential neuroprotective effects against 1-methyl-4-phenylpyridinium-induced apoptosis in the SH-SY5Y human neuroblastoma cell line using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay. Then, we performed an enrichment analysis using the Database for Annotation, Visualization, and Integrated Discovery and investigated the mechanisms by which bellidifolin regulates neurodegenerative disease. Results: Two new anthraquinone, 1,5,6-trimethoxy-2-hydroxy-3-methy-anthraquinone (1) and 1,5,6,8-tetramethoxy-2-hydroxy-3-methyanthraquinone (2), together with nine known including 7-O-β-d-glucopyranosyl-1,8-dihydroxy-3-methoxyxanthone (3), gentisin (4), swertianolin (5), bellidifolin (6), gentiacaulein (7), norswertianolin (8), 5-O-β-d-glucopyranosyl-1,3,8-trihydroxyapatone (9), 1-hydroxy-3,5,8-trimethoxyxanthone (10), and aurantio-obtusin (11), were isolated and compounds 6–8 and 10 exhibited neuroprotective effects at a concentration of 50 μmol/L. Among them, bellidifolin showed significant protective activity, and might have potential as a neuroprotective agent for the treatment of PD, possibly by acting on oxidative damage and reactive oxygen species. Conclusions: These findings indicate that further research on the genus Swertia and its bioactive constituents toward neurodegenerative disorders could be extremely rewarding.
摘要目的:龙胆科獐牙菜属一年生草本植物獐牙菜(Swertia pseudochinensis)。獐牙菜属的一些成分和提取物最近被报道具有神经保护作用，这表明它们在预防和治疗帕金森病(PD)方面具有潜在的用途。本研究的目的是鉴定伪中国獐牙菜的化学成分并评价其潜在的生物活性物质。方法:采用硅胶、Sephadex LH-20凝胶、半制备高效液相色谱等分离纯化方法，对伪南地上部植物化学成分进行鉴定。采用3-[4,5-二甲基噻唑-2-基]-2,5二苯基溴化四氮唑试验，评估所有化合物对1-甲基-4-苯吡啶诱导的SH-SY5Y人神经母细胞瘤细胞株凋亡的潜在神经保护作用。然后，我们使用Database for Annotation, Visualization, and Integrated Discovery进行了富集分析，并研究了bellidifolin调节神经退行性疾病的机制。结果:两个新的蒽醌，1,5,6-三甲氧基-2-羟基-3-甲基蒽醌(1)和1,5,6,8-四甲基氧基-2-羟基-3-甲氧基蒽醌(2)，以及已知的9种包括7- o- β-d-葡萄糖吡喃基-1,8-二羟基-3-甲氧基山酮(3)，龙胆素(4)，獐牙菜苷(5)，bellidifolin(6)，龙胆黄素(7)，去獐牙菜苷(8)，5- o- β-d-葡萄糖吡喃基-1,3,8-三羟基阿帕酮(9)，1-羟基-3,5,8-三甲氧基山酮(10)和aurantio-obtusin(11)。化合物6-8和10在浓度为50 μmol/L时表现出神经保护作用。其中，贝利迪福林显示出显著的保护活性，可能通过作用于氧化损伤和活性氧，有可能成为治疗PD的神经保护剂。结论:这些发现表明，进一步研究獐牙菜属及其对神经退行性疾病的生物活性成分可能是非常有益的。
{"title":"Chemical constituents isolated from the aerial parts of Swertia pseudochinensis and their potential neuroprotective effects","authors":"Ke Xiang, Qihui He, Yanmei Chen, Dongxin Yang, Yanwei Duan, Hua Li, Lixia Chen","doi":"10.1097/HM9.0000000000000010","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000010","url":null,"abstract":"Supplemental Digital Content is available in the text Abstract Objective: Swertia pseudochinensis, an annual herb of the genus Swertia in the family Gentianaceae. Some constituents and extracts from the Swertia genus have been recently reported to possess neuroprotective effects, suggesting their potential utility in the prevention and treatment of Parkinson disease (PD). The aim of this work is to identify the chemical constituents and evaluate the potential biological activists of Swertia pseudochinensis. Methods: The phytochemicals from the aerial parts of S. pseudochinensis were isolated and purified by silica gel, Sephadex LH-20 gel, semi-preparative high-performance liquid chromatography, and identified by the spectroscopic methods. All compounds were evaluated for their potential neuroprotective effects against 1-methyl-4-phenylpyridinium-induced apoptosis in the SH-SY5Y human neuroblastoma cell line using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay. Then, we performed an enrichment analysis using the Database for Annotation, Visualization, and Integrated Discovery and investigated the mechanisms by which bellidifolin regulates neurodegenerative disease. Results: Two new anthraquinone, 1,5,6-trimethoxy-2-hydroxy-3-methy-anthraquinone (1) and 1,5,6,8-tetramethoxy-2-hydroxy-3-methyanthraquinone (2), together with nine known including 7-O-β-d-glucopyranosyl-1,8-dihydroxy-3-methoxyxanthone (3), gentisin (4), swertianolin (5), bellidifolin (6), gentiacaulein (7), norswertianolin (8), 5-O-β-d-glucopyranosyl-1,3,8-trihydroxyapatone (9), 1-hydroxy-3,5,8-trimethoxyxanthone (10), and aurantio-obtusin (11), were isolated and compounds 6–8 and 10 exhibited neuroprotective effects at a concentration of 50 μmol/L. Among them, bellidifolin showed significant protective activity, and might have potential as a neuroprotective agent for the treatment of PD, possibly by acting on oxidative damage and reactive oxygen species. Conclusions: These findings indicate that further research on the genus Swertia and its bioactive constituents toward neurodegenerative disorders could be extremely rewarding.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82410180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objective: This study aimed to develop a core outcome set (COS) for use in future studies of stable angina pectoris (SAP) in traditional Chinese medicine (TCM). Methods: Systematic literature reviews and qualitative interviews with cardiologists and patients with SAP treated using TCM were conducted to generate a set of outcomes. Outcomes were prioritized by stakeholders via two rounds of an online Delphi survey and face-to-face consensus meetings. Following the final consensus meeting, a final COS was generated. Results: An initial set of 324 outcomes was identified. A preliminary list of 65 outcomes was employed in the Delphi study. In total, 223 participants from seven stakeholder groups were invited to score outcomes in the first Delphi round: 87 completed round 1 and 47 completed round 2. Thirty-one participants attended the consensus meeting and agreed on a final core set of outcomes comprising six items across four domains: frequency of angina attack, duration of angina attack, Seattle angina questionnaire, total exercise duration in the exercise treadmill test, cardiovascular events, and QT interval on electrocardiography. Conclusions: The COS developed in this study provides the minimum requirements for measurement and reporting in future TCM clinical trials for the treatment of SAP. The employment of this COS may reduce heterogeneity across trials and facilitate evidence-based decision-making for stakeholders.
{"title":"Core outcome set for stable angina pectoris in traditional Chinese medicine (COS-SAP-TCM)","authors":"Mingyan Zhang, Junhua Zhang, H. Chua, Rui Feng, Meijuan Lu, Ying Tian","doi":"10.1097/HM9.0000000000000007","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000007","url":null,"abstract":"Abstract Objective: This study aimed to develop a core outcome set (COS) for use in future studies of stable angina pectoris (SAP) in traditional Chinese medicine (TCM). Methods: Systematic literature reviews and qualitative interviews with cardiologists and patients with SAP treated using TCM were conducted to generate a set of outcomes. Outcomes were prioritized by stakeholders via two rounds of an online Delphi survey and face-to-face consensus meetings. Following the final consensus meeting, a final COS was generated. Results: An initial set of 324 outcomes was identified. A preliminary list of 65 outcomes was employed in the Delphi study. In total, 223 participants from seven stakeholder groups were invited to score outcomes in the first Delphi round: 87 completed round 1 and 47 completed round 2. Thirty-one participants attended the consensus meeting and agreed on a final core set of outcomes comprising six items across four domains: frequency of angina attack, duration of angina attack, Seattle angina questionnaire, total exercise duration in the exercise treadmill test, cardiovascular events, and QT interval on electrocardiography. Conclusions: The COS developed in this study provides the minimum requirements for measurement and reporting in future TCM clinical trials for the treatment of SAP. The employment of this COS may reduce heterogeneity across trials and facilitate evidence-based decision-making for stakeholders.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87623784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.1097/HM9.0000000000000003
Zhiyong Du, Zeliu Shu, Chun Li, Xiao-Min Song, Xiaoli Ma, Li-xi Liao, Jun Li, P. Tu, K. Zeng, Yong Jiang
Supplemental Digital Content is available in the text Abstract Objective: Baoyuan decoction (BYD) is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological tests. The present study aimed to investigate the effect and mechanism of BYD on alleviating myocardial infarction (MI). Methods: Nuclear magnetic resonance-based serum and urinary metabolomics were employed to explore the metabolic regulation effects of BYD in rats with MI induced by left anterior descending ligation. Oxygen-glucose deprivation/recovery (OGD/R) model in H9c2 cells and multiple molecular biology approaches were used to clarify the underlying action mechanisms of BYD. Results: BYD treatment recovered the serum and urinary metabolite profiles of the MI rats toward normal metabolic status and significantly improved mitochondrial energy metabolism and apoptosis pathways perturbed by MI. Analysis of the molecular mechanism of BYD indicated that it suppressed OGD/R-induced H9c2 cell apoptosis in a concentration-dependent manner by inhibiting the mitochondria-dependent caspase-9/3-poly ADP-ribose polymerase pathway. Conclusions: Our results demonstrate that BYD protects against myocardial apoptosis via the mitochondrial metabolic and apoptosis pathways. They also provide novel insights into the clinical application of BYD for the treatment of ischemic heart diseases.
{"title":"Baoyuan decoction alleviates myocardial infarction through the regulation of metabolic dysfunction and the mitochondria-dependent caspase-9/3 pathway","authors":"Zhiyong Du, Zeliu Shu, Chun Li, Xiao-Min Song, Xiaoli Ma, Li-xi Liao, Jun Li, P. Tu, K. Zeng, Yong Jiang","doi":"10.1097/HM9.0000000000000003","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000003","url":null,"abstract":"Supplemental Digital Content is available in the text Abstract Objective: Baoyuan decoction (BYD) is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological tests. The present study aimed to investigate the effect and mechanism of BYD on alleviating myocardial infarction (MI). Methods: Nuclear magnetic resonance-based serum and urinary metabolomics were employed to explore the metabolic regulation effects of BYD in rats with MI induced by left anterior descending ligation. Oxygen-glucose deprivation/recovery (OGD/R) model in H9c2 cells and multiple molecular biology approaches were used to clarify the underlying action mechanisms of BYD. Results: BYD treatment recovered the serum and urinary metabolite profiles of the MI rats toward normal metabolic status and significantly improved mitochondrial energy metabolism and apoptosis pathways perturbed by MI. Analysis of the molecular mechanism of BYD indicated that it suppressed OGD/R-induced H9c2 cell apoptosis in a concentration-dependent manner by inhibiting the mitochondria-dependent caspase-9/3-poly ADP-ribose polymerase pathway. Conclusions: Our results demonstrate that BYD protects against myocardial apoptosis via the mitochondrial metabolic and apoptosis pathways. They also provide novel insights into the clinical application of BYD for the treatment of ischemic heart diseases.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80922792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01DOI: 10.1097/hm9.0000000000000013
Bo-li Zhang
{"title":"Acupuncture and Herbal Medicine launched: building a bridge between traditional and modern medicine","authors":"Bo-li Zhang","doi":"10.1097/hm9.0000000000000013","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000013","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74697885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, traditional Chinese medicine-based treatment has succeeded in fighting coronavirus disease 2019 (COVID-19), and Rhizoma polygonati (Huangjing) has been one of the recommended components. Its processed products play antidiabetic, antiviral, antitumor, antioxidation, antifatigue, antiaging, and immune enhancement roles. The climate in Mount Tai is mild, and the dense forest is suitable for the growth of Rhizome polygonati, which has gradually evolved into a unique specie. Considering the important medicinal value and pleasant taste of Mount Tai-Rhizoma polygonati, various healthy and functional food products, controlled by quality markers with anti-COVID-19 potential, as well as emergency foods can be developed. The study aimed to review current evidence on the nutritional value of Rhizoma polygonati from Mount Tai and its usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and food shortage. Most recent findings regarding herbal nanomedicine have revealed that nanoscale chemical compounds are potentially efficient in drug delivery or nanozyme catalysis upon bioprocessing. Nanoflower structure is found in processed Rhizoma polygonati by self-assembly and has wide application in enzymatic events, particularly nanoscale herbzyme. The novel findings regarding Mount Tai-Rhizoma polygonati could enhance its novel applications in chronic and hidden hunger, clinical nanomedicine, and as an anti-COVID-19 agent.
{"title":"<i>Rhizoma polygonati</i> from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger.","authors":"Lazzat Nurtay, Qinglei Sun, Chenglin Mu, Zhongshan Cao, Qian Wang, Zongsuo Liang, Cuiping Ma, Xugang Li, Amr Amin, Yingqiu Xie","doi":"10.1097/HM9.0000000000000008","DOIUrl":"10.1097/HM9.0000000000000008","url":null,"abstract":"<p><p>Recently, traditional Chinese medicine-based treatment has succeeded in fighting coronavirus disease 2019 (COVID-19), and <i>Rhizoma polygonati</i> (Huangjing) has been one of the recommended components. Its processed products play antidiabetic, antiviral, antitumor, antioxidation, antifatigue, antiaging, and immune enhancement roles. The climate in Mount Tai is mild, and the dense forest is suitable for the growth of <i>Rhizome polygonati,</i> which has gradually evolved into a unique specie. Considering the important medicinal value and pleasant taste of Mount Tai<i>-Rhizoma polygonati,</i> various healthy and functional food products, controlled by quality markers with anti-COVID-19 potential, as well as emergency foods can be developed. The study aimed to review current evidence on the nutritional value of <i>Rhizoma polygonati</i> from Mount Tai and its usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and food shortage. Most recent findings regarding herbal nanomedicine have revealed that nanoscale chemical compounds are potentially efficient in drug delivery or nanozyme catalysis upon bioprocessing. Nanoflower structure is found in processed <i>Rhizoma polygonati</i> by self-assembly and has wide application in enzymatic events, particularly nanoscale herbzyme. The novel findings regarding Mount <i>Tai-Rhizoma polygonati</i> could enhance its novel applications in chronic and hidden hunger, clinical nanomedicine, and as an anti-COVID-19 agent.</p>","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/16/hm9-1-31.PMC9380154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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