首页 > 最新文献

Ear, nose, & throat journal最新文献

英文 中文
Clinical Outcomes After Innovative Multipoint Impedance-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis. 创新性多点阻抗控制射频消融术治疗慢性鼻炎后的临床疗效。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241285134
Greg E Davis, Randall A Ow, David M Yen, Ellen M O'Malley, Anthony G Del Signore

Objective: Chronic rhinitis substantially impacts a person's quality of life. We evaluated a novel, multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Methods: This was a prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis. The primary efficacy endpoint was the change in reflective Total Nasal Symptom Score (rTNSS) at 6-month follow-up. Additional assessments included the Eustachian Tube Dysfunction Questionnaire (ETDQ-7), Nasal Obstruction Symptom Evaluation (NOSE), and mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ). The primary safety endpoint was the incidence of related serious adverse events. Results: Seventy-nine of 80 enrolled participants completed 6-month follow-up. Statistically significant improvements were observed for mean change in rTNSS (-4.2), ETDQ-7 (-1.2), NOSE (-33.5), and mini-RQLQ (-1.8; P < .0001 for all). Allergic and nonallergic rhinitis subgroups demonstrated significant improvement in all assessments (P < .0001) with no significant differences between subgroups. Higher baseline rTNSS was associated with greater improvements at follow-up. One serious adverse event of epistaxis was reported. Conclusions: The results of this study demonstrate the efficacy and safety of a multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Significant improvements were observed in rTNSS, ETDQ-7, NOSE, and mini-RQLQ assessments.Study registration: www.clinicaltrials.gov. Unique identifier NCT05591989.

目的:慢性鼻炎严重影响患者的生活质量。我们对用于治疗慢性鼻炎的新型多点阻抗控制射频消融设备进行了评估。研究方法这是一项前瞻性、多中心、单臂临床研究,针对慢性鼻炎成人患者的后鼻神经消融术。主要疗效终点是随访 6 个月时反映性鼻症状总评分(rTNSS)的变化。其他评估包括咽鼓管功能障碍问卷(ETDQ-7)、鼻阻塞症状评估(NOSE)和迷你鼻结膜炎生活质量问卷(mini-RQLQ)。主要安全性终点是相关严重不良事件的发生率。研究结果80 名注册参与者中有 79 人完成了为期 6 个月的随访。rTNSS(-4.2)、ETDQ-7(-1.2)、NOSE(-33.5)和迷你 RQLQ(-1.8;P < .0001)的平均变化均有统计学意义的明显改善。过敏性鼻炎亚组和非过敏性鼻炎亚组在所有评估中均有显著改善(P < .0001),亚组之间无明显差异。基线 rTNSS 越高,随访时的改善程度越大。报告了一起鼻衄的严重不良事件。结论:这项研究结果证明了多点阻抗控制射频消融设备治疗慢性鼻炎的有效性和安全性。在rTNSS、ETDQ-7、NOSE和mini-RQLQ评估中观察到显著改善。研究注册:www.clinicaltrials.gov。唯一标识符 NCT05591989。
{"title":"Clinical Outcomes After Innovative Multipoint Impedance-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis.","authors":"Greg E Davis, Randall A Ow, David M Yen, Ellen M O'Malley, Anthony G Del Signore","doi":"10.1177/01455613241285134","DOIUrl":"https://doi.org/10.1177/01455613241285134","url":null,"abstract":"<p><p><b>Objective:</b> Chronic rhinitis substantially impacts a person's quality of life. We evaluated a novel, multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. <b>Methods:</b> This was a prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis. The primary efficacy endpoint was the change in reflective Total Nasal Symptom Score (rTNSS) at 6-month follow-up. Additional assessments included the Eustachian Tube Dysfunction Questionnaire (ETDQ-7), Nasal Obstruction Symptom Evaluation (NOSE), and mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ). The primary safety endpoint was the incidence of related serious adverse events. <b>Results:</b> Seventy-nine of 80 enrolled participants completed 6-month follow-up. Statistically significant improvements were observed for mean change in rTNSS (-4.2), ETDQ-7 (-1.2), NOSE (-33.5), and mini-RQLQ (-1.8; <i>P</i> < .0001 for all). Allergic and nonallergic rhinitis subgroups demonstrated significant improvement in all assessments (<i>P</i> < .0001) with no significant differences between subgroups. Higher baseline rTNSS was associated with greater improvements at follow-up. One serious adverse event of epistaxis was reported. <b>Conclusions:</b> The results of this study demonstrate the efficacy and safety of a multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Significant improvements were observed in rTNSS, ETDQ-7, NOSE, and mini-RQLQ assessments.<b>Study registration:</b> www.clinicaltrials.gov. Unique identifier NCT05591989.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Nasal Polyposis in Pediatric Patients With Cornelia de Lange Syndrome: A Case Series and Literature Review. 科尼莉亚-德-朗格综合征儿科患者鼻息肉病的治疗:病例系列和文献综述。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241284153
Ian F Caplan, Michael Ye, Aaron N Pearlman

Cornelia de Lange syndrome (CdLS) is a rare genetic multiple malformation disorder with many otolaryngologic comorbidities. Patients with CdLS appear to have an increased prevalence of chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP), however, there is limited literature describing the presentation, evaluation, and management of CRSwNP within the CdLS population. Here we performed a literature review from Embase, PubMed, Cochrane Library, and Google Scholar and reported a case of CRSwNP with concomitant CdLS that was identified at our institution. We describe an 8-year-old male with CdLS and CRSwNP confirmed by history, physical exam, nasal endoscopy, and computed tomography. Symptoms of nasal obstruction were refractory to medical management and required repeat surgical management with improvement in nasal obstruction. Literature review identified 2 additional cases of nasal polyposis with similar management strategies. Additionally, one case series showed 33% of CdLS patients had recurrent sinusitis while a second series identified 39% of CdLS patients with CRS and 12% with CRSwNP. These data suggest that CRSwNP is more prevalent in patients with CdLS compared to the general public and can be both safely and effectively managed with a combination of medical and surgical therapy.

科尼莉亚-德-朗格综合征(CdLS)是一种罕见的遗传性多发性畸形疾病,有许多耳鼻喉科合并症。CdLS 患者中,慢性鼻炎(CRS)和慢性鼻炎伴鼻息肉病(CRSwNP)的发病率似乎较高,但描述 CdLS 患者中 CRSwNP 的表现、评估和管理的文献却很有限。在此,我们对 Embase、PubMed、Cochrane 图书馆和谷歌学术进行了文献综述,并报告了本院发现的一例 CRSwNP 并发 CdLS 的病例。我们描述了一名 8 岁男性患者的病史、体格检查、鼻内窥镜检查和计算机断层扫描证实其患有 CdLS 和 CRSwNP。鼻塞症状经药物治疗无效,需要再次手术治疗,但鼻塞症状有所改善。文献综述发现,还有 2 例鼻息肉病例采取了类似的治疗策略。此外,一个病例系列显示 33% 的 CdLS 患者有复发性鼻窦炎,而第二个病例系列发现 39% 的 CdLS 患者有 CRS,12% 有 CRSwNP。这些数据表明,与普通人相比,CdLS 患者中 CRSwNP 的发病率更高,可以通过药物和手术治疗相结合的方法安全有效地控制 CRSwNP。
{"title":"Management of Nasal Polyposis in Pediatric Patients With Cornelia de Lange Syndrome: A Case Series and Literature Review.","authors":"Ian F Caplan, Michael Ye, Aaron N Pearlman","doi":"10.1177/01455613241284153","DOIUrl":"https://doi.org/10.1177/01455613241284153","url":null,"abstract":"<p><p>Cornelia de Lange syndrome (CdLS) is a rare genetic multiple malformation disorder with many otolaryngologic comorbidities. Patients with CdLS appear to have an increased prevalence of chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP), however, there is limited literature describing the presentation, evaluation, and management of CRSwNP within the CdLS population. Here we performed a literature review from Embase, PubMed, Cochrane Library, and Google Scholar and reported a case of CRSwNP with concomitant CdLS that was identified at our institution. We describe an 8-year-old male with CdLS and CRSwNP confirmed by history, physical exam, nasal endoscopy, and computed tomography. Symptoms of nasal obstruction were refractory to medical management and required repeat surgical management with improvement in nasal obstruction. Literature review identified 2 additional cases of nasal polyposis with similar management strategies. Additionally, one case series showed 33% of CdLS patients had recurrent sinusitis while a second series identified 39% of CdLS patients with CRS and 12% with CRSwNP. These data suggest that CRSwNP is more prevalent in patients with CdLS compared to the general public and can be both safely and effectively managed with a combination of medical and surgical therapy.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Strategies for Intra-Tonsillar Abscesses. 扁桃体内脓肿的治疗策略
Pub Date : 2024-09-24 DOI: 10.1177/01455613241286673
Changqing Wang, Suguang Sun, Huanhuan Xu, Changqing Zhao, Wenmin Zhao
{"title":"Treatment Strategies for Intra-Tonsillar Abscesses.","authors":"Changqing Wang, Suguang Sun, Huanhuan Xu, Changqing Zhao, Wenmin Zhao","doi":"10.1177/01455613241286673","DOIUrl":"https://doi.org/10.1177/01455613241286673","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perfusion Steroid via Ventilation Tube as Salvage Treatments for Sudden Sensorineural Hearing Loss. 通过通气管灌注类固醇作为突发性感音神经性听力损失的挽救性治疗。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241284154
Yang Mingbao, Zhang Bei, Guan Yafeng, Liang Xiuni, Miao Beiping

Objectives: Intratympanic steroid injection (ISI) for sudden sensorineural hearing loss (SSNHL) is a relatively popular and effective method, but there is no standardized method for intratympanic steroids for the treatment of SSNHL and no consensus on how to deliver steroids to the middle ear. The purpose of this study was to compare 2 means of intratympanic steroid delivery as therapy for SSNHL. Methods: A retrospective chart review was performed for the period from November 2018 to October 2022 at our Department of Otorhinolaryngology-Head and Neck Surgery. Sixty patients with profound SSNHL who have failed initial steroid therapy were divided into the continuously transtympanic steroid perfusion (TSP) therapy and the intermittent ISI therapy. Results: Posttreatment pure-tone average was 60.3 ± 18.2 dB in the TSP group and 67.5 ± 22.6 dB in the ISI group, 70.0% of subjects in the TSP group, and 46.7% of subjects in the ISI group had improved by 15 dB or more after the therapy. The increased hearing threshold of the TSP group (24.6 ± 14.1 dB) was better than the ISI group (16.6 ± 14.9 dB), and the hearing recovery was significantly different (P < .05) in the 2 groups. Besides the hearing improvement was most obvious in low-frequency areas in the TSP group, the most significant hearing improvement was at 250 Hz, reaching 30.8 ± 3.3 dB. Conclusions: In SSNHL patients who have failed initial steroid therapy, TSP therapy via a ventilation tube can achieve good hearing outcomes and serve as a salvage therapy for patients with SSNHL.

目的:鼓室内类固醇注射(ISI)治疗突发性感音神经性听力损失(SSNHL)是一种相对流行且有效的方法,但目前还没有治疗 SSNHL 的鼓室内类固醇标准方法,也没有就如何将类固醇输送到中耳达成共识。本研究的目的是比较治疗 SSNHL 的两种鼓室内类固醇给药方法。方法:本院耳鼻咽喉头颈外科对 2018 年 11 月至 2022 年 10 月期间的病历进行了回顾性分析。60例初始类固醇治疗失败的重度SSNHL患者被分为连续经鼓室类固醇灌注(TSP)疗法和间歇性ISI疗法。结果显示TSP组治疗后纯音平均值为(60.3 ± 18.2)分贝,ISI组为(67.5 ± 22.6)分贝,TSP组70.0%的受试者和ISI组46.7%的受试者在治疗后听力提高了15分贝或更多。TSP 组的听阈提高幅度(24.6 ± 14.1 dB)优于 ISI 组(16.6 ± 14.9 dB),两组的听力恢复情况有显著差异(P < .05)。此外,TSP 组的听力改善在低频区域最为明显,听力改善最显著的是 250 Hz,达到 30.8 ± 3.3 dB。结论对于初始类固醇治疗失败的 SSNHL 患者,通过通气管进行 TSP 治疗可获得良好的听力效果,可作为 SSNHL 患者的挽救疗法。
{"title":"Perfusion Steroid via Ventilation Tube as Salvage Treatments for Sudden Sensorineural Hearing Loss.","authors":"Yang Mingbao, Zhang Bei, Guan Yafeng, Liang Xiuni, Miao Beiping","doi":"10.1177/01455613241284154","DOIUrl":"https://doi.org/10.1177/01455613241284154","url":null,"abstract":"<p><p><b>Objectives:</b> Intratympanic steroid injection (ISI) for sudden sensorineural hearing loss (SSNHL) is a relatively popular and effective method, but there is no standardized method for intratympanic steroids for the treatment of SSNHL and no consensus on how to deliver steroids to the middle ear. The purpose of this study was to compare 2 means of intratympanic steroid delivery as therapy for SSNHL. <b>Methods:</b> A retrospective chart review was performed for the period from November 2018 to October 2022 at our Department of Otorhinolaryngology-Head and Neck Surgery. Sixty patients with profound SSNHL who have failed initial steroid therapy were divided into the continuously transtympanic steroid perfusion (TSP) therapy and the intermittent ISI therapy. <b>Results:</b> Posttreatment pure-tone average was 60.3 ± 18.2 dB in the TSP group and 67.5 ± 22.6 dB in the ISI group, 70.0% of subjects in the TSP group, and 46.7% of subjects in the ISI group had improved by 15 dB or more after the therapy. The increased hearing threshold of the TSP group (24.6 ± 14.1 dB) was better than the ISI group (16.6 ± 14.9 dB), and the hearing recovery was significantly different (<i>P</i> < .05) in the 2 groups. Besides the hearing improvement was most obvious in low-frequency areas in the TSP group, the most significant hearing improvement was at 250 Hz, reaching 30.8 ± 3.3 dB. <b>Conclusions:</b> In SSNHL patients who have failed initial steroid therapy, TSP therapy via a ventilation tube can achieve good hearing outcomes and serve as a salvage therapy for patients with SSNHL.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mandible-First and Maxilla-First Sequencing in Virtual Surgical Planning for Orthognathic Surgery: Comparison of Planned and Actual Outcomes. 正颌外科手术虚拟手术规划中的 "下颌先行 "和 "上颌先行 "排序:计划结果与实际结果的比较。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241280003
Ece Bozok, Abdullah Ozel, Emine Fulya Akkoyun, Elvan Dolanmaz

Background: Recent studies have shown that virtual planning for orthognathic surgery is an accurate and repeatable method. It is also a fact that surgical sequence can affect the results in terms of accuracy. Various studies stated that both approaches offer comparable results when properly planned and implemented; however, further clinical studies are still needed. This study aims to evaluate the effect of virtual surgical planning (VSP) on surgical outcomes and whether it is affected by mandible-first or maxilla-first approaches. Methods: This study analyzed data from 45 patients who underwent orthognathic surgery due to dentofacial deformity. Six of these patients underwent single-jaw orthognathic surgery, and 39 underwent bimaxillary orthognathic surgery (Maxilla-first group: 21, mandible-first group: 18). The displacements of specific landmarks were assessed by comparing preoperative and postoperative conventional computed tomographies with VSP data. Results: This study showed a statistically significant relationship between the measurements made with the 2 methods (r = .944; P = .0001). The fact that the intra-class correlation coefficient value is statistically significant and relatively high and that most of the differences in the Bland-Altman chart fall between the limits of compliance indicates a correlation between the virtual plan and surgical outcomes. In addition, in vertical measurements, the absolute mean difference of the B point and the Pogonion in the Maxilla-first group were statistically significantly higher than in the Mandible-first group (P = .038, P = .011). Conclusions: Our findings corroborate the high accuracy of the VSP reported in previous studies and also demonstrate that VSP with both maxilla-first and mandible-first sequencing achieves high accuracy in the sagittal and coronal planes. Although virtual planning significantly influences accurate surgical outcomes, it is not the sole determinant. Factors like condylar positioning and fixation methods can also impact the final results.

背景:最近的研究表明,虚拟规划正颌外科手术是一种准确且可重复的方法。事实上,手术顺序也会影响结果的准确性。多项研究表明,如果计划和实施得当,这两种方法的效果相当,但仍需进一步的临床研究。本研究旨在评估虚拟手术规划(VSP)对手术效果的影响,以及下颌先露法和上颌先露法对手术效果的影响。方法:本研究分析了 45 名因颌面部畸形而接受正颌手术的患者的数据。其中 6 名患者接受了单颌正颌手术,39 名患者接受了双颌正颌手术(上颌先行组:21 人,下颌先行组:18 人)。通过比较术前和术后的传统计算机断层扫描与 VSP 数据,评估了特定地标的位移情况。结果:研究表明,两种方法的测量结果之间存在显著的统计学关系(r = .944;P = .0001)。类内相关系数具有统计学意义且相对较高,布兰-阿尔特曼图中的大部分差异都在符合性界限之间,这表明虚拟计划与手术结果之间存在相关性。此外,在垂直测量中,上颌骨先行组的 B 点和 Pogonion 的绝对平均差在统计学上明显高于下颌骨先行组(P = .038, P = .011)。结论:我们的研究结果证实了之前研究中报道的 VSP 的高准确性,同时也证明了上颌骨先行和下颌骨先行排序的 VSP 在矢状面和冠状面上都能达到很高的准确性。虽然虚拟规划对准确的手术结果有很大影响,但它并不是唯一的决定因素。髁突定位和固定方法等因素也会影响最终结果。
{"title":"Mandible-First and Maxilla-First Sequencing in Virtual Surgical Planning for Orthognathic Surgery: Comparison of Planned and Actual Outcomes.","authors":"Ece Bozok, Abdullah Ozel, Emine Fulya Akkoyun, Elvan Dolanmaz","doi":"10.1177/01455613241280003","DOIUrl":"https://doi.org/10.1177/01455613241280003","url":null,"abstract":"<p><p><b>Background:</b> Recent studies have shown that virtual planning for orthognathic surgery is an accurate and repeatable method. It is also a fact that surgical sequence can affect the results in terms of accuracy. Various studies stated that both approaches offer comparable results when properly planned and implemented; however, further clinical studies are still needed. This study aims to evaluate the effect of virtual surgical planning (VSP) on surgical outcomes and whether it is affected by mandible-first or maxilla-first approaches. <b>Methods:</b> This study analyzed data from 45 patients who underwent orthognathic surgery due to dentofacial deformity. Six of these patients underwent single-jaw orthognathic surgery, and 39 underwent bimaxillary orthognathic surgery (Maxilla-first group: 21, mandible-first group: 18). The displacements of specific landmarks were assessed by comparing preoperative and postoperative conventional computed tomographies with VSP data. <b>Results:</b> This study showed a statistically significant relationship between the measurements made with the 2 methods (<i>r</i> = .944; <i>P</i> = .0001). The fact that the intra-class correlation coefficient value is statistically significant and relatively high and that most of the differences in the Bland-Altman chart fall between the limits of compliance indicates a correlation between the virtual plan and surgical outcomes. In addition, in vertical measurements, the absolute mean difference of the B point and the Pogonion in the Maxilla-first group were statistically significantly higher than in the Mandible-first group (<i>P</i> = .038, <i>P</i> = .011). <b>Conclusions:</b> Our findings corroborate the high accuracy of the VSP reported in previous studies and also demonstrate that VSP with both maxilla-first and mandible-first sequencing achieves high accuracy in the sagittal and coronal planes. Although virtual planning significantly influences accurate surgical outcomes, it is not the sole determinant. Factors like condylar positioning and fixation methods can also impact the final results.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Throat Edema Unresponsive to Glucocorticoids and Antihistamines: A Warning for the Risk of Hereditary Angioedema. 对糖皮质激素和抗组胺药无反应的喉头水肿:遗传性血管性水肿风险警告。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241284900
Yali Liu, Fen Chen, Guowei Ma, Yuanyuan Wu
{"title":"Throat Edema Unresponsive to Glucocorticoids and Antihistamines: A Warning for the Risk of Hereditary Angioedema.","authors":"Yali Liu, Fen Chen, Guowei Ma, Yuanyuan Wu","doi":"10.1177/01455613241284900","DOIUrl":"https://doi.org/10.1177/01455613241284900","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Preoperative Flexible Fiberoptic Laryngoscopy on Anesthesia's Intubation Plans. 术前柔性纤维喉镜检查对麻醉科插管计划的影响。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241275485
Anna Celeste Gibson, Soroush Farsi, Kyle Davis, Deanne King, Mauricio Moreno, Jumin Sunde, Emre A Vural

Purpose: To assess the value of conducting a preairway management review of flexible fiberoptic laryngoscopy examinations (FFL) by the anesthesia team for patients with head and neck cancer and to examine its impact on intubation strategies and overall patient safety. Methods: Prospective study at a single tertiary referral center including patients with stage T2 and greater cancers of the oropharynx, hypopharynx, or larynx who underwent intubation by the anesthesia team between May 2022 and April 2023. Pre- and postoperative surveys gathered data on the intubation plan, including details such as method, sedation, patient respiration, laryngoscope, tube size, and use of paralysis. Postoperative surveys gauged the FFL's subjective utility and documented intubation details and complications. Results: Thirty-four patients (49-87 years of age) were included in the study. Eleven intubation plans were changed after reviewing the FFL, while 23 were not. Although this was a pilot study, there was no significant correlation between location of the tumor and change in intubation plan. Of the 34 intubations, 9 were executed based on the plan after reviewing FFL. The majority of the attending anesthesiologists agreed or strongly agreed that seeing the FFL was more helpful than reading the findings in clinic notes and that reviewing the FFL was helpful in creating the intubation plan, 77% and 88%, respectively. Conclusion: Reviewing the FFL led to changes in the anesthesia team's intubation plan in 32% of the cases in our pilot study. While these findings are promising, they highlight the need for further research with larger sample sizes and across multiple centers to validate the impact of FFL on intubation strategies for patients with stage T2 and greater cancers of the oropharynx, hypopharynx, or larynx.

目的: 评估麻醉团队对头颈部癌症患者进行柔性纤维喉镜检查 (FFL) 的气道管理前审查的价值,并研究其对插管策略和整体患者安全的影响。研究方法在一家三级转诊中心进行的前瞻性研究,包括在2022年5月至2023年4月期间接受麻醉团队插管的口咽、下咽或喉部T2期及以上癌症患者。术前和术后调查收集了有关插管计划的数据,包括插管方法、镇静剂、患者呼吸、喉镜、插管尺寸和麻痹的使用等细节。术后调查衡量了 FFL 的主观实用性,并记录了插管细节和并发症。结果:研究共纳入 34 名患者(49-87 岁)。有 11 名患者在查看 FFL 后改变了插管计划,23 名患者没有改变。虽然这是一项试验性研究,但肿瘤位置与插管计划的改变之间没有明显的相关性。在 34 次插管中,有 9 次是在查看 FFL 后根据计划执行的。大多数主治麻醉师同意或非常同意看到 FFL 比阅读门诊笔记中的结果更有帮助,以及审阅 FFL 有助于制定插管计划,分别占 77% 和 88%。结论:在我们的试点研究中,有 32% 的病例通过查看 FFL 更改了麻醉团队的插管计划。虽然这些发现很有希望,但它们强调了进一步研究的必要性,即在多个中心进行更大样本量的研究,以验证 FFL 对口咽癌、下咽癌或喉癌 T2 期及以上患者插管策略的影响。
{"title":"The Impact of Preoperative Flexible Fiberoptic Laryngoscopy on Anesthesia's Intubation Plans.","authors":"Anna Celeste Gibson, Soroush Farsi, Kyle Davis, Deanne King, Mauricio Moreno, Jumin Sunde, Emre A Vural","doi":"10.1177/01455613241275485","DOIUrl":"https://doi.org/10.1177/01455613241275485","url":null,"abstract":"<p><p><b>Purpose:</b> To assess the value of conducting a preairway management review of flexible fiberoptic laryngoscopy examinations (FFL) by the anesthesia team for patients with head and neck cancer and to examine its impact on intubation strategies and overall patient safety. <b>Methods:</b> Prospective study at a single tertiary referral center including patients with stage T2 and greater cancers of the oropharynx, hypopharynx, or larynx who underwent intubation by the anesthesia team between May 2022 and April 2023. Pre- and postoperative surveys gathered data on the intubation plan, including details such as method, sedation, patient respiration, laryngoscope, tube size, and use of paralysis. Postoperative surveys gauged the FFL's subjective utility and documented intubation details and complications. <b>Results:</b> Thirty-four patients (49-87 years of age) were included in the study. Eleven intubation plans were changed after reviewing the FFL, while 23 were not. Although this was a pilot study, there was no significant correlation between location of the tumor and change in intubation plan. Of the 34 intubations, 9 were executed based on the plan after reviewing FFL. The majority of the attending anesthesiologists agreed or strongly agreed that seeing the FFL was more helpful than reading the findings in clinic notes and that reviewing the FFL was helpful in creating the intubation plan, 77% and 88%, respectively. <b>Conclusion:</b> Reviewing the FFL led to changes in the anesthesia team's intubation plan in 32% of the cases in our pilot study. While these findings are promising, they highlight the need for further research with larger sample sizes and across multiple centers to validate the impact of FFL on intubation strategies for patients with stage T2 and greater cancers of the oropharynx, hypopharynx, or larynx.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Middle Ear Cholesteatoma: A Report of 3 Cases and a Literature Review. 先天性中耳胆脂瘤:3 个病例的报告和文献综述。
Pub Date : 2024-09-24 DOI: 10.1177/01455613241283799
Li Xie, Lingling Zeng

Background: Congenital cholesteatoma is defined as a white mass behind an intact eardrum without a history of otitis media or previous otologic procedures. Congenital cholesteatoma is a relatively rare disease that accounts for about 2% to 5% of all cholesteatomas. However, the actual incidence rate of congenital cholesteatoma may be underestimated. Conductive hearing loss is the most common presenting symptom. The current study aims to describe the clinical characteristics and management of patients with congenital cholesteatoma and promote awareness of the disease in unilateral or asymmetric conductive hearing loss patients. Methods: In this study, we report a case series of 3 patients including 1 child, 1 adolescent, and 1 young adult, managed in our department between June and August 2023, and present a summary of the literature. Results: Congenital cholesteatoma is primarily a pediatric disease, but it has also been reported in adults. Two cases presented with unilateral secretory otitis media, and 1 case presented with asymmetric unilateral conductive hearing loss. Two patients of Potsic stage III congenital middle ear cholesteatomas underwent transcanal endoscopic ear surgery, and 1 patient of Potsic stage IV underwent conventional microscopic approach canal wall-up mastoidectomy combined with endoscopy. Conclusions: In children or young adults with persistent unilateral or asymmetric conductive hearing loss, congenital middle ear cholesteatoma should be considered. Congenital cholesteatoma cannot be ruled out in children with unilateral secretory otitis media.

背景:先天性胆脂瘤是指完整鼓膜后的白色肿块,没有中耳炎或耳科手术史。先天性胆脂瘤是一种相对罕见的疾病,约占所有胆脂瘤的 2% 至 5%。不过,先天性胆脂瘤的实际发病率可能被低估了。传导性听力损失是最常见的症状。本研究旨在描述先天性胆脂瘤患者的临床特征和处理方法,提高单侧或不对称传导性听力损失患者对该疾病的认识。方法:本研究报告了我科在 2023 年 6 月至 8 月期间收治的 3 例系列病例,包括 1 名儿童、1 名青少年和 1 名年轻成人,并对文献进行了总结。研究结果先天性胆脂瘤主要是一种儿童疾病,但也有成人患病的报道。2例患者伴有单侧分泌性中耳炎,1例患者伴有非对称性单侧传导性听力损失。两例 Potsic III 期先天性中耳胆脂瘤患者接受了经耳道内窥镜耳科手术,一例 Potsic IV 期患者接受了常规显微镜下耳道壁上乳突切除术联合内窥镜手术。结论对于患有持续性单侧或不对称传导性听力损失的儿童或青少年,应考虑先天性中耳胆脂瘤。单侧分泌性中耳炎患儿不能排除先天性胆脂瘤。
{"title":"Congenital Middle Ear Cholesteatoma: A Report of 3 Cases and a Literature Review.","authors":"Li Xie, Lingling Zeng","doi":"10.1177/01455613241283799","DOIUrl":"https://doi.org/10.1177/01455613241283799","url":null,"abstract":"<p><p><b>Background:</b> Congenital cholesteatoma is defined as a white mass behind an intact eardrum without a history of otitis media or previous otologic procedures. Congenital cholesteatoma is a relatively rare disease that accounts for about 2% to 5% of all cholesteatomas. However, the actual incidence rate of congenital cholesteatoma may be underestimated. Conductive hearing loss is the most common presenting symptom. The current study aims to describe the clinical characteristics and management of patients with congenital cholesteatoma and promote awareness of the disease in unilateral or asymmetric conductive hearing loss patients. <b>Methods:</b> In this study, we report a case series of 3 patients including 1 child, 1 adolescent, and 1 young adult, managed in our department between June and August 2023, and present a summary of the literature. <b>Results:</b> Congenital cholesteatoma is primarily a pediatric disease, but it has also been reported in adults. Two cases presented with unilateral secretory otitis media, and 1 case presented with asymmetric unilateral conductive hearing loss. Two patients of Potsic stage III congenital middle ear cholesteatomas underwent transcanal endoscopic ear surgery, and 1 patient of Potsic stage IV underwent conventional microscopic approach canal wall-up mastoidectomy combined with endoscopy. <b>Conclusions:</b> In children or young adults with persistent unilateral or asymmetric conductive hearing loss, congenital middle ear cholesteatoma should be considered. Congenital cholesteatoma cannot be ruled out in children with unilateral secretory otitis media.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intralabyrinthine Cholesterol Granuloma. 迷走神经管内胆固醇肉芽肿
Pub Date : 2024-09-23 DOI: 10.1177/01455613241271711
Dae-Yang Kim, Eun-Ju Jeon, Hyun Jin Lee

Cholesterol granulomas are typically identified by their histological features, including cholesterol crystals, giant cells, fibrosis, and inflammation. They occur predominantly in the middle ear, petrous apex, and orbital region, with rare occurrences in the labyrinth. Diagnosis of these lesions is challenging due to their imaging similarities with endolymphatic sac tumors, particularly in preoperative differentiation. In the present case, a 60-year-old woman diagnosed with an endolymphatic sac tumor through preoperative magnetic resonance imaging underwent a transmastoid surgical procedure, and subsequent postoperative histopathological analysis confirmed a cholesterol granuloma. We report this rare case of granuloma confined within the labyrinth, highlighting the importance of radiological and histopathological diagnoses in determining the appropriate therapeutic approach.

胆固醇肉芽肿通常根据其组织学特征(包括胆固醇结晶、巨细胞、纤维化和炎症)来鉴别。胆固醇肉芽肿主要发生在中耳、瓣顶和眼眶区域,极少发生在迷宫。由于这些病变的影像学表现与内淋巴囊肿瘤相似,因此诊断具有挑战性,尤其是在术前鉴别时。在本病例中,一名 60 岁的女性通过术前磁共振成像被诊断为内淋巴囊肿瘤,接受了经乳突手术治疗,术后组织病理分析证实为胆固醇肉芽肿。我们报告了这例罕见的局限于迷宫内的肉芽肿病例,强调了放射学和组织病理学诊断在确定适当治疗方法方面的重要性。
{"title":"Intralabyrinthine Cholesterol Granuloma.","authors":"Dae-Yang Kim, Eun-Ju Jeon, Hyun Jin Lee","doi":"10.1177/01455613241271711","DOIUrl":"https://doi.org/10.1177/01455613241271711","url":null,"abstract":"<p><p>Cholesterol granulomas are typically identified by their histological features, including cholesterol crystals, giant cells, fibrosis, and inflammation. They occur predominantly in the middle ear, petrous apex, and orbital region, with rare occurrences in the labyrinth. Diagnosis of these lesions is challenging due to their imaging similarities with endolymphatic sac tumors, particularly in preoperative differentiation. In the present case, a 60-year-old woman diagnosed with an endolymphatic sac tumor through preoperative magnetic resonance imaging underwent a transmastoid surgical procedure, and subsequent postoperative histopathological analysis confirmed a cholesterol granuloma. We report this rare case of granuloma confined within the labyrinth, highlighting the importance of radiological and histopathological diagnoses in determining the appropriate therapeutic approach.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory Study of Relationship Between Obstructive Sleep Apnea Syndrome and Growth Hormones and Inflammatory Factors in Children. 儿童阻塞性睡眠呼吸暂停综合征与生长激素和炎症因子关系的探索性研究
Pub Date : 2024-09-23 DOI: 10.1177/01455613241272474
Junlong Tan, Jie Zhang, Kunpeng Li, Yunxiao Wu, Li Zheng, Zhifei Xu, Xin Ni

Purpose: In children, obstructive sleep apnea (OSA) is associated with growth hormone level abnormalities and chronic systemic inflammation. This study was performed to investigate the relationship of the degree of OSA with insulin-like growth factor 1 (IGF-1) and inflammatory cytokines in pediatric OSA and the inter-relationship between inflammatory cytokines and growth hormones. Methods: Children with OSA and controls without OSA participated in the study. Information included polysomnography followed by measurement of IGF-1 and inflammatory marker levels. In total, 226 patients aged 2 to 12 years were divided into 4 groups: non-OSA, n = 57 (25.2%); mild OSA, n = 116 (51.3%); moderate OSA, n = 23 (10.2%); and severe OSA, n = 30 (13.3%). Results: Body height was not significantly different among the 4 groups. However, the minimum oxygen saturation and IGF-1 significantly differed among the different OSA groups (P = .0001 and P = .036, respectively). IGF-1 was significantly higher in the non-OSA group (P < .05) and mild OSA group (P < .01) than in the severe OSA group. As the severity of OSA increased, the interleukin-5 level significantly increased, which caused a difference between mild OSA and moderate OSA (P < .05) and between mild OSA and severe OSA (P < .001). In the univariate quantile regression analysis of IGF-1, there was a negative relationship between IGF-1 and IL-5 (P < .001). IGF-1 was positively correlated with age, height, and minimum oxygen saturation. Furthermore, there was a negative correlation between the IGF-1 level and the severity of OSA. Quantile regression analysis on the multivariable analysis of the IGF-1 association showed that height, sex, and severity of OSA played important roles in affecting IGF-1 levels. Conclusion: High IL-5 levels may lead to the low secretion of growth hormone level (IGF-1) in children, thus affecting growth and development.

目的:在儿童中,阻塞性睡眠呼吸暂停(OSA)与生长激素水平异常和慢性全身性炎症有关。本研究旨在探讨小儿 OSA 的 OSA 程度与胰岛素样生长因子 1(IGF-1)和炎症细胞因子的关系,以及炎症细胞因子和生长激素之间的相互关系。方法:患有 OSA 的儿童和未患有 OSA 的对照组儿童参与研究。信息包括多导睡眠图,然后测量 IGF-1 和炎症标志物水平。总共 226 名 2 至 12 岁的患者被分为 4 组:非 OSA,57 人(25.2%);轻度 OSA,116 人(51.3%);中度 OSA,23 人(10.2%);重度 OSA,30 人(13.3%)。结果四组患者的身高无明显差异。然而,最低血氧饱和度和 IGF-1 在不同 OSA 组间存在显著差异(分别为 P = .0001 和 P = .036)。非 OSA 组(P < .05)和轻度 OSA 组(P < .01)的 IGF-1 明显高于重度 OSA 组。随着OSA严重程度的增加,白细胞介素-5水平也明显升高,这导致了轻度OSA与中度OSA之间的差异(P < .05)以及轻度OSA与重度OSA之间的差异(P < .001)。在IGF-1的单变量量化回归分析中,IGF-1与IL-5呈负相关(P < .001)。IGF-1 与年龄、身高和最低血氧饱和度呈正相关。此外,IGF-1 水平与 OSA 的严重程度呈负相关。对 IGF-1 相关性的多变量回归分析表明,身高、性别和 OSA 的严重程度在影响 IGF-1 水平方面起着重要作用。结论高IL-5水平可能导致儿童生长激素(IGF-1)分泌水平低,从而影响生长发育。
{"title":"Exploratory Study of Relationship Between Obstructive Sleep Apnea Syndrome and Growth Hormones and Inflammatory Factors in Children.","authors":"Junlong Tan, Jie Zhang, Kunpeng Li, Yunxiao Wu, Li Zheng, Zhifei Xu, Xin Ni","doi":"10.1177/01455613241272474","DOIUrl":"https://doi.org/10.1177/01455613241272474","url":null,"abstract":"<p><p><b>Purpose:</b> In children, obstructive sleep apnea (OSA) is associated with growth hormone level abnormalities and chronic systemic inflammation. This study was performed to investigate the relationship of the degree of OSA with insulin-like growth factor 1 (IGF-1) and inflammatory cytokines in pediatric OSA and the inter-relationship between inflammatory cytokines and growth hormones. <b>Methods:</b> Children with OSA and controls without OSA participated in the study. Information included polysomnography followed by measurement of IGF-1 and inflammatory marker levels. In total, 226 patients aged 2 to 12 years were divided into 4 groups: non-OSA, n = 57 (25.2%); mild OSA, n = 116 (51.3%); moderate OSA, n = 23 (10.2%); and severe OSA, n = 30 (13.3%). <b>Results:</b> Body height was not significantly different among the 4 groups. However, the minimum oxygen saturation and IGF-1 significantly differed among the different OSA groups (<i>P</i> = .0001 and <i>P</i> = .036, respectively). IGF-1 was significantly higher in the non-OSA group (<i>P</i> < .05) and mild OSA group (<i>P</i> < .01) than in the severe OSA group. As the severity of OSA increased, the interleukin-5 level significantly increased, which caused a difference between mild OSA and moderate OSA (<i>P</i> < .05) and between mild OSA and severe OSA (<i>P</i> < .001). In the univariate quantile regression analysis of IGF-1, there was a negative relationship between IGF-1 and IL-5 (<i>P</i> < .001). IGF-1 was positively correlated with age, height, and minimum oxygen saturation. Furthermore, there was a negative correlation between the IGF-1 level and the severity of OSA. Quantile regression analysis on the multivariable analysis of the IGF-1 association showed that height, sex, and severity of OSA played important roles in affecting IGF-1 levels. <b>Conclusion:</b> High IL-5 levels may lead to the low secretion of growth hormone level (IGF-1) in children, thus affecting growth and development.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Ear, nose, & throat journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1