Experimental gerontology最新文献_第5页

Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET 通过可溶性RAGE揭示营养不良：来自FRASNET的生物标志物引导的见解。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-10 DOI: 10.1016/j.exger.2026.113032

Sarah Damanti , Clara Sciorati , Amanda Avola , Rebecca De Lorenzo , Maria Pia Ruggiero , Simona Santoro , Eleonora Senini , Marco Messina , Francesca Farina , Costanza Festorazzi , Giulia Pata , Martina Laffranchi , Martina Mallus , Elena Brioni , Lorena Citterio , Laura Zagato , Marco Simonini , Chiara Lanzani , Paolo Manunta , Angelo Manfredi , Patrizia Rovere-Querini

Background

Malnutrition is a prevalent geriatric syndrome, with multifactorial etiology and consequences for health and independence. Inflammation contributes to nutritional decline, yet conventional inflammatory markers often lack sensitivity for identifying malnutrition risk. The soluble receptor for advanced glycation end-products (sRAGE), a modulator of inflammatory responses, has emerged as a biomarker of disease risk and adverse outcomes in various conditions.

Objectives

to evaluate the association between circulating sRAGE levels and nutritional status in community-dwelling older adults.

Methods

This prospective observational study was conducted within the FRASNET cohort. Fifty-two community-dwelling older adults underwent multidimensional geriatric assessments during two time periods: 2017–2020 and 2023–2024. Serum sRAGE levels were measured at both timepoints. Nutritional status was assessed using the Mini Nutritional Assessment Short Form (MNA-SF). Associations between sRAGE and clinical parameters were evaluated through linear regression models adjusted for age and sex. The diagnostic performance of sRAGE in identifying malnutrition was assessed using ROC curve analysis.

Results

Higher baseline sRAGE levels were significantly associated with lower BMI (β = −0.003, p = 0.036), reduced calf circumference (β = −0.002, p = 0.04), and poorer nutritional status as revealed by MNA-SF scores (β = −0.001, p = 0.03) at follow-up. Associations were more pronounced in women. ROC analysis indicated good diagnostic accuracy for identifying malnutrition risk, with an AUC of 0.85. The optimal sRAGE cut-off value for malnutrition risk was 1362.5 pg/ml.

Conclusions

Higher sRAGE levels were prospectively associated with poorer nutritional outcomes in older adults, particularly in women. sRAGE may aid early identification of inflammation-related malnutrition risk.

背景：营养不良是一种普遍的老年综合征，具有多因素的病因和对健康和独立的影响。炎症有助于营养下降，但传统的炎症标志物往往缺乏识别营养不良风险的敏感性。晚期糖基化终产物可溶性受体（sRAGE）是炎症反应的调节剂，已成为各种疾病风险和不良后果的生物标志物。目的：评估社区居住老年人循环sRAGE水平与营养状况之间的关系。方法：这项前瞻性观察性研究在FRASNET队列中进行。在2017-2020年和2023-2024年两个时间段内，52名社区居住的老年人接受了多维老年病学评估。在两个时间点测量血清sRAGE水平。采用迷你营养评估简表（MNA-SF）评估营养状况。通过调整年龄和性别的线性回归模型评估sRAGE与临床参数之间的关系。采用ROC曲线分析评价sRAGE对营养不良的诊断效果。结果:高基线sRAGE水平显著降低BMI(β = -0.003,p = 0.036),降低小腿周长(β = -0.002,p = 0.04),和贫穷的营养状况揭示了MNA-SF分数(β = -0.001,p = 0.03)在随访。这种关联在女性中更为明显。ROC分析显示，鉴别营养不良风险的诊断准确性良好，AUC为0.85。营养不良风险的最佳sRAGE临界值为1362.5 pg/mL。结论：较高的sRAGE水平与老年人（尤其是女性）较差的营养结局相关。sRAGE可能有助于早期识别炎症相关的营养不良风险。

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引用次数: 0

Irisin and the muscle–brain axis: Mechanisms and translational potential 鸢尾素和肌肉-脑轴：机制和转化潜力

IF 4.3

Experimental gerontology

Pub Date : 2026-01-09 DOI: 10.1016/j.exger.2026.113028

Beatrice Arosio , Anna Picca

The muscle–brain axis integrates peripheral metabolic activity with central nervous system function. Among the endocrine signaling molecules regulating such crosstalk, the peptide hormone irisin released during muscle contraction seems to play relevant roles. Irisin is generated by the proteolytic cleavage of the fibronectin type III domain-containing protein 5 and has emerged as a key regulator of neurotrophic and metabolic adaptation. Although initially described as a myokine, irisin is also expressed in adipose and neural tissues, acting through autocrine, paracrine, and endocrine mechanisms. Irisin binds to the αV/β5 integrin receptor complex and activates a network of signaling pathways which promote mitochondrial biogenesis, autophagy, oxidative stress resistance, and modulation of inflammatory responses. Within the central nervous system, irisin induces brain-derived neurotrophic factor expression and contributes to synaptic plasticity, neurogenesis, and cognitive preservation. Experimental models show that irisin reduces amyloid burden, limits α-synuclein pathology, suppresses neuroinflammation, and stabilizes blood–brain barrier integrity, supporting a disease-modifying role in neurodegenerative conditions. In skeletal muscle, irisin stimulates myogenesis, enhances anabolic signaling, and improves metabolic efficiency, suggesting broader relevance for sarcopenia and age-related metabolic decline. Herein, we discuss irisin as a promising biomarker and a candidate therapeutic target for disorders characterized by concurrent muscle deterioration and cognitive impairment.

肌脑轴整合了外周代谢活动和中枢神经系统功能。在调节这种串扰的内分泌信号分子中，肌肉收缩时释放的肽激素鸢尾素似乎起着相关的作用。鸢尾素是由含有纤维连接蛋白III型结构域的蛋白5的蛋白水解裂解产生的，并已成为神经营养和代谢适应的关键调节剂。虽然最初被描述为一种肌肉因子，但鸢尾素也在脂肪和神经组织中表达，通过自分泌、旁分泌和内分泌机制起作用。鸢尾素与αV/β5整合素受体复合物结合，激活一系列信号通路，促进线粒体生物发生、自噬、氧化应激抵抗和炎症反应调节。在中枢神经系统中，鸢尾素诱导脑源性神经营养因子表达，有助于突触可塑性、神经发生和认知保存。实验模型表明，鸢尾素可减轻淀粉样蛋白负担，限制α-突触核蛋白病理，抑制神经炎症，稳定血脑屏障完整性，支持在神经退行性疾病中的疾病调节作用。在骨骼肌中，鸢尾素刺激肌肉生成，增强合成代谢信号，提高代谢效率，这表明鸢尾素与肌肉减少症和年龄相关的代谢下降有广泛的相关性。在此，我们讨论鸢尾素作为一种有前景的生物标志物和以并发肌肉退化和认知障碍为特征的疾病的候选治疗靶点。

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引用次数: 0

D-Galactose induces the senescence and senescence-related secretory phenotype switch of nucleus pulposus cells d -半乳糖诱导髓核细胞衰老及与衰老相关的分泌表型转换。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-08 DOI: 10.1016/j.exger.2026.113025

ShuWen Zhang , Jing Du , Dilimulati Aikeremu , ZhanBin Ma , Hao Wang

Senescence of nucleus pulposus cells (NPCs) in degenerative intervertebral discs is related to the development and progression of intervertebral disc degeneration (IVDD). The aim of this study was to establish a reliable and robust cell senescent model using D-galactose (D-Gal) to induce oxidative stress in NPCs. NPCs were isolated from Sprague Dawley rats and incubated with increasing concentrations of D-Gal. Cell viability, cell cycle, senescence-associated markers, and extracellular matrix were detected to evaluate the effect of D-Gal on NPCs. The migration and polarization of macrophage were observed by Transwell assay and flow cytometry. Finally, the oxidative stress mechanism of D-Gal induced NPCs senescence was analyzed by flow cytometry and absorbance analysis. Cell viability and cell cycle analyses revealed that D-Gal induced senescence by blocking DNA synthesis and decreasing NPC proliferation. Furthermore, a dose-dependent increase was observed in senescence-associated makers in D-Gal induced NPCs. RT-qPCR analysis revealed an increase in mRNA expression of key senescence related secretory phenotype (SASP) components. Extracellular matrix was significantly decreased along with cell senescence. Transwell assay and flow cytometry revealed that senescent NPC-conditioned medium triggered macrophage migration and polarization. Increased levels of reactive oxygen species (ROS), advanced glycation end products, and the lipid peroxidation product malondialdehyde, along with decreased superoxide dismutase activity, were associated with the senescence of NPCs induced by D-Gal. The data imply that D-Gal treatment successfully triggered senescence in NPCs and SASP switch, establishing it as a reliable model for studying IVDD.

退行性椎间盘髓核细胞（NPCs）的衰老与椎间盘退变（IVDD）的发生和进展有关。本研究的目的是利用d -半乳糖（D-Gal）诱导npc氧化应激，建立一个可靠且稳健的细胞衰老模型。从Sprague Dawley大鼠中分离npc，用浓度增加的D-Gal孵育。通过检测细胞活力、细胞周期、衰老相关maker和细胞外基质来评估D-Gal对npc的影响。采用Transwell实验和流式细胞术观察巨噬细胞的迁移和极化情况。最后，通过流式细胞术和吸光度分析分析D-Gal氧化应激诱导NPCs衰老的机制。细胞活力和细胞周期分析表明，D-Gal通过阻断DNA合成和降低鼻咽癌细胞增殖诱导衰老。此外，在D-Gal诱导的NPCs中，观察到衰老相关制造商的剂量依赖性增加。RT-qPCR分析显示，关键衰老相关分泌表型（SASP）成分的mRNA表达增加。随着细胞衰老，细胞外基质明显减少。Transwell实验和流式细胞术显示，衰老的npc条件培养基引发巨噬细胞迁移和极化。活性氧（ROS）、晚期糖基化终产物和脂质过氧化产物丙二醛水平的增加，以及超氧化物歧化酶活性的降低，与D-Gal诱导的npc衰老有关。数据表明，D-Gal处理成功触发了NPCs的衰老和SASP开关，为研究IVDD建立了可靠的模型。

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引用次数: 0

Quercetin rejuvenates aged adipose progenitor cells by attenuating inflammatory pathways 槲皮素通过减轻炎症途径使衰老的脂肪祖细胞恢复活力。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-08 DOI: 10.1016/j.exger.2026.113027

Junwan Fan , Ling Zhou , Run Song , Fuqiang Yang , Yingjie Geng , Xueyu Zhang , Qiuhua Yu , Zirui Li , Yan Wang , Wenyan He

The mass of inguinal white adipose tissue (iWAT) decreases with age, and its dysfunction contributes to systemic effects, including chronic inflammation, ectopic lipid deposition, and insulin resistance. However, the molecular and functional characteristics of aged adipose progenitor cells (APCs), as well as effective strategies to rejuvenate their adipogenic potential, remain poorly understood. In this study, we found that aged mice exhibited a reduced frequency of APCs, increased inflammatory activity, and impaired adipogenic differentiation capacity. Strikingly, while quercetin exerted concentration-dependent effects on the vitality and function of APCs, only moderate doses specifically restored the adipogenic differentiation of aged APCs. Mechanistically, this rejuvenating effect was primarily mediated through the suppression of pro-inflammatory pathways. Together, our findings provide novel mechanistic insights into APCs aging in iWAT and identify quercetin as a promising rejuvenative agent for the treatment of adipose tissue dysfunction and related metabolic disorders in aging.

腹股沟白色脂肪组织（iWAT）随着年龄的增长而减少，其功能障碍导致全身影响，包括慢性炎症、异位脂质沉积和胰岛素抵抗。然而，衰老脂肪祖细胞（APCs）的分子和功能特征，以及恢复其脂肪生成潜力的有效策略，仍然知之甚少。在这项研究中，我们发现老年小鼠表现出apc频率降低，炎症活性增加，脂肪生成分化能力受损。引人注目的是，虽然槲皮素对apc的活力和功能具有浓度依赖性，但只有中等剂量才能特异性地恢复衰老apc的成脂分化。从机制上讲，这种恢复活力的效果主要是通过抑制促炎途径介导的。总之，我们的研究结果为iWAT中APCs的衰老提供了新的机制见解，并确定槲皮素是治疗衰老中脂肪组织功能障碍和相关代谢紊乱的有希望的恢复剂。

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引用次数: 0

Intrinsic capacity–frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study 社区居住的八旬老人的内在能力脆弱表型和亚临床炎症：来自ilSIRENTE研究的横断面分析

IF 4.3

Experimental gerontology

Pub Date : 2026-01-06 DOI: 10.1016/j.exger.2026.113026

Stefano Cacciatore , Riccardo Calvani , Konstantinos Prokopidis , Mathias Schlögl , Andrea Russo , Matteo Tosato , Stephen D. Anton , Christiaan Leeuwenburgh , John A. Batsis , Emanuele Marzetti , Francesco Landi

Background

Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC–frailty phenotypes and systemic inflammation in community-dwelling octogenarians and identify IC domains most closely related to inflammatory burden.

Methods

IC was assessed across five domains (locomotion, cognition, vitality, psychological well-being, and sensory function), rescaled to a 0–100 range, and combined with frailty status to define four IC–frailty phenotypes (concordant frail, discordant low IC, discordant high IC, concordant robust). Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured, and a composite inflammatory burden score (0–3) was derived.

Results

The analysis included 311 participants (mean age 85.4 ± 4.7 years, 66.6 % women). Median CRP, IL-6, and TNF-α levels increased progressively from concordant robust to concordant frail groups (p < 0.01). In the fully adjusted model, concordant frail participants had higher inflammation compared with concordant robust (β = 0.71; 95 % CI 0.04–1.37; p = 0.03), while discordant high IC and discordant low IC showed intermediate values without statistical significance. A significant linear trend was observed across ordered phenotypes (β per category increment = 0.21, 95 % CI 0.06 to 0.37). Locomotion and vitality emerged as the domains most strongly linked to inflammation.

Conclusions

IC–frailty phenotypes show a biological gradient of subclinical inflammation, with higher IC having lower inflammation levels. Preserved locomotion reflects key functional correlates of resilience and vitality in advanced age.

背景：慢性低度炎症会导致衰老过程中的身体虚弱和功能下降。内在能力（Intrinsic capacity， IC）被定义为身体和心理储备的综合体，通过反映功能弹性来补充脆弱性评估。本横断面分析使用来自ilSIRENTE队列的基线数据来检查社区居住的80岁老人IC脆弱表型与全身性炎症之间的关系，并确定与炎症负担最密切相关的IC结构域。方法通过五个领域（运动、认知、活力、心理健康和感觉功能）评估sic，重新调整到0-100的范围，并结合虚弱状态定义四种IC脆弱表型（和谐体弱、不和谐低IC、不和谐高IC、和谐健壮）。检测血浆c反应蛋白（CRP）、白细胞介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)，得出炎症负荷综合评分（0-3）。结果共纳入311例患者（平均年龄85.4±4.7岁，66.6%为女性）。中位CRP、IL-6和TNF-α水平从健康组到虚弱组逐渐升高（p < 0.01）。在完全调整后的模型中，一致性虚弱的受试者比一致性健壮的受试者有更高的炎症（β = 0.71; 95% CI 0.04-1.37; p = 0.03），而不一致性高IC和不一致性低IC显示中间值，无统计学意义。在有序表型之间观察到显著的线性趋势（每类别增量β = 0.21, 95% CI 0.06至0.37）。运动和活力是与炎症最密切相关的领域。结论IC脆弱表型具有亚临床炎症的生物学梯度，IC高，炎症水平低。保持运动反映了老年人的弹性和活力的关键功能相关。

{"title":"Intrinsic capacity–frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study","authors":"Stefano Cacciatore , Riccardo Calvani , Konstantinos Prokopidis , Mathias Schlögl , Andrea Russo , Matteo Tosato , Stephen D. Anton , Christiaan Leeuwenburgh , John A. Batsis , Emanuele Marzetti , Francesco Landi","doi":"10.1016/j.exger.2026.113026","DOIUrl":"10.1016/j.exger.2026.113026","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC–frailty phenotypes and systemic inflammation in community-dwelling octogenarians and identify IC domains most closely related to inflammatory burden.</div></div><div><h3>Methods</h3><div>IC was assessed across five domains (locomotion, cognition, vitality, psychological well-being, and sensory function), rescaled to a 0–100 range, and combined with frailty status to define four IC–frailty phenotypes (concordant frail, discordant low IC, discordant high IC, concordant robust). Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured, and a composite inflammatory burden score (0–3) was derived.</div></div><div><h3>Results</h3><div>The analysis included 311 participants (mean age 85.4 ± 4.7 years, 66.6 % women). Median CRP, IL-6, and TNF-α levels increased progressively from concordant robust to concordant frail groups (<em>p</em> < 0.01). In the fully adjusted model, concordant frail participants had higher inflammation compared with concordant robust (β = 0.71; 95 % CI 0.04–1.37; <em>p</em> = 0.03), while discordant high IC and discordant low IC showed intermediate values without statistical significance. A significant linear trend was observed across ordered phenotypes (β per category increment = 0.21, 95 % CI 0.06 to 0.37). Locomotion and vitality emerged as the domains most strongly linked to inflammation.</div></div><div><h3>Conclusions</h3><div>IC–frailty phenotypes show a biological gradient of subclinical inflammation, with higher IC having lower inflammation levels. Preserved locomotion reflects key functional correlates of resilience and vitality in advanced age.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113026"},"PeriodicalIF":4.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of paroxetine on lifespan, feeding behavior, and other physiological parameters in the nematode C. elegans under a modified bacterial diet 帕罗西汀对改良细菌饮食下秀丽隐杆线虫寿命、摄食行为和其他生理参数的影响。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-05 DOI: 10.1016/j.exger.2025.113022

Abdullah M. Almotayri , Ali H. Alghamdi , K. ELSHERBINY , Ali A. Hroobi , Nourah M. Almimoni , Hussam A. Althagafi , Tariq Saeed Alghamdi , Fatehia N. Gharsan , Mariam S. Alghamdi , Abdullah A.A. Alghamdi

Paroxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is known for its metabolic side effects, yet its long-term physiological impacts remain incompletely understood. This study investigated the effects of paroxetine on lifespan, feeding behavior, and fat accumulation in Caenorhabditis elegans across different developmental stages and dietary conditions. We found that low-dose paroxetine extended lifespan when exposure began early, while high doses consistently reduced lifespan. Notably, the lifespan-extending effects appeared to be diminished when worms were fed a high-glucose diet, suggesting that dietary context may influence the physiological outcomes of paroxetine. Paroxetine also increased food intake without causing fat accumulation, indicating a possible metabolic uncoupling. These effects were independent of major serotonergic, dopaminergic, and insulin-like signaling pathways, pointing to alternative mechanisms. Overall, our findings highlight the potential roles of dose, timing of exposure, and diet in shaping the physiological impacts of SSRIs.

帕罗西汀是一种广泛使用的选择性血清素再摄取抑制剂（SSRI），以其代谢副作用而闻名，但其长期生理影响仍不完全清楚。本研究探讨了帕罗西汀对秀丽隐杆线虫在不同发育阶段和饮食条件下的寿命、摄食行为和脂肪积累的影响。我们发现，低剂量的帕罗西汀在早期接触时会延长寿命，而高剂量的帕罗西汀会持续缩短寿命。值得注意的是，当蠕虫被喂食高葡萄糖食物时，延长寿命的效果似乎减弱了，这表明饮食环境可能会影响帕罗西汀的生理结果。帕罗西汀也增加了食物摄入量，但没有引起脂肪堆积，这表明可能存在代谢解耦。这些影响独立于主要的血清素能、多巴胺能和胰岛素样信号通路，指出了其他机制。总的来说，我们的研究结果强调了剂量、暴露时间和饮食在形成SSRIs生理影响中的潜在作用。

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引用次数: 0

Effect of multicomponent and stability exercises on body composition, physical fitness, and functional movement capability in active older women: a non-randomized study 多组分和稳定性锻炼对活跃老年妇女身体成分、身体健康和功能性运动能力的影响：一项非随机研究

IF 4.3

Experimental gerontology

Pub Date : 2026-01-05 DOI: 10.1016/j.exger.2025.113016

Mila Vukadinović Jurišić , Roberto Roklicer , Anja Obradović , Sandra Stefan , Antonino Bianco , Patrik Drid , Jelena Obradović

Objective

The present study aimed to investigate the effects of specially designed training program based on multicomponent and stability exercises on body composition, physical fitness, and functional movement capability in active older women.

Methods

Thirty active older women (age 69.37 ± 3.66 years; body height 162.59 ± 6.14 cm; body mass 71.25 ± 8.08 kg) were divided into an intervention group (IG, n = 15) and a control group (CG, n = 15). The IG performed 14 weeks of a specially designed training program. Body composition parameters (muscle mass, fat mass, body mass, basal metabolic rate, and visceral fat mass) were assessed using Bioelectrical Impedance Analysis. Physical fitness was measured with Single-Leg Stance (SLS), 8-ft-up-and-go test (8UG), 30-s chair stand test (30-s CST), and Handgrip strength test left/right hand (HGS L/R). The functional movement capability was measured with a Functional Movement Screen (FMS).

Results

After 14 weeks IG significantly improved (p < 0.001) parameters of body composition (muscle mass, fat mass, body mass, body mass index) and physical fitness (8UG, 30-s CST, SLS, HST-R) compared to CG. The improvements in all FMS tests (Deep Squat, Hurdle Step, In-Lune Lunge, Shoulder mobility, Active Straight Leg Raise, Trunk Stability Push-Up, and Rotary Stability) were greater in the IG compared to the CG (p < 0.001). In addition, IG showed higher Total FMS score compared to CG (p < 0.001).

Conclusion

The combination of multicomponent and stability exercises as a novel approach is a convincing strategy that can improve body composition, physical fitness, and functional movement capability among active older women.

目的：本研究旨在探讨基于多组分和稳定性训练的特殊训练方案对活跃老年妇女身体成分、体质和功能运动能力的影响。方法:30活跃的老年妇女(年龄69.37 ±3.66  年;身体高度162.59 ±6.14  厘米;体重71.25 ±8.08  公斤)被分成一个干预组(搞笑,n = 15)和对照组(CG, n = 15)。IG进行了14周 特别设计的培训计划。使用生物电阻抗分析评估身体组成参数（肌肉质量、脂肪质量、体重、基础代谢率和内脏脂肪质量）。采用单腿站立（SLS）、8英尺起跑测试（8UG）、30秒椅站测试（30秒CST）和左手/右手握力测试（HGS L/R）进行体能测试。用功能运动屏幕（FMS）测量功能运动能力。结果：14 周后IG显著改善（p ）结论：多组分和稳定性训练相结合作为一种新颖的方法是一种令人信服的策略，可以改善活跃老年妇女的身体成分，身体健康和功能运动能力。

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引用次数: 0

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults 中性粒细胞百分比-白蛋白比率在美国成人中风和心力衰竭之间的中介作用。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-01 DOI: 10.1016/j.exger.2025.113010

Yan Zhao , Tingting Chen , Conghua Ji , Yuxin Shang , Yuqing Pan , Wei Mao

Background

Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether the NPAR mediates the relationship between stroke and HF.

Methods

We analyzed data from 42,101 adults in the NHANES. Multivariable regression models adjusted for confounders were used to assess associations of stroke with NPAR and HF. Restricted cubic spline (RCS) curves were employed to investigate potential non-linear or linear relationships between NPAR and HF. Furthermore, mediation analysis was performed to assess the potential mediating role of NPAR.

Results

NPAR levels of participants with HF and/or stroke were higher than those without HF and stroke (P < 0.0001). Following full adjustment, stroke was positively associated with NPAR (β = 0.421, 95 % CI = 0.242, 0.600, P < 0.0001), with stronger associations noted in females (interaction β = 0.450, interaction p-value < 0.001). Similarly, stroke was positively associated with HF (OR = 3.0301, 95 % CI = 2.4143, 3.8030, P < 0.0001). RCS analysis further revealed a nonlinear correlation between NPAR and HF. Furthermore, mediation analysis revealed that NPAR significantly mediated the relationship between stroke and HF (proportion mediated = 3.58 %, P < 0.0001).

Conclusion

This study identified that stroke and NPAR are significantly related to HF, which increases the risk of HF in the adults, and the mediating role of NPAR is significant in the relationship between stroke and HF. This finding highlights the necessity of regulating the inflammatory-nutritional.

背景：卒中是心力衰竭（HF）的独立危险因素，两者都与全身性炎症有关。中性粒细胞百分比与白蛋白比率（NPAR）是一种新的炎症生物标志物。然而，NPAR是否在脑卒中和心衰之间起中介作用尚不清楚。方法：我们分析了来自NHANES的42101名成年人的数据。采用校正混杂因素的多变量回归模型来评估卒中与NPAR和HF的关联。限制三次样条（RCS）曲线用于研究NPAR与HF之间潜在的非线性或线性关系。此外，我们还进行了中介分析，以评估NPAR的潜在中介作用。结果：HF和/或卒中患者的NPAR水平高于无HF和卒中患者（P ）。结论：本研究发现卒中和NPAR与HF显著相关，其增加了成人HF的风险，NPAR在卒中和HF之间的中介作用显著。这一发现强调了调节炎症-营养的必要性。

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引用次数: 0

Autonomous fall risk assessment in Australian Residential Aged Care Facilities using passive sensors: A feasibility study 澳大利亚住宅养老设施中使用被动传感器的自主跌倒风险评估：可行性研究。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-01 DOI: 10.1016/j.exger.2025.113013

David Silvera-Tawil , Jane Li , Liesel Higgins , Deepa Prabhu , Jennifer Hewitt , Katie Packer , Wei Lu , Maggie Haertsch , Marlien Varnfield

Background

Falls in residential aged care home (RAC) remain a critical issue in Australia, contributing to diminished quality of life and increased morbidity among older adults. This study investigates the feasibility of passive sensor technologies to proactively identify behavioural changes, such as reduced mobility and sleep disturbances, that may signal elevated fall risk. It also explores resident and staff acceptance of the technology.

Methods

An open-label, non-randomized feasibility trial using a single-group, post-test mixed methods design was conducted with 24 residents at a RAC in Sydney, Australia. Ambient and wearable sensor data and clinical records were collected, alongside interviews with residents and staff. Data were analysed using quantitative and qualitative techniques to assess feasibility and user experience.

Results

Sensor data revealed diverse resident routines and rapid staff responses to alerts. Predictive analytics showed promise for identifying elevated fall risk, though further validation is needed. Qualitative feedback from 10 residents indicated residents found the system mostly unobtrusive but raised concerns around privacy and false alerts that triggered staff interventions. Despite this, many residents acknowledged its value, especially for individuals with higher vulnerability. Interviews with eight staff members echoed the system's potential to enhance monitoring and safety, but noted technical and training challenges.

Conclusion

The study demonstrates that sensor-based monitoring in RACs is technically feasible and generally acceptable. The findings support its integration into aged care as a proactive, person-centred approach to falls management, provided that implementation is supported by thoughtful design, clear communication, and staff training.

背景：在澳大利亚，养老院（RAC）跌倒仍然是一个关键问题，导致老年人生活质量下降和发病率增加。这项研究调查了被动传感器技术的可行性，以主动识别行为变化，如活动能力下降和睡眠障碍，这可能预示着跌倒风险的增加。它还探讨了居民和工作人员对这项技术的接受程度。方法：对澳大利亚悉尼某RAC的24名居民进行了一项开放标签、非随机可行性试验，采用单组、试验后混合方法设计。收集环境和可穿戴传感器数据和临床记录，以及与居民和工作人员的访谈。使用定量和定性技术分析数据，以评估可行性和用户体验。结果：传感器数据揭示了不同的居民惯例和快速的工作人员对警报的反应。预测分析显示，尽管需要进一步验证，但仍有望识别出较高的跌倒风险。来自10位居民的定性反馈表明，居民们认为该系统大多不引人注目，但引发了对隐私和错误警报的担忧，引发了工作人员的干预。尽管如此，许多居民还是承认它的价值，尤其是对那些易受伤害的人。对8名工作人员的采访反映了该系统在加强监测和安全方面的潜力，但也指出了技术和培训方面的挑战。结论：本研究表明，基于传感器的rac监测在技术上是可行的，并且被普遍接受。研究结果支持将其作为一种主动的、以人为本的跌倒管理方法纳入老年护理，前提是实施过程中要有周到的设计、清晰的沟通和人员培训。

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引用次数: 0

Qiliqiangxin capsule improves the cognitive disorders in heart failure rats through regulating blood brain barrier function 七理强心胶囊通过调节血脑屏障功能改善心力衰竭大鼠认知障碍。

IF 4.3

Experimental gerontology

Pub Date : 2026-01-01 DOI: 10.1016/j.exger.2025.113007

Hongbing Zhao , Yue Zhao , Jinfang Dou , Murong Hei , Yuqian Gao , Jiaran Peng , Zhimiao Wang , Shuai Zhang , Haiyan Zhu

Objective

This study aimed to investigate the protective effects of Qiliqiangxin capsule (QLQX) against cognitive impairment in rats with heart failure (HF), as well as the underlying mechanisms.

Materials and methods

Heart failure was induced in rats by LAD ligation. The animals were randomized into four groups (sham, model, QLQX [0.6 g/kg/d], and valsartan [13.3 mg/kg/d]) and received treatment for 60 days. Cardiac function was evaluated by echocardiography, while cognitive function was assessed using the Morris water maze. Myocardial and hippocampal morphology were examined by HE and Nissl staining, respectively. Hippocampal levels of Ang II, Aβ₄₂, and ROS were quantified via ELISA and DHE staining. Finally, Western blot analysis was performed to measure the expression of AT1R, NF-κB, P-gP, RAGE, and the tight junction proteins (Claudin-5, Occludin).

Results

Echocardiographic assessments revealed that QLQX significantly improved cardiac function in rats with HF-induced cognitive impairment. The Morris water maze test demonstrated that, compared with the model group, QLQX treatment enhanced the targeting of swimming path and increased the number of platform crossings—consistently indicating alleviation of cognitive dysfunction. Histological analysis using HE staining confirmed that QLQX preserved myocardial structural integrity. Nissl staining further demonstrated that QLQX mitigated neuronal damage in the hippocampus. Additionally, QLQX reduced the levels of Ang II, AT1R, ROS, and Aβ_42. It also downregulated the expression of NF-κB and P-gP while upregulating that of Claudin-5 and Occludin.

Conclusions

QLQX improves cardiac function and mitigates cognitive decline in rats with heart failure. These protective effects likely involve the reduction of Ang II, AT1R, and ROS levels, alongside inhibition of the NF-κB pathway. Furthermore, QLQX upregulates the tight junction proteins Claudin-5 and Occludin, which helps preserve blood-brain barrier (BBB) integrity. This cascade of events ultimately reduces cerebral Aβ deposition.

目的：探讨七理强心胶囊（QLQX）对心力衰竭（HF）大鼠认知功能障碍的保护作用及其机制。材料与方法：采用LAD结扎法诱导大鼠心力衰竭。随机分为假药组、模型组、QLQX[0.6 g/kg/d]、缬沙坦[13.3 mg/kg/d] 4组，疗程60 d。超声心动图评估心功能，Morris水迷宫评估认知功能。HE染色、尼氏染色观察大鼠心肌和海马形态。通过ELISA和DHE染色，定量测定海马Ang II、a - β42和ROS水平。最后采用Western blot检测AT1R、NF-κB、P-gP、RAGE和紧密连接蛋白（Claudin-5、Occludin）的表达。结果：超声心动图评估显示，QLQX可显著改善hf诱导的认知功能障碍大鼠的心功能。Morris水迷宫实验显示，与模型组相比，QLQX治疗增强了游泳路径的靶向性，增加了穿越平台的次数，一致表明认知功能障碍得到缓解。HE染色组织学分析证实，QLQX保留了心肌结构的完整性。尼氏染色进一步表明，QLQX减轻了海马神经元损伤。此外，QLQX还能降低Ang II、AT1R、ROS和a - β42的水平。下调NF-κB和P-gP的表达，上调Claudin-5和Occludin的表达。结论：QLQX可改善心力衰竭大鼠心功能，减轻认知能力下降。这些保护作用可能包括降低Ang II、AT1R和ROS水平，以及抑制NF-κB途径。此外，QLQX上调紧密连接蛋白Claudin-5和Occludin，这有助于保持血脑屏障（BBB）的完整性。这一连串的事件最终减少了大脑中Aβ的沉积。

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引用次数: 0