Experimental gerontology最新文献

{"title":"Quercetin rejuvenates aged adipose progenitor cells by attenuating inflammatory pathways","authors":"Junwan Fan ,&nbsp;Ling Zhou ,&nbsp;Run Song ,&nbsp;Fuqiang Yang ,&nbsp;Yingjie Geng ,&nbsp;Xueyu Zhang ,&nbsp;Qiuhua Yu ,&nbsp;Zirui Li ,&nbsp;Yan Wang ,&nbsp;Wenyan He","doi":"10.1016/j.exger.2026.113027","DOIUrl":"10.1016/j.exger.2026.113027","url":null,"abstract":"<div><div>The mass of inguinal white adipose tissue (iWAT) decreases with age, and its dysfunction contributes to systemic effects, including chronic inflammation, ectopic lipid deposition, and insulin resistance. However, the molecular and functional characteristics of aged adipose progenitor cells (APCs), as well as effective strategies to rejuvenate their adipogenic potential, remain poorly understood. In this study, we found that aged mice exhibited a reduced frequency of APCs, increased inflammatory activity, and impaired adipogenic differentiation capacity. Strikingly, while quercetin exerted concentration-dependent effects on the vitality and function of APCs, only moderate doses specifically restored the adipogenic differentiation of aged APCs. Mechanistically, this rejuvenating effect was primarily mediated through the suppression of pro-inflammatory pathways. Together, our findings provide novel mechanistic insights into APCs aging in iWAT and identify quercetin as a promising rejuvenative agent for the treatment of adipose tissue dysfunction and related metabolic disorders in aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113027"},"PeriodicalIF":4.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity–frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study","authors":"Stefano Cacciatore ,&nbsp;Riccardo Calvani ,&nbsp;Konstantinos Prokopidis ,&nbsp;Mathias Schlögl ,&nbsp;Andrea Russo ,&nbsp;Matteo Tosato ,&nbsp;Stephen D. Anton ,&nbsp;Christiaan Leeuwenburgh ,&nbsp;John A. Batsis ,&nbsp;Emanuele Marzetti ,&nbsp;Francesco Landi","doi":"10.1016/j.exger.2026.113026","DOIUrl":"10.1016/j.exger.2026.113026","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC–frailty phenotypes and systemic inflammation in community-dwelling octogenarians and identify IC domains most closely related to inflammatory burden.</div></div><div><h3>Methods</h3><div>IC was assessed across five domains (locomotion, cognition, vitality, psychological well-being, and sensory function), rescaled to a 0–100 range, and combined with frailty status to define four IC–frailty phenotypes (concordant frail, discordant low IC, discordant high IC, concordant robust). Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured, and a composite inflammatory burden score (0–3) was derived.</div></div><div><h3>Results</h3><div>The analysis included 311 participants (mean age 85.4 ± 4.7 years, 66.6 % women). Median CRP, IL-6, and TNF-α levels increased progressively from concordant robust to concordant frail groups (<em>p</em> &lt; 0.01). In the fully adjusted model, concordant frail participants had higher inflammation compared with concordant robust (β = 0.71; 95 % CI 0.04–1.37; <em>p</em> = 0.03), while discordant high IC and discordant low IC showed intermediate values without statistical significance. A significant linear trend was observed across ordered phenotypes (β per category increment = 0.21, 95 % CI 0.06 to 0.37). Locomotion and vitality emerged as the domains most strongly linked to inflammation.</div></div><div><h3>Conclusions</h3><div>IC–frailty phenotypes show a biological gradient of subclinical inflammation, with higher IC having lower inflammation levels. Preserved locomotion reflects key functional correlates of resilience and vitality in advanced age.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113026"},"PeriodicalIF":4.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of paroxetine on lifespan, feeding behavior, and other physiological parameters in the nematode C. elegans under a modified bacterial diet","authors":"Abdullah M. Almotayri ,&nbsp;Ali H. Alghamdi ,&nbsp;K. ELSHERBINY ,&nbsp;Ali A. Hroobi ,&nbsp;Nourah M. Almimoni ,&nbsp;Hussam A. Althagafi ,&nbsp;Tariq Saeed Alghamdi ,&nbsp;Fatehia N. Gharsan ,&nbsp;Mariam S. Alghamdi ,&nbsp;Abdullah A.A. Alghamdi","doi":"10.1016/j.exger.2025.113022","DOIUrl":"10.1016/j.exger.2025.113022","url":null,"abstract":"<div><div>Paroxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is known for its metabolic side effects, yet its long-term physiological impacts remain incompletely understood. This study investigated the effects of paroxetine on lifespan, feeding behavior, and fat accumulation in <em>Caenorhabditis elegans</em> across different developmental stages and dietary conditions. We found that low-dose paroxetine extended lifespan when exposure began early, while high doses consistently reduced lifespan. Notably, the lifespan-extending effects appeared to be diminished when worms were fed a high-glucose diet, suggesting that dietary context may influence the physiological outcomes of paroxetine. Paroxetine also increased food intake without causing fat accumulation, indicating a possible metabolic uncoupling. These effects were independent of major serotonergic, dopaminergic, and insulin-like signaling pathways, pointing to alternative mechanisms. Overall, our findings highlight the potential roles of dose, timing of exposure, and diet in shaping the physiological impacts of SSRIs.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113022"},"PeriodicalIF":4.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of multicomponent and stability exercises on body composition, physical fitness, and functional movement capability in active older women: a non-randomized study","authors":"Mila Vukadinović Jurišić ,&nbsp;Roberto Roklicer ,&nbsp;Anja Obradović ,&nbsp;Sandra Stefan ,&nbsp;Antonino Bianco ,&nbsp;Patrik Drid ,&nbsp;Jelena Obradović","doi":"10.1016/j.exger.2025.113016","DOIUrl":"10.1016/j.exger.2025.113016","url":null,"abstract":"<div><h3>Objective</h3><div>The present study aimed to investigate the effects of specially designed training program based on multicomponent and stability exercises on body composition, physical fitness, and functional movement capability in active older women.</div></div><div><h3>Methods</h3><div>Thirty active older women (age 69.37 ± 3.66 years; body height 162.59 ± 6.14 cm; body mass 71.25 ± 8.08 kg) were divided into an intervention group (IG, <em>n</em> = 15) and a control group (CG, n = 15). The IG performed 14 weeks of a specially designed training program. Body composition parameters (muscle mass, fat mass, body mass, basal metabolic rate, and visceral fat mass) were assessed using Bioelectrical Impedance Analysis. Physical fitness was measured with Single-Leg Stance (SLS), 8-ft-up-and-go test (8UG), 30-s chair stand test (30-s CST), and Handgrip strength test left/right hand (HGS L/R). The functional movement capability was measured with a Functional Movement Screen (FMS).</div></div><div><h3>Results</h3><div>After 14 weeks IG significantly improved (<em>p</em> &lt; 0.001) parameters of body composition (muscle mass, fat mass, body mass, body mass index) and physical fitness (8UG, 30-s CST, SLS, HST-R) compared to CG. The improvements in all FMS tests (Deep Squat, Hurdle Step, In-Lune Lunge, Shoulder mobility, Active Straight Leg Raise, Trunk Stability Push-Up, and Rotary Stability) were greater in the IG compared to the CG (p &lt; 0.001). In addition, IG showed higher Total FMS score compared to CG (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of multicomponent and stability exercises as a novel approach is a convincing strategy that can improve body composition, physical fitness, and functional movement capability among active older women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113016"},"PeriodicalIF":4.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults","authors":"Yan Zhao ,&nbsp;Tingting Chen ,&nbsp;Conghua Ji ,&nbsp;Yuxin Shang ,&nbsp;Yuqing Pan ,&nbsp;Wei Mao","doi":"10.1016/j.exger.2025.113010","DOIUrl":"10.1016/j.exger.2025.113010","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether the NPAR mediates the relationship between stroke and HF.</div></div><div><h3>Methods</h3><div>We analyzed data from 42,101 adults in the NHANES. Multivariable regression models adjusted for confounders were used to assess associations of stroke with NPAR and HF. Restricted cubic spline (RCS) curves were employed to investigate potential non-linear or linear relationships between NPAR and HF. Furthermore, mediation analysis was performed to assess the potential mediating role of NPAR.</div></div><div><h3>Results</h3><div>NPAR levels of participants with HF and/or stroke were higher than those without HF and stroke (<em>P</em> &lt; 0.0001). Following full adjustment, stroke was positively associated with NPAR (β = 0.421, 95 % CI = 0.242, 0.600, <em>P</em> &lt; 0.0001), with stronger associations noted in females (interaction β = 0.450, interaction <em>p</em>-value &lt; 0.001). Similarly, stroke was positively associated with HF (OR = 3.0301, 95 % CI = 2.4143, 3.8030, <em>P</em> &lt; 0.0001). RCS analysis further revealed a nonlinear correlation between NPAR and HF. Furthermore, mediation analysis revealed that NPAR significantly mediated the relationship between stroke and HF (proportion mediated = 3.58 %, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>This study identified that stroke and NPAR are significantly related to HF, which increases the risk of HF in the adults, and the mediating role of NPAR is significant in the relationship between stroke and HF. This finding highlights the necessity of regulating the inflammatory-nutritional.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113010"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomous fall risk assessment in Australian Residential Aged Care Facilities using passive sensors: A feasibility study","authors":"David Silvera-Tawil ,&nbsp;Jane Li ,&nbsp;Liesel Higgins ,&nbsp;Deepa Prabhu ,&nbsp;Jennifer Hewitt ,&nbsp;Katie Packer ,&nbsp;Wei Lu ,&nbsp;Maggie Haertsch ,&nbsp;Marlien Varnfield","doi":"10.1016/j.exger.2025.113013","DOIUrl":"10.1016/j.exger.2025.113013","url":null,"abstract":"<div><h3>Background</h3><div>Falls in residential aged care home (RAC) remain a critical issue in Australia, contributing to diminished quality of life and increased morbidity among older adults. This study investigates the feasibility of passive sensor technologies to proactively identify behavioural changes, such as reduced mobility and sleep disturbances, that may signal elevated fall risk. It also explores resident and staff acceptance of the technology.</div></div><div><h3>Methods</h3><div>An open-label, non-randomized feasibility trial using a single-group, post-test mixed methods design was conducted with 24 residents at a RAC in Sydney, Australia. Ambient and wearable sensor data and clinical records were collected, alongside interviews with residents and staff. Data were analysed using quantitative and qualitative techniques to assess feasibility and user experience.</div></div><div><h3>Results</h3><div>Sensor data revealed diverse resident routines and rapid staff responses to alerts. Predictive analytics showed promise for identifying elevated fall risk, though further validation is needed. Qualitative feedback from 10 residents indicated residents found the system mostly unobtrusive but raised concerns around privacy and false alerts that triggered staff interventions. Despite this, many residents acknowledged its value, especially for individuals with higher vulnerability. Interviews with eight staff members echoed the system's potential to enhance monitoring and safety, but noted technical and training challenges.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that sensor-based monitoring in RACs is technically feasible and generally acceptable. The findings support its integration into aged care as a proactive, person-centred approach to falls management, provided that implementation is supported by thoughtful design, clear communication, and staff training.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113013"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qiliqiangxin capsule improves the cognitive disorders in heart failure rats through regulating blood brain barrier function","authors":"Hongbing Zhao ,&nbsp;Yue Zhao ,&nbsp;Jinfang Dou ,&nbsp;Murong Hei ,&nbsp;Yuqian Gao ,&nbsp;Jiaran Peng ,&nbsp;Zhimiao Wang ,&nbsp;Shuai Zhang ,&nbsp;Haiyan Zhu","doi":"10.1016/j.exger.2025.113007","DOIUrl":"10.1016/j.exger.2025.113007","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the protective effects of Qiliqiangxin capsule (QLQX) against cognitive impairment in rats with heart failure (HF), as well as the underlying mechanisms.</div></div><div><h3>Materials and methods</h3><div>Heart failure was induced in rats by LAD ligation. The animals were randomized into four groups (sham, model, QLQX [0.6 g/kg/d], and valsartan [13.3 mg/kg/d]) and received treatment for 60 days. Cardiac function was evaluated by echocardiography, while cognitive function was assessed using the Morris water maze. Myocardial and hippocampal morphology were examined by HE and Nissl staining, respectively. Hippocampal levels of Ang II, Aβ₄₂, and ROS were quantified via ELISA and DHE staining. Finally, Western blot analysis was performed to measure the expression of AT1R, NF-κB, P-gP, RAGE, and the tight junction proteins (Claudin-5, Occludin).</div></div><div><h3>Results</h3><div>Echocardiographic assessments revealed that QLQX significantly improved cardiac function in rats with HF-induced cognitive impairment. The Morris water maze test demonstrated that, compared with the model group, QLQX treatment enhanced the targeting of swimming path and increased the number of platform crossings—consistently indicating alleviation of cognitive dysfunction. Histological analysis using HE staining confirmed that QLQX preserved myocardial structural integrity. Nissl staining further demonstrated that QLQX mitigated neuronal damage in the hippocampus. Additionally, QLQX reduced the levels of Ang II, AT1R, ROS, and Aβ_42. It also downregulated the expression of NF-κB and P-gP while upregulating that of Claudin-5 and Occludin.</div></div><div><h3>Conclusions</h3><div>QLQX improves cardiac function and mitigates cognitive decline in rats with heart failure. These protective effects likely involve the reduction of Ang II, AT1R, and ROS levels, alongside inhibition of the NF-κB pathway. Furthermore, QLQX upregulates the tight junction proteins Claudin-5 and Occludin, which helps preserve blood-brain barrier (BBB) integrity. This cascade of events ultimately reduces cerebral Aβ deposition.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113007"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism","authors":"Yujie Zhang ,&nbsp;Zhe Pan ,&nbsp;Jiewen Shi ,&nbsp;Jingjing Zhang ,&nbsp;Yongli Chai ,&nbsp;Ye Zhao ,&nbsp;Wei Liu ,&nbsp;Wei'’an Yuan","doi":"10.1016/j.exger.2025.113001","DOIUrl":"10.1016/j.exger.2025.113001","url":null,"abstract":"<div><h3>Background</h3><div>The total flavonoids of Epimedii Folium (<em>Epimedium brevicornu Maxim.</em>) are the main active component, and have unique advantages in sarcopenia intervention. Nevertheless, its efficacy and mechanism of action have not been reported in the literature.</div></div><div><h3>Aim of the study</h3><div>This study aimed to evaluate the impact of TFE on sarcopenia and to elucidate the mechanisms involving the FXR-FGF15 signaling pathway and the gut microbiota-bile acid-skeletal muscle axis.</div></div><div><h3>Methods</h3><div>At the cellular level, the effects of TFE on C2C12 myotube morphology, as well as on myogenic growth factors and atrophy-related markers, were evaluated. At the animal level, the effects of TFE on sarcopenia were investigated through assessments of senescence score, grip strength, body composition, running performance, and histological analysis of skeletal muscle tissue. The levels of inflammatory cytokines in serum were assayed using ELISA to assess the inflammation. Pyrosequencing of bacterial 16S rRNA from the V3–V4 of fecal samples characterized the gut microbiota. Targeted bile acid metabolomics in fecal and skeletal muscle samples were measured using UHPLC-Q-Exactive Orbitrap HRMS. qRT-PCR and western blot were used to evaluate markers related to bile acid synthesis, transport, and absorption, as well as the FXR-FGF15 signaling pathway.</div></div><div><h3>Results</h3><div>TFE helps prevent dexamethasone-induced muscle atrophy and degeneration by upregulating the expression of myogenic growth factors (MyoD, Mef2a, and MyoG) and downregulating the expression of muscle atrophy markers (Trim63, Fbxo32). 12 weeks TFE administration has significant therapeutic properties in SAMP8 mice, as demonstrated by lower senescence score and body fat content; greater grip force, lean muscle content and muscle function (running time and distance), and have the effects of delaying the progression of aging and repairing the pathological damage of skeletal muscle in the SAMP8 mice. Its mechanism of action may involve restoring gut microbiota imbalance and bile acid metabolism disruption, thereby positively regulating FXR-FGF15 signaling.</div></div><div><h3>Conclusions</h3><div>In the present study, TFE was shown to improve dexamethasone-induced muscle atrophy and degeneration in C2C12 myotubes, as evidenced by the restored expression of myogenic markers and the downregulation of atrophy-related genes and proteins. Additionally, TFE can attenuate sarcopenia progression in SAMP8 mice. Its effect was related to the regulation of the gut microbiota-bile acids-skeletal muscle axis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113001"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia, obesity, and functional decline: converging mechanisms and emerging diagnostic frontiers","authors":"Andrea P. Rossi ,&nbsp;Lin Kang ,&nbsp;Ming Yang","doi":"10.1016/j.exger.2025.112993","DOIUrl":"10.1016/j.exger.2025.112993","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112993"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The skeletal muscle function deficit: From an operational definition to clinic results from the InCHIANTI longitudinal study","authors":"Angelo Di Iorio ,&nbsp;Raffaello Pellegrino ,&nbsp;Roberto Paganelli ,&nbsp;Matteo Candeloro ,&nbsp;Stefania Bandinelli ,&nbsp;Toshiko Tanaka ,&nbsp;Luigi Ferrucci","doi":"10.1016/j.exger.2025.113018","DOIUrl":"10.1016/j.exger.2025.113018","url":null,"abstract":"<div><div>Age-related muscle dysfunction is a major contributor to disability, frailty, and poor clinical outcomes in older adults. Skeletal Muscle Function Deficit (SMFD) framework integrates multiple domains as: muscle mass, muscle density, strength, and power to capture a broader spectrum of age-related muscle dysfunction. The primary aims of these analyses are to develop and validate a composite SMFD score and evaluate its association with key geriatric outcome.</div><div>This study used data from the InCHIANTI follow-up study, involving an initial cohort of 1035 older participants, with a total of 3196 assessments. The SMFD score was computed by assigning quintile-based values of muscle area, density, strength, and lower limb power. Associations with adverse health outcomes, and major chronic diseases were analyzed using mixed-effects models.</div><div>The SMFD score declined over time from baseline to the third follow-up was: β ± SE:-0.64 ± 0.12 (<em>p</em>-value &lt; 0.001), β ± SE:-1.94 ± 0.13 (p-value &lt; 0.001), and β ± SE:-4.43 ± 0.14 (p-value &lt; 0.001), respectively, and was associated with: BADL (OR = 0.57; 95 %CI: 0.46–0.69), IADL (OR = 0.70; 95 %CI: 0.66–0.75), poor physical performance (SPPB &lt; 7) (OR = 0.68; 95 %CI: 0.64–0.73), Fried's frailty phenotype (OR = 0.72; 95 % CI: 0.68–0.76), hospitalization (OR = 0.96; 95 %CI: 0.93–0.99), and falls' number (OR = 0.96; 95 %CI: 0.92–0.99). Whereas higher SMFD scores were negatively associated with Parkinson's disease, stroke, and hip osteoarthritis.</div><div>The SMFD score is a valid, multidimensional measure that predicts adverse outcomes in older adults. It holds promise for use in clinical assessment, risk stratification, and targeted interventions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113018"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}