Experimental gerontology最新文献_第5页

Prevalence and factors influencing preoperative frailty in elderly patients with gynecologic oncology surgery: A cross-sectional study 妇科肿瘤手术老年患者术前虚弱的发生率和影响因素：一项横断面研究。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-27 DOI: 10.1016/j.exger.2025.112691

Xiaofang Wu , Shuo Man , Haowen Huang , Jinjin Yu , Ling Xia

Background

Frailty is an important predictor of poor postoperative outcomes in elderly patients with gynaecologic cancer. However, the prevalence and risk factors for frailty in this population remain unclear.

Methods

This cross-sectional study was conducted simultaneously in three gynecology departments of a tertiary hospital in China between January and March 2024. The study recruited 126 hospitalised patients with gynaecologic malignancies who underwent surgery. The demographic and clinical characteristics and biochemical laboratory parameters of all patients were collected. The Edmonton Frailty Scale was used to assess the patient's frailty. Multivariate logistic regression model analysis was used to identify the influencing factors of frailty.

Results

The prevalence of preoperative frailty was 31 %. Univariate analysis showed significant differences between frail and non-frail groups in terms of age, body mass index, menopausal status, self-management ability, nutritional risk and activities of daily living (ADL) (all p < 0.05). Multiple logistic regression analysis identified older age (odds ratio [OR] = 1.27, 95%CI: 1.068–1.511, p = 0.007), ADL disability (OR = 3.184, 95%CI: 2.294–4.833, p = 0.010) and high nutritional risk (Nutritional Risk Screening 2002 score ≥ 3) (OR = 4.823, 95%CI: 1.422–16.816, p = 0.031) as risk factors for frailty. High self-management ability (OR = 0.918, 95%CI: 0.844–0.998, p = 0.046) was a protective factor against frailty.

Conclusion

Nutritional support, activity exercise and improvement of patient self-management are potential intervention goals, and nurses should develop targeted prevention strategies based on identified risk factors to protect patient health.

{"title":"Prevalence and factors influencing preoperative frailty in elderly patients with gynecologic oncology surgery: A cross-sectional study","authors":"Xiaofang Wu , Shuo Man , Haowen Huang , Jinjin Yu , Ling Xia","doi":"10.1016/j.exger.2025.112691","DOIUrl":"10.1016/j.exger.2025.112691","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is an important predictor of poor postoperative outcomes in elderly patients with gynaecologic cancer. However, the prevalence and risk factors for frailty in this population remain unclear.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted simultaneously in three gynecology departments of a tertiary hospital in China between January and March 2024. The study recruited 126 hospitalised patients with gynaecologic malignancies who underwent surgery. The demographic and clinical characteristics and biochemical laboratory parameters of all patients were collected. The Edmonton Frailty Scale was used to assess the patient's frailty. Multivariate logistic regression model analysis was used to identify the influencing factors of frailty.</div></div><div><h3>Results</h3><div>The prevalence of preoperative frailty was 31 %. Univariate analysis showed significant differences between frail and non-frail groups in terms of age, body mass index, menopausal status, self-management ability, nutritional risk and activities of daily living (ADL) (all <em>p</em> < 0.05). Multiple logistic regression analysis identified older age (odds ratio [OR] = 1.27, 95%CI: 1.068–1.511, <em>p</em> = 0.007), ADL disability (OR = 3.184, 95%CI: 2.294–4.833, <em>p</em> = 0.010) and high nutritional risk (Nutritional Risk Screening 2002 score ≥ 3) (OR = 4.823, 95%CI: 1.422–16.816, <em>p</em> = 0.031) as risk factors for frailty. High self-management ability (OR = 0.918, 95%CI: 0.844–0.998, <em>p</em> = 0.046) was a protective factor against frailty.</div></div><div><h3>Conclusion</h3><div>Nutritional support, activity exercise and improvement of patient self-management are potential intervention goals, and nurses should develop targeted prevention strategies based on identified risk factors to protect patient health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112691"},"PeriodicalIF":3.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased serum PF4 levels correlate with cognitive decline and CSF biomarkers in Alzheimer's disease in a Chinese cohort

IF 3.9

Experimental gerontology

Pub Date : 2025-01-24 DOI: 10.1016/j.exger.2025.112689

Hao Sun , Dong-Wan Chen , Yuan-Ye Ma , Bai Liu , Jun Wang , Yu-Jie Lai , Gui-Hua Zeng , Ying-Ying Shen , Cheng-Rong Tan , Xian-Le Bu , Fan Zeng , Yan-Jiang Wang

Background

Platelet factor 4 (PF4), a chemotactic factor secreted from the α-granules of platelets, has recently been proved to mitigate neuroinflammation and improve aging-related cognition decline, which may be involved in Alzheimer's disease (AD).

Objective

This study aims to investigate the alterations of serum PF4 levels in AD, the correlation between serum PF4 and β-amyloid (Aβ) and tau levels in cerebrospinal fluid (CSF), and the potential diagnostic utility of PF4 in AD.

Methods

A cross-sectional study was conducted involving 38 amyloid-positive AD patients and 50 cognitively normal controls. The levels of serum PF4 were detected using the Human CXCL4/PF4 enzyme-linked immunosorbent assay (ELISA) Kit. The levels of CSF Aβ42, Aβ40, p-tau181, and t-tau were measured on the fully-automated Lumipulse G1200 platform via commercially available kits.

Results

The levels of serum PF4 were significantly decreased in AD patients (5163.51 (3198.24–6301.15) vs. 5859.29 (4126.06–8006.70), Z = −2.30, P = 0.021). The negative correlation between AD diagnosis (β = −1972.292, P = 0.009) and PF4 levels retained after the adjustments of age, sex, APOE ε4 status, platelet count, platelet distribution width (PDW), and comorbidity of dyslipidemia in the multiple linear regression analysis. Further analysis showed that serum PF4 levels were positively correlated with CSF Aβ42 levels and Mini-Mental State Examination (MMSE) scores, and negatively correlated with CSF t-tau levels. Besides, the area under the curve (AUC) of serum PF4 for AD (AUC = 0.6437, P = 0.022) was comparable to that of CSF Aβ40 (AUC = 0.6400) yet lower than those of CSF Aβ42, ptau181, and t-tau. The AUC slightly increased when combining serum PF4 with other CSF AD biomarkers separately.

Conclusions

The serum levels of PF4 were decreased in AD patients and were significantly correlated with the cognitive function and CSF levels of Aβ42 and t-tau. PF4 may become a promising anti-aging and therapeutic target for AD, which is worthy of further study.

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引用次数: 0

Acute and time-course changes in hemodynamic and physical performance parameters following single and multiple resistance training sets in cognitively impaired individuals: A randomized crossover study

IF 3.9

Experimental gerontology

Pub Date : 2025-01-23 DOI: 10.1016/j.exger.2025.112688

Nuno Fonseca , Dulce Esteves , Diogo Luís Marques , Luís Brandão Faíl , Tiago Sousa , Mafalda Pamplona Pinto , Henrique Pereira Neiva , Mikel Izquierdo , Mário Cardoso Marques

This study analyzed the acute and time-course changes following one resistance training (RT) set (1SET) and three sets (3SET) on hemodynamic and physical performance parameters in individuals with different cognitive impairment levels. Thirty-nine individuals (22 women and 17 men aged 80 ± 9 years) grouped by cognitive impairment (mild [MILD], moderate [MOD], and severe [SEV]) randomly performed two protocols, each separated by one week, of 1SET or 3SET of 10 repetitions. Before (PRE), immediately (POST), and 72 h after (POST72) protocols, the participants performed the following measurements: systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), 1-kg medicine ball throw (MBT) distance, five-repetition sit-to-stand (STS) time, and handgrip strength (HGS). A three-way ANOVA with repeated measures revealed no significant differences between 1SET and 3SET on SBP, DBP, HR, STS, MBT, and HGS in any group at any time (all p ≥ 0.05). SEV increased SBP and HR from PRE to POST and decreased STS time after 3SET. From POST to POST72, all groups decreased SBP after both protocols, and SEV improved STS time after 3SET and HGS following both protocols. Furthermore, from PRE to POST72, MILD decreased SBP, while SEV improved HGS following 1SET and STS time following 3SET. These findings demonstrate that single and multiple sets cause acute hemodynamic changes, with a tendency to reduce SBP within 72 h. Additionally, individuals with worse cognitive function showed greater adaptive responses over time in physical performance, with 1SET improving HGS and 3SET enhancing STS performance.

Trial registration: ClinicalTrials.gov ID: NCT06185010

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引用次数: 0

Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China 中国老年人握力不对称和无力与内在能力障碍的关系。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112656

Decheng Li , Yunhe Wang , Shuai Guo , Ziyang Ren , Binbin Su , Lichuan Zhang , Zuliyaer Talifu , Xiaoying Zheng

Background

Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts.

Methods

We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS). IC was evaluated across cognitive, locomotion, psychological, sensory, and vitality domains. Asymmetry and weakness were measured using the maximum value of HGS. Logistic regression models were employed to examine the association of the individual and combined groupings of HGS asymmetry and weakness with IC impairment (a total score ≥ 2 across five domains). The potential non-linear relationship was explored using a restricted cubic spline (RCS) model.

Results

Of the 4798 participants included (median age 66.0 years, IQR 63.0–71.0 years; 56.9 % male), 35.2 % had IC impairment. HGS asymmetry (OR = 1.26, 95 % CI: 1.11–1.43) and weakness (OR = 2.09, 95 % CI: 1.78–2.45) were both independent risk factors for IC impairment. Notably, participants experiencing both HGS asymmetry and weakness were at even higher risk of IC impairment (OR = 2.47, 95 % CI: 1.99–3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between HGS status and impairments in specific IC domains, particularly in locomotion. In contrast to other domains, it was the Weakness only group, rather than the Both group, that had the highest risk of vitality impairment. There was a U-shaped relationship between HGS asymmetry and IC impairment.

Conclusions

HGS asymmetry and weakness were associated with an increased risk of composite and individual domain IC impairment. Assessing and maintaining HGS symmetry and strength may have implications for the early identification of individuals at risk for IC impairment and the prevention of related adverse health outcomes.

背景：内在能力（IC）下降显著影响老年人的健康结果。虽然握力弱（HGS）与IC损伤有关，但HGS不对称的作用尚不清楚，特别是在中国老年人群中。方法：我们纳入了2015年中国健康与退休纵向研究（CHARLS）中年龄≥60 岁的参与者。IC在认知、运动、心理、感觉和活力领域进行评估。用HGS的最大值测量不对称性和弱度。采用Logistic回归模型检验HGS不对称和虚弱的个体和组合分组与IC损伤的关系（五个领域的总分 ≥ 2）。利用限制三次样条（RCS）模型探讨了潜在的非线性关系。结果：纳入的4798名参与者(中位年龄66.0 岁，IQR 63.0-71.0 岁；56.9 %男性)，35.2% %有IC损伤。HGS不对称（OR = 1.26,95 % CI: 1.11-1.43）和虚弱（OR = 2.09,95 % CI: 1.78-2.45）均为IC损伤的独立危险因素。值得注意的是，同时经历HGS不对称和虚弱的参与者IC损伤的风险更高（OR = 2.47,95 % CI: 1.99-3.08），这表明对IC的复合影响。进一步的亚组分析显示HGS状态与特定IC领域的损伤之间存在显著关联，特别是在运动方面。与其他领域相比，只有虚弱组，而不是两者组，活力受损的风险最高。HGS不对称与IC损伤呈u型关系。结论：HGS不对称和薄弱与复合和单个区域IC损伤的风险增加有关。评估和维持HGS的对称性和强度可能对早期识别有IC损伤风险的个体和预防相关的不良健康结果具有重要意义。

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引用次数: 0

A descriptive analysis of sarcopenia markers in young adults with down syndrome 对患有唐氏综合症的年轻成人的肌肉疏松症指标进行描述性分析。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112655

Brett S. Nickerson , Michael R. Esco , George Schaefer , Elroy J. Aguiar , Stefan A. Czerwinski

Background

Most body composition research in individuals with Down Syndrome (DS) has focused on overweight and obesity. Although limited research has shown muscle mass indexes and physical performance levels of adults with DS are similar to or lower than older adults with sarcopenia, there is still a large gap in the literature regarding sarcopenia.

Objective

This brief report provides a comprehensive descriptive analysis of sarcopenia and obesity markers in individuals with DS.

Methods

Fourteen young adults (age = 26 ± 9 yrs.) with DS (males: n = 6; females: n = 8) had appendicular skeletal muscle mass (ASM) measured with bioimpedance analysis and handgrip strength (HGS) measured with a hand dynamometer (dominant hand). Sarcopenia was computed using the European Working Group on Sarcopenia in Older People revised definition (EWGSOP2).

Results

The BMI for the entire group was 24.41 ± 4.01 kg/m², ranging from 16.21 to 31.31 kg/m², with one participant classified as obese. ASM ranged from 11.33 to 24.41 kg (17.49 ± 4.71 kg), and 64 % of participants fell below the EWGSOP2 criteria for muscle mass. HGS ranged from 8 to 31 kg (20 ± 7 kg), and 57 % of participants fell below the EWGSOP2 criteria for muscular strength. Lastly, 5 of 14 participants (approximately 36 %) had sarcopenia according to the EWGSOP2 definition.

Conclusion

An alarming number of young adults with DS had sarcopenia, and low HGS and ASM when using the EWGSOP2 definition. Health professionals are encouraged to screen for sarcopenia in young adulthood rather than deferring it to a later stage in life for individuals with DS.

背景：大多数唐氏综合征（DS）个体的身体成分研究都集中在超重和肥胖上。虽然有限的研究表明，成人退行性椎体滑移患者的肌肉质量指数和体能水平与老年肌肉减少症患者相似或更低，但关于肌肉减少症的文献仍有很大的空白。目的：这份简短的报告提供了一个全面的描述性分析，肌肉减少症和肥胖的个体与DS。方法：青少年DS患者14例（年龄 = 26 ± 9 岁）(男： = 6；女性：n = 8)用生物阻抗分析测量了尾肢骨骼肌质量（ASM），用手测力仪（优势手）测量了握力（HGS）。肌少症的计算采用欧洲老年人肌少症工作组修订定义（EWGSOP2）。结果：全组BMI为24.41 ± 4.01 kg/m2，范围为16.21 ~ 31.31 kg/m2，其中1人属于肥胖。ASM范围从11.33到24.41 kg(17.49 ± 4.71 kg)， 64 %的参与者肌肉质量低于EWGSOP2标准。HGS范围为8至31 kg(20 ± 7 kg)， 57 %的参与者肌肉力量低于EWGSOP2标准。最后，根据EWGSOP2的定义，14名参与者中有5名（约36% %）患有肌肉减少症。结论：当使用EWGSOP2定义时，有相当数量的年轻DS患者存在肌肉减少症，且HGS和ASM较低。鼓励卫生专业人员在成年早期筛查肌肉减少症，而不是将其推迟到老年阶段。

{"title":"A descriptive analysis of sarcopenia markers in young adults with down syndrome","authors":"Brett S. Nickerson , Michael R. Esco , George Schaefer , Elroy J. Aguiar , Stefan A. Czerwinski","doi":"10.1016/j.exger.2024.112655","DOIUrl":"10.1016/j.exger.2024.112655","url":null,"abstract":"<div><h3>Background</h3><div>Most body composition research in individuals with Down Syndrome (DS) has focused on overweight and obesity. Although limited research has shown muscle mass indexes and physical performance levels of adults with DS are similar to or lower than older adults with sarcopenia, there is still a large gap in the literature regarding sarcopenia.</div></div><div><h3>Objective</h3><div>This brief report provides a comprehensive descriptive analysis of sarcopenia and obesity markers in individuals with DS.</div></div><div><h3>Methods</h3><div>Fourteen young adults (age = 26 ± 9 yrs.) with DS (males: <em>n</em> = 6; females: <em>n</em> = 8) had appendicular skeletal muscle mass (ASM) measured with bioimpedance analysis and handgrip strength (HGS) measured with a hand dynamometer (dominant hand). Sarcopenia was computed using the European Working Group on Sarcopenia in Older People revised definition (EWGSOP2).</div></div><div><h3>Results</h3><div>The BMI for the entire group was 24.41 ± 4.01 kg/m<sup>2</sup>, ranging from 16.21 to 31.31 kg/m<sup>2</sup>, with one participant classified as obese. ASM ranged from 11.33 to 24.41 kg (17.49 ± 4.71 kg), and 64 % of participants fell below the EWGSOP2 criteria for muscle mass. HGS ranged from 8 to 31 kg (20 ± 7 kg), and 57 % of participants fell below the EWGSOP2 criteria for muscular strength. Lastly, 5 of 14 participants (approximately 36 %) had sarcopenia according to the EWGSOP2 definition.</div></div><div><h3>Conclusion</h3><div>An alarming number of young adults with DS had sarcopenia, and low HGS and ASM when using the EWGSOP2 definition. Health professionals are encouraged to screen for sarcopenia in young adulthood rather than deferring it to a later stage in life for individuals with DS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112655"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor 揭示阻塞性睡眠呼吸暂停与骨关节炎之间的关系：多变量孟德尔随机分析凸显了体重指数作为混杂因素的作用。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112657

Xin Xu , Hui Yu , Mingyi Yang , Jiale Xie , Ke Xu , Erliang Li , Xianjie Wan , Jiachen Wang , Guoqiang Wang , Ying Pan , Peng Xu , Junfei Guo

Background

Osteoarthritis (OA) and obstructive sleep apnea (OSA) are prevalent chronic conditions with emerging evidence suggesting a potential link. However, the causality of this association remains unclear, possibly influenced by confounders like high body mass index (BMI). This study aimed to explore causal relationships between OA and OSA using Mendelian randomization (MR).

Methods

MR analysis was performed to assess causality between OA and OSA. Inverse variance weighting (IVW) was the primary MR method, complemented by sensitivity analyses, including MR steiger, MR-Egger, MR-PRESSO, weighted median, heterogeneity tests, and leave-one-out approaches to evaluate pleiotropy and confirm the robustness of the causal estimates. To exclude confounding effects of BMI, we also used a multivariate MR (MVMR).

Results

After adjusting for BMI through MVMR, no significant causal relationship was identified between genetically predicted OSA and OA phenotypes, including knee (KOA) and hip osteoarthritis (HOA), suggesting that obesity largely drives the observed relationship between these conditions. Similarly, MR steiger doesn't support a causal effect from OA on OSA. Sensitivity analyses confirmed the robustness of these results, with no significant evidence of horizontal pleiotropy or heterogeneity affecting outcomes. The findings indicate that BMI acts as a critical confounder in the relationship between OSA and OA, rather than OSA directly contributing to OA development.

Conclusions

Our findings indicate that there is no significant causal relationship between genetically predicted OSA and OA after adjusting for BMI. These findings underscore obesity as the primary shared risk factor, highlighting the importance of weight management as a key strategy for mitigating the risks of both conditions. Future research should aim to validate these findings in diverse populations and explore other metabolic pathways that may contribute to these complex associations.

背景：骨关节炎（OA）和阻塞性睡眠呼吸暂停（OSA）是常见的慢性疾病，越来越多的证据表明它们之间存在潜在的联系。然而，这种关联的因果关系尚不清楚，可能受到高体重指数（BMI）等混杂因素的影响。本研究旨在通过孟德尔随机化（MR）探讨OA和OSA之间的因果关系。方法：mri分析OA与OSA之间的因果关系。逆方差加权（IVW）是主要的MR方法，辅以敏感性分析，包括MR steiger、MR- egger、MR- presso、加权中位数、异质性检验和留一方法，以评估多效性并确认因果估计的稳健性。为了排除BMI的混杂影响，我们还使用了多变量磁共振（MVMR）。结果：在通过MVMR调整BMI后，没有发现遗传预测的OSA和OA表型（包括膝关节（KOA）和髋关节骨关节炎（HOA））之间存在显著的因果关系，这表明肥胖在很大程度上推动了这些疾病之间的关系。同样，steiger先生也不支持OA对OSA有因果关系。敏感性分析证实了这些结果的稳健性，没有显著的证据表明水平多效性或异质性影响结果。研究结果表明，在OSA和OA之间的关系中，BMI是一个关键的混杂因素，而不是OSA直接导致OA的发生。结论：我们的研究结果表明，在调整BMI后，基因预测的OSA和OA之间没有显著的因果关系。这些发现强调了肥胖是主要的共同风险因素，强调了体重管理作为减轻这两种疾病风险的关键策略的重要性。未来的研究应该致力于在不同的人群中验证这些发现，并探索可能导致这些复杂关联的其他代谢途径。

{"title":"Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor","authors":"Xin Xu , Hui Yu , Mingyi Yang , Jiale Xie , Ke Xu , Erliang Li , Xianjie Wan , Jiachen Wang , Guoqiang Wang , Ying Pan , Peng Xu , Junfei Guo","doi":"10.1016/j.exger.2024.112657","DOIUrl":"10.1016/j.exger.2024.112657","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) and obstructive sleep apnea (OSA) are prevalent chronic conditions with emerging evidence suggesting a potential link. However, the causality of this association remains unclear, possibly influenced by confounders like high body mass index (BMI). This study aimed to explore causal relationships between OA and OSA using Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>MR analysis was performed to assess causality between OA and OSA. Inverse variance weighting (IVW) was the primary MR method, complemented by sensitivity analyses, including MR steiger, MR-Egger, MR-PRESSO, weighted median, heterogeneity tests, and leave-one-out approaches to evaluate pleiotropy and confirm the robustness of the causal estimates. To exclude confounding effects of BMI, we also used a multivariate MR (MVMR).</div></div><div><h3>Results</h3><div>After adjusting for BMI through MVMR, no significant causal relationship was identified between genetically predicted OSA and OA phenotypes, including knee (KOA) and hip osteoarthritis (HOA), suggesting that obesity largely drives the observed relationship between these conditions. Similarly, MR steiger doesn't support a causal effect from OA on OSA. Sensitivity analyses confirmed the robustness of these results, with no significant evidence of horizontal pleiotropy or heterogeneity affecting outcomes. The findings indicate that BMI acts as a critical confounder in the relationship between OSA and OA, rather than OSA directly contributing to OA development.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that there is no significant causal relationship between genetically predicted OSA and OA after adjusting for BMI. These findings underscore obesity as the primary shared risk factor, highlighting the importance of weight management as a key strategy for mitigating the risks of both conditions. Future research should aim to validate these findings in diverse populations and explore other metabolic pathways that may contribute to these complex associations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112657"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma volume variations in response to high intensity interval training in obese women: The influential role of menopausal status and age 肥胖女性对高强度间歇训练的血浆容量变化：绝经状态和年龄的影响作用。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112664

Georges Jabbour , Maha Sellami , Horia-Daniel Iancu

Objective

This study aims to explore the effects of high-intensity interval training (HIIT) on plasma volume (PV) variations in obese women, with a focus on understanding how menopausal status and age influence these changes.

Methods

We enrolled fifty-nine obese women (perimenopausal and postmenopausal), aged approximately 56.6 years in a six-week HIIT program. Measurements of fitness, health, and PV were taken before and after the intervention. PV was assessed at two points during each session: at post-warm-up (PV1), and immediately post-training (PV2). These measurements were derived using hematocrit (Ht) and hemoglobin (Hb) values.

Results

The intervention led to notable reductions in anthropometric measures and blood pressure (P < 0.01). For all women pre- and post-HIIT comparisons revealed significant differences in the extent of PV reduction at all two points (P < 0.01). Multiple linear regression analysis revealed that age was a significant contributor to the decreases in plasma volume (PV) observed both after warm-up and following the supramaximal cycling test - SCT (r = 0.44 and r = 0.57). On the other hand, menopause status was an independent predictor for PV decreases after warm-up (r = 0.33) as well after SCT (r = 0.38). Following HIIT, only menopause status accounted for 19 % of the variation in PV decreases after warm-up and 21 % of the variation in PV decreases after SCT.

Conclusions

The findings suggest that HIIT is effective in enhancing plasma volume among obese menopausal women, attenuating the age-related decline in PV.

目的：本研究旨在探讨高强度间歇训练（HIIT）对肥胖女性血浆容量（PV）变化的影响，重点了解绝经状态和年龄如何影响这些变化。方法：我们招募了59名肥胖妇女（围绝经期和绝经后），年龄约为56.6 岁，参加了为期六周的HIIT计划。在干预前后测量健康、健康和PV。在每次训练中分别在两个时间点评估PV：热身后（PV1）和训练后（PV2）。这些测量是通过红细胞压积（Ht）和血红蛋白（Hb）值得出的。结果：干预导致人体测量值和血压显著降低（P ）结论：研究结果表明，HIIT可以有效提高肥胖绝经妇女的血浆容量，减缓与年龄相关的PV下降。

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引用次数: 0

Enhancing fracture risk indication: The impact of bone load index and muscle fat infiltration on vertebral compression fracture 加强骨折风险指示：骨负荷指数和肌肉脂肪浸润对椎体压缩性骨折的影响。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112654

Xiao-Yue Jiang , Zhi-Yang Tang , Bo-Wen Liu , Si-Yuan Lu , Dong-Gang Pan , Hui Jiang , Xiu-Hong Shan

Purpose

This study aims to identify risk factors for vertebral compression fracture and enhance the ability to indicate fracture risk.

Methods

A retrospective collection of clinical and imaging data was conducted for patients with vertebral compression fractures and control subjects who underwent quantitative computed tomography scans. Stepwise logistic regression analysis was employed to identify variables associated with fractures, constructing both unadjusted model and adjusted model.

Results

Compared with the non-fracture group, the fracture group showed significant differences in weight, body mass index (BMI), bone mineral density (BMD), vertebral cross-sectional area, paraspinal muscle area and right psoas major muscle fat area (all P < 0.05). Adjusted characteristics analyzed by stepwise logistic regression indicated that bone load index (BLI) (OR = 3.19, P = 0.041), paraspinal muscle fat infiltration (PMFI) (OR = 2.27, P = 0.039), and right psoas major muscle fat infiltration (RPMFI) (OR = 1.08, P = 0.005) were independent risk factors for vertebral fractures. Interaction analysis revealed a positive interaction between BLI and PMFI (OR = 1.95, P = 0.008) as well as RPMFI (OR = 1.53, P = 0.045). Compared with the unadjusted model, the diagnostic performance of the adjusted model was significantly improved (training set IDI: 19.5 %, validation set IDI: 18.4 %, P < 0.001). Correlation analysis demonstrated significant associations between BMD (r = −0.353, P = 0.002), BLI (r = 0.631, P < 0.001), PMFI (r = 0.412, P < 0.001), RPMFI (r = 0.513, P < 0.001), and the degree of vertebral compression.

Conclusion

Under conditions of bone maladaptive loading and muscle degeneration, vertebral bodies may become more susceptible to external forces, increasing the risk of vertebral compression fracture.

目的：本研究旨在确定椎体压缩性骨折的风险因素，并提高预测骨折风险的能力：方法：对接受定量计算机断层扫描的椎体压缩性骨折患者和对照受试者的临床和影像学数据进行回顾性收集。采用逐步逻辑回归分析法确定与骨折相关的变量，建立未调整模型和调整模型：结果：与非骨折组相比，骨折组在体重、体重指数（BMI）、骨质密度（BMD）、椎体横截面积、脊柱旁肌肉面积和右腰大肌脂肪面积等方面均存在显著差异（均为 P 结论：骨折组与非骨折组相比，在体重、体重指数（BMI）、骨质密度（BMD）、椎体横截面积、脊柱旁肌肉面积和右腰大肌脂肪面积等方面均存在显著差异：在骨不适应负荷和肌肉退化的情况下，椎体可能更容易受到外力的影响，从而增加椎体压缩性骨折的风险。

{"title":"Enhancing fracture risk indication: The impact of bone load index and muscle fat infiltration on vertebral compression fracture","authors":"Xiao-Yue Jiang , Zhi-Yang Tang , Bo-Wen Liu , Si-Yuan Lu , Dong-Gang Pan , Hui Jiang , Xiu-Hong Shan","doi":"10.1016/j.exger.2024.112654","DOIUrl":"10.1016/j.exger.2024.112654","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to identify risk factors for vertebral compression fracture and enhance the ability to indicate fracture risk.</div></div><div><h3>Methods</h3><div>A retrospective collection of clinical and imaging data was conducted for patients with vertebral compression fractures and control subjects who underwent quantitative computed tomography scans. Stepwise logistic regression analysis was employed to identify variables associated with fractures, constructing both unadjusted model and adjusted model.</div></div><div><h3>Results</h3><div>Compared with the non-fracture group, the fracture group showed significant differences in weight, body mass index (BMI), bone mineral density (BMD), vertebral cross-sectional area, paraspinal muscle area and right psoas major muscle fat area (all <em>P</em> < 0.05). Adjusted characteristics analyzed by stepwise logistic regression indicated that bone load index (BLI) (OR = 3.19, <em>P</em> = 0.041), paraspinal muscle fat infiltration (PMFI) (OR = 2.27, <em>P</em> = 0.039), and right psoas major muscle fat infiltration (RPMFI) (OR = 1.08, <em>P</em> = 0.005) were independent risk factors for vertebral fractures. Interaction analysis revealed a positive interaction between BLI and PMFI (OR = 1.95, <em>P</em> = 0.008) as well as RPMFI (OR = 1.53, <em>P</em> = 0.045). Compared with the unadjusted model, the diagnostic performance of the adjusted model was significantly improved (training set IDI: 19.5 %, validation set IDI: 18.4 %, <em>P</em> < 0.001). Correlation analysis demonstrated significant associations between BMD (<em>r</em> = −0.353, <em>P</em> = 0.002), BLI (<em>r</em> = 0.631, <em>P</em> < 0.001), PMFI (<em>r</em> = 0.412, P < 0.001), RPMFI (<em>r</em> = 0.513, P < 0.001), and the degree of vertebral compression.</div></div><div><h3>Conclusion</h3><div>Under conditions of bone maladaptive loading and muscle degeneration, vertebral bodies may become more susceptible to external forces, increasing the risk of vertebral compression fracture.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112654"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary inflammatory index and its associations with cardiovascular diseases and cancer: Evidence form NHANES 2017–2018 and Mendelian randomization analysis 膳食炎症指数及其与心血管疾病和癌症的关系：NHANES 2017-2018 和孟德尔随机分析的证据。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112665

Xuehua Wang , Qian Xu , Wenhu Liu, Jingjie Xiong, Han Li, Ni Xiong, Yan Wang, Zhaohui Wang

Objective

Cardiovascular diseases (CVDs) and cancer are significant global causes of mortality. However, the link between diets that promote inflammation and various subtypes of CVDs and cancers remains unclear.

Methods

Utilizing the dataset from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) data release cycle, our study encompassed 3538 adult participants within the age range of 20 to 80 years. The dietary questionnaire information was utilized to calculate dietary inflammatory index (DII) scores. Logistic regression analysis was employed to validate the association between the DII and CVDs, as well as overall cancer and special type cancer. Mediation analysis was conducted to evaluate the relationship between DII and the aforementioned diseases, with hemoglobin serving as the potential mediator. Mendelian randomization (MR) analysis externally validated hemoglobin's causal link to these diseases.

Results

Patients with the highest quartile levels of DII scores demonstrated an elevated prevalence of congestive heart failure (CHF), stroke, overall cancer and some specific types of cancers. The logistic regression analysis revealed a correlation between DII and CHF (OR = 1.197, p = 0.002), stroke (OR = 1.205, p < 0.001), as well as breast cancer (OR = 1.306, p = 0.004). The pro-inflammatory diet also resulted in lower hemoglobin levels (p < 0.001). Mediation analyses found a role for hemoglobin in the relationship of DII and CVDs.

Conclusions

Both CVDs and cancer risk were positively correlated with the DII in our study. Hemoglobin emerged as a potential mediator in the intricate relationship between DII and CHF, as well as stroke.

目的：心血管疾病（cvd）和癌症是全球重要的死亡原因。然而，促进炎症的饮食与各种心血管疾病亚型和癌症之间的联系尚不清楚。方法：利用2017-2018年国家健康与营养检查调查（NHANES）数据发布周期的数据集，我们的研究包括3538名年龄在20至80岁 之间的成人参与者。利用膳食调查问卷信息计算膳食炎症指数（DII）评分。采用Logistic回归分析验证DII与cvd、总体癌症与特殊类型癌症的相关性。通过中介分析来评估DII与上述疾病之间的关系，并将血红蛋白作为潜在的中介。孟德尔随机化（MR）分析从外部验证了血红蛋白与这些疾病的因果关系。结果：DII分数最高的患者表现出充血性心力衰竭（CHF）、中风、整体癌症和某些特定类型癌症的患病率升高。logistic回归分析显示DII与CHF （OR = 1.197,p = 0.002）、卒中（OR = 1.205,p ）相关。结论：在我们的研究中，心血管疾病和癌症风险与DII呈正相关。血红蛋白在DII和CHF以及中风之间的复杂关系中成为一个潜在的中介。

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引用次数: 0

Receiving financial support and its association with late-age depression: The mediating role of social engagement 接受经济支持及其与老年抑郁症的关系：社会参与的中介作用。

IF 3.9

Experimental gerontology

Pub Date : 2025-01-01 DOI: 10.1016/j.exger.2024.112647

Keying Song , Zijian Zhao , Amiya Saha , Jhumki Kundu

Objectives

Researchers have long been concerned with the association between family financial support and depression in older adults. However, it remains unclear whether social engagement influences the relationship between depression and financial support in later life. Therefore, this study aims to examine the relationship between receiving financial support from family and others and depression among Indian older adults and to also explore the mediating effect of social engagement on this relationship.

Subjects and methods

Data from the Longitudinal Aging Study in India Wave 1 (2017–2018) was used for the empirical analysis. A total sample of 30,210 older adults aged 60 years and above were selected for the study. The study employs bivariate and binary logistic regression analysis. Further Karlson–Holm–Breen method was adopted for mediation analysis.

Results

The adjusted prevalence of depression among older adults who did not receive financial support from family or others was nearly 33.8 % (men: 29.8 %, women: 37.4 %), compared to 29.9 % for those who received support (men: 27.6 %, women: 32 %). Older adults who received financial support had 21 % lower odds of depression (AoR: 0.79; 95 % CI: 0.73, 0.84) than those who did not. Additionally, the association between depression and receiving financial support was mediated by social engagement (17.3 %) with the mediating effect being higher among older women (29.3 %) than older men (13.5 %).

Conclusion

The study advances that although financial support plays a significant role in reducing depressive symptoms in older adults, social engagement also serves as an important mediator in this relationship. Enhancing opportunities for social engagement may amplify the protective effects of financial support, offering a more comprehensive approach to addressing mental health challenges among aging populations in India.

研究人员长期以来一直关注家庭经济支持与老年人抑郁之间的关系。然而，目前尚不清楚社会参与是否会影响晚年抑郁和经济支持之间的关系。因此，本研究旨在检视来自家庭和他人的经济支持与印度老年人抑郁之间的关系，并探讨社会参与在这一关系中的中介作用。对象与方法：采用2017-2018年印度第一波纵向老龄化研究数据进行实证分析。总共有30,210名年龄在60岁 以上的老年人被选为研究对象。本研究采用双变量和二元逻辑回归分析。进一步采用Karlson-Holm-Breen方法进行中介分析。结果：未获得家庭或他人经济支持的老年人抑郁症调整患病率接近33.8 %（男性：29.8 %，女性：37.4 %），而获得经济支持的老年人抑郁症调整患病率为29.9 %（男性：27.6 %，女性：32 %）。接受经济支持的老年人患抑郁症的几率降低21% % (AoR: 0.79；95 % CI: 0.73, 0.84)。此外，抑郁与获得经济支持之间的关联被社会参与介导（17.3 %），其中老年女性的中介效应（29.3 %）高于老年男性（13.5 %）。结论：经济支持在减轻老年人抑郁症状中起着重要作用，社会参与在这一关系中也起着重要的中介作用。增加社会参与的机会可以扩大财政支助的保护作用，为解决印度老龄化人口中的心理健康挑战提供更全面的办法。

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