Experimental gerontology最新文献

{"title":"Mechanism by which 24-week different-volume high-intensity interval training ameliorates renal fibrosis in naturally aging rats via regulating the TGF-β1/Smad pathway","authors":"Jiabao. Zhang ,&nbsp;Kaiyin. Cui ,&nbsp;Huiting. Wei ,&nbsp;Hao. Su","doi":"10.1016/j.exger.2025.112977","DOIUrl":"10.1016/j.exger.2025.112977","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of 24-week different-volume high-intensity interval training (HIIT) on renal fibrosis in naturally aging rats and to elucidate the underlying mechanisms based on the TGF-β1/Smad signaling pathway.</div></div><div><h3>Methods</h3><div>Forty 12-month-old male Wistar rats were randomly divided into a baseline control group (Group B, <em>n</em> = 10), a natural aging control group (Group C, <em>n</em> = 10), a high-volume HIIT group (Group H1, 25-min, n = 10), and a low-volume HIIT group (Group H2, 15-min, n = 10). Group B was sacrificed at the beginning of the experiment. Group C was fed without exercise for 24 weeks. Groups H1 and H2 underwent treadmill training with corresponding volumes (3 days/week for 24 weeks). An incremental volume test was conducted every 4 weeks to adjust exercise intensity. Body weight, blood, and urine indicators were monitored every 4 weeks. ELISA was used to measure 24-h urinary protein, serum creatinine, and creatinine clearance rate in each group. Body composition was monitored using DEXA every 8 weeks. After the intervention, renal tissues were collected. Pathological morphology and fibrosis degree were observed via HE and Masson staining. The gene and protein expression of TGF-β1, Smad2, Smad3, and p-Smad2/3 in the kidneys were detected using qPCR and Western blot.</div></div><div><h3>Results</h3><div>Compared with Group C, both HIIT groups effectively inhibited the age-related increase in body fat percentage and loss of lean body mass (<em>P</em> &lt; 0.05), significantly reduced 24-h urinary protein levels, maintained stable serum creatinine, and increased creatinine clearance rate (<em>P</em> &lt; 0.05). Histological results showed that renal pathological damage was reduced in both HIIT groups, and the collagen volume fraction (CVF) was significantly lower than in Group C (<em>P</em> &lt; 0.01). Molecular mechanism studies revealed that the expression of key molecules in the TGF-β1/Smad pathway was significantly higher in Group C than in Group B (<em>P</em> &lt; 0.05). In contrast, HIIT intervention significantly suppressed the activation of this pathway, with Group H1 showing more comprehensive effects in reducing the protein expression of TGF-β1, Smad2/3, and p-Smad2/3.</div></div><div><h3>Conclusion</h3><div>24-week HIIT intervention can effectively delay the decline of renal function and the progression of renal fibrosis in naturally aging rats. Its protective effect may be associated with inhibiting the overactivation of the TGF-β1/Smad signaling pathway. High-volume HIIT (H1) induced a more profound suppression of the pro-fibrotic pathway, whereas low-volume HIIT (H2) represents a time-efficient strategy conferring notable protection at the phenotypic level.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"212 ","pages":"Article 112977"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between the immune microenvironment and bone aging: From molecular mechanisms to therapeutic interventions","authors":"Jianxu Wang ,&nbsp;Yijun Xin ,&nbsp;Zihao Dong ,&nbsp;Siying Li ,&nbsp;Guang Yang","doi":"10.1016/j.exger.2025.112974","DOIUrl":"10.1016/j.exger.2025.112974","url":null,"abstract":"<div><div>The core mechanism of skeletal aging lies in the comprehensive disruption of microenvironmental homeostasis, involving a multidimensional interactive network comprising immune cells, mesenchymal stem cells, and their differentiated lineages. Although osteoporosis (OP) and osteoarthritis (OA) have traditionally been viewed as distinct degenerative disorders, recent breakthroughs in osteoimmunology reveal their shared immune-aging mechanism: immune cell dysfunction within the bone marrow microenvironment triggers inflammaging, subsequently driving a vicious cycle of bone formation and resorption through the senescence-associated secretory phenotype (SASP). This review not only integrates the molecular landscape of osteoclast-osteoblast-immune triangular crosstalk but also highlights emerging mechanisms such as mitochondrial dysfunction, exosomal communication, and cell death mechanisms, systematically establishing the pivotal role of the immune microenvironment in bone aging and providing a theoretical framework for developing next-generation targeted therapies against skeletal aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"212 ","pages":"Article 112974"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring how exercise frequency impacts muscle strength and balance in institutionalized older adults: Protocol for a randomized controlled trial","authors":"Filipe Rodrigues ,&nbsp;Bernardo Pereira ,&nbsp;Elisabete Silva ,&nbsp;Diogo Monteiro ,&nbsp;Raul Antunes","doi":"10.1016/j.exger.2025.112985","DOIUrl":"10.1016/j.exger.2025.112985","url":null,"abstract":"<div><div>This protocol for a randomized controlled trial aims to evaluate the impact of exercise frequency on muscle strength, balance, and fall risk among institutionalized older adults. Recognizing the unique physical and functional limitations of this population, the study will test whether two or three weekly sessions of multicomponent exercise yield differential outcomes. Sixty participants residing in nursing homes will be randomly assigned to one of two groups: a control group performing exercise twice weekly and an experimental group training three times weekly, over a 12-week intervention period. All sessions will follow international guidelines for older adults, incorporating aerobic, strength, balance, and flexibility training at light-to-moderate intensity. Primary outcomes include lower- and upper-body strength and dynamic balance; secondary outcomes comprise waist circumference, body mass index, and fall incidence. The program is designed with progressive adaptation and safety in mind, employing the Talk Test to regulate intensity and standardized measures to monitor physiological responses. The rationale stems from the gap in existing literature regarding optimal exercise frequency for institutionalized populations. While two sessions per week have been associated with functional improvements, it remains unclear whether an additional weekly session provides significant incremental benefits. By isolating frequency as the primary variable, the trial addresses the need to define the minimum effective dose of structured exercise for enhancing physical activity, functional capacity, and reducing fall risk. Results are expected to inform tailored physical activity guidelines and implementation strategies in long-term care settings, balancing clinical efficacy with feasibility and safety constraints typical of institutional environments.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112985"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial of wearable accelerometer-based feedback and behavior change techniques to increase physical activity and reduce sedentary behavior in older women","authors":"Yu-Huei Wang ,&nbsp;Ting-Fu Lai ,&nbsp;Yung Liao ,&nbsp;I-Lun Cheng ,&nbsp;Ming-Chun Hsueh","doi":"10.1016/j.exger.2025.112979","DOIUrl":"10.1016/j.exger.2025.112979","url":null,"abstract":"<div><h3>Purpose</h3><div>Effective strategies are needed to address declining physical activity (PA) and prolonged sedentary behavior (SB) in older women. This study examined the impact of accelerometer-based feedback and behavior change technique (BCTs) interventions on PA and SB patterns.</div></div><div><h3>Methods</h3><div>42 healthy older women (mean age = 72.6 ± 5.2 years) were randomly assigned to an intervention group (<em>n</em> = 22) or a control group (<em>n</em> = 20). The intervention group received real-time activity feedback via a wearable device and a 12-week BCTs intervention, including PA and SB education, exercise consultation, movement notifications, and goal setting. The control group maintained their usual lifestyle and wore an accelerometer without feedback. PA (step count, light-to-vigorous intensity) and SB (total sedentary time, frequency and total duration ≥30-min sedentary bouts, and sedentary breaks) were assessed using the ActiGraph wGT3X-BT.</div></div><div><h3>Results</h3><div>After 12 weeks, the intervention group showed significant improvements in total PA (<em>p</em> = .000; ⴄ² = 0.450), daily step count (<em>p</em> = .011; ⴄ² = 0.161),≥30-min sedentary bouts frequency (<em>p</em> = .000; ⴄ² = 0.524), and total duration in &gt;30-min sedentary bouts (p = .000; ⴄ² = 0.513). No significant changes were found in specific-intensity PA, total sedentary time, and sedentary breaks.</div></div><div><h3>Conclusion</h3><div>Wearable feedback and BCT interventions effectively increased PA and reduced prolonged SB in older women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112979"},"PeriodicalIF":4.3,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association and potential mediators between obstructive sleep apnea and diabetic nephropathy: A Mendelian randomization study","authors":"Yonghang He ,&nbsp;Junxiang Wang ,&nbsp;Yun Wen ,&nbsp;Bo Yi ,&nbsp;Yong Wang","doi":"10.1016/j.exger.2025.112980","DOIUrl":"10.1016/j.exger.2025.112980","url":null,"abstract":"<div><h3>Background</h3><div>Previous observational studies have reported the association between obstructive sleep apnea (OSA) and diabetic nephropathy. However, it remains to be confirmed whether this association is causal. This study aimed to investigate the causal association of OSA with diabetic nephropathy and the mediating effect of common risk factors using Mendelian randomization (MR) design.</div></div><div><h3>Method</h3><div>The study data were sourced from genome-wide association studies (GWAS). Bidirectional two-sample MR and multivariable MR analyses were conducted to assess causal relationships between OSA and diabetic nephropathy. Potential mediation by common risk factors was evaluated through two-step MR. In addition, the MR results were supported by various sensitivity and validation analyses.</div></div><div><h3>Results</h3><div>We presented genetic evidence that OSA could unidirectionally increase the risk of diabetic nephropathy (OR = 1.30; 95 % CI: 1.13, 1.50; <em>p</em> = 2.51 × 10⁻⁴). After adjusting for BMI, high blood pressure, blood glucose levels, glycated hemoglobin levels, severe insulin resistance, years of schooling, nap during day, processed meat consumption, and coffee intake, the causal effect of OSA on diabetic nephropathy remained statistically significant. Further mediation MR analysis showed that BMI and high blood pressure may mediate the causal relationship between OSA and diabetic nephropathy, with a mediation effect of 26.35 % and 9.91 %, respectively.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that genetically predicted OSA is associated with a higher risk of diabetic nephropathy. Additionally, BMI and high blood pressure are involved in the mechanism of OSA-induced diabetic nephropathy.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112980"},"PeriodicalIF":4.3,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sensory afferences in postural control quantified by force platform in healthy older adults: Systematic review and meta-analysis","authors":"J. Aflalo ,&nbsp;C. Truong ,&nbsp;A. Nicolaï ,&nbsp;L. Gouzer ,&nbsp;B. Morisset ,&nbsp;F. Bertin-Hugault ,&nbsp;D. Ricard ,&nbsp;F. Quijoux","doi":"10.1016/j.exger.2025.112976","DOIUrl":"10.1016/j.exger.2025.112976","url":null,"abstract":"<div><div>Postural balance in older adults is a key research focus, as impaired balance significantly increases fall risk, potentially leading to severe injury or mortality. Given age-related sensory decline, force-platform posturography assessing sensory perturbation effects could elucidate postural control deficits in aging. This systematic review and meta-analysis examines older adults' ability to maintain quiet stance during sensory perturbations.</div><div>We searched 8 databases for studies evaluating older adults' balance under various sensory conditions.</div><div>We included 64 articles in this review, for a total number of 4481 subjects. Proprioceptive and visual afferences were the most explored. Meta-analyses were conducted when several studies shared similar procedures and domain analysis for older adults (OA), older fallers (OF), and young adults (YA). They showed a significant impact of visual deprivation on older adults' balance for positional, dynamic and frequential variables, while it was significant only in the positional and dynamic domains for younger adults. When proprioception was disturbed, all the meta-analyses showed a significant impact on older adults.</div><div>We concluded that positional and dynamic variables are sensitive to sensory perturbations and therefore could be useful in geriatric balance assessment. However, we emphasize the variability in methodological approaches and reporting standards, which constrains the broader applicability of these findings. We posit that posturographic research requires standardization and the establishment of an expert consensus regarding clinically relevant variables to facilitate the integration of posturography into geriatric fall risk assessment protocols, preventive programs and rehabilitation care.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112976"},"PeriodicalIF":4.3,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145610421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less habitual knee-bent sitting and more lying time are associated with worse frailty, mobility and balance in long-term care residents","authors":"Madeline E. Shivgulam ,&nbsp;Emily E. MacDonald ,&nbsp;Jocelyn Waghorn ,&nbsp;Chris Cartwright ,&nbsp;Andrea Mayo ,&nbsp;Derek S. Kimmerly ,&nbsp;Kenneth Rockwood ,&nbsp;Olga Theou ,&nbsp;Myles W. O'Brien","doi":"10.1016/j.exger.2025.112971","DOIUrl":"10.1016/j.exger.2025.112971","url":null,"abstract":"<div><div>The impact of habitual postures on frailty, and balance, mobility, and transfer ability, particularly among people in long-term care. We sought to characterize the time spent in detailed postures and the relationships they have with frailty and Hierarchical Assessment of Balance and Mobility (HABAM) among older adults living in long-term care. Forty-four moderate-to-severely frail long-term care residents were recruited (36 females; age: 83 ± 10 years; body mass index: 31.8 ± 7.6 kg/m²). Participants wore an activPAL on their torso, thigh, and shin for 3.6 ± 0.5 days. Frailty was determined via a 65-item index and Clinical Frailty Scale (CFS). Functional abilities were measured using the HABAM. Linear regressions, adjusted for age and body mass index, demonstrated that higher frequency of sit-to-stand transitions (18 ± 23 transitions/day), standing time (52 ± 87 min/day) and step counts (442 ± 945 steps/day) were associated with lower frailty (frailty index: 0.438 ± 0.115) and higher HABAM scores (23.2 ± 16.3/67.0; all, <em>p</em> ≤ 0.034). Knee-bent sitting (142 ± 228 min/day) was associated with higher HABAM and lower frailty index scores (both, <em>p</em> ≤ 0.002). More non-upright time (1337 ± 133 min/day) and lying time (1138 ± 372 min/day) were associated with worse frailty index and HABAM scores (all, <em>p</em> ≤ 0.021). There were no associations between straight-legged sitting (56 ± 227 min/day) with frailty index or HABAM scores (both, <em>p</em> ≥ 0.219). Overall, participant posture was mostly characterized by a horizontal thigh (sitting or lying), with ∼1 h/day upright. Intervention models promoting upright time, sit-to-stand transitions, and knee-bent sitting rather than lying are warranted for frailty and HABAM management.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112971"},"PeriodicalIF":4.3,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving intrinsic capacity in midlife women: A mixed-methods study of a personalized multicomponent intervention aligned with the WHO ICOPE framework","authors":"Ruby Yu ,&nbsp;Cecilia Tong ,&nbsp;Matthew Yu ,&nbsp;Florence Ho ,&nbsp;Angel Hui ,&nbsp;Emily Lui ,&nbsp;Jean Woo","doi":"10.1016/j.exger.2025.112973","DOIUrl":"10.1016/j.exger.2025.112973","url":null,"abstract":"<div><h3>Background</h3><div>Intrinsic capacity (IC) preservation during midlife represents a critical yet overlooked opportunity for preventing age-related functional decline. We developed <em>WomenWellness</em>, a 12-week personalized multicomponent intervention aligned with the WHO Integrated Care for Older People (ICOPE) framework, and evaluated its effectiveness and scalability potential.</div></div><div><h3>Methods</h3><div>In a multicentre randomized controlled trial conducted in Hong Kong, we enrolled 176 women with ≥1 IC domain impairment, randomizing them to <em>WomenWellness</em> (n = 117) or to a control group that received a health kit containing educational materials and lifestyle tips (n = 59). The intervention integrated personalized care, multimodal exercise, and cognitive-psychosocial activities. Outcomes included IC composite scores (range 0-6, higher = worse), domain-specific impairments, anthropometrics, physical and cognitive performance, urinary incontinence prevalence, and pain severity, analysed using generalized linear mixed models adjusted for age, education, and medication use. A parallel qualitative evaluation involved 14 focus groups (8 participant groups, 6 service provider groups) exploring intervention acceptability, feasibility, and scalability through thematic analysis.</div></div><div><h3>Results</h3><div>Participants (mean age 61.5 ± 3.6 years) receiving <em>WomenWellness</em> showed significantly greater reductions in IC composite scores than controls (β = 0.39, 95 % CI = 0.03-0.75, p = .032), with domain-specific benefits including reduced chair stand times (β = 1.57, 95 % CI = 0.51-2.63, p = .004), ASMI preservation (β = −0.32, 95 % CI = −0.60-−0.04, p = .027), cardiorespiratory fitness gains (β = −11.47, 95 % CI = −16.89-−6.04, p &lt; .001), lower malnutrition risk (OR = 0.26, 95 % CI = 0.08-0.84, p = .025), and reduced visual impairment (OR = 0.28, 95 % CI = 0.12–0.65, p = .003). Qualitative findings revealed high acceptability, with participants valuing the integrated approach and service providers emphasizing its adaptability to community settings.</div></div><div><h3>Conclusion</h3><div><em>WomenWellness</em> effectively enhanced IC in midlife women, demonstrating high acceptability, feasibility, and adaptive fidelity, thereby supporting the integration of such programs into routine midlife healthcare services.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112973"},"PeriodicalIF":4.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia","authors":"Shota Uebo ,&nbsp;Yoshiyuki Ikeda ,&nbsp;Yoshihiro Uchikado ,&nbsp;Yuichi Sasaki ,&nbsp;Yuichi Akasaki ,&nbsp;Takuro Kubozono ,&nbsp;Mitsuru Ohishi","doi":"10.1016/j.exger.2025.112970","DOIUrl":"10.1016/j.exger.2025.112970","url":null,"abstract":"<div><div>Aim</div><div>Sarcopenia, a major cause of frailty in postmenopausal women, is linked to mitochondrial dysfunction, but the underlying mechanisms remain unclear. This study aimed to clarify whether mitophagy, a mitochondrial quality control mechanism, contributes to postmenopausal sarcopenia, to elucidate its underlying mechanism, and to assess whether it can be rescued.</div></div><div><h3>Methods</h3><div>C57BL/6 mice (12-week-old females) underwent ovariectomy to establish a menopause mouse model, or sham surgery, and the therapeutic effects of nicotinamide mononucleotide (NMN) were assessed. Human skeletal muscle myoblasts (HSMMs) differentiated under postmenopausal conditions with or without 17β-estradiol (E2), and Rab9 expression was modulated using CRISPR activation.</div></div><div><h3>Results</h3><div>Ovariectomized mice exhibited decreased muscle mass and strength. E2 deficiency in HSMMs inhibited skeletal muscle cell differentiation, promoted senescence, impaired mitochondrial function, and reduced mitophagy. However, E2 deficiency did not modulate light chain 3 and autophagy-related 7 but reduced Rab9 expression and the colocalization of Rab9 with lysosomal-associated membrane protein 2, suggesting that E2 mediates mitophagy through Rab9-dependent alternative autophagy. Furthermore, overexpression of Rab9 in E2-deficient HSMMs enhanced mitophagy, improved mitochondrial function, suppressed cellular senescence, and promoted skeletal muscle cell differentiation. The administration of NMN to ovariectomized mice increased Rab9 expression and improved sarcopenia through increased mitophagy.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that estrogen deficiency impairs mitophagy originated from Rab9-dependent alternative autophagy, leading to mitochondrial dysfunction and sarcopenia, while enhancement of Rab9 restores mitochondrial quality control and muscle function. These results identify Rab9-dependent mitophagy as a potential therapeutic target for postmenopausal sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112970"},"PeriodicalIF":4.3,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum uric acid and frailty: Evidence from NHANES database and perioperative geriatric frailty cohort","authors":"Jirun Wang ,&nbsp;Yaqi Han ,&nbsp;Yan Xin ,&nbsp;Yang Zhao ,&nbsp;Lei Zhang ,&nbsp;Peipei Shan ,&nbsp;Wei Feng ,&nbsp;Youzhuang Zhu","doi":"10.1016/j.exger.2025.112969","DOIUrl":"10.1016/j.exger.2025.112969","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a common syndrome among older adults, increasing vulnerability to adverse outcomes. Serum uric acid (SUA) has been associated with several aging-related diseases, but its relationship with frailty remains inconclusive.</div></div><div><h3>Methods</h3><div>We performed an analysis using data from the NHANES (2003–2016) and a cohort study of perioperative geriatric frailty. Multivariable logistic regression and restricted cubic spline analysis were used to examine the association between SUA and frailty. Subgroup analyses and interaction were also conducted. Sensitivity analysis was conducted to evaluate the robustness of the results.</div></div><div><h3>Results</h3><div>Among 24,183 NHANES participants, 16.2 % were frail. The cohort study included 149 participants, with 57.0 % developed frailty post-surgery. Higher SUA levels were significantly associated with frailty in both populations [NHANES: adjusted OR (aOR): 1.14, 95 % CI: 1.09–1.20; <em>p</em> &lt; 0.001; Cohort: aOR: 1.49, 95 % CI: 1.04–1.91; <em>p</em> = 0.025]. Restricted cubic spline regression revealed a U-shaped relationship between SUA and frailty, with OR lowest at 4.3 mg/dL. The association between SUA and frailty was significantly stronger in females than in males (adjusted OR: 1.24; 95 % CI: 1.16–1.32). Sensitivity analysis confirmed the robustness of the association between SUA and frailty (aOR: 1.17; 95 % CI: 1.11–1.23).</div></div><div><h3>Conclusions</h3><div>SUA is significantly associated with frailty in both community and surgical populations. In community population, a U-shaped relationship was observed, whereas only high SUA levels predict frailty perioperatively. Females are more susceptible to SUA-related frailty.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"212 ","pages":"Article 112969"},"PeriodicalIF":4.3,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}