Experimental gerontology最新文献

{"title":"Association of grip indicators with post-discharge recovery in geriatric and hip fracture inpatients","authors":"Myrthe Swart ,&nbsp;Merle Geerds ,&nbsp;Ivan Bautmans ,&nbsp;Liza De Dobbeleer ,&nbsp;Siddharta Lieten ,&nbsp;Hugo Plácido da Silva ,&nbsp;Rudi Tielemans ,&nbsp;Cindel Bonneux ,&nbsp;Yvonne Schoon ,&nbsp;Geeske Peeters ,&nbsp;Marcel Olde Rikkert ,&nbsp;Dieuwke van Dartel ,&nbsp;René Melis","doi":"10.1016/j.exger.2025.113014","DOIUrl":"10.1016/j.exger.2025.113014","url":null,"abstract":"<div><h3>Objectives</h3><div>Hand grip measures offer potential indicators for recovery after hospitalization in older adults. We investigated prospective associations of the grip indicators maximal grip strength (GSmax), fatigue resistance (FR) and grip work (GW) with post-discharge functional limitations, health-related quality of life (HRQOL) and survival in older inpatients.</div></div><div><h3>Methods</h3><div>Grip indicators were evaluated at admission in general geriatric inpatients (GGI, <em>n</em> = 149) and geriatric hip fracture inpatients (HIP, <em>n</em> = 109). Questionnaires on functional limitations (10–40, lower is better) were collected for two weeks pre-admission, admission, three months follow-up, and six months follow-up. HRQOL (−4–10, higher is better) was assessed at admission, three months follow-up and six months follow-up. With individual growth modeling, we established the associations between grip indicators and the outcome trajectories. Three-month survival was analyzed using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>In GGI, higher FR and GW were associated with better functional recovery from admission to three months follow-up (FR: B = −1.0 points per 10s increase, 95 %CI −1.9, −0.14; GW: B = −0.33 points per 100 kPa × s increase, 95 %CI −0.59, −0.07). HIP with higher grip indicators showed a better functional recovery towards three months follow-up (GSmax: B = −2.4 per 10 kPa increase, 95 %CI −3.9, −0.89; FR: B = −1.1, 95 %CI −2.4, 0.20; GW: B = −0.31, 95 %CI −0.61, −0.02). No or weak associations were found between grip indicators and HRQOL recovery. Hazard ratios pointed towards a better survival for better scores on grip indicators, but associations were not statistically significant.</div></div><div><h3>Conclusion</h3><div>Higher FR and GW at admission were associated with better recovery post-discharge in geriatric inpatients. Future research should examine the added clinical value of grip indicators in addition to known patient characteristics.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113014"},"PeriodicalIF":4.3,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice","authors":"Qi Si ,&nbsp;Lin Wu ,&nbsp;Ximei Zhang ,&nbsp;Guangyao Shi ,&nbsp;Yingying Zhao ,&nbsp;Yong Liu ,&nbsp;Baoshun Hao ,&nbsp;Shujie Yu ,&nbsp;Bin Zhou ,&nbsp;Yanling Zhang ,&nbsp;Xiaoxian Qian ,&nbsp;Dinghui Liu ,&nbsp;Jianrui Zheng","doi":"10.1016/j.exger.2025.113011","DOIUrl":"10.1016/j.exger.2025.113011","url":null,"abstract":"<div><h3>Objective</h3><div>Vascular aging is a critical risk factor for the development and progression of cardiovascular diseases. Age-related degenerative changes in vascular structure and function significantly promote the onset of various vascular disorders. Currently, the specific molecular mechanisms underlying age-associated vascular structural and functional decline have not been fully elucidated. Ginsenoside Rb1 (Rb1), as the primary active component of ginseng, has been confirmed to possess potential anti-aging properties. This study aims to investigate the protective effects of Rb1 on the aorta in aged mice and its underlying molecular mechanisms, thereby providing experimental evidence and theoretical support for the screening of natural anti-vascular aging drugs.</div></div><div><h3>Methods</h3><div>Naturally aged (72-week-old) male C57BL/6J mice were randomly divided into two groups (<em>n</em> = 5 per group) to receive intraperitoneal injections of either PBS (Old group) or 20 mg/kg Rb1 (Old + Rb1 group) for 6 weeks. Young mice (12-week-old, n = 5) served as controls. Aortic tissues were analyzed using histomorphology (hematoxylin and eosin, H&amp;E), nanoscale biomechanics (Atomic Force Microscopy, AFM), senescence biomarkers (P21 immunofluorescence, SA-β-gal staining), apoptosis (TUNEL assay), and DNA damage (γ-H2AX).</div></div><div><h3>Results</h3><div>Compared to the Old group, Rb1 significantly alleviated structural remodeling of the aging aorta, restoring smooth muscle cell alignment and extracellular matrix. AFM analysis showed that Rb1 ameliorated the aging-induced impairments in nanobiomechanical properties (including elasticity, viscosity, and surface topography) induced by aging. Furthermore, Rb1 treatment downregulated the expression of P21 in the aorta, reduced the positive area percentage of SA-β-gal positivity, and decreased the proportion of TUNEL-positive apoptotic cells, although none of these indicators were comparable to the levels observed in the Young control group. Notably, Rb1 significantly alleviates the elevation of γ-H2AX (a marker of DNA double-strand breaks) in the aging aorta.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that Rb1 attenuates DNA damage, thus ameliorating structural remodeling and biomechanical function of the aging aorta, and delaying vascular aging and apoptosis. Our findings suggest that Rb1 counteracts age-related aortic impairment, potentially by targeting the DNA damage pathway, which highlights its therapeutic potential against vascular aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113011"},"PeriodicalIF":4.3,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between changes in intrinsic capacity of older adults in Chinese communities and adverse health-related outcomes: A prospective longitudinal Cohort study","authors":"Yaru Zhou ,&nbsp;Wenhua Yu ,&nbsp;Xiaohong Liu","doi":"10.1016/j.exger.2025.113008","DOIUrl":"10.1016/j.exger.2025.113008","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Preserving intrinsic capacity (IC) is essential for healthy aging. This study examined the associations between longitudinal changes in IC and subsequent adverse health outcomes.</div></div><div><h3>Methods</h3><div>Participants were community-dwelling adults aged ≥60 years from the China Health and Retirement Longitudinal Study (CHARLS). Changes in IC between 2011 and 2013 were classified as consistently well, improved, worsened, or consistently declined. Logistic regression assessed associations with falls and hospitalization (2015), and Cox models evaluated all-cause mortality (2020).</div></div><div><h3>Results</h3><div>Changes in IC were significant predictors of adverse outcomes. Worsened (OR = 1.674, 95 % CI: 1.163–2.411, <em>P</em> = 0.006) and consistently declined changes in IC (OR = 1.914, 95 % CI: 1.373–2.668, <em>P</em> &lt; 0.001) were both associated with an increased risk of falls, while domain-specific changes, such as worsened locomotion, consistently declined in cognition and fluctuations in psychology or vision, were also linked to increased fall risk (all <em>P</em> &lt; 0.017). Both consistently declined IC (OR = 1.513, 95 % CI: 1.079–2.122, P &lt; 0.017) and worsened locomotion were independent predictors of hospitalization (OR = 1.837, 95 % CI: 1.265–2.670, <em>P</em> = 0.001). Declines in locomotion were also strongly associated with mortality, with higher risk observed in the worsened group (HR = 1.571, 95 % CI: 1.088–2.267, <em>P</em> &lt; 0.017).</div></div><div><h3>Conclusions</h3><div>Monitoring intrinsic capacity changes, especially locomotion decline, enables early identification of vulnerable older adults and supports timely, targeted interventions to reduce adverse outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113008"},"PeriodicalIF":4.3,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling the overlap between frailty and intrinsic capacity in older adults","authors":"Yuwei Qi ,&nbsp;Natasja M. van Schoor ,&nbsp;Laura A. Schaap ,&nbsp;Emiel O. Hoogendijk","doi":"10.1016/j.exger.2025.113006","DOIUrl":"10.1016/j.exger.2025.113006","url":null,"abstract":"<div><h3>Introduction</h3><div>It has been suggested that two prominent frameworks in geriatrics, frailty and intrinsic capacity (IC), represent two opposite ends of the same continuum. Frailty quantifies accumulated deficits and vulnerability, and IC measures an individual's capacities and functional reserves. This study investigates the overlap between frailty and IC in a large cohort of older adults.</div></div><div><h3>Methods</h3><div>We analysed 3246 participants aged 55+ from the Longitudinal Aging Study Amsterdam. Participants were categorised into four groups: neither frail nor low IC, low IC only, frail only, and both frail and low IC. Overlap was examined across age groups. Domain scores (vitality, sensory, cognition, psychology, locomotion) were compared between groups.</div></div><div><h3>Results</h3><div>Among 57–59 year olds, only 2.2 % were both frail and had low IC. This proportion increased with age, reaching 53.6 % at ages 87–89, while the “frail only” and “low IC only” groups declined. Overlap between frailty and domain scores showed that the “Neither” group consistently had the highest IC scores across all five domains, while the “Both” group consistently had the lowest scores.</div></div><div><h3>Conclusions</h3><div>In later life, being frail does not necessarily imply low IC, and vice versa. Frailty and low IC identify different groups in early older age, but the overlap between them becomes more pronounced with increasing age. Comprehensive assessment of ageing therefore requires measures that capture both vulnerability to decline and capacity.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113006"},"PeriodicalIF":4.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between C-reactive protein-triglyceride glucose index and risk of sarcopenia in older adults: findings from CHARLS and NHANES","authors":"Yan Chen ,&nbsp;Tianchong Huang ,&nbsp;Jiayin Wang ,&nbsp;Changsheng Guo ,&nbsp;Jing Gao ,&nbsp;Xiaodong Feng","doi":"10.1016/j.exger.2025.113003","DOIUrl":"10.1016/j.exger.2025.113003","url":null,"abstract":"<div><h3>Background</h3><div>Insulin resistance (IR) and inflammation are two crucial risk factors of sarcopenia. C-reactive protein-triglyceride glucose index (CTI) has been proposed to be a novel biomarker reflecting IR and inflammation. However, association between CTI and sarcopenia risk remains unclear.</div></div><div><h3>Aim</h3><div>To explore the association between CTI and sarcopenia risk.</div></div><div><h3>Methods</h3><div>Data were obtained from Nutrition Examination Survey (NHANES) 2001–2010 and China Health and Retirement Longitudinal Study (CHARLS) 2011–2015. NHANES was used for cross-sectional analysis, and weighted logistic regression analysis was conducted to explore association between CTI and sarcopenia. CHARLS was used for longitudinal analysis, and the primary endpoint was the first occurrence of sarcopenia over follow-up. Logistic regression analysis and Cox proportional hazard analysis were conducted to explore the relationship between CTI and the risk of sarcopenia. Restricted cubic spline (RCS) analysis was performed to investigate the non-linear association between CTI and sarcopenia risk, and receiver operating characteristics (ROC) curves and the area under the ROC curve (AUC) were utilized to assess the predictive capability of CTI on the risk of sarcopenia.</div></div><div><h3>Results</h3><div>A total of 11,286 Americans and 1478 Chinese aged ≥60 years were included in this study. Logistic and Cox regression analysis revealed the cross-sectional (OR: 1.52, 95 %CI: 1.15–1.99, <em>P</em> = 0.004) and longitudinal (HR: 1.35, 95 %CI: 1.10–1.65, P = 0.004) correlation between CTI and sarcopenia risk after adjusting the covariates. For the two databases, non-linear association between CTI and sarcopenia risk was observed (P for non-linear &lt;0.001). Additionally, compared to CRP and the TyG index, CTI exhibited the best predictive capability for sarcopenia risk, with the highest AUC (CHARLS: 0.730, NHANES: 0.722).</div></div><div><h3>Conclusion</h3><div>There exist both the cross-sectional and longitudinal association between CTI level and sarcopenia risk in older adults, and it is crucial to monitor CTI in the prevention and treatment of sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113003"},"PeriodicalIF":4.3,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent musculoskeletal pain and subsequent falls in China: Evidence from CHARLS with exploratory frailty mediation analyses","authors":"Ruizheng Zhu ,&nbsp;Guangjun Tang ,&nbsp;Manhong Yang ,&nbsp;Junde Wu ,&nbsp;Zhaojun Chen","doi":"10.1016/j.exger.2025.113005","DOIUrl":"10.1016/j.exger.2025.113005","url":null,"abstract":"<div><h3>Background</h3><div>Musculoskeletal pain (MSP) is prevalent among middle-aged and older adults and may increase fall risk through functional decline, but evidence on pain persistence and the potential role of frailty in China remains limited.</div></div><div><h3>Methods</h3><div>This study utilized data from the 2011 and 2015 China Health and Retirement Longitudinal Study (CHARLS), involving 13,057 participants in 2011 and a cohort of 7390 who reported no falls in 2011 and completed the 2015 follow-up. Among them, 1046 had persistent MSP identified using standardized CHARLS pain items. Participants indicated body pain locations, with MSP noted if pain was present anywhere. Baseline MSP was recorded in 2011, and persistent MSP was reported in both 2011 and 2015. Falls were self-reported. Survey-weighted logistic regression analyzed associations, while mediation analyses used baseline MSP (2011) as exposure and frailty in 2015 as a mediator, employing a counterfactual framework to decompose effects, interpreted cautiously due to standard assumptions and a two-year fall recall window. Baseline characteristics were compared between included and excluded participants to evaluate potential selection bias.</div></div><div><h3>Results</h3><div>In the longitudinal cohort, 1072 incident falls were recorded, with a higher fall rate among participants with persistent MSP than among those without (25.69 % vs 12.48 %). Adjusted models showed baseline MSP increased fall risk (OR 1.36, 95 % CI 1.15–1.60), with a stronger link for persistent MSP (OR 2.08, 95 % CI 1.70–2.54). Similar trends were observed for multisite pain. Mediation analysis indicated frailty partially mediated the effect of baseline MSP on falls, accounting for about 29 % of the effect, though results were interpreted cautiously due to the two-year fall recall period.</div></div><div><h3>Conclusions</h3><div>In middle-aged and older Chinese adults, MSP increases fall risk, particularly with ongoing pain. Frailty might partly explain this risk, indicating the importance of combining pain management with anti-frailty measures for fall prevention.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113005"},"PeriodicalIF":4.3,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype, serum metabolome, and nonalcoholic fatty liver disease in middle-aged and older adults: Association and potential mediation analyses","authors":"Ming-Jun Hu ,&nbsp;Xiao-Min Dong ,&nbsp;Xue-Li Wang,&nbsp;Bei Yao,&nbsp;Fu Yu,&nbsp;Dan Su,&nbsp;Lu Li,&nbsp;Yong-Liang Zhang,&nbsp;Xin-Min Chu","doi":"10.1016/j.exger.2025.112998","DOIUrl":"10.1016/j.exger.2025.112998","url":null,"abstract":"<div><h3>Objective</h3><div>Chronotype represents individual's circadian preference in behavioral and circadian rhythm. This study aimed to investigate association between chronotype and nonalcoholic fatty liver disease (NAFLD) and underlying metabolic mechanisms in middle-aged and older adults.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 744 general middle-aged and older adults. Chronotype was assessed using the Morningness-Eveningness Questionnaire. Untargeted metabolomic profiling was identified using liquid chromatography with high-resolution mass spectrometry. Logistic regression model was used to evaluate association between chronotype and NAFLD. A metabolome-wide association study coupled with mediation analysis was conducted to assess metabolic dysregulation related with chronotype and NAFLD.</div></div><div><h3>Results</h3><div>Chronotype was categorized as morning in 33.1 % of participants, intermediate in 46.8 %, and evening in 20.1 %. After adjustment for covariates, evening chronotype was significantly associated with higher NAFLD risk (OR = 1.70, 95 % CI: 1.03, 2.81) compared to morning chronotype. We identified 81 metabolite features that were significantly associated with chronotype. The comparison between NAFLD and non-NAFLD revealed 251 metabolic differences, implicating 5 metabolic pathways: Arginine biosynthesis, Histidine metabolism, Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, and beta-Alanine metabolism. Mediation analyses suggested that 7 metabolites (such as Asparaginyl-Proline and DG(11D3/11D5/0:0)) might be potential mediators in association of chronotype with NAFLD, with mediated proportions ranging from 12.1 % to 20.6 %.</div></div><div><h3>Conclusion</h3><div>Evening chronotype was associated with increased risk of NAFLD in middle-aged and older adults. Chronotype-related metabolomic alterations, including Asparaginyl-Proline and some lipid metabolites, might represent an associative pathway between chronotype and NAFLD. This highlighted the importance of maintaining circadian rhythms for metabolic health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112998"},"PeriodicalIF":4.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cell–associated DNA methylation responses to exercise in women: A bioinformatics analysis comparing pre- and postmenopausal stages","authors":"Guilherme da Silva Rodrigues ,&nbsp;Natalia Yumi Noronha ,&nbsp;Andressa Crystine da Silva Sobrinho ,&nbsp;Bernadette Jones-Freeman ,&nbsp;Robin Grolaux ,&nbsp;Camila Fernanda Cunha Brandao ,&nbsp;Julio Sergio Marchini ,&nbsp;Lígia Moriguchi Watanabe ,&nbsp;Carla Barbosa Nonino ,&nbsp;Andrew Teschendorff ,&nbsp;Nir Eynon ,&nbsp;Carlos Roberto Bueno Júnior ,&nbsp;Macsue Jacques","doi":"10.1016/j.exger.2025.112996","DOIUrl":"10.1016/j.exger.2025.112996","url":null,"abstract":"<div><h3>Introduction</h3><div>Menopause is associated with immunosenescence and altered immune profiles, potentially reducing immune competence. Physical exercise may counteract these changes by modulating DNA methylation in fitness-related genes.</div></div><div><h3>Methods</h3><div>This observational bioinformatics study analyzed genome-wide DNA methylation profiles derived from whole blood using two publicly available datasets from Brazilian cohorts (Illumina MethylationEPIC 850K). The analysis included pre- (PreM, <em>n</em> = 13; 34 ± 4.7 years) and postmenopausal (PostM, <em>n</em> = 49; 59.8 ± 4.7 years) women who completed supervised combined exercise training. Four linear models were applied to examine associations between DNA methylation, cardiorespiratory fitness (VO₂ peak), and exercise intervention (pre- vs. post-training), while adjusting for age, fat percentage, and estimated immune-cell proportions (EpiDISH). Interaction terms were tested to assess whether immune cell composition or menopausal status modulated the relationship between VO₂ peak, exercise response, and DNA methylation.</div></div><div><h3>Results</h3><div>After adjusting for baseline values using analysis of covariance (ANCOVA), no statistically significant between-group differences were observed in the estimated immune cell proportions (FDR &gt; 0.05). In PostM, exercise-induced DNA methylation changes were significantly associated with baseline VO₂ peak and were modulated by B cells, CD4⁺ T cells, NK cells, and monocytes. Functional enrichment highlighted pathways involved in lipid kinase regulation, nucleobase metabolism, and membrane organization.</div></div><div><h3>Conclusion</h3><div>Postmenopausal women showed distinct epigenetic patterns in response to exercise, although these differences must be interpreted cautiously given the small premenopausal sample size. These results suggest potential immune cell–associated DNA methylation markers to inform personalized exercise strategies supporting healthy aging in women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 112996"},"PeriodicalIF":4.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct patterns of cortical activity associated with cognitive and motor decline in community-dwelling older adults","authors":"Eun-Seon Noh ,&nbsp;Jiwon Yang ,&nbsp;Kai Wang ,&nbsp;Seongryu Bae ,&nbsp;Hyuntae Park","doi":"10.1016/j.exger.2025.113000","DOIUrl":"10.1016/j.exger.2025.113000","url":null,"abstract":"<div><div>This study aimed to examine whether resting-state EEG markers show potential for distinguishing individuals as healthy control, mild cognitive impairment (MCI), and motoric cognitive risk syndrome (MCR), based on their levels of cognitive and motor decline. In this cross-sectional study, we enrolled 87 participants and classified them into three groups. Motor functions were measured by gait speed. Cognitive function was assessed by neuropsychologists using standardized tools, including the Mini-Mental State Examination (MMSE), the Symbol Digit Substitution Test (SDST), and the Paired Associates Learning (PAL) task. Resting-state EEG data were recorded for five minutes with eyes closed, using a 19-channel wireless EEG system. Our results showed that individuals with MCI and MCR exhibited increased frontal theta power and widespread default mode network (DMN) connectivity, reflecting underlying neuropsychological changes. These alterations were most pronounced in the MCR group and were associated with both cognitive and motor decline. Our findings highlight the potential of resting-state EEG as a biomarker for the early detection of cognitive and motor decline in community-dwelling older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113000"},"PeriodicalIF":4.3,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between food inflammation scores of individuals and sarcopenia in U.S. adults: A cross-sectional study from NHANES 2011–2018","authors":"Li Tao ,&nbsp;Qinghuan Yang ,&nbsp;Xinrong Zeng ,&nbsp;Hao Yu ,&nbsp;Jun Mu ,&nbsp;Zhiwen Yan ,&nbsp;Yinghong Tang","doi":"10.1016/j.exger.2025.113004","DOIUrl":"10.1016/j.exger.2025.113004","url":null,"abstract":"<div><div>This cross-sectional study investigates the association between the Food Inflammation Scores of Individuals (FISI34, FISI26-USDA, FISI26-CHINA), derived from the Food Inflammation Index (FII), and sarcopenia in 5489 U.S. adults from the National Health and Nutrition Examination Survey (NHANES 2011–2018). Sarcopenia was defined using appendicular lean mass adjusted for body mass index (BMI). Logistic regression and restricted cubic spline analyses revealed significant positive associations between higher FISI and sarcopenia prevalence, with odds ratios ranging from 1.13 to 1.39 in fully adjusted models. Stronger associations were observed in females, adults aged ≥40 years, Mexican Americans, and those with higher BMI or chronic conditions like hypertension and cardiovascular disease, though no significant interaction effects were observed (p-interaction &gt;0.05). FISI, incorporating individual dietary intake and nutrient reference values, offers a personalized approach compared to the Dietary Inflammatory Index (DII), supporting the evaluation of targeted dietary strategies to address sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113004"},"PeriodicalIF":4.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}