Experimental gerontology最新文献_第4页

Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice 枸杞糖肽通过激活d -半乳糖诱导小鼠的PINK1/帕金森介导的线粒体自噬途径，改善衰老表型并增强心脏代谢。

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2025.112686

Tianchan Peng , Jian Xiang , Yun Tian , Xiaogen Tang , Lina Wang , Lijuan Gao , Oscar Junhong Luo , Li’an Huang , Guobing Chen

Background

Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking.

Objective

To investigate the geroprotective effects of Lycium barbarum glycopeptide (LbGp) and its potential mechanisms in a D-galactose-induced accelerated aging mouse model.

Methods

Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks to induce aging, while LbGp was orally administered (100 mg/kg/day) throughout the study. The geroprotective effects of LbGp were assessed by behavioral tests, cardiac echocardiography, pathohistological and transcriptomic analyses. Transmission electron microscopy was used to observe the ultrastructure of mitochondria. Mitochondrial stress assays and JC-1 fluorescent probe were conducted to evaluate mitochondrial function. Flow cytometer and western blot were performed to assess mitophagy flux.

Results

LbGp treatment improved the aging phenotypes of D-galactose-induced mice, with a pronounced enhancement in cardiac function compared to neurocognitive and skeletal muscle functions. Transcriptome analysis indicated that LbGp ameliorated energy metabolism in the heart. Mitochondrial assays revealed LbGp improved mitochondrial function and preserved structural integrity of the mitochondrial inner membrane. LbGp attenuated mitochondrial fission and restored impaired PINK1/Parkin-mediated mitophagy pathway caused by D-galactose in cardiomyocytes.

Conclusion

LbGp can ameliorate aging phenotypes and enhance cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice. These findings underscore its potential as a therapeutic agent for aging and aging-related cardiovascular diseases.

背景：衰老是一个复杂的生物过程，它会破坏组织结构，损害生理功能，从而导致心血管疾病等与年龄相关的疾病的发生。然而，缺乏有效的治疗策略。目的：探讨枸杞糖肽（LbGp）在d -半乳糖诱导的加速衰老小鼠模型中的保护作用及其可能机制。方法：小鼠皮下注射d -半乳糖（500 mg/kg/d） 12周诱导衰老，同时在整个研究过程中口服LbGp （100 mg/kg/d）。通过行为试验、心脏超声心动图、病理组织学和转录组学分析评估LbGp的老年保护作用。透射电镜观察线粒体超微结构。采用线粒体应激试验和JC-1荧光探针评价线粒体功能。流式细胞仪和western blot检测细胞自噬通量。结果：LbGp治疗改善了d -半乳糖诱导小鼠的衰老表型，与神经认知和骨骼肌功能相比，心脏功能明显增强。转录组分析表明LbGp改善了心脏的能量代谢。线粒体分析显示，LbGp改善了线粒体功能，并保持了线粒体内膜的结构完整性。LbGp可减弱线粒体分裂，恢复d -半乳糖引起的心肌细胞PINK1/ parkinson介导的线粒体自噬通路受损。结论：LbGp可通过激活d -半乳糖诱导小鼠的PINK1/ parkinson介导的线粒体自噬通路，改善衰老表型，增强心脏代谢。这些发现强调了它作为一种治疗衰老和与衰老相关的心血管疾病的药物的潜力。

{"title":"Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice","authors":"Tianchan Peng , Jian Xiang , Yun Tian , Xiaogen Tang , Lina Wang , Lijuan Gao , Oscar Junhong Luo , Li’an Huang , Guobing Chen","doi":"10.1016/j.exger.2025.112686","DOIUrl":"10.1016/j.exger.2025.112686","url":null,"abstract":"<div><h3>Background</h3><div>Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking.</div></div><div><h3>Objective</h3><div>To investigate the geroprotective effects of <em>Lycium barbarum</em> glycopeptide (LbGp) and its potential mechanisms in a D-galactose-induced accelerated aging mouse model.</div></div><div><h3>Methods</h3><div>Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks to induce aging, while LbGp was orally administered (100 mg/kg/day) throughout the study. The geroprotective effects of LbGp were assessed by behavioral tests, cardiac echocardiography, pathohistological and transcriptomic analyses. Transmission electron microscopy was used to observe the ultrastructure of mitochondria. Mitochondrial stress assays and JC-1 fluorescent probe were conducted to evaluate mitochondrial function. Flow cytometer and western blot were performed to assess mitophagy flux.</div></div><div><h3>Results</h3><div>LbGp treatment improved the aging phenotypes of D-galactose-induced mice, with a pronounced enhancement in cardiac function compared to neurocognitive and skeletal muscle functions. Transcriptome analysis indicated that LbGp ameliorated energy metabolism in the heart. Mitochondrial assays revealed LbGp improved mitochondrial function and preserved structural integrity of the mitochondrial inner membrane. LbGp attenuated mitochondrial fission and restored impaired PINK1/Parkin-mediated mitophagy pathway caused by D-galactose in cardiomyocytes.</div></div><div><h3>Conclusion</h3><div>LbGp can ameliorate aging phenotypes and enhance cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice. These findings underscore its potential as a therapeutic agent for aging and aging-related cardiovascular diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112686"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis 支链氨基酸水平与勃起功能障碍风险相关：孟德尔随机分析。

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2025.112677

Yijian Deng , Liying Zeng , Yigui Lai , Shuai Ji , Baizhao Peng , Hanqi Lu , Ming Wang , Hiu Yee Kwan , Qi Wang , Xiaoshan Zhao

Background

Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain.

Methods

The bidirectional Mendelian randomization (MR) study used the genetic data from genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with total BCAAs, leucine, isoleucine, and valine. The genetic data for ED were acquired from the FinnGen study (n = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. Cochrane's Q test was utilized to evaluate heterogeneity within the results, while the MR-Egger intercept test was utilized to evaluate the Level pleiotropy. A sensitivity analysis was performed employing leave-one-out analysis.

Results

The MR analysis results indicate a positive correlation between levels of total BCAA (OR = 1.984, 95 % CI = 1.018–3.868, P = 0.044), leucine (OR = 2.277, 95 % CI = 1.121–4.626, P = 0.023), isoleucine (OR = 2.584, 95 % CI = 1.167–5.722, P = 0.019), valine (OR = 1.894, 95 % CI = 1.119–3.206, P = 0.017), and the risk of ED. Sensitivity tests confirmed the accuracy and robustness of the study findings. Moreover, the reverse MR analysis found no association between ED and the BCAAs.

Conclusion

The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.

背景：勃起功能障碍（ED）是一种常见的男性性功能障碍，显著影响患者的生活质量，也被认为是心血管疾病（CVD）事件的前兆。支链氨基酸（BCAAs）来源于膳食摄入，主要参与能量代谢。先前的研究强调了BCAAs与CVD之间的关联，但BCAAs与ED之间的因果关系仍不确定。方法：双向孟德尔随机化（MR）研究使用全基因组关联研究（GWAS）的遗传数据来鉴定与总支链氨基酸、亮氨酸、异亮氨酸和缬氨酸相关的单核苷酸多态性（snp）。ED的遗传数据来自FinnGen研究（n = 95,178）。用于评估因果关系的主要方法是反方差加权（IVW）法，辅以MR-Egger、加权中位数和简单中位数分析。采用Cochrane’s Q检验评价结果的异质性，采用MR-Egger截距检验评价水平多效性。采用留一分析进行敏感性分析。结果:分析结果显示先生总BCAA的水平之间的正相关关系(或 = 1.984,95 % CI = 1.018 - -3.868,P = 0.044),亮氨酸(或 = 2.277,95 % CI = 1.121 - -4.626,P = 0.023),异亮氨酸(或 = 2.584,95 % CI = 1.167 - -5.722,P = 0.019),缬氨酸(或 = 1.894,95 % CI = 1.119 - -3.206,P = 0.017),和ED的危险。敏感性测试证实了研究结果的准确性和鲁棒性。此外，反向MR分析发现ED与BCAAs之间没有关联。结论：本分析结果表明循环BCAA浓度与ED风险呈正相关，但其潜在机制有待进一步研究。

{"title":"Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis","authors":"Yijian Deng , Liying Zeng , Yigui Lai , Shuai Ji , Baizhao Peng , Hanqi Lu , Ming Wang , Hiu Yee Kwan , Qi Wang , Xiaoshan Zhao","doi":"10.1016/j.exger.2025.112677","DOIUrl":"10.1016/j.exger.2025.112677","url":null,"abstract":"<div><h3>Background</h3><div>Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain.</div></div><div><h3>Methods</h3><div>The bidirectional Mendelian randomization (MR) study used the genetic data from genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with total BCAAs, leucine, isoleucine, and valine. The genetic data for ED were acquired from the FinnGen study (<em>n</em> = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. Cochrane's Q test was utilized to evaluate heterogeneity within the results, while the MR-Egger intercept test was utilized to evaluate the Level pleiotropy. A sensitivity analysis was performed employing leave-one-out analysis.</div></div><div><h3>Results</h3><div>The MR analysis results indicate a positive correlation between levels of total BCAA (OR = 1.984, 95 % CI = 1.018–3.868, <em>P</em> = 0.044), leucine (OR = 2.277, 95 % CI = 1.121–4.626, <em>P</em> = 0.023), isoleucine (OR = 2.584, 95 % CI = 1.167–5.722, <em>P</em> = 0.019), valine (OR = 1.894, 95 % CI = 1.119–3.206, <em>P</em> = 0.017), and the risk of ED. Sensitivity tests confirmed the accuracy and robustness of the study findings. Moreover, the reverse MR analysis found no association between ED and the BCAAs.</div></div><div><h3>Conclusion</h3><div>The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112677"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study 健康生活方式评分轨迹对中老年人群全因死亡率的影响：来自17年回顾性队列研究的发现

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2025.112681

Jeong Min Yang , Jieun Hwang

Purpose

Recently, the World Health Organization has emphasized the importance of a healthy lifestyle in reducing severe illnesses and premature mortality. To evaluate this, the Healthy Lifestyle Score (HLS), which focuses on health protecting behaviors (e.g., smoking, alcohol consumption, physical activity, body mass index), is widely used. However, as HLS may fluctuate over time, there is increasing focus on monitoring HLS trends. Accordingly, this study aims to track HLS trajectories (HLST) and examine their association with mortality among middle-aged and older Koreans.

Methods

After excluding missing values, data from 6249 participants were analyzed using the group-based trajectory model (GBTM) to classify HLST, based on the first to fourth waves of the Korean Longitudinal Study of Aging (KLoSA). The chi-square test and Cox proportional hazards model were employed to examine the association between HLST and all-cause mortality over a 10-year follow-up period (December 31, 2012, to December 31, 2022; 3650 days).

Results

Three HLST groups were identified in the GBTM analysis. These were the Poor HLST (17.8 %), Average HLST (42.9 %), and Good HLST (39.4 %) groups. Compared to the good HLST, the poor HLST had higher mortality at 1 year (hazard ratio [HR]: 1.98, p: 0.029), 3 years (HR: 1.78, p: 0.001), 5 years (HR: 1.52, p: 0.002), 7 years (HR: 1.39, p: 0.002), and 10 years (HR: 1.40, p: 0.000). Furthermore, stratified analysis by sex, age, marital status and residential region showed that male, ≥65 years, single and urban area groups had a strong association between HLST and all-cause mortality.

Conclusion

The findings of this study underscore the necessity of policies and institutional measures grounded in community networks to mitigate the risk of all-cause mortality among vulnerable groups with persistently poor HLST.

目的：最近，世界卫生组织强调了健康的生活方式对减少严重疾病和过早死亡的重要性。为了评估这一点，健康生活方式评分（HLS）被广泛使用，它侧重于保护健康的行为（例如，吸烟、饮酒、体育活动、体重指数）。然而，由于HLS可能随时间波动，因此越来越关注监测HLS趋势。因此，本研究旨在追踪HLS轨迹（HLST）并检查其与中老年韩国人死亡率的关系。方法：在排除缺失值后，基于韩国老龄化纵向研究（KLoSA）的第一至第四波，使用基于群体的轨迹模型（GBTM）对6249名参与者的数据进行分类。采用卡方检验和Cox比例风险模型，在10年随访期间(2012年12月31日至2022年12月31日； 3650天)。结果：在GBTM分析中鉴定出3个HLST组。分为不良HLST组（17.8 %）、平均HLST组（42.9 %）和良好HLST组（39.4 %）。与良好的HLST相比，较差的HLST在1 年（风险比[HR]: 1.98, p: 0.029）、3 年（风险比[HR]: 1.78, p: 0.001）、5 年（风险比[HR]: 1.52, p: 0.002）、7 年（风险比：1.39,p: 0.002）和10 年（风险比：1.40,p: 0.000）的死亡率更高。此外，按性别、年龄、婚姻状况和居住区域进行的分层分析表明，男性、≥65 岁、单身和城市地区组HLST与全因死亡率之间存在很强的关联。结论：本研究的结果强调了以社区网络为基础的政策和制度措施的必要性，以减轻HLST持续较差的弱势群体的全因死亡率风险。

{"title":"Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study","authors":"Jeong Min Yang , Jieun Hwang","doi":"10.1016/j.exger.2025.112681","DOIUrl":"10.1016/j.exger.2025.112681","url":null,"abstract":"<div><h3>Purpose</h3><div>Recently, the World Health Organization has emphasized the importance of a healthy lifestyle in reducing severe illnesses and premature mortality. To evaluate this, the Healthy Lifestyle Score (HLS), which focuses on health protecting behaviors (e.g., smoking, alcohol consumption, physical activity, body mass index), is widely used. However, as HLS may fluctuate over time, there is increasing focus on monitoring HLS trends. Accordingly, this study aims to track HLS trajectories (HLST) and examine their association with mortality among middle-aged and older Koreans.</div></div><div><h3>Methods</h3><div>After excluding missing values, data from 6249 participants were analyzed using the group-based trajectory model (GBTM) to classify HLST, based on the first to fourth waves of the Korean Longitudinal Study of Aging (KLoSA). The chi-square test and Cox proportional hazards model were employed to examine the association between HLST and all-cause mortality over a 10-year follow-up period (December 31, 2012, to December 31, 2022; 3650 days).</div></div><div><h3>Results</h3><div>Three HLST groups were identified in the GBTM analysis. These were the Poor HLST (17.8 %), Average HLST (42.9 %), and Good HLST (39.4 %) groups. Compared to the good HLST, the poor HLST had higher mortality at 1 year (hazard ratio [HR]: 1.98, p: 0.029), 3 years (HR: 1.78, p: 0.001), 5 years (HR: 1.52, p: 0.002), 7 years (HR: 1.39, p: 0.002), and 10 years (HR: 1.40, p: 0.000). Furthermore, stratified analysis by sex, age, marital status and residential region showed that male, ≥65 years, single and urban area groups had a strong association between HLST and all-cause mortality.</div></div><div><h3>Conclusion</h3><div>The findings of this study underscore the necessity of policies and institutional measures grounded in community networks to mitigate the risk of all-cause mortality among vulnerable groups with persistently poor HLST.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112681"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of physical exercise through multivariate analysis in sedentary adults and elderly: An analysis of physical fitness, health and anthropometrics 通过对久坐不动的成年人和老年人进行多变量分析得出体育锻炼的益处：一项对身体健康、健康和人体测量学的分析。

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2024.112669

Guilherme da Silva Rodrigues , Andressa Crystine da Silva Sobrinho , Gabriel Peinado Costa , Leonardo Santos Lopes da Silva , João Gabriel Ribeiro de Lima , Leonardo da Silva Gonçalves , Larissa Chacon Finzeto , Carlos Roberto Bueno Júnior

This study employed multivariate analysis to investigate the effects of a 14-week multicomponent training program on sedentary adults and older populations, focusing on improvements in physical fitness, health markers, and anthropometric measures. The data included 376 participants aged 30 to 84 years who had been inactive for at least 3 months. Results showed that participants aged 71 and above had lower systolic blood pressure, height, body mass, elbow flexion and extension, sitting and standing up from a chair, agility, 6-Minute Walk Test (6MWT), and handgrip strength values compared to younger age groups (p < 0.05). Initially, the 6MWT was inversely correlated with anthropometric measures and positively correlated with strength tests, but after the intervention, it remained correlated only with handgrip strength and agility. Interestingly, the elbow flexion and extension strongly correlated with other fitness measures pre-intervention, but these relationships weakened afterward. Agility became a key intermediary variable in the analysis. Despite improvements, anthropometric variables like body mass and waist circumference continued to have a strong relationship with fitness outcomes. Significant gains were observed in the 6MWT and elbow flexion and extension (p < 0.05), indicating improvements in aerobic fitness and strength. Multivariate analysis showed that hip circumference, chair stand test, handgrip strength, and agility significantly influenced 6MWT performance. Using multivariate analysis, we were able to highlight the importance of incorporating regular exercise into daily life to promote active and healthy aging. Furthermore, agility emerged as the most significant intermediate variable after the intervention. This insight suggests that improvements in agility may be crucial for physical fitness and overall health.

本研究采用多变量分析来调查14周多成分训练计划对久坐不动的成年人和老年人的影响，重点关注身体健康、健康指标和人体测量指标的改善。数据包括376名年龄在30岁至84岁 之间的参与者，他们至少有3个 个月不运动。结果显示，与年轻年龄组相比，71岁及以上的参与者收缩压、身高、体重、肘部屈曲和伸展、从椅子上坐起来和站起来、敏捷性、6分钟步行测试（6MWT）和握力值都较低

{"title":"Benefits of physical exercise through multivariate analysis in sedentary adults and elderly: An analysis of physical fitness, health and anthropometrics","authors":"Guilherme da Silva Rodrigues , Andressa Crystine da Silva Sobrinho , Gabriel Peinado Costa , Leonardo Santos Lopes da Silva , João Gabriel Ribeiro de Lima , Leonardo da Silva Gonçalves , Larissa Chacon Finzeto , Carlos Roberto Bueno Júnior","doi":"10.1016/j.exger.2024.112669","DOIUrl":"10.1016/j.exger.2024.112669","url":null,"abstract":"<div><div>This study employed multivariate analysis to investigate the effects of a 14-week multicomponent training program on sedentary adults and older populations, focusing on improvements in physical fitness, health markers, and anthropometric measures. The data included 376 participants aged 30 to 84 years who had been inactive for at least 3 months. Results showed that participants aged 71 and above had lower systolic blood pressure, height, body mass, elbow flexion and extension, sitting and standing up from a chair, agility, 6-Minute Walk Test (6MWT), and handgrip strength values compared to younger age groups (p < 0.05). Initially, the 6MWT was inversely correlated with anthropometric measures and positively correlated with strength tests, but after the intervention, it remained correlated only with handgrip strength and agility. Interestingly, the elbow flexion and extension strongly correlated with other fitness measures pre-intervention, but these relationships weakened afterward. Agility became a key intermediary variable in the analysis. Despite improvements, anthropometric variables like body mass and waist circumference continued to have a strong relationship with fitness outcomes. Significant gains were observed in the 6MWT and elbow flexion and extension (p < 0.05), indicating improvements in aerobic fitness and strength. Multivariate analysis showed that hip circumference, chair stand test, handgrip strength, and agility significantly influenced 6MWT performance. Using multivariate analysis, we were able to highlight the importance of incorporating regular exercise into daily life to promote active and healthy aging. Furthermore, agility emerged as the most significant intermediate variable after the intervention. This insight suggests that improvements in agility may be crucial for physical fitness and overall health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112669"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foresight older adults' quality of life in the aging crisis in Iran: A systematic review and meta-analysis 伊朗老龄化危机中预见老年人的生活质量：一项系统回顾和荟萃分析。

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2024.112671

Raheleh Alimoradzadeh , Katayoun Jahangiri , Roya Alimoradzadeh

Introduction

To provide foresight for the older adults' quality of life (QOL) in the aging crisis in Iran, this systematic review and meta-analysis study is conducted.

Methods

All relevant articles were searched in the English and Persian databases such as Scopus, Web of Science, PubMed, Google Scholar, SID, and Medex regardless of the time range up to December 2023.

Results

Out of 348 articles found, 8 articles were included finally. In total, the QOL of 1093 older adults' people with a mean age of 71.55 ± 6.91 years were evaluated. The study showed that the overall average of the QOL of the older adults is 58.5 ± 10.1 The overall average QOL of the older adults at the Iranian community level was 57.6 ± 15.5. The overall average QOL of the older adults in nursing homes are 60.1 ± 29.7.

Conclusion

The Iranian older adults have an average QOL and paying attention to the older adults and their needs and designing interventions to improve their health status should be on the agenda of health policymakers.

前言：为了对伊朗老龄化危机中老年人的生活质量（QOL）提供前瞻性，本研究进行了系统回顾和荟萃分析研究。方法：在Scopus、Web of Science、PubMed、谷歌Scholar、SID和Medex等英文和波斯语数据库中检索截至2023年12月的所有相关文章。结果：共检索到348篇文献，最终纳入8篇。共对1093名平均年龄为71.55 ± 6.91 岁的老年人进行生活质量评价。研究结果显示，伊朗社区老年人总体平均生活质量为58.5 ± 10.1，伊朗社区老年人总体平均生活质量为57.6 ± 15.5。养老院老年人总体平均生活质量为60.1 ± 29.7。结论：伊朗老年人的生活质量处于中等水平，关注老年人及其需求，设计改善老年人健康状况的干预措施应列入卫生政策制定者的议程。

{"title":"Foresight older adults' quality of life in the aging crisis in Iran: A systematic review and meta-analysis","authors":"Raheleh Alimoradzadeh , Katayoun Jahangiri , Roya Alimoradzadeh","doi":"10.1016/j.exger.2024.112671","DOIUrl":"10.1016/j.exger.2024.112671","url":null,"abstract":"<div><h3>Introduction</h3><div>To provide foresight for the older adults' quality of life (QOL) in the aging crisis in Iran, this systematic review and meta-analysis study is conducted.</div></div><div><h3>Methods</h3><div>All relevant articles were searched in the English and Persian databases such as Scopus, Web of Science, PubMed, Google Scholar, SID, and Medex regardless of the time range up to December 2023.</div></div><div><h3>Results</h3><div>Out of 348 articles found, 8 articles were included finally. In total, the QOL of 1093 older adults' people with a mean age of 71.55 ± 6.91 years were evaluated. The study showed that the overall average of the QOL of the older adults is 58.5 ± 10.1 The overall average QOL of the older adults at the Iranian community level was 57.6 ± 15.5. The overall average QOL of the older adults in nursing homes are 60.1 ± 29.7.</div></div><div><h3>Conclusion</h3><div>The Iranian older adults have an average QOL and paying attention to the older adults and their needs and designing interventions to improve their health status should be on the agenda of health policymakers.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112671"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents 通过双重任务抵抗训练和去训练改善养老院居民血清氧化还原平衡、炎症状态、身体功能和认知能力。

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2024.112662

Erivaldo Machado Araújo , Hélio José Coelho-Júnior , Caio Victor Sousa , Thiago dos Santos Rosa , Ivo Vieira Sousa Neto , Emanuele Marzetti , Octávio Luiz Franco , Samuel da Silva Aguiar

Objective

This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults.

Methods

The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14–15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2–13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation.

Results

Dual-task RT significantly enhanced balance (p = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (p = 0.008) and post-detraining (p = 0.015) relative to baseline. Cognitive ability showed significant improvements (p < 0.05). The CAT/TBARS ratio increased significantly post-training (p < 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (p < 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p < 0.05).

Conclusion

Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining.

目的：探讨双任务阻力训练（RT）和去训练对住院老年人身体机能、认知能力、血脂、肾功能、氧化应激指标和慢性炎症的影响。方法：研究纳入11名老年人（83.09 ± 8.1 岁），居住在长期护理机构，为期42 周，在第1、14-15、28和42周进行评估。第一次评估后的最初12周 （第2-13周）作为预控制，在此期间参与者保持日常活动。从第16周到第27周实施双任务阻力训练方案，然后从第29周到第41周进行去训练期。评估包括临床特征、身体功能、认知能力、血液生化参数、氧化应激和慢性炎症。结果：与对照组相比，双任务RT显著提高了训练后平衡性（p = 0.027）和4 m步行速度（p = 0.027）。相对于控制前，它还减少了训练后（p = 0.008）和去训练后（p = 0.015）坐立测试的完成时间。结论：在12 周的时间里，双任务RT治疗改善了住院老年人的身体功能、认知能力、肌肉力量、氧化应激指标和慢性炎症。此外，即使在一段时间后，这些好处仍然持续。

{"title":"Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents","authors":"Erivaldo Machado Araújo , Hélio José Coelho-Júnior , Caio Victor Sousa , Thiago dos Santos Rosa , Ivo Vieira Sousa Neto , Emanuele Marzetti , Octávio Luiz Franco , Samuel da Silva Aguiar","doi":"10.1016/j.exger.2024.112662","DOIUrl":"10.1016/j.exger.2024.112662","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults.</div></div><div><h3>Methods</h3><div>The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14–15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2–13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation.</div></div><div><h3>Results</h3><div>Dual-task RT significantly enhanced balance (<em>p</em> = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (<em>p</em> = 0.008) and post-detraining (<em>p</em> = 0.015) relative to baseline. Cognitive ability showed significant improvements (<em>p</em> < 0.05). The CAT/TBARS ratio increased significantly post-training (<em>p</em> < 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (<em>p</em> < 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p < 0.05).</div></div><div><h3>Conclusion</h3><div>Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112662"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia: A cross-sectional study 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率（NHHR）与肌肉减少症之间的关系：一项横断面研究。

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2025.112680

Xiudeng Yang , Zheng Zhong

Background

The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a newly developed lipid parameter that's used to evaluate cardiovascular disease risk. However, its association with sarcopenia risk has not been explored before.

Methods

Data on NHHR and sarcopenia were based on the secondary analysis of the years 2011–2018 of National Health and Nutrition Examination Survey (NHANES) dataset. NHHR was nature log-transformed (LnNHHR) to achieve a normal distribution. A multivariate logistic regression and a restricted cubic spline (RCS) model adjusted for associated factors were utilized to evaluate the correlation between NHHR and sarcopenia. Subgroup and sensitivity analyses were conducted to verify the robustness of the findings.

Results

The study cohort comprised 7069 participants, of whom 6497 (91.91 %) were sarcopenia-free, and 572 (8.09 %) exhibited sarcopenia. A significant increase in NHHR was observed in the sarcopenia group compared to the non-sarcopenic group (P < 0.001). Multivariate logistic regression analysis revealed that sarcopenia was independently linked to NHHR [odds ratio (OR): 1.394, P = 0.007]. A linear relationship was identified between NHHR and sarcopenia risk (P_non-linear = 0.108). Interaction analysis indicated that the relationship between NHHR and sarcopenia risk was not significantly modified by gender, sex, poverty income ratio, education, smoking status, or race.

Conclusion

NHHR was significantly associated with an elevated risk of sarcopenia among U.S. adults. Further research is warranted to elucidate the underlying physiological mechanisms through which NHHR influences sarcopenia development.

背景：非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）是近年来发展起来的用于评价心血管疾病风险的血脂参数。然而，它与肌肉减少症风险的关系以前没有被探讨过。方法：基于2011-2018年国家健康与营养检查调查（NHANES）数据集的二次分析，获取NHHR和肌肉减少症数据。NHHR采用自然对数变换（LnNHHR），达到正态分布。采用多变量logistic回归和限制三次样条（RCS）模型对相关因素进行调整，评估NHHR与肌肉减少症之间的相关性。进行亚组分析和敏感性分析以验证研究结果的稳健性。结果：研究队列包括7069名参与者，其中6497名（91.91%）无肌肉减少症，572名（8.09%）出现肌肉减少症。与非肌少症组相比，肌少症组NHHR显著升高（P非线性= 0.108）。交互作用分析表明，NHHR与肌少症风险之间的关系不受性别、性别、贫困收入比、教育程度、吸烟状况或种族的显著影响。结论：NHHR与美国成年人肌肉减少症风险升高显著相关。需要进一步的研究来阐明NHHR影响肌肉减少症发展的潜在生理机制。

{"title":"The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia: A cross-sectional study","authors":"Xiudeng Yang , Zheng Zhong","doi":"10.1016/j.exger.2025.112680","DOIUrl":"10.1016/j.exger.2025.112680","url":null,"abstract":"<div><h3>Background</h3><div>The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a newly developed lipid parameter that's used to evaluate cardiovascular disease risk. However, its association with sarcopenia risk has not been explored before.</div></div><div><h3>Methods</h3><div>Data on NHHR and sarcopenia were based on the secondary analysis of the years 2011–2018 of National Health and Nutrition Examination Survey (NHANES) dataset. NHHR was nature log-transformed (LnNHHR) to achieve a normal distribution. A multivariate logistic regression and a restricted cubic spline (RCS) model adjusted for associated factors were utilized to evaluate the correlation between NHHR and sarcopenia. Subgroup and sensitivity analyses were conducted to verify the robustness of the findings.</div></div><div><h3>Results</h3><div>The study cohort comprised 7069 participants, of whom 6497 (91.91 %) were sarcopenia-free, and 572 (8.09 %) exhibited sarcopenia. A significant increase in NHHR was observed in the sarcopenia group compared to the non-sarcopenic group (<em>P</em> < 0.001). Multivariate logistic regression analysis revealed that sarcopenia was independently linked to NHHR [odds ratio (OR): 1.394, <em>P</em> = 0.007]. A linear relationship was identified between NHHR and sarcopenia risk (<em>P</em><sub>non-linear</sub> = 0.108). Interaction analysis indicated that the relationship between NHHR and sarcopenia risk was not significantly modified by gender, sex, poverty income ratio, education, smoking status, or race.</div></div><div><h3>Conclusion</h3><div>NHHR was significantly associated with an elevated risk of sarcopenia among U.S. adults. Further research is warranted to elucidate the underlying physiological mechanisms through which NHHR influences sarcopenia development.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112680"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome 慢性冠状动脉综合征患者神经退行性疾病的血液生物标志物与死亡率、心脑血管事件的关系

IF 3.9

Experimental gerontology

Pub Date : 2025-02-01 DOI: 10.1016/j.exger.2025.112684

Valerie Lohner , Laura Perna , Ben Schöttker , Robert Perneczky , Hermann Brenner , Ute Mons

Background

In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).

Methods

We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ₄₀, Aβ₄₂, Aβ₄₂/Aβ₄₀) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype.

Results

Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ₄₀/Aβ₄₂-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on ApoE ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes.

Conclusions

In persons with CSS, NfL and the Aβ₄₀/Aβ₄₂-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by ApoE genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases.

背景：鉴于越来越多的证据强调心脏和大脑健康之间的相互作用，我们研究了慢性冠状动脉综合征（CCS）患者神经退行性疾病生物标志物与不良结局（全因和心血管死亡率、主要心血管事件和中风）的关联。方法：我们使用了一组CCS患者的数据，这些患者在20年的随访中记录了主要不良事件。我们使用HD-1分析仪上的单分子阵列技术测量基线血液样本中神经退行性疾病的生物标志物。这些包括神经元（神经丝轻链（NfL）（n = 379））和胶质神经变性（胶质纤维酸性蛋白（GFAP）（n = 379））和阿尔茨海默病病理(磷酸化tau181 （n = 379)，总tau （n = 377）和β淀粉样蛋白（Aβ40, Aβ42, Aβ42/Aβ40）（n = 377））的生物标志物。我们应用cox比例风险模型来评估这些生物标志物与不良结局的关联，调整协变量并探索与载脂蛋白E (ApoE) ε4基因型的相互作用。结果：NfL水平较高的参与者全因死亡率和心血管死亡率增加(每增加一个标准差的风险比（95%置信区间）：全因死亡率：1.36 (1.10-1.68)；心血管死亡率：1.42(1.05-1.93))。a - β40/ a - β42比值与卒中事件相关（0.72(0.52-1.00)）。GFAP与全因死亡率和卒中发生率的相关性取决于ApoE ε4基因型。其他生物标志物与研究结果无显著相关性。结论：在CSS患者中，NfL和a - β40/ a - β42比值分别与死亡率和卒中发生率相关，而GFAP与不良结局的相关性因ApoE基因型而异。这些生物标志物可能与衰老、心血管和神经退行性疾病有关。

{"title":"Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome","authors":"Valerie Lohner , Laura Perna , Ben Schöttker , Robert Perneczky , Hermann Brenner , Ute Mons","doi":"10.1016/j.exger.2025.112684","DOIUrl":"10.1016/j.exger.2025.112684","url":null,"abstract":"<div><h3>Background</h3><div>In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).</div></div><div><h3>Methods</h3><div>We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (<em>n</em> = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (<em>n</em> = 377), and amyloid β (Aβ<sub>40</sub>, Aβ<sub>42</sub>, Aβ<sub>42</sub>/Aβ<sub>40</sub>) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (<em>ApoE</em>) ε4 genotype.</div></div><div><h3>Results</h3><div>Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ<sub>40</sub>/Aβ<sub>42</sub>-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on <em>ApoE</em> ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes.</div></div><div><h3>Conclusions</h3><div>In persons with CSS, NfL and the Aβ<sub>40</sub>/Aβ<sub>42</sub>-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by <em>ApoE</em> genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112684"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia

IF 3.9

Experimental gerontology

Pub Date : 2025-01-30 DOI: 10.1016/j.exger.2025.112692

Beatrice Arosio , Paolo Dionigi Rossi , Evelyn Ferri , Ernesto Consorti , Simona Ciccone , Tiziano Angelo Lucchi , Nicola Montano

Background

During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty. This study analysed the same markers in older people with cognitive decline and/or dementia.

Methods

The cohort consisted of 776 community-dwelling older people: 235 patients with mild cognitive impairment, 63 with Alzheimer's disease (AD), 175 with mixed dementia (MD), and 303 subjects without cognitive decline. Plasma concentrations of inflammatory cytokines and peripheral markers of neuroinflammation were analysed by next-generation ELISA.

Results

After adjustment for age, sex, frailty, education and Apolipoprotein E genotype, only interleukin-10, interleukin-1β, and neurofilament light chain were associated with the risk for AD and MD. Moreover, interleukin-6 showed a weak association only with AD.

Conclusions

Our data showed similar associations between AD and MD, supporting the concept that late-onset dementia is a complex outcome of aging, intimately linked to the individual's health status as well as frailty.

{"title":"The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia","authors":"Beatrice Arosio , Paolo Dionigi Rossi , Evelyn Ferri , Ernesto Consorti , Simona Ciccone , Tiziano Angelo Lucchi , Nicola Montano","doi":"10.1016/j.exger.2025.112692","DOIUrl":"10.1016/j.exger.2025.112692","url":null,"abstract":"<div><h3>Background</h3><div>During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty. This study analysed the same markers in older people with cognitive decline and/or dementia.</div></div><div><h3>Methods</h3><div>The cohort consisted of 776 community-dwelling older people: 235 patients with mild cognitive impairment, 63 with Alzheimer's disease (AD), 175 with mixed dementia (MD), and 303 subjects without cognitive decline. Plasma concentrations of inflammatory cytokines and peripheral markers of neuroinflammation were analysed by next-generation ELISA.</div></div><div><h3>Results</h3><div>After adjustment for age, sex, frailty, education and Apolipoprotein E genotype, only interleukin-10, interleukin-1β, and neurofilament light chain were associated with the risk for AD and MD. Moreover, interleukin-6 showed a weak association only with AD.</div></div><div><h3>Conclusions</h3><div>Our data showed similar associations between AD and MD, supporting the concept that late-onset dementia is a complex outcome of aging, intimately linked to the individual's health status as well as frailty.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112692"},"PeriodicalIF":3.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous extract of Atractylodes macrocephala Koidz. improves dexamethasone-induced skeletal muscle atrophy in mice by enhancing mitochondrial biological function

IF 3.9

Experimental gerontology

Pub Date : 2025-01-29 DOI: 10.1016/j.exger.2025.112693

Mingzhu Ye, Peng Lai, Yajing Fang, Yafeng Li, Fang Wang, Junqi Yu, Yuyu Zhang, Qiaoyi Yang, Jinsen Zhu, Xiaoqin Xie, Ningrong Yang, Tong Peng

Purpose

The study aims to investigate the therapeutic effects of the aqueous extract of Atractylodes macrocephala Koidz. (AEA) on dexamethasone (Dex) -induced sarcopenia in mice and to explore its possible mechanisms of action.

Methods

This study utilized bioinformatics analysis to explore the primary pathogenic mechanisms of age-related sarcopenia and Dex-induced muscle atrophy. In animal experiments, a mouse model of muscle atrophy was established using Dex, and different doses of AEA were administered for treatment. The therapeutic effects of AEA were evaluated through tests of motor ability and histological analysis, and the molecular mechanisms predicted by bioinformatics were verified by measuring the expression levels of related genes.

Results

Bioinformatics analysis suggests that there may be shared pathogenic mechanisms related to mitochondrial function and structure between age-related sarcopenia and Dex-induced muscle atrophy. Dex significantly reduced the mass, function, and cross-sectional area of muscle fibers in mice, and also induced changes in muscle fiber types. In contrast, AEA significantly ameliorated the aforementioned atrophic effects caused by Dex. The modulation of mitochondrial biogenesis and dynamics may be a crucial mechanism by which AEA exerts its anti-sarcopenia effects.

Conclusion

AEA can significantly alleviate the symptoms of Dex-induced skeletal muscle atrophy in mice by improving mitochondrial function, indicating its potential for clinical application in the prevention and treatment of age-related sarcopenia.

{"title":"Aqueous extract of Atractylodes macrocephala Koidz. improves dexamethasone-induced skeletal muscle atrophy in mice by enhancing mitochondrial biological function","authors":"Mingzhu Ye, Peng Lai, Yajing Fang, Yafeng Li, Fang Wang, Junqi Yu, Yuyu Zhang, Qiaoyi Yang, Jinsen Zhu, Xiaoqin Xie, Ningrong Yang, Tong Peng","doi":"10.1016/j.exger.2025.112693","DOIUrl":"10.1016/j.exger.2025.112693","url":null,"abstract":"<div><h3>Purpose</h3><div>The study aims to investigate the therapeutic effects of the aqueous extract of <em>Atractylodes macrocephala</em> Koidz. (AEA) on dexamethasone (Dex) -induced sarcopenia in mice and to explore its possible mechanisms of action.</div></div><div><h3>Methods</h3><div>This study utilized bioinformatics analysis to explore the primary pathogenic mechanisms of age-related sarcopenia and Dex-induced muscle atrophy. In animal experiments, a mouse model of muscle atrophy was established using Dex, and different doses of AEA were administered for treatment. The therapeutic effects of AEA were evaluated through tests of motor ability and histological analysis, and the molecular mechanisms predicted by bioinformatics were verified by measuring the expression levels of related genes.</div></div><div><h3>Results</h3><div>Bioinformatics analysis suggests that there may be shared pathogenic mechanisms related to mitochondrial function and structure between age-related sarcopenia and Dex-induced muscle atrophy. Dex significantly reduced the mass, function, and cross-sectional area of muscle fibers in mice, and also induced changes in muscle fiber types. In contrast, AEA significantly ameliorated the aforementioned atrophic effects caused by Dex. The modulation of mitochondrial biogenesis and dynamics may be a crucial mechanism by which AEA exerts its anti-sarcopenia effects.</div></div><div><h3>Conclusion</h3><div>AEA can significantly alleviate the symptoms of Dex-induced skeletal muscle atrophy in mice by improving mitochondrial function, indicating its potential for clinical application in the prevention and treatment of age-related sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112693"},"PeriodicalIF":3.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0