Experimental gerontology最新文献

{"title":"Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults","authors":"Yan Zhao ,&nbsp;Tingting Chen ,&nbsp;Conghua Ji ,&nbsp;Yuxin Shang ,&nbsp;Yuqing Pan ,&nbsp;Wei Mao","doi":"10.1016/j.exger.2025.113010","DOIUrl":"10.1016/j.exger.2025.113010","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether the NPAR mediates the relationship between stroke and HF.</div></div><div><h3>Methods</h3><div>We analyzed data from 42,101 adults in the NHANES. Multivariable regression models adjusted for confounders were used to assess associations of stroke with NPAR and HF. Restricted cubic spline (RCS) curves were employed to investigate potential non-linear or linear relationships between NPAR and HF. Furthermore, mediation analysis was performed to assess the potential mediating role of NPAR.</div></div><div><h3>Results</h3><div>NPAR levels of participants with HF and/or stroke were higher than those without HF and stroke (<em>P</em> &lt; 0.0001). Following full adjustment, stroke was positively associated with NPAR (β = 0.421, 95 % CI = 0.242, 0.600, <em>P</em> &lt; 0.0001), with stronger associations noted in females (interaction β = 0.450, interaction <em>p</em>-value &lt; 0.001). Similarly, stroke was positively associated with HF (OR = 3.0301, 95 % CI = 2.4143, 3.8030, <em>P</em> &lt; 0.0001). RCS analysis further revealed a nonlinear correlation between NPAR and HF. Furthermore, mediation analysis revealed that NPAR significantly mediated the relationship between stroke and HF (proportion mediated = 3.58 %, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>This study identified that stroke and NPAR are significantly related to HF, which increases the risk of HF in the adults, and the mediating role of NPAR is significant in the relationship between stroke and HF. This finding highlights the necessity of regulating the inflammatory-nutritional.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113010"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomous fall risk assessment in Australian Residential Aged Care Facilities using passive sensors: A feasibility study","authors":"David Silvera-Tawil ,&nbsp;Jane Li ,&nbsp;Liesel Higgins ,&nbsp;Deepa Prabhu ,&nbsp;Jennifer Hewitt ,&nbsp;Katie Packer ,&nbsp;Wei Lu ,&nbsp;Maggie Haertsch ,&nbsp;Marlien Varnfield","doi":"10.1016/j.exger.2025.113013","DOIUrl":"10.1016/j.exger.2025.113013","url":null,"abstract":"<div><h3>Background</h3><div>Falls in residential aged care home (RAC) remain a critical issue in Australia, contributing to diminished quality of life and increased morbidity among older adults. This study investigates the feasibility of passive sensor technologies to proactively identify behavioural changes, such as reduced mobility and sleep disturbances, that may signal elevated fall risk. It also explores resident and staff acceptance of the technology.</div></div><div><h3>Methods</h3><div>An open-label, non-randomized feasibility trial using a single-group, post-test mixed methods design was conducted with 24 residents at a RAC in Sydney, Australia. Ambient and wearable sensor data and clinical records were collected, alongside interviews with residents and staff. Data were analysed using quantitative and qualitative techniques to assess feasibility and user experience.</div></div><div><h3>Results</h3><div>Sensor data revealed diverse resident routines and rapid staff responses to alerts. Predictive analytics showed promise for identifying elevated fall risk, though further validation is needed. Qualitative feedback from 10 residents indicated residents found the system mostly unobtrusive but raised concerns around privacy and false alerts that triggered staff interventions. Despite this, many residents acknowledged its value, especially for individuals with higher vulnerability. Interviews with eight staff members echoed the system's potential to enhance monitoring and safety, but noted technical and training challenges.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that sensor-based monitoring in RACs is technically feasible and generally acceptable. The findings support its integration into aged care as a proactive, person-centred approach to falls management, provided that implementation is supported by thoughtful design, clear communication, and staff training.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113013"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qiliqiangxin capsule improves the cognitive disorders in heart failure rats through regulating blood brain barrier function","authors":"Hongbing Zhao ,&nbsp;Yue Zhao ,&nbsp;Jinfang Dou ,&nbsp;Murong Hei ,&nbsp;Yuqian Gao ,&nbsp;Jiaran Peng ,&nbsp;Zhimiao Wang ,&nbsp;Shuai Zhang ,&nbsp;Haiyan Zhu","doi":"10.1016/j.exger.2025.113007","DOIUrl":"10.1016/j.exger.2025.113007","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the protective effects of Qiliqiangxin capsule (QLQX) against cognitive impairment in rats with heart failure (HF), as well as the underlying mechanisms.</div></div><div><h3>Materials and methods</h3><div>Heart failure was induced in rats by LAD ligation. The animals were randomized into four groups (sham, model, QLQX [0.6 g/kg/d], and valsartan [13.3 mg/kg/d]) and received treatment for 60 days. Cardiac function was evaluated by echocardiography, while cognitive function was assessed using the Morris water maze. Myocardial and hippocampal morphology were examined by HE and Nissl staining, respectively. Hippocampal levels of Ang II, Aβ₄₂, and ROS were quantified via ELISA and DHE staining. Finally, Western blot analysis was performed to measure the expression of AT1R, NF-κB, P-gP, RAGE, and the tight junction proteins (Claudin-5, Occludin).</div></div><div><h3>Results</h3><div>Echocardiographic assessments revealed that QLQX significantly improved cardiac function in rats with HF-induced cognitive impairment. The Morris water maze test demonstrated that, compared with the model group, QLQX treatment enhanced the targeting of swimming path and increased the number of platform crossings—consistently indicating alleviation of cognitive dysfunction. Histological analysis using HE staining confirmed that QLQX preserved myocardial structural integrity. Nissl staining further demonstrated that QLQX mitigated neuronal damage in the hippocampus. Additionally, QLQX reduced the levels of Ang II, AT1R, ROS, and Aβ_42. It also downregulated the expression of NF-κB and P-gP while upregulating that of Claudin-5 and Occludin.</div></div><div><h3>Conclusions</h3><div>QLQX improves cardiac function and mitigates cognitive decline in rats with heart failure. These protective effects likely involve the reduction of Ang II, AT1R, and ROS levels, alongside inhibition of the NF-κB pathway. Furthermore, QLQX upregulates the tight junction proteins Claudin-5 and Occludin, which helps preserve blood-brain barrier (BBB) integrity. This cascade of events ultimately reduces cerebral Aβ deposition.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113007"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism","authors":"Yujie Zhang ,&nbsp;Zhe Pan ,&nbsp;Jiewen Shi ,&nbsp;Jingjing Zhang ,&nbsp;Yongli Chai ,&nbsp;Ye Zhao ,&nbsp;Wei Liu ,&nbsp;Wei'’an Yuan","doi":"10.1016/j.exger.2025.113001","DOIUrl":"10.1016/j.exger.2025.113001","url":null,"abstract":"<div><h3>Background</h3><div>The total flavonoids of Epimedii Folium (<em>Epimedium brevicornu Maxim.</em>) are the main active component, and have unique advantages in sarcopenia intervention. Nevertheless, its efficacy and mechanism of action have not been reported in the literature.</div></div><div><h3>Aim of the study</h3><div>This study aimed to evaluate the impact of TFE on sarcopenia and to elucidate the mechanisms involving the FXR-FGF15 signaling pathway and the gut microbiota-bile acid-skeletal muscle axis.</div></div><div><h3>Methods</h3><div>At the cellular level, the effects of TFE on C2C12 myotube morphology, as well as on myogenic growth factors and atrophy-related markers, were evaluated. At the animal level, the effects of TFE on sarcopenia were investigated through assessments of senescence score, grip strength, body composition, running performance, and histological analysis of skeletal muscle tissue. The levels of inflammatory cytokines in serum were assayed using ELISA to assess the inflammation. Pyrosequencing of bacterial 16S rRNA from the V3–V4 of fecal samples characterized the gut microbiota. Targeted bile acid metabolomics in fecal and skeletal muscle samples were measured using UHPLC-Q-Exactive Orbitrap HRMS. qRT-PCR and western blot were used to evaluate markers related to bile acid synthesis, transport, and absorption, as well as the FXR-FGF15 signaling pathway.</div></div><div><h3>Results</h3><div>TFE helps prevent dexamethasone-induced muscle atrophy and degeneration by upregulating the expression of myogenic growth factors (MyoD, Mef2a, and MyoG) and downregulating the expression of muscle atrophy markers (Trim63, Fbxo32). 12 weeks TFE administration has significant therapeutic properties in SAMP8 mice, as demonstrated by lower senescence score and body fat content; greater grip force, lean muscle content and muscle function (running time and distance), and have the effects of delaying the progression of aging and repairing the pathological damage of skeletal muscle in the SAMP8 mice. Its mechanism of action may involve restoring gut microbiota imbalance and bile acid metabolism disruption, thereby positively regulating FXR-FGF15 signaling.</div></div><div><h3>Conclusions</h3><div>In the present study, TFE was shown to improve dexamethasone-induced muscle atrophy and degeneration in C2C12 myotubes, as evidenced by the restored expression of myogenic markers and the downregulation of atrophy-related genes and proteins. Additionally, TFE can attenuate sarcopenia progression in SAMP8 mice. Its effect was related to the regulation of the gut microbiota-bile acids-skeletal muscle axis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113001"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia, obesity, and functional decline: converging mechanisms and emerging diagnostic frontiers","authors":"Andrea P. Rossi ,&nbsp;Lin Kang ,&nbsp;Ming Yang","doi":"10.1016/j.exger.2025.112993","DOIUrl":"10.1016/j.exger.2025.112993","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112993"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The skeletal muscle function deficit: From an operational definition to clinic results from the InCHIANTI longitudinal study","authors":"Angelo Di Iorio ,&nbsp;Raffaello Pellegrino ,&nbsp;Roberto Paganelli ,&nbsp;Matteo Candeloro ,&nbsp;Stefania Bandinelli ,&nbsp;Toshiko Tanaka ,&nbsp;Luigi Ferrucci","doi":"10.1016/j.exger.2025.113018","DOIUrl":"10.1016/j.exger.2025.113018","url":null,"abstract":"<div><div>Age-related muscle dysfunction is a major contributor to disability, frailty, and poor clinical outcomes in older adults. Skeletal Muscle Function Deficit (SMFD) framework integrates multiple domains as: muscle mass, muscle density, strength, and power to capture a broader spectrum of age-related muscle dysfunction. The primary aims of these analyses are to develop and validate a composite SMFD score and evaluate its association with key geriatric outcome.</div><div>This study used data from the InCHIANTI follow-up study, involving an initial cohort of 1035 older participants, with a total of 3196 assessments. The SMFD score was computed by assigning quintile-based values of muscle area, density, strength, and lower limb power. Associations with adverse health outcomes, and major chronic diseases were analyzed using mixed-effects models.</div><div>The SMFD score declined over time from baseline to the third follow-up was: β ± SE:-0.64 ± 0.12 (<em>p</em>-value &lt; 0.001), β ± SE:-1.94 ± 0.13 (p-value &lt; 0.001), and β ± SE:-4.43 ± 0.14 (p-value &lt; 0.001), respectively, and was associated with: BADL (OR = 0.57; 95 %CI: 0.46–0.69), IADL (OR = 0.70; 95 %CI: 0.66–0.75), poor physical performance (SPPB &lt; 7) (OR = 0.68; 95 %CI: 0.64–0.73), Fried's frailty phenotype (OR = 0.72; 95 % CI: 0.68–0.76), hospitalization (OR = 0.96; 95 %CI: 0.93–0.99), and falls' number (OR = 0.96; 95 %CI: 0.92–0.99). Whereas higher SMFD scores were negatively associated with Parkinson's disease, stroke, and hip osteoarthritis.</div><div>The SMFD score is a valid, multidimensional measure that predicts adverse outcomes in older adults. It holds promise for use in clinical assessment, risk stratification, and targeted interventions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113018"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated intermittent theta burst stimulation combined with cognitive training modulates cortical plasticity and brain activation in patients with amnestic mild cognitive impairment","authors":"Jiali Luo ,&nbsp;Zefeng Tan ,&nbsp;Pan Shang ,&nbsp;Shuyun Huang ,&nbsp;Yajing Liu ,&nbsp;Yukai Wang ,&nbsp;Haiqun Xie ,&nbsp;Qi Chen","doi":"10.1016/j.exger.2025.113009","DOIUrl":"10.1016/j.exger.2025.113009","url":null,"abstract":"<div><div>Amnestic mild cognitive impairment (aMCI) is the prodromal period of Alzheimer's disease without effective treatment. This research aimed to investigate the effects of accelerated intermittent theta burst stimulation (iTBS) combined with adaptive cognitive training (COG) on cognitive function in aMCI patients and explore the underlying neural mechanisms. Twenty-four aMCI patients participated in either the real (<em>n</em> = 12) or sham (n = 12) stimulation group. Both groups received adaptive COG, which comprised three sessions of real or sham iTBS delivered on the left dorsolateral prefrontal cortex (DLPFC) once a day for 14 days. The primary outcomes were the Montreal Cognitive Assessment (MoCA) and Alzheimer's Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) scores. Secondary outcomes were changes in cortical plasticity measured by transcranial magnetic stimulation and brain activation monitored by functional near-infrared spectroscopy (fNIRS). Patients were evaluated before and after the intervention. Patients with aMCI who received iTBS combined with COG had a significant improvement in cognitive performance, as assessed by the ADAS-Cog and N-back. In the iTBS+COG group, cortical plasticity measured 30 min post-intervention correlated with ADAS-Cog changes (<em>r</em> = −0.59, <em>p</em> = 0.043). Furthermore, this plasticity was associated with 1-back activation (<em>r</em> = −0.58, <em>p</em> = 0.050), and 2-back activation correlated with ADAS-Cog changes (r = −0.59, <em>p</em> = 0.042). Accelerated iTBS targeted to the left DLPFC combined with adaptive COG promoted cognitive improvement in aMCI patients more effectively by modulating cortical plasticity and brain activation. Cortical plasticity and brain activation might be valuable measurements for understanding cognitive function (Chinese Clinical Trial Registry: ChiCTR2400087943).</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113009"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of adapted tango dance on cognitive and executive function in older adults: A randomized controlled trial","authors":"Yuexin Zhang ,&nbsp;Hongli Zhang ,&nbsp;Hongtao Ma","doi":"10.1016/j.exger.2025.113012","DOIUrl":"10.1016/j.exger.2025.113012","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to evaluate the effects of a 12-week adapted tango program on executive and cognitive function in older adults.</div></div><div><h3>Methods</h3><div>In this randomized controlled trial, fifty Chinese older adults (aged 60–69 years) were randomly assigned to either an adapted tango intervention group (<em>n</em> = 25) or a control group (n = 25) maintaining usual daily habits. The intervention group completed a 12-week adapted tango program (twice weekly, 60 min per session). Executive function was assessed using the Flanker task, Dimensional Change Card Sort (DCCS) task, and N-back task, while global cognition was measured with the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). A two-way repeated-measures ANOVA was performed to examine group × time interactions, followed by Bonferroni-adjusted post-hoc comparisons. Effect sizes were calculated using Cohen's d.</div></div><div><h3>Results</h3><div>Significant group × time interactions were found for Flanker reaction time (RT) and accuracy (<em>p</em> = 0.002 and <em>p</em> &lt; 0.001), with improvements in the tango group but no changes in the control group. DCCS RT and accuracy also showed significant improvements (<em>p</em> &lt; 0.001), while the control group exhibited no changes. Significant improvements were noted in N-back RT and accuracy (<em>p</em> = 0.008 and <em>p</em> &lt; 0.001), with no changes observed in the control group. Additionally, MMSE total and subdomains (e.g., orientation) significantly improved (<em>p</em> &lt; 0.001), with no changes in the controls. MoCA total and subdomains (e.g., visuospatial/executive) significantly improved (<em>p</em> &lt; 0.001), while no changes were found in the control group.</div></div><div><h3>Conclusion</h3><div>The findings suggest that adapted tango may be an effective non-pharmacological intervention for enhancing executive and cognitive functions in older adults, with potential implications for promoting cognitive health in aging populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113012"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing recovery after a hip fracture: Protocol of a randomized controlled trial to study the effects, costs, and cost-effectiveness of a combined protein and exercise intervention in older adults after a hip fracture (ProBUS study)","authors":"Emma Treijtel ,&nbsp;Hugo H. Wijnen ,&nbsp;Nienke M.S. Golüke ,&nbsp;Marian A.E. de van der Schueren ,&nbsp;Lisette C.P.G.M. de Groot ,&nbsp;Inge Groenendijk","doi":"10.1016/j.exger.2025.112999","DOIUrl":"10.1016/j.exger.2025.112999","url":null,"abstract":"<div><h3>Background</h3><div>Hip fractures are common among older adults and typically occur alongside accumulating comorbidities and age-related musculoskeletal decline. While nutritional or exercise interventions can support recovery, the effect of a combined approach during rehabilitation remains unclear. This study aims to evaluate the effects, costs, and cost-effectiveness of a high-protein diet plus exercise intervention on functional recovery after a hip fracture.</div></div><div><h3>Methods</h3><div>This randomized controlled trial will include 102 older adults (≥65 years) recovering in a rehabilitation centre after a hip fracture. Participants will be randomly assigned (1:1) to the intervention or control group, stratified by sex and hospital. The intervention group will receive weekly dietitian support to comply with a high-protein diet (≥1.2 g/kg body weight/day) and will participate in progressive resistance exercise training twice weekly for 3 months. The control group will receive usual care. Due to the nature of the intervention, participant and staff blinding is not feasible, but analyses will be performed blinded. Measurements will be performed in the first week after surgery, at rehabilitation discharge, and 3 months after baseline. The primary outcome is physical functioning using the Short Physical Performance Battery. Secondary outcomes include handgrip strength, muscle mass, bone density, quality of life, daily functioning, nutritional status, bone metabolism biomarkers, and costs.</div></div><div><h3>Discussion</h3><div>The intervention is expected to enhance recovery, attenuate postoperative bone and muscle loss, and improve quality of life. Implementation into standard care could improve efficiency and cost-effectiveness.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112999"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex relationships among various domains of intrinsic capacity and their associated factors in community-dwelling older adults: A network analysis","authors":"Tianle Zou ,&nbsp;Jialin Liu ,&nbsp;Li Zhang ,&nbsp;Fang Liu ,&nbsp;Enming Zhang ,&nbsp;Xiaolong Wang ,&nbsp;Jun Ju ,&nbsp;Xiuxiu Huang ,&nbsp;Qiong Fang","doi":"10.1016/j.exger.2025.113020","DOIUrl":"10.1016/j.exger.2025.113020","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to adopt the network analysis approach to elucidate the complex associations among various domains of intrinsic capacity (IC) and the factors contributing to IC impairments among community-dwelling older adults based on the health ecological model.</div></div><div><h3>Methods</h3><div>A cross-sectional design was adopted, and older adults were recruited from local community health centers. IC was assessed using standardized tools recommended by the World Health Organization. The potential influencing factors of IC were collected based on the health ecological model, including personal characteristics, behavioral lifestyles, interpersonal networks, and living and working conditions. Network analyses were performed using a mixed graphical model to explore the complex relationships among IC domains and their associated factors.</div></div><div><h3>Results</h3><div>Among 3398 eligible participants, 2634 (77.52 %) individuals showed IC impairment, including mobility impairment (46.60 %), cognition impairment (39.38 %) and sensory impairment (35.00 %). Cognition and mobility functions were strongly interrelated (<em>r</em> = 0.24). The predictability values for IC domains were 27.7 % for cognition, 22.9 % for mobility, 15.4 % for psychology, 8.0 % for vitality and 7.5 % for sensory function. Education, age, monthly income, and the number of comorbidities showed close correlations with multiple IC domains. Furthermore, cognition showed specific positive links with lifestyles involving more mental engagement and intellectual work. Mobility was particularly associated with physical activity, including leisure time and household physical activities. Psychological capacity showed a specific association with sleep quality.</div></div><div><h3>Conclusions</h3><div>IC, particularly in the domains of cognition and mobility, was prevalently impaired among older adults. We identified both common and domain-specific factors associated with IC, offering insights for developing targeted interventions to enhance IC.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113020"},"PeriodicalIF":4.3,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}