Metabolism open最新文献_第9页

Effects of fructose added to an oral glucose tolerance test on plasma glucose excursions in healthy adults 口服葡萄糖耐量试验中添加果糖对健康成年人血糖偏移的影响

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100245

Amée M. Buziau , Jean L.J.M. Scheijen , Coen D.A. Stehouwer , Casper G. Schalkwijk , Martijn C.G.J. Brouwers

Background and objective

Previous experimental studies have shown that fructose interacts with glucose metabolism by increasing hepatic glucose uptake. However, human studies investigating the effects of small (‘catalytic’) amounts of fructose, added to an oral glucose load, on plasma glucose levels remain inconclusive. The aim of this study, therefore, was to repeat and extend these previous studies by examining the plasma glucose response during a 75 g oral glucose tolerance test (OGTT) with the addition of different doses of fructose.

Methods

Healthy adults (n = 13) received an OGTT without addition of fructose and OGTTs with addition of different doses of fructose (1, 2, 5, 7.5 and 15 g) in a random order, on six separate occasions. Plasma glucose levels were measured every 15 min for 120 min during the study.

Findings

The plasma glucose incremental area under the curve (iAUC) of the OGTT without addition of fructose was not significantly different from any OGTT with fructose (p ≥ 0.2 for all fructose doses). Similar results were observed when these data were clustered with data from a similar, previous study (pooled mean difference: 10.6; 95%CI: 45.0; 23.8 for plasma glucose iAUC of the OGTT without addition of fructose versus an OGTT with 5 g fructose; fixed-effect meta-analysis, n = 38). Of interest, serum fructose increased from 4.8 μmol/L (interquartile range: 4.1–5.9) at baseline to 5.3 μmol/L (interquartile range: 4.8–7.5) at T = 60 min during an OGTT without addition of fructose (p = 0.002).

Conclusion

Low doses of fructose added to an OGTT do not affect plasma glucose levels in healthy adults. The role of endogenous fructose production, as a potential explanation of these null-findings, deserves further investigation.

背景与目的先前的实验研究表明，果糖通过增加肝脏葡萄糖摄取与葡萄糖代谢相互作用。然而，研究口服葡萄糖负荷中添加少量（“催化”）果糖对血糖水平影响的人体研究仍然没有定论。因此，本研究的目的是通过检测添加不同剂量果糖的75g口服葡萄糖耐量试验（OGTT）期间的血糖反应，重复和扩展这些先前的研究。方法健康成人（n=13）在6个不同的场合随机接受不添加果糖的OGTT和添加不同剂量果糖（1、2、5、7.5和15g）的OGTT。在研究期间，每15分钟测量一次血糖水平，持续120分钟。结果未添加果糖的OGTT的血糖曲线下增加面积（iAUC）与任何添加果糖的OGTT没有显著差异（所有果糖剂量的p≥0.2）。当这些数据与以前类似研究的数据进行聚类时，观察到了类似的结果（合并平均差异：10.6；95%可信区间：45.0；不添加果糖的OGTT与含5g果糖的OGTT的血糖iAUC为23.8；固定效应荟萃分析，n=38）。值得注意的是，在不添加果糖的OGTT中，血清果糖从基线时的4.8μmol/L（四分位间距：4.1-5.9）增加到T=60分钟时的5.3μmol/L（四分位间距，4.8-7.5）（p=0.002）。结论低剂量的果糖添加到OGTT中不会影响健康成年人的血糖水平。内源性果糖生产的作用，作为这些无效发现的潜在解释，值得进一步研究。

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引用次数: 0

Association between personality traits and glycemic control after inpatient diabetes education 住院糖尿病教育后人格特征与血糖控制的关系

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100244

Taisuke Uchida , Hiroaki Ueno , Ayaka Konagata , Takayuki Nakamura , Norifumi Taniguchi , Hiroki Nabekura , Fumiko Kogo , Yuma Nagatomo , Yuri Tanaka , Koichiro Shimizu , Tomomi Shiiya , Hideki Yamaguchi , Kazuya Shimoda

Aims

The longitudinal effect of personality traits on glycemic control is unclear. This prospective observational study explored the relationship between personality traits and glycemic control in patients with uncontrolled diabetes after inpatient diabetes education.

Methods

Patients with diabetes mellitus (HbA1c ≥ 7.5%, measured by high-performance liquid chromatography) who received inpatient diabetes education were scored on the Big Five personality traits: neuroticism, extraversion, openness, agreeableness, and conscientiousness. Multiple linear analysis was used to determine whether any personality traits were independently associated with HbA1c on admission and HbA1c change from admission to 1, 3, and 6 months after discharge.

Results

One hundred seventeen participants (mean age 60.4 ± 14.5 years; 59.0% male) were enrolled. HbA1c values on admission and 1, 3, and 6 months after discharge were 10.2 ± 2.1%, 8.3 ± 1.4%, 7.6 ± 1.4%, and 7.7 ± 1.5%, respectively. Multiple linear analysis showed that no personality traits were associated with HbA1c on admission. Neuroticism was negatively associated with the HbA1c change from admission to 3 months (β = −0.192, P = 0.025) and 6 months after discharge (β = −0.164, P = 0.043).

Conclusions

Neuroticism was associated with good long-term glycemic control after inpatient diabetes education.

人格特征对血糖控制的纵向影响尚不清楚。这项前瞻性观察性研究探讨了住院糖尿病教育后未控制糖尿病患者的人格特征与血糖控制之间的关系。方法对接受住院糖尿病教育的糖尿病患者（HbA1c≥7.5%，高效液相色谱法测定）进行神经质、外向性、开放性、宜人性、责任心五大人格特征评分。使用多元线性分析来确定是否有任何人格特征与入院时的HbA1c以及从入院到出院后1、3和6个月的HbA1c变化独立相关。结果117名参与者（平均年龄60.4±14.5岁；59.0%为男性）被纳入研究。入院时和出院后1、3和6个月的HbA1c值分别为10.2±2.1%、8.3±1.4%、7.6±1.4%和7.7±1.5%。多元线性分析显示，入院时没有任何人格特征与HbA1c相关。从入院到出院3个月（β=-0.192，P=0.025）和6个月（α=-0.164，P=0.043），神经质与HbA1c变化呈负相关。结论糖尿病住院教育后，神经质与良好的长期血糖控制有关。

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引用次数: 0

Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from Artemisia annua on acetaminophen and carbon tetrachloride-induced cytotoxicity in primary mice hepatocytes 青蒿琥酯和青蒿黄酮对对对乙酰氨基酚和四氯化碳诱导的原代小鼠肝细胞毒性的保护作用比较

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100241

Marie Ange Djeungoue Petga , Arnaud Fondjo Kouam , Rosine Désirée Chougouo Kengne , Boris Rosnay Galani Tietcheu , Josué Simo Louokdom , Claude Bérenger Ngantchouko Ngalemo , Pascal Dieudonné Chuisseu Djamen , Paul Fewou Moundipa

Background

Artesunate (ART) is a semi-synthetized molecule from Artemisinin, an active compound isolated from the medicinal plant Artemisia annua, widely used for the treatment of malaria. Previous studies reported that ART may exert a dual effect on the liver. Accordingly, this study investigated the potential protective action of ART against Acetaminophen (APAP) and Carbon tetrachloride (CCl₄)-induced hepatotoxicity in primary mice hepatocytes, in comparison to that of flavonoid extracted from A. annua (FAA). In addition, the antioxidant properties of FAA were also assessed.

Methods

The antioxidant activities of FAA and Ascorbic acid (ASC) (0.01–100 μg/mL) were assessed through inhibition of lipid peroxidation, reduction of ferric and phosphomolydenum, and hydroxyl and DPPH radicals scavenging assays. The hepatoprotective effects of FAA and ART (0.1–100 μg/mL) were evaluated against APAP (11 mM) or CCl4 (4 mM) induced oxidative damage in primary mouse hepatocytes. Biochemical parameters associated with hepatotoxicity assessed include cell viability, cell membrane integrity, cellular glutathione, and antioxidant enzyme activities.

Results

The obtained finding revealed FAA displayed a remarkable antioxidant activities as evidenced by the low IC₅₀/EC₅₀ values (3.85–19.32 μg/mL), comparable to that of ASC (3.26–18.04 μg/mL). When tested at 10 μg/mL, both FAA and ART significantly (p˂0.05) preserved cell viability, inhibited alanine aminotransferase leakage and lipid membrane peroxidation, and restored superoxide dismutase and catalase activities and glutathione content induced by APAP or CCl₄ in a similar way as Silymarin. However, ART showed a significant (p˂0.05) cytotoxic effect on hepatocytes at 100 and 1000 μg/mL and did not confer obvious protection at 100 μg/mL.

Conclusion

Overall, our data demonstrated that ART harms mice hepatocytes at high concentration while conferring relative protection against APAP and CCl₄-hepatotoxicity at low concentration. In contrast, FAA effectively protects liver cells without cytotoxicity effect, event at 100 μg/mL. Accordingly, ART should be given to the patient only under a medical prescription.

背景青蒿素（ART）是从药用植物青蒿中分离得到的一种活性化合物青蒿素的半合成分子，广泛用于治疗疟疾。先前的研究报道，抗逆转录病毒疗法可能对肝脏产生双重作用。因此，本研究研究研究了ART对对乙酰氨基酚（APAP）和四氯化碳（CCl4）诱导的原代小鼠肝细胞肝毒性的潜在保护作用，并与从A.annua中提取的类黄酮（FAA）进行了比较。此外，还对FAA的抗氧化性能进行了评价。方法通过抑制脂质过氧化、还原铁和磷钼以及清除羟基和DPPH自由基的方法，评价FAA和抗坏血酸（ASC）（0.01–100μg/mL）的抗氧化活性。评估了FAA和ART（0.1–100μg/mL）对APAP（11 mM）或CCl4（4 mM）诱导的原代小鼠肝细胞氧化损伤的肝保护作用。评估的与肝毒性相关的生化参数包括细胞活力、细胞膜完整性、细胞谷胱甘肽和抗氧化酶活性。结果FAA表现出显著的抗氧化活性，其IC50/EC50值较低（3.85–19.32μg/mL），与ASC（3.26–18.04μg/mL，并以与水飞蓟素类似的方式恢复APAP或CCl4诱导的超氧化物歧化酶和过氧化氢酶活性以及谷胱甘肽含量。然而，ART在100和1000μg/mL时对肝细胞显示出显著的细胞毒性作用（p 0.05），在100μg/mL下没有提供明显的保护。总之，我们的数据表明，ART在高浓度下对小鼠肝细胞有害，而在低浓度下对APAP和CCl4的肝毒性具有相对的保护作用。相反，FAA在100μg/mL时有效保护肝细胞，没有细胞毒性作用。因此，抗逆转录病毒疗法只能在开具处方的情况下给予患者。

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引用次数: 0

Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications 糖尿病肾病中的铁下垂：机制和治疗意义

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100243

Misganaw Asmamaw Mengstie , Mohammed Abdu Seid , Natnael Atnafu Gebeyehu , Getachew Asmare Adella , Gizchew Ambaw Kassie , Wubet Alebachew Bayih , Molalegn Mesele Gesese , Denekew Tenaw Anley , Sefineh Fenta Feleke , Melkamu Aderajew Zemene , Anteneh Mengist Dessie , Yenealem Solomon , Berihun Bantie , Tadesse Asmamaw Dejenie , Assefa Agegnehu Teshome , Endeshaw Chekol Abebe

Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.

糖尿病肾病（DN）是糖尿病最常见的并发症，长期以来一直影响着糖尿病患者的生活。大量研究表明脱铁性贫血与肾细胞损伤之间存在牢不可破的联系。脱铁症是一种铁依赖性、非凋亡、受调控的细胞死亡，其特征是细胞内脂质过氧化物积累到致命水平。尽管程序性细胞死亡（如凋亡、自噬和坏死）在DN发病机制中的作用已得到证实，但脱铁性贫血在DN中的意义却很少受到质疑。因此，本综述的主要目的是讨论目前对脱铁性贫血的理解，重点是其潜在机制、与DN的关系以及新出现的治疗机会。

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引用次数: 2

Energetic homeostasis achieved through biophoton energy and accompanying medication treatment resulted in sustained levels of Thyroiditis-Hashimoto's, iron, vitamin D & vitamin B12 通过生物光子能量和伴随的药物治疗实现的能量稳态导致桥本甲状腺炎、铁、维生素D和维生素B12的持续水平

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100248

Mariola A. Smotrys , James Z. Liu , Suzanne Street , Seth Robinson

We present the case of a 37-year-old premenopausal woman, who presented with fatigue, weakness, pallor, and myalgias. She was on treatment for Hashimoto's Thyroiditis, iron deficiency anemia, deficiency of vitamin D and B12. Further diagnostic workup revealed her anemia was attributed to a long history of menorrhagia, deficiency of vitamin D and B12 which was attributed to Celiac disease. Her overall health improved with daily medication and by being around the biophoton generators, a device-generated biophoton field. Supplemental exposure to biophoton energy stabilized her blood component levels and improved the functional and energetic conditions of all her organs and systems.

我们报告了一例37岁的绝经前妇女，她表现为疲劳、虚弱、苍白和肌痛。她正在接受桥本甲状腺炎、缺铁性贫血、维生素D和B12缺乏症的治疗。进一步的诊断检查显示，她的贫血归因于长期月经过多、维生素D和B12缺乏，这归因于腹腔疾病。通过每天的药物治疗和生物光子发生器（一种由设备产生的生物光子场），她的整体健康状况有所改善。补充暴露于生物光子能量可以稳定她的血液成分水平，改善她所有器官和系统的功能和能量状况。

引用次数: 0

SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation 人类脂肪细胞中SENP2的敲低降低了葡萄糖代谢和脂质积累，同时增加了脂质氧化

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100234

Solveig A. Krapf , Jenny Lund , Hege G. Bakke , Tuula A. Nyman , Stefano Bartesaghi , Xiao-Rong Peng , Arild C. Rustan , G. Hege Thoresen , Eili T. Kase

Adipose tissue is one of the main regulative sites for energy metabolism. Excess lipid storage and expansion of white adipose tissue (WAT) is the primary contributor to obesity, a strong predisposing factor for development of insulin resistance. Sentrin-specific protease (SENP) 2 has been shown to play a role in metabolism in murine fat and skeletal muscle cells, and we have previously demonstrated its role in energy metabolism of human skeletal muscle cells. In the present work, we have investigated the impact of SENP2 on fatty acid and glucose metabolism in primary human fat cells by using cultured primary human adipocytes to knock down the SENP2 gene. Glucose uptake and oxidation, as well as accumulation and distribution of oleic acid into complex lipids were decreased, while oleic acid oxidation was increased in SENP2-knockdown cells compared to control adipocytes. Furthermore, lipogenesis was reduced by SENP2-knockdown in adipocytes. Although TAG accumulation relative to total uptake was unchanged, there was increased mRNA expression of metabolically relevant genes such as UCP1 and PPARGC1A and mRNA and proteomic data revealed increased levels of mRNA and proteins related to mitochondrial function by SENP2-knockdown. In conclusion, SENP2 is an important regulator of energy metabolism in primary human adipocytes and its knockdown reduce glucose metabolism and lipid accumulation, while increasing lipid oxidation in human adipocytes.

脂肪组织是能量代谢的主要调节部位之一。过量的脂质储存和白色脂肪组织（WAT）的扩张是肥胖的主要原因，肥胖是胰岛素抵抗的一个重要诱发因素。Sentrin特异性蛋白酶（SENP）2已被证明在小鼠脂肪和骨骼肌细胞的代谢中发挥作用，我们之前已经证明了它在人类骨骼肌细胞能量代谢中的作用。在本工作中，我们通过使用培养的原代人类脂肪细胞敲除SENP2基因，研究了SENP2对原代人类脂细胞中脂肪酸和葡萄糖代谢的影响。与对照脂肪细胞相比，SENP2敲低细胞中的葡萄糖摄取和氧化以及油酸在复杂脂质中的积累和分布减少，而油酸氧化增加。此外，脂肪细胞中SENP2的敲除降低了脂肪生成。尽管TAG的积累相对于总摄取没有变化，但代谢相关基因（如UCP1和PPARGC1A）的mRNA表达增加，并且蛋白质组学数据显示，通过SENP2敲低，与线粒体功能相关的mRNA和蛋白质水平增加。总之，SENP2是原代人类脂肪细胞能量代谢的重要调节因子，其敲低可减少葡萄糖代谢和脂质积累，同时增加人类脂肪细胞中的脂质氧化。

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引用次数: 0

Differential metabolic host response to pathogens associated with community-acquired pneumonia 不同代谢宿主对社区获得性肺炎相关病原体的反应

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100239

Ilona den Hartog , Naama Karu , Laura B. Zwep , G. Paul Voorn , Ewoudt M.W. van de Garde , Thomas Hankemeier , J.G. Coen van Hasselt

Background

Metabolic changes induced by the host immune response to pathogens found in patients with community-acquired pneumonia (CAP) may provide insight into its pathogenesis. In this study, we characterized differences in the host metabolic response to common CAP-associated pathogens.

Method

Targeted metabolomic profiling was performed on serum samples obtained from hospitalized CAP patients (n = 119) at admission. We quantified 347 unique metabolites across multiple biochemical classes, including amines, acylcarnitines, and signaling lipids. We evaluated if unique associations between metabolite levels and specific CAP-associated pathogens could be identified.

Results

Several acylcarnitines were found to be elevated in C. burnetii and herpes simplex virus and lowered in M. pneumoniae as compared to other pathogens. Phenylalanine and kynurenine were found elevated in L. pneumophila as compared to other pathogens. S-methylcysteine was elevated in patients with M. pneumoniae, and these patients also showed lowered cortisol levels in comparison to almost all other pathogens. For the herpes simplex virus, we observed a unique elevation of eicosanoids and several amines. Many lysophosphatidylcholines showed an altered profile in C. burnetii versus S. pneumoniae, L. pneumophila, and respiratory syncytial virus. Finally, phosphatidylcholines were negatively affected by the influenza virus in comparison to S. pneumoniae.

Conclusions

In this exploratory analysis, metabolites from different biochemical classes were found to be altered in serum samples from patients with different CAP-associated pathogens, which may be used for hypothesis generation in studies on differences in pathogen host response and pathogenesis of CAP.

背景宿主对社区获得性肺炎（CAP）患者病原体的免疫反应引起的代谢变化可能为其发病机制提供线索。在这项研究中，我们描述了宿主对常见CAP相关病原体代谢反应的差异。方法对住院CAP患者（n=119）入院时的血清样本进行靶向代谢组学分析。我们量化了多种生物化学类别的347种独特代谢物，包括胺、酰基肉毒碱和信号脂质。我们评估了代谢物水平和特定CAP相关病原体之间的独特相关性是否可以确定。结果与其他病原体相比，烧伤杆菌和单纯疱疹病毒中的一些酰基肉毒碱升高，肺炎支原体中的酰基肉毒素降低。与其他病原体相比，嗜肺乳杆菌中的苯丙氨酸和犬尿氨酸含量升高。肺炎支原体患者的S-甲基半胱氨酸升高，与几乎所有其他病原体相比，这些患者的皮质醇水平也降低。对于单纯疱疹病毒，我们观察到类二十烷和几种胺的独特升高。与肺炎链球菌、嗜肺链球菌和呼吸道合胞病毒相比，许多溶血磷脂酰胆碱在burnetii中表现出变化。最后，与肺炎链球菌相比，磷脂酰胆碱受到流感病毒的负面影响。结论在本次探索性分析中，发现不同CAP相关病原体患者血清样本中不同生化类别的代谢产物发生了改变，这可用于研究CAP病原体-宿主反应差异和发病机制的假设生成。

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引用次数: 0

Glycemic control and its association with sleep quality and duration among type 2 diabetic patients 2型糖尿病患者血糖控制及其与睡眠质量和持续时间的关系

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100246

Yadelew Yimer Shibabaw , Tadesse Asmamaw Dejenie , Kibur Hunie Tesfa

Background

Poor glycemic control is the current most important tragedy in type 2 diabetic patients. Sleep has a major modulatory effect on endocrine and metabolic function. Sleep disturbance is associated with increased circulating cortisol levels, sympathetic activity, and epinephrine secretion. These physiological conditions are directly or indirectly associated with glucose metabolism in our body cells. In Ethiopia, sleep pattern association with glycemic control level is not studied yet.

Objectives

To assess glycemic control and its association with sleep quality, sleep duration and napping among patients with type 2 diabetes mellitus in Felege Hiwot Comprehensive Referral and Specialized Hospital Northwest Ethiopia.

Method

An institutional-based cross-sectional study was conducted among 407 type 2 diabetes mellitus patients from July 1, 2020, to April 28, 2021, using a systematic random sampling technique. We drew 5 mL of blood from each patient before breakfast to determine their fasting blood sugar level. The Pittsburg Sleep Quality Index was used to assess patients' sleep quality, and the presence or absence of Obstructive Sleep Apnea was determined using the STOP-BANG questionnaire. Data were analysed using STATA version 14.1.variables with a P-value of <0.05 were considered statistically significant.

Results

Glycemic control was found to be poor in 54.05% of the study participants. Female sex, poor sleep quality, and short and long sleep durations were all significantly associated with impaired glycemic control. Being female increased the odds of poor glycemic control by 2.7 times (AOR = 2.7, 95% CI: 1.23, 6.15) compared to males. T2DM patients who had poor sleep quality had 3.3 times (AOR = 3.3, 95% CI (1.16, 9.37) higher odds of poor glycemic control compared to patients who had good sleep quality. The odds of having poor glycemic control among T2DM patients who were at low risk of OSA and intermediate risk of OSA were decreased by 96% (AOR = 0.03, 95% CI: 0.01, 0.12) and 86% (AOR = 0.14, 95% CI: 0.05, 0.43) compared to T2DM patients who were at high risk of OSA, respectively. T2DM patients who had short sleep duration (<6 hours) were 8.3 times (AOR = 8.3, 95% CI: 2.66–25.85) higher chances of poor glycemic control compared to patients who had average sleep duration. T2DM patients who had long sleep duration (>8 hours) increased the odds of poor glycemic control by 2.6 times (AOR = 2.6, 95% CI (1.12–6.04) compared to those who had average sleep duration. The chances of having poor glycemic control among T2DM patients who did not take the balanced diet recommended by their physician were increased by 3.8 times (AOR = 3.8 95% CI: 1.05–13.77).

Conclusion

The prevalence of poor glycemic control in T2DM patients was high. Poor sleep quality, both short and long sleep duration, and an intermediate or low risk of obstr

背景血糖控制不佳是目前2型糖尿病患者最严重的悲剧。睡眠对内分泌和代谢功能有重要的调节作用。睡眠障碍与循环皮质醇水平、交感神经活动和肾上腺素分泌增加有关。这些生理条件与我们身体细胞中的葡萄糖代谢直接或间接相关。在埃塞俄比亚，睡眠模式与血糖控制水平的关系尚未得到研究。目的评估埃塞俄比亚西北Felege Hiwot综合转诊和专科医院2型糖尿病患者的血糖控制及其与睡眠质量、睡眠时间和打盹的关系，使用系统随机采样技术。我们在早餐前从每位患者身上抽取5毫升血液，以确定他们的空腹血糖水平。匹兹堡睡眠质量指数用于评估患者的睡眠质量，并使用STOP-BANG问卷确定是否存在阻塞性睡眠呼吸暂停。使用具有<；0.05被认为具有统计学意义。结果54.05%的受试者血糖控制不佳。女性、睡眠质量差、睡眠时间长短都与血糖控制受损显著相关。与男性相比，女性血糖控制不佳的几率增加了2.7倍（AOR=2.7，95%CI:1.236.15）。睡眠质量差的T2DM患者血糖控制不佳的几率是睡眠质量好的患者的3.3倍（AOR=3.3，95%CI（1.16，9.37）。与OSA高风险的T2DM患者相比，OSA低风险和OSA中风险的T2糖尿病患者血糖控制不佳的几率分别降低了96%（AOR=0.03，95%CI:0.012.12）和86%（AOR=0.14，95%CI:0.05,0.43）。与睡眠时间平均的患者相比，睡眠时间短（＜6小时）的T2DM患者血糖控制不佳的几率高8.3倍（AOR=8.3，95%CI:2.66-25.85）。睡眠时间长（>；8小时）的T2DM患者与睡眠时间平均的患者相比，血糖控制不佳的几率增加了2.6倍（AOR=2.6，95%CI（1.12–6.04）。不采用医生推荐的均衡饮食的T2DM患者血糖控制不良的几率增加了3.8倍（AOR=3.895%CI:1.05-13.77）。结论T2DM患者的血糖控制不良发生率较高。睡眠质量差、睡眠时间短和长以及阻塞性睡眠呼吸暂停的中等或低风险在统计学上与血糖控制差相关。因此，建议良好的睡眠质量和适当的睡眠时间，以将血糖控制水平保持在正常范围内。

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引用次数: 0

Global prevalence of sexual dysfunction among diabetic patients from 2008 to 2022: Systematic review and meta-analysis 2008年至2022年糖尿病患者性功能障碍的全球患病率：系统综述和荟萃分析

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100247

Natnael Atnafu Gebeyehu , Molalegn Melese Gesese , Kirubel Dagnaw Tegegne , Yenalem Solomon Kebede , Gizachew Ambaw Kassie , Misganaw Asmamaw Mengstie , Melkamu Aderajaw Zemene , Berihun Bantie , Sefineh Fenta Feleke , Tadesse Asmamaw Dejenie , Endeshaw Chekol Abebe , Denekew Tenaw Anley , Anteneh Mengist Dessie , Wubet Alebachew Bayih , Getachew Asmare Adela

Background

Both men and women can have a wide range of physical, emotional, and sexual issues as a result of diabetes. One of them is sexual dysfunction, which has an effect on marital relationships as well as the effectiveness of therapy and can develop into a serious social and psychological condition. As a result, the purpose of this study was to identify the global prevalence of sexual dysfunction among diabetic patients.

Methods

Science Direct, Scopus, Google Scholar, and PubMed were all searched for information. Data were extracted using Microsoft Excel (v. 14), STATA statistical software, and STATA. Publication bias was investigated by a forest plot, rank test, and Egger's regression test. To detect heterogeneity, I² was calculated and an overall estimated analysis was performed. Subgroup analysis was done by study region and sample size. The pooled odds ratio was also computed.

Results

The study was able to include 15 of the 654 publications that were evaluated since they met the criteria. 67,040 people participated in the survey in all. The pooled global prevalence of sexual dysfunction among diabetic patients was 61.4% (95% CI: 51.80, 70.99), I2 = 71.6%. The frequency of sexual dysfunction was highest in the European region (66.05%). For males, the prevalence of sexual dysfunction was 65.91%, while for females, it was 58.81%. Patients with type 2 diabetes mellitus were more likely (71.03%) to experience sexual dysfunction.

Conclusion

Finally, sexual dysfunction was fairly common all across the world. There were variations in the prevalence of sexual dysfunction depending on the sex, type of diabetes, and location of the study participant. Our findings imply that screening and appropriate treatment are required for diabetes persons exhibiting sexual dysfunction.

背景由于糖尿病，男性和女性都可能有各种各样的身体、情感和性问题。其中之一是性功能障碍，它会影响婚姻关系和治疗的有效性，并可能发展成严重的社会和心理状况。因此，本研究的目的是确定糖尿病患者性功能障碍的全球流行率。方法检索Science Direct、Scopus、Google Scholar和PubMed。使用Microsoft Excel（第14版）、STATA统计软件和STATA提取数据。发表偏倚通过森林图、秩检验和艾格回归检验进行调查。为了检测异质性，计算I2并进行总体估计分析。根据研究区域和样本量进行亚组分析。还计算了合并比值比。结果本研究纳入了654篇符合标准的出版物中的15篇。共有67040人参加了调查。糖尿病患者性功能障碍的综合全球患病率为61.4%（95%可信区间：51.80，70.99），I2=71.6%。性功能障碍的发生率在欧洲地区最高（66.05%）。男性性功能障碍的患病率为65.91%，而女性为58.81%。2型糖尿病患者更有可能（71.03%）发生性功能障碍。结论最后，性功能障碍在世界范围内相当普遍。性功能障碍的发生率因研究参与者的性别、糖尿病类型和地点而异。我们的研究结果表明，对表现出性功能障碍的糖尿病患者需要进行筛查和适当的治疗。

{"title":"Global prevalence of sexual dysfunction among diabetic patients from 2008 to 2022: Systematic review and meta-analysis","authors":"Natnael Atnafu Gebeyehu , Molalegn Melese Gesese , Kirubel Dagnaw Tegegne , Yenalem Solomon Kebede , Gizachew Ambaw Kassie , Misganaw Asmamaw Mengstie , Melkamu Aderajaw Zemene , Berihun Bantie , Sefineh Fenta Feleke , Tadesse Asmamaw Dejenie , Endeshaw Chekol Abebe , Denekew Tenaw Anley , Anteneh Mengist Dessie , Wubet Alebachew Bayih , Getachew Asmare Adela","doi":"10.1016/j.metop.2023.100247","DOIUrl":"10.1016/j.metop.2023.100247","url":null,"abstract":"<div><h3>Background</h3><p>Both men and women can have a wide range of physical, emotional, and sexual issues as a result of diabetes. One of them is sexual dysfunction, which has an effect on marital relationships as well as the effectiveness of therapy and can develop into a serious social and psychological condition. As a result, the purpose of this study was to identify the global prevalence of sexual dysfunction among diabetic patients.</p></div><div><h3>Methods</h3><p>Science Direct, Scopus, Google Scholar, and PubMed were all searched for information. Data were extracted using Microsoft Excel (v. 14), STATA statistical software, and STATA. Publication bias was investigated by a forest plot, rank test, and Egger's regression test. To detect heterogeneity, I<sup>2</sup> was calculated and an overall estimated analysis was performed. Subgroup analysis was done by study region and sample size. The pooled odds ratio was also computed.</p></div><div><h3>Results</h3><p>The study was able to include 15 of the 654 publications that were evaluated since they met the criteria. 67,040 people participated in the survey in all. The pooled global prevalence of sexual dysfunction among diabetic patients was 61.4% (95% CI: 51.80, 70.99), I2 = 71.6%. The frequency of sexual dysfunction was highest in the European region (66.05%). For males, the prevalence of sexual dysfunction was 65.91%, while for females, it was 58.81%. Patients with type 2 diabetes mellitus were more likely (71.03%) to experience sexual dysfunction.</p></div><div><h3>Conclusion</h3><p>Finally, sexual dysfunction was fairly common all across the world. There were variations in the prevalence of sexual dysfunction depending on the sex, type of diabetes, and location of the study participant. Our findings imply that screening and appropriate treatment are required for diabetes persons exhibiting sexual dysfunction.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/f7/main.PMC10267599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men 尼日利亚男性睾酮-雌二醇比值与某些人体测量和代谢参数的关系

Metabolism open

Pub Date : 2023-06-01 DOI: 10.1016/j.metop.2023.100249

Holiness Stephen Adedeji Olasore , Tolulope Adejoke Oyedeji , Matthew Olamide Olawale , Omobolanle Ibukun Ogundele , Joseph Ogo-Oluwa Faleti

Background

Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the ratio of serum testosterone to estradiol levels. Therefore, we investigated the relationship between the testosterone-estradiol (T/E2) ratio, anthropometry, and metabolic parameters in Nigerian men.

Method

Eighty-five adult men were recruited for this study. Participants’ data such as age, weight, height, BMI, and waist circumference were collected. Plasma total testosterone and estradiol levels, as well as metabolic parameters such as fasting blood sugar, creatinine, urea, HDL cholesterol, total cholesterol, and triglycerides levels, were determined. The data were analyzed using SPSS version 25 software.

Results

Anthropometric parameters such as weight, height, BMI, and waist circumference showed a negative correlation with plasma T/E2 (r = −0.265, −0.288, −0.106, −0.204; p = 0.007, 0.004, 0.167, 0.061 respectively). However, the T/E2 ratio showed a positive correlation with the metabolic parameters such as fasting blood sugar, HDL cholesterol levels, plasma creatinine, and urea (r = 0.219, 0.096, 0.992, 0.152; p = 0.022, 0.192, <0.001, 0.082 respectively), while there were negative correlations with total cholesterol and triglycerides levels (r = −0.200, −0.083; p = 0.034, 0.226 respectively).

Conclusion

These findings show that there are significant correlations between the T/E2 ratio and weight, height, fasting blood sugar, creatinine, and urea, while there are no significant correlations between T/E2 ratio and BMI, waist circumference, HDL-cholesterol, and triglycerides.

背景性激素水平的改变与男性代谢过程的调节有关。近年来，尼日利亚肥胖、胰岛素抵抗和2型糖尿病等代谢紊乱的患病率有所上升。在男性中，这些疾病可能与血清睾酮与雌二醇水平的比值有关。因此，我们研究了尼日利亚男性睾酮-雌二醇（T/E2）比值、人体测量和代谢参数之间的关系。方法招募85名成年男性参与本研究。收集参与者的数据，如年龄、体重、身高、BMI和腰围。测定血浆总睾酮和雌二醇水平，以及代谢参数，如空腹血糖、肌酸酐、尿素、高密度脂蛋白胆固醇、总胆固醇和甘油三酯水平。使用SPSS 25版软件对数据进行分析。结果体重、身高、BMI、腰围等人体测量参数与血浆T/E2呈负相关（r分别为-0.265、-0.28、-0.106、-0.204；p分别为0.007、0.004、0.167、0.061）。然而，T/E2比率显示出与代谢参数如空腹血糖、高密度脂蛋白胆固醇水平、血浆肌酸酐和尿素呈正相关（r分别为0.219、0.096、0.992、0.152；p分别为0.022、0.192、<；0.001、0.082），而与总胆固醇和甘油三酯水平呈负相关（r分别为-0.200、-0.083；p分别为0.034、0.226），高密度脂蛋白胆固醇和甘油三酯。

{"title":"Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men","authors":"Holiness Stephen Adedeji Olasore , Tolulope Adejoke Oyedeji , Matthew Olamide Olawale , Omobolanle Ibukun Ogundele , Joseph Ogo-Oluwa Faleti","doi":"10.1016/j.metop.2023.100249","DOIUrl":"10.1016/j.metop.2023.100249","url":null,"abstract":"<div><h3>Background</h3><p>Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the ratio of serum testosterone to estradiol levels. Therefore, we investigated the relationship between the testosterone-estradiol (T/E2) ratio, anthropometry, and metabolic parameters in Nigerian men.</p></div><div><h3>Method</h3><p>Eighty-five adult men were recruited for this study. Participants’ data such as age, weight, height, BMI, and waist circumference were collected. Plasma total testosterone and estradiol levels, as well as metabolic parameters such as fasting blood sugar, creatinine, urea, HDL cholesterol, total cholesterol, and triglycerides levels, were determined. The data were analyzed using SPSS version 25 software.</p></div><div><h3>Results</h3><p>Anthropometric parameters such as weight, height, BMI, and waist circumference showed a negative correlation with plasma T/E2 (r = −0.265, −0.288, −0.106, −0.204; p = 0.007, 0.004, 0.167, 0.061 respectively). However, the T/E2 ratio showed a positive correlation with the metabolic parameters such as fasting blood sugar, HDL cholesterol levels, plasma creatinine, and urea (r = 0.219, 0.096, 0.992, 0.152; p = 0.022, 0.192, <0.001, 0.082 respectively), while there were negative correlations with total cholesterol and triglycerides levels (r = −0.200, −0.083; p = 0.034, 0.226 respectively).</p></div><div><h3>Conclusion</h3><p>These findings show that there are significant correlations between the T/E2 ratio and weight, height, fasting blood sugar, creatinine, and urea, while there are no significant correlations between T/E2 ratio and BMI, waist circumference, HDL-cholesterol, and triglycerides.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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