Nature aging最新文献

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Demystifying the appeal process 揭开上诉程序的神秘面纱。

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-19 DOI: 10.1038/s43587-024-00679-z

Rejections by peer-reviewed journals are frequent, but authors may get a second chance to convince editors and peers by submitting an appeal. Here we explain how we approach appeals at Nature Aging and share some statistics on them to help authors to carefully consider when and how to appeal.

被同行评审期刊拒稿是常有的事，但作者可以通过提交上诉获得第二次说服编辑和同行的机会。在此，我们将解释《自然-衰老》如何处理上诉，并分享一些有关上诉的统计数据，以帮助作者仔细考虑何时以及如何上诉。

引用次数: 0

A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells. 年轻和衰老小鼠血细胞代谢图谱发现尿苷是使衰老造血干细胞恢复活力的代谢物。

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-17 DOI: 10.1038/s43587-024-00669-1

Xiangjun Zeng, Ce Shi, Yingli Han, Kejia Hu, Xiaoqing Li, Cong Wei, Lijuan Ding, Jiazhen Cui, Simao Huang, Yulin Xu, Meng Zhang, Wei Shan, Qian Luo, Jian Yu, Zhongzheng Zheng, Xia Li, Pengxu Qian, He Huang

Aging of hematopoietic stem cells (HSCs) is accompanied by impaired self-renewal ability, myeloid skewing, immunodeficiencies and increased susceptibility to malignancies. Although previous studies highlighted the pivotal roles of individual metabolites in hematopoiesis, comprehensive and high-resolution metabolomic profiles of different hematopoietic cells across ages are still lacking. In this study, we created a metabolome atlas of different blood cells across ages in mice. We reveal here that purine, pyrimidine and retinol metabolism are enriched in young hematopoietic stem and progenitor cells (HSPCs), whereas glutamate and sphingolipid metabolism are concentrated in aged HSPCs. Through metabolic screening, we identified uridine as a potential regulator to rejuvenate aged HSPCs. Mechanistically, uridine treatment upregulates the FoxO signaling pathway and enhances self-renewal while suppressing inflammation in aged HSCs. Finally, we constructed an open-source platform for public easy access and metabolomic analysis in blood cells. Collectively, we provide a resource for metabolic studies in hematopoiesis that can contribute to future anti-aging metabolite screening.

造血干细胞（HSCs）的衰老伴随着自我更新能力受损、髓系偏斜、免疫缺陷和对恶性肿瘤的易感性增加。尽管之前的研究强调了个别代谢物在造血过程中的关键作用，但目前仍缺乏不同年龄段造血细胞的全面、高分辨率代谢组学图谱。在这项研究中，我们绘制了小鼠各年龄段不同血细胞的代谢组图谱。我们在此发现，嘌呤、嘧啶和视黄醇代谢富集于年轻的造血干细胞和祖细胞（HSPCs），而谷氨酸和鞘脂代谢则集中于年老的HSPCs。通过代谢筛选，我们发现尿苷是一种潜在的调节剂，可使衰老的 HSPC 恢复活力。从机理上讲，尿苷处理可上调 FoxO 信号通路，在抑制炎症的同时增强衰老造血干细胞的自我更新能力。最后，我们构建了一个开源平台，方便公众访问并进行血细胞代谢组学分析。总之，我们为造血过程中的代谢研究提供了资源，有助于未来抗衰老代谢物的筛选。

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引用次数: 0

A clinical perspective on the revised criteria for diagnosis and staging of Alzheimer’s disease 从临床角度看阿尔茨海默病诊断和分期的修订标准。

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-15 DOI: 10.1038/s43587-024-00675-3

Oskar Hansson, Clifford R. Jack Jr.

The 2024 update for Alzheimer’s disease (AD) criteria introduces a new biomarker classification system with blood biomarkers and revised staging. AD biomarkers are currently recommended for symptomatic patients within comprehensive clinical evaluations. High-performing p-tau217 assays offer cost-effective diagnostics, comparable to cerebrospinal fluid and PET. International clinical guidelines are being developed to enhance diagnostic and prognostic accuracy. A Comment that discusses how biomarkers might be used in clinical practice to improve the diagnostic work-up of Alzheimer’s disease. It also highlights key knowledge gaps that need addressing before global clinical implementation of such markers.

2024 年更新的阿尔茨海默病（AD）标准引入了新的生物标志物分类系统，包括血液生物标志物和修订的分期。目前建议在综合临床评估中对有症状的患者使用阿兹海默症生物标记物。高效的 p-tau217 检测方法可提供与脑脊液和正电子发射计算机断层显像相媲美的高性价比诊断方法。目前正在制定国际临床指南，以提高诊断和预后的准确性。一篇评论讨论了如何在临床实践中使用生物标记物来改进阿尔茨海默病的诊断工作。评论还强调了在全球临床应用此类标记物之前需要解决的关键知识缺口。

引用次数: 0

Robust immunity conferred by combining COVID-19 vaccine platforms in older adults 结合 COVID-19 疫苗平台为老年人带来强大的免疫力。

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-12 DOI: 10.1038/s43587-024-00668-2

Carolien E. van de Sandt, Katherine Kedzierska

SARS-CoV-2 infections are typically more severe with increased age. Vaccination can reduce morbidity and mortality, but the age-associated decline in immune function could limit vaccine efficacy in older adults. Dallan, Proietto and colleagues demonstrate robust immunological humoral and cellular memory in older adults who received primary vaccinations using the adenoviral platforms and received subsequent boosting with mRNA vaccine platforms.

随着年龄的增长，SARS-CoV-2 感染通常会更加严重。接种疫苗可以降低发病率和死亡率，但与年龄相关的免疫功能下降可能会限制疫苗对老年人的疗效。Dallan、Proietto 及其同事证明，使用腺病毒平台进行初次接种并随后使用 mRNA 疫苗平台进行强化接种的老年人具有强大的免疫体液和细胞记忆能力。

引用次数: 0

Gut microorganisms enhance bone mass after exercise 肠道微生物能增强运动后的骨量

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-10 DOI: 10.1038/s43587-024-00676-2

George Andrew S. Inglis

引用次数: 0

Protein-based risk score improves prediction of hip fractures 基于蛋白质的风险评分可提高对髋部骨折的预测能力

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-10 DOI: 10.1038/s43587-024-00680-6

Identification of patients at risk for hip fracture is crucial to inform intervention strategies. We developed a plasma protein-based risk score for hip fracture and validated this score in three independent cohorts using two substantially different proteomics platforms. The protein-based risk score, but not available polygenic risk scores, improved hip fracture discrimination.

识别髋部骨折风险患者对于制定干预策略至关重要。我们开发了基于血浆蛋白的髋部骨折风险评分，并利用两种截然不同的蛋白质组学平台在三个独立队列中验证了这一评分。基于蛋白质的风险评分（而非现有的多基因风险评分）提高了髋部骨折的辨别能力。

引用次数: 0

Blood protein assessment of leading incident diseases and mortality in the UK Biobank 英国生物库中主要突发疾病和死亡率的血液蛋白评估

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-10 DOI: 10.1038/s43587-024-00655-7

Danni A. Gadd, Robert F. Hillary, Zhana Kuncheva, Tasos Mangelis, Yipeng Cheng, Manju Dissanayake, Romi Admanit, Jake Gagnon, Tinchi Lin, Kyle L. Ferber, Heiko Runz, Biogen Biobank Team, Christopher N. Foley, Riccardo E. Marioni, Benjamin B. Sun

The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age-related diseases and mortality in the UK Biobank (n = 47,600). We report 3,209 associations between 963 protein levels and 21 incident outcomes. Next, protein-based scores (ProteinScores) are developed using penalized Cox regression. When applied to test sets, six ProteinScores improve the area under the curve estimates for the 10-year onset of incident outcomes beyond age, sex and a comprehensive set of 24 lifestyle factors, clinically relevant biomarkers and physical measures. Furthermore, the ProteinScore for type 2 diabetes outperforms a polygenic risk score and HbA1c—a clinical marker used to monitor and diagnose type 2 diabetes. The performance of scores using metabolomic and proteomic features is also compared. These data characterize early proteomic contributions to major age-related diseases, demonstrating the value of the plasma proteome for risk stratification. Gadd et al. identify proteins circulating in the blood that can stratify the risk people have of developing a range of leading age-related diseases, up to a decade before onset.

通过循环蛋白质组可以深入了解疾病的生物学途径。在这里，我们测试了英国生物数据库（n = 47,600）中 1,468 个 Olink 蛋白水平与 23 种年龄相关疾病的发病率和死亡率之间的关系。我们报告了 963 种蛋白质水平与 21 种发病结果之间的 3209 种关联。接下来，我们使用惩罚性 Cox 回归法开发了基于蛋白质的评分（ProteinScores）。当应用于测试集时，有六种蛋白质分数提高了对10年发病结果的曲线下面积估计值，超过了年龄、性别和24种生活方式因素、临床相关生物标志物和物理测量的综合集合。此外，2 型糖尿病蛋白质评分的表现优于多基因风险评分和 HbA1c（用于监测和诊断 2 型糖尿病的临床标志物）。此外，还比较了使用代谢组学和蛋白质组学特征进行评分的性能。这些数据描述了早期蛋白质组对主要老年相关疾病的贡献，证明了血浆蛋白质组在风险分层方面的价值。

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引用次数: 0

Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection 追踪 COVID-19 老年幸存者感染后 2.5 年的认知轨迹

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-10 DOI: 10.1038/s43587-024-00667-3

Yu-Hui Liu, Quan-Xin Wu, Qing-Hua Wang, Qiao-Feng Zhang, Yi Tang, Di Liu, Jing-Juan Wang, Xiao-Yu Liu, Ling-Ru Wang, Li Li, Cheng Xu, Jie Zhu, Yan-Jiang Wang

Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change after a COVID-19 infection remain unclear. Here we investigated cognitive changes over a period of 2.5 years among 1,245 individuals aged 60 years or older who survived infection with the original SARS-CoV-2 strain in Wuhan, China, and 358 uninfected spouses. We show that the overall incidence of cognitive impairment among older COVID-19 survivors was 19.1% at 2.5 years after infection and hospitalization, evaluated using the Telephone Interview for Cognitive Status-40. Cognitive decline primarily manifested in individuals with severe COVID-19 during the initial year of infection, after which the rate of decline decelerated. Severe COVID-19, cognitive impairment at 6 months and hypertension were associated with long-term cognitive decline. These findings reveal the long-term cognitive trajectory of the disease and underscore the importance of post-infection cognitive care for COVID-19 survivors. Tracking cognitive function over 2.5 years following SARS-CoV-2 infection, Liu, Wu, Wang et al. find that cognitive decline in older COVID-19 survivors in Wuhan, China, manifests primarily in the first year following severe COVID-19.

新的证据表明，感染 SARS-CoV-2 后，COVID-19 的神经系统和其他急性后遗症可能会持续存在或发展。然而，COVID-19 感染后认知变化的长期轨迹仍不清楚。在此，我们对在中国武汉感染 SARS-CoV-2 原始毒株后存活下来的 1,245 名 60 岁或以上的患者以及 358 名未受感染的配偶进行了为期 2.5 年的认知变化调查。我们通过认知状况电话访谈-40（Telephone Interview for Cognitive Status-40）评估发现，COVID-19 老年幸存者在感染和住院 2.5 年后认知障碍的总体发生率为 19.1%。认知功能下降主要表现在感染后最初一年的严重 COVID-19 患者身上，此后下降速度减慢。严重的 COVID-19、6 个月时的认知障碍和高血压与长期认知能力下降有关。这些发现揭示了该疾病的长期认知轨迹，并强调了对COVID-19幸存者进行感染后认知护理的重要性。

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引用次数: 0

A distinct aging-enriched platelet differentiation pathway 独特的衰老富集血小板分化途径

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-09 DOI: 10.1038/s43587-024-00677-1

Anna Kriebs

引用次数: 0

Pharmacological TERT activation attenuates phenotypes of natural aging 药物 TERT 激活可减轻自然衰老的表型。

IF 17 Q1 CELL BIOLOGY

Nature aging

Pub Date : 2024-07-08 DOI: 10.1038/s43587-024-00673-5

Hannah Walters

引用次数: 0

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