Objectives: The brown adipose tissue is distributed only in specific locations of the mammalian body. Evidence has been presented that the brown fat occurs in human foetuses and new-borns. At later stages of life, most brown fat cells disappear and only persist in the perirenal and periaortic adipose tissue. However, detailed data on the occurrence of brown adipose tissue in adult humans differ among existing studies.
Design: The aim of this study was to determine the prevalence of brown adipose tissue in adult Slovak population.
Subjects and methods: The samples of periadrenal adipose tissue were taken from 379 consecutive autopsies of subjects aged between 26 and 94 years, fixed in formalin, processed by routine methods and stained with hematoxylin-eosin. The sections were examined by light microscopy.
Results and conclusions: Brown adipose tissue cells were found in 240 (63%) cases. The prevalence of brown adipose tissue decreases below the age of 50 and later slightly increases. No significant differences in the prevalence of brown adipose tissue between men and women were found. With the exception of Germany, this study is currently the first extensive morphological autopsy study of brown adipose tissue prevalence in adults in Central and Eastern Europe.
{"title":"Occurrence of periadrenal brown adipose tissue in adult Slovak population.","authors":"Jozef Sidlo, Peter Kvasnicka, Henrieta Sidlova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The brown adipose tissue is distributed only in specific locations of the mammalian body. Evidence has been presented that the brown fat occurs in human foetuses and new-borns. At later stages of life, most brown fat cells disappear and only persist in the perirenal and periaortic adipose tissue. However, detailed data on the occurrence of brown adipose tissue in adult humans differ among existing studies.</p><p><strong>Design: </strong>The aim of this study was to determine the prevalence of brown adipose tissue in adult Slovak population.</p><p><strong>Subjects and methods: </strong>The samples of periadrenal adipose tissue were taken from 379 consecutive autopsies of subjects aged between 26 and 94 years, fixed in formalin, processed by routine methods and stained with hematoxylin-eosin. The sections were examined by light microscopy.</p><p><strong>Results and conclusions: </strong>Brown adipose tissue cells were found in 240 (63%) cases. The prevalence of brown adipose tissue decreases below the age of 50 and later slightly increases. No significant differences in the prevalence of brown adipose tissue between men and women were found. With the exception of Germany, this study is currently the first extensive morphological autopsy study of brown adipose tissue prevalence in adults in Central and Eastern Europe.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"40 Suppl1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2019-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jozef Sidlo, Jan Sikuta, Henrieta Sidlova, Lubos Niznansky
Objectives: Intentional or unintentional caffeine abuse due to excessive intake of energy beverages is frequent. Fatalities due to caffeine intoxication are presented rarely. Over the last years, cases of caffeine ingestion for purposes of committing suicide have been reported in scientific literature.
Design: The aim of this case study is to report a fatal case of a 26-year-old man who intentionally ingested pure caffeine powder.
Methods: Standard autopsy, microscopic examination and toxicological examination using screening method, TLC, GC, and GC/MS were performed.
Results and conclusions: The presence of caffeine only at the concentration of 362 ug/mL in blood and 187 ug/mL in urine was revealed. The cause of death was cardiac arrest most likely due to ventricular dysrhythmia. The concentration of caffeine determined in the femoral blood of the decedent was three times higher than the lethal concentrations reported in other published case studies. Based on the investigated circumstances, the manner of death was evaluated as a suicide.
{"title":"Suicides by ingestion of pure caffeine powder. New challenge for public health?","authors":"Jozef Sidlo, Jan Sikuta, Henrieta Sidlova, Lubos Niznansky","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Intentional or unintentional caffeine abuse due to excessive intake of energy beverages is frequent. Fatalities due to caffeine intoxication are presented rarely. Over the last years, cases of caffeine ingestion for purposes of committing suicide have been reported in scientific literature.</p><p><strong>Design: </strong>The aim of this case study is to report a fatal case of a 26-year-old man who intentionally ingested pure caffeine powder.</p><p><strong>Methods: </strong>Standard autopsy, microscopic examination and toxicological examination using screening method, TLC, GC, and GC/MS were performed.</p><p><strong>Results and conclusions: </strong>The presence of caffeine only at the concentration of 362 ug/mL in blood and 187 ug/mL in urine was revealed. The cause of death was cardiac arrest most likely due to ventricular dysrhythmia. The concentration of caffeine determined in the femoral blood of the decedent was three times higher than the lethal concentrations reported in other published case studies. Based on the investigated circumstances, the manner of death was evaluated as a suicide.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"40 Suppl1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2019-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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