Pub Date : 2019-06-01DOI: 10.21608/bnni.2019.55475
Dina Is, Afaf Hs, Nefisa Hb, Mohamed Mn
The research was carried out to study the effect of some personal, behavioral, and environmental factors on vitamin D level amonguniversity female undergraduates in Egypt.A convenient sample consisted of125 first grade Egyptianuniversity female youth was selected. Written consentswerean initial basic step. They filled aknowledge, attitudes, and practice (KAP) pre-structured questionnaire and were subjected to dietary assessmentusing 24 hours recall, frequencypattern, and milk consumption sheets. Laboratory evaluation of vitamin D and related indicators were measured. Food intake was analyzed and compared to the recommended dietary allowances using the food composition table of the National Nutrition Institute and based on WHO/FAO recommendations. Resultsrevealed that majority of respondents (96.0%) were veiled and 88.0 % were exposed to sun at noon time. Face and hands were the exposed parts in 96.0% of responses and 56.0 % mentioned that sun- exposure took more than an hour. Exposure to pesticides was mentioned in 16.0% of responses. Nearly two thirds were exposed to sun while windows were closed. Only 22.0% heard about vitamin D and two thirds considered milk among un-favored food items. This study concluded that to track progress toward getting rid of a health problem, we have to raise the level of awareness of youth and young adults about this problem.This study emphasized the need for further vitamin D assessment and interventions targeted at all people. There is an urgent need for public education about the vital role of vitamin D to improve vitamin D- related practice and to minimize the complications of its deficiency.
{"title":"Knowledge, Attitudes, Behavior and their impact on Vitamin D Status among Undergraduate University Female Students","authors":"Dina Is, Afaf Hs, Nefisa Hb, Mohamed Mn","doi":"10.21608/bnni.2019.55475","DOIUrl":"https://doi.org/10.21608/bnni.2019.55475","url":null,"abstract":"The research was carried out to study the effect of some personal, behavioral, and environmental factors on vitamin D level amonguniversity female undergraduates in Egypt.A convenient sample consisted of125 first grade Egyptianuniversity female youth was selected. Written consentswerean initial basic step. They filled aknowledge, attitudes, and practice (KAP) pre-structured questionnaire and were subjected to dietary assessmentusing 24 hours recall, frequencypattern, and milk consumption sheets. Laboratory evaluation of vitamin D and related indicators were measured. Food intake was analyzed and compared to the recommended dietary allowances using the food composition table of the National Nutrition Institute and based on WHO/FAO recommendations. Resultsrevealed that majority of respondents (96.0%) were veiled and 88.0 % were exposed to sun at noon time. Face and hands were the exposed parts in 96.0% of responses and 56.0 % mentioned that sun- exposure took more than an hour. Exposure to pesticides was mentioned in 16.0% of responses. Nearly two thirds were exposed to sun while windows were closed. Only 22.0% heard about vitamin D and two thirds considered milk among un-favored food items. This study concluded that to track progress toward getting rid of a health problem, we have to raise the level of awareness of youth and young adults about this problem.This study emphasized the need for further vitamin D assessment and interventions targeted at all people. There is an urgent need for public education about the vital role of vitamin D to improve vitamin D- related practice and to minimize the complications of its deficiency.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81188518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.21608/bnni.2019.55294
Soheir M. El-deab
he study aimed to identify the role of kindergarten teachers during the mealtime in providing nutritional knowledge of the kindergarten child. To achieve this, a descriptive method was used. The questionnaire was used as data collection tool. The sample consisted of (60) Kindergarten Teachers. In the analysis of the data, the study showed that the tool obtained an average of (2. 95 from 4. 00) and at the field level Axis concept of nutritional knowledge (2. 88). Followed by the difficulty of kindergarten teachers during the mealtime, teachers were at an average of (2.49). Both of which are rated (High), while very high on (kindergarten teacher practices during the mealtime at an average of (3.46).The teachers also showed that the meals attended by the children are healthy and that there is awareness among the families about the type of food provided to the children. In the light of the results of this study, a number of recommendation and suggestions are made to introduce the food culture of the child as judges in the rehabilitation and training of nannies and teachers.
{"title":"Role of Kindergarten Teachers During the mealtime in achieving the nutritional knowledge of Kindergarten Children in Afif city, Kingdom of Saudi Arabia","authors":"Soheir M. El-deab","doi":"10.21608/bnni.2019.55294","DOIUrl":"https://doi.org/10.21608/bnni.2019.55294","url":null,"abstract":"he study aimed to identify the role of kindergarten teachers during the mealtime in providing nutritional knowledge of the kindergarten child. To achieve this, a descriptive method was used. The questionnaire was used as data collection tool. The sample consisted of (60) Kindergarten Teachers. In the analysis of the data, the study showed that the tool obtained an average of (2. 95 from 4. 00) and at the field level Axis concept of nutritional knowledge (2. 88). Followed by the difficulty of kindergarten teachers during the mealtime, teachers were at an average of (2.49). Both of which are rated (High), while very high on (kindergarten teacher practices during the mealtime at an average of (3.46).The teachers also showed that the meals attended by the children are healthy and that there is awareness among the families about the type of food provided to the children. In the light of the results of this study, a number of recommendation and suggestions are made to introduce the food culture of the child as judges in the rehabilitation and training of nannies and teachers.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83122986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01DOI: 10.21608/BNNI.2018.31430
Mohamed Mohammady, M. Kassem
ABSTRACTFifty five sample (40 sample from juices and 15 swab)collected from juices company in Cairo that wereexamined during the application of Good ManufacturingPractices (GMP) of mango juices and mango pulp includedswabs of the food handlers, equipment and walls. The aerobictotal count was 3x103 cfu from wall, 5x103 cfu from food handlersand was 5x104 from equipment coliform count was 3x103 fromwall, 2x103 cfu from food handler and 5x105 from equipmentwhile mold and yeast was 5 x 105 from walls, 3 x 104 from foodhandlers and 5x104 from equipment. After application of thosepractices, the samples from mango juices and mango pulpbecame safe and free from pathogenic microorganisms. Also,theresults show the final products were safe.
{"title":"Good Manufacturing Practices (GMP) during the Production of Mango Juice and Mango Pulp","authors":"Mohamed Mohammady, M. Kassem","doi":"10.21608/BNNI.2018.31430","DOIUrl":"https://doi.org/10.21608/BNNI.2018.31430","url":null,"abstract":"ABSTRACTFifty five sample (40 sample from juices and 15 swab)collected from juices company in Cairo that wereexamined during the application of Good ManufacturingPractices (GMP) of mango juices and mango pulp includedswabs of the food handlers, equipment and walls. The aerobictotal count was 3x103 cfu from wall, 5x103 cfu from food handlersand was 5x104 from equipment coliform count was 3x103 fromwall, 2x103 cfu from food handler and 5x105 from equipmentwhile mold and yeast was 5 x 105 from walls, 3 x 104 from foodhandlers and 5x104 from equipment. After application of thosepractices, the samples from mango juices and mango pulpbecame safe and free from pathogenic microorganisms. Also,theresults show the final products were safe.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72900532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01DOI: 10.21608/bnni.2018.31434
Heba A, Baseem Z, Abdelhamid E
{"title":"Relation between nutritional status and inherited disorders of hemoglobin (thalassemia) in Egyptian children","authors":"Heba A, Baseem Z, Abdelhamid E","doi":"10.21608/bnni.2018.31434","DOIUrl":"https://doi.org/10.21608/bnni.2018.31434","url":null,"abstract":"","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85441458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01DOI: 10.21608/BNNI.2018.31436
M. El-sayed, M. Amr, Tarek M. Afifi, Karee Asmaa
ABSTRACTThe lack of health and food awareness of mothers is the uniting factorsaffecting the nutritional status of autism children.Therefore,theresearch sample was divided into two groups; which included the firstset before implementing the program of (75) mothers, a while the numbers ofsupervisors (68) were chosen from three centers in the cities of Cairo andMansoura.The second group composed of a total number of (29) mothers and(29) supervisors. The first model: a questionnaire for the mother,the secondmodel: aquestionnaire for the supervisors,the third model: A specialquestionnaire to develop the skill of the manual study sample in the basics ofnutrition and meal planning.The results showed after correcting their answersthat the degree ranged between 12 to 21 degree, an average of 17.17±2.28,which means the standard level, was average, which confirmed that moreadvanced workshops are needed to raise the level of theknowledge. Afterwardsapplying the workshop scheduled for extension program for the improvementof knowledge in planning meals that were measured through the knowledgetest. The test to measure the level of knowledge is evident from these resultsafter correcting their answers and their grades ranged between 13 to 25degrees, an average of 18.04±3.39 degree, which means, the standard levelwas average.The study concluded the importance of further educationprograms and the dissemination of food program at all extension centers in theArab Republic of Egypt.
{"title":"The Effectiveness of Nutritional Edification Programs for Mothers and Supervisors of Autistic Children","authors":"M. El-sayed, M. Amr, Tarek M. Afifi, Karee Asmaa","doi":"10.21608/BNNI.2018.31436","DOIUrl":"https://doi.org/10.21608/BNNI.2018.31436","url":null,"abstract":"ABSTRACTThe lack of health and food awareness of mothers is the uniting factorsaffecting the nutritional status of autism children.Therefore,theresearch sample was divided into two groups; which included the firstset before implementing the program of (75) mothers, a while the numbers ofsupervisors (68) were chosen from three centers in the cities of Cairo andMansoura.The second group composed of a total number of (29) mothers and(29) supervisors. The first model: a questionnaire for the mother,the secondmodel: aquestionnaire for the supervisors,the third model: A specialquestionnaire to develop the skill of the manual study sample in the basics ofnutrition and meal planning.The results showed after correcting their answersthat the degree ranged between 12 to 21 degree, an average of 17.17±2.28,which means the standard level, was average, which confirmed that moreadvanced workshops are needed to raise the level of theknowledge. Afterwardsapplying the workshop scheduled for extension program for the improvementof knowledge in planning meals that were measured through the knowledgetest. The test to measure the level of knowledge is evident from these resultsafter correcting their answers and their grades ranged between 13 to 25degrees, an average of 18.04±3.39 degree, which means, the standard levelwas average.The study concluded the importance of further educationprograms and the dissemination of food program at all extension centers in theArab Republic of Egypt.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75984139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01DOI: 10.21608/bnni.2018.31437
E. M, E. M, E. H.
ish bone and egg shell are considered as waste products. Thus, reprocessing and eventual utilization of waste products have beneficial uses rather than their discharge to the environment which cause detrimental environmental effects. Fish bone and egg shell could be utilized as dietary calcium source and added to the produce calcium-rich bakery product (Baton sale'). Baton sale' was prepared from wheat flour supplemented by fish Tilapia bone and chicken egg shell in two concentrations 5% and 7%. Chemical composition of (wheat flour, egg shell and fish bone) and the fortified baton sale' products were measured. The nutritional value and sensorial properties were evaluated. The results indicated that addition of fish bone or egg shell powder gave a pronounced increase in gross chemical composition of baton Sale' as compared to control. Also most of the mineral increased than control especially Ca. All sensory evaluations were acceptable for all fortified baton Sale' as bakery products. The percentage calculated of the examine minerals were on percentage of RDA. Egg shell powder and fish bone are an appropriate and cheap source of calcium for human nutrition and easily prepared at home.
{"title":"Utilization of Fish Bone and Egg Shell to Nutritional support of Baton Sale","authors":"E. M, E. M, E. H.","doi":"10.21608/bnni.2018.31437","DOIUrl":"https://doi.org/10.21608/bnni.2018.31437","url":null,"abstract":"ish bone and egg shell are considered as waste products. Thus, reprocessing and eventual utilization of waste products have beneficial uses rather than their discharge to the environment which cause detrimental environmental effects. Fish bone and egg shell could be utilized as dietary calcium source and added to the produce calcium-rich bakery product (Baton sale'). Baton sale' was prepared from wheat flour supplemented by fish Tilapia bone and chicken egg shell in two concentrations 5% and 7%. Chemical composition of (wheat flour, egg shell and fish bone) and the fortified baton sale' products were measured. The nutritional value and sensorial properties were evaluated. The results indicated that addition of fish bone or egg shell powder gave a pronounced increase in gross chemical composition of baton Sale' as compared to control. Also most of the mineral increased than control especially Ca. All sensory evaluations were acceptable for all fortified baton Sale' as bakery products. The percentage calculated of the examine minerals were on percentage of RDA. Egg shell powder and fish bone are an appropriate and cheap source of calcium for human nutrition and easily prepared at home.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79296839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01DOI: 10.21608/BNNI.2018.31432
H. Sheha, H. E. Gezery
ABSTRACTPrickly pear peels contain essential compounds such as taurine, amino acids, readily absorbable carbohydrates, minerals, vitamin C, flavonoids, tocopherols, and carotenoids. These compounds and derivatives were shown to be endowed with biologically relevant activities including anti-inflammatory, antioxidant, hypoglycemic and antimicrobial properties. The present study was designed to investigate some parameters of the chemical composition of prickly pear peels and the effect of their nutritional status on liver and renal injury in rats. Thirty adult male albino rats Sprague–Dawley strain were classified into 2 main groups fed several diets for 28 days as follows: The first negative control group (6 rats / normal group) fed on standard diet. The second group (24rat) injected by carbon tetrachloride (CCl4); 6 rats presented as a positive control group fed on basal diet. 18 rats were as subgroups 1, 2 and 3 fed on basal diet with 5, 10 and 15% prickly pear peels respectively. At the end of the experimental period (4 week) biological parameters; some biochemical parameters and the histology for liver and renal were evaluated. The results showed a high value of moisture, carbohydrates, protein in prickly pear peels. The positive control group had a significantly lower value of the body weight gain. Liver enzymes and renal parameter of positive control group were higher significantly than negative control group and treated groups. Prickly pear peel ameliorates the effect CCl4 on liver and kidney in rats.
{"title":"Evaluation of feeding prickly pear peels to ameliorate the effect of Carbon tetrachloride in rats","authors":"H. Sheha, H. E. Gezery","doi":"10.21608/BNNI.2018.31432","DOIUrl":"https://doi.org/10.21608/BNNI.2018.31432","url":null,"abstract":"ABSTRACTPrickly pear peels contain essential compounds such as taurine, amino acids, readily absorbable carbohydrates, minerals, vitamin C, flavonoids, tocopherols, and carotenoids. These compounds and derivatives were shown to be endowed with biologically relevant activities including anti-inflammatory, antioxidant, hypoglycemic and antimicrobial properties. The present study was designed to investigate some parameters of the chemical composition of prickly pear peels and the effect of their nutritional status on liver and renal injury in rats. Thirty adult male albino rats Sprague–Dawley strain were classified into 2 main groups fed several diets for 28 days as follows: The first negative control group (6 rats / normal group) fed on standard diet. The second group (24rat) injected by carbon tetrachloride (CCl4); 6 rats presented as a positive control group fed on basal diet. 18 rats were as subgroups 1, 2 and 3 fed on basal diet with 5, 10 and 15% prickly pear peels respectively. At the end of the experimental period (4 week) biological parameters; some biochemical parameters and the histology for liver and renal were evaluated. The results showed a high value of moisture, carbohydrates, protein in prickly pear peels. The positive control group had a significantly lower value of the body weight gain. Liver enzymes and renal parameter of positive control group were higher significantly than negative control group and treated groups. Prickly pear peel ameliorates the effect CCl4 on liver and kidney in rats.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90691080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.21608/BNNI.2018.14161
E. H.E
Nowadays foods are not purposed to only accept hunger and to give vital nutrients for humans, but also to protect and treated nutrition-related diseases and ameliorate physical and mental status of the consumers. In this respect, probiotic play a prominent role. Thence this study aimed to estimate the chemical constituents of kefir and kefir grain and identify the potential protective effect of probiotic (yoghurt/ kefir milk / kefir grain) to diminish the risk of lead (Pb) intoxication on male rats. Biological study was administered on forty two male rats which allotted into 6 groups involved negative control group (7 rats) , normal group consumed kefir milk and four groups which treated 50 mg of lead/kg body weight per day as testicular toxicant and classified into positive control group (+ve) , subgroups : yoghurt, kefir milk and kefir grain subgroups. The results revealed that all experimental treatments enhanced liver and kidney functions , antioxidant parameters and testosterone hormone levels, luteinizing hormone (LH) and follicle stimulating hormone level (FSH) the most prominent positive effects were perceived in the group that consumed kefir milk and kefir grain. These acquired results are assured by the histopathological examination. In the present study, the protective effect of kefir milk and kefir grain against lead toxicity in rats was become well. Therefore, this study recommends that consume kefir and supplemented the products with kefir grains to prevent the damage caused by lead contamination.
{"title":"The protective effect of kefir as a probiotic on reproductive potential of male rats","authors":"E. H.E","doi":"10.21608/BNNI.2018.14161","DOIUrl":"https://doi.org/10.21608/BNNI.2018.14161","url":null,"abstract":"Nowadays foods are not purposed to only accept hunger and to give vital nutrients for humans, but also to protect and treated nutrition-related diseases and ameliorate physical and mental status of the consumers. In this respect, probiotic play a prominent role. Thence this study aimed to estimate the chemical constituents of kefir and kefir grain and identify the potential protective effect of probiotic (yoghurt/ kefir milk / kefir grain) to diminish the risk of lead (Pb) intoxication on male rats. Biological study was administered on forty two male rats which allotted into 6 groups involved negative control group (7 rats) , normal group consumed kefir milk and four groups which treated 50 mg of lead/kg body weight per day as testicular toxicant and classified into positive control group (+ve) , subgroups : yoghurt, kefir milk and kefir grain subgroups. The results revealed that all experimental treatments enhanced liver and kidney functions , antioxidant parameters and testosterone hormone levels, luteinizing hormone (LH) and follicle stimulating hormone level (FSH) the most prominent positive effects were perceived in the group that consumed kefir milk and kefir grain. These acquired results are assured by the histopathological examination. In the present study, the protective effect of kefir milk and kefir grain against lead toxicity in rats was become well. Therefore, this study recommends that consume kefir and supplemented the products with kefir grains to prevent the damage caused by lead contamination.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85948005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.21608/BNNI.2018.14155
S. Hamdy, Saad M. El-Gendy, S. Atrees
Hepatocellular carcinoma (HCC) is a common malignant affecting approximately-one million of people around the world every year. This study aimed to early recognition of the carcinogenic effect of N-nitrosodiethlyamine (NDEA) on hepatocytes and expression of Fas-L and Caspase-3. The study was done using tissue homogenate of 60 male albino rats divided into 2 groups: group 1,control group (30 rats) and Group 2, -N-nitrosodiethylamine (NDEA) treated group (NDEA, in a single dose 200 mg/Kg wt and; Carbon tetrachloride (CCL4), twice per week 3 ml/Kg wt) (30 rats). 10 rats from each control and treated group were sacrificed at the 1st, 2n , and 3rd months of the treatment for evaluation (1) of glutathione s transferase(GST), glutathione peroxidase (GPx), glutathione reductase (GRase), glutathione reduced form (GSH), superoxide dismutase (SOD) levels, (2) studying expression of Fas-L and Caspase-3 and (3) for histopathological examination. The results revealed that the treated group antioxidant enzymes levels (Glutathione family and SOD) showed a significant decrease with gradual rates through the three months of the treated compared to the control group, whereas the GRase level was significantly increased compared to the control group. Caspase-3 and Fas-L in liver tissue homogenate in the treated group was significantly decreased in comparison with the control group. The histopathological results showed pronounced changes with evident fatty degeneration (steatosis), marked microvascular steatosis with malignant hepatocytes amounting grade 1. Finally, study can conclude that investigation of liver tissue markers induced by the chemical carcinogen NDEA at different stages of the development of cancer could help in getting more information about the development of HCC and more investigated studies on Caspase-3 and Fas-L, could be a promising way for the treatment of HCC.
{"title":"CASPASE-3 and FAS-L expression and their roles as signal transduction in hepatocellular carcinoma","authors":"S. Hamdy, Saad M. El-Gendy, S. Atrees","doi":"10.21608/BNNI.2018.14155","DOIUrl":"https://doi.org/10.21608/BNNI.2018.14155","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a common malignant affecting approximately-one million of people around the world every year. This study aimed to early recognition of the carcinogenic effect of N-nitrosodiethlyamine (NDEA) on hepatocytes and expression of Fas-L and Caspase-3. The study was done using tissue homogenate of 60 male albino rats divided into 2 groups: group 1,control group (30 rats) and Group 2, -N-nitrosodiethylamine (NDEA) treated group (NDEA, in a single dose 200 mg/Kg wt and; Carbon tetrachloride (CCL4), twice per week 3 ml/Kg wt) (30 rats). 10 rats from each control and treated group were sacrificed at the 1st, 2n , and 3rd months of the treatment for evaluation (1) of glutathione s transferase(GST), glutathione peroxidase (GPx), glutathione reductase (GRase), glutathione reduced form (GSH), superoxide dismutase (SOD) levels, (2) studying expression of Fas-L and Caspase-3 and (3) for histopathological examination. The results revealed that the treated group antioxidant enzymes levels (Glutathione family and SOD) showed a significant decrease with gradual rates through the three months of the treated compared to the control group, whereas the GRase level was significantly increased compared to the control group. Caspase-3 and Fas-L in liver tissue homogenate in the treated group was significantly decreased in comparison with the control group. The histopathological results showed pronounced changes with evident fatty degeneration (steatosis), marked microvascular steatosis with malignant hepatocytes amounting grade 1. Finally, study can conclude that investigation of liver tissue markers induced by the chemical carcinogen NDEA at different stages of the development of cancer could help in getting more information about the development of HCC and more investigated studies on Caspase-3 and Fas-L, could be a promising way for the treatment of HCC.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87232837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.21608/BNNI.2018.14160
Tarek M. Afifi, A. El-Ashmawy, Nadia El-Fakharany
Medical nutrition therapy was as a potential treatment for acne because it play very important role in control on condition. The objective of this study was to identify the role of diet on pathogenesis and enhancement of acne cases. The study included30 patients with mean age (12-24 y) with two degrees of acne (mild and sever) .they were divided into three groups every group included 10 patients (5 males and 5 females) The first group treated by drug, second group treated by experimental diet and third group treated by both of drug and experimental diet .The study began in the period from April 2015 to December 2016. Our results showed that correlation coefficient food intake with biochemical analysis in the studied groups .There relationship between deficiency vitamins with deficiency GSH and increased androgens hormones .also, there was correlated between deficiency zinc, calcium, magnesium and vitamins with increased cholesterol, triglycerides, and androgen hormones .also, there was high significant correlation positive between deficiency ca, mg zinc intake with decrease GST. Conclusion, macronutrients (carbohydrates, proteins, fiber and fats) and micronutrients (vitamins and minerals essential from a nutritional point of view) preserve the skin from worsening acne and improve its appearance.
{"title":"Evaluation of the therapeutic diet for enhancement of acne status","authors":"Tarek M. Afifi, A. El-Ashmawy, Nadia El-Fakharany","doi":"10.21608/BNNI.2018.14160","DOIUrl":"https://doi.org/10.21608/BNNI.2018.14160","url":null,"abstract":"Medical nutrition therapy was as a potential treatment for acne because it play very important role in control on condition. The objective of this study was to identify the role of diet on pathogenesis and enhancement of acne cases. The study included30 patients with mean age (12-24 y) with two degrees of acne (mild and sever) .they were divided into three groups every group included 10 patients (5 males and 5 females) The first group treated by drug, second group treated by experimental diet and third group treated by both of drug and experimental diet .The study began in the period from April 2015 to December 2016. Our results showed that correlation coefficient food intake with biochemical analysis in the studied groups .There relationship between deficiency vitamins with deficiency GSH and increased androgens hormones .also, there was correlated between deficiency zinc, calcium, magnesium and vitamins with increased cholesterol, triglycerides, and androgen hormones .also, there was high significant correlation positive between deficiency ca, mg zinc intake with decrease GST. Conclusion, macronutrients (carbohydrates, proteins, fiber and fats) and micronutrients (vitamins and minerals essential from a nutritional point of view) preserve the skin from worsening acne and improve its appearance.","PeriodicalId":9493,"journal":{"name":"Bulletin of the National Nutrition Institute of the Arab Republic of Egypt","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88418609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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