Pub Date : 2024-01-28DOI: 10.15829/1728-8800-2023-3829
Zh. L. Varakina, N. Y. Shkerskaya, V. R. Losev, E. V. Zimina, L. I. Menshikova
Aim. To study the opinion of senior medical students about their readiness for self-guided practice in primary health care organizations.Material and methods. In 2023, a continuous cross- sectional social study was conducted among 5th and 6th year students of the Northern State Medical University (Arkhangelsk), of which 137 were from pediatric faculty (5th year — 70, 6th year — 65), 266 — general medicine faculty (5th year — 140, 6th year — 126).Results. An insufficient level of readiness of medical graduates for self-guided practice in primary health care facilities was revealed. Only 19,0%, after passing the primary accreditation, aim to immediately work as a local pediatrician and a local general practitioner, while 44,2% are not ready to begin independent practical activity. The main work direction of a local physician is considered to be prevention by 67,2% and 28,6% of senior pediatric and general medicine students, respectively. More than 75% of graduates are ready to work independently in a medical information system, but 15,1% of respondents are not sure that they will be able to independently make an electronic sick note, while 41% — a referral for disability examination, and about a third of graduates — fill out a statistical electronic form.Conclusion. The study results confirm the need to strengthen the practice in the training of medical students and introduce a mentoring system in primary health care facilities.
{"title":"Readiness of medical graduates to self-guided work in primary health care organizations","authors":"Zh. L. Varakina, N. Y. Shkerskaya, V. R. Losev, E. V. Zimina, L. I. Menshikova","doi":"10.15829/1728-8800-2023-3829","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3829","url":null,"abstract":"Aim. To study the opinion of senior medical students about their readiness for self-guided practice in primary health care organizations.Material and methods. In 2023, a continuous cross- sectional social study was conducted among 5th and 6th year students of the Northern State Medical University (Arkhangelsk), of which 137 were from pediatric faculty (5th year — 70, 6th year — 65), 266 — general medicine faculty (5th year — 140, 6th year — 126).Results. An insufficient level of readiness of medical graduates for self-guided practice in primary health care facilities was revealed. Only 19,0%, after passing the primary accreditation, aim to immediately work as a local pediatrician and a local general practitioner, while 44,2% are not ready to begin independent practical activity. The main work direction of a local physician is considered to be prevention by 67,2% and 28,6% of senior pediatric and general medicine students, respectively. More than 75% of graduates are ready to work independently in a medical information system, but 15,1% of respondents are not sure that they will be able to independently make an electronic sick note, while 41% — a referral for disability examination, and about a third of graduates — fill out a statistical electronic form.Conclusion. The study results confirm the need to strengthen the practice in the training of medical students and introduce a mentoring system in primary health care facilities.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"375 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-28DOI: 10.15829/1728-8800-2023-3835
D. V. Voshev, I. M. Son, N. A. Vosheva, S. Orlov, K. Mezhidov, R. Shepel, O. Drapkina
Aim. To analyze digital technologies in the primary health care system, as well as studying the impact of digital health literacy on patient satisfaction with the services provided.Material and methods. A study assessing patients' opinions on the digitalization of primary care in Russia was conducted from June to September 2023 among 1004 participants from 42 regions. A questionnaire with 33 questions was used, of which the 8 most relevant ones were selected for the article, aimed at assessing the satisfaction and personal experience of patients in using digital technologies. Data was collected through Yandex Forms. Data analysis included synthesis of results, classification and content analysis of literature.Results. The study examined the impact of digitalization on primary care patient satisfaction. Analysis of digital technologies in the primary health care system made it possible to establish that the target audience has a positive attitude towards the introduction of innovations. The patients also aimed at using them and are ready to seek new digital medical services. At the same time, it is important for patients to increase the effectiveness of personal interaction with the physicians. In order to improve digital innovation, development of practical guidelines for the updating and further implementation of digital tools is needed.Conclusion. The study confirmed that digital health literacy plays an important role in improving primary care patient satisfaction. Based on the data obtained, it is necessary to develop and implement educational programs for patients and medical professionals aimed at increasing the level of digital literacy and optimizing the use of digital tools in me dicine.
{"title":"Digital health literacy in primary care: a key driver of patient satisfaction in the era of digital transformation in healthcare","authors":"D. V. Voshev, I. M. Son, N. A. Vosheva, S. Orlov, K. Mezhidov, R. Shepel, O. Drapkina","doi":"10.15829/1728-8800-2023-3835","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3835","url":null,"abstract":"Aim. To analyze digital technologies in the primary health care system, as well as studying the impact of digital health literacy on patient satisfaction with the services provided.Material and methods. A study assessing patients' opinions on the digitalization of primary care in Russia was conducted from June to September 2023 among 1004 participants from 42 regions. A questionnaire with 33 questions was used, of which the 8 most relevant ones were selected for the article, aimed at assessing the satisfaction and personal experience of patients in using digital technologies. Data was collected through Yandex Forms. Data analysis included synthesis of results, classification and content analysis of literature.Results. The study examined the impact of digitalization on primary care patient satisfaction. Analysis of digital technologies in the primary health care system made it possible to establish that the target audience has a positive attitude towards the introduction of innovations. The patients also aimed at using them and are ready to seek new digital medical services. At the same time, it is important for patients to increase the effectiveness of personal interaction with the physicians. In order to improve digital innovation, development of practical guidelines for the updating and further implementation of digital tools is needed.Conclusion. The study confirmed that digital health literacy plays an important role in improving primary care patient satisfaction. Based on the data obtained, it is necessary to develop and implement educational programs for patients and medical professionals aimed at increasing the level of digital literacy and optimizing the use of digital tools in me dicine.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"371 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-23DOI: 10.15829/1728-8800-2024-3920
Yy. V. Lukina, N. Kutishenko, S. Martsevich, O. Drapkina
The second publication is presented, devoted to the classification of the main parameters of quality and adherence to pharmacotherapy. Despite the fact that patients play a central role in the problem of medical adherence, the role of attending physicians is extremely significant both in prescribing/non-prescribing proven effective and safe therapy, and in influencing patient medical adherence. This led to the identification of a special commitment type — the physician adherence to the basic principles of rational treatment. Collection, analysis and systematization of information, as well as the related development of a classification of physician adherence/non-adherence were the aim of this review and analytical work. We searched data using keywords among Russian and English-language sources. When compiling the classification, categories of adherence/non-adherence were identified in accordance with the implementation by physicians of the main provisions of clinical guidelines for long-term therapy for patients with non-communicable diseases (NCDs), as well as following official drug labels reflecting data on clinical pharmacology, the main side effects, drug-drug interactions. The classification of physician adherence/non-adherence to implementing the principles of rational treatment of patients with NCDs can be used in the development of electronic medical decision support systems for providing therapy with proven effectiveness and safety in specific clinical situations. In addition, on the basis of the developed classification, checklists for monitoring by healthcare specialists of the implementation of the rational treatment of patients with chronic NCDs should be created.
{"title":"Problematic issues and development of classifications of the main parameters of quality and adherence to pharmacotherapy. Part II: physician adherence to clinical guidelines and official drug labels","authors":"Yy. V. Lukina, N. Kutishenko, S. Martsevich, O. Drapkina","doi":"10.15829/1728-8800-2024-3920","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3920","url":null,"abstract":"The second publication is presented, devoted to the classification of the main parameters of quality and adherence to pharmacotherapy. Despite the fact that patients play a central role in the problem of medical adherence, the role of attending physicians is extremely significant both in prescribing/non-prescribing proven effective and safe therapy, and in influencing patient medical adherence. This led to the identification of a special commitment type — the physician adherence to the basic principles of rational treatment. Collection, analysis and systematization of information, as well as the related development of a classification of physician adherence/non-adherence were the aim of this review and analytical work. We searched data using keywords among Russian and English-language sources. When compiling the classification, categories of adherence/non-adherence were identified in accordance with the implementation by physicians of the main provisions of clinical guidelines for long-term therapy for patients with non-communicable diseases (NCDs), as well as following official drug labels reflecting data on clinical pharmacology, the main side effects, drug-drug interactions. The classification of physician adherence/non-adherence to implementing the principles of rational treatment of patients with NCDs can be used in the development of electronic medical decision support systems for providing therapy with proven effectiveness and safety in specific clinical situations. In addition, on the basis of the developed classification, checklists for monitoring by healthcare specialists of the implementation of the rational treatment of patients with chronic NCDs should be created.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"71 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140498202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.15829/1728-8800-2023-3751
A. Yafarova, E. D. Dementyeva, O. A. Zlobovskaya, A. R. Kiselev, A. Sheptulina, G. A. Ashniev, L. M. Zhamalov, V. Makarov, S. Yudin, O. Drapkina
Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.
{"title":"Gut microbiota at different stages of cardiovascular disease continuum","authors":"A. Yafarova, E. D. Dementyeva, O. A. Zlobovskaya, A. R. Kiselev, A. Sheptulina, G. A. Ashniev, L. M. Zhamalov, V. Makarov, S. Yudin, O. Drapkina","doi":"10.15829/1728-8800-2023-3751","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3751","url":null,"abstract":"Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"126 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140515610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.15829/1728-8800-2023-3805
A. V. Morozkina, A. Vorobev, M. Y. Donnikov, L. V. Kovalenko, M. L. Safronova, A. K. Gapurova, K. Y. Nikolaev
Aim. Creation of a sample collection of whole blood, leukocyte suspension, genomic deoxyribonucleic acid from patients with myocardial infarction for fundamental and applied research in medicine.Materials and methods. The collection, transportation and processing of biomaterial samples in the biobank of the Medical Institute of Surgut State University were carried out according to standard methods using recommendations, standard operating procedures and national guidelines for biobanking.Results. As of September 1, 2023, the collection has collected 744 aliquots of whole blood and leukocyte suspension and isolated 108 samples of genomic deoxyribonucleic acid from 108 donors after myocardial infarction. Aliquots of samples from the biobank collection are actively used for a number of molecular genetic studies (genotyping, massively parallel sequencing).Conclusion. This biosample collection on the basis of Surgut State University provides current and future research projects in cardiology with high-quality biomaterial.
{"title":"Creation of a biosample collection from patients after myocardial infarction in the Khanty Mansi Autonomous Okrug — Yugra","authors":"A. V. Morozkina, A. Vorobev, M. Y. Donnikov, L. V. Kovalenko, M. L. Safronova, A. K. Gapurova, K. Y. Nikolaev","doi":"10.15829/1728-8800-2023-3805","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3805","url":null,"abstract":"Aim. Creation of a sample collection of whole blood, leukocyte suspension, genomic deoxyribonucleic acid from patients with myocardial infarction for fundamental and applied research in medicine.Materials and methods. The collection, transportation and processing of biomaterial samples in the biobank of the Medical Institute of Surgut State University were carried out according to standard methods using recommendations, standard operating procedures and national guidelines for biobanking.Results. As of September 1, 2023, the collection has collected 744 aliquots of whole blood and leukocyte suspension and isolated 108 samples of genomic deoxyribonucleic acid from 108 donors after myocardial infarction. Aliquots of samples from the biobank collection are actively used for a number of molecular genetic studies (genotyping, massively parallel sequencing).Conclusion. This biosample collection on the basis of Surgut State University provides current and future research projects in cardiology with high-quality biomaterial.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"1062 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.15829/1728-8800-2023-3864
A. N. Meshkov, M. S. Pokrovskaya, A. Glotov, A. Ershova, Yu. V. Rodionova, O. Drapkina
.
.
{"title":"From idea to implementation: the development of biobanking in Russia. The Cardiovascular Therapy and Prevention journal’s top contributing institutions: National Association of Biobanks and Biobanking Specialists (NASBIO)","authors":"A. N. Meshkov, M. S. Pokrovskaya, A. Glotov, A. Ershova, Yu. V. Rodionova, O. Drapkina","doi":"10.15829/1728-8800-2023-3864","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3864","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"30 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138981967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.15829/1728-8800-2023-3711
Y. V. Russkikh, N. Sushentseva, O. Popov, S. Apalko, A. Anisenkova, S. V. Mosenko, A. Sarana, S. G. Shcherbak
Aim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical and laboratory history. Studying the relationship between the severity of COVID-19 symptoms and the concentration of primary metabolites, primarily amino acids.Material and methods. The retrospective study included serum samples from a total of 935 people (445 men and 490 women) with COVID-19 from the collection of the biobank of the City Hospital № 40. A metabolomic profile was studied in all samples using chromatography-mass spectrometry. The R language was used for statistical data processing.Results. Based on the analysis, a difference in the metabolic profile of patients with COVID-19 was identified depending on the disease severity — for 52 of the 84 detected compounds, differences were observed with a significance of p<0,01. Significant differences in concentration were recorded for organic acids, amino acids and their derivatives.Conclusion. Using samples from the biobank collection, a metabolomic study of the biomaterial of patients hospitalized with a diagnosis of COVID-19 was carried out. According to the results obtained, kynurenine, phenylalanine and acetylcarnitine are associated with COVID-19 severity. Differences in the metabolomic profile were identified in patients with cytokine storm at the time of blood collection. Potential biomarkers for cytokine storm were identified.
{"title":"Study of the metabolome features of patients with COVID-19","authors":"Y. V. Russkikh, N. Sushentseva, O. Popov, S. Apalko, A. Anisenkova, S. V. Mosenko, A. Sarana, S. G. Shcherbak","doi":"10.15829/1728-8800-2023-3711","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3711","url":null,"abstract":"Aim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical and laboratory history. Studying the relationship between the severity of COVID-19 symptoms and the concentration of primary metabolites, primarily amino acids.Material and methods. The retrospective study included serum samples from a total of 935 people (445 men and 490 women) with COVID-19 from the collection of the biobank of the City Hospital № 40. A metabolomic profile was studied in all samples using chromatography-mass spectrometry. The R language was used for statistical data processing.Results. Based on the analysis, a difference in the metabolic profile of patients with COVID-19 was identified depending on the disease severity — for 52 of the 84 detected compounds, differences were observed with a significance of p<0,01. Significant differences in concentration were recorded for organic acids, amino acids and their derivatives.Conclusion. Using samples from the biobank collection, a metabolomic study of the biomaterial of patients hospitalized with a diagnosis of COVID-19 was carried out. According to the results obtained, kynurenine, phenylalanine and acetylcarnitine are associated with COVID-19 severity. Differences in the metabolomic profile were identified in patients with cytokine storm at the time of blood collection. Potential biomarkers for cytokine storm were identified.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.15829/1728-8800-20233746
A. Kiseleva, A. G. Soplenkova, V. Kutsenko, E. Sotnikova, Yu.V. Vyatkin, А. A. Zharikova, A. Ershova, M. Zaichenoka, V. Ramensky, O. Skirko, S. Smetnev, O. Kopylova, А. S. Limonova, A. Blokhina, M. S. Pokrovskaya, S. Shalnova, A. N. Meshkov, O. Drapkina
Aim. To validate and evaluate the accuracy of 14 genetic risk scores (GRSs) for type 2 diabetes (T2D), created earlier in other countries, using a Russian population sample from the biobank of the National Medical Research Center for Therapy and Preventive Medicine.Material and methods. For genetic analysis, next generation sequencing data was used on a sample from the Russian population (n=1165) based on the biobank collection. The study included 14 GRSs associated with T2D.Results. The study demonstrated that the predictive power of 12 out of 14 GRSs for T2D was replicated in the Russian population. As quality metrics, we used the area under the ROC curve, which for models including only GRS varied from 54,49 to 59,46%, and for models including GRS, sex and age — from 77,56 to 78,75%.Conclusion. For the first time in Russia, a study of 14 T2D GRSs developed on other populations was conducted. Twelve GRSs have been validated and can be used in the future to improve risk prediction and prevention of T2D in Russia.
{"title":"Validation of genetic risk scores for type 2 diabetes on a Russian population sample from the biobank of the National Medical Research Center for Therapy and Preventive Medicine","authors":"A. Kiseleva, A. G. Soplenkova, V. Kutsenko, E. Sotnikova, Yu.V. Vyatkin, А. A. Zharikova, A. Ershova, M. Zaichenoka, V. Ramensky, O. Skirko, S. Smetnev, O. Kopylova, А. S. Limonova, A. Blokhina, M. S. Pokrovskaya, S. Shalnova, A. N. Meshkov, O. Drapkina","doi":"10.15829/1728-8800-20233746","DOIUrl":"https://doi.org/10.15829/1728-8800-20233746","url":null,"abstract":"Aim. To validate and evaluate the accuracy of 14 genetic risk scores (GRSs) for type 2 diabetes (T2D), created earlier in other countries, using a Russian population sample from the biobank of the National Medical Research Center for Therapy and Preventive Medicine.Material and methods. For genetic analysis, next generation sequencing data was used on a sample from the Russian population (n=1165) based on the biobank collection. The study included 14 GRSs associated with T2D.Results. The study demonstrated that the predictive power of 12 out of 14 GRSs for T2D was replicated in the Russian population. As quality metrics, we used the area under the ROC curve, which for models including only GRS varied from 54,49 to 59,46%, and for models including GRS, sex and age — from 77,56 to 78,75%.Conclusion. For the first time in Russia, a study of 14 T2D GRSs developed on other populations was conducted. Twelve GRSs have been validated and can be used in the future to improve risk prediction and prevention of T2D in Russia.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"1095 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.15829/1728-8800-2023-3843
A. Ershova
.
.
{"title":"Expert opinion on the article \"Assessment of awareness of biobanking among patients and doctors: experience of the Tomsk Oblast\"","authors":"A. Ershova","doi":"10.15829/1728-8800-2023-3843","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3843","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"21 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.15829/1728-8800-2023-3693
O. A. Svitich, V. Zverev, T. Solomay, T. A. Semenenko, A. Nozdracheva, T. P. Gotvyanskaya
Currently, monitoring infectious morbidity, control and forecasting the epidemic process is a topical health problem.Aim. To analyze the capabilities of the biobank for serological monitoring of infectious diseases using the Epstein- Barr virus (EBV), which is associated with infectious mononucleosis, as well as somatic pathology, including cancer.Material and methods. Using the quantitative enzyme- linked immunosorbent assay for specific antibodies to various EBV proteins, we studied blood serum samples from healthy individuals (2010, 2016, 2019, 2020, 2021 and 2022) from the collection of the N. F. Gamaleya National Center of Epidemiology and Microbiology.Results. For the first time, the intensity of EBV epidemic process among apparently healthy adult residents of the capital was assessed using samples of biological material and a biobank information database. At the time of examination, 0,8% of individuals were not infected with EBV, and 9,4% suffered reactivation of a chronic infection. There were no significant changes in detection rate of markers over the years.Conclusion. Certified collections of blood sera can be effectively used to study population immunity, the prevalence of individual infections, population protection nationwide, etc.
目前，监测传染病发病率、控制和预测流行过程是一个热门的健康问题。分析生物库利用与传染性单核细胞增多症有关的爱泼斯坦-巴氏病毒（EBV）对传染病以及包括癌症在内的体细胞病变进行血清学监测的能力。我们使用酶联免疫吸附试验定量检测各种 EBV 蛋白的特异性抗体，研究了 N. F. Gamaleya 国家流行病学和微生物学中心收集的健康人血清样本（2010 年、2016 年、2019 年、2020 年、2021 年和 2022 年）。利用生物材料样本和生物库信息数据库，首次评估了首都表面健康的成年居民中EB病毒流行过程的强度。检查结果显示，0.8% 的人未感染过 EBV，9.4% 的人慢性感染再次复发。多年来，标记物的检出率没有明显变化。经认证的血清采集可有效用于研究人群免疫、个人感染率、全国人口保护等。
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