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Determination of optimal stent length: a survey of urologic surgeons. 最佳支架长度的确定:泌尿外科医生的调查。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 DOI: 10.5173/ceju.2023.83
Justin Kwong, R John D'A Honey, Jason Y Lee, Michael Ordon

Introduction: Ureteral double-J stent length is an important factor affecting stent-related symptoms. Multiple techniques exist to determine ideal stent length for a given patient, however, little is known about what techniques urologists rely on. Our objective was to identify how urologists determine optimal stent length.

Material and methods: An online survey was e-mailed in 2019 to all members of the Endourology Society. The survey sought to assess what methods are commonly used to determine choice of stent length, along with frequency of stent placement post ureteroscopy, duration of stenting, availability of different stent lengths and the use of stent tether.

Results: 301 urologists (15.1%) responded to our survey. Following ureteroscopy, 84.5% of respondents would stent at least 50% of the time. Following uncomplicated ureteroscopy, most respondents (52.0%) would leave a stent for 2-7 days. Patient height was most commonly ranked first as the method of choice in determining stent length (47.0%), followed by estimation based on experience only (20.6%) and intra-operative direct measurement of ureteric length (19.1%). Most respondents utilized multiple methods in determination of optimal stent length. Most respondents (66.5%) were interested in a simple intra-operative technique utilizing a special ureteral catheter that would help choose the most appropriate stent length.

Conclusions: Post-ureteroscopy stent insertion is common and patient height is the most common method of choice used in determining optimal stent length. Most respondents were interested in using a simple, novel ureteral catheter device that would allow them to more accurately select optimal stent length.

导读:输尿管双j型支架长度是影响支架相关症状的重要因素。存在多种技术来确定给定患者的理想支架长度,然而,泌尿科医生所依赖的技术知之甚少。我们的目的是确定泌尿科医生如何确定最佳支架长度。材料和方法:2019年,一项在线调查通过电子邮件发送给了内镜学会的所有成员。该调查旨在评估通常用于确定支架长度选择的方法,以及输尿管镜检查后支架放置的频率,支架放置的持续时间,不同支架长度的可用性以及支架系索的使用。结果:301名泌尿科医师回复我们的调查,占15.1%。输尿管镜检查后,84.5%的回答者至少有50%的时间会支架。无并发症输尿管镜检查后,大多数受访者(52.0%)将支架放置2-7天。患者身高是确定支架长度的首选方法(47.0%),其次是仅根据经验估计(20.6%)和术中直接测量输尿管长度(19.1%)。大多数受访者使用多种方法来确定最佳支架长度。大多数应答者(66.5%)对使用特殊输尿管导管的简单术中技术感兴趣,这将有助于选择最合适的支架长度。结论:输尿管镜后支架置入是常见的,患者身高是确定最佳支架长度最常用的方法。大多数应答者对使用一种简单、新颖的输尿管导管装置感兴趣,这将使他们更准确地选择最佳的支架长度。
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引用次数: 0
High-power laser lithotripsy - do we treat or harm? Histological evaluation of temperature effects in an in vivo study with thulium fiber laser. 高功率激光碎石术-我们是治疗还是伤害?用铥光纤激光器在体内研究温度效应的组织学评价。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 DOI: 10.5173/ceju.2023.24
Angelis Peteinaris, Arman Tsaturyan, Vasiliki Bravou, Vasileios Tatanis, Gabriel Faria-Costa, Konstantinos Pagonis, Solon Faitatziadis, Athanasios Vagionis, Evangelos Liatsikos, Panagiotis Kallidonis

Introduction: The aim of this study was to evaluate the possible histopathological alterations that occur in the kidneys due to a continuous temperature increase above 43°C for one hour of lithotripsy using a newly introduced thulium fiber laser (TFL).

Material and methods: Two female pigs were used. After the insertion of a 9.5/11.5 ureteral access sheath, flexible ureteroscopy and laser lithotripsy for one hour were conducted. A TFL laser with a 200-μm fiber was used. The power setting used was 8 W (0.5 J × 16 Hz). A K-type thermocouple was inserted and fixed in the upper calyx of the right porcine kidney to record the temperature in the pelvicalyceal system during the laser activation. Second-look flexible nephroscopy followed by nephrectomy and pathohistological evaluation of the operated kidney was performed one week after the procedure in the first pig and 2 weeks after the surgery in the second pig.

Results: Flexible nephroscopy did not reveal significant differences between the 2 porcine kidneys. Nevertheless, the histopathological report demonstrated severe alterations in the kidney of the first pig. Mild changes were reported in the kidney of the second pig. A significant improvement in inflammation and haemorrhagic lesions was demonstrated when comparing the 2 kidneys.

Conclusions: The difference demonstrated between the 2 kidneys based on the histopathological report shows that the healing process is capable of improving severe to mild alterations within a one-week time frame. Two weeks after the surgery, only minor changes were observed, suggesting that even temperature increases above the threshold can be tolerated regarding renal damage.

简介:本研究的目的是评估使用新引入的铥光纤激光器(TFL)在43°C以上持续温度升高1小时的碎石术中肾脏可能发生的组织病理学改变。材料与方法:选用母猪2头。植入9.5/11.5输尿管通路鞘后,行输尿管软腔镜及激光碎石1小时。采用光纤长度为200 μm的TFL激光器。使用的功率设置为8w (0.5 J × 16 Hz)。将k型热电偶插入并固定在右猪肾上花萼中,记录激光激活过程中盆骨系统的温度。第1只猪术后1周和第2只猪术后2周分别行第二眼柔性肾镜检查,随后行肾切除术和手术肾的病理组织学评估。结果:柔性肾镜检查显示两种猪肾无明显差异。然而,组织病理学报告显示,第一只猪的肾脏发生了严重的变化。第二只猪的肾脏出现了轻微的变化。当比较两个肾脏时,炎症和出血性病变的显著改善被证明。结论:根据组织病理学报告,两个肾脏之间的差异表明,愈合过程能够在一周的时间框架内改善严重到轻度的改变。手术后两周,仅观察到微小的变化,这表明即使温度升高超过阈值,对于肾脏损害也是可以容忍的。
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引用次数: 0
A giant inguinoscrotal hernia containing urinary bladder repaired with use of robotic-assisted laparoscopy: a case report. 应用机器人辅助腹腔镜修复巨大腹股沟阴囊疝1例。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 DOI: 10.5173/ceju.2023.211
Piotr Kania, Paweł Marczuk, Jakub Biedrzycki

The aim of this report is to underline proper differential diagnosis of scrotal enlargement and to highlight feasibility of minimally invasive robotic-assisted treatment of giant urinary bladder containing inguinoscrotal hernia. A 48-year-old patient was referred to the outpatient urology clinic with diagnosis of hydrocele. During the diagnostic procedures, it was confirmed that the scrotal enlargement is a giant inguinal hernia containing most of the urinary bladder. Robotic-assisted laparoscopic transabdominal preperitoneal hernia repair (TAPP) has been performed. The patient remains asymptomatic after 18 months of observation. Minimally invasive repair should always be considered due to better perioperative and postoperative outcomes.

本报告的目的是强调阴囊肿大的正确鉴别诊断,并强调微创机器人辅助治疗巨大膀胱含腹股沟-阴囊疝的可行性。一个48岁的病人被转介到门诊泌尿科诊所诊断鞘膜积液。在诊断过程中,确认阴囊肿大是一个巨大的腹股沟疝包含了大部分的膀胱。机器人辅助腹腔镜经腹腹膜前疝修补术(TAPP)已经完成。患者观察18个月后仍无症状。由于微创修复术的围手术期和术后预后较好,因此应始终考虑微创修复术。
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引用次数: 1
Review of vasocutaneous fistulas and other rare complications after vasectomy. 输精管切除术后血管皮瘘和其他罕见并发症的回顾。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 Epub Date: 2023-04-30 DOI: 10.5173/ceju.2023.04
Robby P A Lamoury, Jasper Pauwels, Stefan De Wachter, Tim Brits

Introduction: Vasectomy is a surgical procedure for male sterilization. It is a very common procedure in daily urological practice with a low complication rate. Haematoma formation, wound infection, chronic scrotal pain, and spontaneous recanalization are well-known complications. Fistula formation and testicular infarction are less common following a vasectomy. In this article we provide a review of literature regarding rare complications after vasectomy.

Material and methods: A manual electronic search of the PubMed Medline and Web of Science Core Collection databases was performed encompassing all included reports until 30 September 2022 to identify studies that assessed patient complications after a vasectomy.

Results: Urethrovasocutaneous fistulas are by far the most prevalent, while vasocutaneous, vasovenous, and arteriovenous fistulas are seldom reported. In discharging fistulas, a fluid analysis can be done to discriminate different types. In all cases scrotal exploration and ligation of the fistula was performed. If present, an underlying bladder outlet obstruction should be treated. Scrotal infarction is another infrequently reported complication of vasectomy. Diagnosis is made by scrotal ultrasound and colour Doppler. Treatment is usually conservative, but orchiectomy should be considered in larger infarctions. Simple wound infections are common in patients post vasectomy. More complex infections are rare but can result in serious and even fatal complications.

Conclusions: Common complications after vasectomy are well known and usually well discussed with patients. However, rare complications can occur, and it is important that they are recognized by clinicians.

导语:输精管切除术是一种男性绝育手术。这是一种在日常泌尿外科实践中非常常见的手术,并发症发生率低。血肿形成、伤口感染、慢性阴囊疼痛和自发性再通是众所周知的并发症。输精管切除术后瘘管形成和睾丸梗死不太常见。在这篇文章中,我们提供了一篇关于输精管切除术后罕见并发症的文献综述。材料和方法:在2022年9月30日之前,对PubMed Medline和Web of Science核心收藏数据库进行了手动电子搜索,包括所有纳入的报告,以确定评估输精管切除术后患者并发症的研究。结果:尿道-血管皮瘘是迄今为止最常见的,而血管皮瘘、血管静脉瘘和动静脉瘘很少报道。在排出瘘管时,可以进行流体分析以区分不同类型。所有病例都进行了阴囊探查和瘘管结扎。如果存在潜在的膀胱出口梗阻,应进行治疗。阴囊梗死是输精管切除术的另一种罕见并发症。诊断是通过阴囊超声和彩色多普勒。治疗通常是保守的,但在较大的梗死中应考虑睾丸切除术。输精管切除术后患者常见单纯伤口感染。更复杂的感染是罕见的,但可能导致严重甚至致命的并发症。结论:输精管切除术后常见并发症是众所周知的,通常与患者进行充分讨论。然而,可能会出现罕见的并发症,临床医生必须认识到这些并发症。
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引用次数: 1
The effect of pelvic floor muscle training on urodynamic parameters in women with stress urinary incontinence. 盆底肌肉训练对压力性尿失禁女性尿动力学参数的影响。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 Epub Date: 2023-11-13 DOI: 10.5173/ceju.2023.148
Ioannis Tsikopoulos, Lazaros Lazarou, Lazaros Tzelves, Vasileios Sakalis, Christina Papathanasiou, Michael Samarinas

Introduction: Pelvic floor muscle training (PFMT) is suggested for women with stress urinary incontinence (SUI). The aim of our study is to examine the effectiveness of PFMT on urodynamic (UDS) parameters.

Material and methods: This is a prospective observational study enrolling women with SUI. Pelvic surgery, prolapse, body mass index >30, and cognitive disability were exclusion criteria. Patients had baseline UDS, then PFMT only (Group A) or PFMT plus biofeedback (BFD) (Group B) for 6 months and UDS 3 months after treatment. The primary investigated parameters were the number of pads used per day and Valsalva leak point pressure (VLPP).

Results: Forty-six women completed the study, 22 in Group A and 24 in Group B. At baseline, all patients documented SUI with 3 median pads used per day. Urodynamic SUI was documented with a median Valsalva leak point pressure (mVLPP) of 45 cmH2O. At the re-evaluation, 12 women (26.1%) had SUI in BDs with median number pads per day of 1, which was statistically different to baseline (p = 0.02). Urodynamic SUI was reported in 8 (17.4%) women with a mVLPP of 88 cmH2O.Six patients were from Group A and 6 from Group B. In Group A, the median number of pads per day was 1, and urodynamic SUI was found in 3 women. In Group B, the median number of pads per day was 1, and urodynamic SUI was found in 5 women. Thirty-four women (73.9%) were dry - 16 (47.1%) from Group A and 18 (52.9%) from Group B.

Conclusions: PFMT improves urodynamic parameters among women with SUI.

简介:建议患有压力性尿失禁(SUI)的女性进行盆底肌肉训练(PFMT)。我们的研究旨在探讨盆底肌训练对尿动力学(UDS)参数的影响:这是一项前瞻性观察研究,研究对象为患有 SUI 的女性。盆腔手术、脱垂、体重指数大于 30 和认知障碍是排除标准。患者进行基线 UDS,然后只进行 PFMT(A 组)或 PFMT 加生物反馈(BFD)(B 组)治疗 6 个月,并在治疗后 3 个月进行 UDS。主要研究参数为每天使用的尿垫数量和 Valsalva 漏点压力(VLPP):46 名妇女完成了研究,其中 A 组 22 人,B 组 24 人。基线时,所有患者都有 SUI 记录,每天使用的尿垫中位数为 3 个。尿动力学 SUI 的中位 Valsalva 漏点压力(mVLPP)为 45 cmH2O。在再次评估时,有 12 名女性(26.1%)在 BDs 中出现 SUI,每天使用尿垫的中位数为 1 个,与基线有统计学差异(p = 0.02)。A组有6名患者,B组有6名患者。在A组中,每天使用尿垫次数的中位数为1次,3名女性出现了尿动力性 SUI。在 B 组中,每天使用尿垫次数的中位数为 1 次,有 5 名妇女发现了尿动力 SUI。34名妇女(73.9%)为干性,其中A组16人(47.1%),B组18人(52.9%):结论:PFMT 可改善 SUI 女性的尿动力学参数。
{"title":"The effect of pelvic floor muscle training on urodynamic parameters in women with stress urinary incontinence.","authors":"Ioannis Tsikopoulos, Lazaros Lazarou, Lazaros Tzelves, Vasileios Sakalis, Christina Papathanasiou, Michael Samarinas","doi":"10.5173/ceju.2023.148","DOIUrl":"10.5173/ceju.2023.148","url":null,"abstract":"<p><strong>Introduction: </strong>Pelvic floor muscle training (PFMT) is suggested for women with stress urinary incontinence (SUI). The aim of our study is to examine the effectiveness of PFMT on urodynamic (UDS) parameters.</p><p><strong>Material and methods: </strong>This is a prospective observational study enrolling women with SUI. Pelvic surgery, prolapse, body mass index >30, and cognitive disability were exclusion criteria. Patients had baseline UDS, then PFMT only (Group A) or PFMT plus biofeedback (BFD) (Group B) for 6 months and UDS 3 months after treatment. The primary investigated parameters were the number of pads used per day and Valsalva leak point pressure (VLPP).</p><p><strong>Results: </strong>Forty-six women completed the study, 22 in Group A and 24 in Group B. At baseline, all patients documented SUI with 3 median pads used per day. Urodynamic SUI was documented with a median Valsalva leak point pressure (mVLPP) of 45 cmH<sub>2</sub>O. At the re-evaluation, 12 women (26.1%) had SUI in BDs with median number pads per day of 1, which was statistically different to baseline (p = 0.02). Urodynamic SUI was reported in 8 (17.4%) women with a mVLPP of 88 cmH<sub>2</sub>O.Six patients were from Group A and 6 from Group B. In Group A, the median number of pads per day was 1, and urodynamic SUI was found in 3 women. In Group B, the median number of pads per day was 1, and urodynamic SUI was found in 5 women. Thirty-four women (73.9%) were dry - 16 (47.1%) from Group A and 18 (52.9%) from Group B.</p><p><strong>Conclusions: </strong>PFMT improves urodynamic parameters among women with SUI.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"315-321"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of percussion, diuresis and inversion therapy on RIRS success for lower renal pole stones. 叩击、利尿和反转疗法对下肾极结石 RIRS 成功率的影响。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 Epub Date: 2023-11-13 DOI: 10.5173/ceju.2023.189
Caglar Sarioglu, Samet Senel, Emre Uzun, Muhammed Emin Polat, Kazim Ceviz, Oner Odabas, Antonios Koudonas

Introduction: Inversion of the patient, forced diuresis after hydration, and mechanical percussion technique was developed for lower renal pole (LRP) stones with extracorporeal shock wave (ESWL). In this study, we aimed to analyze the effect of percussion, diuresis and inversion (PDI) therapy on the success rates of retrograde intrarenal surgery (RIRS) for the LRP stones.

Material and methods: 114 patients who underwent RIRS for LRP stones <2cm were included in this study. Patients' demographic, clinical, radiological and anatomical features and success status were recorded prospectively. The patients were divided into two groups. One group received RIRS procedure only (non-PDI group) and the other group received PDI therapy after the RIRS procedure (PDI group).

Results: PDI was performed to 60 (52.6%) patients, and not performed to 54 (47.4%) patients. The success rate (58.3%) for the PDI group was higher than the non-PDI group (25.9%), and this difference was statistically significant (p <0.001). In multivariate logistic regression analysis, stone size (OR = 1.306; 95% CI = 1.019-1.674; p <0.001), IU (OR = 1.702; 95% CI = 1.383-2.096; p <0.001) and not performing PDI therapy (p <0.001) OR = 9.455; 95% Cl = 2.426-10.853; p = 0.001) were revealed to be independent risk factors for failure.

Conclusions: PDI therapy increases the success rates of RIRS performed for the LRP stones.

简介:体外冲击波(ESWL)治疗下肾极(LRP)结石的方法包括倒转患者、水化后强制利尿和机械叩击技术。在这项研究中,我们旨在分析叩击、利尿和反转(PDI)疗法对逆行肾内手术(RIRS)治疗 LRP 结石成功率的影响:60例(52.6%)患者接受了PDI治疗,54例(47.4%)患者未接受PDI治疗。PDI 组的成功率(58.3%)高于非 PDI 组(25.9%),且差异具有统计学意义(P 结论:PDI 治疗可提高 LRP 结石的成功率:PDI疗法提高了针对LRP结石实施RIRS的成功率。
{"title":"The effect of percussion, diuresis and inversion therapy on RIRS success for lower renal pole stones.","authors":"Caglar Sarioglu, Samet Senel, Emre Uzun, Muhammed Emin Polat, Kazim Ceviz, Oner Odabas, Antonios Koudonas","doi":"10.5173/ceju.2023.189","DOIUrl":"10.5173/ceju.2023.189","url":null,"abstract":"<p><strong>Introduction: </strong>Inversion of the patient, forced diuresis after hydration, and mechanical percussion technique was developed for lower renal pole (LRP) stones with extracorporeal shock wave (ESWL). In this study, we aimed to analyze the effect of percussion, diuresis and inversion (PDI) therapy on the success rates of retrograde intrarenal surgery (RIRS) for the LRP stones.</p><p><strong>Material and methods: </strong>114 patients who underwent RIRS for LRP stones <2cm were included in this study. Patients' demographic, clinical, radiological and anatomical features and success status were recorded prospectively. The patients were divided into two groups. One group received RIRS procedure only (non-PDI group) and the other group received PDI therapy after the RIRS procedure (PDI group).</p><p><strong>Results: </strong>PDI was performed to 60 (52.6%) patients, and not performed to 54 (47.4%) patients. The success rate (58.3%) for the PDI group was higher than the non-PDI group (25.9%), and this difference was statistically significant (p <0.001). In multivariate logistic regression analysis, stone size (OR = 1.306; 95% CI = 1.019-1.674; p <0.001), IU (OR = 1.702; 95% CI = 1.383-2.096; p <0.001) and not performing PDI therapy (p <0.001) OR = 9.455; 95% Cl = 2.426-10.853; p = 0.001) were revealed to be independent risk factors for failure.</p><p><strong>Conclusions: </strong>PDI therapy increases the success rates of RIRS performed for the LRP stones.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"325-330"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflection points in urology as witnessed by Mark Soloway Part 2: Prostate and kidney cancers. 马克-索洛维见证的泌尿外科拐点 第二部分:前列腺癌和肾癌。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 Epub Date: 2023-11-25 DOI: 10.5173/ceju.2023.3E
Mark S Soloway
{"title":"Inflection points in urology as witnessed by Mark Soloway Part 2: Prostate and kidney cancers.","authors":"Mark S Soloway","doi":"10.5173/ceju.2023.3E","DOIUrl":"10.5173/ceju.2023.3E","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"283-286"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative evaluation of radical prostatectomy using laparoscopic and open method in view of surgical margins 腹腔镜前列腺根治术与开放前列腺根治术在手术边缘的比较分析
Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 DOI: 10.5173/ceju.2023.77
{"title":"A comparative evaluation of radical prostatectomy using laparoscopic and open method in view of surgical margins","authors":"","doi":"10.5173/ceju.2023.77","DOIUrl":"https://doi.org/10.5173/ceju.2023.77","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation after radical prostatectomy in elderly patients - a SEER database-derived competing-risk survival analysis of propensity score-matched age groups. 老年患者根治性前列腺切除术后的放射治疗--对倾向评分匹配年龄组的 SEER 数据库衍生竞争风险生存分析。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 Epub Date: 2023-11-13 DOI: 10.5173/ceju.2023.144
Piotr Zapała, Aleksander Ślusarczyk, Łukasz Zapała, Tomasz Borkowski, Paweł Rajwa, Grzegorz Niemczyk, Piotr Radziszewski

Introduction: This study aimed to evaluate cancer-specific (CSM) and other-cause mortality (OCM) in elderly patients with prostate cancer treated with radical prostatectomy (RP) and postoperative radiotherapy (RT).

Material and methods: The Surveillance, Epidemiology, and End Results (SEER) database was searched for clinically non-metastatic prostate cancer (PCa) treated with RT after RP between 2010 and 2015. Patients were stratified according to age groups and underwent propensity score (PS) matching. The Kaplan-Meier method and competing-risk Cox regression (CRR) were used for survival analysis.

Results: In total, 5385 patients were analysed, including 738 (13.7%) elderly patients (≥70 years old) and 4647 (86.29%) younger individuals. A total of 54 (7.32%) and 69 (9.35%) patients aged ≥70 years died due to PCa and competing reasons, respectively. Among younger patients these included 275 (5.92%) and 208 (4.48%) deaths, respectively. At a median follow-up of 80 months, patients ≥70 years old had significantly shorter OCM (p <0.0001) than PS-matched younger controls without significant impairment of cancer-specific survival when compared to controls (p = 0.19). In CRR analysis older patients were at significantly higher risk of OCM (HR = 2.24, p = 0.0002 and HR = 3.3, p = 0.011 for patients aged ≥70 and ≥75 years, respectively). Simultaneously, the CRR revealed no increased risk of CSM for patients older than 70 and 75 years (HR = 1.2, p = 0.33 and HR = 1.53, p = 0.29, respectively).

Conclusions: Elderly patients with PCa are at high risk of dying due to competing reasons, which might prevent the survival benefit of RT after RP. Selection for salvage and adjuvant RT in these individuals should be cautious.

导言:本研究旨在评估接受根治性前列腺切除术(RP)和术后放疗(RT)治疗的老年前列腺癌患者的癌症特异性死亡率(CSM)和其他原因死亡率(OCM):在监测、流行病学和最终结果(SEER)数据库中搜索了2010年至2015年间接受根治性前列腺切除术(RP)和术后放疗(RT)治疗的临床非转移性前列腺癌(PCa)患者。根据年龄组对患者进行分层,并进行倾向评分(PS)匹配。采用卡普兰-梅耶法和竞争风险考克斯回归法(CRR)进行生存分析:共分析了 5385 名患者,其中包括 738 名(13.7%)老年患者(≥70 岁)和 4647 名(86.29%)年轻患者。共有 54 名(7.32%)和 69 名(9.35%)年龄≥70 岁的患者分别死于 PCa 和其他原因。年轻患者中分别有 275 人(5.92%)和 208 人(4.48%)死亡。在中位随访 80 个月时,≥70 岁患者的 OCM 明显更短(p 结论:≥70 岁患者的 OCM 明显更短(p):老年 PCa 患者因其他原因死亡的风险很高,这可能会阻碍 RP 后 RT 的生存获益。对这些患者选择挽救性和辅助性 RT 时应谨慎。
{"title":"Radiation after radical prostatectomy in elderly patients - a SEER database-derived competing-risk survival analysis of propensity score-matched age groups.","authors":"Piotr Zapała, Aleksander Ślusarczyk, Łukasz Zapała, Tomasz Borkowski, Paweł Rajwa, Grzegorz Niemczyk, Piotr Radziszewski","doi":"10.5173/ceju.2023.144","DOIUrl":"10.5173/ceju.2023.144","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate cancer-specific (CSM) and other-cause mortality (OCM) in elderly patients with prostate cancer treated with radical prostatectomy (RP) and postoperative radiotherapy (RT).</p><p><strong>Material and methods: </strong>The Surveillance, Epidemiology, and End Results (SEER) database was searched for clinically non-metastatic prostate cancer (PCa) treated with RT after RP between 2010 and 2015. Patients were stratified according to age groups and underwent propensity score (PS) matching. The Kaplan-Meier method and competing-risk Cox regression (CRR) were used for survival analysis.</p><p><strong>Results: </strong>In total, 5385 patients were analysed, including 738 (13.7%) elderly patients (≥70 years old) and 4647 (86.29%) younger individuals. A total of 54 (7.32%) and 69 (9.35%) patients aged ≥70 years died due to PCa and competing reasons, respectively. Among younger patients these included 275 (5.92%) and 208 (4.48%) deaths, respectively. At a median follow-up of 80 months, patients ≥70 years old had significantly shorter OCM (p <0.0001) than PS-matched younger controls without significant impairment of cancer-specific survival when compared to controls (p = 0.19). In CRR analysis older patients were at significantly higher risk of OCM (HR = 2.24, p = 0.0002 and HR = 3.3, p = 0.011 for patients aged ≥70 and ≥75 years, respectively). Simultaneously, the CRR revealed no increased risk of CSM for patients older than 70 and 75 years (HR = 1.2, p = 0.33 and HR = 1.53, p = 0.29, respectively).</p><p><strong>Conclusions: </strong>Elderly patients with PCa are at high risk of dying due to competing reasons, which might prevent the survival benefit of RT after RP. Selection for salvage and adjuvant RT in these individuals should be cautious.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 4","pages":"293-299"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiomics vs radiologist in bladder and renal cancer. Results from a systematic review. 放射组学与膀胱癌和肾癌的放射科医生。系统评价的结果。
IF 1.2 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-01-01 DOI: 10.5173/ceju.2023.252
Pietro Tramanzoli, Daniele Castellani, Virgilio De Stefano, Carlo Brocca, Carlotta Nedbal, Giuseppe Chiacchio, Andrea Benedetto Galosi, Rodrigo Donalisio Da Silva, Jeremy Yuen-Chun Teoh, Ho Yee Tiong, Nithesh Naik, Bhaskar K Somani, Vineet Gauhar

Introduction: Radiomics in uro-oncology is a rapidly evolving science proving to be a novel approach for optimizing the analysis of massive data from medical images to provide auxiliary guidance in clinical issues. This scoping review aimed to identify key aspects wherein radiomics can potentially improve the accuracy of diagnosis, staging, and grading of renal and bladder cancer.

Material and methods: A literature search was performed in June 2022 using PubMed, Embase, and Cochrane Central Controlled Register of Trials. Studies were included if radiomics were compared with radiological reports only.

Results: Twenty-two papers were included, 4 were pertinent to bladder cancer, and 18 to renal cancer. Radiomics outperforms the visual assessment by radiologists in contrast-enhanced computed tomography (CECT) to predict muscle invasion but are equivalent to CT reporting by radiologists in predicting lymph node metastasis. Magnetic resonance imaging (MRI) radiomics outperforms radiological reporting for lymph node metastasis. Radiomics perform better than radiologists reporting the probability of renal cell carcinoma, improving interreader concordance and performance. Radiomics also helps to determine differences in types of renal pathology and between malignant lesions from their benign counterparts. Radiomics can be helpful to establish a model for differentiating low-grade from high-grade clear cell renal cancer with high accuracy just from contrast-enhanced CT scans.

Conclusions: Our review shows that radiomic models outperform individual reports by radiologists by their ability to incorporate many more complex radiological features.

简介:放射组学在泌尿肿瘤学中是一门快速发展的科学,被证明是一种新的方法,可以优化医学图像的大量数据分析,为临床问题提供辅助指导。本综述旨在确定放射组学可以潜在提高肾癌和膀胱癌诊断、分期和分级准确性的关键方面。材料和方法:于2022年6月使用PubMed、Embase和Cochrane Central Controlled Register of Trials进行文献检索。如果仅将放射组学与放射学报告进行比较,则纳入研究。结果:共纳入22篇论文,其中膀胱癌4篇,肾癌18篇。放射组学在预测肌肉侵袭方面优于放射科医生在对比增强计算机断层扫描(CECT)中的视觉评估,但在预测淋巴结转移方面与放射科医生的CT报告相当。磁共振成像(MRI)放射组学优于淋巴结转移的放射学报告。放射组学的表现优于放射科医生报告肾细胞癌的可能性,提高了解读者的一致性和表现。放射组学还有助于确定肾脏病理类型的差异,以及恶性病变与良性病变之间的差异。放射组学可以帮助建立一种仅通过增强CT扫描就能高精度区分低级别和高级别透明细胞肾癌的模型。结论:我们的综述表明,放射学模型在合并许多更复杂的放射学特征方面的能力优于放射科医生的个人报告。
{"title":"Radiomics vs radiologist in bladder and renal cancer. Results from a systematic review.","authors":"Pietro Tramanzoli,&nbsp;Daniele Castellani,&nbsp;Virgilio De Stefano,&nbsp;Carlo Brocca,&nbsp;Carlotta Nedbal,&nbsp;Giuseppe Chiacchio,&nbsp;Andrea Benedetto Galosi,&nbsp;Rodrigo Donalisio Da Silva,&nbsp;Jeremy Yuen-Chun Teoh,&nbsp;Ho Yee Tiong,&nbsp;Nithesh Naik,&nbsp;Bhaskar K Somani,&nbsp;Vineet Gauhar","doi":"10.5173/ceju.2023.252","DOIUrl":"https://doi.org/10.5173/ceju.2023.252","url":null,"abstract":"<p><strong>Introduction: </strong>Radiomics in uro-oncology is a rapidly evolving science proving to be a novel approach for optimizing the analysis of massive data from medical images to provide auxiliary guidance in clinical issues. This scoping review aimed to identify key aspects wherein radiomics can potentially improve the accuracy of diagnosis, staging, and grading of renal and bladder cancer.</p><p><strong>Material and methods: </strong>A literature search was performed in June 2022 using PubMed, Embase, and Cochrane Central Controlled Register of Trials. Studies were included if radiomics were compared with radiological reports only.</p><p><strong>Results: </strong>Twenty-two papers were included, 4 were pertinent to bladder cancer, and 18 to renal cancer. Radiomics outperforms the visual assessment by radiologists in contrast-enhanced computed tomography (CECT) to predict muscle invasion but are equivalent to CT reporting by radiologists in predicting lymph node metastasis. Magnetic resonance imaging (MRI) radiomics outperforms radiological reporting for lymph node metastasis. Radiomics perform better than radiologists reporting the probability of renal cell carcinoma, improving interreader concordance and performance. Radiomics also helps to determine differences in types of renal pathology and between malignant lesions from their benign counterparts. Radiomics can be helpful to establish a model for differentiating low-grade from high-grade clear cell renal cancer with high accuracy just from contrast-enhanced CT scans.</p><p><strong>Conclusions: </strong>Our review shows that radiomic models outperform individual reports by radiologists by their ability to incorporate many more complex radiological features.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"76 1","pages":"12-19"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/b8/CEJU-76-252.PMC10091893.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9316747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Central European Journal of Urology
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