Central European Journal of Urology最新文献

Introduction: Prostate cancer is the second most common male cancer worldwide. Its rising incidence and high overtreatment rate drive the search for new prognostic factors. Histopathological variants, such as cribriform pattern (CP), are associated with poorer oncologic outcome. The aim of this study was to assess the correlation between CP in prostate biopsy and radical prostatectomy (RP) and postoperative pathological features.

Material and methods: In this retrospective, single-centre study we analysed the reviewed medical records of 100 men who underwent minimally invasive RP in the years 2017-2019. RP histopathological examination was performed by a single expert pathologist, and preoperative biopsies were assessed by various professionals from different referral centres.

Results: 48% of men underwent endoscopic RP with limited lymphadenectomy, whereas 52% underwent laparoscopic RP with extended lymphadenectomy. CP in biopsy was present in 6 patients: 3 in each of both groups (6.3% and 5.8%, respectively). Lymph node metastases were present in 50% and 10% of patients with and without CP in biopsy, respectively (p = 0.028). Postoperative histopathological examination revealed CP in 65%. CP in RP was associated with higher International Society of Urological Pathology (ISUP) (p < 0.001), extraprostatic extension (EPE) (p = 0.001), seminal vesicle invasion (SVI) (p = 0.001), and positive surgical margin (PSM) (p = 0.004). Thirteen (20%) of the patients with CP in the RP specimen had lymph node metastasis, and none of the patients without CP in the RP specimen had regional LN metastasis.

Conclusions: The presence of CP in a biopsy specimen and RP is associated with negative postoperative features. Therefore, efforts should be made to increase CP reporting in biopsies because its identification could trigger a more radical surgical approach with extended lymphadenectomy.

Introduction: Enuresis (NE) is a socially stigmatising and stressful condition affecting children's and parent's quality of life. The aim of this review was to evaluate and summarize the current knowledge about the pharmacological and non-pharmacological traditional and innovative treatments in children with NE.

Material and methods: We examined the following bibliographic electronic databases: PubMed and the Cochrane Library, from January 2000 until July 2023. The search was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) (8) and was limited to English-language papers that focused on enuresis in patients under 18 years old. Each paper that met the eligibility criteria was reviewed and analyzed in full text by three authors and any discrepancies among them were solved by debate. Due to the heterogeneity of the articles examined, we focused on a qualitative analysis.

Results: Overall, we identified 560 records through database searching. As first step, we excluded 46 articles in non-English language, 6 records whose related articles were not available, 8 articles concerning ongoing trials and 210 duplicated papers. As second step, we eliminated 215 records by evaluating only title and abstract because they did not match the inclusive criteria we mentioned before. Of the remaining 75 studies, we excluded 34 through a further discussion among authors upon the reliability of data. Thus, 41 selected articles were included in the review.

Conclusions: Multiple treatment approaches, both pharmacological and non pharmacological, have been established and validated to reduce signs and symptoms of NE and improve quality of life and the social and emotional discomfort experienced by children. The aim of pediatrician is to identify the right therapy protocol for very single child, evaluating the best approach for him and the family.

Herein, we describe an unusual case of cystoscope damage during a planned laser cystolithotripsy in a 65-year-old male with a previous history of radical prostatectomy for prostate cancer and subsequent serial urethral dilations for bladder neck contracture. Upon crossing the penile urethra without exerting significant pressure, we noticed the cystoscope's distal metallic tip detachment. Therefore, we re-introduced another 22Fr cystoscope and removed the broken part with alligator forceps. Fortunately, no urethral injury or associated complications were noticed on gently re-entering the bladder. Hence, we managed to complete the endoscopic laser cystolithotripsy shortly thereafter. Review of the relevant literature revealed three similar cases. All related to the same manufacturer. Urologists should not lose sight of the fact that such an unexpected instance may tremendously impact the procedure's success, requiring vigilance and adherence to safety protocols.

Introduction: The aim of this study was to investigate the expression of fibrosis-related genes in obstructed ureteral tissue and determine its relationship with biomarkers of renal damage and preoperative renal scan findings.

Material and methods: In all cases, bladder urine and blood samples were collected preoperatively. They were analysed for serum cystatin C, urinary albumin, urinary beta 2 microglobulin, and urinary neutrophil gelatinase-associated lipocalin concentrations, as well as their concentrations standardised by urine creatinine. Pyeloureteral junction obstruction tissue specimens were frozen in liquid nitrogen upon harvesting. RNA was extracted from the samples using TRIzol reagent. qPCR was performed, and the relative expressions of TGFβ1, MMP1, TIMP1, PAI1, CTGF, and VEGFA in stenotic ureteral tissue were calculated. Spearman's rank correlation test was used to calculate the correlation between the relative expression of investigated genes, urine, and blood biomarkers of renal damage and preoperative renal scan findings.

Results: A total of 20 pyeloureteral junctions of 20 patients were harvested at the time of dismembered pyeloplasty. The median age of the patients at the time of the operation was 15.2 [9.07, 66.2] months. There was a significant negative correlation between urinary albumin concentration and relative TGFβ1 expression in pyeloureteral junction tissue (rho = -0.45, p = 0.047), as well as between uAlb and relative VEGFA expression (rho = -0.575, p = 0.008). No correlation with other urine biomarkers of renal damage or renal scan findings was found.

Conclusions: Expression of fibrosis-related genes in the obstructive tissue of the pyeloureteral junction have no direct correlation with biomarkers of renal damage.

Introduction: Laparoscopic adenomectomy for prostates larger than 80 mL is still a topic of debate. The purpose of this study is to evaluate the perioperative outcomes and complications between open Millin (OM) and laparoscopic Millin (LM) adenomectomy.

Material and methods: Perioperative data and complications were retrospectively collected from patients submitted to Millin procedure from August 2019 to August 2022 in a tertiary centre, and OM and LM were compared. Complications were classified according to Clavien-Dindo classification.

Results: A total of 205 patients were identified, 125 in the OM group and 80 in the LM group. Baseline characteristics were similar between the groups. Mean total blood loss (194 ±210 vs 477 ±389 mL, p <0.001), mean haemoglobin drop (1.40 ±1.16 vs 2.62 ±1.42 g/dL, p <0.001), duration of catheterisation (4.63 ±1.39 vs 5.37 ±1.99 days, p = 0.004), and hospital stay (4.59 ±1.72 vs 5.82 ±3.36 days, p = 0.003) were significantly lower in the laparoscopic group. The mean operative time was longer in the laparoscopic group (109.9 ±33.4 vs 68.7 ±18.0 min, p <0.001). The overall complication rate was significantly lower in the laparoscopic group (18.8% vs 36.8%; p = 0.012), and this difference was maintained only in Clavien-Dindo groups I (3.8% vs 13.6%; p = 0.018) and II (12.5% vs 21.6%; p = 0.049). Regarding individual complications, patients in the LM group had significantly less haematuria (1.3% vs 8.8%, p = 0.031), wound infections (0% vs 4.8%, p = 0.047), and blood transfusions (0% vs 6.4%, p = 0.024).

Conclusions: Laparoscopic Miilin adenometomy is a safe technique, with less intraoperative blood loss, shorter length of hospital stay and catheterisation time, and fewer complications, including a lower transfusion rate, than its open counterpart.

Introduction: The aim of this study was to evaluate the outcomes of different urethroplasty procedures as well as two novel techniques, invented in our center, in management of urethral complications after total phallic reconstruction.

Material and methods: Different urethroplasty procedures were conducted according to the urethral pathology for 36 cis-male patients with urethral complications after total phallic reconstruction including meatoplasty, visual internal urethrotomy, staged Johanson urethroplasty utilizing either buccal mucosal graft or skin graft (Tiersche-Duplay principle), non-transecting urethroplasty (Hieneke-Miiklulicz principle), excision and primary anastomosis, as well as two novel techniques: urethral closure under a suprapubic tunnel and abdominal pedicled skin flap urethroplasty. Each patient was routinely evaluated one month after surgery and every 3 months for 12 months, with clinical evaluation, uroflowmetry and post-void residual urine.

Results: With a total of 41 procedures for the 36 patients, 32 patients (88.8 %) could eventually void while standing. The success rate was highest for staged Johanson urethroplasty using split thickness skin graft, staged abdominal pedicled skin flap and excision and primary anastomosis, respectively, while it was lowest for visual internal urethrotomy (0% success) and non-transecting anastomotic urethroplasty (50% success). For staged versus one-stage procedures prospective analysis, 17 out of 26 one-stage procedures (65.4%) succeeded while 13 out of 15 staged procedures (86.6%) succeeded.

Conclusions: Urethral complications following phalloplasty require complex procedures demanding a high level of surgical expertise. Abdominal pedicled skin flap urethroplasty is a viable option for long and recalcitrant urethral strictures.

Introduction: Ureter may be resistant to insertion of ureteral access sheath (UAS) and/or semi-rigid ureterorenoscope because of the narrow ureter, 'difficult ureter' especially in primary retrograde intrarenal surgery (RIRS) cases. We aimed to delineate the parameters that affect significantly the accessibility of the ipsilateral ureter of the stone-bearing patient side.

Material and methods: The data of age, gender, body mass index, comorbidities, prior urinary tract infection, prior stone passage, stone burden, stone density, number of stones, stone localization, surgery side, the presence of hydronephrosis and need for double J (DJ) stent due to difficult ureter for all patients were reviewed. Difficult ureter was defined as the insertion inability of a semi-rigid ureterorenoscope or UAS into the ureter at the surgery side. All patients were divided into two groups as difficult ureter group and non-difficult ureter group.

Results: A total of 454 patients who underwent RIRS for primary kidney stones were included. The incidence of difficult ureter was 7.5% (34/454). The patients in the difficult ureter group were younger. Female gender and prior urinary tract infection rates were higher in the difficult ureter group. Multivariate logistic regression analysis indicated that the factors significantly associated with higher odds of having a difficult ureter in primary RIRS patients were younger age (OR 1.040; 95% CI 1.010-1.070; p = 0.008), female gender (OR 2.859; 95% Cl 1.383-5.908; p = 0.005) and prior urinary tract infection (OR 3.327; 95% CI 1.230-8.999; p = 0.018).

Conclusions: Difficult ureter was associated with younger age at the time of RIRS, female gender and the manifestation of urinary infections in the patient's medical history.