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Neuron-specific enolase of liquor as an objective marker of cognitive impairments in HIV-associated encephalopathy 白酒神经元特异性烯醇化酶作为hiv相关脑病认知障碍的客观标志物
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-2-37-41
Yuliya V. Karakulova, N. E. Seksyaev, D. Sosnin
One of the main causes of cognitive dysfunction in a late stage of HIV infection is HIV-associated encephalopathy. The direct neurotropic impact of HIV creates the pathogenic basis for this clinical syndrome. The purpose — to evaluate the cognitive status and neuron-specific enolase (NSE) level in cerebrospinal fluid (CSF) in HIV-encephalopathy patients. Material and methods. 35 patients were included in the study. They were divided into two groups: 20 patients (9 females and 11 males) with cognitive dysfunction and confirmed diagnosis of HIV/AIDS and 15 patients (6 females and 9 males) were in comparison group. The cognitive status was investigated by mini-mental state examination (MMSE), international HIV-dementia scale (IHDS) and frontal assessment battery (FAB). CSF level of NSE were investigated by ELISA test. Results. Correlation between cognitive dysfunction severity and NSE level in CSF was determined in HIV-encephalopathy patients. Conclusion. NSE level changing in CSF is an objective indicator of clinical severity of HIV-encephalopathy and neurotropic impact of HIV.
HIV感染晚期认知功能障碍的主要原因之一是HIV相关脑病。HIV的直接嗜神经作用为这种临床综合征创造了致病基础。目的:评价hiv -脑病患者脑脊液(CSF)的认知状态和神经元特异性烯醇化酶(NSE)水平。材料和方法。研究纳入了35名患者。将确诊为HIV/AIDS的认知功能障碍患者20例(女9例,男11例)和对照组15例(女6例,男9例)分为两组。采用简易精神状态检查(MMSE)、国际hiv -痴呆量表(IHDS)和正面评估组(FAB)对认知状况进行调查。采用酶联免疫吸附试验(ELISA)检测脑脊液水平。结果。测定hiv -脑病患者脑脊液中NSE水平与认知功能障碍严重程度的相关性。结论。脑脊液中NSE水平变化是反映HIV-脑病临床严重程度和HIV嗜神经影响的客观指标。
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引用次数: 0
To the 50th anniversary of the Department of Hospital Pediatrics of Samara State Medical University 为萨马拉国立医科大学医院儿科系成立50周年
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-1-111-117
G. Makovetskaya, L. Mazur
The article is dedicated to the 50th anniversary of the Hospital Pediatrics Department. The main events in the history of the Department since its foundation in 1973 and the achievements of its members are presented.
这篇文章是献给医院小儿科成立50周年的。介绍了自1973年成立以来该部历史上的主要事件及其成员的成就。
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引用次数: 0
Functional potential of colonization defense of buccal epitheliocytes as an indicator of the clinical course of respiratory tract diseases 口腔上皮细胞定植防御的功能潜力作为呼吸道疾病临床病程的指标
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-1-76-80
O. I. Pikuza, A. M. Zakirova, E. V. Volyanyuk, V. S. Filatov, A. V. Pikuza, A. M. Zakirov
In the structure of children’s morbidity, one of the leading places is occupied by a class of respiratory diseases, which in quantitative terms is formed mainly by acute respiratory infections. The purpose — to investigate and evaluate the indicator significance of the functional potential of colonization defense in respiratory tract diseases.The paper presents the results of a study of colonization resistance indicators using modern research methods (colonization index, artificial colonization of the buccal epithelium and antiadhesive activity of saliva) in 184 patients aged 5 to 18 years with acute bronchitis, recurrent bronchitis and community-acquired pneumonia.Results. In a comparative aspect, the heterogeneity of the colonization level on buccal epitheliocytes of indigenous microflora (oral streptococci) was clearly traced, depending on the topic of the respiratory tract inflammatory lesion. Colonization resistance suffered the most in patients with community-acquired pneumonia. In patients of this group, the colonization index was within 0.89 (0.07) standard units (p < 0.01), which was combined with a pronounced adhesion of Candida albicans on buccal epitheliocytes (r = -0.72). In patients with acute bronchitis, the colonization index was 1.86 (0.21) standard units; with recurrent course of bronchitis – 1.27 (0.19) units (p < 0.01), while the indicators of the control group were 2.03 (0,18). The presence of less typical microorganisms in the oropharynx reflects the weakening of colonization resistance, signaling destabilization processes focused on the mucous membranes level.Conclusion. The deficiency of the mucosal protection functional reserve should be regarded as an unfavorable diagnostic marker of the course of a respiratory infection and the initiation of a bacterial inflammatory process in the respiratory system.
在儿童发病率的结构中,一类呼吸系统疾病占据了主导地位,从数量上看,这类疾病主要是由急性呼吸道感染形成的。目的:探讨和评价定植防御功能势在呼吸道疾病中的指示意义。本文采用现代研究方法对184例5 ~ 18岁急性支气管炎、复发性支气管炎和社区获得性肺炎患者的菌落抗性指标(菌落指数、口腔上皮人工定植和唾液抗粘附活性)进行了研究。在比较方面,根据呼吸道炎症病变的主题,可以清楚地追踪到本地微生物群(口腔链球菌)在口腔上皮细胞上定植水平的异质性。社区获得性肺炎患者菌落耐药性最高。本组患者的定植指数在0.89(0.07)个标准单位以内(p < 0.01),并伴有口腔上皮细胞明显的白色念珠菌粘附(r = -0.72)。急性支气管炎患者的定植指数为1.86(0.21)个标准单位;支气管炎复发组- 1.27(0.19)个单位(p < 0.01),对照组指标为2.03(0.18)。口咽部中不太典型的微生物的存在反映了定植抗性的减弱,表明了粘膜水平上的不稳定过程。粘膜保护功能储备的缺乏应被视为呼吸道感染过程和呼吸系统细菌炎症过程开始的不利诊断标志。
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引用次数: 1
To the 105th anniversary of Kazan school of traumatologists-orthopedists. Transosseous compression-distraction osteosynthesis. Continuing traditions 为喀山创伤矫形医师学校成立105周年干杯。经骨压迫-牵张成骨术。持续的传统
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-3-9-17
I. Pankov, S. D. Sirazitdinov, A. Emelin
The article presents a brief historical sketch of developing the method of transosseous compression-distraction osteosynthesis in Kazan school of traumatologists-orthopedists. The historical roots of Kazan school of traumatologists-orthopedists are shown. Succession of traditions in the work of the School founders is marked. The stages of improving the method of transosseous compression-distraction osteosynthesis are described by the example the works by doctors and researchers of Kazan Scientific-research Institute for traumatology and orthopedics and its successor — Scientific-practical center for trauma at Republic Clinical Hospital.
本文简要介绍喀山创伤骨科学派发展经骨压迫-牵张成骨方法的历史概况。喀山创伤骨科学派的历史根源被展示出来。学校创始人的工作传统的继承是显著的。以喀山创伤骨科科学研究所及其后继的共和国临床医院创伤科学实践中心的医生和研究人员的工作为例,介绍了经骨压迫-牵张成骨法的改进阶段。
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引用次数: 0
On the terms of restoration of finger flexors’ tendons after injury with a profiled metal sheet 异型钢板修复指屈肌腱损伤的研究
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-3-41-44
R. Mullin, R. T. Radkov, D. S. Eflova
The purpose — clinical assessment of the algorithm of terms of the restoration of the finger tendons’ flexor after an injury with a profiled metal sheet. Results. Based on the study results, an algorithm for restorative operations on tendons after an injury with a profiled metal sheet was proposed. When the skin-tendon flap width-to-length ratio is 1:3 or more, one-stage reconstruction of the deep flexor tendon is possible. If the flap width-to-length ratio is less than 1:3, it is necessary to conduct a primary delayed (in 7–10 days) or staged reconstruction of the deep flexor tendon with skin restoration. Conclusion. The presented graphical model of «profiled metal sheet injury» allows giving a clinical assessment of the blood supply to the skin-tendon flap and differentiating treatment of patients with varying degrees of injury severity. In turn, the restoration of normal blood circulation in the injured segment accelerates the healing process, reduces the percentage of complications, and ultimately determines the success of the surgical intervention.
目的:探讨指腱屈肌损伤后金属钢板修复方法的临床评价。结果。在此基础上,提出了一种异型钢板损伤后肌腱修复手术算法。当皮肤腱瓣宽长比为1:3或更多时,可以一期重建深屈肌腱。如果皮瓣宽度与长度比小于1:3,则需要进行一期延迟(7-10天)或分阶段重建深屈肌腱并进行皮肤修复。结论。所提出的“金属板损伤”的图形模型允许对皮肤肌腱皮瓣的血液供应进行临床评估,并对不同程度损伤严重程度的患者进行区分治疗。反过来,损伤节段正常血液循环的恢复加速愈合过程,减少并发症的百分比,并最终决定手术干预的成功。
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引用次数: 0
Contribution of the scientific, medical and public activity of Viktor Konstantinovich Menshikov into the development of Russian pediatrics 维克多·康斯坦丁诺维奇·门希科夫的科学、医学和公共活动对俄罗斯儿科发展的贡献
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-4-143-148
O. I. Pikuza, S. V. Maltsev, A. M. Zakirova, F. Rizvanova, E. Generalova
The article reflects the diverse activity of Prof. V.K. Menshikov as a clinician, a pedagogue, and a researcher. Detailed information is presented about the formation, based on a Kazan children’s hospital, of a new direction in rendering medical assistance to babies and in nutrition science; the contribution of Prof. V.K. Menshikov into training of medical and scientific staff in TASSR and far beyond is shown.
这篇文章反映了V.K. Menshikov教授作为临床医生、教师和研究人员的多样化活动。报告详细介绍了喀山儿童医院在向婴儿提供医疗援助和营养科学方面形成的新方向;V.K. Menshikov教授为培训TASSR及其他地区的医务和科学人员所作的贡献。
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引用次数: 0
Iron deficiency in patients with cardiovascular diseases 心血管疾病患者缺铁
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-2-15-20
N. A. Tarasova, N. R. Khasanov
This review focuses on definition of iron deficiency (ID) in patients with cardiovascular diseases (CVD), pathophysiology of ID in coronary artery disease (CAD) and chronic heart failure (CHF). The currently studied effects of ID therapy in patients with CAD and CHF are highlighted. Most of the published studies demonstrate the negative impact of iron deficiency on the structure and function of the heart, quality of life and prognosis of patients with myocardial infarction (MI) and CHF. The effectiveness of ID correction in patients has been studied extensively, nevertheless there are ongoing studies on the evaluation of efficacy of various parenteral iron forms, as well as on their influence on long-term prognosis in patients with CHF. The correction of iron deficiency reduces the damage and necrosis size in patients with MI, improves left ventricular systolic function and exercise capacity after MI. At the same time, the available data on the ID correction in patients with CHF after myocardial infarction are insufficient and require further study.
本文就心血管疾病(CVD)患者缺铁(ID)的定义、冠状动脉疾病(CAD)和慢性心力衰竭(CHF)患者缺铁的病理生理进行综述。强调了目前研究的ID治疗在CAD和CHF患者中的作用。大多数已发表的研究表明,缺铁对心肌梗死(MI)和CHF患者的心脏结构和功能、生活质量和预后有负面影响。患者ID矫正的有效性已被广泛研究,但目前仍有研究在评估各种肠外铁形式的疗效,以及它们对CHF患者长期预后的影响。缺铁的纠正可减少心肌梗死患者的损伤和坏死大小,改善心肌梗死后左心室收缩功能和运动能力。同时,目前关于心肌梗死后CHF患者ID纠正的资料不足,有待进一步研究。
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引用次数: 1
Clinical case of combined post-COVID syndrome in a child 1例儿童合并covid - 19后综合征临床报告
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-2-115-120
A. Sabitova, I. V. Sitdikova, V. Anokhin, G. R. Fatkullina, G. Kamasheva, V. M. Timasheva
Despite the fact that the new coronavirus infection in children proceeds much milder than in adults, the pediatric practice is facing a problem associated with the general concept of «post-COVID conditions», including Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 and a complex of disease processes with various manifestations, united by the concept of postacute consequences of treatment or hospitalization for SARS-CoV-2 infection (PASC). The article describes a clinical case of combined post-COVID syndrome, in the form of a MIS-C and the subsequent development of PASC in the form of long-term recurrent urticarial rash elements in a 10-year-old child, simulating reactions similar to serum sickness and chronic urticaria.
尽管儿童中的新型冠状病毒感染的进展比成人温和得多,但儿科实践正面临着与“后covid条件”的一般概念相关的问题,包括与COVID-19相关的儿童多系统炎症综合征(MIS-C)以及具有各种表现的疾病过程的复杂性,这些疾病过程与SARS-CoV-2感染治疗或住院后急性后果的概念相结合。本文描述了一名10岁儿童的合并后冠状病毒综合征临床病例,以misc的形式出现,随后以长期复发性荨麻疹元素的形式发展为PASC,模拟类似血清病和慢性荨麻疹的反应。
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引用次数: 0
Features of treatment of the combined functional disorders of gastrointestinal tract in patients who had a new coronavirus infection on an outpatient basis 新型冠状病毒感染患者消化道合并功能障碍门诊治疗特点
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-1-38-41
M. S. Turchinа, M. V. Bukreeva, Zh. E. Annenkova, Yu. M. Morozov, T. I. Obolenskaya
Patients with COVID-19 often suffer from a variety of gastrointestinal disorders. Often this is directly related to the effect of the virus on the epithelial cells of the gastrointestinal tract, as well as the prescription of drugs for the new coronavirus infection treatment. In some patients, gastrointestinal disturbances precede the onset of respiratory symptoms and remain for a long time after recovery, significantly reducing the quality of life. Approximately every second patient who had a COVID-19 infection suffers from stool disorders and dyspeptic symptoms. The most common variant of post-covid lesions of the gastrointestinal tract is functional dyspepsia and irritable bowel syndrome, which outpatient doctors have recently encountered more and more often. In most cases, the attending physician pays more attention to the pulmonary and cardiological manifestations of coronavirus infection, while the symptoms of gastrointestinal lesions are considered minor. The purpose of this article — is to consider possible methods for correcting the functional pathology of the gastrointestinal tract in patients after a COVID-19 infection.
COVID-19患者通常患有各种胃肠道疾病。这通常与病毒对胃肠道上皮细胞的影响以及治疗新型冠状病毒感染的药物处方直接相关。在一些患者中,胃肠道紊乱先于呼吸道症状出现,并在康复后持续很长时间,显著降低了生活质量。大约每两名感染COVID-19的患者中就有一名患有大便紊乱和消化不良症状。新冠肺炎后胃肠道病变最常见的变体是功能性消化不良和肠易激综合征,门诊医生最近遇到的情况越来越多。在大多数情况下,主治医师更关注冠状病毒感染的肺部和心脏学表现,而胃肠道病变的症状则被认为是次要的。本文的目的是考虑纠正COVID-19感染后患者胃肠道功能病理的可能方法。
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引用次数: 1
Treating chronic instability of the acromioclavicular joint 治疗肩锁关节慢性不稳定
Pub Date : 2023-01-01 DOI: 10.32000/2072-1757-2023-3-23-28
R. Salikhov, M. Chekunov, O. Teplov, D. Galimov, V. Solovyev
The acromioclavicular joint is the link between the collarbone and the scapula, responsible for synchronizing movements in the upper shoulder girdle. Chronic instability of the acromioclavicular joint leads to changes in the orientation of the scapula, which provokes kinematic disorders leading to chronic pain. In case of acute dislocation of the acromial end of the clavicle, minimally invasive techniques are usually used, such as fixation with spokes or a hook-shaped plate, or arthroscopic fixation. Surgical techniques for the treatment of patients with acromioclavicular joint chronic symptomatic instability differ significantly from those used to treat patients with acute dislocation of the acromioclavicular joint. In this case, reconstruction of torn ligaments is necessary, because the biological potential of restoring these structures is exhausted after 3–4 weeks. The range of possibilities includes anatomical and non-anatomical techniques, open and minimally invasive procedures using arthroscopy, as well as biological and synthetic transplants. This article presents the authors’ approach to treating such patients and describes the modern reliable surgical technique.
肩锁关节是连接锁骨和肩胛骨的纽带,负责上肩带的同步运动。肩锁关节的慢性不稳定导致肩胛骨方向的改变,从而引起运动紊乱,导致慢性疼痛。对于锁骨肩峰端急性脱位,通常采用微创技术,如用辐条或钩形钢板固定或关节镜固定。治疗肩锁关节慢性症状性不稳定患者的手术技术与治疗急性肩锁关节脱位患者的手术技术有很大不同。在这种情况下,重建撕裂的韧带是必要的,因为恢复这些结构的生物潜力在3-4周后耗尽。可能性的范围包括解剖和非解剖技术,使用关节镜的开放和微创手术,以及生物和合成移植。本文介绍了作者治疗此类患者的方法,并介绍了现代可靠的手术技术。
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引用次数: 0
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中国实用医药
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