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A comprehensive review on metallodrugs in breast cancer treatment 金属药物在乳腺癌治疗中的应用综述
Pub Date : 2023-09-13 DOI: 10.4038/cjs.v52i4.8067
Jatin V. Thake, Manoj R. Kumbhare
It is shocking that breast cancer (BC) now outnumbers lung cancer in terms of global cancer diagnoses. Being deadly to some extent, such a disease’s treatment is crucial. Surgery, radiation therapy, chemotherapy, hormonal therapy, and targeted therapy are just a few of the treatment options available for this condition. By using ligand substitution to alter the current chemical structure or by creating an entirely new element with a higher safety and cytotoxic profile, the metallodrugs are created. Due to their tempting treatment against cancer and their capacity to produce reactive oxygen species (ROS) and reactive nitrogen species (RNS), which cause oxidative damage and cellular death, metals are extremely efficient in the fight against cancer. The whole list of recently found complexes (in vivo/vitro), their mode of action against the tumour, and the mechanical information gathered by various scientists have all been discussed in the following paragraphs. This review highlights the research that has been conducted over the past 22 years by many experts and provide comprehensive information regarding the use of metals as a medicine for the treatment of BC. Also, this review covers a variety of prospective metal therapies down the line with their success stories.
令人震惊的是,就全球癌症诊断而言,乳腺癌(BC)的数量现在超过了肺癌。这种疾病在某种程度上是致命的,治疗是至关重要的。手术、放射治疗、化疗、激素治疗和靶向治疗只是治疗这种疾病的几种选择。通过使用配体取代来改变现有的化学结构,或者通过创造一个具有更高安全性和细胞毒性的全新元素,金属药物就被创造出来了。由于它们对癌症的诱人治疗以及它们产生活性氧(ROS)和活性氮(RNS)的能力,导致氧化损伤和细胞死亡,金属在对抗癌症方面非常有效。最近发现的复合物(体内/体外)的全部列表,它们对肿瘤的作用模式,以及由不同科学家收集的机械信息,都在以下段落中进行了讨论。这篇综述强调了许多专家在过去22年中进行的研究,并提供了关于使用金属作为治疗BC的药物的全面信息。此外,本综述涵盖了各种前瞻性金属疗法的成功案例。
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引用次数: 0
Community awareness and perceptions on microplastics: a case study from Sri Lanka 社区对微塑料的认识和看法:来自斯里兰卡的案例研究
Pub Date : 2023-09-13 DOI: 10.4038/cjs.v52i4.8134
K. Premarathna, S. P. Abeysundara, A. M. T. A. Gunaratne, H. M. S. P. Madawala
Microplastic (MP) pollution is a global issue due to its unprecedented impacts on the environment and human health. However, its place as a potential pollutant and possible impacts on plant and human health are less understood among the general public. The study was conducted to investigate the level of awareness of MP pollution and its impacts and to evaluate their practices and perceptions of plastic usage, and their awareness on regulatory measures in Sri Lanka. The convenience sampling method was employed to select the study population representative of both rural and urban areas. A questionnaire was distributed among 166 respondents belonging to the age group of 20 - 40 years. Nearly 67% and 68% of respondents were aware of MPs and their harmful impacts, respectively. Nevertheless, most respondents (66 %) were not aware of the regulatory measures introduced by the authorities to control the usage of plastic products. About 66% of respondents discarded plastic items on a daily or weekly basis indicating their widespread usage among the general public in Sri Lanka. However, a majority (85%) were unaware that burning of plastics is a prohibited action in the country. The results revealed that the awareness of MPs and their impacts were significantly linked to the gender, level of education, and occupation of respondents, though their awareness on regulatory measures did not show any relationship with the tested demographic characteristics. Unemployed respondents (98.4%) were more mindful of the non-biodegradable nature of plastics than that of students and employed respondents, indicating that the level of education has no link with their awareness of plastics and their characteristics. Despite reasonably high awareness on MPs, the study highlights the necessity of introducing effective strategies to enhance the awareness of regulatory measures to control plastic usage and safe disposal mechanisms among the general public to manage MP pollution in Sri Lanka.
微塑料污染对环境和人类健康造成了前所未有的影响,是一个全球性问题。然而,公众对其作为一种潜在污染物的地位以及对植物和人类健康可能产生的影响知之甚少。该研究旨在调查斯里兰卡民众对塑料污染及其影响的认识程度,并评估他们对塑料使用的做法和看法,以及他们对斯里兰卡监管措施的认识。采用方便抽样法,选取具有农村和城市代表性的研究人群。对166名年龄在20至40岁之间的受访者分发了一份问卷。近67%和68%的受访者分别了解国会议员及其有害影响。然而,大多数受访者(66%)并不知道当局为控制塑料制品的使用而采取的监管措施。约66%的受访者每天或每周都会丢弃塑料制品,这表明斯里兰卡公众普遍使用塑料制品。然而,大多数人(85%)不知道焚烧塑料在该国是被禁止的行为。结果显示,国会议员的意识及其影响与受访者的性别、教育水平和职业显著相关,尽管他们对监管措施的认识与所测试的人口统计学特征没有任何关系。失业的受访者(98.4%)比学生和就业的受访者更关注塑料的不可生物降解性,这表明受教育程度与他们对塑料及其特性的认识无关。尽管对塑料污染的认识相当高,但该研究强调了引入有效战略的必要性,以提高公众对控制塑料使用的监管措施和安全处置机制的认识,以管理斯里兰卡的塑料污染。
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引用次数: 0
Coastal developments and Sea turtle conservation: Effect of artificial light on female nesting behaviours and hatchling post-emergence migrations 海岸发展与海龟保育:人造光对雌海龟筑巢行为及孵化后迁徙的影响
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8212
R. S. Rajakaruna
No abstract available
没有摘要
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引用次数: 0
Effects of foliar application of Fermented Fish Waste Solution from yellowfin tuna (Thunnus albacares) on growth and yield of MI-2 chilli (Capsicum annuum) 叶面施用黄鳍金枪鱼发酵鱼废液对MI-2型辣椒生长和产量的影响
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8073
A. F. Shama, J. Nimalan
Yellowfin tuna is the most popular fish species consumed by Sri Lankans, and the majority of waste generated during processing is not utilized properly. The waste of this species has been identified as a rich source of amino acids and micro-nutrients which are essential for plant growth, but they are dumped into the ocean, or disposed in landfills leading to pollution. The study was conducted to prepare a fermented fish waste solution (FFWS) from yellowfin tuna and evaluate its efficiency on the growth and yield of MI-2 chilli crops. The FFWS solution was prepared by using fish waste from yellowfin tuna and jaggery in a 1:1 ratio and kept for about 21 days for fermentation in a cool and well-ventilated location. The filtrate of FFWS was applied separately as a foliar spray in different concentrations (2.5%, 5% and 7.5%) on chilli plants (n = 10 per treatment) once in a week with a negative control. The height of the plants, number of leaves and number of branches were measured, and the number of flowers and fruits were counted weekly until the first harvest. According to the findings, crops subjected to FFWS started flowering earlier and showed better growth and yield than control crops. Overall, plants treated with 5% and 7.5% of FFWS promoted growth and yield similarly, without significant differences. According to the research results, the application of the 5% FFWS is a more cost-effective and affordable choice than the application of the 7.5% FFWS. Further study and commercialization of FFWS foliar fertilizer may promote environmentally-friendly agriculture and the effective use of fish waste, as well as provide better solutions for the current scenario in Sri Lanka to reduce the usage of synthetic fertilizer.
黄鳍金枪鱼是斯里兰卡人最常食用的鱼类,加工过程中产生的大部分废物没有得到适当利用。该物种的废物已被确定为植物生长所必需的氨基酸和微量营养素的丰富来源,但它们被倾倒到海洋中,或被处理在垃圾填埋场导致污染。以黄鳍金枪鱼为原料制备发酵鱼粪液,并评价其对MI-2型辣椒作物生长和产量的影响。将黄鳍金枪鱼鱼粪与粗浆按1:1的比例配制成FFWS溶液,在阴凉通风处发酵21天左右。FFWS滤液以不同浓度(2.5%、5%和7.5%)分别喷施于辣椒(n = 10,每次处理),每周1次,阴性对照。测量植株的高度、叶片数量和枝条数量,每周计算花和果实的数量,直到第一次收获。结果表明,与对照作物相比,经FFWS处理的作物开花时间更早,生长和产量更好。总体而言,5%和7.5%的FFWS处理对植株生长和产量的促进作用相似,无显著差异。研究结果表明,使用5%的FFWS比使用7.5%的FFWS更具成本效益和可承受性。FFWS叶面肥料的进一步研究和商业化可以促进环境友好型农业和鱼类废物的有效利用,并为斯里兰卡目前的情况提供更好的解决方案,以减少合成肥料的使用。
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引用次数: 0
The quantum of polycyclic aromatic hydrocarbon in Pyxicephalus edulis and sediments in Oluwa river, Igbekebo area, Ondo state, Nigeria 尼日利亚Ondo州Igbekebo地区Oluwa河中Pyxicephalus edulis和沉积物中多环芳烃的数量
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8205
Thompson F. Ediagbonya, F. Ikuesan, Akinsanmi M. Oyeyemi, J. A. Ogunjobi, O. E. Omoyugbo
Polycyclic aromatic hydrocarbons (PAHs) are organic compounds composed of two or more fused aromatic rings. PAHs can be found in a variety of foods and beverages, including drinking water, vegetables, fruits, cereals, oils, seafood, and meats. The current study investigated the pollution levels of the quantum of polycyclic aromatic hydrocarbon in Pyxicephalus edulis and river sediments. Twenty-five sediment samples and male and female specimens of Pyxicephalus edulis were collected from Oluwa River near Igbekebo, Ondo State Nigeria. The sediment samples were then dried in the open air for three days while the identified frog species were dried separately for 6 hours at 105°C before being powdered. The physicochemical parameters of sediment samples examined using standard physical and chemical analytical techniques and polycyclic aromatic hydrocarbons in frog and sediment samples were examined using gas chromatographyflame ionization analysis (GC-FID). The toxicity equivalent(TEQ) values of PAHs in sediment samples were determined by comparing the findings of this study to the Sediment Quality Guideline (SQG) with effects range from viz., low (ERL), median(ERM) and threshold-effects level (TEL)/probable-effects level (PEL) to assess the toxicity of PAHs to aquatic organisms living in sediments. Male frogs had significantly higher concentrations of Acenaphthylene, Phenanthrene, Anthracene, Pyrene, and total PAHs than females, and lower concentrations of Naphthalene, Acenaphthylene, Fluorene, and Fluoranthene. BaAnt, Benzo(b) fluoranthene, Benzo(k)fluoranthrene, Benzo(a)pyrene, Indeno(1,2,3-cd) pyrene, Dibenz(a,h)anthracene, Benzo(g,h,i)perylene were reported only among males. The cause of this variation is unknown, but it could be due to differences in the genetic make-up of male and female frogs.
多环芳烃是由两个或多个稠环组成的有机化合物。多环芳烃存在于各种食品和饮料中,包括饮用水、蔬菜、水果、谷物、油、海鲜和肉类。目前的研究调查了墨西哥Pyxicephalus edulis和河流沉积物中多环芳烃的污染水平。从尼日利亚翁多州Igbekebo附近的Oluwa河采集了25份沉积物样本以及墨西哥扁头鱼的雄性和雌性样本。然后将沉积物样品在露天干燥三天,同时将已鉴定的青蛙物种在105°C下单独干燥6小时,然后制成粉末。采用标准理化分析技术对沉积物样品的理化参数进行了检测,并采用气相色谱-火焰离子化分析(GC-FID)对青蛙和沉积物样品中的多环芳烃进行了检测。沉积物样品中多环芳烃的毒性当量(TEQ)值是通过将本研究结果与沉积物质量指南(SQG)进行比较来确定的,其影响范围为低(ERL)、中(ERM)和阈值影响水平(TEL)/可能影响水平(PEL),以评估多环芳烃对生活在沉积物中的水生生物的毒性。雄蛙的亚萘酚、菲、蒽、芘和总PAHs浓度显著高于雌蛙,萘、亚萘基、芴和荧蒽浓度较低。BaAnt、苯并(b)芴、苯并芴、苯并(a)芘、茚并(1,2,3-cd)芘、二苯并(a,h)蒽和苯并(g,h,i)苝仅在男性中报道。这种变异的原因尚不清楚,但可能是由于雄性和雌性青蛙基因构成的差异。
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引用次数: 0
Pyrolysis as a value added method for plastic waste management: A review on converting LDPE and HDPE waste into fuel 热解作为塑料废物管理的一种增值方法:LDPE和HDPE废物转化为燃料的综述
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8026
P. G. I. Uthpalani, J. K. Premachandra, D. S. M. De Silva, V. P. A. Weerasinghe
The global demand for plastic is increasing year by year due to its indispensable uses and excellent properties. Plastic wastes persist for many years due to their slow deterioration and cause severe environmental problems. Therefore, there is a growing focus worldwide on plastic waste disposal methods to overcome adverse environmental impacts. As plastics are petroleum-based materials, the pyrolysis of plastics to fuel oil, gases, and char, has more concern than the other plastic waste management methods of recycling and landfilling. A yield of 70-80 wt.% of liquid fuel from pyrolysis waste has been reported elsewhere, emerging the importance and aptness of this method in plastic waste management. The common reactor types for the pyrolysis process are batch reactor, semi-batch reactor, spouted bed reactor, and fluidized bed reactor.  The common catalysts employed in plastic pyrolysis were zeolites, including ZSM-5, HUSY, Zeolite X, and Y. The pore structure and the catalyst’s acidity are the most influencing parameters in increasing the liquid yield and the quality of the oil produced in the pyrolysis process. This paper reviews the existing literature on pyrolysis processes developed for HDPE and LDPE wastes globally and their governing factors. Furthermore, emissions in the pyrolysis process and engine combustion of the fuel oil, performance, and emission characteristics were discussed. Although plastic waste separation prior to its management is a challenging process, this review highlights the conversion of waste plastic into energy as a smart way to meet the rising demands.
由于其不可缺少的用途和优异的性能,全球对塑料的需求逐年增加。塑料垃圾因其降解缓慢而存在多年,造成严重的环境问题。因此,全世界越来越关注塑料废物的处理方法,以克服不利的环境影响。由于塑料是石油基材料,与回收和填埋等其他塑料废物管理方法相比,将塑料热解为燃料油、气体和木炭更受关注。70- 80wt .%的液体燃料的产率从热解废物已被报道在其他地方,新兴的重要性和这种方法在塑料废物管理的适用性。热解过程常用的反应器类型有间歇式反应器、半间歇式反应器、喷淋床反应器和流化床反应器。塑料热解常用的催化剂为沸石,包括ZSM-5、HUSY、X型沸石和y型沸石。其中,孔隙结构和催化剂酸度是提高热解产液率和产油质量影响最大的参数。本文综述了国内外关于HDPE和LDPE废弃物热解工艺及其影响因素的文献。此外,还讨论了燃料油在热解过程和发动机燃烧过程中的排放、性能和排放特征。尽管塑料废物在管理之前进行分类是一个具有挑战性的过程,但本综述强调,将废塑料转化为能源是满足日益增长的需求的一种明智方式。
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引用次数: 1
Growth responses of genetically diverse rice (Oryza sativa L.) cultivars to Arsenic stress 遗传多样性水稻品种对砷胁迫的生长反应
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8206
Sammani Manawasinghe, R. Chandrajith
Although arsenic (As) is a toxic element for plant growth, it can accumulate in rice plants to higher levels. A case-control experiment was carried out to investigate the impact of As in soil on rice plant growth. Nine (9) different native and improved rice cultivars were grown in soils with 10 mg/kg As. Total As content in grains was quantified using an ICP-MS. The mean As content in control samples was 15.8 µg/kg while As treatment samples showed 122 µg/kg. Grains of improved rice variety of Bg 300 showed the highest As accumulation. The chlorophyll content declined by 28% under As stress and 56% tiller losses were also observed. The significant reduction of plant growth has given an impaired grain yield under As-treated conditions. Soil arsenic also showed a significant impact on Ni, Rb, and Ba uptake and accumulation. This study showed that As accumulation in rice is cultivar-dependent and also indicated a drastic reduction of the yield under elevated As levels. The native cultivar, Kahawanu was shown the lowest As-accumulation (90.1 mg/kg) under elevated As within the nine rice cultivars. So it can be identified as the best resistance cultivar for the As stress. The results can be utilized for developing high-tolerance rice varieties using new breeding technologies.
尽管砷(As)对植物生长是一种有毒元素,但它可以在水稻中积累到更高的水平。采用病例对照试验研究了土壤中砷对水稻生长的影响。九(9)个不同的本地和改良水稻品种在含有10 mg/kg As的土壤中生长。使用ICP-MS对谷物中的总As含量进行定量。对照样品中砷的平均含量为15.8µg/kg,而砷处理样品中砷含量为122µg/kg。水稻改良品种Bg300的籽粒砷积累量最高。砷胁迫下叶绿素含量下降28%,分蘖损失56%。在砷处理条件下,植物生长的显著减少导致粮食产量下降。土壤砷对Ni、Rb和Ba的吸收和积累也有显著影响。这项研究表明,砷在水稻中的积累是依赖于品种的,也表明在高砷水平下产量会急剧下降。在9个水稻品种中,本地品种Kahawanu在As升高的情况下表现出最低的As积累(90.1 mg/kg)。因此,可以确定其为抗砷胁迫的最佳品种。研究结果可用于利用新的育种技术开发高耐受性水稻品种。
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引用次数: 0
Potential of iron-based superconductors (IBS) in future applications 铁基超导体(IBS)未来应用的潜力
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8047
T. D. B. Liyanagedara, C. N. Nupearachchi, C. A. Thotawatthage
Due to the expansion of research studies in the family of new superconductors, there is a progress in the investigations of basic physical and chemical properties. The new findings certainly ended the cuprate monopoly in high temperature superconductor (HTSC) family with the introduction of iron based chemical structures. The possessed high values of superconductor temperatures (TC) in iron-based superconductors (IBS) provide hints of novel approaches to futuristic applications while deepening the knowledge of high temperature superconductivity. Up-to-date, many theoretical and practical methods are being utilized to investigate new IBS.
由于新超导体家族研究的扩展,在基本物理和化学性质的研究方面取得了进展。随着铁基化学结构的引入,这一新发现无疑结束了高温超导体(HTSC)家族中铜酸盐的垄断地位。铁基超导体(IBS)中超导体温度(TC)的高值为未来的应用提供了新的途径,同时加深了对高温超导性的认识。到目前为止,许多理论和实践方法正在被用来研究新的IBS。
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引用次数: 0
Abundance and diversity of phytoplankton and zooplankton in selected village tanks in Vavuniya, Sri Lanka 斯里兰卡瓦武尼亚选定村庄水箱中浮游植物和浮游动物的丰度和多样性
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8077
R. A. D. Samarawickrama, A. Nanthakumaran, P. Sivakumar, S. Saravanan
The abundance and diversity of planktons in selected village tanks namely Peraru, Nochchimoddai and Mamaduwa in the Vavuniya district were studied from March to April, 2021. The objectives of the study were to identify the phyto- and zooplanktons, and to estimate their abundance and diversity in the selected village tanks. Planktons were sampled weekly using a plankton net. Based on the morphological features, samples were initially identified up to the genus level using standard keys and their respective abundance was estimated using Sedgewick- rafter counting cell. Simultaneously, water samples were also collected at each location to determine the water quality parameters such as dissolved oxygen, electrical conductivity, pH, turbidity, temperature, and, nitrate and phosphate concentrations. The results showed that there were 16 genera of Chlorophyceae, six genera of Bacillariophyceae and seven genera of Cyanophyceae, while three species of Copepods, one species of Cladocerans and 10 species of Rotifers were identified. The dominant phytoplanktons belonged to Bacillariophyceae, and represented about 50% of total population of phytoplanktons while Cyanophyceae as the least abundant. Copepods were dominant in Peraru and Nochchimoddai tanks, representing more than 50% of the total zooplankton population while Rotifers were dominant in Mamaduwa village tank, with a 58% of total zooplankton population.
于2021年3月至4月对瓦武尼亚地区选定的村庄池Peraru、Nochchimoddai和Mamaduwa的浮游生物丰度和多样性进行了研究。研究的目的是确定选定的村庄池中的浮游植物和动物,并估计它们的丰度和多样性。浮游生物每周用浮游生物网取样。根据形态特征,用标准键对样品进行属级初步鉴定,并用Sedgewick- rafter计数细胞对样品的丰度进行估计。同时,在每个地点采集水样,确定水质参数,如溶解氧、电导率、pH、浊度、温度、硝酸盐和磷酸盐浓度。结果表明,该海域共鉴定出绿藻门16属、硅藻门6属、蓝藻门7属,桡足类3种、枝大洋类1种、轮虫类10种。硅藻科浮游植物占优势,约占总浮游植物数量的50%,蓝藻科数量最少。Peraru和Nochchimoddai池以桡足类为主,占总浮游动物种群的50%以上;Mamaduwa村池以轮虫为主,占总浮游动物种群的58%。
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引用次数: 0
Serum Aldosterone in patients with Chronic Kidney Disease of uncertain etiology in Girandurukotte and Wilgamuwa, Sri Lanka 斯里兰卡吉兰杜鲁科特和威尔加穆瓦病因不明的慢性肾脏病患者血清醛固酮
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8043
B. Fernando, T. W. Hettiarachchi, T. Sudeshika, Z. Badurdeen, N. Erandika, N. Nanayakkara
The Renin Angiotensin Aldosterone System (RAAS) is the main regulator of body fluid and electrolyte balance in the human body. Features of RAAS activation, such as hypertension and fluid retention, are not apparent in some categories of CKD-like tubular interstitial diseases. The beneficial effects of RAAS blockers are controversial if not activated.  This study was conducted to identify the features of RAAS activation in CKDu and to evaluate the representativeness of Aldosterone as a marker of activation. A cross-sectional study was conducted on 119 definite CKDu patients at the renal clinics in Girandurukotte and Wilgamuwa, Sri Lanka. The basic biochemical parameters, serum electrolytes, and osmolality were measured by using serum and urine samples of the participants. Statistical analysis was performed in IBM SPSS statistics version 23. Only 4.4% and 6.7% of study subjects had increased serum Aldosterone and serum Angiotensin II. There was a significant positive correlation between serum Aldosterone with serum creatinine (r=0.477, p<0.01) and Angiotensin II (r=0.379, p<0.01). Inversely, it was negatively correlated with eGFR (r=-0.353, p<0.01). Moreover, serum aldosterone had a significant elevation in the late stages (p=0.024) than early stages and was significantly associated with proteinuria (p=0.032).  Results showed no indications of activated RAAS in patients with the diagnosis of definite CKDu. A significant number of the population had hypernatremia which is positively correlated with hyperosmolality, indicating dehydration.  The possibility of subclinical dehydration that may have an effect with faster progression.
肾素-血管紧张素-醛固酮系统(RAAS)是人体体液和电解质平衡的主要调节因子。RAAS激活的特征,如高血压和液体滞留,在某些类型的CKD样肾小管间质疾病中并不明显。RAAS阻断剂如果不被激活,其有益效果是有争议的。本研究旨在确定CKDu中RAAS激活的特征,并评估醛固酮作为激活标志物的代表性。在斯里兰卡吉兰杜鲁科特和威尔加穆瓦的肾脏诊所对119名明确的CKDu患者进行了横断面研究。通过使用参与者的血清和尿液样本测量基本生化参数、血清电解质和渗透压。统计分析在IBM SPSS statistics version 23中进行。只有4.4%和6.7%的受试者血清醛固酮和血清血管紧张素II升高。血清醛固酮与血清肌酐(r=0.477,p<0.01)和血管紧张素II(r=0.379,p<0.01)呈正相关,与eGFR呈负相关(r=-0.353,p<0.01),血清醛固酮在晚期比早期显著升高(p=0.024),并与蛋白尿显著相关(p=0.032)。结果显示,在诊断为CKDu的患者中,没有激活RAAS的迹象。大量人群患有高钠血症,这与高渗性呈正相关,表明脱水。亚临床脱水的可能性,可能对更快的进展产生影响。
{"title":"Serum Aldosterone in patients with Chronic Kidney Disease of uncertain etiology in Girandurukotte and Wilgamuwa, Sri Lanka","authors":"B. Fernando, T. W. Hettiarachchi, T. Sudeshika, Z. Badurdeen, N. Erandika, N. Nanayakkara","doi":"10.4038/cjs.v52i3.8043","DOIUrl":"https://doi.org/10.4038/cjs.v52i3.8043","url":null,"abstract":"The Renin Angiotensin Aldosterone System (RAAS) is the main regulator of body fluid and electrolyte balance in the human body. Features of RAAS activation, such as hypertension and fluid retention, are not apparent in some categories of CKD-like tubular interstitial diseases. The beneficial effects of RAAS blockers are controversial if not activated.  This study was conducted to identify the features of RAAS activation in CKDu and to evaluate the representativeness of Aldosterone as a marker of activation. A cross-sectional study was conducted on 119 definite CKDu patients at the renal clinics in Girandurukotte and Wilgamuwa, Sri Lanka. The basic biochemical parameters, serum electrolytes, and osmolality were measured by using serum and urine samples of the participants. Statistical analysis was performed in IBM SPSS statistics version 23. Only 4.4% and 6.7% of study subjects had increased serum Aldosterone and serum Angiotensin II. There was a significant positive correlation between serum Aldosterone with serum creatinine (r=0.477, p<0.01) and Angiotensin II (r=0.379, p<0.01). Inversely, it was negatively correlated with eGFR (r=-0.353, p<0.01). Moreover, serum aldosterone had a significant elevation in the late stages (p=0.024) than early stages and was significantly associated with proteinuria (p=0.032).  Results showed no indications of activated RAAS in patients with the diagnosis of definite CKDu. A significant number of the population had hypernatremia which is positively correlated with hyperosmolality, indicating dehydration.  The possibility of subclinical dehydration that may have an effect with faster progression.","PeriodicalId":9894,"journal":{"name":"Ceylon Journal of Science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41391551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Ceylon Journal of Science
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