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Catalytic derivatization of 2-Aminobenzo[d]thiazole for observing antibacterial activity and in silico analysis 2-氨基苯并[d]噻唑的催化衍生化及其抑菌活性观察和硅分析
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8095
S. Bepary, B. K. Biswas, F. M. Nazia, S. Islam, T. S. Juthy
2-Aminobenzo[d]thiazoles have been converted to corresponding acetanilides and 2-hydroxy compounds for observing antibacterial activities. The acetylation was done by direct use of acetic acid, whereas the corresponding 2-hydroxy derivative was synthesized following various reaction conditions with or without a catalyst for observing the associated yield and ease of the reaction. In this study, the reaction yield was found to be between 20% and 86%. The synthesized acetanilides and the 2-hydroxy compounds were screened for antibacterial activity against various common pathogenic gram-positive and gram-negative organisms. Encouraging antimicrobial potential was noted from these small molecules. Finally, the compounds were taken for in silico analysis to observe the possible orientations in the binding site of the alanine racemase enzyme of Enterococcus faecalis.
2-氨基苯并[d]噻唑被转化为相应的乙酰苯胺和2-羟基化合物,以观察抗菌活性。直接用乙酸进行乙酰化反应,在不同的反应条件下合成相应的2-羟基衍生物,观察反应的产率和难易程度。在本研究中,发现反应收率在20% ~ 86%之间。对合成的乙酰苯胺及其2-羟基化合物进行了抗菌活性筛选,测定其对多种常见致病性革兰氏阳性和革兰氏阴性菌的抑菌活性。从这些小分子中发现了令人鼓舞的抗菌潜力。最后,对化合物进行硅晶分析,观察粪肠球菌丙氨酸消旋酶结合位点的可能取向。
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引用次数: 0
A quality review of EIA: A comparative study of state-funded and International Aid Agency funded development projects in Sri Lanka 环境影响评估的质量审查:斯里兰卡国家资助和国际援助机构资助发展项目的比较研究
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8021
V. Ravi, N. Vimaladhas, V. Vimaladhas
Environmental Impact Assessment (EIA) is a tool for mitigating the effects of developmental projects on the environment and promoting sustainable development. EIA is an expensive, and professionally engaged process that involves the public. Many countries around the world have long-standing laws in place connected to this topic, as well as solid knowledge and experience. One persistent argument against the efficacy of EIA in developing nations is that the procedure and quality differ from country to country. The International Aid Agencies (IAA) have their guidelines for protecting the environment while following local environmental assessment standards for any financing requirements. IAA involvement in the EIA process might significantly affect how well-written EIA reports are. To evaluate the assessment quality, six EIA reports from state-financed development projects (SL-EIAs) and another six development projects EIAs funded by the IAA (IAA-EIAs) in Sri Lanka were randomly chosen. LeeCooley review package (1990) was used to evaluate the Environmental Impact Statements (EIS) of each EIA. In this investigation, it was discovered that IAA-EIAs and SL-EIAs had a significant difference in overall quality. IAA-EIAs show values that range from highly satisfactory to satisfactory and each share 50 percent, whereas SL-EIAs indicate 83% satisfactory and 17 % of borderline quality. In comparison to the SL-EIAs, all four review areas of the IAA-EIAs performed notably well. While the SL-EIA shows good to borderline quality (0.66-0.72), all evaluated IAA-EIA reports reveal highly satisfactory to satisfactory (0.81-0.93) quality. The engagement of IAA in the environmental assessment has a considerable impact to improve assessment quality in comparison to the only domestic assessment. Finding the weak area in the SL-EIA process and adhering to the IAA standards would elevate the standard of the report.
环境影响评估是一种减轻开发项目对环境影响和促进可持续发展的工具。环境影响评估是一个涉及公众的昂贵且专业的过程。世界上许多国家都有与这一主题相关的长期法律,以及扎实的知识和经验。反对发展中国家环境影响评估有效性的一个持续论点是,各国的程序和质量不同。国际援助机构(IAA)制定了保护环境的指导方针,同时遵守当地环境评估标准以满足任何融资要求。IAA参与环评过程可能会严重影响环评报告的编写质量。为了评估评估质量,随机选择了来自斯里兰卡国家资助开发项目(SL EIA)的六份环评报告和由IAA资助的另外六份开发项目(IAA EIA)。LeeColley审查包(1990年)用于评估每个环评的环境影响报告(EIS)。在本次调查中,发现IAA EIA和SL EIA在总体质量上存在显著差异。IAA EIA显示的值从非常令人满意到令人满意,各占50%,而SL EIA显示83%令人满意,17%为临界质量。与SL环境影响评价相比,IAA环境影响评价的所有四个审查领域都表现良好。虽然SL-EIA显示出良好至临界质量(0.66-0.72),但所有评估的IAA-EIA报告显示出高度满意至令人满意(0.81-0.93)的质量。与唯一的国内评估相比,IAA参与环境评估对提高评估质量具有相当大的影响。发现SL-EIA过程中的薄弱环节并遵守IAA标准将提高报告的标准。
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引用次数: 0
Agent-based modelling of electric vehicle behaviour in a university environment 基于Agent的大学环境下电动汽车行为建模
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8089
S. K. Jaslin, M. A. U. S. Navaratne, J. B. Ekanayake
As the number of electric vehicles (EVs) increases, the strategic planning of charging infrastructure becomes a crucial matter. Vehicle parking time takes the longest at home and work. The residential is responsible for 75% of EV charging time, while the workplace is for 14%. The combination of EVs with intermittent energy sources has attracted considerable attention in recent years. It has several advantages, including significantly greening the entire EV usage cycle and attaining financial viability by lowering the direct peak demand on the grid. This study has described the agent-based infrastructure of the EV charging station model on university premises. It lets us obtain the best possible energy supply from solar PV, external batteries, and grid agents. Three charging scenarios (uncontrolled, vehicle-to-grid (V2G), and grid-to-vehicle (G2V)) are constructed and simulated with varying percentages of EV resemblance. Slow charging is included in the G2V scenario to improve the PV benefits in the EV charging model. The simulation result shows that slow charging in the workplace infrastructure increases the PV benefits of EV charging while reducing grid dependency.
随着电动汽车数量的增加,充电基础设施的战略规划变得至关重要。在家和工作中停车时间最长。住宅占电动汽车充电时间的75%,而工作场所占14%。近年来,电动汽车与间歇性能源的结合引起了相当大的关注。它有几个优点,包括显著绿化整个电动汽车使用周期,并通过降低电网的直接峰值需求来实现财务可行性。本研究描述了大学校园电动汽车充电站模型的基于代理的基础设施。它使我们能够从太阳能光伏、外部电池和电网代理获得尽可能好的能源供应。构建并模拟了三种充电场景(非受控、车辆到电网(V2G)和电网到车辆(G2V)),具有不同百分比的电动汽车相似性。G2V场景中包括慢速充电,以提高电动汽车充电模式中的光伏效益。仿真结果表明,工作场所基础设施中的慢速充电增加了电动汽车充电的光伏效益,同时减少了对电网的依赖。
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引用次数: 0
Junior secondary students’ satisfaction of basic psychological needs and their achievement in physics 初中生基本心理需求的满足与物理成绩
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8071
P. Vijayakumaran, P. Liyanage, W. Chandrasena
Self-Determination Theory (SDT) is a broad theory of human development and wellness, with strong implications in education. According to SDT, three psychological needs are essential settings for self-growth, integrity and well-being viz., competence, autonomy, and relatedness (CAR). This study investigates the relations of junior secondary students’ physics achievement with the satisfaction of their Basic Psychological Needs (CAR). A mixed methods approach was used in the study and selected a convenience sample of 855 junior secondary students and 8 principals in all five educational zones in Jaffna District in the North Province, Sri Lanka. The student related quantitative data were collected using standard Korean Basic Psychological Needs Scale (K-BPNS) with four-point Likert scale and assessment test papers for each Grade. Qualitative data were gathered in interviews from eight principals to explore their views on current situation of physics teaching-learning processes according to the framework for comprehending motivation in SDT. Quantitative data were analysed descriptively using SPSS 20.0. Qualitative data were analysed in narrative analysis. The results revealed that students’ satisfaction with BPN (CAR) factors were directly correlated with their achievement in physics.  Principals’ perception on Reeve’s student-teacher dialectical frame is not at a satisfactory level. Thus, this study provides essential information for policymakers on enhancing students’ physics achievement at the junior secondary school level.
自我决定理论(SDT)是一个关于人类发展和健康的广泛理论,在教育中有着重要的意义。根据SDT,三种心理需求是自我成长、完整性和幸福感的基本条件,即能力、自主性和相关性(CAR)。本研究调查了初中生物理成绩与基本心理需求(CAR)满意度的关系。本研究采用混合方法,从斯里兰卡北部省贾夫纳区所有五个教育区的855名初中生和8名校长中选择了一个方便的样本。使用标准的韩国基本心理需求量表(K-BPNS)和四点Likert量表以及每个年级的评估试卷收集学生相关的定量数据。通过对八位校长的访谈,收集定性数据,根据SDT中理解动机的框架,探讨他们对物理教学过程现状的看法。定量数据采用SPSS 20.0进行描述性分析。叙述分析中对定性数据进行了分析。结果表明,学生对BPN(CAR)因素的满意度与物理成绩直接相关。校长们对里夫师生辩证框架的认识并不尽如人意。因此,本研究为决策者提供了提高学生初中物理成绩的重要信息。
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引用次数: 0
Effect of extraction temperature on the phytochemicals, minerals and antioxidant properties of Telfairia occidentalis leaf extracts 提取温度对西葫芦叶提取物植物化学成分、矿物质及抗氧化性能的影响
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8207
A. J. Awoniyi, O. Ogunmola, O. Babatunde, O. M. Daniel
Telfairia occidentalis leaves are known to possess many therapeutic potentials such as antidiabetic, anti-inflammatory, anticholesterolemic etc. To maximize their use in phytomedicine, the conditions used in preparation methods are crucial. Therefore, this study estimated the effect of extraction temperature on the phytochemicals, minerals, and antioxidant properties of T. occidentalis leaves. The powdered samples of T. occidentalis leaves were extracted using water at 1000C and 250C, respectively, followed by the phytochemical, mineral and antioxidant analyses of the plant extracts. The concentration of most constituent metabolites in the cold extract of T. occidentalis leaves was significantly (p < 0.05) higher than that of the hot extract. The highest mineral concentrations in hot and cold extracts of T. occidentalis leaves were sodium (2.22 mg/L) and potassium (2.77 mg/L), respectively. In the antioxidant study, the EC50  values (131.20 ± 1.70 μg/ml and 105.08 ± 0.54 μg/ml) of the hot extract of T. occidentalis leaves were significantly (p < 0.05) lower than those of the cold extract (228.17 ± 23.03 μg/ml and 151.47 ± 14.68 μg/ml). The study reveals that the extracts hold varying biological importance. The cold aqueous extract can be an excellent nutritional adjuvant for the supply of essential nutrients, whereas the hot aqueous extract can act as an important agent in ameliorating pathological conditions thrive on excessive free radical generation. Therefore, the different extraction procedures can be utilized based on the desired biological outcome.
众所周知,西花叶具有许多治疗潜力,如抗糖尿病、抗炎、抗胆固醇血症等。为了最大限度地将其用于植物医学,制备方法中使用的条件至关重要。因此,本研究估计了提取温度对西洋T.occidentalis叶片的植物化学物质、矿物质和抗氧化性能的影响。分别在1000摄氏度和250摄氏度下用水提取西洋T.occidentalis叶的粉末样品,然后对植物提取物进行植物化学、矿物和抗氧化分析。西洋T.occidentalis叶冷提取物中大多数成分代谢产物的浓度显著高于热提取物(p<0.05)。西洋T.occidentalis叶冷热提取物中的最高矿物质浓度分别为钠(2.22mg/L)和钾(2.77mg/L)。在抗氧化研究中,西洋T.occidentalis叶热提取物的EC50值(131.20±1.70μg/ml和105.08±0.54μg/ml)显著低于冷提取物(228.17±23.03μg/ml和151.47±14.68μg/ml)(p<0.05)。研究表明,这些提取物具有不同的生物学重要性。冷水提取物可以是一种极好的营养佐剂,用于提供必需的营养素,而热水提取物可以作为一种重要的试剂,用于改善过度自由基生成的病理条件。因此,可以根据所需的生物学结果使用不同的提取程序。
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引用次数: 0
Antivenoms for local effects of snake envenoming  抗蛇毒毒素
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8209
Umesha Madhushani, G. Isbister, W. Hodgson, S. Siribaddana, Anjana Silva
Snake envenoming is a significant public health issue that disproportionately affects the poorest communities in the tropical regions. There is a spectrum of local effects following snakebite, including pain, swelling, bluish discolouration, haemorrhagic blistering, local tissue necrosis and gangrene at the bite site. In severe local envenomings, significant tissue loss and impaired function can occur and may result in permanent disability in snakebite survivors. Although the mainstay of hospital treatment for snake envenoming is antivenom, its effectiveness for local effects remains contentious.  The preclinical efficacy of antivenoms against the local effects of envenoming is examined with a range of in-vivo and in-vitro tests. Most of these tests are only capable of examining the ability of the antivenom to prevent, rather than reverse, the local effect. A limitation of the above tests is that they do not consider venom pharmacokinetics or the time course of irreversible effects in envenomed humans. Therefore, more clinically relevant experimental models of antivenom efficacy are required. We searched MEDLINE for studies on the local effects of snakebite. The current clinical literature on the effectiveness of antivenom for local effects appears to be limited. We identified only two randomised trials that compared antivenom with placebo and six randomised trials that tested the effectiveness of one antivenom or one dosage regimen of an antivenom compared to another antivenom or different dosage of antivenom for preventing or reversing the local effects. All these studies were on viperine envenomings. In addition, several studies without a control/comparative group have commented on antivenom effectiveness, although they invariably have significant bias. The existing studies had contrasting conclusions, including no effect of antivenom, antivenom halting the progression of local effects, early antivenom preventing the occurrence of severe local effects including necrosis, early antivenom leading to faster functional improvement, antivenom accelerating the resolution of local effects, or no conclusion. Future research needs to focus on well-designed studies investigating whether the early administration of antivenom will prevent severe local effects.
蛇毒是一个重大的公共卫生问题,对热带地区最贫穷社区的影响尤为严重。蛇咬伤后会出现一系列局部症状,包括疼痛、肿胀、蓝色变色、出血性水泡、咬伤部位局部组织坏死和坏疽。在严重的局部中毒中,可能会发生严重的组织损失和功能受损,并可能导致蛇咬伤幸存者的永久残疾。虽然医院治疗蛇中毒的主要方法是抗蛇毒血清,但其对局部效果的有效性仍然存在争议。抗蛇毒血清抗局部蛇毒作用的临床前疗效是通过一系列体内和体外试验来检验的。这些测试大多只能检测抗蛇毒血清预防而不是逆转局部效应的能力。上述试验的一个局限性是,它们没有考虑毒液的药代动力学或中毒人体中不可逆作用的时间过程。因此,需要更多临床相关的抗蛇毒血清疗效实验模型。我们在MEDLINE搜索有关蛇咬伤局部影响的研究。目前关于抗蛇毒血清局部效果的临床文献似乎是有限的。我们只确定了两项比较抗蛇毒血清与安慰剂的随机试验,以及六项随机试验,测试了一种抗蛇毒血清或一种抗蛇毒血清的一种剂量方案与另一种抗蛇毒血清或不同剂量的抗蛇毒血清在预防或逆转局部效应方面的有效性。所有这些研究都是关于毒蛇毒液的。此外,一些没有对照/比较组的研究已经评论了抗蛇毒血清的有效性,尽管它们总是有明显的偏见。现有的研究得出了截然不同的结论,包括抗蛇毒血清没有作用,抗蛇毒血清阻止局部效应的进展,早期抗蛇毒血清预防严重局部效应的发生,包括坏死,早期抗蛇毒血清导致更快的功能改善,抗蛇毒血清加速局部效应的消退,或没有结论。未来的研究需要集中在精心设计的研究上,调查抗蛇毒血清的早期施用是否会防止严重的局部效应。
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引用次数: 0
Effect of ocean circulation and chlorophyll-a concentration on yellowfin tuna catch rates in Sri Lankan logline fishery 海洋环流和叶绿素a浓度对斯里兰卡对数线渔业黄鳍金枪鱼捕捞率的影响
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8208
U. S. Maddumage, J. Rajapaksha, J. Gunatilake
Sri Lanka has access to fishery resources in the Indian Ocean due to its location. While traditional fishing methods are still used in the Sri Lankan fishery industry, modern technologies such as remote sensing and GIS are employed to determine spatiotemporal distribution of tuna fish resources in the offshore fishery industry. However, due to uncertain catch rates, Sri Lankan fishers report low catch per unit effort, leading to increased fishing duration to meet targeted catch. Potential fishing areas can be identified based on oceanographic conditions to reduce search time and improve efficiency, particularly for highly migratory species like yellowfin tuna. Therefore, this study is focused on identifying the impact of subsurface ocean currents and chlorophyll-a concentration on yellowfin tuna aggregations. The study analysed fishery and oceanographic data from January 2018 to December 2019 within a latitudinal range of 0°N to 20°N and a longitudinal range of 70°E to 90°E. The data were gridded at a resolution of 0.25 degrees and then matched for analysis. The generalized additive model (GAM) and the empirical cumulative distribution function (ECDF) were applied to identify the nature of relationships between CPUE and the oceanographic conditions. The results showed high tuna aggregations occurred in chlorophyll-a concentration between 0.3– 0.4 mg/m3 and current speed less than 0.4 m/s at a depth of 60 – 75 m of Sri Lankan longliners. Yellowfin tuna fishable aggregations were available throughout the year, although the spatial distribution of yellowfin tuna varied depending on the prevailing oceanographic conditions. Thus, searching for fishing locations based on oceanographic factors is essential for successful fishing operations. Hence, tuna harvest can be enhanced by maintaining fishing areas and the longline depth according to the oceanographic factors.
由于地理位置的关系,斯里兰卡可以获得印度洋的渔业资源。在斯里兰卡渔业仍采用传统捕捞方法的同时,利用遥感和GIS等现代技术确定近海渔业金枪鱼资源的时空分布。然而,由于渔获率不确定,斯里兰卡渔民报告的单位努力渔获量较低,导致为达到目标渔获量而增加的捕捞时间。可以根据海洋学条件确定潜在的捕鱼区域,以减少搜索时间和提高效率,特别是对黄鳍金枪鱼等高度洄游物种。因此,本研究的重点是确定海底洋流和叶绿素-a浓度对黄鳍金枪鱼聚集的影响。该研究分析了2018年1月至2019年12月的渔业和海洋学数据,纬度范围为0°N至20°N,纵向范围为70°E至90°E。将数据以0.25度的分辨率网格化,然后进行匹配分析。应用广义加性模型(GAM)和经验累积分布函数(ECDF)分析了CPUE与海洋条件之间的关系。结果表明,在60 ~ 75 m深的斯里兰卡延绳钓上,当叶绿素a浓度在0.3 ~ 0.4 mg/m3之间,流速小于0.4 m/s时,金枪鱼大量聚集。黄鳍金枪鱼的可捕捞种群全年都有,但黄鳍金枪鱼的空间分布因当时的海洋学条件而异。因此,根据海洋学因素寻找捕鱼地点对成功的捕鱼作业至关重要。因此,可根据海洋学因素,通过维持捕捞面积和延绳钓深度来增加金枪鱼的收获。
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引用次数: 0
The rainbow vertex connection number of ladder graphs and Roach graphs 阶梯图和罗奇图的彩虹顶点连接数
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8045
W. D. D. P. Dewananda, K. K. K. R. Perera
A vertex-coloured graph G is said to be rainbow vertex-connected, if every two vertices of G are connected by a path whose internal vertices have distinct colours. The rainbow vertex-connection number of a connected graph G, denoted by rvc(G), is the smallest number of colours that are needed to make G, a rainbow vertex-connected. This study focuses on deriving formulas for the rainbow vertex connectivity number of a simple ladder graph and a roach graph.
如果G的每两个顶点都由一条内部顶点具有不同颜色的路径连接,则称顶点着色图G是彩虹顶点连接的。连通图G的彩虹顶点连通数,用rvc(G)表示,是使G(彩虹顶点连通)所需的最小颜色数。本文着重推导了简单梯形图和罗奇图的彩虹顶点连通数的计算公式。
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引用次数: 0
Biofilm Enriched rock phosphate as a potential phosphorous fertilizer to replace triple super phosphate in rice cultivation: A preliminary field trial 富生物膜磷矿肥作为替代三元超磷肥的潜在磷肥:初步田间试验
Pub Date : 2023-09-01 DOI: 10.4038/cjs.v52i3.8091
J. Jayaneththi, G. Seneviratne, H. Madawala, M. G. T. S. Amarasekara
Rock Phosphate (RP), derived from natural apatite mined from Eppawala (ERP), is identified as a possible substitute for Triple Super Phosphate (TSP). However, its application is limited due to low solubility. If the bio-solubility is enhanced, ERP can be used as a phosphorous (P) fertilizer for annual crops. The present study focused on using an effective biofilm formulation identified after screening several known phosphate solubilizing biofilms, and introducing a biofilm-enriched ERP (BEE) as an alternative for TSP in rice cultivation. Two field trials were conducted in two consecutive seasons, dry season in 2018 (Yala) and the wet in 2018/2019 (Maha). The existing chemical fertilizer dosage (CF) recommended for rice by the Department of Agriculture (DOA) was modified by fully replacing TSP-P with BEE, along with 65% nitrogen (N) and potassium (K) fertilizers (CFNK). Three different rates of BEE, 65, 80 and 100% (equivalent to TSP-P recommended by the DOA) were tested (CFNK + 65 BEE, CFNK + 80 BEE and CFNK + 100 BEE) against CF. Results revealed that the rate of 100% BEE performed better than that of other rates of BEE (65% and 80%), while the same recorded significantly higher grain yields in both seasons compared to all other treatments. Moreover, plant growth parameters viz. shoot and root dry masses, height, and panicle length were also recorded higher values with CFNK + 100BEE application than the control (CF). Therefore, the BEE can be suggested as an alternative to TSP for rice cultivation, with an added advantage of using a reduced dosage of N and K fertilizers. However, further studies are needed to test the BEE under different soil and climatic conditions in the country.
从Eppawala(ERP)开采的天然磷灰石中提取的岩石磷酸盐(RP)被认为是三重超级磷酸盐(TSP)的可能替代品。然而,由于溶解度低,其应用受到限制。如果生物溶解度提高,ERP可以用作一年生作物的磷(P)肥料。本研究的重点是使用一种有效的生物膜制剂,该制剂是在筛选了几种已知的溶磷生物膜后确定的,并引入了富含生物膜的ERP(BEE)作为水稻种植中TSP的替代品。连续两个季节进行了两次田间试验,分别是2018年的旱季(亚拉)和2018/2019年的雨季(马哈)。农业部(DOA)为水稻推荐的现有化肥剂量(CF)进行了修改,用BEE完全取代了TSP-P,以及65%的氮(N)和钾(K)肥料(CFNK)。对CFNK+65 BEE、CFNK+80 BEE和CFNK+100 BEE三种不同的BEE处理率(相当于DOA推荐的TSP-P)进行了对比试验。结果表明,100%BEE处理的效果优于其他BEE处理(65%和80%),同时与所有其他处理相比,两个季节的粮食产量都显著较高。此外,施用CFNK+100BEE的植物生长参数,即地上部和根部干物质、高度和穗长,也比对照(CF)记录到更高的值。因此,BEE可以作为TSP的替代品用于水稻种植,还具有使用减少剂量的N和K肥料的额外优势。然而,还需要进一步的研究来测试该国不同土壤和气候条件下的BEE。
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引用次数: 0
Wind power calculation based on sums of diffusion method and a novel power curve approximation model 基于扩散求和法和一种新的功率曲线近似模型的风电功率计算
Pub Date : 2023-06-01 DOI: 10.4038/cjs.v52i2.8023
H. Bandarathilake, G. Palamakumbura
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引用次数: 0
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Ceylon Journal of Science
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