Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2024.01.007
Xiangmei Xiong , Zheng Liu , Xiance Che , Xuemin Zhang , Xia Li , Wenyuan Gao
Raspberries are used for both food and medicine, but it has not yet attracted widespread attention. In this paper, the chemical constituen of the original plant raspberry. R. chingii is one of the new “Zhe Bawei” medicinal materials selected in 2017. “Zhe Bawei” refers to eight kinds of genuine medicinal materials in Zhejiang Province. The chemical constituents, pharmacological effects, processing, and application of Rubus chingii Hu were reviewed to provide a reference for its further development. Relevant literature in recent years was collected in databases such as China Knowledge Network, Web of Science, Elsevier, PubMed, and X-Mol, using “raspberry”, “Rubus chingii”, “traditional use”, “chemical composition”, “pharmacology”, etc. as keywords individually or in combination. The summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep enough. More in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry industry. In the future, with the participation of more researchers, it is expected to develop innovative drugs based on raspberry for the treatment of diseases.
树莓既可食用又可入药，但尚未引起广泛关注。本文介绍了原植物覆盆子的化学成分。覆盆子是2017年新入选的 "浙八味 "药材之一。"浙八味 "是指浙江省八种道地药材。通过对胡颓子的化学成分、药理作用、加工工艺、应用等方面进行综述，为胡颓子的进一步开发提供参考。以 "覆盆子"、"茜草"、"传统用途"、"化学成分"、"药理 "等为关键词，单独或组合检索了中国知网、Web of Science、Elsevier、PubMed、X-Mol 等数据库中近年来的相关文献。对药理活性的总结表明，树莓药理活性之间的关系还不够深入。应在此方向开展更深入的研究，探索其有效成分的作用机理，为树莓产业的进一步发展提供有效参考。未来，在更多研究人员的参与下，有望开发出基于树莓治疗疾病的创新药物。
{"title":"Chemical composition, pharmacological activity and development strategies of Rubus chingii: A review","authors":"Xiangmei Xiong , Zheng Liu , Xiance Che , Xuemin Zhang , Xia Li , Wenyuan Gao","doi":"10.1016/j.chmed.2024.01.007","DOIUrl":"10.1016/j.chmed.2024.01.007","url":null,"abstract":"<div><p>Raspberries are used for both food and medicine, but it has not yet attracted widespread attention. In this paper, the chemical constituen of the original plant raspberry. <em>R. chingii</em> is one of the new “Zhe Bawei” medicinal materials selected in 2017. “Zhe Bawei” refers to eight kinds of genuine medicinal materials in Zhejiang Province. The chemical constituents, pharmacological effects, processing, and application of <em>Rubus chingii</em> Hu were reviewed to provide a reference for its further development. Relevant literature in recent years was collected in databases such as China Knowledge Network, Web of Science, Elsevier, PubMed, and X-Mol, using “raspberry”, “<em>Rubus chingii</em>”, “traditional use”, “chemical composition”, “pharmacology”, etc. as keywords individually or in combination. The summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep enough. More in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry industry. In the future, with the participation of more researchers, it is expected to develop innovative drugs based on raspberry for the treatment of diseases.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 313-326"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000480/pdfft?md5=f5c10511ebcf7e1ecf6aae89412b6265&pid=1-s2.0-S1674638424000480-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2023.03.006
Joseph Sakah Kaunda , Jia Liu , Yaojun Xu , Yuansi Chen , Chenfang Yue , Xingjie Zhang , Ruihan Zhang , Muhammad Amin , Weilie Xiao , Hongliang Li , Xiaoli Li
<div><h3>Objective</h3><p>To study constituents of the leaves of <em>Macaranga hemsleyana</em>, and evaluate their inhibitory effects against NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation, and antiproliferative activity.</p></div><div><h3>Methods</h3><p>The constituents were isolated and purified by column chromatography on MCI gel CHP20P/P120, silica gel, Sephadex LH-20, and HPLC. The structures of compounds were determined by 1D, 2D NMR, and HR-ESI-MS data. The inhibitory effect of compounds on inflammasome activation was determined by lactate dehydrogenase (LDH) procedure. The antiproliferative activity was evaluated using MTT assay.</p></div><div><h3>Results</h3><p>The study led to the isolation of 23 compounds, including one new compound, identified as (2<em>Z</em>)-3-[4-(<em>β</em>-<em>D</em>-glucopyranosyloxy)-2′-hydroxy-5′-methoxyphenyl]-2-propenoic acid (<strong>1</strong>), together with 22 known compounds recognized as 1,4-dihydro-4-oxo-3-pyridinecarbonitrile (<strong>2</strong>), methyl 4-methoxynicotinate (<strong>3</strong>), 4-methoxynicotinonitrile (<strong>4</strong>), 1-(3-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranosyl-4,5-dihydroxyphenyl)-ethanone (<strong>5</strong>), neoisoastilbin (<strong>6</strong>), isoastilbin (<strong>7</strong>), aromadendrin <strong>(8</strong>), neoastilbin (<strong>9</strong>), astilbin (<strong>10</strong>), quercitrin (<strong>11</strong>), neoschaftoside (<strong>12</strong>), apigenin 6,8-bis-<em>C</em>-<em>α</em>-<em>L</em>-arabinoside (<strong>13</strong>), vitexin (<strong>14</strong>), bergenin (<strong>15</strong>), scopoletin (<strong>16</strong>), glucopyranoside salicyl (<strong>17</strong>), koaburside (<strong>18</strong>), benzyl <em>β</em>-<em>D</em>-glucoside (<strong>19</strong>), icariside B5 (<strong>20</strong>), roseoside (<strong>21</strong>), loliolide (<strong>22</strong>), and adenosine (<strong>23</strong>). The tested compounds did not show LDH inhibition nor antiproliferative activity.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new glycoside. Compounds <strong>2</strong> and <strong>3</strong> were obtained for the first time from natural source. The 22 known compounds constituted of alkaloids (<strong>2</strong>–<strong>4</strong>, <strong>23</strong>), phenolics (<strong>5</strong>, <strong>15</strong>, <strong>17</strong>, <strong>18</strong>), flavonoids (<strong>6</strong>–<strong>14</strong>), coumarin (<strong>16</strong>), benzyl glycoside (<strong>19</strong>), and norsesquiterpenes (<strong>20</strong>–<strong>22</strong>). All the compounds, <strong>1</strong>–<strong>23</strong>, were revealed from <em>M. hemsleyana</em> for the first time. This is the initial uncovering of molecules <strong>1</strong>–<strong>10</strong>, <strong>12</strong>, <strong>13</strong>, <strong>17</strong>–<strong>19</strong>, and <strong>23</strong> from the genus <em>Macaranga</em>. The isolated compounds
{"title":"Constituents from leaves of Macaranga hemsleyana","authors":"Joseph Sakah Kaunda , Jia Liu , Yaojun Xu , Yuansi Chen , Chenfang Yue , Xingjie Zhang , Ruihan Zhang , Muhammad Amin , Weilie Xiao , Hongliang Li , Xiaoli Li","doi":"10.1016/j.chmed.2023.03.006","DOIUrl":"10.1016/j.chmed.2023.03.006","url":null,"abstract":"<div><h3>Objective</h3><p>To study constituents of the leaves of <em>Macaranga hemsleyana</em>, and evaluate their inhibitory effects against NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation, and antiproliferative activity.</p></div><div><h3>Methods</h3><p>The constituents were isolated and purified by column chromatography on MCI gel CHP20P/P120, silica gel, Sephadex LH-20, and HPLC. The structures of compounds were determined by 1D, 2D NMR, and HR-ESI-MS data. The inhibitory effect of compounds on inflammasome activation was determined by lactate dehydrogenase (LDH) procedure. The antiproliferative activity was evaluated using MTT assay.</p></div><div><h3>Results</h3><p>The study led to the isolation of 23 compounds, including one new compound, identified as (2<em>Z</em>)-3-[4-(<em>β</em>-<em>D</em>-glucopyranosyloxy)-2′-hydroxy-5′-methoxyphenyl]-2-propenoic acid (<strong>1</strong>), together with 22 known compounds recognized as 1,4-dihydro-4-oxo-3-pyridinecarbonitrile (<strong>2</strong>), methyl 4-methoxynicotinate (<strong>3</strong>), 4-methoxynicotinonitrile (<strong>4</strong>), 1-(3-<em>O</em>-<em>β</em>-<em>D</em>-glucopyranosyl-4,5-dihydroxyphenyl)-ethanone (<strong>5</strong>), neoisoastilbin (<strong>6</strong>), isoastilbin (<strong>7</strong>), aromadendrin <strong>(8</strong>), neoastilbin (<strong>9</strong>), astilbin (<strong>10</strong>), quercitrin (<strong>11</strong>), neoschaftoside (<strong>12</strong>), apigenin 6,8-bis-<em>C</em>-<em>α</em>-<em>L</em>-arabinoside (<strong>13</strong>), vitexin (<strong>14</strong>), bergenin (<strong>15</strong>), scopoletin (<strong>16</strong>), glucopyranoside salicyl (<strong>17</strong>), koaburside (<strong>18</strong>), benzyl <em>β</em>-<em>D</em>-glucoside (<strong>19</strong>), icariside B5 (<strong>20</strong>), roseoside (<strong>21</strong>), loliolide (<strong>22</strong>), and adenosine (<strong>23</strong>). The tested compounds did not show LDH inhibition nor antiproliferative activity.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new glycoside. Compounds <strong>2</strong> and <strong>3</strong> were obtained for the first time from natural source. The 22 known compounds constituted of alkaloids (<strong>2</strong>–<strong>4</strong>, <strong>23</strong>), phenolics (<strong>5</strong>, <strong>15</strong>, <strong>17</strong>, <strong>18</strong>), flavonoids (<strong>6</strong>–<strong>14</strong>), coumarin (<strong>16</strong>), benzyl glycoside (<strong>19</strong>), and norsesquiterpenes (<strong>20</strong>–<strong>22</strong>). All the compounds, <strong>1</strong>–<strong>23</strong>, were revealed from <em>M. hemsleyana</em> for the first time. This is the initial uncovering of molecules <strong>1</strong>–<strong>10</strong>, <strong>12</strong>, <strong>13</strong>, <strong>17</strong>–<strong>19</strong>, and <strong>23</strong> from the genus <em>Macaranga</em>. The isolated compounds","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 481-486"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000746/pdfft?md5=fd934d08969499d988ae88f6a2d4dadf&pid=1-s2.0-S1674638423000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44776875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2023.03.005
Minhang Dou , Jiayi Huang , Mimi Yu , Huahua Li , Yang Song , Ziwei Peng , Shouying Du , Jie Bai
Objective
Huamaoyan Granules (HMYG) and Huamaoyan Capsules (HMYC) are Chinese patent medicines with different dosage forms of the same prescription. Due to the different preparation process, the chemical composition of these Chinese patent medicines varies greatly among different forms, but there were few studies on the difference comparison and quality control of them. In order to improve the effectiveness and safety in its clinical application, an idea combining high performance liquid chromatography (HPLC) and chemometrics was put forward to study the quality control of Chinese patent medicines in different dosage forms of the same prescription.
Methods
The differential markers of HMYG and HMYC were explored based on HPLC fingerprint and chemometrics including orthogonal projections to latent structures-discriminant analysis (OPLS-DA), principal component analysis (PCA), and hierarchical cluster analysis (HCA). Finally, the quantitative analysis method of related components was established by HPLC.
Results
A quality control method for HMYG and HMYC was established. Firstly, the chemical components of HMYG and HMYC were systematically analyzed by HPLC fingerprinting. Further exploration showed that there were 20 characteristic peaks and 57 common peaks. Then, the potential differential markers between HMYG and HMYC were explored by chemometrics, and the differential markers were screened after intersection with the 20 characteristic peaks. Finally, HPLC quantitative analysis methods for nine components were established, including seven differential markers (neochlorogenic acid, protocatechualdehyde, chlorogenic acid, cryptochlorogenic acid, caffeic acid, rosmarinic acid and salvianolic acid A). The results of HPLC quantitative analysis showed that the contents of eight components in HMYG and HMYC samples were significantly different. According to the above results, the differential markers between HMYG and HMYC screened based on HPLC fingerprint and chemometrics can effectively characterize the differences between the two dosage forms.
Conclusion
The present work provides a rapid and effective method for routine quality evaluation and control of HMYG and HMYC. This work also provides feasible methods for the quality evaluation and control of Chinese patent medicines with different dosage forms of the same prescription.
{"title":"HPLC combined with chemometrics for quality control of Huamoyan Granules or Capsules","authors":"Minhang Dou , Jiayi Huang , Mimi Yu , Huahua Li , Yang Song , Ziwei Peng , Shouying Du , Jie Bai","doi":"10.1016/j.chmed.2023.03.005","DOIUrl":"10.1016/j.chmed.2023.03.005","url":null,"abstract":"<div><h3>Objective</h3><p>Huamaoyan Granules (HMYG) and Huamaoyan Capsules (HMYC) are Chinese patent medicines with different dosage forms of the same prescription. Due to the different preparation process, the chemical composition of these Chinese patent medicines varies greatly among different forms, but there were few studies on the difference comparison and quality control of them. In order to improve the effectiveness and safety in its clinical application, an idea combining high performance liquid chromatography (HPLC) and chemometrics was put forward to study the quality control of Chinese patent medicines in different dosage forms of the same prescription.</p></div><div><h3>Methods</h3><p>The differential markers of HMYG and HMYC were explored based on HPLC fingerprint and chemometrics including orthogonal projections to latent structures-discriminant analysis (OPLS-DA), principal component analysis (PCA), and hierarchical cluster analysis (HCA). Finally, the quantitative analysis method of related components was established by HPLC.</p></div><div><h3>Results</h3><p>A quality control method for HMYG and HMYC was established. Firstly, the chemical components of HMYG and HMYC were systematically analyzed by HPLC fingerprinting. Further exploration showed that there were 20 characteristic peaks and 57 common peaks. Then, the potential differential markers between HMYG and HMYC were explored by chemometrics, and the differential markers were screened after intersection with the 20 characteristic peaks. Finally, HPLC quantitative analysis methods for nine components were established, including seven differential markers (neochlorogenic acid, protocatechualdehyde, chlorogenic acid, cryptochlorogenic acid, caffeic acid, rosmarinic acid and salvianolic acid A). The results of HPLC quantitative analysis showed that the contents of eight components in HMYG and HMYC samples were significantly different. According to the above results, the differential markers between HMYG and HMYC screened based on HPLC fingerprint and chemometrics can effectively characterize the differences between the two dosage forms.</p></div><div><h3>Conclusion</h3><p>The present work provides a rapid and effective method for routine quality evaluation and control of HMYG and HMYC. This work also provides feasible methods for the quality evaluation and control of Chinese patent medicines with different dosage forms of the same prescription.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 449-456"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000722/pdfft?md5=cdb74b0fbddd8abb2d541fd9031160c6&pid=1-s2.0-S1674638423000722-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41446455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2024.01.006
Ping Wei , Shiying Huang , Juan Yang , Mo Zhao , Qiugu Chen , Xiaoyu Deng , Jianping Chen , Yisheng Li
Objective
Mahuang Guizhi Decoction (MGD), an essential herbal pair in traditional Chinese medicine, is able to release cold, fever and asthma, mainly containing alkaloids, flavonoids, phenylpropanoids and amino acids. However, the absorption and distribution of these four category compounds in vivo still remained unclearly.
Methods
In our research, we utilized UPLC-Q-TOF-MS technique to identify the constituents within MGD, as well as the prototypes of MGD and their metabolites absorbed in plasma and brain. We further profiled the drug-time curve of prototypes and metabolites of MGD both in plasma and brain.
Results
Our results showed that 105 constituents were characterized in MGD. Thirty of them could be absorbed into blood, and ten of them could be distributed into brain. We also discovered eight new bio-transformed metabolites in blood, and a half of which could pass through the blood–brain barrier. In addition, all components detected in vivo could be absorbed and distributed immediately.
Conclusion
These findings provide an approachable method to analyze the potential bio-active compounds in MGD and their in vivo behaviors, which could promote the efficacious material basis study of MGD and the security of clinical utilization.
{"title":"Identification and characterization of chemical constituents in Mahuang Guizhi Decoction and their metabolites in rat plasma and brain by UPLC-Q-TOF/MS","authors":"Ping Wei , Shiying Huang , Juan Yang , Mo Zhao , Qiugu Chen , Xiaoyu Deng , Jianping Chen , Yisheng Li","doi":"10.1016/j.chmed.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.006","url":null,"abstract":"<div><h3>Objective</h3><p>Mahuang Guizhi Decoction (MGD), an essential herbal pair in traditional Chinese medicine, is able to release cold, fever and asthma, mainly containing alkaloids, flavonoids, phenylpropanoids and amino acids. However, the absorption and distribution of these four category compounds <em>in vivo</em> still remained unclearly.</p></div><div><h3>Methods</h3><p>In our research, we utilized UPLC-Q-TOF-MS technique to identify the constituents within MGD, as well as the prototypes of MGD and their metabolites absorbed in plasma and brain. We further profiled the drug-time curve of prototypes and metabolites of MGD both in plasma and brain.</p></div><div><h3>Results</h3><p>Our results showed that 105 constituents were characterized in MGD. Thirty of them could be absorbed into blood, and ten of them could be distributed into brain. We also discovered eight new bio-transformed metabolites in blood, and a half of which could pass through the blood–brain barrier. In addition, all components detected <em>in vivo</em> could be absorbed and distributed immediately.</p></div><div><h3>Conclusion</h3><p>These findings provide an approachable method to analyze the potential bio-active compounds in MGD and their <em>in vivo</em> behaviors, which could promote the efficacious material basis study of MGD and the security of clinical utilization.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 466-480"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000479/pdfft?md5=65c0244ee53b36a8b86b7af6cc5fb975&pid=1-s2.0-S1674638424000479-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2024.01.004
Lin Shi , Tong Cui , Xinyue Wang , Rina Wu , Junrui Wu , Yanqun Wang , Weiming Wang
In Northeast China, Goubao pickle is a popular food fermented from the roots of Platycodon grandiflorum as the main material, offering a unique flavor and rich nutritional value. Platycosides in roots of P. grandiflorum may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation. However, biotransfermation of platycosides has not been reviewed during fermentation. In this study, we reviewed platycosides in chemical diversity, metabolic processes in vivo, biotransformation of platycosides in vitro, and pharmacological effects. Finally, we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.
{"title":"Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots","authors":"Lin Shi , Tong Cui , Xinyue Wang , Rina Wu , Junrui Wu , Yanqun Wang , Weiming Wang","doi":"10.1016/j.chmed.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.004","url":null,"abstract":"<div><p>In Northeast China, Goubao pickle is a popular food fermented from the roots of <em>Platycodon grandiflorum</em> as the main material, offering a unique flavor and rich nutritional value. Platycosides in roots of <em>P. grandiflorum</em> may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation. However, biotransfermation of platycosides has not been reviewed during fermentation. In this study, we reviewed platycosides in chemical diversity, metabolic processes <em>in vivo</em>, biotransformation of platycosides <em>in vitro,</em> and pharmacological effects. Finally, we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 392-400"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000388/pdfft?md5=eb1aa15706a1576af4661e204dcd8a22&pid=1-s2.0-S1674638424000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2023.07.005
Xin Li , Min Wang , Yuhong Zhong , Qianqian Yin , Zheming Hu , Wenli Tian , Zhongyan Liu , Zhidong Liu
Objective
To investigate the plasma pharmacokinetics of six representative components (nodakenin, osthole, 5-O-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin), which were the ingredients of Qianghuo Shengshi Decoction (QSD) granules, in normal and rheumatoid arthritis (RA) rats administrated QSD granules intragastrically.
Methods
A rapid and accurate ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of six components in plasma, and it showed a good specificity, linearity, intra-day and inter-day precision, intra-day and inter-day accuracy, extraction recovery, stability, and the less matrix effect.
Results
The validated LC-MS/MS method was successfully used to compare the plasma pharmacokinetics of six ingredients between normal and RA rats after intragastrical administration of QSD granules and differences in the pharmacokinetics were found in two types of rats. The absorption rate in the RA rats was lower for nodakenin, osthole, 5-O-methylvisammioside, liquiritigenin and liquiritin than in the normal group, while the absorption rate of ferulic acid remained constant in two groups. In comparison with the normal rats, the exposure concentration of nodakenin was higher and that of other five components except for nodakenin was lower under pathological conditions. Additionally, the absorptive amount of nodakenin, osthole, 5-O-methylvisammioside and liquiritin was increased and that of ferulic acid and liquiritigenin was reduced in the RA rats than in the normal rats. Compared with the normal rats, the retention time of nodakenin, ferulic acid and liquiritin was reduced in vivo, whereas the retention time of osthole, 5-O-methylvisammioside and liquiritigenin was raised in the body for the RA rats. In contrast to the normal rats, the data demonstrated an increase in the elimination velocity of nodakenin and a decrease in the elimination velocity of the other five components except for nodakenin in the pathological state.
Conclusion
This study showed that the pharmacokinetic behavior of the six components, nodakenin, osthole, 5-O-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin, is different in vivo between normal and pathological states of rats, and this research provided the necessary experimental data to explain the pharmacokinetics of QSD granules in both normal and pathological states and provide some references for its clinical application at some level.
{"title":"Comparative pharmacokinetics of six components in normal and rheumatoid arthritis rats after intragastrical administration of Qianghuo Shengshi Decoction granules by LC-MS/MS","authors":"Xin Li , Min Wang , Yuhong Zhong , Qianqian Yin , Zheming Hu , Wenli Tian , Zhongyan Liu , Zhidong Liu","doi":"10.1016/j.chmed.2023.07.005","DOIUrl":"10.1016/j.chmed.2023.07.005","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the plasma pharmacokinetics of six representative components (nodakenin, osthole, 5-<em>O</em>-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin), which were the ingredients of Qianghuo Shengshi Decoction (QSD) granules, in normal and rheumatoid arthritis (RA) rats administrated QSD granules intragastrically.</p></div><div><h3>Methods</h3><p>A rapid and accurate ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of six components in plasma, and it showed a good specificity, linearity, intra-day and inter-day precision, intra-day and inter-day accuracy, extraction recovery, stability, and the less matrix effect.</p></div><div><h3>Results</h3><p>The validated LC-MS/MS method was successfully used to compare the plasma pharmacokinetics of six ingredients between normal and RA rats after intragastrical administration of QSD granules and differences in the pharmacokinetics were found in two types of rats. The absorption rate in the RA rats was lower for nodakenin, osthole, 5-<em>O</em>-methylvisammioside, liquiritigenin and liquiritin than in the normal group, while the absorption rate of ferulic acid remained constant in two groups. In<!--> <!-->comparison<!--> <!-->with the normal rats, the exposure concentration of nodakenin was higher and that of other five components except for nodakenin was lower under pathological conditions. Additionally, the absorptive amount of nodakenin, osthole, 5-<em>O</em>-methylvisammioside and liquiritin was increased and that of ferulic acid and liquiritigenin was reduced in the RA rats than in the normal rats. Compared with the normal rats, the retention time of nodakenin, ferulic acid and liquiritin was reduced <em>in vivo</em>, whereas the retention time of osthole, 5-<em>O</em>-methylvisammioside and liquiritigenin was raised in the body for the RA rats. In contrast to the normal rats, the data demonstrated an increase in the elimination velocity of nodakenin and a decrease in the elimination velocity of the other five components except for nodakenin in the pathological state.</p></div><div><h3>Conclusion</h3><p>This study showed that the pharmacokinetic behavior of the six components, nodakenin, osthole, 5-<em>O</em>-methylvisammioside, ferulic acid, liquiritigenin, and liquiritin, is different <em>in vivo</em> between normal and pathological states of rats, and this research provided the necessary experimental data to explain the pharmacokinetics of QSD granules in both normal and pathological states and provide some references for its clinical application at some level.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 457-465"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000145/pdfft?md5=eaf1505a26431ba6e1e0cb6495d30c55&pid=1-s2.0-S1674638424000145-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2024.05.001
Wenyuan Gao
{"title":"Comprehensive summary of material basis − Laying a foundation for substances of medicine food homology development","authors":"Wenyuan Gao","doi":"10.1016/j.chmed.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.05.001","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 311-312"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000509/pdfft?md5=2732d4acbd6b3aeaa19ee4eba0412798&pid=1-s2.0-S1674638424000509-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2023.04.001
Zhiyong Zhang , Xiaoyang Zhang , Xi Wang , Xuting Guo , Xinhao Yan , Zheng Li , Wenlong Li
The genus Hippocampus is a multi-origin animal species with high medicinal and healthcare values. About 57 species of Hippocampus spread worldwide, of which about 14 species can be used as medicine, showing anti-oxidation, anti-inflammation, anti-depressant, anti-hypertension, anti-prostatic hyperplasia, antivirus, anti-apoptotic, antifatigue, and so on. And those pharmacological effects are mainly related to their active ingredients, including amino acids, abundant proteins (peptides and oligopeptides), fatty acids, nucleosides, steroids, and other small molecular compounds. The main means of authentication of Hippocampus species are morphological identification, microscopic identification, thin layer chromatography method, fingerprint method and genomics method. This review will provide useful insight for exploration, further study and precise medication of Hippocampus in the future.
{"title":"Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review","authors":"Zhiyong Zhang , Xiaoyang Zhang , Xi Wang , Xuting Guo , Xinhao Yan , Zheng Li , Wenlong Li","doi":"10.1016/j.chmed.2023.04.001","DOIUrl":"10.1016/j.chmed.2023.04.001","url":null,"abstract":"<div><p>The genus <em>Hippocampus</em> is a multi-origin animal species with high medicinal and healthcare values. About 57 species of <em>Hippocampus</em> spread worldwide, of which about 14 species can be used as medicine, showing anti-oxidation, anti-inflammation, anti-depressant, anti-hypertension, anti-prostatic hyperplasia, antivirus, anti-apoptotic, antifatigue, and so on. And those pharmacological effects are mainly related to their active ingredients, including amino acids, abundant proteins (peptides and oligopeptides), fatty acids, nucleosides, steroids, and other small molecular compounds. The main means of authentication of <em>Hippocampus</em> species are morphological identification, microscopic identification, thin layer chromatography method, fingerprint method and genomics method. This review will provide useful insight for exploration, further study and precise medication of <em>Hippocampus</em> in the future.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 344-357"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000758/pdfft?md5=7d393b3e1d7cb7ad98f133b791592db0&pid=1-s2.0-S1674638423000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46497095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2023.07.002
Xiqin Du , Meng Zhang , Shuping Wang , Jingyang Li , Jingze Zhang , Dailin Liu
Cymbopogon citratus in the gramineous family, also known as lemongrass (LG), is a perennial herb. LG, a drug and food homologous medicine, has a widely recorded medicinal value and food applications. To date, 158 LG compounds have been reported, including terpenoids, flavonoids, phenolic acids. Pharmacological and clinical studies have indicated that LG has antibacterial, neuroprotective, hypoglycemic, hypotensive, anti-inflammatory, and anti-tumor effects. This article reviews LG in ethnopharmacology, chemical composition, pharmacology, food, medicine, and daily chemical applications to provide a basis for the subsequent development of food and medicine.
{"title":"Ethnopharmacology, chemical composition and functions of Cymbopogon citratus","authors":"Xiqin Du , Meng Zhang , Shuping Wang , Jingyang Li , Jingze Zhang , Dailin Liu","doi":"10.1016/j.chmed.2023.07.002","DOIUrl":"10.1016/j.chmed.2023.07.002","url":null,"abstract":"<div><p><em>Cymbopogon citratus</em> in the gramineous family, also known as lemongrass (LG), is a perennial herb. LG, a drug and food homologous medicine, has a widely recorded medicinal value and food applications. To date, 158 LG compounds have been reported, including terpenoids, flavonoids, phenolic acids. Pharmacological and clinical studies have indicated that LG has antibacterial, neuroprotective, hypoglycemic, hypotensive, anti-inflammatory, and anti-tumor effects. This article reviews LG in ethnopharmacology, chemical composition, pharmacology, food, medicine, and daily chemical applications to provide a basis for the subsequent development of food and medicine.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 358-374"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423001028/pdfft?md5=d2d8916343465fcb851d609b65726f5f&pid=1-s2.0-S1674638423001028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.chmed.2023.09.007
Jianying Liu , Binzhi Zhang , Leqi Wang , Shasha Li , Qinqiang Long , Xue Xiao
Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G. lucidum spores (GLS) are tiny germ cells released from the mushroom cap during the mature stage of growth. They contain all the genetic active substances of G. lucidum. G. lucidum spore oil (GLSO) is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO2 extraction technology. GLSO contains fatty acids, Ganoderma triterpenes, sterols and other bioactive compounds. Previous studies have demonstrated that GLSO has a wide range of pharmacological properties, including anti-tumor, anti-aging, neuroprotection, immunomodulation, hepatoprotection and modulation of metabolic diseases. This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components, extraction and processing techniques, pharmacological effects and safety evaluation. This provides a solid foundation for further research and application of GLSO.
{"title":"Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review","authors":"Jianying Liu , Binzhi Zhang , Leqi Wang , Shasha Li , Qinqiang Long , Xue Xiao","doi":"10.1016/j.chmed.2023.09.007","DOIUrl":"10.1016/j.chmed.2023.09.007","url":null,"abstract":"<div><p><em>Ganoderma lucidum</em> is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. <em>G. lucidum</em> spores (GLS) are tiny germ cells released from the mushroom cap during the mature stage of growth. They contain all the genetic active substances of <em>G. lucidum</em>. <em>G. lucidum</em> spore oil (GLSO) is a lipid component extracted from broken-walled <em>Ganoderma</em> spores using supercritical CO<sub>2</sub> extraction technology. GLSO contains fatty acids, <em>Ganoderma</em> triterpenes, sterols and other bioactive compounds. Previous studies have demonstrated that GLSO has a wide range of pharmacological properties, including anti-tumor, anti-aging, neuroprotection, immunomodulation, hepatoprotection and modulation of metabolic diseases. This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components, extraction and processing techniques, pharmacological effects and safety evaluation. This provides a solid foundation for further research and application of GLSO.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 375-391"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000042/pdfft?md5=bffb6cf10a5e0c6d1b55b33bbfaae425&pid=1-s2.0-S1674638424000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号