Chinese Herbal Medicines最新文献

{"title":"Sini Decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism","authors":"Cuiping Long, Qian Zhou, Min Xu, Xin Ding, Xingxing Zhang, Ya Zhang, Yuping Tang, Guangguo Tan","doi":"10.1016/j.chmed.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.12.004","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics combined with network pharmacology reveals anti-asthmatic effects of Nepeta bracteata on allergic asthma rats","authors":"Kailibinuer Abulaiti, Miheleayi Aikepa, Mireguli Ainaidu, Jiaxin Wang, Maiwulanijiang Yizibula, Maihesumu Aikemu","doi":"10.1016/j.chmed.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.02.001","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of Shufeng Jiedu Capsule in treating bacterial pneumonia based on network pharmacology and experimental verification","authors":"Yingli Xu Data analysis, Lei Bao, Ronghua Zhao, Zi-han Geng, Shurang Li, Bo Pang, Qiyue Sun, Shanshan Guo, Xiaolan Cui, Jing Sun","doi":"10.1016/j.chmed.2024.01.002","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.002","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound Danshen Dripping Pills combined with isosorbide mononitrate for angina pectoris: A systematic review and a Meta-analysis","authors":"Ru Wang, Jing Hu, Yuanyuan Li, Hong Yin","doi":"10.1016/j.chmed.2023.12.005","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.12.005","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui Granules","authors":"Qi Wang, Yingxia Zhao, Xuemei Qin, Junsheng Tian","doi":"10.1016/j.chmed.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.chmed.2023.12.003","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140470021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways","authors":"Yuanyuan Chen ,&nbsp;Shanshan Chen ,&nbsp;Kaiting Chen ,&nbsp;Lanfang Ji ,&nbsp;Shuna Cui","doi":"10.1016/j.chmed.2023.01.004","DOIUrl":"10.1016/j.chmed.2023.01.004","url":null,"abstract":"<div><h3>Objective</h3><p>This study is designed to investigate the mode of action of the synergistic effect of 5-fluorouracil (5-FU) and magnolol against cervical cancer.</p></div><div><h3>Methods</h3><p>Network pharmacological approach was applied to predict the molecular mechanism of 5-FU combined with magnolol against cervical cancer. CCK-8 assay, colony formation assay, immunofluorescence staining, adhesion assay, wound healing mobility assay, cell migration and invasion assay and Western blot analysis were conducted to validate the results of <em>in silico</em> study.</p></div><div><h3>Results</h3><p>Phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway was identified as the key pathway <em>in silico</em> study. The experimental results showed that 5-FU combined with magnolol strongly inhibited cervical cancer cell proliferation, induced the morphological change of HeLa cells by down-regulating the expression of <em>α</em>-actinin, tensin-2 and vinculin. Moreover, magnolol enhanced inhibitory effect of 5-FU on the cell adhesion, migration and invasion. The phosphorylation of AKT and PI3K and the expression of mTOR were strongly inhibited by the combination of 5-FU and magnolol. Moreover, the expression of E-cadherin and <em>β</em>-catenin was upregulated and the expression of Snail, Slug and vimentin was down-regulated by the 5-FU together with magnolol.</p></div><div><h3>Conclusion</h3><p>Taken together, this study suggests that 5-FU combined with magnolol exerts a synergistic anti-cervical cancer effect by regulating the PI3K/AKT/mTOR and epithelial-mesenchymal transition (EMT) signaling pathways.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000540/pdfft?md5=fb223695f3b17d7b14f4aff34742d7b6&pid=1-s2.0-S1674638423000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43979249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of natural products from medicinal plants: Challenges, progress and prospects","authors":"Shilin Chen (Associate Editor-in-Chief)","doi":"10.1016/j.chmed.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.01.001","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000029/pdfft?md5=ce46f7400b6d872f3560075c67d14c47&pid=1-s2.0-S1674638424000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139714515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection","authors":"Xiajing Xu ,&nbsp;Yongli Guo ,&nbsp;Menglin Chen ,&nbsp;Ning Li ,&nbsp;Yi Sun ,&nbsp;Shumeng Ren ,&nbsp;Jiao Xiao ,&nbsp;Dongmei Wang ,&nbsp;Xiaoqiu Liu ,&nbsp;Yingni Pan","doi":"10.1016/j.chmed.2022.11.009","DOIUrl":"10.1016/j.chmed.2022.11.009","url":null,"abstract":"<div><h3>Objective</h3><p>To identify phytochemical constituents present in the extract of flowers of <em>Xanthoceras sorbifolia</em> and evaluate their anti-oxidant and anti-hyperglycemic capacities.</p></div><div><h3>Methods</h3><p>The AlCl₃ colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti − oxidative activity <em>in vitro</em>. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C₁₈ column (2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase (PDB ID: 2CDU) by molecular docking.</p></div><div><h3>Results</h3><p>Combined with the results of activity screening <em>in vitro</em>, the anti − oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatography-mass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. <em>In vivo</em> experiments showed that flowers of <em>X. sorbifolia</em> could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-<em>O</em>-rutinoside, kaempferol-3-<em>O</em>-rhamnoside, isorhamnetin-3-<em>O</em>-glucoside, and isoquercitrin showed a better inhibitory profile.</p></div><div><h3>Conclusion</h3><p>The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested <em>X. sorbifolia</em> flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000576/pdfft?md5=db1a4cca68dc49c6336fbceb4c875315&pid=1-s2.0-S1674638423000576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43642885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis","authors":"Zhonghua Dong ,&nbsp;Xiao Sun","doi":"10.1016/j.chmed.2022.11.008","DOIUrl":"10.1016/j.chmed.2022.11.008","url":null,"abstract":"<div><h3>Objective</h3><p>Cultivated <em>Cordyceps sinensis</em> powder has been used as clinical drug and healthy food to nourish the lung and kidney, which solves the problem of serious shortage of wild <em>C. sinensis</em>. This study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated <em>C. sinensis</em>.</p></div><div><h3>Methods</h3><p>Nucleosides, sterols and polysaccharides were separated and purified from cultivated <em>C. sinensis</em>, and analyzed by high performance liquid chromatography, gas chromatography-mass spectrometry and chemical chromogenic methods, respectively. In high glucose-induced rat mesangial cell models, fibronectin and type 1 collagen were used as evaluation indicators.</p></div><div><h3>Results</h3><p>There were 10 kinds of nucleosides and one sterol in cultivated <em>C. sinensis</em>. The contents of nucleosides, sterols and polysaccharides in the cultivated <em>C. sinensis</em> were close to 2%, 0.55% and 4.4%, respectively. Furthermore, nucleoside, sterol and polysaccharide components exhibited varying degrees of anti-fibrotic activity. The nucleoside components and sterol components inhibited the expression of extracellular matrix more effectively in the three main components.</p></div><div><h3>Conclusion</h3><p>Cultivated <em>C. sinensis</em> remains the similar compounds with the wild <em>C. sinensis</em>, and nucleosides and sterols may be the main active substances that contribute to its anti-fibrotic effects. The project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated <em>C. sinensis</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000552/pdfft?md5=319177d3f4deaee59ed069f7d56fc30b&pid=1-s2.0-S1674638423000552-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41960117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Rhei Radix et Rhizoma and Eupolyphaga Steleophaga on liver protection mechanism based on pharmacokinetics and metabonomics","authors":"Gang Feng ,&nbsp;Jianli Bi ,&nbsp;Wenfang Jin ,&nbsp;Qi Wang ,&nbsp;Zhaokui Dan ,&nbsp;Baolei Fan","doi":"10.1016/j.chmed.2023.10.002","DOIUrl":"10.1016/j.chmed.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p>Based on metabonomics technology of high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) and hydrogen nuclear magnetic resonance spectroscopy (¹H NMR), the pharmacokinetic characteristics and therapeutic mechanism of <em>Rhei Radix</em> et <em>Rhizoma</em> (RhRR, Dahuang in Chinese), <em>Eupolyphaga Steleophaga</em> (EuS, Tubiechong in Chinese) combined with RhRR acting on acute liver injury were explored.</p></div><div><h3>Methods</h3><p>Models of acute liver injury were established, and the pharmacokinetic methods of five components of RhRR-EuS in rats were found by HPLC-MS/MS. The liver tissues of different groups of mice were analyzed by ¹H NMR spectroscopy combined with multivariate statistical analysis to investigate the metabolomics of RhRR-EuS and RhRR.</p></div><div><h3>Results</h3><p>Pharmacokinetic results showed there were different levels of bimodal phenomenon in different groups, and the absorption of free anthraquinone in RhRR increased after compatibility with EuS. In addition, the pathological state of acute liver injury in rats can selectively promote the absorption of emodin, chrysophanol, physcion and aloe emodin. Through 15 differential metabolites in the liver tissue of acute liver injury mice, it was revealed that RhRR-EuS and RhRR could protect the liver injury by regulating the metabolism of glutamine and glutamic acid, alanine, aspartic acid and glutamic acid, and phosphoinositide. However, the regulation of RhRR was weaker than that of RhRR-EuS.</p></div><div><h3>Conclusion</h3><p>For the first time, we studied the pharmacokinetics and metabolomics differences of RhRR-EuS and RhRR in rats and mice with acute liver injury, in order to provide theoretical reference for clinical treatment of liver disease by DHZCP.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423001119/pdfft?md5=1debdb34e58fa20485efdba09b369365&pid=1-s2.0-S1674638423001119-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}