Archives of Gerontology and Geriatrics Plus最新文献_第2页

A review on Centella asiatica (L.) nutrient and phytochemical composition and its potential neuroprotective effect in Alzheimer’s disease 积雪草营养成分、植物化学成分及其对阿尔茨海默病潜在神经保护作用的研究进展

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-10 DOI: 10.1016/j.aggp.2025.100237

Vinoth Kumar Ganesan , Rallapalli Rajyalakshmi , Kumaraswamy Dabburu , Dharani Abirama Sundari Shanmugam , Ashwini Devi Balaraman

Background

Alzheimer's disease (AD) is a gradually developing neurodegenerative disease that affects 47 million individuals globally and is the leading cause of mortality. The disease's pathophysiology is complicated, and several hypotheses have been proposed to explain it, including the amyloid cascade hypothesis, tau hypothesis, cholinergic hypothesis, and oxidative stress hypothesis, all of which involve various biochemical processes. Centella asiatica (L.) has been used as a medicinal herb for thousands of years in India, China, Sri Lanka, Nepal, and Madagascar. Centella asiatica (L.) is one of the chief herbs for treating skin problems, to heal wounds, for revitalising the nerves and brain cells, hence primarily known as a "Brain Tonic" in India.

Methods

Using the internet databases Science Direct, Web of Science, Scopus, PubMed, and Google Scholar, the neuroprotective effect of Centella asiatica (L.) was searched. The literature review revealed that Centella asiatica (L.) has been shown to exert broad neuroprotective effects through various mechanisms, including enzyme inhibition, preventing the development of amyloid plaques in AD, reducing dopamine neurotoxicity in Parkinson's disease (PD), and reducing oxidative stress.

Result

It is possible to argue that Centella asiatica (L.) is a sought after phytopharmaceutical with neuroprotective effects, derived from traditional medicine.

Conclusion

Centella asiatica (L.) is a widely consumed green vegetable in many countries; incorporating it as a functional food into a regular diet is a practical approach to reap its many health advantages and nutritional profile. Taking advantage of this plant's medicinal, nutraceutical, and nutritional properties would be a significant contribution to holistic healthy ageing.

阿尔茨海默病（AD）是一种逐渐发展的神经退行性疾病，影响全球4700万人，是导致死亡的主要原因。该疾病的病理生理非常复杂，目前已经提出了几种假说来解释它，包括淀粉样蛋白级联假说、tau假说、胆碱能假说和氧化应激假说，这些假说都涉及多种生化过程。积雪草（Centella asiatica， L.）在印度、中国、斯里兰卡、尼泊尔和马达加斯加被用作草药已有数千年的历史。积雪草（L.）是治疗皮肤问题、愈合伤口、恢复神经和脑细胞活力的主要草药之一，因此在印度主要被称为“脑补品”。方法利用Science Direct、Web of Science、Scopus、PubMed、谷歌Scholar等网络数据库，对积雪草的神经保护作用进行检索。文献综述显示积雪草（Centella asiatica， L.）已被证明通过多种机制发挥广泛的神经保护作用，包括酶抑制，防止AD中淀粉样斑块的形成，降低帕金森病（PD）中的多巴胺神经毒性，以及降低氧化应激。结果积雪草（Centella asiatica， L.）是一种从传统医学中衍生出来的具有神经保护作用的植物药。结论积雪草（centella asiatica， L.）是许多国家广泛食用的绿色蔬菜；将它作为一种功能性食品纳入日常饮食是一种实用的方法，可以获得它的许多健康优势和营养成分。利用这种植物的药用、营养和营养特性将对整体健康老龄化做出重大贡献。

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引用次数: 0

Rethinking family care: How changing family dynamics are reshaping support for older adults in india? 重新思考家庭护理：如何改变家庭动态正在重塑对印度老年人的支持？

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-08 DOI: 10.1016/j.aggp.2025.100236

Raghunath Mandi, Dhananjay W Bansod PhD, Amit Kumar Goyal

India experienced considerable changes in social structure and family institutions, which have tremendous implications on the caregiving structure for older adults, especially for those who, due to physical disability, are unable to care for themselves. As India navigates the complexities of an aging population, rethinking family care is crucial to ensuring the well-being and dignity of older adults. Using data from the Longitudinal Ageing Study in India (LASI), this study examined the pattern of family care provisions, with specific to the role of living arrangements, the impact of spousal presence, and children’s proximity on caregiving choices using logistic regression. Findings highlighted only one-fourth of older adults receive care from families. Spouses continued to play a major role in caregiving, even if they were co-residing with children. The presence of extended family members & proximity to children reduces the complete dependence on children for care. Family dynamics in care provision are shaped by various interconnected factors. These factors influence the type, intensity, and emotional appearance of caregiving. Understanding these dynamics is crucial for families and policymakers in addressing the challenges and ensuring that older adults receive the care and support they need.

印度在社会结构和家庭制度方面经历了相当大的变化，这对老年人的照顾结构，特别是对那些由于身体残疾而无法照顾自己的老年人，产生了巨大的影响。随着印度应对人口老龄化的复杂性，重新思考家庭护理对确保老年人的福祉和尊严至关重要。利用印度纵向老龄化研究（LASI）的数据，本研究使用逻辑回归分析了家庭护理提供的模式，特别是生活安排的作用、配偶的存在和子女的接近性对护理选择的影响。调查结果显示，只有四分之一的老年人得到家人的照顾。配偶继续在照顾孩子方面发挥主要作用，即使他们和孩子住在一起。大家庭成员的存在与孩子的亲近减少了对孩子的完全依赖。提供护理的家庭动态受到各种相互关联的因素的影响。这些因素影响照顾的类型、强度和情绪表现。了解这些动态对于家庭和政策制定者应对挑战并确保老年人获得所需的护理和支持至关重要。

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引用次数: 0

Coexisting morbidities among older adults with hypertension in India: Prevalence and risk analysis 印度老年高血压患者的共存疾病：患病率和风险分析

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 DOI: 10.1016/j.aggp.2025.100226

Madhusmita Tipiria M.A. , Ujjwal Das Ph.D.

Background

Hypertension is one of the major causes of premature death and one of the leading risk factors for multi-morbidity. Multi-morbidity with hypertension is more prevalent in older adults as compare to younger people. This study aims to assess the prevalence and risk factors of multi-morbidity among older adults with hypertension in India.

Methods

The study using the data from the Longitudinal Ageing Study in India (LASI) conducted in 2017-18. Multi-nominal regression models were used to examine the association between multi-morbidity and various socio-demographic factors among older adults with hypertension. Additionally, Structural Equation Model was employed to identify the direct effects of exogeneous factors on Multi-morbidity with Hypertension.

Results

The finding represents that the risk of multi-morbidity with hypertension is higher at the age of 75 and above (RRR= 8.23) as compared to young age people. The prevalence of multi-morbidity with hypertension increases with age, economic status, education. Gender difference indicates that females had 39 % lower risk of multimorbidity than males. SEM result shows that among all the exogenous factor age, social group, education and MPCE of the respondent showed the highest direct effect on multi-morbidity with hypertension. The prevalence of multi-morbidity with Hypertension is higher in the state Punjab (41.92 %) and followed by Jammu & Kashmir, and the lower prevalence of multi-morbidity with Hypertension in the state Nagaland (12.57 %).

Conclusion

This research provides valuable insights into the healthcare needs of older adults with hypertension and inform policy interventions for better management of chronic diseases in aging populations.

背景高血压是导致过早死亡的主要原因之一，也是多种疾病的主要危险因素之一。与年轻人相比，高血压多病在老年人中更为普遍。本研究旨在评估印度老年高血压患者多发病的患病率和危险因素。方法本研究使用了2017-18年印度纵向老龄化研究（LASI）的数据。多标称回归模型用于检验老年高血压患者多发病与各种社会人口因素之间的关系。此外，采用结构方程模型确定外源性因素对高血压多发病的直接影响。结果75岁及以上人群高血压多病风险高于年轻人群（RRR= 8.23）。高血压多病患病率随年龄、经济状况、教育程度的增加而增加。性别差异表明，女性多病风险比男性低39%。SEM结果显示，在所有外生因素中，年龄、社会群体、受教育程度和MPCE对高血压多重发病的直接影响最大。旁遮普多病高血压患病率最高（41.92%），其次是查谟和克什米尔，那加兰邦多病高血压患病率较低（12.57%）。结论本研究为老年高血压患者的医疗保健需求提供了有价值的见解，并为更好地管理老年人慢性病提供了政策干预。

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引用次数: 0

The AWGS 2025 update: From sarcopenia diagnosis to life-course muscle health promotion AWGS 2025更新：从肌肉减少症诊断到终生肌肉健康促进

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 DOI: 10.1016/j.aggp.2025.100227

Liang-Kung Chen MD, PhD

引用次数: 0

Auditory-cognitive markers of mild cognitive impairment: Evidence from a systematic review 轻度认知障碍的听觉认知标志：来自系统评价的证据

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 DOI: 10.1016/j.aggp.2025.100231

Neelesh Benet, Vijay Kumar, Srikar Vijayasarthy

Introduction

Mild Cognitive Impairment (MCI) represents an intermediate stage between normal aging and dementia. Emerging evidence suggests that central auditory processing (CAP) deficits may appear even earlier and serve as sensitive indicators of cognitive decline.

Objective

The literature was reviewed to examine the CAP abilities in individuals with MCI. It also examines existing MCI diagnostic guidelines from various countries to assess how CAP assessments are currently integrated in clinical protocols.

Method

A systematic literature search was conducted using PubMed/Medline, Cochrane Library, Scopus and Google Scholar (Jan 2014–Dec 2024). Key search terms included “temporal resolution,” “dichotic,” “speech-in-noise,” “auditory working memory,” “central auditory processing disorder,” “auditory scene analysis,” “temporal gap detection,” “auditory discrimination,” and “mild cognitive impairment.” Only those studies were shortlisted if they investigated CAP in elderly individuals with MCI. Articles outlining MCI diagnostic guidelines were also considered.

Result

Twenty-nine articles met the inclusion criteria. Twenty-three indicated a significant CAP deficit in persons with MCI. Studies consistently show MCI is associated with CAP impairments. Tests like Gap Detection Threshold, Dichotic Digit Test, Sentence-in-Noise, and Digits Backward effectively distinguish MCI patients from healthy controls. Six articles focused on diagnostic guidelines from various countries. Despite many studies showing CAP deficits in MCI, leading diagnostic guidelines do not include CAP tests.

Conclusion

CAP tests hold promise for the early detection of MCI. Integrating them into clinical guidelines can improve diagnostic sensitivity which may delay its progression to Alzheimer’s disease. Despite their diagnostic utility, such tests are not included in the MCI diagnostic frameworks.

轻度认知障碍（MCI）是介于正常衰老和痴呆之间的中间阶段。新出现的证据表明，中枢听觉处理（CAP）缺陷可能出现得更早，并作为认知能力下降的敏感指标。目的回顾相关文献，探讨MCI患者的CAP能力。它还审查了各国现有的MCI诊断指南，以评估目前如何将CAP评估纳入临床方案。方法系统检索PubMed/Medline、Cochrane Library、Scopus和谷歌Scholar（2014年1月- 2024年12月）的文献。关键搜索词包括“时间分辨”、“二分法”、“噪音中的言语”、“听觉工作记忆”、“中央听觉处理障碍”、“听觉场景分析”、“时间间隙检测”、“听觉辨别”和“轻度认知障碍”。只有那些调查老年轻度认知障碍患者CAP的研究被列入候选名单。还考虑了概述MCI诊断指南的文章。结果29篇文章符合纳入标准。23例轻度认知障碍患者CAP显著缺失。研究一致表明，轻度认知障碍与CAP损伤有关。间隙检测阈值、二分数字测试、噪声句子、数字倒向等测试可以有效区分轻度认知障碍患者和健康对照组。六篇文章重点介绍了各国的诊断指南。尽管许多研究表明轻度认知损伤存在CAP缺陷，但主流诊断指南并未包括CAP测试。结论cap检测对早期发现轻度认知损伤具有重要意义。将它们纳入临床指南可以提高诊断敏感性，从而可能延缓其向阿尔茨海默病的发展。尽管这些测试具有诊断功能，但它们并未包括在MCI诊断框架中。

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引用次数: 0

Corrigendum to “Restrictions in community-based care services and the effect on family caregivers during the COVID-19 pandemic: A mixed-methods study” [Archives of Gerontology and Geriatrics Plus, Volume 2, Issue 4 (2025), Article 100205] “COVID-19大流行期间社区护理服务的限制及其对家庭照顾者的影响：一项混合方法研究”的勘误表[老年病学档案+，第2卷，第4期（2025），第100205条]

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 DOI: 10.1016/j.aggp.2025.100210

Ayumi Honda , Yin Liu , Mayo Ono , Takahiro Nishida , Tatsuya Tsukigi , Elizabeth B. Fauth , Sumihisa Honda

引用次数: 0

Risk factors for older people utilizing care services in the long-term care insurance system 老年人利用长期护理保险系统中的护理服务的风险因素

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-11-30 DOI: 10.1016/j.aggp.2025.100235

Takahiro Nishida , Ayumi Honda , Kenichiro Fukuda , Yoshihiko Ide , Sumihisa Honda

Background

Preventing the deterioration of health of older adults who need preventive care services from the “support level” to the “care level” in the long-term care insurance (LTCI) system in Japan is an important issue. This study aimed to explore the risk factors related to the deterioration of health among service users at the support level of LTCI.

Methods

The participants were 200 Japanese community-dwelling older adults aged ≥ 65 years who were newly certificated as “support level” and used preventive care services. The users’ physical and cognitive conditions were assessed based on the primary doctor’s opinion and the Kihon checklist. The outcome event was defined as certification at care level 1 or higher. Cox models were used to assess the risk of health deterioration, with adjustments for age, sex, family composition, body mass index, frailty, stroke, dementia status, baseline support level, and social participation in community support projects in the LTCI system.

Results

The 5-year support level maintenance rate was 49.1 %. Male gender (hazard ratio [HR] = 1.7), support level 2 (HR = 2.1), and dementia (HR = 2.1) were identified as factors associated with an adverse outcome, whereas social participation was identified as a preventive outcome (HR = 0.4).

Conclusions

Male gender, support level 2, and dementia were associated with health deterioration among users from the support level to the care level in the LTCI system in Japan. On the other hand, social participation in community support projects may delay deterioration of health.

背景在日本长期护理保险（LTCI）制度中，预防需要预防性护理服务的老年人从“支持级”到“护理级”的健康恶化是一个重要问题。本研究旨在探讨服务使用者健康恶化的相关风险因素。方法研究对象为200名新近被认定为“支持级”并使用预防保健服务的≥65岁的日本社区老年人。根据主治医生的意见和Kihon检查表对使用者的身体和认知状况进行评估。结果事件被定义为1级或更高护理级别的认证。采用Cox模型评估健康恶化的风险，并对LTCI系统中年龄、性别、家庭组成、体重指数、虚弱、中风、痴呆状态、基线支持水平和社区支持项目的社会参与进行调整。结果5年支持水平维持率为49.1%。男性性别（风险比[HR] = 1.7）、支持水平2 （HR = 2.1）和痴呆（HR = 2.1）被确定为与不良结果相关的因素，而社会参与被确定为预防结果（HR = 0.4）。结论在日本LTCI系统中，从支持级到护理级的使用者中，性别偏小、支持等级2和痴呆与健康恶化相关。另一方面，社会参与社区支助项目可以延缓健康的恶化。

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引用次数: 0

Brain health and inflammation in older adults: Preventive care insights from the association between high-sensitivity CRP and hippocampal volume 老年人的大脑健康和炎症：从高敏CRP和海马体积之间的关系中了解预防保健

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-11-26 DOI: 10.1016/j.aggp.2025.100233

Ryuzo Orihashi , Narumi Fujino , Yoshito Mizoguchi

Background

This study aimed to investigate the association between serum high-sensitivity C-reactive protein (hs-CRP) levels, cognitive function, and brain structure in community-dwelling older adults aged 65 years and older. Given the role of inflammation in neurodegeneration, we hypothesized that higher hs-CRP levels would be associated with hippocampal volume and cognitive performance.

Methods

This cross-sectional study included 93 participants (25 men, 68 women) from Kurokawa-cho, Japan. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Clinical Dementia Rating (CDR). Serum hs-CRP levels were measured using an enzyme-linked immunosorbent assay. Brain structural analysis was conducted using voxel-based morphometry (VBM) on MRI scans. Multiple regression analyses were performed, adjusting for age, sex, years of education, and total intracranial volume.

Results

Serum hs-CRP levels were not significantly associated with cognitive function scores. However, VBM analysis revealed a significant negative association between hs-CRP levels and brain volume in the region including the right hippocampus (P < 0.05, corrected for multiple comparisons using family-wise error and false discovery rate corrections). A similar negative association was observed in the region including the left hippocampus, though it did not reach statistical significance.

Conclusions

These findings suggest that systemic inflammation, as indicated by hs-CRP levels, may be linked to smaller hippocampal volume in older adults, independent of cognitive function. This potential association highlights the role of inflammation in brain aging and underscores the importance of preventive healthcare strategies aimed at mitigating inflammation-related neurodegeneration.

本研究旨在探讨65岁及以上社区老年人血清高敏c反应蛋白（hs-CRP）水平、认知功能和脑结构之间的关系。考虑到炎症在神经退行性变中的作用，我们假设较高的hs-CRP水平与海马体积和认知能力有关。方法本横断面研究包括来自日本黑川町的93名参与者（25名男性，68名女性）。认知功能评估采用迷你精神状态检查（MMSE）、额叶评估组（FAB）和临床痴呆评分（CDR）。采用酶联免疫吸附法测定血清hs-CRP水平。脑结构分析采用基于体素形态学（VBM）的MRI扫描。进行多元回归分析，调整年龄、性别、受教育年限和颅内总容积。结果血清hs-CRP水平与认知功能评分无显著相关性。然而，VBM分析显示，hs-CRP水平与包括右海马体在内的该区域的脑容量之间存在显著的负相关（P < 0.05，使用家庭误差和错误发现率校正进行多次比较校正）。在包括左海马体在内的区域也观察到类似的负相关，尽管没有达到统计学意义。结论：这些发现表明，hs-CRP水平所显示的全身性炎症可能与老年人海马体积较小有关，而与认知功能无关。这种潜在的关联强调了炎症在脑衰老中的作用，并强调了旨在减轻炎症相关神经变性的预防性保健策略的重要性。

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引用次数: 0

Association between locomotive syndrome and pre-frailty in community-dwelling older adults: A cross-sectional study 在社区居住的老年人中，运动综合征与前期虚弱之间的关系：一项横断面研究

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-11-17 DOI: 10.1016/j.aggp.2025.100230

Junji Nishimoto , Kazuaki Hamada , Naoki Deguchi , Ryo Tanaka

Background

In super-aged societies, preventing frailty is a key public health priority to ensure longer, healthier lives. Locomotive syndrome (LS), defined as impaired mobility because of musculoskeletal dysfunction, is a modifiable risk factor for frailty. However, the association between LS severity and pre-frailty has not yet been fully elucidated. This study sought to clarify whether the degree of LS is related to pre-frailty among community-dwelling older adults.

Methods

This cross-sectional analysis included data from the DETECt-L cohort (2021–2024). The severity of LS was evaluated in adults aged 65 years and older using three measures: the two-step test, the stand-up test, and the 25-item Geriatric Locomotive Function Scale. Pre-frailty was assessed using the Japanese adaptation of the Cardiovascular Health Study criteria. The association between LS severity and pre-frailty was analyzed using binary logistic regression, with adjustments for age, sex, body mass index, back and knee pain, and history of falls.

Results

Among 512 participants, the prevalence of pre-frailty increased with LS severity. Compared with participants in the non-LS, the proportion of pre-frailty was higher in LS stage 2 (OR: 2.184, 95% CI: 1.094–4.358, P = 0.027), and the same was true for LS stage 3 (OR: 2.254, 95% CI: 1.032–4.922, P = 0.041).

Conclusions

In independently living older adults, LS stage 2 or higher was significantly associated with pre-frailty. Preventing the transition from stage 1 to stage 2 may help reduce pre-frailty risk and support healthy aging. Early orthopedic management of LS could serve as a strategic approach to mitigate frailty in super-aged societies.

在超老龄化社会，预防虚弱是确保更长寿、更健康生活的一项关键公共卫生优先事项。机车综合征（LS），被定义为由于肌肉骨骼功能障碍而导致的活动能力受损，是一种可改变的脆弱危险因素。然而，LS严重程度与前期虚弱之间的关系尚未完全阐明。本研究旨在澄清在社区居住的老年人中，LS的程度是否与前期虚弱有关。方法本横断面分析包括来自DETECt-L队列（2021-2024）的数据。采用两步测试、站立测试和25项老年机车功能量表对65岁及以上成人的LS严重程度进行评估。采用日本心血管健康研究标准对虚弱前期进行评估。使用二元logistic回归分析LS严重程度与前期虚弱之间的关系，并调整年龄、性别、体重指数、背部和膝盖疼痛以及跌倒史。结果在512名参与者中，随着LS严重程度的增加，虚弱前期的患病率增加。与非LS的参与者相比，LS第2期的预衰弱比例更高（OR: 2.184, 95% CI: 1.094-4.358, P = 0.027）， LS第3期也是如此（OR: 2.254, 95% CI: 1.032-4.922, P = 0.041）。结论在独立生活的老年人中，LS 2期及以上与虚弱前期显著相关。防止从第一阶段过渡到第二阶段可能有助于减少脆弱前风险，并支持健康老龄化。LS的早期矫形管理可以作为一种战略方法来减轻超高龄社会的脆弱性。

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引用次数: 0

Sleep timing worsening with age? Visit outdoor-light daily: A cross-sectional study of homemakers and office-going women 睡眠时间随着年龄的增长而恶化？每日造访户外光线：一项针对家庭主妇和上班族女性的横断面研究

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-11-17 DOI: 10.1016/j.aggp.2025.100232

Neelu Jain Gupta , Priyanka Grover , Nisha Singh

The present study depicts differences in sleep behavior, activity, and light exposure of homemakers and office-going women of urban India using a questionnaire survey, actigraphy, and urinary melatonin assay. Self-reported surveys filled by 1316 office-going and 1393 homemaker women (ages 18–79 years) comprised 7 brief questions, viz. body mass index (BMI), work-hours, sleep characteristics etc. We predicted that differences in sleep timings and daily activity patterns of urban Indian women were related to occupational routines, specifically among office-going and homemaker women. Results suggested associativity and relative risk for altered sleep length and recreation with age and occupation. Sleep onset in young and old office-going women was delayed, not in the middle-aged. Objective measurement of sleep, daily activity, and light exposure suggested disrupted Sunday activity than weekdays. Externally managed work-rest cycles in office-goers during weekdays consolidated daily activity patterns. During weekdays, homemakers exhibited greater intraday activity variability. Photometric luminance data using actigraphy revealed homemakers experienced greater exposure to brighter morning light intensities compared to office-going women, although urinary melatonin levels did not differ among groups. The variation in associativity of light-activity during weekdays depicted better light-activity coupling in homemakers. Our observation of delayed sleep onset, in office-goers needs attention because it is an established risk factor to various lifestyle disorders.. Using multimodal methodology of subjective and objective measures, our study validates age-related sleep onset timing, a hidden factor in contemporary health issues.

本研究通过问卷调查、活动记录仪和尿液褪黑素测定，描述了印度城市家庭主妇和上班族女性在睡眠行为、活动和光照方面的差异。由1316名上班族和1393名家庭主妇（年龄在18-79岁）填写的自我报告调查包括7个简短的问题，即身体质量指数（BMI）、工作时间、睡眠特征等。我们预测，印度城市女性的睡眠时间和日常活动模式的差异与职业惯例有关，特别是在办公室和家庭主妇中。结果表明，睡眠时间和娱乐活动的改变与年龄和职业有关。年轻和年老的办公室女性的睡眠开始延迟，而中年女性则没有。对睡眠、日常活动和光照的客观测量表明，周日的活动比平日中断。外部管理的工作日办公人员的工作-休息周期巩固了日常活动模式。在工作日，家庭主妇表现出更大的日内活动变异性。使用活动记录仪的光度数据显示，与上班的女性相比，家庭主妇接触到更明亮的晨光强度，尽管尿中褪黑激素水平在各组之间没有差异。工作日轻活动关联性的变化说明家庭主妇的轻活动耦合性更好。我们在办公室工作人员中观察到的睡眠延迟需要引起注意，因为它是各种生活方式失调的一个确定的风险因素。使用主观和客观测量的多模态方法，我们的研究验证了与年龄相关的睡眠开始时间，这是当代健康问题的一个隐藏因素。

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引用次数: 0