Pub Date : 2025-07-02DOI: 10.1016/j.aggp.2025.100186
Thomas Fraccalini MD , Isa Rita Bergoglio MD, PhD , Gianfranco Fonte MD, PhD , Andrea Trogolo MD , Alessandro Maraschi MD , Thomas Roberts , Beatrice Tarozzo PsyD , Beatriz Vitorino MS , Julia Michelin Vecchini MS , Santoro Mariangela MD , Monica Traversa MD, PhD , Teresa Crea MD , Luciano Cardinale MD, PhD , Giuseppe Maina MD , Valerio Ricci MD, PhD , Elisa Binello CNO , Reald Turja NU , Federico Mallamaci NU , Giovanni Volpicelli MD
Introduction
Delirium, an acute confusional state, is common in elderly hospitalized COVID-19 patients and is linked to poor outcomes. Despite this, underdiagnosis persists due to symptom overlap with dementia. This study investigates whether lung ultrasound (LUS) and cognitive screening can predict delirium risk in elderly COVID-19 patients.
Methods
A prospective study at San Luigi Hospital enrolled 64 COVID-19 patients (mean age 82.6). Pulmonary involvement was assessed using the LUS Extension Score (LUSext), while cognition was evaluated via MMSE and 4AT tests. Clinical data, including comorbidities and inflammatory markers, were analyzed. ROC curves and multivariate regression identified delirium predictors.
Results
Delirium occurred in 61.4 % (35/57). Univariate analysis linked delirium to pre-existing dementia (p = 0.03), higher LUS scores (p = 0.004), and lower MMSE scores (p = 0.0002). A LUS score >3 (sensitivity 74 %, specificity 82 %) best predicted delirium. Multivariate analysis confirmed LUS >3 (OR=4.22, p = 0.023) and lower MMSE (OR=0.87, p = 0.007) as independent risk factors.
Discussion
LUS and cognitive impairment are strong predictors of delirium in elderly COVID-19 patients. The LUSext score provides an objective, rapid bedside measure of lung pathology severity, with a score >3 indicating significantly elevated delirium risk. The link between low MMSE and delirium underscores cognitive vulnerability.
Conclusion
While delirium is multifactorial, integrating LUS into routine assessment may improve early detection and management in resource-limited settings, effectively identifying high-risk patients using an accessible bedside investigation. A LUS score >3 and low MMSE should prompt preventive measures. Further studies should validate these findings and explore pathophysiology.
谵妄是一种急性精神错乱状态,在住院的老年COVID-19患者中很常见,并与不良预后有关。尽管如此,由于症状与痴呆症重叠,诊断不足仍然存在。本研究探讨肺超声(LUS)和认知筛查是否可以预测老年COVID-19患者谵妄风险。方法在圣路易吉医院进行一项前瞻性研究,纳入64例COVID-19患者,平均年龄82.6岁。肺受累评估使用LUS扩展评分(LUSext),而认知评估通过MMSE和4AT测试。分析临床资料,包括合并症和炎症标志物。ROC曲线和多元回归确定谵妄的预测因子。结果谵妄发生率为61.4%(35/57)。单因素分析将谵妄与先前存在的痴呆(p = 0.03)、较高的LUS评分(p = 0.004)和较低的MMSE评分(p = 0.0002)联系起来。LUS评分>;3(敏感性74%,特异性82%)最能预测谵妄。多因素分析证实LUS >;3 (OR=4.22, p = 0.023)和MMSE较低(OR=0.87, p = 0.007)为独立危险因素。lus和认知障碍是老年COVID-19患者谵妄的有力预测因素。LUSext评分为肺病理严重程度提供了客观、快速的床边测量,评分为>;3表示谵妄风险显著升高。低MMSE和谵妄之间的联系强调了认知脆弱性。结论虽然谵妄是多因素的,但在资源有限的情况下,将LUS纳入常规评估可改善早期发现和管理,并通过可获取的床边调查有效识别高危患者。LUS得分>;3和低MMSE应该提示预防措施。进一步的研究应该验证这些发现并探索病理生理学。
{"title":"Lung ultrasound (LUS) as a predictor of delirium in elderly patients with COVID-19 during hospitalization: A geriatric vulnerability-stress model","authors":"Thomas Fraccalini MD , Isa Rita Bergoglio MD, PhD , Gianfranco Fonte MD, PhD , Andrea Trogolo MD , Alessandro Maraschi MD , Thomas Roberts , Beatrice Tarozzo PsyD , Beatriz Vitorino MS , Julia Michelin Vecchini MS , Santoro Mariangela MD , Monica Traversa MD, PhD , Teresa Crea MD , Luciano Cardinale MD, PhD , Giuseppe Maina MD , Valerio Ricci MD, PhD , Elisa Binello CNO , Reald Turja NU , Federico Mallamaci NU , Giovanni Volpicelli MD","doi":"10.1016/j.aggp.2025.100186","DOIUrl":"10.1016/j.aggp.2025.100186","url":null,"abstract":"<div><h3>Introduction</h3><div>Delirium, an acute confusional state, is common in elderly hospitalized COVID-19 patients and is linked to poor outcomes. Despite this, underdiagnosis persists due to symptom overlap with dementia. This study investigates whether lung ultrasound (LUS) and cognitive screening can predict delirium risk in elderly COVID-19 patients.</div></div><div><h3>Methods</h3><div>A prospective study at San Luigi Hospital enrolled 64 COVID-19 patients (mean age 82.6). Pulmonary involvement was assessed using the LUS Extension Score (LUSext), while cognition was evaluated via MMSE and 4AT tests. Clinical data, including comorbidities and inflammatory markers, were analyzed. ROC curves and multivariate regression identified delirium predictors.</div></div><div><h3>Results</h3><div>Delirium occurred in 61.4 % (35/57). Univariate analysis linked delirium to pre-existing dementia (<em>p</em> = 0.03), higher LUS scores (<em>p</em> = 0.004), and lower MMSE scores (<em>p</em> = 0.0002). A LUS score >3 (sensitivity 74 %, specificity 82 %) best predicted delirium. Multivariate analysis confirmed LUS >3 (OR=4.22, <em>p</em> = 0.023) and lower MMSE (OR=0.87, <em>p</em> = 0.007) as independent risk factors.</div></div><div><h3>Discussion</h3><div>LUS and cognitive impairment are strong predictors of delirium in elderly COVID-19 patients. The LUSext score provides an objective, rapid bedside measure of lung pathology severity, with a score >3 indicating significantly elevated delirium risk. The link between low MMSE and delirium underscores cognitive vulnerability.</div></div><div><h3>Conclusion</h3><div>While delirium is multifactorial, integrating LUS into routine assessment may improve early detection and management in resource-limited settings, effectively identifying high-risk patients using an accessible bedside investigation. A LUS score >3 and low MMSE should prompt preventive measures. Further studies should validate these findings and explore pathophysiology.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-24DOI: 10.1016/j.aggp.2025.100185
Henry Sutanto
Polypharmacy among geriatric patients poses significant clinical and economic challenges, including increased risks of adverse drug reactions, cognitive decline, and hospitalizations. While raising physician awareness is necessary, it is insufficient on its own. This narrative review highlights the importance of comprehensive, evidence-based interventions to optimize medication management. Tools such as the Beers Criteria, STOPP/START guidelines, Anticholinergic Cognitive Burden (ACB) scale, and Drug Burden Index (DBI) are essential for identifying potentially inappropriate medications and reducing medication-related harm. The review underscores the need for structured medication reviews, deprescribing protocols, and individualized care planning. Furthermore, clinical decision support tools (CDSS) enhance prescribing safety by identifying drug-drug interactions and recommending safer alternatives. Systemic reforms—like policy incentives for deprescribing, medication reconciliation programs, and telemedicine-enabled interventions—support continuity of care and improve adherence. Interdisciplinary collaboration, involving pharmacists, nurses, and geriatricians, is critical for effective polypharmacy management. In low- and middle-income countries (LMICs), tailored solutions such as task-shifting, simplified prescribing protocols, and culturally sensitive education are emphasized. Overall, the article advocates for a comprehensive approach that combines clinical tools, systemic strategies, and collaborative care to ensure safer, more effective pharmacotherapy for older adults.
{"title":"Tackling polypharmacy in geriatric patients: Is increasing physicians’ awareness adequate?","authors":"Henry Sutanto","doi":"10.1016/j.aggp.2025.100185","DOIUrl":"10.1016/j.aggp.2025.100185","url":null,"abstract":"<div><div>Polypharmacy among geriatric patients poses significant clinical and economic challenges, including increased risks of adverse drug reactions, cognitive decline, and hospitalizations. While raising physician awareness is necessary, it is insufficient on its own. This narrative review highlights the importance of comprehensive, evidence-based interventions to optimize medication management. Tools such as the Beers Criteria, STOPP/START guidelines, Anticholinergic Cognitive Burden (ACB) scale, and Drug Burden Index (DBI) are essential for identifying potentially inappropriate medications and reducing medication-related harm. The review underscores the need for structured medication reviews, deprescribing protocols, and individualized care planning. Furthermore, clinical decision support tools (CDSS) enhance prescribing safety by identifying drug-drug interactions and recommending safer alternatives. Systemic reforms—like policy incentives for deprescribing, medication reconciliation programs, and telemedicine-enabled interventions—support continuity of care and improve adherence. Interdisciplinary collaboration, involving pharmacists, nurses, and geriatricians, is critical for effective polypharmacy management. In low- and middle-income countries (LMICs), tailored solutions such as task-shifting, simplified prescribing protocols, and culturally sensitive education are emphasized. Overall, the article advocates for a comprehensive approach that combines clinical tools, systemic strategies, and collaborative care to ensure safer, more effective pharmacotherapy for older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Older women experience higher rates of disability compared to men. This gender disparity is linked to varying risk factors. The objective of this study is to investigate gender differences in disability among older adults in India
Methods
For this study, we used Longitudinal Ageing Study of India, Wave 1 (2017–2018) data, a nationally representative dataset of older persons age 60 years and above. Both descriptive and inferential statistics are used to analysis the data.
Results
Our findings indicate that older women report higher rates of vision, hearing, difficulty in chewing solid food, and physical disabilities, contributing to the observed gender differences in disability. Among these, vision impairment is the most prevalent. Notably, women with fewer years of schooling and those living in households in the lower wealth quintiles exhibit the highest levels of disability. Additionally, older individuals who are of advanced age, widowed, living in urban areas or alone, currently employed, or who experienced poor childhood health are more likely to report disabilities.
Conclusion
The higher prevalence of disability among women is the result of a combination of demographic and socioeconomic factors. These findings serve as a wake-up call for researchers and policymakers to prioritize gender-sensitive interventions aimed at preventing disability among older adults.
{"title":"Gender differences in disability among older persons in India: Evidence from the longitudinal ageing study in India (LASI)","authors":"Kinkar Mandal PhD (Assistant Professor) , Lekha Subaiya PhD (Professor)","doi":"10.1016/j.aggp.2025.100183","DOIUrl":"10.1016/j.aggp.2025.100183","url":null,"abstract":"<div><h3>Background</h3><div>Older women experience higher rates of disability compared to men. This gender disparity is linked to varying risk factors. The objective of this study is to investigate gender differences in disability among older adults in India</div></div><div><h3>Methods</h3><div>For this study, we used Longitudinal Ageing Study of India, Wave 1 (2017–2018) data, a nationally representative dataset of older persons age 60 years and above. Both descriptive and inferential statistics are used to analysis the data.</div></div><div><h3>Results</h3><div>Our findings indicate that older women report higher rates of vision, hearing, difficulty in chewing solid food, and physical disabilities, contributing to the observed gender differences in disability. Among these, vision impairment is the most prevalent. Notably, women with fewer years of schooling and those living in households in the lower wealth quintiles exhibit the highest levels of disability. Additionally, older individuals who are of advanced age, widowed, living in urban areas or alone, currently employed, or who experienced poor childhood health are more likely to report disabilities.</div></div><div><h3>Conclusion</h3><div>The higher prevalence of disability among women is the result of a combination of demographic and socioeconomic factors. These findings serve as a wake-up call for researchers and policymakers to prioritize gender-sensitive interventions aimed at preventing disability among older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-19DOI: 10.1016/j.aggp.2025.100182
Madhurima Sharma, Abdul Fathah, Indrajit Goswami
Background
While cognitive impairment (CI) and dementia are among the most severe morbid conditions in later life, life expectancies free from CI have been much less investigated than measures of physical functioning. This study aimed to determine the health expectancies in middle aged and older adults in India, considering cognitive status as a health indicator.
Methods
We estimated Cognitive Impairment-free life expectancy (CIFLE) in India for people aged 45 and older using data from Longitudinal Ageing Study in India (LASI), 2017-18. Mortality data has been derived from the Sample Registration System (SRS), 2016-20. Sullivan’s method is used to estimate the average number of years a person can expect to live with and without cognitive impairment.
Results
The prevalence of CI among Indian adults 45 and above is 10.28 %, increasing from 4.34 % (45–49) to 47 % (85+). Higher rates in females (13.65 % vs 6.42 % in males) and rural areas (12.39 % vs 6.38 % urban). The results indicate that after attaining age 60, males are expected to live 15 more years as cognitive impairment-free, which is only 12 years for females; though life expectancy for females is higher than that of males. Older adults in rural areas are expected to have fewer cognitive impairment-free years than in urban areas.
Conclusion
Longer life does not extend cognitive health. CI reduces quality of life and increases care needs, aligning with global trends. The disparities in CI-free life expectancy between genders and rural-urban areas highlight the need for targeted interventions and policies to address cognitive health inequalities in India.
虽然认知障碍(CI)和痴呆是晚年生活中最严重的疾病,但对无CI的预期寿命的研究远远少于对身体功能的研究。本研究旨在确定在印度中老年人的健康预期,考虑到认知状况作为一个健康指标。方法我们使用2017-18年印度纵向老龄化研究(LASI)的数据估计印度45岁及以上人群的无认知障碍预期寿命(CIFLE)。死亡率数据来自2016-20年样本登记系统(SRS)。沙利文的方法被用来估计一个人有或没有认知障碍的平均寿命。结果印度45岁及以上成人CI患病率为10.28 %,由4.34 %(45 - 49)上升至47 %(85+)。女性(13.65 % vs . 6.42 %)和农村地区(12.39 % vs . 6.38 %)的发病率较高。结果表明,60岁后,男性无认知障碍预期寿命为15年,而女性仅为12年;尽管女性的预期寿命高于男性。预计农村地区的老年人无认知障碍的年数将少于城市地区的老年人。结论延长寿命并不能延长认知健康。CI降低了生活质量并增加了护理需求,这与全球趋势一致。性别之间和城乡之间在无ci预期寿命方面的差异突出表明,印度需要采取有针对性的干预措施和政策,以解决认知健康方面的不平等问题。
{"title":"Cognitive-impairment-free life expectancy (CIFLE) among older adults in India: A gender and residence based study","authors":"Madhurima Sharma, Abdul Fathah, Indrajit Goswami","doi":"10.1016/j.aggp.2025.100182","DOIUrl":"10.1016/j.aggp.2025.100182","url":null,"abstract":"<div><h3>Background</h3><div>While cognitive impairment (CI) and dementia are among the most severe morbid conditions in later life, life expectancies free from CI have been much less investigated than measures of physical functioning. This study aimed to determine the health expectancies in middle aged and older adults in India, considering cognitive status as a health indicator.</div></div><div><h3>Methods</h3><div>We estimated Cognitive Impairment-free life expectancy (CIFLE) in India for people aged 45 and older using data from Longitudinal Ageing Study in India (LASI), 2017-18. Mortality data has been derived from the Sample Registration System (SRS), 2016-20. Sullivan’s method is used to estimate the average number of years a person can expect to live with and without cognitive impairment.</div></div><div><h3>Results</h3><div>The prevalence of CI among Indian adults 45 and above is 10.28 %, increasing from 4.34 % (45–49) to 47 % (85+). Higher rates in females (13.65 % vs 6.42 % in males) and rural areas (12.39 % vs 6.38 % urban). The results indicate that after attaining age 60, males are expected to live 15 more years as cognitive impairment-free, which is only 12 years for females; though life expectancy for females is higher than that of males. Older adults in rural areas are expected to have fewer cognitive impairment-free years than in urban areas.</div></div><div><h3>Conclusion</h3><div>Longer life does not extend cognitive health. CI reduces quality of life and increases care needs, aligning with global trends. The disparities in CI-free life expectancy between genders and rural-urban areas highlight the need for targeted interventions and policies to address cognitive health inequalities in India.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This cross-sectional observational study aimed to identify factors associated with frailty status in community-dwelling older adults. A total of 188 older adults (mean age: 75.9 ± 6.7 years) attending municipal exercise facilities between 2019 and 2022 were included. Data were collected on participants' basic characteristics, physical fitness, and scores from the Kihon Checklist (KCL). Frailty status was classified into robust (KCL score ≤3), pre-frail (4–7), and frail (≥8) groups based on established criteria. Group differences were analyzed using the Kruskal–Wallis test with Bonferroni correction for multiple comparisons. Significant differences among the robust, pre-frail, and frail groups were observed in most physical fitness and frailty-related items, particularly grip strength, walking ability, and lifestyle-related functions, except for cognition and depression. These findings indicate that specific domains of physical function are significantly associated with frailty status. Interventions targeting a broad range of physical fitness factors are essential to mitigate frailty in older adults.
{"title":"Factors associated with frailty progression in community-dwelling older adults: A cross-sectional observational study","authors":"Yuko Sawada , Akihiro Kakuda , Emiko Tanaka , Etsuko Tomisaki , Taeko Watanabe , Munenori Matsumoto , Rika Okumura , Hiroshi Kinoshita , Tokie Anme","doi":"10.1016/j.aggp.2025.100179","DOIUrl":"10.1016/j.aggp.2025.100179","url":null,"abstract":"<div><div>This cross-sectional observational study aimed to identify factors associated with frailty status in community-dwelling older adults. A total of 188 older adults (mean age: 75.9 ± 6.7 years) attending municipal exercise facilities between 2019 and 2022 were included. Data were collected on participants' basic characteristics, physical fitness, and scores from the Kihon Checklist (KCL). Frailty status was classified into robust (KCL score ≤3), pre-frail (4–7), and frail (≥8) groups based on established criteria. Group differences were analyzed using the Kruskal–Wallis test with Bonferroni correction for multiple comparisons. Significant differences among the robust, pre-frail, and frail groups were observed in most physical fitness and frailty-related items, particularly grip strength, walking ability, and lifestyle-related functions, except for cognition and depression. These findings indicate that specific domains of physical function are significantly associated with frailty status. Interventions targeting a broad range of physical fitness factors are essential to mitigate frailty in older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-15DOI: 10.1016/j.aggp.2025.100180
Jay Acharya , Radcliffe Lisk , Rashid Mahmood , Amir Manzoor , Francesca Young , Mitveer Gill , Keefai Yeong , Kevin Kelly , Jonathan Robin , David Fluck , Christopher Henry Fry , Thang Sieu Han
Background
Frailty and delirium commonly coexist in acutely ill older adults, but they are variably measured. The Clinical Frailty Scale (CFS) and the 4AT scores are advocated as standardised tools to assess these conditions. We have developed risk categories based on these scales to predict mortality.
Methods
Two-graph ROC curve analysis derived thresholds at 5.5 for CFS and 1 for 4AT for predicting mortality, from which three composite Risk-Categories were created: “Low-Risk” represents low scores for both CFS (1–6) and 4AT (0); Intermediate-Risk” represents either high CFS (7–9) or high 4AT (1–12) scores; and High-Risk” represents both high CFS and 4AT scales. These Risk-Categories were used to predict in-hospital or 30-day mortality using logistic regression, and up to 27 months since admission using Cox regression; adjusted for age, sex, Charlson comorbidity index, anticholinergic burden and polypharmacy.
Results
There were 1192 patients (57.1 % women) of mean age 86.1 yr (SD=7.1) consecutively admitted to a hospital. Compared to those in the “Low-Risk” category (reference), in-hospital mortality odds-ratios (ORs; 95 %CI) were greater for those in the “Intermediate-Risk” category: OR=1.74 (1.11–2.72), and “High-Risk” category: OR=2.72 (1.47–5.02). Corresponding values for within 30-day mortality were: OR=1.75 (1.18–2.60) and OR=3.03 (1.76–5.21). Risk of death within 27 months of admission was increased in the “High-Risk” category: hazard ratio=1.46 (1.14–1.87). The association of CFS and mortality was partially mediated by 4AT.
Conclusion
Mortality in hospital was approximately doubled in “Intermediate-Risk” and tripled in “High-Risk” patients, which persisted after discharge. These risk categories are a useful tool for identifying high-risk patients.
{"title":"Frailty and delirium: A fatal combination in older adults","authors":"Jay Acharya , Radcliffe Lisk , Rashid Mahmood , Amir Manzoor , Francesca Young , Mitveer Gill , Keefai Yeong , Kevin Kelly , Jonathan Robin , David Fluck , Christopher Henry Fry , Thang Sieu Han","doi":"10.1016/j.aggp.2025.100180","DOIUrl":"10.1016/j.aggp.2025.100180","url":null,"abstract":"<div><h3>Background</h3><div>Frailty and delirium commonly coexist in acutely ill older adults, but they are variably measured. The Clinical Frailty Scale (CFS) and the 4AT scores are advocated as standardised tools to assess these conditions. We have developed risk categories based on these scales to predict mortality.</div></div><div><h3>Methods</h3><div>Two-graph ROC curve analysis derived thresholds at 5.5 for CFS and 1 for 4AT for predicting mortality, from which three composite <em>Risk-Categories</em> were created: “<em>Low-Risk</em>” represents low scores for both CFS (1–6) and 4AT (0); <em>Intermediate-Risk”</em> represents either high CFS (7–9) or high 4AT (1–12) scores; and <em>High-Risk</em>” represents both high CFS and 4AT scales. These <em>Risk-Categories</em> were used to predict in-hospital or 30-day mortality using logistic regression, and up to 27 months since admission using Cox regression; adjusted for age, sex, Charlson comorbidity index, anticholinergic burden and polypharmacy.</div></div><div><h3>Results</h3><div>There were 1192 patients (57.1 % women) of mean age 86.1 yr (SD=7.1) consecutively admitted to a hospital. Compared to those in the “<em>Low-Risk</em>” category (reference), in-hospital mortality odds-ratios (ORs; 95 %CI) were greater for those in the “<em>Intermediate-Risk”</em> category: OR=1.74 (1.11–2.72), and “<em>High-Risk</em>” category: OR=2.72 (1.47–5.02). Corresponding values for within 30-day mortality were: OR=1.75 (1.18–2.60) and OR=3.03 (1.76–5.21). Risk of death within 27 months of admission was increased in the “<em>High-Risk</em>” category: hazard ratio=1.46 (1.14–1.87). The association of CFS and mortality was partially mediated by 4AT.</div></div><div><h3>Conclusion</h3><div>Mortality in hospital was approximately doubled in “<em>Intermediate-Risk</em>” and tripled in “<em>High-Risk</em>” patients, which persisted after discharge. These risk categories are a useful tool for identifying high-risk patients.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-11DOI: 10.1016/j.aggp.2025.100176
Victoria Sánchez-Cazalla , Tamara Gutiérrez-Domingo
Introduction
Ageing is a process that covers the entire life cycle of a human being and that, around old age, is usually accompanied by negative stereotypes, social isolation and a feeling of loneliness, resulting in a rupture between diverse generations. Intergenerational programs have been used to address this concern to pursue active ageing.
Objetive
Analyze the impact of intergenerational programs on the ageing process to achieve cohesive societies for all ages and thus promote the active ageing model.
Material and methods
A systematic review has been prepared, the search of which was carried out in the Pubmed, Web of Science, Scopus, PsycINFO, and Cochrane Libary databases, that included studies published between 2014 and 2025. A total of 3.144 articles were identified, of which 290 underwent selection according to title and abstract, leaving 72 that were evaluated for eligibility, according to the inclusion criteria.
Results
A total of 8 articles were valid for inclusion. The methodological quality of the studies was low to moderate, although most research reported improvements in participants' well-being after participation in an intergenerational program.
Conclusions
Intergenerational programs provided biopsychosocial benefits to generations of different ages, which helped enhance the pursuit of active ageing in order to establish strong connections in the community.
老龄化是一个涵盖人的整个生命周期的过程,在老年前后,通常伴随着消极的陈规定型观念、社会孤立和孤独感,导致不同世代之间的破裂。代际项目已被用来解决这一问题,以追求积极老龄化。目的分析代际计划对老龄化进程的影响,以实现所有年龄段的凝聚力社会,从而促进积极老龄化模式。材料和方法已经准备了一项系统综述,在Pubmed、Web of Science、Scopus、PsycINFO和Cochrane library数据库中进行了检索,包括2014年至2025年间发表的研究。共纳入文献3.144篇,其中290篇根据标题和摘要进行筛选,其余72篇根据纳入标准进行入选评价。结果共8篇有效纳入。研究的方法学质量是低到中等,尽管大多数研究报告参与者在参与代际项目后的幸福感有所改善。结论代际计划为不同年龄的人提供了生物心理社会效益,有助于增强对积极老龄化的追求,从而在社区中建立牢固的联系。
{"title":"Impact of intergenerational programmes on older adults for active ageing. A systematic review","authors":"Victoria Sánchez-Cazalla , Tamara Gutiérrez-Domingo","doi":"10.1016/j.aggp.2025.100176","DOIUrl":"10.1016/j.aggp.2025.100176","url":null,"abstract":"<div><h3>Introduction</h3><div>Ageing is a process that covers the entire life cycle of a human being and that, around old age, is usually accompanied by negative stereotypes, social isolation and a feeling of loneliness, resulting in a rupture between diverse generations. Intergenerational programs have been used to address this concern to pursue active ageing.</div></div><div><h3>Objetive</h3><div>Analyze the impact of intergenerational programs on the ageing process to achieve cohesive societies for all ages and thus promote the active ageing model.</div></div><div><h3>Material and methods</h3><div>A systematic review has been prepared, the search of which was carried out in the Pubmed, Web of Science, Scopus, PsycINFO, and Cochrane Libary databases, that included studies published between 2014 and 2025. A total of 3.144 articles were identified, of which 290 underwent selection according to title and abstract, leaving 72 that were evaluated for eligibility, according to the inclusion criteria.</div></div><div><h3>Results</h3><div>A total of 8 articles were valid for inclusion. The methodological quality of the studies was low to moderate, although most research reported improvements in participants' well-being after participation in an intergenerational program.</div></div><div><h3>Conclusions</h3><div>Intergenerational programs provided biopsychosocial benefits to generations of different ages, which helped enhance the pursuit of active ageing in order to establish strong connections in the community.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intergenerational mediation has significant implications for the well-being and quality of life of older adults and their families. Literature has emerged relating to the complexities of mediation practices and their effectiveness in addressing diverse issues older adults face. This scoping review aims to synthesize existing research on intergenerational mediation and explore, assess, and map key concepts related to mediating conflicts within later-life families. Databases, including PsychINFO, EMBASE, MEDLINE and CINAHL; Sociological Abstracts and International Bibliography of Social Sciences, were searched (as of Febraury 6th, 2024) and 930 titles and abstracts were identified. Of these, 44 met the inclusion criteria.
In this paper, the aim is to synthesize existing research on intergenerational mediation, mapping key concepts and identifying the gaps in literature across various articles and studies. Scoping review allows for a broader inclusion of different types of studies, without needing to assess methodological quality as a systemic review would, this makes systematic review less appropriate, especially if the studies are still emerging.
Seven themes emerged in the review of the literature: (a) mediation practice and guidelines; (b) sources of family conflict; (c) prevention of elder abuse and neglect; (d) family dynamics; (e) ethics; (f) mediation and law; and (g) implications for social work practice. The scoping review identified research gaps, including limited articles on intergenerational mediation across different cultures, religions, and geographic contexts. Due to the lack of consistent definitions of elder abuse in many countries, research is limited, highlighting the need for future research. The literature lacks sufficient exploration of the intersection of mediating conflicts and the older adults' aging process. Findings from this scoping review can inform best practices for intergenerational mediation and older adults’ aging.
Mediation provides a confidential space for collaborative discussions, aiding to prevent elder abuse and empower older adults. This review underscores the multifaceted role of mediation in social work, highlighting its potential to enhance care for older adults and their families.
{"title":"Addressing conflicts in later life through intergenerational mediation: A scoping review","authors":"Arezo Feroz, Amanda Oliveri, Marley Goldenberg, Gagan Takhar, Michelle Hur, Jamie-Leigh LeTourneau","doi":"10.1016/j.aggp.2025.100178","DOIUrl":"10.1016/j.aggp.2025.100178","url":null,"abstract":"<div><div>Intergenerational mediation has significant implications for the well-being and quality of life of older adults and their families. Literature has emerged relating to the complexities of mediation practices and their effectiveness in addressing diverse issues older adults face. This scoping review aims to synthesize existing research on intergenerational mediation and explore, assess, and map key concepts related to mediating conflicts within later-life families. Databases, including PsychINFO, EMBASE, MEDLINE and CINAHL; Sociological Abstracts and International Bibliography of Social Sciences, were searched (as of Febraury 6th, 2024) and 930 titles and abstracts were identified. Of these, 44 met the inclusion criteria.</div><div>In this paper, the aim is to synthesize existing research on intergenerational mediation, mapping key concepts and identifying the gaps in literature across various articles and studies. Scoping review allows for a broader inclusion of different types of studies, without needing to assess methodological quality as a systemic review would, this makes systematic review less appropriate, especially if the studies are still emerging.</div><div>Seven themes emerged in the review of the literature: (a) mediation practice and guidelines; (b) sources of family conflict; (c) prevention of elder abuse and neglect; (d) family dynamics; (e) ethics; (f) mediation and law; and (g) implications for social work practice. The scoping review identified research gaps, including limited articles on intergenerational mediation across different cultures, religions, and geographic contexts. Due to the lack of consistent definitions of elder abuse in many countries, research is limited, highlighting the need for future research. The literature lacks sufficient exploration of the intersection of mediating conflicts and the older adults' aging process. Findings from this scoping review can inform best practices for intergenerational mediation and older adults’ aging.</div><div>Mediation provides a confidential space for collaborative discussions, aiding to prevent elder abuse and empower older adults. This review underscores the multifaceted role of mediation in social work, highlighting its potential to enhance care for older adults and their families.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-06DOI: 10.1016/j.aggp.2025.100173
Thomas Fraccalini , Andrea Trogolo , Monica Traversa , Beatrice Tarozzo , Luciano Cardinale , Giuseppe Maina , Salvatore Di Gioia , Davide Minniti , Ivana Finiguerra , Roberta Vacchelli , Martina Battaglia , Angelica Ruggeri , Valerio Ricci , Alessandro Maraschi , Thomas Roberts , Giovanni Volpicelli , Luca Tagliafico
{"title":"Corrigendum to “Delirium in the emergency department: Incidence and risk factors in a Ligurian hospital” [Archives of Gerontology and Geriatrics Plus Volume 2, Issue 2, June 2025, 100165]","authors":"Thomas Fraccalini , Andrea Trogolo , Monica Traversa , Beatrice Tarozzo , Luciano Cardinale , Giuseppe Maina , Salvatore Di Gioia , Davide Minniti , Ivana Finiguerra , Roberta Vacchelli , Martina Battaglia , Angelica Ruggeri , Valerio Ricci , Alessandro Maraschi , Thomas Roberts , Giovanni Volpicelli , Luca Tagliafico","doi":"10.1016/j.aggp.2025.100173","DOIUrl":"10.1016/j.aggp.2025.100173","url":null,"abstract":"","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-04DOI: 10.1016/j.aggp.2025.100175
Brittany Stahnke , Roxxi Davis , Morgan Cooley , Porsha Farmer
There is little research focused on the knowledge that those in the last stage of their lives can offer. The last phase of life brings with it unique wisdom and life advice that can be used to guide all people in their journeys. The purpose of this study was to provide scholarship detailing advice and learnings of those in this unique and final life stage. Nine participants were interviewed in the year 2021, and transcripts were analyzed in an interpretative phenomenological manner. Main themes of life suffering and values presented with sub-themes including illness, loss, family, faith, and purpose. The importance of choice in the lives we live, as well as hard work supports the abilities to succeed in valued areas. Family was stated to be the most important part of these lives; however, with or without family, one also benefits from a sense of accomplishment and pride in themselves.
{"title":"Reflections of those who have lived: Phenomenological perspectives from adults at end-of-life from an Eriksonian lens","authors":"Brittany Stahnke , Roxxi Davis , Morgan Cooley , Porsha Farmer","doi":"10.1016/j.aggp.2025.100175","DOIUrl":"10.1016/j.aggp.2025.100175","url":null,"abstract":"<div><div>There is little research focused on the knowledge that those in the last stage of their lives can offer. The last phase of life brings with it unique wisdom and life advice that can be used to guide all people in their journeys. The purpose of this study was to provide scholarship detailing advice and learnings of those in this unique and final life stage. Nine participants were interviewed in the year 2021, and transcripts were analyzed in an interpretative phenomenological manner. Main themes of life suffering and values presented with sub-themes including illness, loss, family, faith, and purpose. The importance of choice in the lives we live, as well as hard work supports the abilities to succeed in valued areas. Family was stated to be the most important part of these lives; however, with or without family, one also benefits from a sense of accomplishment and pride in themselves.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}