Archives of Gerontology and Geriatrics Plus最新文献

{"title":"Coronary heart disease racial disparities among older adults in the U.S.: Systematic review, 2000-2024","authors":"Sanggon Nam","doi":"10.1016/j.aggp.2025.100194","DOIUrl":"10.1016/j.aggp.2025.100194","url":null,"abstract":"<div><h3>Background</h3><div>Coronary heart disease (CHD) remains a leading cause of morbidity and mortality among older U.S. adults, with significant racial and ethnic disparities in prevalence, treatment, and outcomes. This systematic review synthesizes evidence from 44 studies published between 2000 and 2024 to examine these disparities among adults aged ≥65, focusing on prevalence, access to care, treatment quality, outcomes, contributing factors, and effective interventions.</div></div><div><h3>Methods</h3><div>The review adhered to PRISMA 2020 guidelines. A comprehensive search was conducted across six databases: PubMed, Embase, Scopus, Web of Science, CINAHL, and the Cochrane Library. Studies were included if they examined racial/ethnic differences in CHD among U.S. adults aged ≥65. Two independent reviewers screened titles and abstracts, followed by full-text review, with disagreements resolved by a third reviewer. Inter-rater reliability was assessed using Cohen’s kappa (0.85 for title/abstract, 0.90 for full-text). Quality assessment used the Newcastle-Ottawa Scale (NOS; high quality ≥7 points, moderate 4–6 points, low ≤3 points) for observational studies and the Cochrane Risk of Bias tool for randomized trials. Due to heterogeneity, a narrative synthesis was conducted, with subgroup analyses for key outcomes.</div></div><div><h3>Results</h3><div>The 44 included studies revealed persistent disparities in CHD prevalence, access, treatment, and outcomes, particularly affecting Black, Hispanic, and American Indian/Alaska Native (AI/AN) older adults. Minority groups exhibited higher CHD prevalence and risk factors (e.g., hypertension, diabetes), lower access to guideline-directed therapies, and worse outcomes, including higher readmission and mortality rates. Structural racism, socioeconomic factors, and systemic biases were key drivers. Interventions like policy reforms, community-based programs, and telehealth showed promise in reducing disparities.</div></div><div><h3>Conclusions</h3><div>Despite progress in acute care, significant disparities persist in long-term CHD management among minority older adults. Addressing social determinants, improving access to equitable care, and implementing culturally competent interventions are essential for health equity.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can targeted cognitive intervention improve rehabilitation outcome in hip fracture patients: a randomized controlled trial","authors":"Yedida Borow,&nbsp;Renata Efrati,&nbsp;Noa Doron,&nbsp;Michal Tzin,&nbsp;Yaara Ginsburg,&nbsp;Daniela Gesner,&nbsp;Avital Hershkovitz","doi":"10.1016/j.aggp.2025.100193","DOIUrl":"10.1016/j.aggp.2025.100193","url":null,"abstract":"<div><h3>Background</h3><div>Hip fractures lead to disability, loss of independence, and a decline in quality of life. Rehabilitation success depends on various factors, such as, age, pre-fracture function, level of cognitive function, nutritional status, comorbidity, and family support. Most studies exploring the question of whether cognitive-based interventions can lead to functional improvement were conducted on community-dwelling elderly individuals with acquired brain injury, dementia, and cognitive impairments. Our aim was to compare targeted cognitive intervention with conventional occupational therapy in improving rehabilitation outcomes amongst post-acute hip fracture patients.</div></div><div><h3>Methods</h3><div>A randomized controlled single blinded study. Eighty patients were randomly assigned to two groups: group A (intervention) received targeted cognitive intervention, based on concepts from \"The multi-context approach to cognitive rehabilitation of executive dysfunction\" and group B (controls) received conventional occupational therapy. T-test and chi-square tests assessed significant differences between demographic, clinical, functional variables. ANOVA with repeated measures assessed significant improvement in cognitive/functional test scores in the two groups.</div></div><div><h3>Results</h3><div>43 patients were assigned to the intervention group; 37 to the controls. All patients significantly improved in their cognitive tests. No significant differences were found between the groups regarding discharge scores of the cognitive test, degree of cognitive improvement, functional outcomes and patient reported outcome measures questions.</div></div><div><h3>Conclusions</h3><div>Targeted cognitive intervention did not lead to a better outcome in hip fracture patients. As most were cognitively impaired, further research is warranted in order to explore whether different cognitive interventions might improve their rehabilitation outcomes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A UK study: Menopausal and perimenopausal women’s biopsychosocial experiences, understanding of treatment options, and thoughts towards their future lives","authors":"Mandy Simpson,&nbsp;Cynthia Tuuli,&nbsp;Elizabeth Eate","doi":"10.1016/j.aggp.2025.100191","DOIUrl":"10.1016/j.aggp.2025.100191","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to draw attention and give voice to women’s experiences, knowledge, future thoughts and general understanding of perimenopause and menopause, exploring this natural event holistically through a biopsychosocial lens.</div></div><div><h3>Methods</h3><div>One focus group of four self-identified perimenopausal or menopausal women was conducted to gather data. Purposive sampling was used to recruit the participants through a social media campaign. Interpretative Phenomenological Analysis provided a framework to study this important topic through exploring and examining lived experiences in a small group sample size, using the framework’s seven-step data analysis to identify key themes within the data.</div></div><div><h3>Results</h3><div>Four main group experiential themes were highlighted through analysis of the participants' responses: (1) onset and impact of symptoms, (2) menopause and relationships, (3) the knowledge gap, and (4) future thoughts: a desire for change. A prominent overarching theme involved the participants showing less concern for how they were being personally affected by their climacteric experience but demonstrating greater concern for the impact of their perimenopause or menopause experience upon others. This overarching theme was evident within all four group experiential themes.</div></div><div><h3>Conclusions</h3><div>The participants were deeply concerned about how their symptoms affected others. They had limited knowledge when their own symptoms started, but after seeking support, particularly from people with lived experiences rather than academic literature, they became inspired to be a part of bringing about change for the next generation, so that in the future menopause experiences would not occur so unexpectedly for others.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating inflammaging: The bidirectional relationship between oral and systemic health in geriatric prosthodontics","authors":"Olga Naka,&nbsp;Panagiota Chatzidou,&nbsp;Katia Sarafidou,&nbsp;Vassiliki Anastassiadou","doi":"10.1016/j.aggp.2025.100192","DOIUrl":"10.1016/j.aggp.2025.100192","url":null,"abstract":"<div><div>The aging population presents complex challenges to oral health, particularly due to inflammaging, a chronic, low-grade systemic inflammation linked to tissue degeneration and frailty syndrome. Despite its relevance, inflammaging remains underexplored in geriatric prosthodontics. This scoping review aimed to systematically examine and classify existing literature on oral-systemic inflammaging, with emphasis on diagnostic biomarkers, therapeutic strategies, and interdisciplinary integration. Bloom’s cognitive taxonomy was used to structure the evidence according to levels of complexity and clinical application. Following the PRISMA-ScR guidelines, 1686 records were screened across four databases (PubMed, Scopus, Web of Science, and Embase), and 49 studies met the inclusion criteria. The review employed a dual framework: the PICO model for clinical relevance and Bloom’s instructional taxonomy to categorize evidence from recall-level biological markers to higher-order insights, such as senotherapeutics, multi-omics diagnostics, and digital integration. Findings highlighted strong correlations between systemic inflammatory markers and oral aging conditions. Novel interventions, including senolytics, mTOR inhibitors, and microbiome-targeted therapies, showed translational promise. However, gaps persist in standardized biomarker panels, long-term clinical trials, and integration of frailty metrics into prosthodontic care. In conclusion, inflammaging offers a compelling biological perspective for transitioning prosthodontic strategies from mechanical approaches to precision-based methodologies. Integrating concepts including geroscience, salivary diagnostics, and personalized biomaterials can enhance outcomes and resilience in older adults. Future research should prioritize biologically informed protocols, interdisciplinary collaboration, and AI-supported predictive tools to align prosthodontics with the broader goals of healthy aging.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a Protection Motivation Theory-based intervention to promote life planning and reduce ageism among younger people","authors":"Yuho Shimizu","doi":"10.1016/j.aggp.2025.100189","DOIUrl":"10.1016/j.aggp.2025.100189","url":null,"abstract":"<div><div>Previous studies have developed interventions aimed at simultaneously promoting long-term life planning and reducing ageism among younger individuals. Building on this work, the present study developed a novel intervention based on Protection Motivation Theory and evaluated its effectiveness in a sample of younger participants (<em>N</em> = 498). The intervention comprised the following components: a free-writing task addressing potential negative future events (to target threat appraisal), an explanatory text aimed at reducing ageism, a free-writing task designed to enhance hope for the future, and an explanatory text intended to strengthen the perception that life planning is both meaningful and achievable (to target coping appraisal). Following the intervention, participants demonstrated increased emphasis on life planning, stronger behavioral intentions regarding life planning, and greater hope for the future. Additionally, levels of ageism and aging anxiety significantly decreased. Given its effectiveness in enhancing a wide range of psychological and attitudinal outcomes, this intervention shows strong potential for implementation in educational settings targeting younger populations.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of non-exercise physical activity with sarcopenia compared with that of exercise habits among community-dwelling older adults: A 7-year follow-up from the Kashiwa Cohort Study","authors":"Weida Lyu ,&nbsp;Tomoki Tanaka ,&nbsp;Bo-Kyung Son ,&nbsp;Yasuyo Yoshizawa ,&nbsp;Katsuya Iijima","doi":"10.1016/j.aggp.2025.100188","DOIUrl":"10.1016/j.aggp.2025.100188","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigated the relationship of moderate-to-vigorous-intensity non-exercise physical activity (NEPA) and exercise habits (EH) with sarcopenia in community-dwelling older adults.</div></div><div><h3>Methods</h3><div>A 7-year longitudinal analysis was conducted using data of 863 older adults from the Kashiwa Cohort Study in Japan, with baseline assessment in 2014 and follow-up in 2016, 2018, and 2021. Sarcopenia was assessed using the Asian Working Group for Sarcopenia 2019 criteria. NEPA status and EH were evaluated using the Global Physical Activity Questionnaire and a self-reported questionnaire according to the Japanese National Health and Nutrition Survey, respectively.</div></div><div><h3>Results</h3><div>Cox regression analysis identified baseline NEPA and EH as predictors of cumulative sarcopenia incidence. The incidence of new-onset sarcopenia and adjusted hazard ratios (95 % confidence interval [CI]) were 10.7 % and 0.49 (0.25–0.94) for NEPA only, 9.6 % and 0.44 (0.23–0.85) for EH only, and 8.0 % and 0.40 (0.22–0.72) for both, respectively, compared with 18.9 % for the neither NEPA nor EH group. Generalized estimating equations (GEE) analysis revealed that the odds of sarcopenia were significantly lower in the NEPA only, EH only, and both NEPA and EH groups, with adjusted odds ratios (95 % CI) of 0.52 (0.28–0.96), 0.48 (0.24–0.95), and 0.36 (0.20–0.63), respectively.</div></div><div><h3>Conclusions</h3><div>Both NEPA and EH were independently associated with a lower sarcopenia incidence. Therefore, NEPA may be a practical alternative to structured exercises for older adults.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing frailty and functional decline assessment","authors":"Liang-Kung Chen MD, PhD","doi":"10.1016/j.aggp.2025.100190","DOIUrl":"10.1016/j.aggp.2025.100190","url":null,"abstract":"","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining early adversities, demographic, health and psychosocial factors associated with lifetime depression among older Canadians: Findings from a nationally representative study","authors":"Megha Goel ,&nbsp;Esme Fuller-Thomson","doi":"10.1016/j.aggp.2025.100187","DOIUrl":"10.1016/j.aggp.2025.100187","url":null,"abstract":"<div><h3>Purpose</h3><div>Depression among older adults is associated with greater negative physical health, social, and economic outcomes than in younger populations. The objective of this study was to examine factors associated with lifetime depression in a nationally representative sample of Canadian older adults, highlighting characteristics linked to both vulnerability and resilience.</div></div><div><h3>Methods</h3><div>Secondary analysis of the 2022 Mental Health Access to Care Survey (MHACS) was conducted to estimate the prevalence and factors associated with lifetime depression among adults aged 55 and older (<em>n</em> = 3,535). The MHACS measured depression using the World Health Organization’s Composite International Diagnostic Interview (WHO-CIDI). Multivariable logistic regression of lifetime depression was conducted analyzing demographic and socioeconomic variables, adverse childhood experiences, physical health measures, health behaviors, and protective psychosocial factors.</div></div><div><h3>Results</h3><div>One in eleven older adults (9.2%) had experienced depression at some point in their lives. Middle-aged adults (55–64 years) compared to older respondents, and females compared to males had twice the odds of lifetime depression. Other factors associated with depression included childhood physical or sexual abuse, higher educational attainment, history of substance use disorders, multiple chronic physical health conditions, lower sense of life meaning, and higher spirituality.</div></div><div><h3>Conclusion</h3><div>Lifetime depression in older adults is associated with a complex interplay of risk and protective factors. Identifying these factors can support early recognition and targeted intervention, potentially improving outcomes and quality of life in this population.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in risk factors associated with Alzheimer’s dementia patients with irritability and anger","authors":"Philip Cole Brewer ,&nbsp;Timi Kehinde Ojo ,&nbsp;Killian Joseph Bucci ,&nbsp;Connor John O-Brien ,&nbsp;Dami Taiwo Ojo ,&nbsp;Emmanuel I. Nathaniel ,&nbsp;Nathan Gerhard Faulstich ,&nbsp;Adebobola Imeh-Nathaniel ,&nbsp;Richard Goodwin ,&nbsp;Thomas I Nathaniel","doi":"10.1016/j.aggp.2025.100184","DOIUrl":"10.1016/j.aggp.2025.100184","url":null,"abstract":"<div><h3>Background</h3><div>The objective of this study is to identify risk factors that contribute to sex differences in Alzheimer dementia (AD) patients that also present with irritability and anger (ADIA) and determine whether these factors are different between male and female patients with ADIA.</div></div><div><h3>Method</h3><div>We used data from the of database for AD with a history of irritability and collected from a large academic center from 2016 to 2020. A total of 128,769 patients with AD were identified: 72,896 females and 55,873 males. Univariate was used to stratified risk factors base on sex and presence or absence of anger and irritability among AD patients. The adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) for each risk factor or demographic were used to predict the odds of a specific risk factors being associated with male or female ADIA.</div></div><div><h3>Result</h3><div>In the adjusted analysis, male ADIA patients were more likely to present with hypertension (OR = 2.894, 95 % CI, 2.079–4.028), insomnia (OR = 1.736, 95 % CI, 1.132–2.663), dyslipidemia (OR = 1.974, 95 % CI, 1.119–3.482), and peripheral vascular disease (OR = 44.135, 95 % CI, 4.344–448.364). Females were more likely to present with osteoporosis (OR = 0.002, 95 % CI, 0.001–0.023), gait dysfunction (OR = 0.034, 95 % CI, 0.003–0.452), anxiety (OR = 0.634, 95 % CI, 0.472–0.852), urinary tract infection (OR = 0.157, 95 % CI, 0.063–0.393), headaches (OR = 0.121, 95 % CI, 0.052–0.282) and pneumonia (OR = 0.209, 95 % CI, 0.114–0.384).</div></div><div><h3>Conclusion</h3><div>This study reveals key sex differences in ADIA patients. A population-based approach that tackles inequalities in risk factors may offer population-based healthcare and care of male and female ADIA patients.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung ultrasound (LUS) as a predictor of delirium in elderly patients with COVID-19 during hospitalization: A geriatric vulnerability-stress model","authors":"Thomas Fraccalini MD ,&nbsp;Isa Rita Bergoglio MD, PhD ,&nbsp;Gianfranco Fonte MD, PhD ,&nbsp;Andrea Trogolo MD ,&nbsp;Alessandro Maraschi MD ,&nbsp;Thomas Roberts ,&nbsp;Beatrice Tarozzo PsyD ,&nbsp;Beatriz Vitorino MS ,&nbsp;Julia Michelin Vecchini MS ,&nbsp;Santoro Mariangela MD ,&nbsp;Monica Traversa MD, PhD ,&nbsp;Teresa Crea MD ,&nbsp;Luciano Cardinale MD, PhD ,&nbsp;Giuseppe Maina MD ,&nbsp;Valerio Ricci MD, PhD ,&nbsp;Elisa Binello CNO ,&nbsp;Reald Turja NU ,&nbsp;Federico Mallamaci NU ,&nbsp;Giovanni Volpicelli MD","doi":"10.1016/j.aggp.2025.100186","DOIUrl":"10.1016/j.aggp.2025.100186","url":null,"abstract":"<div><h3>Introduction</h3><div>Delirium, an acute confusional state, is common in elderly hospitalized COVID-19 patients and is linked to poor outcomes. Despite this, underdiagnosis persists due to symptom overlap with dementia. This study investigates whether lung ultrasound (LUS) and cognitive screening can predict delirium risk in elderly COVID-19 patients.</div></div><div><h3>Methods</h3><div>A prospective study at San Luigi Hospital enrolled 64 COVID-19 patients (mean age 82.6). Pulmonary involvement was assessed using the LUS Extension Score (LUSext), while cognition was evaluated via MMSE and 4AT tests. Clinical data, including comorbidities and inflammatory markers, were analyzed. ROC curves and multivariate regression identified delirium predictors.</div></div><div><h3>Results</h3><div>Delirium occurred in 61.4 % (35/57). Univariate analysis linked delirium to pre-existing dementia (<em>p</em> = 0.03), higher LUS scores (<em>p</em> = 0.004), and lower MMSE scores (<em>p</em> = 0.0002). A LUS score &gt;3 (sensitivity 74 %, specificity 82 %) best predicted delirium. Multivariate analysis confirmed LUS &gt;3 (OR=4.22, <em>p</em> = 0.023) and lower MMSE (OR=0.87, <em>p</em> = 0.007) as independent risk factors.</div></div><div><h3>Discussion</h3><div>LUS and cognitive impairment are strong predictors of delirium in elderly COVID-19 patients. The LUSext score provides an objective, rapid bedside measure of lung pathology severity, with a score &gt;3 indicating significantly elevated delirium risk. The link between low MMSE and delirium underscores cognitive vulnerability.</div></div><div><h3>Conclusion</h3><div>While delirium is multifactorial, integrating LUS into routine assessment may improve early detection and management in resource-limited settings, effectively identifying high-risk patients using an accessible bedside investigation. A LUS score &gt;3 and low MMSE should prompt preventive measures. Further studies should validate these findings and explore pathophysiology.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}