Archives of Gerontology and Geriatrics Plus最新文献_第6页

Examining rural-urban differences in pain-depression comorbidity and its association with elder abuse: Multivariable decomposition analysis of nationally representative cross-sectional survey 研究城乡间疼痛抑郁共病的差异及其与虐待老人的关系：全国代表性横断面调查的多变量分解分析

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1016/j.aggp.2025.100204

Hemant Singh Gurjar , Anita Mehta

Background

This study investigates rural–urban differences in Pain-Depression Comorbidity (PDC) and its association with elder abuse among older adults in India. It aims to identify the socio-demographic, functional and behavioural health predictors contributing to PDC and elder abuse.

Data and methods

Data were drawn from LASI, 2017–18 survey, comprising 30,772 individuals aged 60+. Pain, depressive symptoms (CES-D-10) and elder abuse were defined based on self-reported data. Covariates on socio-demographic, functional and behavioural health were included. Descriptive statistics, chi-square tests, nested-multilevel logistic-regression models and multivariable-decomposition analysis were used to quantify rural–urban disparities in PDC.

Results

The prevalence of PDC was higher among rural older adults (15 %) compared to their urban counterparts (11 %). A significant association between elder abuse and PDC was observed in both rural and urban areas. The odds of experiencing PDC were significantly higher among individuals reporting elder abuse, with a stronger association in urban areas (AOR = 2.53) than in rural areas (AOR = 1.78). Decomposition analysis shows that 66 % of the rural–urban gap in PDC was attributed to differences in observed characteristics, particularly education, caste, functional health, living arrangement and elder abuse.

Conclusion

This study offers important insights into the interrelationship between elder abuse and PDC in India, revealing substantial rural–urban disparities. The findings highlight the urgent need for residence-specific public health strategies to address the dual burden of pain and depression among older adults. Targeted interventions, especially in rural areas, should focus on education, functional-health and the prevention of elder abuse.

本研究调查了印度老年人疼痛-抑郁共病（PDC）的城乡差异及其与虐待老人的关系。其目的是查明导致PDC和虐待老年人的社会人口、功能和行为健康预测因素。数据和方法数据来自LASI， 2017-18年的调查，包括30,772名60岁以上的人。疼痛、抑郁症状（CES-D-10）和虐待老人的定义基于自我报告的数据。包括社会人口、功能和行为健康方面的协变量。采用描述性统计、卡方检验、嵌套多水平logistic回归模型和多变量分解分析等方法对城乡差异进行量化。结果农村老年人PDC患病率（15%）高于城市老年人（11%）。在农村和城市地区都观察到老年人虐待与PDC之间的显著关联。在报告虐待老年人的个体中，经历PDC的几率明显更高，城市地区（AOR = 2.53）比农村地区（AOR = 1.78）的相关性更强。分解分析表明，城乡差距中66%归因于观察到的特征差异，特别是教育、种姓、功能性健康、生活安排和虐待老人。结论本研究对印度老年人虐待与PDC之间的相互关系提供了重要的见解，揭示了城乡之间存在的巨大差异。研究结果强调，迫切需要针对老年人疼痛和抑郁的双重负担制定具体的公共卫生策略。有针对性的干预措施，特别是在农村地区，应侧重于教育、功能保健和防止虐待老年人。

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引用次数: 0

Personalized multi-modal interfaces for cognitive aging: A narrative review of design and technological innovations 认知老化的个性化多模态界面：设计和技术创新的叙述回顾

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-09-05 DOI: 10.1016/j.aggp.2025.100206

Riya Bhattacharya , Debajyoti Bose , Raul V. Rodriguez , Hemachandran K , Kashif R. Siddique

This narrative review examines the design and execution of adaptive multi-modal interfaces aimed at improving autonomy and cognitive health in aging populations. This is a pressing necessity as the worldwide demographic of those aged 65 and older is anticipated to exceed 1.5 billion by 2050. By incorporating modalities like as speech, touch, gesture, and haptic feedback, these interfaces adaptively customize interactions to accommodate age-related sensory, motor, and cognitive impairments. This review integrates interdisciplinary literature from human-computer interaction, gerontology, and artificial intelligence, synthesizing evidence on cognitive and functional requirements, user-centred design principles, and enabling technologies such as wearable sensors and AI-driven predictive models. This demonstrates 95 % accuracy in predicting user preferences. It emphasizes that tailored interfaces enhance usability by 30 % for older adults and facilitate independent living, especially for individuals with mild cognitive impairment. This evaluation is presented due to the increasing demand for accessible technologies that address accessibility disparities and foster equitable cognitive engagement among various aging demographics. Additionally, this work also identifies research gaps, including the necessity for longitudinal studies and unbiased algorithms, thereby offering a thorough framework for advancements in adaptive systems. It underscores ethical considerations such as data privacy and cultural sensitivity to promote inclusive design.

本文回顾了自适应多模态界面的设计和执行，旨在提高老年人的自主性和认知健康。这是一项迫切的需要，因为到2050年，全球65岁及以上人口预计将超过15亿。通过结合语言、触摸、手势和触觉反馈等方式，这些界面可以自适应地定制交互，以适应与年龄相关的感觉、运动和认知障碍。本综述整合了来自人机交互、老年学和人工智能的跨学科文献，综合了关于认知和功能需求、以用户为中心的设计原则以及可穿戴传感器和人工智能驱动的预测模型等使能技术的证据。这表明预测用户偏好的准确率为95%。它强调量身定制的界面将老年人的可用性提高了30%，并促进了独立生活，特别是对于患有轻度认知障碍的个人。这项评估是由于对无障碍技术的需求不断增加，这些技术可以解决各种老龄化人口之间的无障碍差异并促进公平的认知参与。此外，这项工作还确定了研究差距，包括纵向研究和无偏算法的必要性，从而为自适应系统的进步提供了一个全面的框架。它强调了数据隐私和文化敏感性等伦理考虑，以促进包容性设计。

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引用次数: 0

Caregiver burden, job stress, and coping strategies in work–family conflict among sandwiched caregivers in long-term care settings: A cross-sectional study 长期照护中夹在中间的照护者负担、工作压力和工作家庭冲突的应对策略：一项横断面研究

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1016/j.aggp.2025.100208

Ayumi Honda Ph.D.

Background

Longer life expectancy, along with the delay of marriage and childbearing, has led to an increase in the number of sandwiched caregivers. Employees who are responsible for both childcare and eldercare are more likely to experience work- and caregiving-related stress, which can result in work–family conflict. However, sandwiched caregivers who adopt caregiving-related coping strategies may experience lower conflict between work and family. This exploratory study aimed to investigate the associations of caregiver burden, job stress, and coping strategies with work–family conflict among sandwiched caregivers, and to examine whether caregiving-related coping strategies are associated with lower such conflict.

Methods

This cross-sectional study was conducted using a self-administered questionnaire. The study participants were 72 sandwiched caregivers working in long-term care settings in Japan. All participants had at least one parent aged 65 years or older and were rearing at least one child younger than 18 years. Simple linear regression analysis was performed to assess the associations of work-to-family and family-to-work conflict with caregiver characteristics, caregiving tasks, caregiver burden, job stress, and caregiving-related coping strategies.

Results

Greater caregiver burden and job overload were both commonly associated with work-to-family and family-to-work conflict. In addition, having caregiving-related strategies and behaviors in seeking assistance from others was associated with lower work-to-family conflict.

Conclusion

Individual coping strategies alone may not be sufficient to promote caregiver well-being. Therefore, maintaining social connections for formal and informal support, as well as implementing flextime or providing a flexible workplace for family-supportive practices, may also be necessary.

预期寿命的延长，加上结婚和生育年龄的推迟，导致了夹在中间的照顾者数量的增加。既要照顾孩子又要照顾老人的员工更有可能经历与工作和照顾相关的压力，这可能导致工作与家庭的冲突。然而，采用与照顾相关的应对策略的夹在中间的照顾者可能会减少工作和家庭之间的冲突。本研究旨在探讨夹在三明治中的照顾者负担、工作压力和应对策略与工作家庭冲突的关系，并探讨与照顾相关的应对策略是否与降低工作家庭冲突有关。方法采用自填问卷进行横断面研究。这项研究的参与者是72名在日本长期护理机构工作的夹在三明治里的护理人员。所有参与者的父母中至少有一位年龄在65岁或以上，并且至少有一个年龄在18岁以下的孩子。采用简单线性回归分析评估工作与家庭、家庭与工作冲突与照顾者特征、照顾任务、照顾者负担、工作压力和照顾相关应对策略的关系。结果较大的照顾者负担和工作负荷通常与工作与家庭冲突和家庭与工作冲突有关。此外，在寻求他人帮助时拥有与照顾相关的策略和行为与较低的工作-家庭冲突有关。结论单独的个人应对策略可能不足以提高照顾者的幸福感。因此，维持正式和非正式支持的社会联系，以及实施弹性工作时间或为支持家庭的做法提供灵活的工作场所，可能也是必要的。

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引用次数: 0

Restrictions in community-based care services and the effect on family caregivers during the COVID-19 pandemic: A mixed-methods study COVID-19大流行期间社区护理服务的限制及其对家庭照顾者的影响：一项混合方法研究

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-09-05 DOI: 10.1016/j.aggp.2025.100205

Ayumi Honda Ph.D. , Yin Liu Ph.D. , Mayo Ono Ph.D , Takahiro Nishida R.N , Tatsuya Tsukigi , Elizabeth B. Fauth Ph.D. , Sumihisa Honda Ph.D.

Background

This mixed-methods study aimed to examine the effects of restrictions in the utilization of community-based care services on family caregivers during the COVID-19 pandemic.

Methods

We recruited from community-based care services 200 family caregivers who were living with an older care recipient. We first conducted thematic analyses based on open-ended responses to questions regarding the impact of restrictions in the utilization of community-based care services. We then extracted themes to examine and determine patterns across caregiving characteristics. Next, we conducted linear regression analysis to examine associations between impact of restrictions and caregiving contexts.

Results

We identified 11 themes regarding the impact of restrictions in the utilization of community-based care services. Most frequently reported impact included “the family caregiver cannot bathe the older person at home” and that “the family caregiver cannot go to work/income decreases”. Caregiver employment, more caregiving tasks, and more behavioral and psychological symptoms of dementia of the care recipient were associated with harmful impacts resulting from restrictions in the utilization of community-based care services.

Conclusion

During the COVID-19 pandemic, family caregivers sometimes felt ill equipped to provide home care. Caregiver employment, more caregiving tasks, and more BPSD were factors associated with the negative impact from restricted community-based care service use.

本混合方法研究旨在研究COVID-19大流行期间限制社区护理服务利用对家庭照顾者的影响。方法：我们从社区护理服务机构招募了200名与老年人一起生活的家庭护理人员。我们首先进行了专题分析，基于对有关限制对利用社区护理服务的影响的问题的开放式回答。然后，我们提取主题来检查和确定护理特征的模式。接下来，我们进行了线性回归分析，以检验限制的影响与护理环境之间的关系。结果：我们确定了11个主题，关于限制对社区护理服务利用的影响。最常见的影响包括“家庭照顾者不能在家为老年人洗澡”和“家庭照顾者不能去上班/收入减少”。护理人员就业、更多的护理任务以及更多的护理接受者的行为和心理痴呆症状与限制使用社区护理服务造成的有害影响有关。结论在2019冠状病毒病大流行期间，家庭护理人员有时感到不具备提供家庭护理的能力。护理人员就业、更多的护理任务和更多的BPSD是限制社区护理服务使用的负面影响相关因素。

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引用次数: 0

Auditory-cognitive markers of mild cognitive impairment: Evidence from a systematic review 轻度认知障碍的听觉认知标志：来自系统评价的证据

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-11-17 DOI: 10.1016/j.aggp.2025.100231

Neelesh Benet, Vijay Kumar, Srikar Vijayasarthy

Introduction

Mild Cognitive Impairment (MCI) represents an intermediate stage between normal aging and dementia. Emerging evidence suggests that central auditory processing (CAP) deficits may appear even earlier and serve as sensitive indicators of cognitive decline.

Objective

The literature was reviewed to examine the CAP abilities in individuals with MCI. It also examines existing MCI diagnostic guidelines from various countries to assess how CAP assessments are currently integrated in clinical protocols.

Method

A systematic literature search was conducted using PubMed/Medline, Cochrane Library, Scopus and Google Scholar (Jan 2014–Dec 2024). Key search terms included “temporal resolution,” “dichotic,” “speech-in-noise,” “auditory working memory,” “central auditory processing disorder,” “auditory scene analysis,” “temporal gap detection,” “auditory discrimination,” and “mild cognitive impairment.” Only those studies were shortlisted if they investigated CAP in elderly individuals with MCI. Articles outlining MCI diagnostic guidelines were also considered.

Result

Twenty-nine articles met the inclusion criteria. Twenty-three indicated a significant CAP deficit in persons with MCI. Studies consistently show MCI is associated with CAP impairments. Tests like Gap Detection Threshold, Dichotic Digit Test, Sentence-in-Noise, and Digits Backward effectively distinguish MCI patients from healthy controls. Six articles focused on diagnostic guidelines from various countries. Despite many studies showing CAP deficits in MCI, leading diagnostic guidelines do not include CAP tests.

Conclusion

CAP tests hold promise for the early detection of MCI. Integrating them into clinical guidelines can improve diagnostic sensitivity which may delay its progression to Alzheimer’s disease. Despite their diagnostic utility, such tests are not included in the MCI diagnostic frameworks.

轻度认知障碍（MCI）是介于正常衰老和痴呆之间的中间阶段。新出现的证据表明，中枢听觉处理（CAP）缺陷可能出现得更早，并作为认知能力下降的敏感指标。目的回顾相关文献，探讨MCI患者的CAP能力。它还审查了各国现有的MCI诊断指南，以评估目前如何将CAP评估纳入临床方案。方法系统检索PubMed/Medline、Cochrane Library、Scopus和谷歌Scholar（2014年1月- 2024年12月）的文献。关键搜索词包括“时间分辨”、“二分法”、“噪音中的言语”、“听觉工作记忆”、“中央听觉处理障碍”、“听觉场景分析”、“时间间隙检测”、“听觉辨别”和“轻度认知障碍”。只有那些调查老年轻度认知障碍患者CAP的研究被列入候选名单。还考虑了概述MCI诊断指南的文章。结果29篇文章符合纳入标准。23例轻度认知障碍患者CAP显著缺失。研究一致表明，轻度认知障碍与CAP损伤有关。间隙检测阈值、二分数字测试、噪声句子、数字倒向等测试可以有效区分轻度认知障碍患者和健康对照组。六篇文章重点介绍了各国的诊断指南。尽管许多研究表明轻度认知损伤存在CAP缺陷，但主流诊断指南并未包括CAP测试。结论cap检测对早期发现轻度认知损伤具有重要意义。将它们纳入临床指南可以提高诊断敏感性，从而可能延缓其向阿尔茨海默病的发展。尽管这些测试具有诊断功能，但它们并未包括在MCI诊断框架中。

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引用次数: 0

Healthcare service utilization and treatment costs among elderly citizens in Bangladesh 孟加拉国老年公民的医疗保健服务利用和治疗费用

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-10-08 DOI: 10.1016/j.aggp.2025.100218

Abdur Razzaque Sarker

Bangladesh’s population is aging rapidly, with 8 % of the population currently aged 60 or older, projected to reach 21.5 million by 2030. Elderly citizens face significant health challenges and healthcare costs, increasing demands on the healthcare system. This study assessed self-reported illnesses, treatment costs, and factors influencing healthcare utilization among the elderly in Bangladesh. A cross-sectional survey of 585 elderly citizens (aged 60+ as per Bangladesh’s National Policy on Elderly People) was conducted in Tangail district from December 2019 to February 2020. Descriptive statistics and logistic regression analysis were used to analyze factors associated with healthcare utilization. We found about 92 % of elderly respondents reported illness, with hypertension, ulcers, pain, and diabetes being most common. Average treatment cost per case was BDT 7714 (SD ± 32,472; Median: 1809; IQR: 4926), with medicine as the largest cost driver. Factors such as education, marital status, residence, and wealth were significantly associated with healthcare utilization. These findings provide valuable baseline health data for elderly citizens and can guide policymakers in designing appropriate disease control strategies to improve their health outcomes. Financial risk protection mechanisms, such as the introduction of social health insurance, should be considered to ensure healthcare is both affordable and accessible for all elderly citizens.

孟加拉国的人口正在迅速老龄化，目前有8%的人口年龄在60岁或以上，预计到2030年将达到2150万。老年人面临着重大的健康挑战和医疗保健费用，增加了对医疗保健系统的需求。本研究评估了孟加拉国老年人自我报告的疾病、治疗费用和影响医疗保健利用的因素。2019年12月至2020年2月，在坦盖尔区对585名老年人（根据孟加拉国国家老年人政策，年龄在60岁以上）进行了横断面调查。采用描述性统计和逻辑回归分析分析与医疗保健利用相关的因素。我们发现大约92%的老年受访者报告了疾病，其中高血压、溃疡、疼痛和糖尿病最为常见。每例患者的平均治疗费用为7714 BDT (SD±32472；中位数：1809；IQR: 4926)，其中药物是最大的成本驱动因素。教育、婚姻状况、居住地和财富等因素与医疗保健利用显著相关。这些发现为老年公民提供了有价值的基线健康数据，可以指导决策者设计适当的疾病控制策略，以改善他们的健康结果。应考虑引入社会健康保险等财务风险保护机制，以确保所有老年公民都能负担得起并获得医疗保健。

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引用次数: 0

Association between IL-17 and sarcopenia in older adults IL-17与老年人肌肉减少症的关系

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-08-20 DOI: 10.1016/j.aggp.2025.100200

Everson de Cássio Robello , Gabriela Cabett Cipolli , Natália Almeida Lima , Isabela Fernandes Nonato , Mônica Sanches Yassuda , Danillo Magalhães Xavier Assunção , Ronei Luciano Mamoni , Andréia de Oliveira Pain , Ana Maria Kemp , Richard C. Oude Voshaar , Gustavo Duque , Ivan Aprahamian

Background

Chronic low-grade inflammation has been implicated as a potential contributor to sarcopenia, but the specific inflammatory mediators involved remain under investigation. This study explores the association between serum interleukin-17 levels and sarcopenia in older outpatients without pre-existing inflammatory or autoimmune diseases.

Methods

A cross-sectional study was conducted using data from the MiMiCS-FRAIL cohort. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People 2 criteria. IL-17 plasma levels were measured using enzyme-linked immunosorbent assay (ELISA). A multivariate binary logistic regression model was used to assess the association between sarcopenia and IL-17 levels.

Results

A total of 255 older adults aged ≥60 years (67.6 % women) were included, with a mean age of 70.8 ± 7.3 years. The prevalence of sarcopenia was 16.9 %. Advanced age (OR = 4.26; 95 % CI: 1.75–10.41; p = 0.001) was significantly associated with sarcopenia. In the fully adjusted model, IL-17 (log-transformed) remained significantly associated with sarcopenia (OR = 1.74; 95 % CI: 1.11–2.74; p = 0.017). Age (OR = 1.10; 95 % CI: 1.03–1.17; p = 0.003) and BMI (OR = 0.69; 95 % CI: 0.60–0.79; p < 0.001) were also associated. IL-6, TNF-α, number of medications, sex, and cognitive score were not statistically significant.

Conclusions

Elevated IL-17 levels were associated with higher odds of sarcopenia among older adults. These findings suggest that IL-17 may serve as a potential biomarker for sarcopenia, although further longitudinal studies are needed to elucidate its causal role.

慢性低度炎症已被认为是肌肉减少症的潜在诱因，但具体的炎症介质仍在研究中。本研究探讨无炎症或自身免疫性疾病的老年门诊患者血清白细胞介素-17水平与肌肉减少症之间的关系。方法采用来自mimics -虚弱队列的数据进行横断面研究。肌少症的定义是根据欧洲老年人肌少症工作组2的标准。采用酶联免疫吸附试验（ELISA）测定血浆IL-17水平。采用多元二元logistic回归模型评估肌肉减少症与IL-17水平之间的关系。结果共纳入255例60岁以上老年人，其中女性占67.6%，平均年龄70.8±7.3岁。肌肉减少症患病率为16.9%。高龄（OR = 4.26; 95% CI: 1.75-10.41; p = 0.001）与肌肉减少症显著相关。在完全调整的模型中，IL-17（对数转换）仍然与肌肉减少症显著相关（OR = 1.74; 95% CI: 1.11-2.74; p = 0.017）。年龄（OR = 1.10; 95% CI: 1.03-1.17; p = 0.003）和BMI （OR = 0.69; 95% CI: 0.60-0.79; p < 0.001）也相关。IL-6、TNF-α、用药次数、性别、认知评分差异无统计学意义。结论IL-17水平升高与老年人肌肉减少症的发生率增高有关。这些发现表明IL-17可能作为肌肉减少症的潜在生物标志物，尽管需要进一步的纵向研究来阐明其因果作用。

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引用次数: 0

Classificating middle-aged and older adults through physiological and functional measures 通过生理和功能指标对中老年人群进行分类

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-09-29 DOI: 10.1016/j.aggp.2025.100212

Veysel Alcan Ph.D

Aging affects the functional capacity of individuals by causing gradual changes in metabolic, gait, balance and muscle functions. Identifying these changes between middle-aged (45–64) and older (≥65) adults is critical to understanding the biological and functional effects of aging. This study aims to evaluate the differences between middle-aged and older adults in an objective and scalable manner by analyzing metabolic indicators, gait parameters, balance measurements and muscle functions using machine learning (ML) methods. In this study, 57 high-dimensional variables from the MIDUS dataset including gait parameters (e.g. gait speed, cadence, cycle time), muscle function, balance measurements (e.g. path length, swing area), bone mineral density and bioelectrical impedance spectroscopy markers were used. Supervised ML models were applied to classify the age groups: Partial Least Squares Discriminant Analysis (PLS-DA), Principal Component Analysis-Linear Discriminant Analysis (PCA-LDA), Support Vector Machine (SVM), and k-Nearest Neighbors (k-NN). Venetian blind cross-validation approach was applied to evaluate the model performance. Among the models, SVM showed the highest classification accuracy (87 %) on the training data and 77 % accuracy on the testing data. PLS-DA model achieved 82 % accuracy in training and 86 % in testing. While k-NN model showed 87 % accuracy in training, it dropped to 68 % in testing. In terms of sensitivity and specificity values, SVM showed the best performance (96 % sensitivity, 67 % specificity - training; 86 % sensitivity, 55 % specificity - test), while PLS-DA and PCA-LDA models exhibited similar trends. The results show that walking speed, cadence, and balance measurements provide significant contributions to age group discrimination. These findings highlight the role of neuromuscular and physiological factors in functional decline due to aging, demonstrating the potential of machine learning-based classification in aging research.

衰老通过引起代谢、步态、平衡和肌肉功能的逐渐变化来影响个体的功能能力。确定中年（45-64岁）和老年人（≥65岁）之间的这些变化对于理解衰老的生物学和功能效应至关重要。本研究旨在通过使用机器学习（ML）方法分析代谢指标、步态参数、平衡测量和肌肉功能，以客观和可扩展的方式评估中老年人之间的差异。在这项研究中，使用了MIDUS数据集中的57个高维变量，包括步态参数（如步态速度、节奏、周期时间）、肌肉功能、平衡测量（如路径长度、摆动面积）、骨矿物质密度和生物电阻抗谱标记。使用监督ML模型对年龄组进行分类：偏最小二乘判别分析（PLS-DA）、主成分分析-线性判别分析（PCA-LDA）、支持向量机（SVM）和k-近邻（k-NN）。采用威尼斯盲交叉验证法评价模型的性能。其中SVM对训练数据的分类准确率最高（87%），对测试数据的分类准确率最高（77%）。PLS-DA模型的训练准确率为82%，测试准确率为86%。虽然k-NN模型在训练中显示出87%的准确率，但在测试中下降到68%。在敏感性和特异性值方面，SVM表现最佳（96%的敏感性，67%的特异性-训练；86%的敏感性，55%的特异性-测试），而PLS-DA和PCA-LDA模型表现出类似的趋势。结果表明，步行速度、节奏和平衡测量对年龄组歧视有显著贡献。这些发现突出了神经肌肉和生理因素在衰老导致的功能衰退中的作用，展示了基于机器学习的分类在衰老研究中的潜力。

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引用次数: 0

Corrigendum to “Restrictions in community-based care services and the effect on family caregivers during the COVID-19 pandemic: A mixed-methods study” [Archives of Gerontology and Geriatrics Plus, Volume 2, Issue 4 (2025), Article 100205] “COVID-19大流行期间社区护理服务的限制及其对家庭照顾者的影响：一项混合方法研究”的勘误表[老年病学档案+，第2卷，第4期（2025），第100205条]

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI: 10.1016/j.aggp.2025.100210

Ayumi Honda , Yin Liu , Mayo Ono , Takahiro Nishida , Tatsuya Tsukigi , Elizabeth B. Fauth , Sumihisa Honda

引用次数: 0

Trends in chronic kidney disease-related mortality among older adults in the United States from 1999-2020 1999-2020年美国老年人慢性肾脏疾病相关死亡率趋势

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1016/j.aggp.2025.100161

Hamza Ehtesham , Ahmed Kamal Siddiqi , Marium Omair Mirza , Mushtaq Ahmad , Rija Shakil

Background

With increasing age in the United States, the disease burden of chronic kidney disease (CKD) has increased. The CKD-related mortality trends have not been explored for individuals aged ≥ 65 years. The aim of the study was to identify and evaluate the trends in sex, race, and region among CKD-related mortality in older adults.

Methods

Death records sourced from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database were used to analyze mortality trends of CKD in individuals aged ≥65 years from 1999 to 2020. We computed age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent changes (APC) using Joinpoint software. The analysis was structured according to year, sex, race/ethnicity, and geographical regions.

Results

From 1999 to 2020, there were 1,572,057 CKD-related deaths. The age-adjusted mortality rate (AAMR) rose from 1999 to 2005, declined until 2009, surged from 2009 to 2012, fell in 2015, and increased again in 2020. Men had a higher AAMR (225) than women (136.3). Non-Hispanic Black or African Americans experienced the highest AAMR (319.2), followed by NH American Indian or Alaska Native (229.5), Hispanic (178.5), NH white (154.5), and NH Asian or Pacific Islander (144.1). Regionally, AAMR was highest in the Midwest (184.6) and lower in non-metropolitan areas (133.3) compared to metropolitan areas (126.3).

Conclusion

CKD-related mortality is rising among U.S. adults ≥ 65, especially in non-Hispanic African American males in the Midwest and rural areas. Screening high-risk individuals can enable early detection and lower mortality rates.

在美国，随着年龄的增长，慢性肾脏疾病（CKD）的疾病负担也在增加。对于年龄≥65岁的个体，ckd相关的死亡率趋势尚未被探讨。该研究的目的是确定和评估老年人ckd相关死亡率的性别、种族和地区趋势。方法使用来自CDC WONDER（疾病控制和预防中心流行病学研究广泛在线数据）数据库的死亡记录，分析1999年至2020年年龄≥65岁个体CKD的死亡趋势。我们使用Joinpoint软件计算了每10万人的年龄调整死亡率（AAMRs）和年百分比变化（APC）。分析是根据年份、性别、种族/民族和地理区域进行的。结果1999年至2020年，有1,572,057例ckd相关死亡。年龄调整死亡率（AAMR）从1999年到2005年上升，直到2009年下降，从2009年到2012年激增，2015年下降，并在2020年再次上升。男性的AAMR（225）高于女性（136.3）。非西班牙裔黑人或非洲裔美国人的AAMR最高（319.2），其次是NH美洲印第安人或阿拉斯加原住民（229.5），西班牙裔（178.5），NH白人（154.5）和NH亚洲或太平洋岛民（144.1）。从地区来看，中西部地区的AAMR最高（184.6），非首都地区的AAMR较低（133.3），而首都地区为126.3。结论：ckd相关死亡率在美国≥65岁的成年人中呈上升趋势，尤其是中西部和农村地区的非西班牙裔美国男性。对高危人群进行筛查，可以及早发现并降低死亡率。

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