Pub Date : 2024-03-05DOI: 10.1016/j.aggp.2024.100016
Milene Vitória Sampaio Sobral , Victor Gonçalves Soares , Ocilio Ribeiro Gonçalves , Victoria Städler de Abreu , Lucas Cael Azevedo Ramos Bendaham , Brenda Leticia Lopes Batista M.D. , Marco Antonnio Rocha dos Santos M.D., MsC
Introduction
Gantenerumab has garnered considerable attention for its potential to modify the natural course of Alzheimer's disease. However, recent studies have shown mixed results for the use of this medication for the treatment of Alzheimer's Disease. Therefore, this review compared the effects of Gantenerumab with placebo in patients with Alzheimer's disease.
Methods
Literature searches were conducted in PubMed, Embase and Cochrane database from inception to December 2023. Two independent authors (MS and LV) performed the study selection, data extraction and quality assessment. The outcomes of this review were: Clinical Dementia Rating - Sum of Boxes (CDR-SB), the Alzheimer's Disease Assessment Scale (ADAS-Cog), the Mini-Mental State Evaluation (MMSE) and the incidence of Amyloid-Related Imaging Abnormalities with Edema (ARIA-E) or Amyloid-Related Imaging Abnormalities with Hemosiderosis (ARIA-H). Meta-analysis were performed using Review Manager 5.4 (Cochrane Collaboration).
Results
Four studies reporting data for 2,848 patients were included in this review. The lenght of follow-up assessments ranged from 50 to 104 weeks. When compared to placebo, Gantenerumab was significantly associated with a lower ADAS-Cog score (MD -1.05; 95 % CI: -1.85 to -0.25) and lower MMSE score (MD -0.31; 95 % CI: -0.55 to -0.07). There were no differences in the CDR-SB score. Gantenerumab group had a higher incidence of ARIA-E (RR 8.94; 95 % CI: 6.22 to 12.84).
Conclusion
Gantenerumab showed negative effects on cognitive outcomes of people with Alzheimer's Disease. There was a higher incidence of ARIA-E and ARIA-H for gantenerumab. Additional high quality studies are needed to draw more robust conclusions about this treatment.
{"title":"Efficacy and safety of gantenerumab in the treatment of Alzheimer's disease: A meta-analysis of randomized controlled trials","authors":"Milene Vitória Sampaio Sobral , Victor Gonçalves Soares , Ocilio Ribeiro Gonçalves , Victoria Städler de Abreu , Lucas Cael Azevedo Ramos Bendaham , Brenda Leticia Lopes Batista M.D. , Marco Antonnio Rocha dos Santos M.D., MsC","doi":"10.1016/j.aggp.2024.100016","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100016","url":null,"abstract":"<div><h3>Introduction</h3><p>Gantenerumab has garnered considerable attention for its potential to modify the natural course of Alzheimer's disease. However, recent studies have shown mixed results for the use of this medication for the treatment of Alzheimer's Disease. Therefore, this review compared the effects of Gantenerumab with placebo in patients with Alzheimer's disease.</p></div><div><h3>Methods</h3><p>Literature searches were conducted in PubMed, Embase and Cochrane database from inception to December 2023. Two independent authors (MS and LV) performed the study selection, data extraction and quality assessment. The outcomes of this review were: Clinical Dementia Rating - Sum of Boxes (CDR-SB), the Alzheimer's Disease Assessment Scale (ADAS-Cog), the Mini-Mental State Evaluation (MMSE) and the incidence of Amyloid-Related Imaging Abnormalities with Edema (ARIA-E) or Amyloid-Related Imaging Abnormalities with Hemosiderosis (ARIA-H). Meta-analysis were performed using Review Manager 5.4 (Cochrane Collaboration).</p></div><div><h3>Results</h3><p>Four studies reporting data for 2,848 patients were included in this review. The lenght of follow-up assessments ranged from 50 to 104 weeks. When compared to placebo, Gantenerumab was significantly associated with a lower ADAS-Cog score (MD -1.05; 95 % CI: -1.85 to -0.25) and lower MMSE score (MD -0.31; 95 % CI: -0.55 to -0.07). There were no differences in the CDR-SB score. Gantenerumab group had a higher incidence of ARIA-E (RR 8.94; 95 % CI: 6.22 to 12.84).</p></div><div><h3>Conclusion</h3><p>Gantenerumab showed negative effects on cognitive outcomes of people with Alzheimer's Disease. There was a higher incidence of ARIA-E and ARIA-H for gantenerumab. Additional high quality studies are needed to draw more robust conclusions about this treatment.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000134/pdfft?md5=041a56c07fbd77175798d009e4f4f250&pid=1-s2.0-S2950307824000134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140162749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04DOI: 10.1016/j.aggp.2024.100014
Xin-Jie Lim , Kok-Leong Tan , Gaik-Kin Teoh , Maw-Pin Tan
Introduction
Health literacy is crucial in controlling the spread of SARS-CoV2 and preventing infection, as well as preparing healthcare systems for situations that require immediate response. The aim of this study was to evaluate older people's health literacy towards disease prevention, as well as the motivators and barriers they experienced when adopting preventative measures.
Methods
We conducted in-depth interviews with 16 participants aged 65 and beyond. Purposive sampling was used to recruit participants, accounting for variability in gender, age and educational level. The transcripts were analysed using thematic analysis methods. The interview guide was developed using Sørensen's conceptual model of health literacy.
Results
Five main themes and 16 sub-themes were identified in this study. Knowledge and perception on preventive measures (with two sub-themes), sources of Covid-19 information (with two sub-themes), appraise the health information (with two sub-themes), perceived practice (with five sub-themes), barriers and motivators (with five sub-themes) were the major themes. This study discovered aspects of SEM may influence preventive measure adoption and the impact of different levels of SEM on seniors' decision-making for preventive measure adoption.
Conclusion
This study examined older adults' experiences with CoviD-19-related health literacy (access, comprehend, assess, and apply), as well as their preventative behaviours, barriers, and motivators. Future disease outbreak mitigation measures should consider the SEM approach in order to improve health communication and promote healthy behaviour.
引言 健康素养对于控制 SARS-CoV2 的传播、预防感染以及使医疗系统做好准备应对需要立即采取应对措施的情况至关重要。本研究旨在评估老年人对疾病预防的健康素养,以及他们在采取预防措施时遇到的动机和障碍。在招募参与者时,我们采用了有目的的抽样方法,考虑到了性别、年龄和教育水平方面的差异。访谈记录采用主题分析方法进行分析。本研究确定了五个主题和 16 个子主题。对预防措施的了解和看法(两个次主题)、Covid-19 信息的来源(两个次主题)、对健康信息的评价(两个次主题)、实践感知(五个次主题)、障碍和动机(五个次主题)是主要主题。本研究发现了 SEM 的各个方面可能会影响预防措施的采用,以及不同水平的 SEM 对老年人采用预防措施决策的影响。结论本研究考察了老年人在 CoviD-19 相关健康素养(获取、理解、评估和应用)方面的经验,以及他们的预防行为、障碍和动机。未来的疾病爆发缓解措施应考虑采用 SEM 方法,以改善健康传播和促进健康行为。
{"title":"COVID-19 related health literacy and preventive behaviours of the older person in Perak state, Malaysia: A qualitative study","authors":"Xin-Jie Lim , Kok-Leong Tan , Gaik-Kin Teoh , Maw-Pin Tan","doi":"10.1016/j.aggp.2024.100014","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100014","url":null,"abstract":"<div><h3>Introduction</h3><p>Health literacy is crucial in controlling the spread of SARS-CoV2 and preventing infection, as well as preparing healthcare systems for situations that require immediate response. The aim of this study was to evaluate older people's health literacy towards disease prevention, as well as the motivators and barriers they experienced when adopting preventative measures.</p></div><div><h3>Methods</h3><p>We conducted in-depth interviews with 16 participants aged 65 and beyond. Purposive sampling was used to recruit participants, accounting for variability in gender, age and educational level. The transcripts were analysed using thematic analysis methods. The interview guide was developed using Sørensen's conceptual model of health literacy.</p></div><div><h3>Results</h3><p>Five main themes and 16 sub-themes were identified in this study. Knowledge and perception on preventive measures (with two sub-themes), sources of Covid-19 information (with two sub-themes), appraise the health information (with two sub-themes), perceived practice (with five sub-themes), barriers and motivators (with five sub-themes) were the major themes. This study discovered aspects of SEM may influence preventive measure adoption and the impact of different levels of SEM on seniors' decision-making for preventive measure adoption.</p></div><div><h3>Conclusion</h3><p>This study examined older adults' experiences with CoviD-19-related health literacy (access, comprehend, assess, and apply), as well as their preventative behaviours, barriers, and motivators. Future disease outbreak mitigation measures should consider the SEM approach in order to improve health communication and promote healthy behaviour.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000110/pdfft?md5=c98af1c6e3700ada8f0f299ec7d5ed73&pid=1-s2.0-S2950307824000110-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-02DOI: 10.1016/j.aggp.2024.100017
Raphaela V Groehs, Ana Carla Carvalho, Weliton Nepomuceno Rodrigues, Isabela B Oliveira, Leticia Harada, Alexandra Passos Gaspar, Luciana Diniz Nagem Janot de Matos
Background
The aging process affects different systems, including the musculoskeletal and respiratory systems. Both systems seem to be interconnected in relation to functional capacity deterioration in the elderly. Therefore, this study aimed to evaluate the association between peripheral and respiratory muscle strength with gait speed and its possible mediation by leg muscle blood flow (LBF) in the elderly.
Methods
People aged over 65 years, of both sexes and clinically stable were evaluated. Gait speed was evaluated by the 4.6 m walking test. Maximal inspiratory pressure (MIP) and expiratory pressure (MEP) by manuvacuometry, Handgrip strength by a dynamometer (Jamar®) and LBF by venous occlusion plethysmography.
Results
We included 110 patients with mean age 76.9 ± 7.2 years, 56 (50.9 %) were women, 72 (67.9 %) were classified as frail by Fried criteria and 22 (20.0 %) reported the regular practice of exercise. Baseline mean values of MIP was 59.5 ± 23.8 and MEP 68.2 ± 23.8. The median gait speed was 0.88 m/s, handgrip strength 19.5 Kg/f and LBF 2.7 ml/min/100 ml. Further analysis showed a significant association between gait speed and handgrip strength with MIP (p = 0.005, p = 0.013, respectively). However, no mediation by LBF were found.
Conclusion
There is a strong association between gait speed and handgrip strength with MIP without mediation by LBF.
{"title":"Association between peripheral and respiratory muscle strength and gait speed in the elderly is not mediated by peripheral muscle blood flow","authors":"Raphaela V Groehs, Ana Carla Carvalho, Weliton Nepomuceno Rodrigues, Isabela B Oliveira, Leticia Harada, Alexandra Passos Gaspar, Luciana Diniz Nagem Janot de Matos","doi":"10.1016/j.aggp.2024.100017","DOIUrl":"10.1016/j.aggp.2024.100017","url":null,"abstract":"<div><h3>Background</h3><p>The aging process affects different systems, including the musculoskeletal and respiratory systems. Both systems seem to be interconnected in relation to functional capacity deterioration in the elderly. Therefore, this study aimed to evaluate the association between peripheral and respiratory muscle strength with gait speed and its possible mediation by leg muscle blood flow (LBF) in the elderly.</p></div><div><h3>Methods</h3><p>People aged over 65 years, of both sexes and clinically stable were evaluated. Gait speed was evaluated by the 4.6 m walking test. Maximal inspiratory pressure (MIP) and expiratory pressure (MEP) by manuvacuometry, Handgrip strength by a dynamometer (Jamar®) and LBF by venous occlusion plethysmography.</p></div><div><h3>Results</h3><p>We included 110 patients with mean age 76.9 ± 7.2 years, 56 (50.9 %) were women, 72 (67.9 %) were classified as frail by Fried criteria and 22 (20.0 %) reported the regular practice of exercise. Baseline mean values of MIP was 59.5 ± 23.8 and MEP 68.2 ± 23.8. The median gait speed was 0.88 m/s, handgrip strength 19.5 Kg/f and LBF 2.7 ml/min/100 ml. Further analysis showed a significant association between gait speed and handgrip strength with MIP (<em>p</em> = 0.005, <em>p</em> = 0.013, respectively). However, no mediation by LBF were found.</p></div><div><h3>Conclusion</h3><p>There is a strong association between gait speed and handgrip strength with MIP without mediation by LBF.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100017"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000146/pdfft?md5=b2541e5c2627e2a7829c24021bf8968c&pid=1-s2.0-S2950307824000146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-27DOI: 10.1016/j.aggp.2024.100012
David E. Vance , Andres Azuero , Michael Vinikoor , Julie K. Schexnayder , Frank Puga , Benjamin Galatzan , Jun Y. Byun , Chunhong Xiao , Hathaichanok Phaowiriya , Dara L. James , Pariya L. Fazeli
Objective
Cognitive intra-individual variability (IIV), dispersion of cognitive performance across cognitive domains, indicates diminished cognitive control resulting from brain pathology or aging. For people with HIV-Associated Neurocognitive Disorder (HAND), cognitive IIV may interfere with and/or be improved by cognitive training. In this current secondary data analysis, we explored whether cognitive IIV functions as an outcome or moderator variable in speed of processing (SOP) training in middle-aged and older people living with HIV (PLWH).
Method
In this randomized clinical trial, 216 PLWH with HAND or borderline HAND were randomized to either: 1) 10 h of SOP training; 2) 20 h of SOP training, or 3) 10 h of Internet Navigation Control Training. Participants completed a seven-domain cognitive battery at baseline, posttest after training, and years 1 and 2 follow up; from this, the coefficient of variation (CoV) served as the cognitive IIV dispersion score. Participants also completed a gold-standard measure of SOP (i.e., Useful Field of View Test (UFOV®), a targeted cognitive outcomes of the SOP training paradigm) at each time point.
Results
Using linear mixed-effect models, no strong pattern of SOP training effects were detected on cognitive IIV. However, a three-way interaction tests between time, group, and baseline cognitive IIV CoV suggested potential moderation effects. Stratified analyses showed differential treatment effects between the lower cognitive IIV and higher cognitive IIV group.
Conclusions
Although SOP training did not improve cognitive IIV, cognitive IIV may be a modifier of SOP training. Implications for future research and other types of training are provided.
{"title":"Cognitive intra-individual variability as an outcome or moderator of speed of processing training in aging adults with HIV-associated neurocognitive disorder: A secondary data analysis of a 2-year longitudinal randomized clinical trial","authors":"David E. Vance , Andres Azuero , Michael Vinikoor , Julie K. Schexnayder , Frank Puga , Benjamin Galatzan , Jun Y. Byun , Chunhong Xiao , Hathaichanok Phaowiriya , Dara L. James , Pariya L. Fazeli","doi":"10.1016/j.aggp.2024.100012","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100012","url":null,"abstract":"<div><h3>Objective</h3><p>Cognitive intra-individual variability (IIV), dispersion of cognitive performance across cognitive domains, indicates diminished cognitive control resulting from brain pathology or aging. For people with HIV-Associated Neurocognitive Disorder (HAND), cognitive IIV may interfere with and/or be improved by cognitive training. In this current secondary data analysis, we explored whether cognitive IIV functions as an outcome or moderator variable in speed of processing (SOP) training in middle-aged and older people living with HIV (PLWH).</p></div><div><h3>Method</h3><p>In this randomized clinical trial, 216 PLWH with HAND or borderline HAND were randomized to either: 1) 10 h of SOP training; 2) 20 h of SOP training, or 3) 10 h of Internet Navigation Control Training. Participants completed a seven-domain cognitive battery at baseline, posttest after training, and years 1 and 2 follow up; from this, the coefficient of variation (<em>CoV</em>) served as the cognitive IIV dispersion score. Participants also completed a gold-standard measure of SOP (i.e., Useful Field of View Test (UFOV®), a targeted cognitive outcomes of the SOP training paradigm) at each time point.</p></div><div><h3>Results</h3><p>Using linear mixed-effect models, no strong pattern of SOP training effects were detected on cognitive IIV. However, a three-way interaction tests between time, group, and baseline cognitive IIV <em>CoV</em> suggested potential moderation effects. Stratified analyses showed differential treatment effects between the lower cognitive IIV and higher cognitive IIV group.</p></div><div><h3>Conclusions</h3><p>Although SOP training did not improve cognitive IIV, cognitive IIV may be a modifier of SOP training. Implications for future research and other types of training are provided.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100012"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000092/pdfft?md5=19fced63480fc84103593ddec9272764&pid=1-s2.0-S2950307824000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigated the association between depressive symptoms and the instrumental activities of daily living (IADL) decline among physically and socially independent older people according to being employed or participating in social activities in a Japanese age-specific cohort.
Methods
We performed a prospective cohort study including 1,508 (716 men and 792 women) aged 64/65. Depressive symptoms were assessed at baseline (2000–2005). The change in IADL status was ascertained in the secondary survey when the participants reached 70 years of age. Multivariable odds ratios (ORs) and confidence intervals (CIs) of depressive symptoms for IADL decline were calculated using a logistic regression model adjusted for enroll year, sex, employment status, marital status, education, smoking status, alcohol consumption status, body mass index, walking status, daily sleep duration, and medical histories of cancer, cardio-cerebrovascular diseases, hypertension, and diabetes mellitus. We also formally tested for potential interaction effects by employment and participation in social activities.
Results
The OR of the presence of depressive symptoms and not employed was 3.25 (95% CI 1.57–6.75), compared to participants without depressive symptoms and employed, after adjusting for potential confounders. Compared to participants without depressive symptoms and with a high frequency of participation in social activities, participants with depressive symptoms and a low frequency of participation in social activities were associated with IADL decline (OR 2.45; 95% CI 1.23–4.90). However, we observed no evidence of an interaction effect by employment and participation in social activities.
Conclusions
This age-specific cohort study revealed that being employed or participating in social activities may prevent IADL decline among depressed older adults.
{"title":"Associations of depressive symptoms and instrumental activities of daily living decline by employment or participation in social activities among younger-older Japanese in the New Integrated Suburban Seniority Investigation (NISSIN) Project","authors":"Rika Taniguchi , Shigekazu Ukawa , Wenjing Zhao , Satoe Okabayashi , Takashi Kimura , Yifan Shan , Masahiko Ando , Kenji Wakai , Kazuyo Tsushita , Takashi Kawamura , Akiko Tamakoshi","doi":"10.1016/j.aggp.2024.100013","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100013","url":null,"abstract":"<div><h3>Objectives</h3><p>This study investigated the association between depressive symptoms and the instrumental activities of daily living (IADL) decline among physically and socially independent older people according to being employed or participating in social activities in a Japanese age-specific cohort.</p></div><div><h3>Methods</h3><p>We performed a prospective cohort study including 1,508 (716 men and 792 women) aged 64/65. Depressive symptoms were assessed at baseline (2000–2005). The change in IADL status was ascertained in the secondary survey when the participants reached 70 years of age. Multivariable odds ratios (ORs) and confidence intervals (CIs) of depressive symptoms for IADL decline were calculated using a logistic regression model adjusted for enroll year, sex, employment status, marital status, education, smoking status, alcohol consumption status, body mass index, walking status, daily sleep duration, and medical histories of cancer, cardio-cerebrovascular diseases, hypertension, and diabetes mellitus. We also formally tested for potential interaction effects by employment and participation in social activities.</p></div><div><h3>Results</h3><p>The OR of the presence of depressive symptoms and not employed was 3.25 (95% CI 1.57–6.75), compared to participants without depressive symptoms and employed, after adjusting for potential confounders. Compared to participants without depressive symptoms and with a high frequency of participation in social activities, participants with depressive symptoms and a low frequency of participation in social activities were associated with IADL decline (OR 2.45; 95% CI 1.23–4.90). However, we observed no evidence of an interaction effect by employment and participation in social activities.</p></div><div><h3>Conclusions</h3><p>This age-specific cohort study revealed that being employed or participating in social activities may prevent IADL decline among depressed older adults.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100013"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000109/pdfft?md5=b827cbe91fd4aebef854e2d03cfa524a&pid=1-s2.0-S2950307824000109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140014447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.1016/j.aggp.2024.100010
Victoria Pérez , Pablo De Lorena , Carmen Hermosilla-Grijalbo , Esther Domínguez , María Vigueiro-Mallán , Carmen Sarabia-Cobo
Background
The descriptive qualitative study was conducted in three Spanish hospitals during 2023, exploring the experiences of 34 individuals with Mild Cognitive Impairment (MCI) diagnosed during the COVID-19 pandemic.
Objective
To thoroughly investigate the experiences of participants with MCI in the context of the pandemic, identifying challenges, care guidelines, and support, while evaluating the emotional and social impact.
Methods
34 in-depth interviews were conducted, and purposive sampling was used to select participants with MCI. The COREQ recommendations were followed, and ethical approval was obtained.
Results
Five specific themes emerged: (1) Impact of Diagnosis in the Pandemic, (2) Daily Challenges and Pandemic, (3) Care Guidelines and Professional Support, (4) Social and Emotional Support in the Context of the Pandemic, and (5) Fear and Uncertainty. Participants expressed the need for an integrated approach and personalized care.
Conclusions
The results highlight the importance of clear communication and patient-centered care in managing MCI during the pandemic. The implementation of person-centered diagnosis and treatment processes is suggested. The need for future research evaluating effective coping strategies and the influence of fragmented care on disease progression is emphasized.
{"title":"“Exploring the experiences of individuals with mild cognitive impairment during the COVID-19 pandemic: A qualitative study in Spanish hospitals”","authors":"Victoria Pérez , Pablo De Lorena , Carmen Hermosilla-Grijalbo , Esther Domínguez , María Vigueiro-Mallán , Carmen Sarabia-Cobo","doi":"10.1016/j.aggp.2024.100010","DOIUrl":"10.1016/j.aggp.2024.100010","url":null,"abstract":"<div><h3>Background</h3><p>The descriptive qualitative study was conducted in three Spanish hospitals during 2023, exploring the experiences of 34 individuals with Mild Cognitive Impairment (MCI) diagnosed during the COVID-19 pandemic.</p></div><div><h3>Objective</h3><p>To thoroughly investigate the experiences of participants with MCI in the context of the pandemic, identifying challenges, care guidelines, and support, while evaluating the emotional and social impact.</p></div><div><h3>Methods</h3><p>34 in-depth interviews were conducted, and purposive sampling was used to select participants with MCI. The COREQ recommendations were followed, and ethical approval was obtained.</p></div><div><h3>Results</h3><p>Five specific themes emerged: (1) Impact of Diagnosis in the Pandemic, (2) Daily Challenges and Pandemic, (3) Care Guidelines and Professional Support, (4) Social and Emotional Support in the Context of the Pandemic, and (5) Fear and Uncertainty. Participants expressed the need for an integrated approach and personalized care.</p></div><div><h3>Conclusions</h3><p>The results highlight the importance of clear communication and patient-centered care in managing MCI during the pandemic. The implementation of person-centered diagnosis and treatment processes is suggested. The need for future research evaluating effective coping strategies and the influence of fragmented care on disease progression is emphasized.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100010"},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000079/pdfft?md5=3d78f8098ab55114fe0ade8f30f664fd&pid=1-s2.0-S2950307824000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.1016/j.aggp.2024.100011
Justin T Mierzwicki, Joshua Kline, Brooke Schach, Lauren Vandenberg
Purpose/hypothesis
Loneliness and social isolation increase the risk of morbidity, and mortality. Various interventions, with and without use of technology, have improved older adults’ loneliness. The purpose of the study was to compare the impact of telephone versus video communications on perceived loneliness in older adults. It was hypothesized that video communication would result in improved outcomes compared to telephone communication.
Materials/methods
Eighteen hundred flyers were distributed among continuing care communities, meals on wheels, and snowball sampling was encouraged. Sixty-five potential participants responded, 44 were eligible to participate after application of inclusion and exclusion criteria. Participants were assigned into a telephone interaction group (n = 17), a video interaction group (n = 14), or control group (n = 13). Study duration was 8 weeks and consisted of once weekly 45 to 60-minute sessions. Pre-post-intervention outcome measures included UCLA Loneliness Scales (3 and 20-item), and the Social Frailty Scale (SFS). Data analyses were performed with One-Way ANOVA and Tukey's HSD post hoc tests.
Results
One-way ANOVA demonstrated statistically significant differences between groups (p=.003 UCLA 3, p<.001 UCLA 20, p<.001 SFS) with large effect sizes (eta2= 0.251 UCLA3, 0.410 UCLA20, 0.314 SFS). Tukey's HSD demonstrates statistically significant differences between intervention groups and the control group for each dependent variable (p<.011) but identified no significant differences between intervention groups for any dependent variables (p>.283).
Conclusion
Health care professionals can improve loneliness and social isolation through low-tech telephone and video-based communication interventions.
{"title":"Loneliness improved by either telephone or video communications in community-dwelling older adults","authors":"Justin T Mierzwicki, Joshua Kline, Brooke Schach, Lauren Vandenberg","doi":"10.1016/j.aggp.2024.100011","DOIUrl":"10.1016/j.aggp.2024.100011","url":null,"abstract":"<div><h3>Purpose/hypothesis</h3><p>Loneliness and social isolation increase the risk of morbidity, and mortality. Various interventions, with and without use of technology, have improved older adults’ loneliness. The purpose of the study was to compare the impact of telephone versus video communications on perceived loneliness in older adults. It was hypothesized that video communication would result in improved outcomes compared to telephone communication.</p></div><div><h3>Materials/methods</h3><p>Eighteen hundred flyers were distributed among continuing care communities, meals on wheels, and snowball sampling was encouraged. Sixty-five potential participants responded, 44 were eligible to participate after application of inclusion and exclusion criteria. Participants were assigned into a telephone interaction group (<em>n</em> = 17), a video interaction group (<em>n</em> = 14), or control group (<em>n</em> = 13). Study duration was 8 weeks and consisted of once weekly 45 to 60-minute sessions. Pre-post-intervention outcome measures included UCLA Loneliness Scales (3 and 20-item), and the Social Frailty Scale (SFS). Data analyses were performed with One-Way ANOVA and Tukey's HSD post hoc tests.</p></div><div><h3>Results</h3><p>One-way ANOVA demonstrated statistically significant differences between groups (<em>p</em>=.003 UCLA 3, <em>p</em><.001 UCLA 20, <em>p</em><.001 SFS) with large effect sizes (eta<sup>2</sup>= 0.251 UCLA3, 0.410 UCLA20, 0.314 SFS). Tukey's HSD demonstrates statistically significant differences between intervention groups and the control group for each dependent variable (<em>p</em><.011) but identified no significant differences between intervention groups for any dependent variables (<em>p</em>>.283).</p></div><div><h3>Conclusion</h3><p>Health care professionals can improve loneliness and social isolation through low-tech telephone and video-based communication interventions.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100011"},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000080/pdfft?md5=c39ab3956438fb2b4747271fe49abef5&pid=1-s2.0-S2950307824000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09DOI: 10.1016/j.aggp.2024.100009
Kasumi Ikuta , Sakiko Fukui
Aim
To our knowledge, no studies have examined the risk of mortality in nursing homes using the routinely collected electronic care record information. We aimed to assess the risk of mortality using food intake data documented in electronic care records from Japanese nursing homes.
Methods
This academic–industry collaborative research included 814 older adults from five nursing homes in Japan. The study period was from January 1, 2016 to June 23, 2020. We used the rate of food intake data recorded by care workers in the electronic care records of the residents. We defined decreased food intake as the percentage decrease between admission and 90 days after admission into the nursing home, with cutoffs of 10%, 20%, and 30%.
Results
The number of older adults whose food intake decreased between admission and 90 days after admission was 114 (14.0%) at a 10% rate, 58 (7.1%) at a 20% rate, and 35 (4.3%) at a 30% rate. All three rates were significantly associated with mortality (10%: hazard ratio [HR] 2.02, 95% confidence interval [CI] 1.30–3.15; 20%: HR 3.03, 95% CI 1.68–5.47; and 30%: HR 4.50, 95% CI 2.15–9.44).
Conclusions
We found that the risk of mortality could conveniently be assessed from the food intake data collected routinely and comprehensively and documented in electronic care records in nursing homes. Our findings can be utilized in nursing homes, where medical staff are limited, to assess high-risk residents and to encourage a discussion regarding the management of end-of-life care.
{"title":"Mortality from decreased food intake in older adults in nursing homes: A retrospective cohort study using electronic care record data","authors":"Kasumi Ikuta , Sakiko Fukui","doi":"10.1016/j.aggp.2024.100009","DOIUrl":"10.1016/j.aggp.2024.100009","url":null,"abstract":"<div><h3>Aim</h3><p>To our knowledge, no studies have examined the risk of mortality in nursing homes using the routinely collected electronic care record information. We aimed to assess the risk of mortality using food intake data documented in electronic care records from Japanese nursing homes.</p></div><div><h3>Methods</h3><p>This academic–industry collaborative research included 814 older adults from five nursing homes in Japan. The study period was from January 1, 2016 to June 23, 2020. We used the rate of food intake data recorded by care workers in the electronic care records of the residents. We defined decreased food intake as the percentage decrease between admission and 90 days after admission into the nursing home, with cutoffs of 10%, 20%, and 30%.</p></div><div><h3>Results</h3><p>The number of older adults whose food intake decreased between admission and 90 days after admission was 114 (14.0%) at a 10% rate, 58 (7.1%) at a 20% rate, and 35 (4.3%) at a 30% rate. All three rates were significantly associated with mortality (10%: hazard ratio [HR] 2.02, 95% confidence interval [CI] 1.30–3.15; 20%: HR 3.03, 95% CI 1.68–5.47; and 30%: HR 4.50, 95% CI 2.15–9.44).</p></div><div><h3>Conclusions</h3><p>We found that the risk of mortality could conveniently be assessed from the food intake data collected routinely and comprehensively and documented in electronic care records in nursing homes. Our findings can be utilized in nursing homes, where medical staff are limited, to assess high-risk residents and to encourage a discussion regarding the management of end-of-life care.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 2","pages":"Article 100009"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000067/pdfft?md5=e331f47be51d711445712db23c348b3d&pid=1-s2.0-S2950307824000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.1016/j.aggp.2024.100008
R.C. Ambagtsheer , K. Borg , L Townsin , M.A. Pinero de Plaza , L.M. O'Brien , R. Kunwar , M.T. Lawless
Objectives
This study reviewed technology-based interventions targeting social isolation and loneliness in community-dwelling older adults. Specific aims were to identify theoretical perspectives, assess intervention effectiveness, and identify barriers and enablers of these interventions.
Methods
A mixed methods systematic review of intervention studies was conducted, searching six databases (PubMed, PsychINFO, Cochrane Library, CINAHL, ACM and Embase). Peer-reviewed articles describing communicative technology-based intervention studies with qualitative, quantitative, mixed-method, or observational designs, conducted in community settings with older adults (aged ≥65 years), where social isolation and/or loneliness were key outcome measures, were included. The quality of the studies was assessed using the Mixed Methods Appraisal Tool (MMAT).
Results
Nineteen studies were included in the review. Theory integration was rare in these studies’ research designs. Most were small-scale pilot or feasibility studies, displaying diverse designs, small sample sizes, and variable MMAT-assessed quality. The studies highlighted significant barriers such as resource demands, participant health, literacy, and technical challenges.
Conclusion
Significant resource demands continue to impede technology-based interventions addressing social isolation and loneliness in older populations. Future study designs must adapt to overcome these challenges, tailoring approaches to marginalised and often frail communities these interventions aim to support.
{"title":"The effectiveness of technology interventions in reducing social isolation and loneliness among community-dwelling older people: A mixed methods systematic review","authors":"R.C. Ambagtsheer , K. Borg , L Townsin , M.A. Pinero de Plaza , L.M. O'Brien , R. Kunwar , M.T. Lawless","doi":"10.1016/j.aggp.2024.100008","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100008","url":null,"abstract":"<div><h3>Objectives</h3><p>This study reviewed technology-based interventions targeting social isolation and loneliness in community-dwelling older adults. Specific aims were to identify theoretical perspectives, assess intervention effectiveness, and identify barriers and enablers of these interventions.</p></div><div><h3>Methods</h3><p>A mixed methods systematic review of intervention studies was conducted, searching six databases (PubMed, PsychINFO, Cochrane Library, CINAHL, ACM and Embase). Peer-reviewed articles describing communicative technology-based intervention studies with qualitative, quantitative, mixed-method, or observational designs, conducted in community settings with older adults (aged ≥65 years), where social isolation and/or loneliness were key outcome measures, were included. The quality of the studies was assessed using the Mixed Methods Appraisal Tool (MMAT).</p></div><div><h3>Results</h3><p>Nineteen studies were included in the review. Theory integration was rare in these studies’ research designs. Most were small-scale pilot or feasibility studies, displaying diverse designs, small sample sizes, and variable MMAT-assessed quality. The studies highlighted significant barriers such as resource demands, participant health, literacy, and technical challenges.</p></div><div><h3>Conclusion</h3><p>Significant resource demands continue to impede technology-based interventions addressing social isolation and loneliness in older populations. Future study designs must adapt to overcome these challenges, tailoring approaches to marginalised and often frail communities these interventions aim to support.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 1","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000055/pdfft?md5=a10c74659d835197f6528823269a6976&pid=1-s2.0-S2950307824000055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139715024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.aggp.2024.100011
Justin T. Mierzwicki, Joshua Kline, Brooke Schach, Lauren Vandenberg
{"title":"LONELINESS IMPROVED BY EITHER TELEPHONE OR VIDEO COMMUNICATIONS IN COMMUNITY-DWELLING OLDER ADULTS","authors":"Justin T. Mierzwicki, Joshua Kline, Brooke Schach, Lauren Vandenberg","doi":"10.1016/j.aggp.2024.100011","DOIUrl":"https://doi.org/10.1016/j.aggp.2024.100011","url":null,"abstract":"","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"85 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}