Gait in older adults frequently entails augmented forward trunk tilt (FTT) and diminished hip extension, resulting in diminished stride length. However, the relationship between these factors remains unclear. The objective of this study was to verify the hypothesis that an augmented FTT angle impedes hip extension angles during gait, consequently diminishing stride length and walking speed.
Methods
A secondary analysis was conducted using data from previous studies. The Microsoft Kinect V2 sensor was utilized to track the coordinates of the lower extremities and trunk during gait. Spatiotemporal variables, including walking speed and stride length, were calculated alongside peak FTT and hip extension angles.
Results
The optimal model, as indicated by the highest values for goodness-of-fit indices (goodness-of-fit index = 0.98, adjusted goodness-of-fit index = 0.91, comparative fit index = 0.98, root mean square error of approximation = 0.11), demonstrated that an augmented peak FTT angle results in a diminished peak hip extension angle during gait, consequently leading to a reduction in stride length and walking speed.
Conclusion
In older adults, reduced walking speed is associated with shorter stride length, primarily due to decreased hip extension angle. The increased peak FTT angle contributes to this reduction in hip extension. To prevent decreases in walking speed, it is recommended that older adults engage in exercises that focus on trunk stabilization and hip extension.
{"title":"Influence of increased forward trunk tilt angle on stride length shortening during gait in older adults: Secondary analysis","authors":"Ryo Tanaka , Hungu Jung , Shunsuke Yamashina , Yu Inoue , Haruki Toda , Takeshi Imura , Hiroyuki Tamura","doi":"10.1016/j.aggp.2025.100174","DOIUrl":"10.1016/j.aggp.2025.100174","url":null,"abstract":"<div><h3>Background</h3><div>Gait in older adults frequently entails augmented forward trunk tilt (FTT) and diminished hip extension, resulting in diminished stride length. However, the relationship between these factors remains unclear. The objective of this study was to verify the hypothesis that an augmented FTT angle impedes hip extension angles during gait, consequently diminishing stride length and walking speed.</div></div><div><h3>Methods</h3><div>A secondary analysis was conducted using data from previous studies. The Microsoft Kinect V2 sensor was utilized to track the coordinates of the lower extremities and trunk during gait. Spatiotemporal variables, including walking speed and stride length, were calculated alongside peak FTT and hip extension angles.</div></div><div><h3>Results</h3><div>The optimal model, as indicated by the highest values for goodness-of-fit indices (goodness-of-fit index = 0.98, adjusted goodness-of-fit index = 0.91, comparative fit index = 0.98, root mean square error of approximation = 0.11), demonstrated that an augmented peak FTT angle results in a diminished peak hip extension angle during gait, consequently leading to a reduction in stride length and walking speed.</div></div><div><h3>Conclusion</h3><div>In older adults, reduced walking speed is associated with shorter stride length, primarily due to decreased hip extension angle. The increased peak FTT angle contributes to this reduction in hip extension. To prevent decreases in walking speed, it is recommended that older adults engage in exercises that focus on trunk stabilization and hip extension.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poor health significantly impacts productive years of life. This study examines hypertension onset and survival probabilities for hypertension among adults aged 60 years and above, focusing on variations by working status and occupational profile.
Data and methods
The study utilized data from the first wave of the Longitudinal Ageing Study in India (2017–2018), comprising a sample of 31,782 individuals aged 60 years and above (15,293 males and 16,489 females). The primary outcome variable was the onset of hypertension, which was self-reported but confirmed by a health professional. The year of diagnosis was recorded as the onset year of hypertension. To achieve the study objectives, descriptive statistical analyses and Cox proportional hazards models were applied.
Results
The study revealed that approximately 41.01% of males and 33.62% of females were expected to remain free from hypertension beyond the age of 80. The onset of hypertension showed a marked acceleration after the age of 40, with an inverse relationship between increasing age and hypertension-free survival. Additionally, working older adults were found to have a 21% lower likelihood of developing hypertension compared to those who had previously worked but were currently not working.
Conclusion
The findings indicate that continued economic activity in later life is associated with improved survival rates and a delayed onset of hypertension among older adults. These results underscore the importance of promoting active and healthy aging through policies.
{"title":"Unravelling the occupational factor and hypertension puzzle among Indian older adults","authors":"Priya Maurya , Aparajita Chattopadhyay , Palak Sharma","doi":"10.1016/j.aggp.2025.100172","DOIUrl":"10.1016/j.aggp.2025.100172","url":null,"abstract":"<div><h3>Background</h3><div>Poor health significantly impacts productive years of life. This study examines hypertension onset and survival probabilities for hypertension among adults aged 60 years and above, focusing on variations by working status and occupational profile.</div></div><div><h3>Data and methods</h3><div>The study utilized data from the first wave of the Longitudinal Ageing Study in India (2017–2018), comprising a sample of 31,782 individuals aged 60 years and above (15,293 males and 16,489 females). The primary outcome variable was the onset of hypertension, which was self-reported but confirmed by a health professional. The year of diagnosis was recorded as the onset year of hypertension. To achieve the study objectives, descriptive statistical analyses and Cox proportional hazards models were applied.</div></div><div><h3>Results</h3><div>The study revealed that approximately 41.01% of males and 33.62% of females were expected to remain free from hypertension beyond the age of 80. The onset of hypertension showed a marked acceleration after the age of 40, with an inverse relationship between increasing age and hypertension-free survival. Additionally, working older adults were found to have a 21% lower likelihood of developing hypertension compared to those who had previously worked but were currently not working.</div></div><div><h3>Conclusion</h3><div>The findings indicate that continued economic activity in later life is associated with improved survival rates and a delayed onset of hypertension among older adults. These results underscore the importance of promoting active and healthy aging through policies.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-17DOI: 10.1016/j.aggp.2025.100168
Sulaiman Alshakhs M.D., Sara Mohamed, Ibtihal Kamal, Sa'ad Laws, Mai A. Mahmoud MBBS, MEHP
Background
Frailty is a multidimensional syndrome associated with increased risk of adverse health outcomes in older adults. As Middle Eastern populations age, validated frailty assessment tools (FATs) are essential to inform care planning. However, regional uptake and validation remain unclear.
Objective
This scoping review aimed to map the use and validation of FATs among adults aged 55 and above in the Middle East, identify research gaps, and explore cross-country trends.
Methods
Following PRISMA-ScR guidelines, a comprehensive literature search was conducted in May 2022 and updated in December 2024 across PubMed, Embase, Web of Science, and Scopus. Search terms targeted “frailty,” “geriatric,” and 17 Middle Eastern countries. Inclusion criteria comprised primary studies using or discussing FATs among adults aged 55+, conducted in or including a Middle Eastern country. Non-English/Arabic texts, non-primary literature, and studies lacking frailty definitions or tools were excluded. In total, 103 studies were included.
Results
The Clinical Frailty Scale (CFS) and Fried Frailty Phenotype (FFP) were the most commonly used tools, appearing in 36 and 32 studies respectively. However, only 12 studies reported tool validation, and just 7 conducted cultural adaptation. Research output was highest in Turkey (28 studies), Iran (17), and Saudi Arabia (14), while 6 countries had no studies. Most studies used FATs in hospital settings.
Conclusion
Frailty research is growing in the Middle East but remains fragmented and under-validated. Standardized tools adapted to local contexts are urgently needed. Strengthening clinical care and policy will require greater regional collaboration and investment in culturally relevant research
背景：虚弱是一种多维综合征，与老年人不良健康结局风险增加相关。随着中东人口的老龄化，经过验证的衰弱评估工具（fat）对于为护理规划提供信息至关重要。然而，区域吸收和验证仍不清楚。目的：本综述旨在绘制中东地区55岁及以上成年人中脂肪的使用和验证图，确定研究空白，并探索跨国趋势。方法遵循PRISMA-ScR指南，于2022年5月对PubMed、Embase、Web of Science和Scopus进行了全面的文献检索，并于2024年12月进行了更新。搜索词的目标是“虚弱”、“老年”和17个中东国家。纳入标准包括在中东国家或包括中东国家进行的55岁以上成年人中使用或讨论脂肪的初步研究。非英语/阿拉伯语文本、非主要文献和缺乏脆弱性定义或工具的研究被排除在外。总共纳入103项研究。结果临床虚弱量表（CFS）和油炸虚弱表型（FFP）是最常用的评估工具，分别出现在36项和32项研究中。然而，只有12项研究报告了工具验证，只有7项研究进行了文化适应。研究产出最高的是土耳其（28篇）、伊朗（17篇）和沙特阿拉伯（14篇），6个国家没有研究。大多数研究在医院环境中使用脂肪。结论衰弱研究在中东地区正在增长，但仍然是碎片化和缺乏验证的。迫切需要适应当地情况的标准化工具。加强临床护理和政策将需要在文化相关研究方面加强区域合作和投资
{"title":"The scope of frailty assessment tools in the middle east: unraveling gaps and trends","authors":"Sulaiman Alshakhs M.D., Sara Mohamed, Ibtihal Kamal, Sa'ad Laws, Mai A. Mahmoud MBBS, MEHP","doi":"10.1016/j.aggp.2025.100168","DOIUrl":"10.1016/j.aggp.2025.100168","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a multidimensional syndrome associated with increased risk of adverse health outcomes in older adults. As Middle Eastern populations age, validated frailty assessment tools (FATs) are essential to inform care planning. However, regional uptake and validation remain unclear.</div></div><div><h3>Objective</h3><div>This scoping review aimed to map the use and validation of FATs among adults aged 55 and above in the Middle East, identify research gaps, and explore cross-country trends.</div></div><div><h3>Methods</h3><div>Following PRISMA-ScR guidelines, a comprehensive literature search was conducted in May 2022 and updated in December 2024 across PubMed, Embase, Web of Science, and Scopus. Search terms targeted “frailty,” “geriatric,” and 17 Middle Eastern countries. Inclusion criteria comprised primary studies using or discussing FATs among adults aged 55+, conducted in or including a Middle Eastern country. Non-English/Arabic texts, non-primary literature, and studies lacking frailty definitions or tools were excluded. In total, 103 studies were included.</div></div><div><h3>Results</h3><div>The Clinical Frailty Scale (CFS) and Fried Frailty Phenotype (FFP) were the most commonly used tools, appearing in 36 and 32 studies respectively. However, only 12 studies reported tool validation, and just 7 conducted cultural adaptation. Research output was highest in Turkey (28 studies), Iran (17), and Saudi Arabia (14), while 6 countries had no studies. Most studies used FATs in hospital settings.</div></div><div><h3>Conclusion</h3><div>Frailty research is growing in the Middle East but remains fragmented and under-validated. Standardized tools adapted to local contexts are urgently needed. Strengthening clinical care and policy will require greater regional collaboration and investment in culturally relevant research</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This cross-sectional study aimed to investigate whether the ability to maintain one-leg standing test for varying durations (10, 30, or 60 s) is associated with physical function and fall history.
Methods
158 community-dwelling older adults participated. They performed the one-leg standing test for a maximum of 60 s and were categorized into those who could or could not maintain the position at each time point. Physical function was assessed through mobility (gait speed and five times sit-to-stand test), balance (Timed Up and Go (TUG) test and two-step test), and knee extension strength. Fall history was self-reported.
Results
The proportions unable to maintain standing increased with test durations: 14.6 % for 10 s, 26.6 % for 30 s, and 41.1 % for 60 s. Independent t-tests showed that the maintained groups demonstrated significantly better mobility and balance performance than the non-maintained groups at each duration (all p < 0.01), and that the maintained groups at 10 s and 30 s exhibited significantly greater knee extension strength (p < 0.01). Multiple regression analyses confirmed that the one-leg standing was independently associated with physical function outcomes. Chi-square tests revealed no significant association between standing duration and fall history.
Conclusions
The one-leg standing test was consistently associated with physical function but showed limited ability to predict fall history. A shorter duration (10 s) effectively detected severe impairments, whereas a longer duration (60 s) was more sensitive for identifying early declines. The choice of test duration should be guided by the specific functional deficits being assessed.
目的：本横断面研究旨在调查维持不同时间（10、30或60秒）单腿站立测试的能力是否与身体功能和跌倒史有关。方法158名社区老年人参与调查。他们进行了最长60秒的单腿站立测试，并在每个时间点被分为能够和不能保持站立姿势的两组。通过活动能力（步态速度和五次坐立测试）、平衡能力（定时起身（TUG）测试和两步测试）和膝关节伸展强度来评估身体功能。秋天的历史是自我报告的。结果不能站立的比例随试验时间的延长而增加：10 s 14.6%, 30 s 26.6%, 60 s 41.1%。独立t检验显示，维持组在每个持续时间内的活动能力和平衡能力明显优于非维持组(p <；0.01)，维持10 s和30 s组的膝关节伸展强度显著高于对照组(p <；0.01)。多元回归分析证实单腿站立与身体功能结果独立相关。卡方检验显示站立时间与跌倒史之间无显著关联。结论单腿站立试验与身体功能一致，但预测跌倒史的能力有限。较短的持续时间（10秒）可以有效地检测到严重的损伤，而较长的持续时间（60秒）对于识别早期衰退更敏感。测试持续时间的选择应以评估的具体功能缺陷为指导。
{"title":"Optimizing one-leg standing test duration for screening functional decline in community-dwelling older adults","authors":"Akira Iwata , Izumi Arihara , Keita Sasada , Atsuki Kanayama , Kenichiro Tsubokura , Gaito Kitada , Ryoga Ueba , Shuji Okuno , Toshimitsu Ohmine , Saki Yamamoto","doi":"10.1016/j.aggp.2025.100169","DOIUrl":"10.1016/j.aggp.2025.100169","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study aimed to investigate whether the ability to maintain one-leg standing test for varying durations (10, 30, or 60 s) is associated with physical function and fall history.</div></div><div><h3>Methods</h3><div>158 community-dwelling older adults participated. They performed the one-leg standing test for a maximum of 60 s and were categorized into those who could or could not maintain the position at each time point. Physical function was assessed through mobility (gait speed and five times sit-to-stand test), balance (Timed Up and Go (TUG) test and two-step test), and knee extension strength. Fall history was self-reported.</div></div><div><h3>Results</h3><div>The proportions unable to maintain standing increased with test durations: 14.6 % for 10 s, 26.6 % for 30 s, and 41.1 % for 60 s. Independent <em>t</em>-tests showed that the maintained groups demonstrated significantly better mobility and balance performance than the non-maintained groups at each duration (all <em>p</em> < 0.01), and that the maintained groups at 10 s and 30 s exhibited significantly greater knee extension strength (<em>p</em> < 0.01). Multiple regression analyses confirmed that the one-leg standing was independently associated with physical function outcomes. Chi-square tests revealed no significant association between standing duration and fall history.</div></div><div><h3>Conclusions</h3><div>The one-leg standing test was consistently associated with physical function but showed limited ability to predict fall history. A shorter duration (10 s) effectively detected severe impairments, whereas a longer duration (60 s) was more sensitive for identifying early declines. The choice of test duration should be guided by the specific functional deficits being assessed.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-08DOI: 10.1016/j.aggp.2025.100161
Hamza Ehtesham , Ahmed Kamal Siddiqi , Marium Omair Mirza , Mushtaq Ahmad , Rija Shakil
Background
With increasing age in the United States, the disease burden of chronic kidney disease (CKD) has increased. The CKD-related mortality trends have not been explored for individuals aged ≥ 65 years. The aim of the study was to identify and evaluate the trends in sex, race, and region among CKD-related mortality in older adults.
Methods
Death records sourced from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database were used to analyze mortality trends of CKD in individuals aged ≥65 years from 1999 to 2020. We computed age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent changes (APC) using Joinpoint software. The analysis was structured according to year, sex, race/ethnicity, and geographical regions.
Results
From 1999 to 2020, there were 1,572,057 CKD-related deaths. The age-adjusted mortality rate (AAMR) rose from 1999 to 2005, declined until 2009, surged from 2009 to 2012, fell in 2015, and increased again in 2020. Men had a higher AAMR (225) than women (136.3). Non-Hispanic Black or African Americans experienced the highest AAMR (319.2), followed by NH American Indian or Alaska Native (229.5), Hispanic (178.5), NH white (154.5), and NH Asian or Pacific Islander (144.1). Regionally, AAMR was highest in the Midwest (184.6) and lower in non-metropolitan areas (133.3) compared to metropolitan areas (126.3).
Conclusion
CKD-related mortality is rising among U.S. adults ≥ 65, especially in non-Hispanic African American males in the Midwest and rural areas. Screening high-risk individuals can enable early detection and lower mortality rates.
{"title":"Trends in chronic kidney disease-related mortality among older adults in the United States from 1999-2020","authors":"Hamza Ehtesham , Ahmed Kamal Siddiqi , Marium Omair Mirza , Mushtaq Ahmad , Rija Shakil","doi":"10.1016/j.aggp.2025.100161","DOIUrl":"10.1016/j.aggp.2025.100161","url":null,"abstract":"<div><h3>Background</h3><div>With increasing age in the United States, the disease burden of chronic kidney disease (CKD) has increased. The CKD-related mortality trends have not been explored for individuals aged ≥ 65 years. The aim of the study was to identify and evaluate the trends in sex, race, and region among CKD-related mortality in older adults.</div></div><div><h3>Methods</h3><div>Death records sourced from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database were used to analyze mortality trends of CKD in individuals aged ≥65 years from 1999 to 2020. We computed age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent changes (APC) using Joinpoint software. The analysis was structured according to year, sex, race/ethnicity, and geographical regions.</div></div><div><h3>Results</h3><div>From 1999 to 2020, there were 1,572,057 CKD-related deaths. The age-adjusted mortality rate (AAMR) rose from 1999 to 2005, declined until 2009, surged from 2009 to 2012, fell in 2015, and increased again in 2020. Men had a higher AAMR (225) than women (136.3). Non-Hispanic Black or African Americans experienced the highest AAMR (319.2), followed by NH American Indian or Alaska Native (229.5), Hispanic (178.5), NH white (154.5), and NH Asian or Pacific Islander (144.1). Regionally, AAMR was highest in the Midwest (184.6) and lower in non-metropolitan areas (133.3) compared to metropolitan areas (126.3).</div></div><div><h3>Conclusion</h3><div>CKD-related mortality is rising among U.S. adults ≥ 65, especially in non-Hispanic African American males in the Midwest and rural areas. Screening high-risk individuals can enable early detection and lower mortality rates.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-07DOI: 10.1016/j.aggp.2025.100167
Liang-Kung Chen MD, PhD
{"title":"Social factors and nutritional health in aging","authors":"Liang-Kung Chen MD, PhD","doi":"10.1016/j.aggp.2025.100167","DOIUrl":"10.1016/j.aggp.2025.100167","url":null,"abstract":"","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-07DOI: 10.1016/j.aggp.2025.100166
Yan Su , Sheng Cai , Yang Xu , Xianwen Chen
Object
Parkinson's disease (PD) is a neurodegenerative disease with different subtypes. More accurate subtype classification is significant for understanding the pathogenesis of PD, predicting disease progression, and selecting effective treatment methods. A bibliometric analysis of relevant research on PD subtypes is presented in this study.
Methods
Original research and review articles related to PD subtypes from January 1, 2015 to December 31, 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. After screening, 2213 articles were obtained. Statistical analysis and visualization of country, institution, author, journal, and keyword information contained in the studies were performed using CiteSpace (v6.2. R4) and VOSviewer (v1.6.20.0) software to identify research hotspots and trends in the field.
Result
The 2213 articles used in this study were from 11740 authors from 3117 institutions in 93 countries and published in 481 journals. From the analysis, it was found that the number of annual publications in this field has been increasing year by year in the past 10 years. The United States contributed the most to this research direction, with the largest number of publications (604) and citations (31, 284), and the strongest connection with other countries. 'Motor disorder ' is the most frequently cited journal, and ' Parkinson 's disease-related disorder ' is the most frequently published journal. "Parkinson's Disease", "Dementia", "Subtypes", and "Progress" are frequently used keywords, while "Rem sleep", "networs", and "machine learning" are the focus of research in recent years.
Conclusion
The bibliometric analysis offers a comprehensive insight into present research focal points and evolving patterns associated with PD subtypes. High-frequency keywords pinpointed underscore dynamic research fields encompassing methodologies, mechanisms, and engaged populations. These findings can provide guidance for future research on PD subtypes.
目的帕金森病（PD）是一种具有不同亚型的神经退行性疾病。更准确的亚型分类对于了解PD的发病机制，预测疾病进展，选择有效的治疗方法具有重要意义。本文对PD亚型的相关研究进行文献计量学分析。方法从Web of Science Core Collection （WOSCC）数据库中检索2015年1月1日至2024年12月31日与PD亚型相关的原始研究和综述文章。经筛选，得到2213篇。使用CiteSpace （v6.2）对研究中包含的国家、机构、作者、期刊和关键字信息进行统计分析和可视化。R4)和VOSviewer （v1.6.20.0）软件，识别该领域的研究热点和趋势。结果本研究共纳入来自93个国家3117个机构的11740位作者的2213篇文献，发表于481种期刊。通过分析发现，近10年来，该领域的年度出版物数量逐年增加。美国对这一研究方向的贡献最大，发表论文604篇，被引用次数31,284次，与其他国家联系最紧密。“运动障碍”是最常被引用的期刊，“帕金森病相关障碍”是最常发表的期刊。“帕金森病”、“痴呆”、“亚型”、“进展”是频繁使用的关键词，而“Rem睡眠”、“网络”、“机器学习”是近年来的研究热点。结论文献计量学分析提供了对当前研究重点和PD亚型相关演变模式的全面洞察。精确的高频关键词强调了包括方法、机制和参与人群在内的动态研究领域。这些发现可以为今后PD亚型的研究提供指导。
{"title":"Global research trends on subtypes of Parkinson's disease: A visual bibliometric analysis","authors":"Yan Su , Sheng Cai , Yang Xu , Xianwen Chen","doi":"10.1016/j.aggp.2025.100166","DOIUrl":"10.1016/j.aggp.2025.100166","url":null,"abstract":"<div><h3>Object</h3><div>Parkinson's disease (PD) is a neurodegenerative disease with different subtypes. More accurate subtype classification is significant for understanding the pathogenesis of PD, predicting disease progression, and selecting effective treatment methods. A bibliometric analysis of relevant research on PD subtypes is presented in this study.</div></div><div><h3>Methods</h3><div>Original research and review articles related to PD subtypes from January 1, 2015 to December 31, 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. After screening, 2213 articles were obtained. Statistical analysis and visualization of country, institution, author, journal, and keyword information contained in the studies were performed using CiteSpace (v6.2. R4) and VOSviewer (v1.6.20.0) software to identify research hotspots and trends in the field.</div></div><div><h3>Result</h3><div>The 2213 articles used in this study were from 11740 authors from 3117 institutions in 93 countries and published in 481 journals. From the analysis, it was found that the number of annual publications in this field has been increasing year by year in the past 10 years. The United States contributed the most to this research direction, with the largest number of publications (604) and citations (31, 284), and the strongest connection with other countries. 'Motor disorder ' is the most frequently cited journal, and ' Parkinson 's disease-related disorder ' is the most frequently published journal. \"Parkinson's Disease\", \"Dementia\", \"Subtypes\", and \"Progress\" are frequently used keywords, while \"Rem sleep\", \"networs\", and \"machine learning\" are the focus of research in recent years.</div></div><div><h3>Conclusion</h3><div>The bibliometric analysis offers a comprehensive insight into present research focal points and evolving patterns associated with PD subtypes. High-frequency keywords pinpointed underscore dynamic research fields encompassing methodologies, mechanisms, and engaged populations. These findings can provide guidance for future research on PD subtypes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-26DOI: 10.1016/j.aggp.2025.100165
Thomas Fraccalini , Andrea Trogolo , Monica Traversa , Beatrice Tarozzo , Luciano Cardinale , Giuseppe Maina , Salvatore Di Gioia , Davide Minniti , Ivana Finiguerra , Roberta Vacchelli , Martina Battaglia , Angelica Ruggeri , Valerio Ricci , Alessandro Maraschi , Thomas Roberts , Giovanni Volpicelli , Luca Tagliafico
Background
Delirium, a severe neuropsychiatric syndrome characterised by acute deficits in attention and self-awareness, is common among elderly inpatients, with incidence increasing with age and prolonged hospitalisation. This study examines the characteristics of geriatric patients developing delirium in the Emergency Medicine Department, focusing on the relationship between frailty at admission and delirium onset, and how these factors influence hospitalisation decisions and prognosis.
Methods
A prospective, observational study was conducted on patients aged 65+ admitted to the Emergency Department for over 24 hours. Comorbidities (e.g., dementia, cardiovascular diseases, diabetes, COPD, depression, Parkinson’s) and pharmacological therapies (e.g., antipsychotics, antidepressants) were recorded. Frailty was assessed using the Clinical Frailty Scale (CFS).
Results
Among 89 patients (mean age 83.94; 48 women, 41 men), 66.29 % developed delirium, 76.40 % required hospitalisation, and 31.46 % died during their stay. Significant associations were found between delirium and age (p = 0.0025), antipsychotic use (p < 0.0001), CFS score (p = 0.014), and number of medications at admission (p = 0.009). Delirium was also significantly linked to Alzheimer’s disease (p = 0.0033), other dementias (p = 0.0021), anxiety-depressive disorders (p = 0.004), behavioural and psychological symptoms of dementia (BPSD) (p < 0.0001), and mortality (p < 0.0001).
Conclusion
Frailty and delirium are critical factors influencing hospitalisation and prognosis in elderly patients. The study highlights the importance of early frailty assessment and medication review in the Emergency Department to mitigate delirium risk and improve outcomes.
{"title":"Delirium in the emergency department: Incidence and risk factors in a Ligurian hospital","authors":"Thomas Fraccalini , Andrea Trogolo , Monica Traversa , Beatrice Tarozzo , Luciano Cardinale , Giuseppe Maina , Salvatore Di Gioia , Davide Minniti , Ivana Finiguerra , Roberta Vacchelli , Martina Battaglia , Angelica Ruggeri , Valerio Ricci , Alessandro Maraschi , Thomas Roberts , Giovanni Volpicelli , Luca Tagliafico","doi":"10.1016/j.aggp.2025.100165","DOIUrl":"10.1016/j.aggp.2025.100165","url":null,"abstract":"<div><h3>Background</h3><div>Delirium, a severe neuropsychiatric syndrome characterised by acute deficits in attention and self-awareness, is common among elderly inpatients, with incidence increasing with age and prolonged hospitalisation. This study examines the characteristics of geriatric patients developing delirium in the Emergency Medicine Department, focusing on the relationship between frailty at admission and delirium onset, and how these factors influence hospitalisation decisions and prognosis.</div></div><div><h3>Methods</h3><div>A prospective, observational study was conducted on patients aged 65+ admitted to the Emergency Department for over 24 hours. Comorbidities (e.g., dementia, cardiovascular diseases, diabetes, COPD, depression, Parkinson’s) and pharmacological therapies (e.g., antipsychotics, antidepressants) were recorded. Frailty was assessed using the Clinical Frailty Scale (CFS).</div></div><div><h3>Results</h3><div>Among 89 patients (mean age 83.94; 48 women, 41 men), 66.29 % developed delirium, 76.40 % required hospitalisation, and 31.46 % died during their stay. Significant associations were found between delirium and age (<em>p</em> = 0.0025), antipsychotic use (<em>p</em> < 0.0001), CFS score (<em>p</em> = 0.014), and number of medications at admission (<em>p</em> = 0.009). Delirium was also significantly linked to Alzheimer’s disease (<em>p</em> = 0.0033), other dementias (<em>p</em> = 0.0021), anxiety-depressive disorders (<em>p</em> = 0.004), behavioural and psychological symptoms of dementia (BPSD) (<em>p</em> < 0.0001), and mortality (<em>p</em> < 0.0001).</div></div><div><h3>Conclusion</h3><div>Frailty and delirium are critical factors influencing hospitalisation and prognosis in elderly patients. The study highlights the importance of early frailty assessment and medication review in the Emergency Department to mitigate delirium risk and improve outcomes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-17DOI: 10.1016/j.aggp.2025.100163
Hala Alosaimi , Haitham Alnouri , Ibrahim Alasiri , Saad Almushawah , Mansour Mohammed , Ameera Abdulrahman , Rana A. Alotaibi , Rasha Alfawaz , Abdulaziz Abdulbaqi , Weam Banjar , Tareef Alaama , Mariam M. AlEissa
Background
Life expectancy is an important indicator of societal health and development. Social and economic determinants of health, political stability, and public policies frequently influence outcomes. Saudi Arabia has made significant strides in improving its population's life expectancy, and the overall trajectory is upwards and positive. Nevertheless, Saudi Arabia continues to face challenges related to controlling noncommunicable diseases. (NCDs), health disparities, and behavioral factors. This study aims to explore global best practices for improving life expectancy and establish recommendations for Saudi policy makers in the health industry and related stakeholders.
Methodology
A robust comparative analysis was used to evaluate the impact of global best practices with respect to the accessibility, efficiency and affordability of different national healthcare systems. It also addresses social determinants of health. Moreover, it looks at national health policies and preventative measures. The primary data sources used include peer-reviewed literature databases such as PubMed, the Lancet and Springer. The data were also derived from reports of global health organizations, such as the WHO, World Bank and OECD publications. The key indicators analysed included healthcare access, cultural/social awareness, education, nutrition, lifestyle, and socioeconomic factors. An online comprehensive questionnaire was sent to analyse data collected from people currently living in the Kingdom of Saudi Arabia.
Results
We introduce several recommendations after looking into countries with high longevity rates. We highlight the need to adopt evidence-based practices to increase life expectancy in Saudi Arabia. New strategies promoting healthy lifestyles through education, regulating unhealthy products, promoting regular physical activity, integrating mental health into primary health, encouraging plant-based diets and improving preventive healthcare are needed. To achieve a healthier and longer-living population aligning with the Kingdom's vision, cultural and socioeconomic barriers should be further addressed by incorporating stress management practices.
{"title":"Advancing life expectancy in Saudi Arabia: insights from global best practices","authors":"Hala Alosaimi , Haitham Alnouri , Ibrahim Alasiri , Saad Almushawah , Mansour Mohammed , Ameera Abdulrahman , Rana A. Alotaibi , Rasha Alfawaz , Abdulaziz Abdulbaqi , Weam Banjar , Tareef Alaama , Mariam M. AlEissa","doi":"10.1016/j.aggp.2025.100163","DOIUrl":"10.1016/j.aggp.2025.100163","url":null,"abstract":"<div><h3>Background</h3><div>Life expectancy is an important indicator of societal health and development. Social and economic determinants of health, political stability, and public policies frequently influence outcomes. Saudi Arabia has made significant strides in improving its population's life expectancy, and the overall trajectory is upwards and positive. Nevertheless, Saudi Arabia continues to face challenges related to controlling noncommunicable diseases. (NCDs), health disparities, and behavioral factors. This study aims to explore global best practices for improving life expectancy and establish recommendations for Saudi policy makers in the health industry and related stakeholders.</div></div><div><h3>Methodology</h3><div>A robust comparative analysis was used to evaluate the impact of global best practices with respect to the accessibility, efficiency and affordability of different national healthcare systems. It also addresses social determinants of health. Moreover, it looks at national health policies and preventative measures. The primary data sources used include peer-reviewed literature databases such as PubMed, the Lancet and Springer. The data were also derived from reports of global health organizations, such as the WHO, World Bank and OECD publications. The key indicators analysed included healthcare access, cultural/social awareness, education, nutrition, lifestyle, and socioeconomic factors. An online comprehensive questionnaire was sent to analyse data collected from people currently living in the Kingdom of Saudi Arabia.</div></div><div><h3>Results</h3><div>We introduce several recommendations after looking into countries with high longevity rates. <strong>We highlight</strong> the need to adopt evidence-based practices to increase life expectancy in Saudi Arabia. New strategies promoting healthy lifestyles through education, regulating unhealthy products, promoting regular physical activity, integrating mental health into primary health, encouraging plant-based diets and improving preventive healthcare are needed. To achieve a healthier and longer-living population aligning with the Kingdom's vision, cultural and socioeconomic barriers should be further addressed by incorporating stress management practices.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Informal caregivers of older adults, particularly those in their 30s–50 s, often experience stress and lower level of well-being compared to those in other age groups. Considering their crucial role and the challenges they face, there is an increasing need for targeted interventions to support their well-being. To address this, we developed a novel intervention using an online positive psychoeducational program for these caregivers. This study aimed to develop and evaluate the effect of this program on the subjective well-being and quality of life (QOL) through a randomized controlled trial (RCT) to refine the intervention and research delivery.
Methods
This program was developed following the Intervention Mapping (IM) framework for intervention development, comprising six stages. The program consisted of eight sessions delivered over two months. The trial is designed as a two-arm RCT with balanced randomization of 350:150, where participants will either participate in the online-based psychoeducational program or receive a leaflet summarizing the program's contents after all surveys are completed, for a 1:1 ratio of participants who complete the program. The primary outcome measure is the subjective well-being of informal caregivers. Secondary outcomes include QOL, authenticity, self-compassion, strength knowledge, strength use, resilience, loneliness, emotional exhaustion and caregiver burden.
Discussion
This study aims to evaluate the effectiveness of an online intervention program and to evaluate mechanisms of change, and contextual factors that could potentially affect its implementation and outcomes. If proven effectiveness, this program can contribute to new methods that enhance subjective well-being of informal caregivers of older adults.
Trial registration
UMIN Clinical Trials Registry (UMIN000056353); registration date: December 6, 2024.
{"title":"\"Caring for Oneself Program\": Protocol for a randomized controlled trial of an online positive psychoeducational intervention for informal caregivers of older adults","authors":"Akemi Matsuzawa , Yoko Moriyama , Tomoko Wakui , Manami Ochi , Hideto Takahashi","doi":"10.1016/j.aggp.2025.100162","DOIUrl":"10.1016/j.aggp.2025.100162","url":null,"abstract":"<div><h3>Background</h3><div>Informal caregivers of older adults, particularly those in their 30s–50 s, often experience stress and lower level of well-being compared to those in other age groups. Considering their crucial role and the challenges they face, there is an increasing need for targeted interventions to support their well-being. To address this, we developed a novel intervention using an online positive psychoeducational program for these caregivers. This study aimed to develop and evaluate the effect of this program on the subjective well-being and quality of life (QOL) through a randomized controlled trial (RCT) to refine the intervention and research delivery.</div></div><div><h3>Methods</h3><div>This program was developed following the Intervention Mapping (IM) framework for intervention development, comprising six stages. The program consisted of eight sessions delivered over two months. The trial is designed as a two-arm RCT with balanced randomization of 350:150, where participants will either participate in the online-based psychoeducational program or receive a leaflet summarizing the program's contents after all surveys are completed, for a 1:1 ratio of participants who complete the program. The primary outcome measure is the subjective well-being of informal caregivers. Secondary outcomes include QOL, authenticity, self-compassion, strength knowledge, strength use, resilience, loneliness, emotional exhaustion and caregiver burden.</div></div><div><h3>Discussion</h3><div>This study aims to evaluate the effectiveness of an online intervention program and to evaluate mechanisms of change, and contextual factors that could potentially affect its implementation and outcomes. If proven effectiveness, this program can contribute to new methods that enhance subjective well-being of informal caregivers of older adults.</div></div><div><h3>Trial registration</h3><div>UMIN Clinical Trials Registry (UMIN000056353); registration date: December 6, 2024.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 2","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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