Archives of Gerontology and Geriatrics Plus最新文献_第9页

Coronary heart disease racial disparities among older adults in the U.S.: Systematic review, 2000-2024 美国老年人冠心病的种族差异：2000-2024年的系统回顾

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.aggp.2025.100194

Sanggon Nam

Background

Coronary heart disease (CHD) remains a leading cause of morbidity and mortality among older U.S. adults, with significant racial and ethnic disparities in prevalence, treatment, and outcomes. This systematic review synthesizes evidence from 44 studies published between 2000 and 2024 to examine these disparities among adults aged ≥65, focusing on prevalence, access to care, treatment quality, outcomes, contributing factors, and effective interventions.

Methods

The review adhered to PRISMA 2020 guidelines. A comprehensive search was conducted across six databases: PubMed, Embase, Scopus, Web of Science, CINAHL, and the Cochrane Library. Studies were included if they examined racial/ethnic differences in CHD among U.S. adults aged ≥65. Two independent reviewers screened titles and abstracts, followed by full-text review, with disagreements resolved by a third reviewer. Inter-rater reliability was assessed using Cohen’s kappa (0.85 for title/abstract, 0.90 for full-text). Quality assessment used the Newcastle-Ottawa Scale (NOS; high quality ≥7 points, moderate 4–6 points, low ≤3 points) for observational studies and the Cochrane Risk of Bias tool for randomized trials. Due to heterogeneity, a narrative synthesis was conducted, with subgroup analyses for key outcomes.

Results

The 44 included studies revealed persistent disparities in CHD prevalence, access, treatment, and outcomes, particularly affecting Black, Hispanic, and American Indian/Alaska Native (AI/AN) older adults. Minority groups exhibited higher CHD prevalence and risk factors (e.g., hypertension, diabetes), lower access to guideline-directed therapies, and worse outcomes, including higher readmission and mortality rates. Structural racism, socioeconomic factors, and systemic biases were key drivers. Interventions like policy reforms, community-based programs, and telehealth showed promise in reducing disparities.

Conclusions

Despite progress in acute care, significant disparities persist in long-term CHD management among minority older adults. Addressing social determinants, improving access to equitable care, and implementing culturally competent interventions are essential for health equity.

背景冠心病（CHD）仍然是美国老年人发病和死亡的主要原因，在患病率、治疗和结局方面存在明显的种族和民族差异。本系统综述综合了2000年至2024年间发表的44项研究的证据，以检查65岁以上成年人的这些差异，重点关注患病率、获得护理、治疗质量、结果、影响因素和有效干预措施。方法遵循PRISMA 2020指南。在六个数据库中进行了全面的搜索：PubMed， Embase, Scopus, Web of Science， CINAHL和Cochrane图书馆。如果研究在年龄≥65岁的美国成年人中检查了冠心病的种族/民族差异，则纳入研究。两位独立审稿人筛选标题和摘要，然后进行全文审稿，分歧由第三位审稿人解决。评估者间信度采用Cohen’s kappa（标题/摘要0.85，全文0.90）。质量评估采用纽卡斯尔-渥太华量表(NOS；高质量≥7分，中等4-6分，低质量≤3分)的观察性研究和随机试验的Cochrane偏倚风险工具。由于异质性，我们进行了叙事综合，并对关键结果进行了亚组分析。结果纳入的44项研究揭示了冠心病患病率、可及性、治疗和结局方面的持续差异，特别是对黑人、西班牙裔和美国印第安人/阿拉斯加原住民（AI/AN）老年人的影响。少数群体表现出更高的冠心病患病率和危险因素（如高血压、糖尿病），更少获得指导治疗，结果更差，包括更高的再入院率和死亡率。结构性种族主义、社会经济因素和系统性偏见是主要驱动因素。政策改革、社区项目和远程医疗等干预措施有望减少差距。结论：尽管在急症护理方面取得了进展，但少数民族老年人长期冠心病管理方面仍存在显著差异。解决社会决定因素，改善获得公平保健的机会，并实施具有文化竞争力的干预措施，对卫生公平至关重要。

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引用次数: 0

Health on the move: cardiovascular disease risk among ageing male migrants in India 流动中的健康：印度老年男性移民患心血管疾病的风险

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.aggp.2025.100196

Vasim Ahamad , Ujjwal Das

Background

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally, with a growing burden in low- and middle-income countries such as India. Rapid urbanization, lifestyle changes, and demographic shifts have made internal migration a critical determinant of health. The present study aims to investigate the association between migration and CVD among older males in India.

Methods

Data were drawn from the Longitudinal Aging Study in India (LASI Wave-1), including 29,944 male respondents aged 45 years and above. Descriptive statistics, multivariate logistic regression, and Fairlie decomposition analysis were employed to analyze the association between migration and self-reported CVD. Migration streams were categorized as rural–rural, rural–urban, urban–rural, and urban–urban.

Results

Migrants had significantly higher odds of CVD compared to non-migrants (Adjusted OR: 1.12, 95% CI: 1.05–1.19). Migration streams involving urban exposure (rural–urban and urban–urban) were associated with a higher CVD risk. Longer duration of stay at the destination, inter-state and early-life migration were also associated with increased CVD risk. Urban residence, higher education, better economic status, and being unemployed were independently associated with elevated CVD risk. Fairlie decomposition showed that 81% of the CVD disparity between migrants and non-migrants could be explained by observed factors, with place of residence (50.25%), education (18.85%), and MPCE quintile (9.23%) being the major contributors.

Conclusion

Migration, particularly to or within urban areas, is significantly associated with increased CVD risk among older Indian males. The findings underscore the need for public health policies that address urban lifestyle risks and improve health monitoring and preventive care for migrant populations.

背景心血管疾病（CVD）仍然是全球发病率和死亡率的主要原因，在印度等低收入和中等收入国家造成的负担越来越重。快速城市化、生活方式的改变和人口结构的变化使国内移徙成为健康的关键决定因素。本研究旨在调查印度老年男性移民与心血管疾病之间的关系。方法数据来自印度纵向老龄化研究（LASI Wave-1），包括29,944名45岁及以上的男性受访者。采用描述性统计、多元逻辑回归和费尔利分解分析分析迁移与自报CVD之间的关系。迁移流分为农村-农村、农村-城市、城乡和城市-城市。结果移民患心血管疾病的几率明显高于非移民（调整OR: 1.12, 95% CI: 1.05-1.19）。涉及城市暴露的移民流（农村-城市和城市-城市）与较高的心血管疾病风险相关。在目的地停留时间较长、州际迁移和生命早期迁移也与心血管疾病风险增加有关。城市居住、高等教育、较好的经济地位和失业与心血管疾病风险升高独立相关。费尔利分解结果表明，81%的迁移人口与非迁移人口的CVD差异可以用观测因子来解释，其中居住地（50.25%）、教育程度（18.85%）和MPCE五分位数（9.23%）是主要的影响因素。结论：移民，特别是到城市地区或在城市地区的移民，与印度老年男性心血管疾病风险增加显著相关。研究结果强调，需要制定公共卫生政策，解决城市生活方式风险，并改善对流动人口的健康监测和预防保健。

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引用次数: 0

Examining early adversities, demographic, health and psychosocial factors associated with lifetime depression among older Canadians: Findings from a nationally representative study 调查与加拿大老年人终生抑郁相关的早期逆境、人口、健康和社会心理因素：一项具有全国代表性的研究结果

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-07-12 DOI: 10.1016/j.aggp.2025.100187

Megha Goel , Esme Fuller-Thomson

Purpose

Depression among older adults is associated with greater negative physical health, social, and economic outcomes than in younger populations. The objective of this study was to examine factors associated with lifetime depression in a nationally representative sample of Canadian older adults, highlighting characteristics linked to both vulnerability and resilience.

Methods

Secondary analysis of the 2022 Mental Health Access to Care Survey (MHACS) was conducted to estimate the prevalence and factors associated with lifetime depression among adults aged 55 and older (n = 3,535). The MHACS measured depression using the World Health Organization’s Composite International Diagnostic Interview (WHO-CIDI). Multivariable logistic regression of lifetime depression was conducted analyzing demographic and socioeconomic variables, adverse childhood experiences, physical health measures, health behaviors, and protective psychosocial factors.

Results

One in eleven older adults (9.2%) had experienced depression at some point in their lives. Middle-aged adults (55–64 years) compared to older respondents, and females compared to males had twice the odds of lifetime depression. Other factors associated with depression included childhood physical or sexual abuse, higher educational attainment, history of substance use disorders, multiple chronic physical health conditions, lower sense of life meaning, and higher spirituality.

Conclusion

Lifetime depression in older adults is associated with a complex interplay of risk and protective factors. Identifying these factors can support early recognition and targeted intervention, potentially improving outcomes and quality of life in this population.

目的：与年轻人群相比，老年人抑郁症对身体健康、社会和经济的负面影响更大。本研究的目的是在具有全国代表性的加拿大老年人样本中检查与终生抑郁症相关的因素，突出与脆弱性和适应力相关的特征。方法对2022年心理健康可及性保健调查（MHACS）进行二次分析，估计55岁及以上成年人（n = 3535）终生抑郁的患病率和相关因素。MHACS使用世界卫生组织的综合国际诊断访谈（WHO-CIDI）来测量抑郁症。对终生抑郁症的人口统计学和社会经济变量、不良童年经历、身体健康措施、健康行为和保护性心理社会因素进行多变量logistic回归分析。结果每11个老年人中就有一个（9.2%）在他们生命中的某个阶段经历过抑郁症。中年人（55-64岁）患抑郁症的几率是老年人的两倍，女性患抑郁症的几率是男性的两倍。与抑郁症相关的其他因素包括童年时期的身体虐待或性虐待、较高的教育程度、物质使用障碍史、多种慢性身体健康状况、较低的生活意义感和较高的灵性。结论老年人终生抑郁与危险因素和保护因素的复杂相互作用有关。识别这些因素可以支持早期识别和有针对性的干预，潜在地改善这一人群的预后和生活质量。

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引用次数: 0

Reflections of those who have lived: Phenomenological perspectives from adults at end-of-life from an Eriksonian lens 对那些曾经生活过的人的反思：从埃里克森的视角看成年人在生命末期的现象学视角

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.1016/j.aggp.2025.100175

Brittany Stahnke , Roxxi Davis , Morgan Cooley , Porsha Farmer

There is little research focused on the knowledge that those in the last stage of their lives can offer. The last phase of life brings with it unique wisdom and life advice that can be used to guide all people in their journeys. The purpose of this study was to provide scholarship detailing advice and learnings of those in this unique and final life stage. Nine participants were interviewed in the year 2021, and transcripts were analyzed in an interpretative phenomenological manner. Main themes of life suffering and values presented with sub-themes including illness, loss, family, faith, and purpose. The importance of choice in the lives we live, as well as hard work supports the abilities to succeed in valued areas. Family was stated to be the most important part of these lives; however, with or without family, one also benefits from a sense of accomplishment and pride in themselves.

很少有研究关注那些处于生命最后阶段的人能提供什么知识。人生的最后阶段带来了独特的智慧和人生建议，可以用来指导所有人的旅程。这项研究的目的是为那些处于这个独特的最后生命阶段的人提供详细的建议和学习。在2021年对9名参与者进行了采访，并以解释现象学的方式分析了成绩单。主要主题是生活的痛苦和价值，次主题包括疾病，失去，家庭，信仰和目的。我们生活中选择的重要性，以及努力工作支持我们在有价值的领域取得成功的能力。家庭被认为是这些人生活中最重要的部分；然而，不管有没有家庭，一个人也会从成就感和自豪感中受益。

引用次数: 0

Global research trends on subtypes of Parkinson's disease: A visual bibliometric analysis 帕金森氏病亚型的全球研究趋势：视觉文献计量分析

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-05-07 DOI: 10.1016/j.aggp.2025.100166

Yan Su , Sheng Cai , Yang Xu , Xianwen Chen

Object

Parkinson's disease (PD) is a neurodegenerative disease with different subtypes. More accurate subtype classification is significant for understanding the pathogenesis of PD, predicting disease progression, and selecting effective treatment methods. A bibliometric analysis of relevant research on PD subtypes is presented in this study.

Methods

Original research and review articles related to PD subtypes from January 1, 2015 to December 31, 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. After screening, 2213 articles were obtained. Statistical analysis and visualization of country, institution, author, journal, and keyword information contained in the studies were performed using CiteSpace (v6.2. R4) and VOSviewer (v1.6.20.0) software to identify research hotspots and trends in the field.

Result

The 2213 articles used in this study were from 11740 authors from 3117 institutions in 93 countries and published in 481 journals. From the analysis, it was found that the number of annual publications in this field has been increasing year by year in the past 10 years. The United States contributed the most to this research direction, with the largest number of publications (604) and citations (31, 284), and the strongest connection with other countries. 'Motor disorder ' is the most frequently cited journal, and ' Parkinson 's disease-related disorder ' is the most frequently published journal. "Parkinson's Disease", "Dementia", "Subtypes", and "Progress" are frequently used keywords, while "Rem sleep", "networs", and "machine learning" are the focus of research in recent years.

Conclusion

The bibliometric analysis offers a comprehensive insight into present research focal points and evolving patterns associated with PD subtypes. High-frequency keywords pinpointed underscore dynamic research fields encompassing methodologies, mechanisms, and engaged populations. These findings can provide guidance for future research on PD subtypes.

目的帕金森病（PD）是一种具有不同亚型的神经退行性疾病。更准确的亚型分类对于了解PD的发病机制，预测疾病进展，选择有效的治疗方法具有重要意义。本文对PD亚型的相关研究进行文献计量学分析。方法从Web of Science Core Collection （WOSCC）数据库中检索2015年1月1日至2024年12月31日与PD亚型相关的原始研究和综述文章。经筛选，得到2213篇。使用CiteSpace （v6.2）对研究中包含的国家、机构、作者、期刊和关键字信息进行统计分析和可视化。R4)和VOSviewer （v1.6.20.0）软件，识别该领域的研究热点和趋势。结果本研究共纳入来自93个国家3117个机构的11740位作者的2213篇文献，发表于481种期刊。通过分析发现，近10年来，该领域的年度出版物数量逐年增加。美国对这一研究方向的贡献最大，发表论文604篇，被引用次数31,284次，与其他国家联系最紧密。“运动障碍”是最常被引用的期刊，“帕金森病相关障碍”是最常发表的期刊。“帕金森病”、“痴呆”、“亚型”、“进展”是频繁使用的关键词，而“Rem睡眠”、“网络”、“机器学习”是近年来的研究热点。结论文献计量学分析提供了对当前研究重点和PD亚型相关演变模式的全面洞察。精确的高频关键词强调了包括方法、机制和参与人群在内的动态研究领域。这些发现可以为今后PD亚型的研究提供指导。

{"title":"Global research trends on subtypes of Parkinson's disease: A visual bibliometric analysis","authors":"Yan Su , Sheng Cai , Yang Xu , Xianwen Chen","doi":"10.1016/j.aggp.2025.100166","DOIUrl":"10.1016/j.aggp.2025.100166","url":null,"abstract":"<div><h3>Object</h3><div>Parkinson's disease (PD) is a neurodegenerative disease with different subtypes. More accurate subtype classification is significant for understanding the pathogenesis of PD, predicting disease progression, and selecting effective treatment methods. A bibliometric analysis of relevant research on PD subtypes is presented in this study.</div></div><div><h3>Methods</h3><div>Original research and review articles related to PD subtypes from January 1, 2015 to December 31, 2024 were retrieved from the Web of Science Core Collection (WOSCC) database. After screening, 2213 articles were obtained. Statistical analysis and visualization of country, institution, author, journal, and keyword information contained in the studies were performed using CiteSpace (v6.2. R4) and VOSviewer (v1.6.20.0) software to identify research hotspots and trends in the field.</div></div><div><h3>Result</h3><div>The 2213 articles used in this study were from 11740 authors from 3117 institutions in 93 countries and published in 481 journals. From the analysis, it was found that the number of annual publications in this field has been increasing year by year in the past 10 years. The United States contributed the most to this research direction, with the largest number of publications (604) and citations (31, 284), and the strongest connection with other countries. 'Motor disorder ' is the most frequently cited journal, and ' Parkinson 's disease-related disorder ' is the most frequently published journal. \"Parkinson's Disease\", \"Dementia\", \"Subtypes\", and \"Progress\" are frequently used keywords, while \"Rem sleep\", \"networs\", and \"machine learning\" are the focus of research in recent years.</div></div><div><h3>Conclusion</h3><div>The bibliometric analysis offers a comprehensive insight into present research focal points and evolving patterns associated with PD subtypes. High-frequency keywords pinpointed underscore dynamic research fields encompassing methodologies, mechanisms, and engaged populations. These findings can provide guidance for future research on PD subtypes.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The scope of frailty assessment tools in the middle east: unraveling gaps and trends 中东脆弱性评估工具的范围：揭示差距和趋势

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-05-17 DOI: 10.1016/j.aggp.2025.100168

Sulaiman Alshakhs M.D., Sara Mohamed, Ibtihal Kamal, Sa'ad Laws, Mai A. Mahmoud MBBS, MEHP

Background

Frailty is a multidimensional syndrome associated with increased risk of adverse health outcomes in older adults. As Middle Eastern populations age, validated frailty assessment tools (FATs) are essential to inform care planning. However, regional uptake and validation remain unclear.

Objective

This scoping review aimed to map the use and validation of FATs among adults aged 55 and above in the Middle East, identify research gaps, and explore cross-country trends.

Methods

Following PRISMA-ScR guidelines, a comprehensive literature search was conducted in May 2022 and updated in December 2024 across PubMed, Embase, Web of Science, and Scopus. Search terms targeted “frailty,” “geriatric,” and 17 Middle Eastern countries. Inclusion criteria comprised primary studies using or discussing FATs among adults aged 55+, conducted in or including a Middle Eastern country. Non-English/Arabic texts, non-primary literature, and studies lacking frailty definitions or tools were excluded. In total, 103 studies were included.

Results

The Clinical Frailty Scale (CFS) and Fried Frailty Phenotype (FFP) were the most commonly used tools, appearing in 36 and 32 studies respectively. However, only 12 studies reported tool validation, and just 7 conducted cultural adaptation. Research output was highest in Turkey (28 studies), Iran (17), and Saudi Arabia (14), while 6 countries had no studies. Most studies used FATs in hospital settings.

Conclusion

Frailty research is growing in the Middle East but remains fragmented and under-validated. Standardized tools adapted to local contexts are urgently needed. Strengthening clinical care and policy will require greater regional collaboration and investment in culturally relevant research

背景：虚弱是一种多维综合征，与老年人不良健康结局风险增加相关。随着中东人口的老龄化，经过验证的衰弱评估工具（fat）对于为护理规划提供信息至关重要。然而，区域吸收和验证仍不清楚。目的：本综述旨在绘制中东地区55岁及以上成年人中脂肪的使用和验证图，确定研究空白，并探索跨国趋势。方法遵循PRISMA-ScR指南，于2022年5月对PubMed、Embase、Web of Science和Scopus进行了全面的文献检索，并于2024年12月进行了更新。搜索词的目标是“虚弱”、“老年”和17个中东国家。纳入标准包括在中东国家或包括中东国家进行的55岁以上成年人中使用或讨论脂肪的初步研究。非英语/阿拉伯语文本、非主要文献和缺乏脆弱性定义或工具的研究被排除在外。总共纳入103项研究。结果临床虚弱量表（CFS）和油炸虚弱表型（FFP）是最常用的评估工具，分别出现在36项和32项研究中。然而，只有12项研究报告了工具验证，只有7项研究进行了文化适应。研究产出最高的是土耳其（28篇）、伊朗（17篇）和沙特阿拉伯（14篇），6个国家没有研究。大多数研究在医院环境中使用脂肪。结论衰弱研究在中东地区正在增长，但仍然是碎片化和缺乏验证的。迫切需要适应当地情况的标准化工具。加强临床护理和政策将需要在文化相关研究方面加强区域合作和投资

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引用次数: 0

A UK study: Menopausal and perimenopausal women’s biopsychosocial experiences, understanding of treatment options, and thoughts towards their future lives 英国的一项研究：绝经期和围绝经期妇女的生物心理社会经历，对治疗方案的理解，以及对未来生活的看法

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-07-27 DOI: 10.1016/j.aggp.2025.100191

Mandy Simpson, Cynthia Tuuli, Elizabeth Eate

Objective

This study aimed to draw attention and give voice to women’s experiences, knowledge, future thoughts and general understanding of perimenopause and menopause, exploring this natural event holistically through a biopsychosocial lens.

Methods

One focus group of four self-identified perimenopausal or menopausal women was conducted to gather data. Purposive sampling was used to recruit the participants through a social media campaign. Interpretative Phenomenological Analysis provided a framework to study this important topic through exploring and examining lived experiences in a small group sample size, using the framework’s seven-step data analysis to identify key themes within the data.

Results

Four main group experiential themes were highlighted through analysis of the participants' responses: (1) onset and impact of symptoms, (2) menopause and relationships, (3) the knowledge gap, and (4) future thoughts: a desire for change. A prominent overarching theme involved the participants showing less concern for how they were being personally affected by their climacteric experience but demonstrating greater concern for the impact of their perimenopause or menopause experience upon others. This overarching theme was evident within all four group experiential themes.

Conclusions

The participants were deeply concerned about how their symptoms affected others. They had limited knowledge when their own symptoms started, but after seeking support, particularly from people with lived experiences rather than academic literature, they became inspired to be a part of bringing about change for the next generation, so that in the future menopause experiences would not occur so unexpectedly for others.

目的探讨女性对围绝经期和绝经期的经历、认识、未来思考和总体认识，并从生物心理社会的角度对这一自然事件进行全面探讨。方法对4名自我认定为围绝经期或绝经期妇女进行焦点小组调查，收集资料。有目的的抽样是通过社交媒体活动来招募参与者。解释性现象学分析提供了一个框架，通过在小样本中探索和检查生活经验来研究这一重要主题，使用该框架的七步数据分析来确定数据中的关键主题。结果通过对参与者反应的分析，突出了四个主要的小组体验主题：(1)症状的发生和影响，(2)更年期和关系，(3)知识差距，(4)未来的想法：改变的愿望。一个突出的总体主题是，参与者对自己的更年期经历如何影响个人表现出较少的关注，但对自己的围绝经期或更年期经历对他人的影响表现出更多的关注。这一总体主题在所有四组体验主题中都很明显。参与者非常关心他们的症状如何影响他人。当她们自己的症状开始出现时，她们的知识有限，但在寻求支持后，特别是从有实际经历的人那里寻求支持，而不是从学术文献中寻求支持，她们受到鼓舞，成为为下一代带来改变的一部分，这样在未来，更年期的经历就不会如此出乎意料地发生在其他人身上。

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引用次数: 0

Gender differences in disability among older persons in India: Evidence from the longitudinal ageing study in India (LASI) 印度老年人残疾的性别差异：来自印度纵向老龄化研究的证据

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-06-21 DOI: 10.1016/j.aggp.2025.100183

Kinkar Mandal PhD (Assistant Professor) , Lekha Subaiya PhD (Professor)

Background

Older women experience higher rates of disability compared to men. This gender disparity is linked to varying risk factors. The objective of this study is to investigate gender differences in disability among older adults in India

Methods

For this study, we used Longitudinal Ageing Study of India, Wave 1 (2017–2018) data, a nationally representative dataset of older persons age 60 years and above. Both descriptive and inferential statistics are used to analysis the data.

Results

Our findings indicate that older women report higher rates of vision, hearing, difficulty in chewing solid food, and physical disabilities, contributing to the observed gender differences in disability. Among these, vision impairment is the most prevalent. Notably, women with fewer years of schooling and those living in households in the lower wealth quintiles exhibit the highest levels of disability. Additionally, older individuals who are of advanced age, widowed, living in urban areas or alone, currently employed, or who experienced poor childhood health are more likely to report disabilities.

Conclusion

The higher prevalence of disability among women is the result of a combination of demographic and socioeconomic factors. These findings serve as a wake-up call for researchers and policymakers to prioritize gender-sensitive interventions aimed at preventing disability among older adults.

与男性相比，老年女性的残疾率更高。这种性别差异与不同的风险因素有关。本研究的目的是调查印度老年人残疾的性别差异。方法在本研究中，我们使用了印度纵向老龄化研究第一波（2017-2018）数据，这是一个具有全国代表性的60岁及以上老年人数据集。描述性统计和推断性统计都用于分析数据。结果我们的研究结果表明，老年女性在视力、听力、咀嚼固体食物困难和身体残疾方面的比例更高，这是观察到的残疾性别差异的原因。其中，视力障碍最为普遍。值得注意的是，受教育年限较短的妇女和生活在较低财富五分之一家庭的妇女表现出最高的残疾水平。此外，高龄、丧偶、居住在城市地区或独居、目前就业或童年健康状况不佳的老年人更有可能报告残疾。结论妇女残疾患病率较高是人口统计学和社会经济因素共同作用的结果。这些发现为研究人员和政策制定者敲响了警钟，提醒他们优先考虑旨在预防老年人残疾的性别敏感干预措施。

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引用次数: 0

Thyroid-stimulating hormone and cognitive impairment in non-depressed non-demented multiethnic middle-aged and older US adults: Assessing sex-specific risk prediction 促甲状腺激素和非抑郁非痴呆多种族美国中老年成人的认知障碍：评估性别特异性风险预测

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.aggp.2025.100195

Asma Hallab , Alzheimer’s Disease Neuroimaging Initiative

Background

Understanding the particularities of thyroid-cognition interactions in older adults is crucial in assessing the risks and evaluating therapeutic options.

Methods

Cross-sectional analyses where participants from Alzheimer’s Disease Neuroimaging Initiative (ADNI) with mild cognitive impairment (MCI) and healthy controls (HC), with complete neurocognitive tests, thyroid stimulating hormone (TSH) <10 µIU/mL, and geriatric depression scale (GDS) <5, were eligible. Linear and logistic regression models, including testing for non-linearity, were performed. Sex strata were explored.

Results

Of the total 1845 multiethnic US-participants, with a median age of 73 (IQR: 68, 78); 887 (48 %) were females, and 1056 (57 %) had MCI. The median TSH level was 1.70 µIU/mL (IQR: 1.15, 2.40); significantly lower in MCI than HC (1.66 vs. 1.74 µIU/mL, p-value=0.02). There was a significant association between TSH and overall cognition only in males (adj. ß_Males=-0.40[-0.74, -0.07], p-value=0.019). The odds of being diagnosed with MCI at baseline decreased with higher TSH levels in the total study population (adj. OR_Total=0.87[0.79, 0.95], p-value=0.002) and in males (adj. OR_Males=0.80[0.70, 0.92], p-value=0.001).

Conclusions

There was a sex-specific, statistically significant association between TSH levels and cognition in multiethnic middle-aged and older ADNI adults. Lower TSH levels and worse global cognition were statistically associated only in males. To precisely delineate the chronological onset of these disorders, longitudinal clinical studies are needed.

背景了解老年人甲状腺认知相互作用的特殊性对于评估风险和评估治疗方案至关重要。方法采用横断面分析，来自阿尔茨海默病神经影像学计划（ADNI）的轻度认知障碍（MCI）和健康对照（HC）的参与者，进行完整的神经认知测试，促甲状腺激素（TSH） 10 μ IU/mL，老年抑郁量表（GDS） 5。进行了线性和逻辑回归模型，包括非线性检验。对性别阶层进行了探索。结果在总共1845名多种族美国参与者中，中位年龄为73岁（IQR: 68,78）；887例（48%）为女性，1056例（57%）为轻度认知障碍。中位TSH水平为1.70 μ IU/mL (IQR: 1.15, 2.40)；MCI显著低于HC （1.66 vs. 1.74 μ IU/mL， p值=0.02）。TSH与整体认知的相关性仅在男性中存在显著性差异（adi . ß male =-0.40[-0.74, -0.07]， p值=0.019）。随着TSH水平的升高，总体研究人群（adj. ORTotal=0.87[0.79, 0.95]， p值=0.002）和男性（adj. ormale =0.80[0.70, 0.92]， p值=0.001）在基线时被诊断为轻度认知障碍的几率降低。结论多种族中老年ADNI成人TSH水平与认知之间存在性别特异性、统计学意义显著的关联。较低的TSH水平和较差的整体认知仅在男性中有统计学关联。为了准确地描述这些疾病的发病时间，需要进行纵向临床研究。

{"title":"Thyroid-stimulating hormone and cognitive impairment in non-depressed non-demented multiethnic middle-aged and older US adults: Assessing sex-specific risk prediction","authors":"Asma Hallab , Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.aggp.2025.100195","DOIUrl":"10.1016/j.aggp.2025.100195","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the particularities of thyroid-cognition interactions in older adults is crucial in assessing the risks and evaluating therapeutic options.</div></div><div><h3>Methods</h3><div>Cross-sectional analyses where participants from Alzheimer’s Disease Neuroimaging Initiative (ADNI) with mild cognitive impairment (MCI) and healthy controls (HC), with complete neurocognitive tests, thyroid stimulating hormone (TSH) <10 µIU/mL, and geriatric depression scale (GDS) <5, were eligible. Linear and logistic regression models, including testing for non-linearity, were performed. Sex strata were explored.</div></div><div><h3>Results</h3><div>Of the total 1845 multiethnic US-participants, with a median age of 73 (IQR: 68, 78); 887 (48 %) were females, and 1056 (57 %) had MCI. The median TSH level was 1.70 µIU/mL (IQR: 1.15, 2.40); significantly lower in MCI than HC (1.66 vs. 1.74 µIU/mL, <em>p</em>-value=0.02). There was a significant association between TSH and overall cognition only in males (adj. <em>ß</em><sub>Males</sub>=-0.40[-0.74, -0.07], <em>p</em>-value=0.019). The odds of being diagnosed with MCI at baseline decreased with higher TSH levels in the total study population (adj. OR<sub>Total</sub>=0.87[0.79, 0.95], <em>p</em>-value=0.002) and in males (adj. OR<sub>Males</sub>=0.80[0.70, 0.92], <em>p</em>-value=0.001).</div></div><div><h3>Conclusions</h3><div>There was a sex-specific, statistically significant association between TSH levels and cognition in multiethnic middle-aged and older ADNI adults. Lower TSH levels and worse global cognition were statistically associated only in males. To precisely delineate the chronological onset of these disorders, longitudinal clinical studies are needed.</div></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"2 3","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-communicable diseases and risk factors profiling among geriatric population residing in Hyderabad city, India 印度海得拉巴市老年人口的非传染性疾病和风险因素分析

Archives of Gerontology and Geriatrics Plus

Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI: 10.1016/j.aggp.2025.100153

Karthikeyan Ramanujam, Joyeeta Thakur, Rajitha Triveni Koralla, JJ Babu Geddam, Samarasimha Reddy N

Background

India's aging population, expected to reach 340 million by 2050, faces a growing burden of non-communicable diseases (NCDs) like hypertension, diabetes, and obesity.

Objective

In this study, we assessed the prevalence of Non communicable diseases among the elderly population residing in Hyderabad city in India and identified the associated risk factors.

Methods

We conducted a community-based cross-sectional study in an urban locality of Hyderabad city, Telangana state among 1320 elderly individuals aged 60 years and above. Data on anthropometric measurements, dietary intakes, socio-economic factors, and NCD history were collected using structured questionnaires and standardized tools. We have used descriptive statistics to estimate the burden of NCDs and a multivariable logistic regression was used for identifying the associated risk factors.

Results

We observed that among elderly population, 49.9% (95% CI 47.2%-52.6%) had reported hypertension, 25.8% (95% CI 23.5%-28.3%) had diabetes, and 44.3% (41%-47.5%) were obese, with women having notably higher burden for all three conditions. Dietary patterns showed moderate diversity, with only 41.2% elderly population consuming protein-rich foods weekly followed by 74.4% consuming vegetables. Multivariable analysis revealed that individuals with obesity had increased odds of hypertension (AOR 2.59; 95% CI 1.83–3.66) and diabetes (1.65; 95% CI 1.03–2.63) compared to individuals without obesity. The participants with abnormal waist hip ratio were at higher odds of having hypertension (AOR 1.66; 95% CI; 1.03–2.67).

Conclusion

Our findings highlight the significant burden of NCDs among urban elderly, driven by obesity and suboptimal dietary patterns. Public health policies should prioritize focusing on balanced nutrition for control of NCDs among elderly population.

印度的老龄化人口预计到2050年将达到3.4亿，他们面临着越来越多的非传染性疾病（NCDs），如高血压、糖尿病和肥胖。目的评估印度海得拉巴市老年人非传染性疾病的患病率，并确定相关危险因素。方法我们在泰伦加纳邦海德拉巴市的一个城区对1320名60岁及以上的老年人进行了以社区为基础的横断面研究。使用结构化问卷和标准化工具收集了人体测量、饮食摄入量、社会经济因素和非传染性疾病病史的数据。我们使用描述性统计来估计非传染性疾病的负担，并使用多变量逻辑回归来确定相关的风险因素。结果我们观察到，在老年人群中，49.9% （95% CI 47.2%-52.6%）报告有高血压，25.8% （95% CI 23.5%-28.3%）报告有糖尿病，44.3%（41%-47.5%）报告有肥胖，女性在这三种情况下的负担明显更高。老年人的饮食模式表现出适度的多样性，仅41.2%的老年人每周食用富含蛋白质的食物，74.4%的老年人每周食用蔬菜。多变量分析显示，肥胖个体患高血压的几率增加(AOR 2.59；95% CI 1.83-3.66)和糖尿病(1.65；95% CI 1.03-2.63)。腰臀比异常的参与者患高血压的几率更高(AOR 1.66；95%可信区间;1.03 - -2.67)。结论：我们的研究结果强调了非传染性疾病在城市老年人中的显著负担，这是由肥胖和次优饮食模式驱动的。公共卫生政策应优先关注均衡营养，以控制老年人非传染性疾病。

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引用次数: 0