Electrospun scaffolds with aligned fiber orientation are widely used in tissue engineering, such as muscle, heart, nerve, tendon, and cartilage, due to their ability to guide cell morphology and induce cellular functions. However, the dense fibrous structure of the scaffolds poses a critical obstacle to engineering highly cellular and thick 3D tissues, as it prevents cell infiltration. While many techniques have been developed to increase the pore size of electrospun scaffolds and improve cell infiltration/migration, it often leads to a decrease in direct cell-cell contact, compromising cell differentiation and tissue maturation. This study presents an alternative approach by reducing the thickness of scaffolds to the cellular scale and stacking or rolling the cell-scaffold complex into 3D constructs. We devise a series of novel tools to fabricate, characterize, and manipulate ultra-thin electrospun scaffolds, which demonstrate high reproducibility, resolution, and cellularity. Our study provides a solution to the cell infiltration issue in muscle tissue engineering and is highly versatile, and can be applied to various fields that require structures with high-resolution gradients in a layered pattern or complex spatial distribution in a rolled pattern.
{"title":"Thickening tissue by thinning electrospun scaffolds for skeletal muscle tissue engineering","authors":"Shuo Wang, Xinhuan Wang, Minxuan Jia, Wenli Liu, Qi Gu","doi":"10.1002/bmm2.12084","DOIUrl":"10.1002/bmm2.12084","url":null,"abstract":"<p>Electrospun scaffolds with aligned fiber orientation are widely used in tissue engineering, such as muscle, heart, nerve, tendon, and cartilage, due to their ability to guide cell morphology and induce cellular functions. However, the dense fibrous structure of the scaffolds poses a critical obstacle to engineering highly cellular and thick 3D tissues, as it prevents cell infiltration. While many techniques have been developed to increase the pore size of electrospun scaffolds and improve cell infiltration/migration, it often leads to a decrease in direct cell-cell contact, compromising cell differentiation and tissue maturation. This study presents an alternative approach by reducing the thickness of scaffolds to the cellular scale and stacking or rolling the cell-scaffold complex into 3D constructs. We devise a series of novel tools to fabricate, characterize, and manipulate ultra-thin electrospun scaffolds, which demonstrate high reproducibility, resolution, and cellularity. Our study provides a solution to the cell infiltration issue in muscle tissue engineering and is highly versatile, and can be applied to various fields that require structures with high-resolution gradients in a layered pattern or complex spatial distribution in a rolled pattern.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.
This should be corrected to “Xing-Jie Liang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”
{"title":"Correction to “Ferritin-based drug delivery system for tumor therapy”","authors":"","doi":"10.1002/bmm2.12092","DOIUrl":"10.1002/bmm2.12092","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.</p><p>This should be corrected to “Xing-Jie Liang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.
This should be corrected to “Changyong Wang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”
{"title":"Correction to “Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases”","authors":"","doi":"10.1002/bmm2.12094","DOIUrl":"10.1002/bmm2.12094","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.</p><p>This should be corrected to “Changyong Wang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for the error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.
This should be corrected to “Changyou Gao is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interest.”
{"title":"Correction to “Prosthetic heart valves for transcatheter aortic valve replacement”","authors":"","doi":"10.1002/bmm2.12097","DOIUrl":"10.1002/bmm2.12097","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.</p><p>This should be corrected to “Changyou Gao is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interest.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflict of interest.” is incomplete.
This should be corrected to “Yanglong Hou is an editorial board member of BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”
{"title":"Correction to “Intelligent micro/nanorobots for improved tumor therapy”","authors":"","doi":"10.1002/bmm2.12095","DOIUrl":"10.1002/bmm2.12095","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflict of interest.” is incomplete.</p><p>This should be corrected to “Yanglong Hou is an editorial board member of BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for the error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflict of interest.” is incomplete.
This should be corrected to “Wei Huang and Xiaocheng Dong are the editorial board member of BMEMat journal and were not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”
{"title":"Correction to “Photo-facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications”","authors":"","doi":"10.1002/bmm2.12091","DOIUrl":"10.1002/bmm2.12091","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflict of interest.” is incomplete.</p><p>This should be corrected to “Wei Huang and Xiaocheng Dong are the editorial board member of BMEMat journal and were not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflict of interest.” is incomplete.
This should be corrected to “Guangjun Nie is an editorial board member of BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”
{"title":"Correction to “Current advances in non-viral gene delivery systems: Liposomes versus extracellular vesicles”","authors":"","doi":"10.1002/bmm2.12093","DOIUrl":"10.1002/bmm2.12093","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflict of interest.” is incomplete.</p><p>This should be corrected to “Guangjun Nie is an editorial board member of BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for the error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.
This should be corrected to “Qiangbin Wang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interests.”
{"title":"Correction to “Advanced near-infrared light approaches for neuroimaging and neuromodulation”","authors":"","doi":"10.1002/bmm2.12098","DOIUrl":"10.1002/bmm2.12098","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.</p><p>This should be corrected to “Qiangbin Wang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interests.”</p><p>We apologize for the error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.
This should be corrected to “Dong Ming is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interests.”
{"title":"Correction to “Aconitum carmichaelii triggers neurotoxicity and Parkinson-like symptoms through initiation of ROS-mitochondrial apoptosis and the Nox5/DJ-1 signaling pathway”","authors":"","doi":"10.1002/bmm2.12099","DOIUrl":"10.1002/bmm2.12099","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no competing financial interests.” is incomplete.</p><p>This should be corrected to “Dong Ming is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing financial interests.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.
This should be corrected to “Xian Jun Loh is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”
We apologize for this error.
在 "利益冲突声明 "部分，"作者声明无利益冲突 "的文字不完整，应更正为 "Xian Jun Loh 是 BMEMat 杂志的编辑委员会成员，并未参与本文的编辑审核或发表决定。所有作者声明不存在利益冲突。"我们对此错误深表歉意。
{"title":"Correction to “Responsive hydrogel dressings for intelligent wound management”","authors":"","doi":"10.1002/bmm2.12096","DOIUrl":"10.1002/bmm2.12096","url":null,"abstract":"<p>In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.</p><p>This should be corrected to “Xian Jun Loh is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”</p><p>We apologize for this error.</p>","PeriodicalId":100191,"journal":{"name":"BMEMat","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmm2.12096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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