BMEMat最新文献

Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the joints. Herein, we developed a biomimetic formulation via co-loading the anti-inflammatory agent Celastrol (Cel) along with the stabilizer Vitamin K (VK) in antirheumatic methotrexate (MTX)-conjugated Pluronic F127 (F127) micelles. Micelles were then coated with B cell derived membrane, yielding MTX loaded Cel Micelle (CeViM)-micelle@B, which were investigated for RA treatment. VK, used at levels well within safety margins, was identified as a carrier compound that could stabilize Cel within micelles, increasing the encapsulation efficiency of Cel. In addition, MTX, a front-line RA therapeutic, was chemically grafted to F127 via a responsive linker sensitive to the chemically reducing environments. As such, CeViM-micelle@B released pristine MTX in response to the intracellular reducing environments, which combined with Cel to suppress pro-inflammatory responses. B cell membrane coating enhanced accumulation of CeViM-micelle@B in joints, leading to a 75% decrease of inflammatory cytokine secretion in vitro, and significantly ameliorated cartilage and bone structures in the collagen-induced arthritis murine model. Taken together, this biomimetic nanoparticle holds potential as a next-generation targeted RA treatment.

Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost, morbidity, and even mortality. This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials. The forms of manufacturing and synthesizing hybrid coatings were first discussed. We then categorize these coatings based on their biological functions: antibacterial coatings, which are essential for preventing difficult-to-treat infection; coatings designed to promote osseointegration, crucial for the mechanical stability of implants; coatings that encourage soft tissue attachment, contributing to the overall success and esthetics of implant. We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative, holistic approach for reducing implant complications. The review culminates in a discussion on future directions in the field, emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients. Together, our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.

In this article number 10.1002/bmm2.12077, Guiqiang Zhang, Ning Wang and their co-workers developed stimulator of interferon genes (STING)-activating nanoparticles via metal coordination-driven assembly of a synthetic STING agonist and a phenolic chemotherapeutic drug. These nanoparticles could efficiently accumulate in tumors, leading to potent STING pathway activation, induction of immunogenic cell death, and regulation of amino acid metabolism. The antitumor immunity induced by nanoparticles could significantly inhibit the growth of primary, recurrent, and metastatic tumors, providing a novel paradigm for tumor chemo-immunotherapy.

Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines have been timely, concisely and fully discussed in this article number 10.1002/bmm2.12067, with an outlook on the current challenges and potential solutions.

With high biocompatibility and degradability, polysaccharide-based hydrogels are favorable healthcare materials. However, in many biomedical applications, these materials are inconvenient to handle with fixed morphology, unable to closely match the wounds, and easy to detach due to insufficient adhesion. Inspired by the superior wet adhesive properties of marine mussels, researchers have used mussel-inspired chemistry to create mussel-mimetic injectable polysaccharide-based hydrogels that are simple to operate, controllable in shape, and highly adhesive, and have significantly extended their applications such as tissue adhesives, delivery vehicles, tissue engineering scaffolds, and wearable sensors. However, there are few comprehensive reviews on polysaccharide-based hydrogels with both mussel-mimetic adhesion and injectability, and few critical analyses of these hydrogels' preparation methods and applications. This review fills this gap and systematically summarizes the preparation strategies for novel mussel-mimetic injectable polysaccharide-based hydrogels, including modifying polysaccharides with catechol- or pyrogallol-containing small molecules and leveraging different interactions between catechol-/pyrogallol-modified polysaccharides and other substances to form crosslinked hydrogels. Furthermore, recent biomedical applications of injectable catechol-/pyrogallol-modified polysaccharide-based hydrogels are discussed, and their future challenges and research trends are proposed.

Photothermal lanthanide nanomaterials with unique photophysical properties have been innovatively explored for diagnostics and non-invasive therapies, and hold great promise for precision theranostics. In this review, we start from the basic principles of excited-state dynamics and provide a thorough comprehension of the main pathways for photothermal conversion in lanthanide nanocrystals. Aspects influencing the photothermal effect such as lanthanide-doping concentration, particle size, and crystal structure have been fully discussed. Hybrid strategies for the design of efficient lanthanide-based photothermal agents, including dye sensitization to break the absorption limit and semiconductor combination to add cross-relaxation pathways, have also been summarized. Furthermore, we highlight the cutting-edge applications of photothermal lanthanide nanoplatforms with optical diagnosis and temperature feedback in photothermia-associated theranostics. Lastly, the current challenges and future efforts for clinical applications are proposed. This review is expected to offer a better understanding of photothermal mechanisms and inspire efforts for designing versatile lanthanide theranostic nanoplatforms.

By innovatively coupling human body and functional fibers, recent inspiring research achieves radiation energy capture, signal transmission and digital visualization while retains flexibilities, softness and durability of textiles and their large-scale fabrications. The single coupled human-fiber system provides absolutely new mechanism and fibrous method to design and produce intelligent textiles and promises to offer more potential applications in home and daily lives.

Electrospun scaffolds with aligned fiber orientation are widely used in tissue engineering, such as muscle, heart, nerve, tendon, and cartilage, due to their ability to guide cell morphology and induce cellular functions. However, the dense fibrous structure of the scaffolds poses a critical obstacle to engineering highly cellular and thick 3D tissues, as it prevents cell infiltration. While many techniques have been developed to increase the pore size of electrospun scaffolds and improve cell infiltration/migration, it often leads to a decrease in direct cell-cell contact, compromising cell differentiation and tissue maturation. This study presents an alternative approach by reducing the thickness of scaffolds to the cellular scale and stacking or rolling the cell-scaffold complex into 3D constructs. We devise a series of novel tools to fabricate, characterize, and manipulate ultra-thin electrospun scaffolds, which demonstrate high reproducibility, resolution, and cellularity. Our study provides a solution to the cell infiltration issue in muscle tissue engineering and is highly versatile, and can be applied to various fields that require structures with high-resolution gradients in a layered pattern or complex spatial distribution in a rolled pattern.

In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.

This should be corrected to “Xing-Jie Liang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”

We apologize for this error.

In the “CONFLICT OF INTEREST STATEMENT” section, the text “The authors declare no conflicts of interest.” is incomplete.

This should be corrected to “Changyong Wang is an editorial board member of the BMEMat journal and was not involved in the editorial review or the decision to publish this article. All authors declare no competing interests.”

We apologize for the error.