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British Journal of Tuberculosis and Diseases of the Chest最新文献

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Pneumoconiosis in grain workers, oil and flour millers 粮食工人、油和面粉加工工人的尘肺病
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80004-0
L. Dünner, R. Hardy, E. Nakielny, L.B. Robinson, G.A. Smart

Chest disease and morbidity has been studied among a group of 31 persons (grain workers, oil and flour millers, flour packer) exposed to inhaling mixed vegetable dusts at work. Pulmonary fibrotic lesions or simple pneumoconiosis were found histologically in 4 out of 5 cases in which post-mortem examination was done. Radiologically, various types of lung damage (reticulation, micro-nodulation, irregular fibrosis) were encountered, conforming with the histological findings in 4 out of the 5 cases in which we were able to obtain post-mortem examination. Emphysema associated with this and other types of occupational lung disease has been discussed, and 10 cases of tuberculosis and 2 of bronchogenic carcinoma have been noted. Only in six cases were chest appearances normal.

对在工作中吸入混合蔬菜粉尘的31人(粮食工人、油和面粉加工工人、面粉包装工人)的胸部疾病和发病率进行了研究。5例尸检患者中有4例在组织学上发现肺纤维化病变或单纯性尘肺病。影像学上,我们发现了各种类型的肺损伤(网状、微结节、不规则纤维化),这与我们能够获得尸检的5例病例中4例的组织学结果一致。肺气肿与这种和其他类型的职业性肺病有关,并已注意到10例肺结核和2例支气管源性肺癌。只有6例胸部表现正常。
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引用次数: 3
Effect of adequate long-term chemotherapy on relapse in pulmonary tuberculosis 适当的长期化疗对肺结核复发的影响
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80008-8
A.C. Ronald, J.F. Stitt

This paper is a review of patients with pulmonary tuberculosis at the Toronto Hospital, Weston, “adequately” treated and discharged by medical consent between January 1954 and June 1956. It is not an account of a study carefully planned in advance, but a retrospective report of results obtained by treatment then in vogue (namely long-term chemotherapy with at least two drugs, but usually three, for a period of one year, and surgical measures where these seemed to be indicated).

The total number of all patients discharged during this time was 1,734. Of these, 850 were considered suitable for review in that they satisfied our criteria of adequate treatment. Six hundred and forty-eight were actually traced and of these 20 have relapsed to date (June 1958); 5 more were re-admitted because of recurrence of symptoms of pulmonary disease, but reactivation could not be established; 6 patients died of causes other than tuberculosis. The relapse rate is thus 3·1 per cent.

The relapse cases were studied in detail. The ages ranged from 22 to 67 years and 10 of the 20 patients were aged 40 years or less at time of relapse. Eight were females and 12 were male patients.

Sensitivity to drugs was complete in 11, unreported in 3, and in 2 patients tubercle bacilli were not cultured. Partial resistance only to one drug was encountered in the remaining 4 patients. Only one of the 20 patients had a resection (lobectomy) performed, but 3 had thoracoplasty as part of their treatment before relapse. It is of interest that in 4 patients resection was considered necessary but was not done for various reasons.

This study seems to confirm tentative conclusions previously held by us regarding predisposition to relapse after treatment.

本文回顾了1954年1月至1956年6月期间在韦斯顿多伦多医院接受“充分”治疗并经医疗同意出院的肺结核患者。这并不是一项事先精心计划的研究,而是对当时流行的治疗方法(即至少两种药物的长期化疗,但通常是三种,为期一年,以及似乎需要这些药物的手术措施)所获得的结果的回顾性报告。在此期间出院的患者总数为1734人。其中,850个被认为是适合审查的,因为它们符合我们的适当治疗标准。实际追踪到的有648人,其中20人至今(1958年6月)复发;另有5例因肺部疾病症状复发而再次入院,但无法确定是否再次发病;6例患者死于结核病以外的原因。复发率为3.1%,对复发率进行了详细的研究。年龄从22岁到67岁不等,20例患者中有10例复发时年龄在40岁以下。女性8例,男性12例。11例对药物完全敏感,3例未报道,2例未培养结核杆菌。其余4例患者仅对一种药物部分耐药。20例患者中只有1例进行了肺叶切除术,但3例在复发前进行了胸廓成形术。有趣的是,有4例患者认为切除是必要的,但由于各种原因没有做。这项研究似乎证实了我们之前关于治疗后易复发的初步结论。
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引用次数: 1
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80015-5
Philip Ellman
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引用次数: 0
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80019-2
W.M. Levitt
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引用次数: 0
A fatal case of viomycin hypersensitivity 维霉素过敏致死症1例
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80010-6
R.G. Benians, C.J. Pinto

A case is recorded of renal damage, fever and drug rash following twice weekly viomycin treatment. At post-mortem the renal tubules showed necrosis.

报告1例患者在每周2次服用维霉素后出现肾损害、发热和药物性皮疹。死后肾小管出现坏死。
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引用次数: 0
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80017-9
R.W. Riddell
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引用次数: 1
Reports 报告
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80022-2
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引用次数: 0
Laryngeal palsy following spontaneous pneumothorax 自发性气胸后喉麻痹
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80011-8
H. Duff Palmer, S.K. Gupta

A case of laryngeal palsy following spontaneous pneumothorax is described. The possible mode of occurrence and the relevant literature is discussed.

报告一例自发性气胸后喉部麻痹。讨论了可能的发生方式和相关文献。
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引用次数: 2
Advances in the pharmacological study of cerase—A new anti-tuberculous agent 新型抗结核药物脂酶的药理研究进展
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80007-6
Mahmoud Kamal Muftic

Although several enzymes have previously been tried therapeutically, cerase is the first to show definite antibacterial effect. Low toxicity and highly specific antibacterial activity facilitate clinical research, and the apparent anti-tuberculous activity in both animal and human cases justifies larger scale clinical trials, which are in progress. Besides bibliographical data, this article contains information about the pharmacological properties of cerase, and preliminary observations on its use in the treatment of human tuberculosis.

虽然已有几种酶被用于治疗,但葡萄酶是第一个显示出明确的抗菌作用的酶。低毒性和高度特异性的抗菌活性促进了临床研究,并且在动物和人类病例中明显的抗结核活性证明了更大规模的临床试验正在进行中。除了参考文献数据,这篇文章包含了关于谷氨酸酶的药理学性质的信息,以及它在治疗人类结核病中的应用的初步观察。
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引用次数: 1
The value of scalene node biopsy in intrathoracic disease 斜角肌淋巴结活检在胸内病变中的价值
Pub Date : 1958-10-01 DOI: 10.1016/S0366-0869(58)80003-9
H.C. Nohl

The value of scalene node biopsy as a diagnostic procedure in intrathoracic disease is established beyond doubt. The percentage of positive biopsies depends on the thoroughness with which the operation is carried out and is especially high in cases of sarcoidosis. The results of the present study bear out the author's previously published views on the lymphatic drainage of the lungs and give a guide to the question of which side should be explored. Right-sided lesions always give rise to pathological changes on the right. In cases where no lymph nodes are palpable, the right supraclavicular region should be explored irrespective of whether the lesion in the chest is on the left or right. Similarly, in bilateral lesions a right scalene node biopsy is advised. Only when the left supraclavicular nodes are palpable should this side be operated upon. A bilateral exploration is only justifiable where a right scalene node biopsy is negative and the case cannot be diagnosed by any other means.

斜角肌淋巴结活检作为胸内疾病的诊断方法的价值是毋庸置疑的。活检阳性的百分比取决于手术的彻底性,在结节病的病例中尤其高。本研究的结果证实了作者以前发表的关于肺淋巴引流的观点,并对应该探索哪一边的问题提供了指导。右侧病变常引起右侧病变。在未触及淋巴结的情况下,无论胸部病变是在左侧还是右侧,都应检查右侧锁骨上区。同样,在双侧病变中,建议行右斜角淋巴结活检。只有当左侧锁骨上淋巴结可触及时,才能对这一侧进行手术。只有当右斜角淋巴结活检呈阴性且无法通过其他方法诊断时,双侧探查才是合理的。
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引用次数: 6
期刊
British Journal of Tuberculosis and Diseases of the Chest
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