首页 > 最新文献

Cancer Innovation最新文献

英文 中文
Current insights into the oncogenic roles of lncRNA LINC00355 目前对 lncRNA LINC00355 致癌作用的认识
Pub Date : 2023-09-14 DOI: 10.1002/cai2.91
Jinze Shen, Xinming Su, Ming Pan, Zehua Wang, Yufei Ke, Qurui Wang, Jingyin Dong, Shiwei Duan

Long noncoding RNAs (lncRNAs) are a class of nonprotein-coding transcripts that are longer than 200 nucleotides. LINC00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various cancers. It regulates the expression of downstream genes at both transcriptional and posttranscriptional levels, including eight microRNAs (miR-15a-5p, miR-34b-5p, miR-424-5p, miR-1225, miR-217-5p, miR-6777-3p, miR-195, and miR-466) and three protein-coding genes (ITGA2, RAD18, and UBE3C). LINC00355 plays a role in regulating various biological processes such as cell cycle progression, proliferation, apoptosis, epithelial-mesenchymal transition, invasion, and metastasis of cancer cells. It is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling pathway. Upregulation of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival, recurrence-free survival, and disease-free survival. LINC00355 upregulation has been linked to several unfavorable clinical characteristics, including advanced tumor node metastasis and World Health Organization stages, reduced Karnofsky Performance Scale scores, increased tumor size, greater depth of invasion, and more extensive lymph node metastasis. LINC00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes, namely HMGA2, ABCB1, ITGA2, WNT10B, and CCNE1 genes. In summary, LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer.

长非编码 RNA(lncRNA)是一类长度超过 200 个核苷酸的非蛋白编码转录本。LINC00355 是位于染色体 13q21.31 上的一种 lncRNA,在各种癌症中持续上调。它在转录和转录后水平调节下游基因的表达,包括 8 个 microRNA(miR-15a-5p、miR-34b-5p、miR-424-5p、miR-1225、miR-217-5p、miR-6777-3p、miR-195 和 miR-466)和 3 个蛋白编码基因(ITGA2、RAD18 和 UBE3C)。LINC00355 在调控癌细胞的细胞周期进展、增殖、凋亡、上皮-间质转化、侵袭和转移等多种生物学过程中发挥作用。它参与调控 Wnt/β-catenin 信号通路和 p53 信号通路。LINC00355 的上调已被确定为癌症患者的高危因素,其表达的增加与较差的总生存率、无复发生存率和无病生存率有关。LINC00355 的上调与几种不利的临床特征有关,包括晚期肿瘤结节转移和世界卫生组织分期、卡诺夫斯基表现量表评分降低、肿瘤体积增大、侵袭深度增加以及淋巴结转移范围扩大。LINC00355 通过调控五个下游基因,即 HMGA2、ABCB1、ITGA2、WNT10B 和 CCNE1 基因,诱导癌细胞产生化疗耐药性。总之,LINC00355 是一种潜在的癌基因,具有作为癌症诊断标志物和治疗靶点的巨大潜力。
{"title":"Current insights into the oncogenic roles of lncRNA LINC00355","authors":"Jinze Shen,&nbsp;Xinming Su,&nbsp;Ming Pan,&nbsp;Zehua Wang,&nbsp;Yufei Ke,&nbsp;Qurui Wang,&nbsp;Jingyin Dong,&nbsp;Shiwei Duan","doi":"10.1002/cai2.91","DOIUrl":"10.1002/cai2.91","url":null,"abstract":"<p>Long noncoding RNAs (lncRNAs) are a class of nonprotein-coding transcripts that are longer than 200 nucleotides. LINC00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various cancers. It regulates the expression of downstream genes at both transcriptional and posttranscriptional levels, including eight microRNAs (miR-15a-5p, miR-34b-5p, miR-424-5p, miR-1225, miR-217-5p, miR-6777-3p, miR-195, and miR-466) and three protein-coding genes (<i>ITGA2</i>, <i>RAD18</i>, and <i>UBE3C</i>). LINC00355 plays a role in regulating various biological processes such as cell cycle progression, proliferation, apoptosis, epithelial-mesenchymal transition, invasion, and metastasis of cancer cells. It is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling pathway. Upregulation of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival, recurrence-free survival, and disease-free survival. LINC00355 upregulation has been linked to several unfavorable clinical characteristics, including advanced tumor node metastasis and World Health Organization stages, reduced Karnofsky Performance Scale scores, increased tumor size, greater depth of invasion, and more extensive lymph node metastasis. LINC00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes, namely <i>HMGA2</i>, <i>ABCB1</i>, <i>ITGA2</i>, <i>WNT10B</i>, and <i>CCNE1</i> genes. In summary, LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer.</p>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 6","pages":"448-462"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.91","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134911711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The road toward breast cancer single-disease quality control in China 中国乳腺癌症单病质量控制之路
Pub Date : 2023-09-01 DOI: 10.1002/cai2.93
Bo Lan, Qiao Li, Fei Ma, Binghe Xu

Malignant tumors have become a major threat to human health worldwide. According to incomplete statistics from the World Health Organization, in 112 of 183 countries, malignant tumors are the primary cause of death among people under the age of 70, and cancer morbidity and mortality are increasing year by year [1]. Owing to the limits of current medical technology, it is impossible to completely overcome this persistent disease.

In China, with the development of the social economy and the advancement of medicine, the diagnosis and treatment of malignant tumors has improved year by year, along with the cure rate of early cancer patients, and the survival period of advanced cancer patients. Statistics from the National Cancer Center of China (NCC) show that the 5-year survival rate of malignant tumors in China has increased from 30.9% in 2003–2005 to 40.5% in 2012–2015 [2]. China clearly stated in the 2016 Outline of the Healthy China 2030 Plan that the health management of chronic diseases for the entire population and the whole life cycle will be realized by 2030, and the overall 5-year survival rate of cancer will increase by 15%. The 2019 State Council's Opinions on Implementing the Healthy China Action clarified this goal and proposed that by 2022 and 2030, the overall 5-year cancer survival rate should not be lower than 43.3% and 46.6%, respectively. In general, however, problems persist in China, such as uneven diagnosis and treatment levels, inadequate implementation of guidelines, and insufficient sharing of diagnosis and treatment information in the process of cancer diagnosis and treatment. Continuously improving the quality of cancer diagnosis and treatment and standardizing tumor diagnosis and treatment behavior are crucial to improving the cancer survival rate in China.

From the perspective of tumor diagnosis and treatment management, quality control is an important means to achieve the 5-year survival rate goal. Medical quality control refers to the process of establishing procedures and methods to examine and standardize the reliability and quality of all factors involved in medical work. Medical quality control is important for the guarantee of medical treatment. In recent years, the National Health Commission of the People's Republic of China (NHC) has insisted on carrying out single-disease treatment quality control in all medical institutions. The NHC issued the Notice on Further Strengthening the Quality Management and Control of Single Diseases in 2020 and the 2021 National Medical Quality and Safety Improvement Targets in February 2021, both of which included quality control indexes for standardized diagnosis and treatment of malignant tumors.

Breast cancer is currently the most common malignant tumor in the world. In 2020, there were 2.26 million new cases of breast cancer worldwide accounting for approximately 11.7% of new cancer cases [1

恶性肿瘤已成为世界范围内对人类健康的主要威胁。据世界卫生组织不完全统计,183个国家中有112个国家的70岁以下人群的主要死因是恶性肿瘤,癌症发病率和死亡率逐年上升[1]。由于目前医疗技术的限制,不可能完全克服这种顽疾。在中国,随着社会经济的发展和医学的进步,恶性肿瘤的诊断和治疗逐年提高,早期癌症患者的治愈率和晚期癌症患者的生存期也逐年提高。中国国家癌症中心(NCC)的统计数据显示,中国恶性肿瘤的5年生存率已从2003-2005年的30.9%上升到2012-2015年的40.5%[2]。中国在2016年《健康中国2030规划纲要》中明确提出,到2030年实现全人群、全生命周期慢性病健康管理,癌症总体5年生存率提高15%。2019年国务院《关于实施健康中国行动的意见》明确了这一目标,提出到2022年和2030年,癌症总体5年生存率分别不低于43.3%和46.6%。但总体而言,我国癌症诊疗过程中存在诊疗水平参差不齐、指导方针落实不到位、诊疗信息共享不足等问题。不断提高癌症诊疗质量,规范肿瘤诊疗行为,是提高我国癌症生存率的关键。从肿瘤诊断和治疗管理的角度来看,质量控制是实现5年生存率目标的重要手段。医疗质量控制是指建立程序和方法,以检查和规范医疗工作中所有因素的可靠性和质量的过程。医疗质量控制是保证医疗质量的重要环节。近年来,国家卫生健康委员会坚持在所有医疗机构开展单病治疗质量控制。国家卫生健康委员会于2021年2月发布了《关于进一步加强2020年单病种质量管控的通知》和《2021年国家医疗质量安全改进目标》,其中均包括恶性肿瘤规范诊疗质量控制指标。癌症是目前世界上最常见的恶性肿瘤。2020年,全球癌症新增病例226万例,约占癌症新增病例的11.7%[1]。在中国,癌症在女性恶性肿瘤中排名第一。2020年癌症新增病例41.6万例,死亡11.7万例[3]。癌症已成为危害我国妇女健康的突出疾病。尽管我国乳腺癌症诊疗水平不断提高,但不同地区医疗机构在乳腺癌症诊疗中仍存在诊疗水平参差不齐、同质化差等问题。因此,提高我国癌症患者的整体生存率,离不开各级医疗机构加强癌症乳腺规范化诊疗,而规范化诊疗又有赖于医疗质量控制管理的发展。为进一步加强国家乳腺癌症单病诊疗质量控制管理,2018年8月3日,国家癌症中心与国家癌症质量控制中心成立了第一个单病质量控制专家委员会:国家癌症质量控制中心乳腺癌症专家委员会。其成员包括外科、医学肿瘤学、放射治疗、影像学、病理学、癌症诊治药学等领域的50多位知名专家学者。自成立以来,该委员会一直致力于加强对癌症医疗质量的管控,规范各级医疗机构癌症乳腺诊疗活动,提高全国癌症乳腺诊疗水平。 该专家委员会成立后,制定了一些国家指导方针和规范(涵盖癌症诊疗全过程,包括国家卫生健康委员会《癌症乳腺诊疗指南》、《癌症乳腺合理用药指南》、中国《癌症筛查与早诊早治标准》、《中国晚期乳腺癌症规范化诊疗指南》和《随访指南》癌症健康管理),癌症质量控制管理的顶层框架基本完整。在此基础上,从2019年开始,专家委员会聚焦制度建设,推动质量控制管理具体措施落地。在组织体系建设方面,专家委员会重点开展了三项工作:(1)成立省级癌症单病质量控制专家委员会;(2) 建立癌症单病质量控制亚专科组;(3)癌症标准化诊疗质量控制试点项目建设。在NCC的帮助下,这三项任务自上而下地进行,并在全国范围内得到了积极回应。到目前为止,已有20多个省份成立了癌症单病质量控制省级专家委员会。通过国家癌症单病质量控制体系,专门委员会建立并推进了放射诊断、超声诊断、病理诊断、内科治疗、外科治疗、放射治疗、药物管理等7个子专业质量控制体系的建设。2019年9月,NCC创建了癌症标准化诊疗质量控制试点项目,旨在加强单肿瘤疾病诊疗的标准化管理,建立和完善国家癌症标准化诊疗和质量控制体系,提高全国癌症诊治水平。在短时间内,近1000家医院提交了该试点项目的申请。在选择试点中心时,专家委员会从多个角度对申请人进行了审查,包括学科程度、学术影响力、医疗条件和相关监测数据。2020年12月,根据公平、公正、科学、合理的原则和相关筛选条件,国家癌症中心和国家癌症质量控制中心癌症乳腺癌专家委员会筛选了200家医院作为试点中心。这些质量控制试点单位覆盖了除西藏以外的全国30个省(区、市)。特委会目前正在评估首批乳腺癌症标准化诊疗试点项目,将把国家癌症质量控制中心乳腺癌症标准化诊疗质量控制标准中心/示范中心授予建设期质量控制合格的试点单位。第二批试点单位的申请也已开始。没有准确的数据,质量控制就无法开始。为贯彻落实国家质量控制信息化工作要求,国家疾控中心坚持“一源多用、平台共享”的原则,利用国家抗肿瘤药物临床应用监测网建立了癌症乳腺特殊疾病数据库。该数据库包括19种类型的数据表、25种表格和1509个字段,包括患者门诊、住院、药物、医疗技术、治疗和随访的信息。此外,质量控制中心要求癌症质量控制试点单位在国家抗癌药物临床应用监测网络的监测范围内,通过自动对接向监测平台报告数据。经过监测网络和试点单位的共同努力,截至2023年7月31日,首批200家试点单位全部成为国家抗肿瘤药物临床应用监测网络的监测单位,数十家单位已开始通过自动对接向监测网络上报数据。
{"title":"The road toward breast cancer single-disease quality control in China","authors":"Bo Lan,&nbsp;Qiao Li,&nbsp;Fei Ma,&nbsp;Binghe Xu","doi":"10.1002/cai2.93","DOIUrl":"https://doi.org/10.1002/cai2.93","url":null,"abstract":"<p>Malignant tumors have become a major threat to human health worldwide. According to incomplete statistics from the World Health Organization, in 112 of 183 countries, malignant tumors are the primary cause of death among people under the age of 70, and cancer morbidity and mortality are increasing year by year [<span>1</span>]. Owing to the limits of current medical technology, it is impossible to completely overcome this persistent disease.</p><p>In China, with the development of the social economy and the advancement of medicine, the diagnosis and treatment of malignant tumors has improved year by year, along with the cure rate of early cancer patients, and the survival period of advanced cancer patients. Statistics from the National Cancer Center of China (NCC) show that the 5-year survival rate of malignant tumors in China has increased from 30.9% in 2003–2005 to 40.5% in 2012–2015 [<span>2</span>]. China clearly stated in the 2016 <i>Outline of the Healthy China 2030 Plan</i> that the health management of chronic diseases for the entire population and the whole life cycle will be realized by 2030, and the overall 5-year survival rate of cancer will increase by 15%. The 2019 <i>State Council's Opinions on Implementing the Healthy China Action</i> clarified this goal and proposed that by 2022 and 2030, the overall 5-year cancer survival rate should not be lower than 43.3% and 46.6%, respectively. In general, however, problems persist in China, such as uneven diagnosis and treatment levels, inadequate implementation of guidelines, and insufficient sharing of diagnosis and treatment information in the process of cancer diagnosis and treatment. Continuously improving the quality of cancer diagnosis and treatment and standardizing tumor diagnosis and treatment behavior are crucial to improving the cancer survival rate in China.</p><p>From the perspective of tumor diagnosis and treatment management, quality control is an important means to achieve the 5-year survival rate goal. Medical quality control refers to the process of establishing procedures and methods to examine and standardize the reliability and quality of all factors involved in medical work. Medical quality control is important for the guarantee of medical treatment. In recent years, the National Health Commission of the People's Republic of China (NHC) has insisted on carrying out single-disease treatment quality control in all medical institutions. The NHC issued the <i>Notice on Further Strengthening the Quality Management and Control of Single Diseases</i> in 2020 and the <i>2021 National Medical Quality and Safety Improvement Targets</i> in February 2021, both of which included quality control indexes for standardized diagnosis and treatment of malignant tumors.</p><p>Breast cancer is currently the most common malignant tumor in the world. In 2020, there were 2.26 million new cases of breast cancer worldwide accounting for approximately 11.7% of new cancer cases [<span>1</span","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 5","pages":"319-322"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71921168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a nomogram to predict cardiac death after radiotherapy for esophageal cancer 预测食管癌症放疗后心脏死亡的列线图的开发和验证
Pub Date : 2023-09-01 DOI: 10.1002/cai2.89
Xinfang Lv, Xue Wu, Kai Liu, Xinke Zhao, Chenliang Pan, Jing Zhao, Juan Chang, Huan Guo, Xiang Gao, Xiaodong Zhi, Chunzhen Ren, Qilin Chen, Hugang Jiang, Chunling Wang, Ying-Dong Li

Background

Patients frequently die from cardiac causes after radiotherapy for esophageal cancer. Early detection of cardiac death risk in these patients is crucial to improve clinical decision-making and prognosis. Thus, we modeled the risk of cardiac death after irradiation for esophageal cancer.

Methods

A retrospective analysis of 37,599 esophageal cancer cases treated with radiotherapy in the SEER database between 2000 and 2018 was performed. The selected cases were randomly assigned to the model development group (n = 26,320) and model validation group (n = 11,279) at a ratio of 7:3. We identified the risk factors most commonly associated with cardiac death by least absolute shrinkage and selection operator regression analysis (LASSO). The endpoints for model development and validation were 5- and 10-year survival rates. The net clinical benefit of the models was evaluated by decision curve analysis (DCA) and concordance index (C-index). The performance of the models was further assessed by creating a receiver operating characteristic curve (ROC) and calculating the area under the curve (AUC). Kaplan-Meier (K-M) survival analysis was performed on the probability of death. Patients were classified according to death probability thresholds. Five- and ten-year survival rates for the two groups were shown using K-M curves.

Results

The major risk factors for cardiac death were age, surgery, year of diagnosis, sequence of surgery and radiotherapy, chemotherapy and a number of tumors, which were used to create the nomogram. The C-indexes of the nomograms were 0.708 and 0.679 for the development and validation groups, respectively. DCA showed the good net clinical benefit of nomograms in predicting 5- and 10-year risk of cardiac death. The model exhibited moderate predictive power for 5- and 10-year cardiac mortality (AUC: 0.833 and 0.854, respectively), and for the development and validation cohorts (AUC: 0.76 and 0.813, respectively).

Conclusions

Our nomogram may assist clinicians in making clinical decisions about patients undergoing radiotherapy for esophageal cancer based on early detection of cardiac death risk.

背景癌症食管癌放疗后,患者常死于心脏原因。早期发现这些患者的心脏死亡风险对于改善临床决策和预后至关重要。因此,我们对食管癌症放射治疗后心脏死亡的风险进行了建模。方法回顾性分析2000年至2018年SEER数据库中37599例癌症放疗病例。所选病例被随机分配到模型开发组(n = 26320)和模型验证组(n = 11279),比例为7:3。我们通过最小绝对收缩和选择算子回归分析(LASSO)确定了最常见的与心脏死亡相关的风险因素。模型开发和验证的终点是5年和10年生存率。通过决策曲线分析(DCA)和一致性指数(C指数)评估模型的净临床效益。通过创建受试者工作特性曲线(ROC)并计算曲线下面积(AUC)来进一步评估模型的性能。对死亡概率进行Kaplan-Meier(K-M)生存分析。根据死亡概率阈值对患者进行分类。使用K-M曲线显示两组患者的5年和10年生存率。结果心脏性死亡的主要危险因素是年龄、手术、诊断年份、手术和放疗的顺序、化疗和一些肿瘤,这些因素用于创建列线图。开发组和验证组的列线图C指数分别为0.708和0.679。DCA显示列线图在预测5年和10年心脏死亡风险方面具有良好的净临床效益。该模型对5年和10年心脏死亡率(AUC:0.833和0.854)以及开发和验证队列(AUC=0.76和0.813)表现出中等的预测能力。结论我们的列线图可以帮助临床医生在早期检测心脏死亡风险的基础上,对癌症食管放疗患者做出临床决策。
{"title":"Development and validation of a nomogram to predict cardiac death after radiotherapy for esophageal cancer","authors":"Xinfang Lv,&nbsp;Xue Wu,&nbsp;Kai Liu,&nbsp;Xinke Zhao,&nbsp;Chenliang Pan,&nbsp;Jing Zhao,&nbsp;Juan Chang,&nbsp;Huan Guo,&nbsp;Xiang Gao,&nbsp;Xiaodong Zhi,&nbsp;Chunzhen Ren,&nbsp;Qilin Chen,&nbsp;Hugang Jiang,&nbsp;Chunling Wang,&nbsp;Ying-Dong Li","doi":"10.1002/cai2.89","DOIUrl":"https://doi.org/10.1002/cai2.89","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients frequently die from cardiac causes after radiotherapy for esophageal cancer. Early detection of cardiac death risk in these patients is crucial to improve clinical decision-making and prognosis. Thus, we modeled the risk of cardiac death after irradiation for esophageal cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis of 37,599 esophageal cancer cases treated with radiotherapy in the SEER database between 2000 and 2018 was performed. The selected cases were randomly assigned to the model development group (<i>n</i> = 26,320) and model validation group (<i>n</i> = 11,279) at a ratio of 7:3. We identified the risk factors most commonly associated with cardiac death by least absolute shrinkage and selection operator regression analysis (LASSO). The endpoints for model development and validation were 5- and 10-year survival rates. The net clinical benefit of the models was evaluated by decision curve analysis (DCA) and concordance index (C-index). The performance of the models was further assessed by creating a receiver operating characteristic curve (ROC) and calculating the area under the curve (AUC). Kaplan-Meier (K-M) survival analysis was performed on the probability of death. Patients were classified according to death probability thresholds. Five- and ten-year survival rates for the two groups were shown using K-M curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The major risk factors for cardiac death were age, surgery, year of diagnosis, sequence of surgery and radiotherapy, chemotherapy and a number of tumors, which were used to create the nomogram. The C-indexes of the nomograms were 0.708 and 0.679 for the development and validation groups, respectively. DCA showed the good net clinical benefit of nomograms in predicting 5- and 10-year risk of cardiac death. The model exhibited moderate predictive power for 5- and 10-year cardiac mortality (AUC: 0.833 and 0.854, respectively), and for the development and validation cohorts (AUC: 0.76 and 0.813, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our nomogram may assist clinicians in making clinical decisions about patients undergoing radiotherapy for esophageal cancer based on early detection of cardiac death risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 5","pages":"391-404"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71921167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics of malignant germ cell tumors in adolescents: A multicenter 10-year retrospective study in Beijing 青少年恶性生殖细胞瘤的临床特征:北京一项多中心 10 年回顾性研究
Pub Date : 2023-08-20 DOI: 10.1002/cai2.87
Qian Zhao, Miao Li, Qing Sun, Tian Zhi, Mei Jin, Wen Zhao, Xisi Wang, Chao Duan, Xiaoli Ma, Wanshui Wu, Weihong Zhao, Dongsheng Huang, Yan Su

Background

The aim of this study was to review clinical features of adolescent malignant germ cell tumors (MGCTs) in Beijing and analyze the peculiar characteristics of this age group.

Methods

Clinical characteristics, pathological presentations, and survival outcomes of 34 patients were analyzed retrospectively.

Results

Of 34 patients, 12 girls and 22 boys, 18 (52.9%) had an extra-cranial tumor, including one testicular tumor, five ovarian tumors, one sacrococcygeal tumor, and 11 mediastinal tumors. Histologically, we found immature teratomas (n = 6), yolk sac tumors (n = 5), mixed malignant tumors (n = 5), an embryonic carcinoma (n = 1), and seminoma (n = 1). Three-year event-free survival (EFS) and overall survival (OS) were 48.8% and 62.9%, respectively. Another 16 (47.1%) patients had an intracranial tumor, including nine in the pineal region, five in the suprasellar region, one in basal ganglia, and one in cerebellopontine. All patients had localized disease and an excellent outcome with 3-year EFS and OS of 93.7% and 100%, respectively.

Conclusions

Adolescent MGCTs are rare with a strong dependence on gender, and the mediastina and pineal region are the most common tumor locations. The prognosis is promising compared with that of other adolescent tumors and MGCTs in other age groups. MGCTs in mediastina have a tendency to companion with other hematological malignancies, and the prognosis is extremely poor in these patients.

背景 本研究旨在回顾北京地区青少年恶性生殖细胞瘤(MGCTs)的临床特征,并分析该年龄组的特殊性。 方法 回顾性分析 34 例患者的临床特征、病理表现和生存结果。 结果 34 例患者中,女孩 12 例,男孩 22 例,颅外肿瘤 18 例(52.9%),其中睾丸肿瘤 1 例,卵巢肿瘤 5 例,骶尾部肿瘤 1 例,纵隔肿瘤 11 例。在组织学上,我们发现了未成熟畸胎瘤(6 例)、卵黄囊肿瘤(5 例)、混合恶性肿瘤(5 例)、胚胎癌(1 例)和精原细胞瘤(1 例)。三年无事件生存率(EFS)和总生存率(OS)分别为48.8%和62.9%。另有16例(47.1%)患者患有颅内肿瘤,其中9例位于松果体区,5例位于小脑上区,1例位于基底节,1例位于小脑。所有患者均有局部病变,疗效极佳,3 年 EFS 和 OS 分别为 93.7% 和 100%。 结论 青少年多发性神经胶质瘤非常罕见,与性别有很大关系,纵隔和松果体区是最常见的肿瘤部位。与其他青少年肿瘤和其他年龄组的间变性肿瘤相比,其预后良好。纵隔内的间变性肿瘤有与其他血液恶性肿瘤伴发的倾向,这些患者的预后极差。
{"title":"Clinical characteristics of malignant germ cell tumors in adolescents: A multicenter 10-year retrospective study in Beijing","authors":"Qian Zhao,&nbsp;Miao Li,&nbsp;Qing Sun,&nbsp;Tian Zhi,&nbsp;Mei Jin,&nbsp;Wen Zhao,&nbsp;Xisi Wang,&nbsp;Chao Duan,&nbsp;Xiaoli Ma,&nbsp;Wanshui Wu,&nbsp;Weihong Zhao,&nbsp;Dongsheng Huang,&nbsp;Yan Su","doi":"10.1002/cai2.87","DOIUrl":"10.1002/cai2.87","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to review clinical features of adolescent malignant germ cell tumors (MGCTs) in Beijing and analyze the peculiar characteristics of this age group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical characteristics, pathological presentations, and survival outcomes of 34 patients were analyzed retrospectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 34 patients, 12 girls and 22 boys, 18 (52.9%) had an extra-cranial tumor, including one testicular tumor, five ovarian tumors, one sacrococcygeal tumor, and 11 mediastinal tumors. Histologically, we found immature teratomas (<i>n</i> = 6), yolk sac tumors (<i>n</i> = 5), mixed malignant tumors (<i>n</i> = 5), an embryonic carcinoma (<i>n</i> = 1), and seminoma (<i>n</i> = 1). Three-year event-free survival (EFS) and overall survival (OS) were 48.8% and 62.9%, respectively. Another 16 (47.1%) patients had an intracranial tumor, including nine in the pineal region, five in the suprasellar region, one in basal ganglia, and one in cerebellopontine. All patients had localized disease and an excellent outcome with 3-year EFS and OS of 93.7% and 100%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Adolescent MGCTs are rare with a strong dependence on gender, and the mediastina and pineal region are the most common tumor locations. The prognosis is promising compared with that of other adolescent tumors and MGCTs in other age groups. MGCTs in mediastina have a tendency to companion with other hematological malignancies, and the prognosis is extremely poor in these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 6","pages":"524-531"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.87","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82444886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expression and function of long noncoding RNAs in hepatocellular carcinoma 长非编码 RNA 在肝细胞癌中的表达和功能
Pub Date : 2023-08-15 DOI: 10.1002/cai2.90
Jingli Du, Yue Su, Jianzhi Gao, Yanhong Tai

With the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways. Aberrant expressions of lncRNAs have been found in a variety of human tumors including hepatocellular carcinoma (HCC). In this review, we provide a brief introduction to lncRNA and highlight recent research on the functions and clinical significance of lncRNAs in HCC.

随着基因组计划研究的深入,非编码 RNA 越来越受到关注。长非编码 RNA(lncRNA)已成为一个新的研究热点。越来越多的研究发现,lncRNAs 参与了肿瘤发生和肿瘤抑制通路。在包括肝细胞癌(HCC)在内的多种人类肿瘤中都发现了lncRNAs的异常表达。在这篇综述中,我们简要介绍了lncRNA,并重点介绍了最近关于lncRNA在HCC中的功能和临床意义的研究。
{"title":"The expression and function of long noncoding RNAs in hepatocellular carcinoma","authors":"Jingli Du,&nbsp;Yue Su,&nbsp;Jianzhi Gao,&nbsp;Yanhong Tai","doi":"10.1002/cai2.90","DOIUrl":"10.1002/cai2.90","url":null,"abstract":"<p>With the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways. Aberrant expressions of lncRNAs have been found in a variety of human tumors including hepatocellular carcinoma (HCC). In this review, we provide a brief introduction to lncRNA and highlight recent research on the functions and clinical significance of lncRNAs in HCC.</p>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 6","pages":"488-499"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.90","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73087975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial refinement of data from video-based single-cell tracking 基于视频的单细胞跟踪数据的初步细化
Pub Date : 2023-08-09 DOI: 10.1002/cai2.88
Mónica Suárez Korsnes, Reinert Korsnes

Background

Video recording of cells offers a straightforward way to gain valuable information from their response to treatments. An indispensable step in obtaining such information involves tracking individual cells from the recorded data. A subsequent step is reducing such data to represent essential biological information. This can help to compare various single-cell tracking data yielding a novel source of information. The vast array of potential data sources highlights the significance of methodologies prioritizing simplicity, robustness, transparency, affordability, sensor independence, and freedom from reliance on specific software or online services.

Methods

The provided data presents single-cell tracking of clonal (A549) cells as they grow in two-dimensional (2D) monolayers over 94 hours, spanning several cell cycles. The cells are exposed to three different concentrations of yessotoxin (YTX). The data treatments showcase the parametrization of population growth curves, as well as other statistical descriptions. These include the temporal development of cell speed in family trees with and without cell death, correlations between sister cells, single-cell average displacements, and the study of clustering tendencies.

Results

Various statistics obtained from single-cell tracking reveal patterns suitable for data compression and parametrization. These statistics encompass essential aspects such as cell division, movements, and mutual information between sister cells.

Conclusion

This work presents practical examples that highlight the abundant potential information within large sets of single-cell tracking data. Data reduction is crucial in the process of acquiring such information which can be relevant for phenotypic drug discovery and therapeutics, extending beyond standardized procedures. Conducting meaningful big data analysis typically necessitates a substantial amount of data, which can stem from standalone case studies as an initial foundation.

背景细胞的视频记录提供了一种直接的方法,可以从细胞对治疗的反应中获得有价值的信息。获得这种信息的一个不可或缺的步骤涉及从记录的数据中跟踪单个细胞。接下来的步骤是减少这样的数据以表示基本的生物信息。这可以帮助比较各种单小区跟踪数据,从而产生新的信息源。大量潜在的数据来源突出了方法论的重要性,这些方法论优先考虑简单性、稳健性、透明度、可负担性、传感器独立性以及不依赖特定软件或在线服务。方法所提供的数据显示了克隆(A549)细胞在二维(2D)单层中生长94小时,跨越几个细胞周期的单细胞跟踪。细胞暴露于三种不同浓度的叶索毒素(YTX)。数据处理展示了人口增长曲线的参数化,以及其他统计描述。其中包括有和没有细胞死亡的家谱中细胞速度的时间发展、姐妹细胞之间的相关性、单细胞平均位移以及聚类趋势的研究。结果从单细胞跟踪中获得的各种统计数据揭示了适合于数据压缩和参数化的模式。这些统计数据包括细胞分裂、运动和姐妹细胞之间的相互信息等重要方面。结论这项工作提供了一些实际的例子,突出了大量单细胞跟踪数据中丰富的潜在信息。数据减少在获取这些信息的过程中至关重要,这些信息可能与表型药物发现和治疗相关,超出了标准化程序。进行有意义的大数据分析通常需要大量的数据,这些数据可以来自作为初始基础的独立案例研究。
{"title":"Initial refinement of data from video-based single-cell tracking","authors":"Mónica Suárez Korsnes,&nbsp;Reinert Korsnes","doi":"10.1002/cai2.88","DOIUrl":"https://doi.org/10.1002/cai2.88","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Video recording of cells offers a straightforward way to gain valuable information from their response to treatments. An indispensable step in obtaining such information involves tracking individual cells from the recorded data. A subsequent step is reducing such data to represent essential biological information. This can help to compare various single-cell tracking data yielding a novel source of information. The vast array of potential data sources highlights the significance of methodologies prioritizing simplicity, robustness, transparency, affordability, sensor independence, and freedom from reliance on specific software or online services.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The provided data presents single-cell tracking of clonal (A549) cells as they grow in two-dimensional (2D) monolayers over 94 hours, spanning several cell cycles. The cells are exposed to three different concentrations of yessotoxin (YTX). The data treatments showcase the parametrization of population growth curves, as well as other statistical descriptions. These include the temporal development of cell speed in family trees with and without cell death, correlations between sister cells, single-cell average displacements, and the study of clustering tendencies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Various statistics obtained from single-cell tracking reveal patterns suitable for data compression and parametrization. These statistics encompass essential aspects such as cell division, movements, and mutual information between sister cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This work presents practical examples that highlight the abundant potential information within large sets of single-cell tracking data. Data reduction is crucial in the process of acquiring such information which can be relevant for phenotypic drug discovery and therapeutics, extending beyond standardized procedures. Conducting meaningful big data analysis typically necessitates a substantial amount of data, which can stem from standalone case studies as an initial foundation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 5","pages":"416-432"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71947646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global trends of cancer: The role of diet, lifestyle, and environmental factors 癌症的全球趋势:饮食、生活方式和环境因素的作用
Pub Date : 2023-07-25 DOI: 10.1002/cai2.76
Hassan Bahrami, Majid Tafrihi

Effective treatment of cancer requires understanding the nature of the disease and accurately addressing the main root causes. General risk factors for cancer include poor nutrition, an acidogenic diet, an unhealthy lifestyle, and exposure to carcinogens such as toxins, chemicals, and radiation. The risk of developing cancers may be reduced by sufficient oxygenation and maintaining optimal alkalinity and nutritional balance at the cell level. The review paper summarizes some diet and lifestyle modifications that may potentially be considered for preventing and controlling some cancers. Moreover, worldwide statistical data for cancer incidence rates published by International Agency for Research on Cancer are analyzed for certain cancers regionally, concerning the effect of dietary habits and environmental factors that meaningfully correlate with the global trends of cancer. The study of cancer root causes integrated with analyzing the statistics related to cancer incidence rates suggests that the risk of developing cancer may be reduced by modifying dietary habits and lifestyle factors, as well as reducing exposure to carcinogens. Those with healthy balanced dietary habits may have a lower cancer risk than those who frequently have unhealthy diets; hence, considering a balanced natural diet and healthy lifestyle may be suggested as a complementary or alternative solution in cancer treatments.

癌症的有效治疗需要了解疾病的性质并准确地解决主要根源。癌症的一般风险因素包括营养不良、嗜酸饮食、不健康的生活方式以及接触毒素、化学物质和辐射等致癌物。通过充分的氧合和在细胞水平上保持最佳的碱度和营养平衡,可以降低患癌症的风险。这篇综述文章总结了一些可能被考虑用于预防和控制某些癌症的饮食和生活方式的改变。此外,国际癌症研究机构公布的癌症发病率全球统计数据针对某些癌症进行了区域分析,涉及与癌症全球趋势有意义关联的饮食习惯和环境因素的影响。对癌症根源的研究结合了对癌症发病率相关统计数据的分析表明,通过改变饮食习惯和生活方式因素以及减少接触致癌物,可以降低患癌症的风险。那些有健康均衡饮食习惯的人可能比那些经常有不健康饮食的人患癌症的风险更低;因此,考虑均衡的自然饮食和健康的生活方式可以作为癌症治疗的补充或替代方案。
{"title":"Global trends of cancer: The role of diet, lifestyle, and environmental factors","authors":"Hassan Bahrami,&nbsp;Majid Tafrihi","doi":"10.1002/cai2.76","DOIUrl":"https://doi.org/10.1002/cai2.76","url":null,"abstract":"<p>Effective treatment of cancer requires understanding the nature of the disease and accurately addressing the main root causes. General risk factors for cancer include poor nutrition, an acidogenic diet, an unhealthy lifestyle, and exposure to carcinogens such as toxins, chemicals, and radiation. The risk of developing cancers may be reduced by sufficient oxygenation and maintaining optimal alkalinity and nutritional balance at the cell level. The review paper summarizes some diet and lifestyle modifications that may potentially be considered for preventing and controlling some cancers. Moreover, worldwide statistical data for cancer incidence rates published by International Agency for Research on Cancer are analyzed for certain cancers regionally, concerning the effect of dietary habits and environmental factors that meaningfully correlate with the global trends of cancer. The study of cancer root causes integrated with analyzing the statistics related to cancer incidence rates suggests that the risk of developing cancer may be reduced by modifying dietary habits and lifestyle factors, as well as reducing exposure to carcinogens. Those with healthy balanced dietary habits may have a lower cancer risk than those who frequently have unhealthy diets; hence, considering a balanced natural diet and healthy lifestyle may be suggested as a complementary or alternative solution in cancer treatments.</p>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 4","pages":"290-301"},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.76","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50143515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hepatoblastoma with neonatal necrotizing enterocolitis: Two case reports 伴有新生儿坏死性小肠结肠炎的肝母细胞瘤:两例报告
Pub Date : 2023-07-24 DOI: 10.1002/cai2.86
Sidou He, Xisi Wang, Chao Duan, Wen Zhao, Chiyi Jiang, Shihan Zhang, Binglin Jian, Wei Yang, Tong Yu, Libing Fu, Huanmin Wang, Xiaoli Ma

We report two children with hepatoblastoma (HB) with a history of neonatal necrotizing enterocolitis (NEC). Case 1 was diagnosed with HB at 5 months of age. Liver enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by imaging. After six chemotherapy courses, a partial hepatectomy was performed. Three months after ceasing the chemotherapy, a chest computed tomography scan suggested that distant metastasis of the tumor should be considered, and the lesion was removed. However, 9 months after the operation, alpha-fetoprotein concentrations were increased, and abdominal imaging showed a recurrence of the tumor in situ, resulting in a hepatectomy. Case 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month later. He was diagnosed with HB at 3 years of age. Hepatectomy was performed after five courses of chemotherapy. Chemotherapy was stopped after 10 courses, and alpha-fetoprotein concentrations were normal. At present, both children have survived and are in a healthy condition. Physicians should be aware of the possibility of HB and a history of NEC in children. Premature birth and low birth weight are common factors leading to the pathogenesis of HB and NEC. The association between these two diseases requires further study.

我们报告了两名患有肝母细胞瘤(HB)并有新生儿坏死性小肠结肠炎(NEC)病史的患儿。病例 1 在 5 个月大时被诊断为肝母细胞瘤。3 个月大时在 NEC 手术中发现肝脏肿大,随后通过影像学检查临床确诊。经过六个疗程的化疗后,进行了部分肝切除术。停止化疗三个月后,胸部计算机断层扫描提示应考虑肿瘤远处转移,于是切除了病灶。然而,手术 9 个月后,甲胎蛋白浓度升高,腹部造影显示肿瘤原位复发,因此进行了肝切除术。病例 2 出生后不久被诊断为 NEC,1 个月后接受了肠切除和吻合术。他在 3 岁时被诊断出患有 HB。化疗五个疗程后进行了肝切除术。化疗 10 个疗程后停止,甲胎蛋白浓度正常。目前,两个孩子都存活了下来,身体健康。医生应注意儿童患 HB 和 NEC 病史的可能性。早产和低出生体重是导致 HB 和 NEC 发病的常见因素。这两种疾病之间的关联需要进一步研究。
{"title":"Hepatoblastoma with neonatal necrotizing enterocolitis: Two case reports","authors":"Sidou He,&nbsp;Xisi Wang,&nbsp;Chao Duan,&nbsp;Wen Zhao,&nbsp;Chiyi Jiang,&nbsp;Shihan Zhang,&nbsp;Binglin Jian,&nbsp;Wei Yang,&nbsp;Tong Yu,&nbsp;Libing Fu,&nbsp;Huanmin Wang,&nbsp;Xiaoli Ma","doi":"10.1002/cai2.86","DOIUrl":"10.1002/cai2.86","url":null,"abstract":"<p>We report two children with hepatoblastoma (HB) with a history of neonatal necrotizing enterocolitis (NEC). Case 1 was diagnosed with HB at 5 months of age. Liver enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by imaging. After six chemotherapy courses, a partial hepatectomy was performed. Three months after ceasing the chemotherapy, a chest computed tomography scan suggested that distant metastasis of the tumor should be considered, and the lesion was removed. However, 9 months after the operation, alpha-fetoprotein concentrations were increased, and abdominal imaging showed a recurrence of the tumor in situ, resulting in a hepatectomy. Case 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month later. He was diagnosed with HB at 3 years of age. Hepatectomy was performed after five courses of chemotherapy. Chemotherapy was stopped after 10 courses, and alpha-fetoprotein concentrations were normal. At present, both children have survived and are in a healthy condition. Physicians should be aware of the possibility of HB and a history of NEC in children. Premature birth and low birth weight are common factors leading to the pathogenesis of HB and NEC. The association between these two diseases requires further study.</p>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 6","pages":"532-536"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.86","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81379538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in research on ultrasound radiomics for predicting the prognosis of breast cancer 超声放射组学预测癌症预后的研究进展
Pub Date : 2023-07-11 DOI: 10.1002/cai2.85
Xuantong Gong, Xuefeng Liu, Xiaozheng Xie, Yong Wang

Breast cancer is the most common malignant tumor and the leading cause of cancer-related deaths in women worldwide. Effective means of predicting the prognosis of breast cancer are very helpful in guiding treatment and improving patients' survival. Features extracted by radiomics reflect the genetic and molecular characteristics of a tumor and are related to its biological behavior and the patient's prognosis. Thus, radiomics provides a new approach to noninvasive assessment of breast cancer prognosis. Ultrasound is one of the commonest clinical means of examining breast cancer. In recent years, some results of research into ultrasound radiomics for diagnosing breast cancer, predicting lymph node status, treatment response, recurrence and survival times, and other aspects, have been published. In this article, we review the current research status and technical challenges of ultrasound radiomics for predicting breast cancer prognosis. We aim to provide a reference for radiomics researchers, promote the development of ultrasound radiomics, and advance its clinical application.

癌症是最常见的恶性肿瘤,也是全球女性癌症相关死亡的主要原因。预测癌症预后的有效手段对指导治疗和提高患者生存率有重要意义。放射组学提取的特征反映了肿瘤的遗传和分子特征,并与其生物学行为和患者预后有关。因此,放射组学为乳腺癌症预后的无创评估提供了一种新的方法。超声检查是癌症最常见的临床检查手段之一。近年来,超声放射组学在诊断癌症、预测淋巴结状态、治疗反应、复发和存活时间等方面的一些研究成果已经发表。本文综述了超声放射组学在预测癌症预后方面的研究现状和技术挑战。旨在为放射组学研究人员提供参考,促进超声放射组学的发展,促进其临床应用。
{"title":"Progress in research on ultrasound radiomics for predicting the prognosis of breast cancer","authors":"Xuantong Gong,&nbsp;Xuefeng Liu,&nbsp;Xiaozheng Xie,&nbsp;Yong Wang","doi":"10.1002/cai2.85","DOIUrl":"https://doi.org/10.1002/cai2.85","url":null,"abstract":"<p>Breast cancer is the most common malignant tumor and the leading cause of cancer-related deaths in women worldwide. Effective means of predicting the prognosis of breast cancer are very helpful in guiding treatment and improving patients' survival. Features extracted by radiomics reflect the genetic and molecular characteristics of a tumor and are related to its biological behavior and the patient's prognosis. Thus, radiomics provides a new approach to noninvasive assessment of breast cancer prognosis. Ultrasound is one of the commonest clinical means of examining breast cancer. In recent years, some results of research into ultrasound radiomics for diagnosing breast cancer, predicting lymph node status, treatment response, recurrence and survival times, and other aspects, have been published. In this article, we review the current research status and technical challenges of ultrasound radiomics for predicting breast cancer prognosis. We aim to provide a reference for radiomics researchers, promote the development of ultrasound radiomics, and advance its clinical application.</p>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 4","pages":"283-289"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.85","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50149437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small-cell lung cancer and enhance the efficacy of platinum-based chemotherapy DNA聚合酶结合途径的突变会影响小细胞肺癌患者的免疫微环境,并增强铂类化疗的疗效
Pub Date : 2023-07-11 DOI: 10.1002/cai2.84
Anqi Lin, Weiming Mou, Lingxuan Zhu, Tao Yang, Chaozheng Zhou, Jian Zhang, Peng Luo

Background

Small-cell lung cancer (SCLC) is characterized by its high malignancy and is associated with a poor prognosis. In the early stages of the disease, platinum-based chemotherapy is the recommended first-line treatment and has demonstrated efficacy. However, SCLC is prone to recurrence and is generally resistant to chemotherapy in its later stages.

Methods

Here, we collected samples from SCLC patients who received platinum-based chemotherapy, performed genomic and transcriptomic analyses, and validated our results with publicly available data.

Results

SCLC patients with DNA polymerase binding pathway mutations had an improved prognosis after platinum chemotherapy compared with patients without such mutations. Patients in the mutant (MT) group had higher infiltration of T cells, B cells, and M1 macrophages compared with patients without DNA polymerase binding pathway mutations.

Conclusions

DNA polymerase binding pathway mutations can be used as prognostic markers for platinum-based chemotherapy in SCLC.

背景 小细胞肺癌(SCLC)的特点是恶性程度高,预后较差。在疾病的早期阶段,以铂类为基础的化疗是推荐的一线治疗方法,且疗效显著。然而,SCLC 易复发,且晚期患者普遍对化疗耐药。 方法 我们收集了接受铂类化疗的 SCLC 患者样本,进行了基因组和转录组分析,并将结果与公开数据进行了验证。 结果 与未发生 DNA 聚合酶结合途径突变的患者相比,发生 DNA 聚合酶结合途径突变的 SCLC 患者接受铂类化疗后的预后有所改善。与未发生DNA聚合酶结合途径突变的患者相比,突变(MT)组患者的T细胞、B细胞和M1巨噬细胞浸润程度更高。 结论 DNA聚合酶结合途径突变可作为SCLC铂类化疗的预后标志。
{"title":"Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small-cell lung cancer and enhance the efficacy of platinum-based chemotherapy","authors":"Anqi Lin,&nbsp;Weiming Mou,&nbsp;Lingxuan Zhu,&nbsp;Tao Yang,&nbsp;Chaozheng Zhou,&nbsp;Jian Zhang,&nbsp;Peng Luo","doi":"10.1002/cai2.84","DOIUrl":"10.1002/cai2.84","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Small-cell lung cancer (SCLC) is characterized by its high malignancy and is associated with a poor prognosis. In the early stages of the disease, platinum-based chemotherapy is the recommended first-line treatment and has demonstrated efficacy. However, SCLC is prone to recurrence and is generally resistant to chemotherapy in its later stages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Here, we collected samples from SCLC patients who received platinum-based chemotherapy, performed genomic and transcriptomic analyses, and validated our results with publicly available data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SCLC patients with DNA polymerase binding pathway mutations had an improved prognosis after platinum chemotherapy compared with patients without such mutations. Patients in the mutant (MT) group had higher infiltration of T cells, B cells, and M1 macrophages compared with patients without DNA polymerase binding pathway mutations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DNA polymerase binding pathway mutations can be used as prognostic markers for platinum-based chemotherapy in SCLC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 6","pages":"500-512"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.84","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86647984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Cancer Innovation
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1