Dermatological Reviews最新文献_第7页

What's New in Diode Laser Hair Removal? 二极管激光脱毛的新进展？

Dermatological Reviews

Pub Date : 2024-09-10 DOI: 10.1002/der2.253

Rahul Pillai, Jisha Pillai

Introduction

Laser hair removal remains one of the most common procedures in cosmetic dermatology. It has always been challenging because of the higher competing epidermal melanocyte as the targeted hair chromophore is also melanin. As a result, to avoid unwanted side effects from laser therapy while maintaining high efficacy levels, the use of the right laser device, appropriate settings, and customized pre and posttreatment care are crucial. With more efficient versions of existing lasers in the market, the safety profile has been taken care of without compromising the efficacy. Diode lasers along with long pulsed Nd:YAG and alexandrite are considered as the safest hair removal lasers.

Objective

To summarize recent developments in diode laser hair reduction focusing on improvements in efficiency, safety, and patient compliance with recent innovations.

Materials and Methods

A review of recent literature updates in diode laser hair reduction technology focusing on multiwavelength systems, safety profiles, and innovations in laser device was searched using keywords diode laser hair removal and mutliwavelength diode laser devices.

Results

Currently, 810 nm diode laser is the most extensively used technology for the long term elimination of unwanted hair, thus establishing itself as an efficacious and safe modality. The rapid multiple pass in motion technique with lesser fluence and gradual heating of the skin epidermis was more well tolerated in patients than the higher fluence single shot method. Most popular combination of triple wavelength was 755, 810, and 1064 nm, which is considered most effective with least complications.

Conclusion

Diode lasers still remain the gold standard in laser hair removal especially on darker skin types. Recent innovations in diode laser have significantly improved the efficacy, safety, and patient compliance with hair reduction. Multiwavelength platforms seems to be the way forward, however the basic principles and certain problems like minimal pain, treating thin hair, paradoxical hair growth, white hair removal still remains a challenge.

导言激光脱毛仍然是美容皮肤科最常见的手术之一。由于目标毛发的发色团也是黑色素，表皮黑色素细胞的竞争性较强，因此激光脱毛一直是一项具有挑战性的工作。因此，为了避免激光治疗产生不必要的副作用，同时保持较高的疗效水平，使用正确的激光设备、适当的设置以及定制的治疗前后护理至关重要。随着市场上现有激光器的效率不断提高，在保证疗效的同时，安全性也得到了保障。二极管激光、长脉冲 Nd:YAG 和紫翠宝石被认为是最安全的脱毛激光。目的总结二极管激光脱毛的最新进展，重点关注最新创新技术在效率、安全性和患者依从性方面的改进。材料和方法以二极管激光脱毛和多波长二极管激光设备为关键词，对近期二极管激光脱毛技术的最新文献进行了回顾，重点关注多波长系统、安全性和激光设备的创新。结果目前，810 nm 二极管激光是最广泛使用的长期去除多余毛发的技术，从而确立了其作为一种有效而安全的方法的地位。与高通量的单次照射法相比，患者更容易接受以较低能量和逐渐加热皮肤表皮的快速多次照射技术。最受欢迎的三波长组合是 755、810 和 1064 纳米，这被认为是最有效且并发症最少的方法。结论二极管激光器仍然是激光脱毛的黄金标准，尤其适用于深色皮肤。二极管激光器的最新创新大大提高了脱毛的有效性、安全性和患者的依从性。多波长平台似乎是未来的发展方向，但基本原理和某些问题，如疼痛最小化、治疗稀疏毛发、矛盾性毛发生长、白毛脱除等，仍然是一个挑战。

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引用次数: 0

PRP, Exosomes, and Stem Cells: An International Perspective PRP、外泌体和干细胞：国际视角

Dermatological Reviews

Pub Date : 2024-09-06 DOI: 10.1002/der2.70000

Nupur Singh, Angela N. Brown, Michael H. Gold

Background

Regenerative medicine is a novel, developing field centered on efforts to repurpose the body's own molecular makeup to target specific problems. Specifically, the use of stem cells, platelet-rich plasma, and exosomes is rapidly expanding. Internationally, there remain different guidelines and a variety of medical uses, encouraging an exploration into the medical and cosmetic benefits offered.

Aims

This study aims to investigate current literature on the international perspectives of PRP, stem cells, and exosomes to present a global review on how these are obtained and utilized.

Methods

A literature search was conducted on PubMed reviewing PRP, exosomes, and stem cells, among other related topics, and their applications in medical, pharmacologic, and dermatologic fields. Research produced by various global regions was examined to identify similarities and differences.

Results

Stem cells have been successfully implemented in the oncology and dermatology realms as a result of their plasticity and ability to quickly replicate and divide. Platelet-rich plasma is of strong interest due to platelets' extracellular vesicles and their unmatched abilities. Exosomes are actively being studied in the fields of neurology and rheumatology, among others. International guidelines are reviewed based on regulations of these materials. Potential ethical barriers of isolation and source utilization are explored.

Conclusions

The perspectives and findings considered here stress the potential expanding uses of PRP, stem cells, and exosomes on a global scale. We highlight the need for further clinical studies and international collaboration among varying guidelines to best utilize these tools in the field of dermatology and medicine.

背景再生医学是一个不断发展的新领域，其核心是重新利用人体自身的分子构成来解决特定问题。具体来说，干细胞、富血小板血浆和外泌体的使用正在迅速扩大。国际上仍有不同的指导原则和多种医疗用途，这促使人们探索干细胞在医疗和美容方面的益处。目的本研究旨在调查目前有关 PRP、干细胞和外泌体的国际观点的文献，对这些物质的获取和使用方式进行全球综述。方法在 PubMed 上对 PRP、外泌体和干细胞等相关主题及其在医学、药学和皮肤病学领域的应用进行文献检索。对全球不同地区的研究进行了考察，以确定其异同。结果干细胞因其可塑性和快速复制和分裂的能力，已成功应用于肿瘤学和皮肤学领域。由于血小板的细胞外囊泡及其无与伦比的能力，富血小板血浆备受关注。神经学和风湿病学等领域正在积极研究外泌体。根据对这些材料的规定，对国际准则进行了审查。探讨了分离和利用外泌体的潜在伦理障碍。结论本文的观点和研究结果强调了PRP、干细胞和外泌体在全球范围内不断扩大用途的潜力。我们强调需要进一步开展临床研究，并在不同指南之间开展国际合作，以便在皮肤病学和医学领域更好地利用这些工具。

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引用次数: 0

Idiosyncratic Reaction of Isotretinoin: A Review 异维A酸的过敏反应：综述

Dermatological Reviews

Pub Date : 2024-09-06 DOI: 10.1002/der2.70001

Kar Wai Alvin Lee, Lisa Kwin Wah Chan, Cheuk Hung Lee, Jovian Wan, Kyu-Ho Yi

Background

Isotretinoin is widely recognized for its efficacy in treating severe acne. However, its use is associated with a variety of idiosyncratic reactions that can affect multiple organ systems and bodily functions, necessitating vigilant monitoring and appropriate management.

Objectives

The aim of this review is to raise awareness of the broad spectrum of adverse effects linked to isotretinoin therapy, thereby enhancing the ability of healthcare providers to identify at-risk individuals and improve patient outcomes.

Methods

A comprehensive review of current literature was conducted to explore the range of idiosyncratic reactions associated with isotretinoin. The focus was on identifying the types of adverse effects reported and the necessary monitoring strategies to mitigate these risks.

Results

Isotretinoin has been linked to a wide array of adverse effects, including, but not limited to, psychiatric issues (e.g., depression and suicidal behavior), hematological complications (e.g., neutropenia and agranulocytosis), gastrointestinal disturbances, cardiovascular effects, dermatological manifestations, hepatobiliary issues, ophthalmological changes, and orthopedic concerns. These reactions highlight the importance of careful patient monitoring during isotretinoin therapy.

Conclusion

Healthcare professionals prescribing isotretinoin must be aware of the potential for diverse idiosyncratic reactions and should implement appropriate monitoring protocols to ensure patient safety. By understanding and anticipating these adverse effects, healthcare providers can better manage the risks associated with isotretinoin use, ultimately improving the quality of care for patients undergoing treatment for severe acne.

背景异维A酸治疗严重痤疮的疗效已得到广泛认可。然而，使用异维A酸会产生多种特异性反应，可影响多个器官系统和身体功能，因此需要警惕监测和适当处理。目的本综述旨在提高人们对与异维A酸治疗相关的各种不良反应的认识，从而增强医疗服务提供者识别高危人群和改善患者预后的能力。方法对目前的文献进行了全面回顾，以探讨与异维A酸相关的一系列特异性反应。重点是确定报告的不良反应类型以及降低这些风险所需的监测策略。结果异维A酸与多种不良反应有关，包括但不限于精神问题（如抑郁和自杀行为）、血液并发症（如中性粒细胞减少症和粒细胞减少症）、胃肠道紊乱、心血管影响、皮肤病表现、肝胆问题、眼科变化和骨科问题。这些反应凸显了在异维A酸治疗期间对患者进行仔细监测的重要性。结论开具异维A酸处方的医护人员必须了解可能出现的各种特异性反应，并应实施适当的监测方案，以确保患者安全。通过了解和预测这些不良反应，医护人员可以更好地控制与异维A酸使用相关的风险，最终提高接受严重痤疮治疗的患者的护理质量。

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引用次数: 0

Advantages and Disadvantages of Using AI in Dermatology 在皮肤病学中使用人工智能的利弊

Dermatological Reviews

Pub Date : 2024-08-26 DOI: 10.1002/der2.248

Nasim Gholizadeh, Ghasem Rahmatpour Rokni, Mahsa Babaei

Introduction

Artificial intelligence (AI) in dermatology is both promising and challenging. This is important for clinicians to recognize most up-to-date knowledge and advancements.

Results

Advantages include timely detection and diagnosis, enhanced accuracy, efficient triage, workflow automation, personalized treatment, outcome prediction, education support, telemedicine aid, research facilitation, cost-efficiency, scalability, and drug development. However, limitations include generalizability issues, image quality variations, data requirements, interpretability concerns, patient acceptance, liability, multidisciplinary coordination challenges, data bias risks, lack of explainability, potential loss of clinical skills, security and privacy risks, resource intensiveness, integration challenges, validation and regulation gaps, and limited clinical assessment. Bridging these gaps requires robust ethical frameworks, interdisciplinary collaboration, education, regulation focusing on patient safety and privacy, standardized data sets, transparency, and human oversight.

Conclusion

Despite the challenges, AI holds significant potential to revolutionize dermatology practice, improving patient outcomes, healthcare accessibility, and research advancements. Further research and interdisciplinary collaboration are crucial to maximize AI's benefits and address its limitations effectively.

导言人工智能（AI）在皮肤病学中的应用既充满希望，又充满挑战。这对临床医生了解最新知识和进展非常重要。成果优势包括及时发现和诊断、提高准确性、高效分流、工作流程自动化、个性化治疗、结果预测、教育支持、远程医疗辅助、研究促进、成本效益、可扩展性和药物开发。然而，其局限性包括普遍性问题、图像质量差异、数据要求、可解释性问题、患者接受度、责任、多学科协调挑战、数据偏差风险、缺乏可解释性、潜在的临床技能损失、安全和隐私风险、资源密集性、集成挑战、验证和监管差距以及有限的临床评估。缩小这些差距需要健全的伦理框架、跨学科合作、教育、注重患者安全和隐私的监管、标准化数据集、透明度和人工监督。结论尽管存在各种挑战，但人工智能在彻底改变皮肤病学实践、改善患者治疗效果、提高医疗服务可及性和促进研究进展方面具有巨大潜力。要最大限度地发挥人工智能的优势并有效解决其局限性，进一步的研究和跨学科合作至关重要。

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引用次数: 0

Intense Pulsed Light Hair Removal 强脉冲光脱毛

Dermatological Reviews

Pub Date : 2024-08-22 DOI: 10.1002/der2.252

Hector Leal-Silva, Sebastián Leal-Delgado

Background

The use of intense pulsed light (IPL) for hair removal has proven to be quite effective for conditions such as hypertrichosis and hirsutism, as well as other skin conditions related to the pilosebaceous unit. IPL was developed in the 1990s and uses a broad spectrum of light to penetrate the skin and reach the hair follicle, enabling treatment for various skin types and hair colors. This review covers the history, mechanism of action, effectiveness, patient selection, and clinical applications of IPL hair removal.

Methods

To conduct this review, a comprehensive literature search was conducted to identify relevant peer-reviewed articles in English discussing the clinical use or application-based outcomes of this technology specifically for hair removal. The search covered the period from January 1990 to May 2024.

Results

The review of 33 peer-reviewed articles shows that IPL has significantly advanced hair removal treatment since its inception. A popular choice in clinical practice due to its efficacy, safety, and versatility, IPL hair removal has been successfully used in patients with skin conditions like acne, folliculitis, rosacea, and hyperpigmentation, offering additional benefits compared to laser hair removal.

Conclusion

IPL hair removal is a safe and effective option for reducing unwanted hair and improving skin appearance. It can also treat multiple skin conditions simultaneously with a low risk of side effects. Additionally, it's less painful than laser hair removal, making it an attractive option for long-lasting hair removal, especially for patients with co-existing dermatological conditions.

背景使用强脉冲光（IPL）脱毛已被证明对多毛症、多毛症以及其他与皮脂腺单位有关的皮肤病相当有效。强脉冲光是 20 世纪 90 年代开发的，它使用宽光谱光穿透皮肤直达毛囊，可治疗各种皮肤类型和毛发颜色。本综述涵盖 IPL 脱毛的历史、作用机制、效果、患者选择和临床应用。方法为了撰写这篇综述，我们进行了一次全面的文献检索，以找出相关的同行评审英文文章，这些文章讨论了该技术在脱毛方面的临床应用或基于应用的结果。搜索时间跨度为 1990 年 1 月至 2024 年 5 月。结果对 33 篇同行评议文章的审查表明，IPL 自诞生以来已大大推动了脱毛治疗的发展。IPL 脱毛因其有效性、安全性和多功能性而在临床实践中广受欢迎，已成功用于痤疮、毛囊炎、红斑痤疮和色素沉着等皮肤病患者，与激光脱毛相比具有更多优势。结论 IPL 脱毛是减少多余毛发和改善皮肤外观的安全有效的选择。它还能同时治疗多种皮肤病，副作用风险低。此外，与激光脱毛相比，强脉冲光脱毛的痛苦更小，是一种具有吸引力的持久脱毛方法，尤其适合同时患有皮肤病的患者。

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引用次数: 0

Basic Science and Principles of Stem Cells, Platelet-Rich Plasma, and Exosomes 干细胞、富血小板血浆和外泌体的基础科学与原理

Dermatological Reviews

Pub Date : 2024-08-22 DOI: 10.1002/der2.258

Elliott Lyles, Carol Stegura, Luke Broughton, Alan Snyder, Todd Schlesinger

Background

Regenerative medicine seeks to harness the natural healing abilities of the body and has scope for use in the treatment of dermatologic conditions. Stem cell therapy, platelet-rich plasma (PRP), and exosomes are emerging as key components in regenerative medicine, particularly in skin rejuvenation and repair.

Objectives

The goal of this article is to review the basic science behind the function of stem cells, PRP, and exosomes in regenerative medicine.

Methods

A literature review was conducted using PubMed and Google Scholar, focusing on basic science literature regarding the structure, origin, mechanisms of action, and isolation of stem cells, PRP, and exosomes.

Results

The evaluation found that stem cells facilitate skin regeneration by modulating the inflammatory milieu. PRP was shown to have positive effects on repairing skin elasticity and improving scars through the release of growth factors. Exosomes were found to enhance fibroblast proliferation and collagen synthesis.

Conclusions

Stem cell therapy, PRP, and exosomes each show mechanisms that render them useful in regenerative medicine. Future research is needed to further elucidate their mechanisms of action, standardize their isolation procedures, and optimize their potential for clinical application.

背景再生医学旨在利用人体的自然愈合能力，可用于治疗皮肤病。干细胞疗法、富血小板血浆（PRP）和外泌体正在成为再生医学的关键组成部分，尤其是在皮肤年轻化和修复方面。本文旨在回顾干细胞、血小板丰富血浆和外泌体在再生医学中的功能背后的基础科学。方法使用 PubMed 和 Google Scholar 进行文献综述，重点是有关干细胞、PRP 和外泌体的结构、起源、作用机制和分离的基础科学文献。结果评估发现，干细胞通过调节炎症环境促进皮肤再生。PRP 通过释放生长因子，对修复皮肤弹性和改善疤痕有积极作用。外泌体可促进成纤维细胞增殖和胶原蛋白合成。结论干细胞疗法、PRP 和外泌体都显示出使它们在再生医学中发挥作用的机制。未来的研究需要进一步阐明它们的作用机制，规范它们的分离程序，并优化它们的临床应用潜力。

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引用次数: 0

Introduction to the Future of Regenerative Medicine: Unveiling Exosomes, PRP, and Stem Cells 介绍再生医学的未来：揭开外泌体、PRP 和干细胞的神秘面纱

Dermatological Reviews

Pub Date : 2024-08-16 DOI: 10.1002/der2.257

Jane Yoo

引用次数: 0

Oral Supplements and Dermatology: A Review 口服补充剂与皮肤病学：综述

Dermatological Reviews

Pub Date : 2024-08-16 DOI: 10.1002/der2.239

Rachel Reeves, Emily Lebowitz Luks

Introduction

There is growing interest in the utility of oral supplements for improving overall health and wellness. Dietary supplements and nutraceuticals with antioxidant and anti-inflammatory properties have gained particular attention for their potential to optimize skin health. This review summarizes evidence for the following vitamins, minerals, and natural compounds in the realm of dermatology: niacinamide, vitamin D, vitamin C, vitamin E, zinc, omega-3 fatty acids, probiotics, polyphenols, Polypodium leucotomos, coenzyme Q10, and astaxanthin.

Results

Niacinamide and vitamins C, D, and E may all protect against UV damage. Zinc and omega-3 fatty acids may be useful for the treatment of acne and for minimizing side effects from isotretinoin. There is convincing evidence for the utility of probiotics in complementing standard treatments for acne, psoriasis, and atopic dermatitis. Collagen supplements have demonstrated anti-aging effects but should not be routinely recommended due to their unreliable quality. Antioxidants such as P. leucotomos, coenzyme Q10, astaxanthin, and polyphenols may play a role in anti-aging and photoprotection.

Conclusion

Oral supplements may play a beneficial role in skin health, namely in terms of photoprotection, anti-aging, and inflammatory conditions such as atopic dermatitis, acne, and psoriasis. However, further high-quality studies are needed.

导言：人们越来越关注口服营养补充剂在改善整体健康和保健方面的作用。具有抗氧化和抗炎特性的膳食补充剂和保健食品因其优化皮肤健康的潜力而受到特别关注。本综述总结了以下维生素、矿物质和天然化合物在皮肤病学领域的应用证据：烟酰胺、维生素 D、维生素 C、维生素 E、锌、ω-3 脂肪酸、益生菌、多酚、白果多糖、辅酶 Q10 和虾青素。结果烟酰胺、维生素 C、D 和 E 都可以抵御紫外线的伤害。锌和欧米伽-3 脂肪酸可能有助于治疗痤疮和减少异维A酸的副作用。有令人信服的证据表明，益生菌可以辅助痤疮、牛皮癣和特应性皮炎的标准治疗。胶原蛋白补充剂具有抗衰老作用，但由于其质量不可靠，不应作为常规推荐。白头翁、辅酶 Q10、虾青素和多酚等抗氧化剂可能在抗衰老和光保护方面发挥作用。结论口服营养补充剂可能对皮肤健康有益，即在光保护、抗衰老以及特应性皮炎、痤疮和牛皮癣等炎症方面。不过，还需要进一步开展高质量的研究。

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引用次数: 0

Emerging Technologies in Hair and Nail Diagnosis and Treatment 头发和指甲诊断与治疗的新兴技术

Dermatological Reviews

Pub Date : 2024-08-13 DOI: 10.1002/der2.251

Piyali Banerjee, Kinnor Das, Mohamad Goldust, Carlos Gustavo Wambier

Background

Emerging technologies are revolutionizing dermatology, especially for diagnosing and treating hair and nail disorders. Latest advancements in technology enhance the ability to visualize cutaneous structures, enabling early and precise detection of dermatological pathologies. This review aims to highlight these novel technological advancements and their therapeutic implications.

Objective

The objective of this review is to discuss the emerging and latest diagnostic and therapeutic technologies in the field of hair and nail disorders, highlighting their potential to improve diagnostic accuracy, treatment outcomes, and overall patient care.

Methods

A comprehensive review of existing literature was conducted on emerging diagnostic techniques, including dermoscopy, reflectance confocal microscopy, optical coherence tomography, multispectral imaging, and trichogram. Therapeutic advancements such as low-level laser therapy, platelet-rich plasma therapy, photo dynamic therapy, gene therapy, nanoemulsion topical treatments, biomimetic peptides, stem cell therapy, transdermal drug delivery systems, liposomal delivery systems, and drug tattooing were analyzed. The role of the latest technology in the form of artificial was also explored.

Results

We found that these emerging technologies significantly enhance the visualization of hair and nail structures, allowing for enhanced diagnoses and targeted management. These techniques improve early detection of disorders, while emerging therapies are showing promising results in treating hair and nail and related pathologies. AI-driven technologies further personalize patient care by providing data-driven insights.

Conclusion

The integration of advanced diagnostic and therapeutic technologies in clinical practice is transforming the arena of dermatology, particularly in hair and nail care. These novel technologies provide improved diagnostic precision, effective management options, and tailored patient care, paving the way for a technologically driven, precision-based approach in dermatology.

背景新兴技术正在彻底改变皮肤病学，尤其是在诊断和治疗毛发和指甲疾病方面。最新技术的进步提高了可视化皮肤结构的能力，从而能够及早、精确地检测皮肤病。本综述旨在重点介绍这些新技术的进步及其治疗意义。目的本综述旨在讨论毛发和指甲疾病领域新兴的最新诊断和治疗技术，强调这些技术在提高诊断准确性、治疗效果和整体患者护理方面的潜力。方法对有关新兴诊断技术的现有文献进行了全面回顾，这些技术包括皮肤镜、反射共聚焦显微镜、光学相干断层扫描、多光谱成像和毛发图。此外，还分析了低强度激光疗法、富血小板血浆疗法、光动力疗法、基因疗法、纳米乳液外用疗法、仿生肽、干细胞疗法、透皮给药系统、脂质体给药系统和药物纹身等先进治疗方法。此外，还探讨了以人工形式出现的最新技术的作用。结果我们发现，这些新兴技术大大提高了头发和指甲结构的可视化程度，从而可以加强诊断和有针对性的管理。这些技术提高了疾病的早期检测能力，而新兴疗法在治疗头发和指甲及相关病症方面也显示出良好的效果。人工智能驱动的技术通过提供数据驱动的洞察力，进一步实现了患者护理的个性化。结论在临床实践中整合先进的诊断和治疗技术正在改变皮肤科领域，尤其是头发和指甲护理领域。这些新技术提高了诊断的精确度，提供了有效的治疗方案，为患者提供了量身定制的护理，为皮肤病学中以技术为驱动、以精确为基础的方法铺平了道路。

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引用次数: 0

Looking Beyond PRP, Exosomes, and Stem Cells 超越 PRP、外泌体和干细胞的视野

Dermatological Reviews

Pub Date : 2024-08-13 DOI: 10.1002/der2.254

Faraz Yousefian, Marianne Cortes, Sujitha Yadlapati, Michael Gold

Background

The history of stem cells in dermatology is marked by significant discoveries and advancements. Stem cells, which possess the ability to differentiate into various cell types and self-renew, have played crucial roles in maintaining tissue integrity and facilitating wound healing. PRP has additionally emerged as a potent therapeutic agent with widespread applications due to its regenerative properties driven by platelets, and various growth factors. The newest addition to the regenerative medicine toolbox has been exosomes and extracellular vesicles containing biomolecules, offering a minimally invasive approach through non-cell therapy. These vesicles impact crucial cellular functions such as proliferation, migration, and apoptosis.

Aim

We aim to provide a comprehensive review on the history and future implications of stem cells, PRP, and exosomes in the fields of regenerative medicine and dermatology. This paper highlights the importance of ongoing research and development in optimizing these therapies for clinical applications, ultimately aiming to improve patient outcomes and quality of life.

Methods

A literature search was conducted on PubMed reviewing stem cells, PRP, MeSH, and exosomes and their application in the field of dermatology.

Results

The use of stem cells, PRP, and exosomes suggests the great advancements that we have made in regenerative medicine. The tight regulation of stem cells and their byproducts has halted further application of these novel modalities and suggested a need for further research and studies. Although this has slowed down the process of using these powerful tools, we are still continuing to understand the functions and implications of stem cells and their byproducts. With a new emphasis on non-cell therapy through exosomes and PRP, we are still able to apply these methods to ameliorate chronic dermatological diseases such as chronic wounds, scarring, androgenetic alopecia (ANA), and aesthetics.

Conclusions

Although the field of regenerative medicine is looking promising with its various novel additions, there is still work that needs to be done such as regulatory hurdles, safety concerns, and the need for standardization of isolation, storage, dosage, and application.

背景干细胞在皮肤病学中的历史以重大发现和进步为标志。干细胞具有分化成各种细胞类型和自我更新的能力，在保持组织完整性和促进伤口愈合方面发挥着至关重要的作用。此外，血小板和各种生长因子的再生特性使 PRP 成为一种有效的治疗剂，并得到广泛应用。再生医学工具箱中最新增加了外泌体和含有生物分子的细胞外囊泡，通过非细胞疗法提供了一种微创方法。这些囊泡对增殖、迁移和凋亡等关键细胞功能产生影响。目的我们旨在全面回顾干细胞、PRP 和外泌体在再生医学和皮肤病学领域的历史和未来影响。本文强调了在临床应用中不断研究和开发优化这些疗法的重要性，最终目的是改善患者的治疗效果和生活质量。方法在PubMed上对干细胞、PRP、MeSH和外泌体及其在皮肤科领域的应用进行了文献检索。结果干细胞、PRP 和外泌体的使用表明我们在再生医学方面取得了巨大进步。对干细胞及其副产品的严格监管阻止了这些新模式的进一步应用，并表明需要进一步的研究和调查。虽然这延缓了使用这些强大工具的进程，但我们仍在继续了解干细胞及其副产品的功能和意义。随着外泌体和PRP成为非细胞疗法的新重点，我们仍然能够应用这些方法来改善慢性皮肤病，如慢性伤口、疤痕、雄激素性脱发（ANA）和美学。结论尽管再生医学领域前景广阔，有各种新颖的添加物，但仍有许多工作要做，如监管障碍、安全问题以及分离、储存、剂量和应用标准化的需要。

{"title":"Looking Beyond PRP, Exosomes, and Stem Cells","authors":"Faraz Yousefian, Marianne Cortes, Sujitha Yadlapati, Michael Gold","doi":"10.1002/der2.254","DOIUrl":"https://doi.org/10.1002/der2.254","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The history of stem cells in dermatology is marked by significant discoveries and advancements. Stem cells, which possess the ability to differentiate into various cell types and self-renew, have played crucial roles in maintaining tissue integrity and facilitating wound healing. PRP has additionally emerged as a potent therapeutic agent with widespread applications due to its regenerative properties driven by platelets, and various growth factors. The newest addition to the regenerative medicine toolbox has been exosomes and extracellular vesicles containing biomolecules, offering a minimally invasive approach through non-cell therapy. These vesicles impact crucial cellular functions such as proliferation, migration, and apoptosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aim to provide a comprehensive review on the history and future implications of stem cells, PRP, and exosomes in the fields of regenerative medicine and dermatology. This paper highlights the importance of ongoing research and development in optimizing these therapies for clinical applications, ultimately aiming to improve patient outcomes and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search was conducted on PubMed reviewing stem cells, PRP, MeSH, and exosomes and their application in the field of dermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The use of stem cells, PRP, and exosomes suggests the great advancements that we have made in regenerative medicine. The tight regulation of stem cells and their byproducts has halted further application of these novel modalities and suggested a need for further research and studies. Although this has slowed down the process of using these powerful tools, we are still continuing to understand the functions and implications of stem cells and their byproducts. With a new emphasis on non-cell therapy through exosomes and PRP, we are still able to apply these methods to ameliorate chronic dermatological diseases such as chronic wounds, scarring, androgenetic alopecia (ANA), and aesthetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the field of regenerative medicine is looking promising with its various novel additions, there is still work that needs to be done such as regulatory hurdles, safety concerns, and the need for standardization of isolation, storage, dosage, and application.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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