Nodulocystic acne is a severe form of acne characterized by inflamed nodules and cysts, often causing significant emotional distress and scarring. While oral corticosteroids are commonly used to treat nodulocystic acne, they can have systemic side effects. Intralesional corticosteroid injections offer a targeted and localized approach, reducing the risk of systemic side effects.
This literature review aims to evaluate the efficacy, safety, and tolerability of steroid injections for the treatment of nodulocystic acne.
A comprehensive search of electronic databases was conducted to identify relevant studies on the use of intralesional corticosteroids for nodulocystic acne. Studies were included if they reported on the use of intralesional corticosteroids as a primary treatment modality for nodulocystic acne.
The review included studies that reported on the use of intralesional corticosteroids for nodulocystic acne. The results suggest that steroid injections can be an effective treatment option, with significant reductions in lesion size and severity reported in several studies. The addition of lincomycin to intralesional corticosteroids was found to enhance therapeutic efficacy, while cold anesthesia was effective in reducing pain during injections. Proper technique and dosage are essential to minimize discomfort and reduce the risk of complications.
This review suggests that steroid injections can be a valuable treatment option for nodulocystic acne, offering targeted and localized delivery of corticosteroids with reduced risk of systemic side effects. Further research is needed to confirm these findings and establish optimal treatment regimens.
Aging is a global biological process characterized by degenerative changes in physiological systems, most notably a decrease in face muscle tone and soft tissue volume, which have a substantial impact on facial esthetics in the periorbital area. This systematic study assesses the clinical outcomes of different thread lifting procedures for brow rejuvenation, with an emphasis on safety, efficacy, and side effects.
To promote scientific rigor and transparency, this systematic review used the latest PRISMA-E guidelines (2020). A thorough literature search was carried out using numerous databases, including Google Scholar, PubMed/MEDLINE, Embase, PsycINFO, TRIP, and the Cochrane Library. The I2 value of 0.92 indicates significant variety in study designs, patient characteristics, and therapies.
A total of 6 studies were included, with 419 patients in sample sizes ranging from 12 to 193 (mean = 69). Participants had an average age of 55 years (range: 21–89) and were monitored for 10–11 months. All investigations used standardized photographic assessments (100%). Ecchymosis and post-procedural edema were the most common side effects observed, accounting for 83.4% of all cases. Notably, two-thirds of the studies (66.7%) demonstrated a low risk of bias, indicating moderate methodological robustness and internal validity.
Thread lifting procedures for brow rejuvenation have a positive safety and efficacy profile, providing a viable nonsurgical alternative to established approaches. Future research, particularly large-scale, long-term randomized controlled trials, is critical for refining these strategies and developing evidence-based clinical recommendations.
Hair removal is a fundamental aspect of daily life, with various hair removal methods evolving throughout hair removal history to meet cultural, aesthetic, and spiritual needs. Traditional hair removal practices have long sought effective hair removal products that not only remove hair but also promote skin health. Cyperus rotundus L. (Cr L.), known as nut grass or purple nut sedge, has long been used in traditional medicinal systems like Ayurveda and Traditional Chinese Medicine (TCM) for treating various ailments, including skin conditions and depilation.
To understand the role of Cr L. in decreasing hair growth.
Cr L. contains essential oils (EOs) and phytochemicals such as flavonoids, alkaloids, and saponins, which contribute to its hair-removal properties. These compounds target hair follicles, dissolve keratin, and inhibit hair regrowth by modulating biological pathways. γ-curcumene, a key component, has been shown to suppress hair growth. Recent clinical trials have demonstrated the efficacy of Cyperus rotundus EO (CREO) in reducing hair growth, with minimal side effects. CREO has been found as effective as Alexandrite laser treatments in some cases, particularly in reducing white hair. This positions Cr L. as a promising natural alternative to chemical depilatories, which often cause skin irritation.
Cr L. shows significant potential as a natural hair removal agent. With its strong safety profile and growing consumer demand for natural, sustainable beauty products, Cr L. could serve as a viable alternative to synthetic depilatories, pending further clinical validation.
Aquasomes are novel nanoparticulate carriers that are applied topically to deliver medications, particularly in dermatology. These carriers are composed of a polyhydroxy oligomer layer covering a solid core, usually composed of ceramic or calcium phosphate. The bioactivity of delicate molecules, such as proteins, peptides, and genetic material, is preserved by this special structure. Aquasomes are especially useful for improving the stability, bioavailability, and controlled release of therapeutic substance, while reducing systemic absorption and unfavorable side effects.
The efficacy of aquasomes in treating dermatological conditions has been the subject of recent research. Their capacity to administer anti-inflammatory medications for ailments like acne, psoriasis as well as wound healing has been investigated. Additionally, research has looked into how well aquasomes can help bigger molecules pass through the epidermal barrier. The effectiveness, safety, as well as skin irritation of aquasomes have been evaluated through comparisons with traditional topical formulations.
Aquasomes were less irritating and more effective than conventional topical applications for localized skin conditions. Furthermore, a 2024 study showed that aquasomes improved the ability of big molecules to pass through the epidermal barrier, which made them appropriate for noninvasive medication administration.
In the fields of dermatology and cosmetics, aquasomes hold great promise as a topical treatment delivery system. With fewer adverse effects, they provide improved stability, bioavailability, along with controlled drug release. The therapeutic value for dealing with skin conditions and enhancing cosmetic formulations will be maximized with continued research to optimize their properties.
Teledermatology, a branch of telemedicine, utilizes telecommunication technologies for remote dermatological care, covering diagnosis, treatment planning, and patient monitoring. This study presents a review of the latest advances in teledermatology.
Database searches were performed within PubMed, EMBase, and Google Scholar using the keywords “Artificial Intelligence,” “Teledermatology,” “Telemedicine,” and “Dermatology.” All relevant documents were screened and included in the study.
Teledermatology employs synchronous and asynchronous interactions alongside remote monitoring, breaking geographical barriers to access dermatologic expertise. Supported by digital imaging, secure communication platforms, and artificial intelligence, teledermatology aids in diagnosis, treatment, and follow-up. In education, teledermatology facilitates remote learning, case review, and interdisciplinary collaboration, providing access to diverse patient populations and mentorship opportunities. It also contributes to continuing medical education and telemedicine skill development. In research, teledermatology supports epidemiological studies, diagnostic accuracy assessments, clinical trials, and quality improvement initiatives. Despite its benefits, challenges like image quality, regulatory issues, and the digital divide persist.
The evolution of teledermatology depends on technological advancements, regulatory frameworks, and reimbursement models. By addressing challenges and embracing innovation, teledermatology promises to enhance dermatologic care, patient outcomes, and healthcare efficiency in the digital era.
Vitiligo is a chronic autoimmune dermatosis characterized by progressive hypopigmentation, which affects ~0.2%–2% of the global population. This condition can have significant psychosocial impacts, particularly in individuals with darker skin phenotypes. Recent studies have suggested that Janus kinase (JAK) inhibitors, especially topical ruxolitinib, could offer therapeutic potential in managing vitiligo.
To systematically review the therapeutic efficacy, safety profile, and potential synergistic effects of topical JAK inhibitors, particularly ruxolitinib, in the treatment of vitiligo.
A systematic review was conducted in accordance with the PRISMA guidelines. Data from 6 studies, encompassing 385 subjects, were synthesized. The primary outcome measure was the improvement in Vitiligo Area Scoring Index (VASI), and the methodological quality was assessed using the MINORS scale.
Topical ruxolitinib demonstrated a statistically significant improvement in VASI scores (pooled estimate = 0.58; 95% CI: 0.44–0.73; p ≤ 0.001). The synergistic effect of ruxolitinib combined with narrowband ultraviolet B (NB-UVB) phototherapy yielded a mean VASI score improvement of 37.6%. Furthermore, 30.4% of patients receiving 1.5% ruxolitinib cream achieved a 75% improvement in facial VASI (F-VASI) scores.
Topical JAK inhibitors, including ruxolitinib, show considerable efficacy in improving VASI scores and facilitating repigmentation in vitiligo patients. The combination of JAK inhibitors with NB-UVB therapy demonstrates enhanced therapeutic effects. These findings underscore the potential of JAK inhibitors as effective treatment modalities, although further research is needed to standardize treatment protocols and evaluate long-term impacts on patient quality of life.
Artificial intelligence (AI) is transforming dermatopathology by enhancing diagnostic accuracy, efficiency, and precision medicine. Despite its promise, challenges such as dataset biases, underrepresentation of diverse populations, and limited transparency hinder its widespread adoption. Addressing these gaps can set a new standard for equitable and patient-centered care. To evaluate how AI mitigates biases, improves interpretability, and promotes inclusivity in dermatopathology while highlighting novel technologies like multimodal models and explainable AI (XAI).
AI-driven tools demonstrate significant improvements in diagnostic precision, particularly through multimodal models that integrate histological, genetic, and clinical data. Inclusive frameworks, such as the Monk scale, and advanced segmentation methods effectively address dataset biases. However, challenges such as the “black box” nature of AI, ethical concerns about data privacy, and limited access to advanced technologies in low-resource settings remain.
AI offers transformative potential in dermatopathology, enabling equitable, and innovative diagnostics. Overcoming persistent challenges will require collaboration among dermatopathologists, AI developers, and policymakers. By prioritizing inclusivity, transparency, and interdisciplinary efforts, AI can redefine global standards in dermatopathology and foster patient-centered care.
The integration of artificial intelligence (AI) and machine learning (ML) has revolutionized aesthetic medicine, enhancing the diagnosis, classification, and treatment of skin conditions. These technologies offer high precision, personalized care, and the potential to reduce human error. This review aimed to evaluate the current applications of AI and ML in aesthetic medicine, focusing on studies graded as Level I or II evidence by the Oxford Centre for Evidence-Based Medicine (CEBM).
A comprehensive search of MEDLINE, PubMed, and Ovid databases identified studies employing AI and ML for diagnosing and managing skin conditions. Studies were included if they demonstrated high diagnostic accuracy, improved treatment personalization, or other measurable clinical outcomes.
AI and ML systems showed high accuracy in detecting and diagnosing conditions such as skin cancer, acne, psoriasis, and seborrheic dermatitis. AI-based platforms facilitated personalized treatment plans, enhancing therapeutic outcomes while minimizing errors. The integration of AI reduced diagnostic time and lowered healthcare costs, demonstrating significant potential for improving patient care. However, challenges such as algorithmic bias, data privacy concerns, and the need for high-quality training datasets were highlighted.
AI and ML have transformative potential in aesthetic medicine, offering improved diagnostic precision, enhanced patient outcomes, and cost reductions. Addressing limitations related to algorithm bias, regulatory oversight, and data quality is essential to fully realize the benefits of AI in clinical practice. Future research should focus on developing robust, ethical, and regulatory-compliant AI solutions.
Vitamin C is a well-known product used in cosmeceuticals for its various topical application benefits ranging from antioxidative, antiaging, anti-inflammatory, and anti-pigmentary among others. The main problems encountered with vitamin C products include the stability, penetrance into the skin, and tolerance of vitamin C's various forms.
This paper aims to explore current literature on the role of Vitamin C in cosmetic dermatology and present a review on how products have developed for certain purposes and their outcomes.
A literature search was conducted on PubMed reviewing vitamin C in cosmetic and non-cosmetic formulations and its utility for cosmetic dermatologic conditions. Research produced by various journals was then investigated to highlight its uses and potential in the field.
Numerous studies support the varied claims regarding topical vitamin C, particularly in its role as an antioxidant, antiaging, anti-pigmentary, and anti-inflammatory agent. The integration of Vitamin C with other cosmetic ingredients is rapidly developing, ranging from vitamin E and natural plant extracts to several exfoliative acids and growth factors. The cosmetic industry's next steps involve better stabilization to improve the synergistic mechanisms with other ingredients and without lowering its bioavailability, efficacy, or absorption.
Vitamin C has proven to be a powerful player in cosmetic dermatology, both as a stand-alone element and in combination with cosmetic ingredients. This review showcases some of the most pertinent clinical studies that support its efficacy in mitigating photoaging, oxidative stress, abnormal pigmentation, and inflammation among other cosmetic concerns, underscoring the promise behind vitamin C.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：