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Emerging Technologies in Hair and Nail Diagnosis and Treatment 头发和指甲诊断与治疗的新兴技术
Pub Date : 2024-08-13 DOI: 10.1002/der2.251
Piyali Banerjee, Kinnor Das, Mohamad Goldust, Carlos Gustavo Wambier

Background

Emerging technologies are revolutionizing dermatology, especially for diagnosing and treating hair and nail disorders. Latest advancements in technology enhance the ability to visualize cutaneous structures, enabling early and precise detection of dermatological pathologies. This review aims to highlight these novel technological advancements and their therapeutic implications.

Objective

The objective of this review is to discuss the emerging and latest diagnostic and therapeutic technologies in the field of hair and nail disorders, highlighting their potential to improve diagnostic accuracy, treatment outcomes, and overall patient care.

Methods

A comprehensive review of existing literature was conducted on emerging diagnostic techniques, including dermoscopy, reflectance confocal microscopy, optical coherence tomography, multispectral imaging, and trichogram. Therapeutic advancements such as low-level laser therapy, platelet-rich plasma therapy, photo dynamic therapy, gene therapy, nanoemulsion topical treatments, biomimetic peptides, stem cell therapy, transdermal drug delivery systems, liposomal delivery systems, and drug tattooing were analyzed. The role of the latest technology in the form of artificial was also explored.

Results

We found that these emerging technologies significantly enhance the visualization of hair and nail structures, allowing for enhanced diagnoses and targeted management. These techniques improve early detection of disorders, while emerging therapies are showing promising results in treating hair and nail and related pathologies. AI-driven technologies further personalize patient care by providing data-driven insights.

Conclusion

The integration of advanced diagnostic and therapeutic technologies in clinical practice is transforming the arena of dermatology, particularly in hair and nail care. These novel technologies provide improved diagnostic precision, effective management options, and tailored patient care, paving the way for a technologically driven, precision-based approach in dermatology.

背景 新兴技术正在彻底改变皮肤病学,尤其是在诊断和治疗毛发和指甲疾病方面。最新技术的进步提高了可视化皮肤结构的能力,从而能够及早、精确地检测皮肤病。本综述旨在重点介绍这些新技术的进步及其治疗意义。 目的 本综述旨在讨论毛发和指甲疾病领域新兴的最新诊断和治疗技术,强调这些技术在提高诊断准确性、治疗效果和整体患者护理方面的潜力。 方法 对有关新兴诊断技术的现有文献进行了全面回顾,这些技术包括皮肤镜、反射共聚焦显微镜、光学相干断层扫描、多光谱成像和毛发图。此外,还分析了低强度激光疗法、富血小板血浆疗法、光动力疗法、基因疗法、纳米乳液外用疗法、仿生肽、干细胞疗法、透皮给药系统、脂质体给药系统和药物纹身等先进治疗方法。此外,还探讨了以人工形式出现的最新技术的作用。 结果 我们发现,这些新兴技术大大提高了头发和指甲结构的可视化程度,从而可以加强诊断和有针对性的管理。这些技术提高了疾病的早期检测能力,而新兴疗法在治疗头发和指甲及相关病症方面也显示出良好的效果。人工智能驱动的技术通过提供数据驱动的洞察力,进一步实现了患者护理的个性化。 结论 在临床实践中整合先进的诊断和治疗技术正在改变皮肤科领域,尤其是头发和指甲护理领域。这些新技术提高了诊断的精确度,提供了有效的治疗方案,为患者提供了量身定制的护理,为皮肤病学中以技术为驱动、以精确为基础的方法铺平了道路。
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引用次数: 0
Looking Beyond PRP, Exosomes, and Stem Cells 超越 PRP、外泌体和干细胞的视野
Pub Date : 2024-08-13 DOI: 10.1002/der2.254
Faraz Yousefian, Marianne Cortes, Sujitha Yadlapati, Michael Gold

Background

The history of stem cells in dermatology is marked by significant discoveries and advancements. Stem cells, which possess the ability to differentiate into various cell types and self-renew, have played crucial roles in maintaining tissue integrity and facilitating wound healing. PRP has additionally emerged as a potent therapeutic agent with widespread applications due to its regenerative properties driven by platelets, and various growth factors. The newest addition to the regenerative medicine toolbox has been exosomes and extracellular vesicles containing biomolecules, offering a minimally invasive approach through non-cell therapy. These vesicles impact crucial cellular functions such as proliferation, migration, and apoptosis.

Aim

We aim to provide a comprehensive review on the history and future implications of stem cells, PRP, and exosomes in the fields of regenerative medicine and dermatology. This paper highlights the importance of ongoing research and development in optimizing these therapies for clinical applications, ultimately aiming to improve patient outcomes and quality of life.

Methods

A literature search was conducted on PubMed reviewing stem cells, PRP, MeSH, and exosomes and their application in the field of dermatology.

Results

The use of stem cells, PRP, and exosomes suggests the great advancements that we have made in regenerative medicine. The tight regulation of stem cells and their byproducts has halted further application of these novel modalities and suggested a need for further research and studies. Although this has slowed down the process of using these powerful tools, we are still continuing to understand the functions and implications of stem cells and their byproducts. With a new emphasis on non-cell therapy through exosomes and PRP, we are still able to apply these methods to ameliorate chronic dermatological diseases such as chronic wounds, scarring, androgenetic alopecia (ANA), and aesthetics.

Conclusions

Although the field of regenerative medicine is looking promising with its various novel additions, there is still work that needs to be done such as regulatory hurdles, safety concerns, and the need for standardization of isolation, storage, dosage, and application.

背景干细胞在皮肤病学中的历史以重大发现和进步为标志。干细胞具有分化成各种细胞类型和自我更新的能力,在保持组织完整性和促进伤口愈合方面发挥着至关重要的作用。此外,血小板和各种生长因子的再生特性使 PRP 成为一种有效的治疗剂,并得到广泛应用。再生医学工具箱中最新增加了外泌体和含有生物分子的细胞外囊泡,通过非细胞疗法提供了一种微创方法。这些囊泡对增殖、迁移和凋亡等关键细胞功能产生影响。 目的 我们旨在全面回顾干细胞、PRP 和外泌体在再生医学和皮肤病学领域的历史和未来影响。本文强调了在临床应用中不断研究和开发优化这些疗法的重要性,最终目的是改善患者的治疗效果和生活质量。 方法 在PubMed上对干细胞、PRP、MeSH和外泌体及其在皮肤科领域的应用进行了文献检索。 结果 干细胞、PRP 和外泌体的使用表明我们在再生医学方面取得了巨大进步。对干细胞及其副产品的严格监管阻止了这些新模式的进一步应用,并表明需要进一步的研究和调查。虽然这延缓了使用这些强大工具的进程,但我们仍在继续了解干细胞及其副产品的功能和意义。随着外泌体和PRP成为非细胞疗法的新重点,我们仍然能够应用这些方法来改善慢性皮肤病,如慢性伤口、疤痕、雄激素性脱发(ANA)和美学。 结论 尽管再生医学领域前景广阔,有各种新颖的添加物,但仍有许多工作要做,如监管障碍、安全问题以及分离、储存、剂量和应用标准化的需要。
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引用次数: 0
Regulatory Aspects of Regenerative Medicine in the United States and Abroad 再生医学在美国和国外的监管问题
Pub Date : 2024-08-07 DOI: 10.1002/der2.244
Dana Jaalouk, Anesh Prasai, David J. Goldberg, Jane Y. Yoo

Background

With the rising demand for natural-looking aesthetic improvements, regenerative aesthetic medicine (RAM) has become essential for addressing aging, damage, and imperfections. The regulatory landscape overseeing RAM is dynamic, evolving with new technologies to ensure safety and efficacy.

Objective

This study reviews and compares regulatory frameworks for RAM across North America, Europe, Asia, Australia, and Latin America.

Methods

Regulations in the United States, European Union (EU), Australia, Singapore, South Korea, Brazil, Argentina, and Mexico were reviewed, focusing on risk-based approaches, the extent of manipulation, and intended use of biological components.

Results

Frameworks in the United States, EU, Australia, Singapore, and South Korea share a risk-based approach, adjusting regulations based on risks associated with biological components like stem cells and extracellular vesicles. Minimal alteration is categorized as low risk, emphasizing disease transmission prevention and material quality. Regulatory landscapes vary in Latin America. Brazil's comprehensive framework, managed by ANVISA, categorizes products by manipulation levels. Argentina's ANMAT has made progress, while Mexico lacks a unified framework, leading to unregulated operations and patient risks.

Conclusion

The diverse regulatory frameworks underscore the need for continuous collaboration between regulatory bodies, healthcare providers, and stakeholders to promote innovation and ensure safety in regenerative medicine.

背景 随着人们对美观自然的要求不断提高,再生美容医学(RAM)已成为解决衰老、损伤和瑕疵问题的关键。对再生美容医学的监管是动态的,并随着新技术的发展而不断变化,以确保其安全性和有效性。 本研究回顾并比较了北美、欧洲、亚洲、澳大利亚和拉丁美洲的 RAM 监管框架。 方法 回顾美国、欧盟(EU)、澳大利亚、新加坡、韩国、巴西、阿根廷和墨西哥的法规,重点关注基于风险的方法、操纵程度和生物成分的预期用途。 结果 美国、欧盟、澳大利亚、新加坡和韩国的框架都采用基于风险的方法,根据干细胞和细胞外囊泡等生物成分的相关风险调整法规。最小改动被归类为低风险,强调预防疾病传播和材料质量。拉丁美洲的监管情况各不相同。巴西的综合框架由 ANVISA 管理,按操作水平对产品进行分类。阿根廷的 ANMAT 取得了进展,而墨西哥则缺乏统一的框架,导致运营不受监管,给患者带来风险。 结论 多种多样的监管框架凸显了监管机构、医疗保健提供商和利益相关者之间持续合作的必要性,以促进创新并确保再生医学的安全性。
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引用次数: 0
Introduction to the Regenerative Medicine—PRP, Exosomes, and Stem Cells and Their Role in Aesthetics Issue 再生医学--PRP、外泌体和干细胞及其在美学中的作用》简介
Pub Date : 2024-08-07 DOI: 10.1002/der2.255
Michael H. Gold
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引用次数: 0
Applications of Plasma-Rich Plasma, Exosomes, and Stem Cells in Aesthetics: A Narrative Review 富血浆、外泌体和干细胞在美学中的应用:叙述性综述
Pub Date : 2024-07-30 DOI: 10.1002/der2.250
Glynis Ablon, Zoë Indigo Smith, Girish (Gilly) Munavalli

Introduction

Plasma-rich plasma (PRP), exosomes, and stem cells represent promising new treatments for facial rejuvenation and to enhance other cosmetic procedures. Although these treatments are rapidly advancing, there are no universally accepted treatment protocols for their use. The goal of the following review is to describe some of the possible benefits of PRP, exosomes, and stem cells in aesthetic medicine.

Results

A review of available studies showed that potential uses of PRP include wound healing after facial surgery, facial rejuvenation, androgenetic alopecia, acne scars, striae distensae, and vitiligo. Exosomes may provide beneficial treatment for skin rejuvenation, scar reduction, hyperpigmentation, and hair growth. Stem cells show promise for androgenetic alopecia, scar improvement, and treatment of photoaged skin. These new technologies may be used alone, but are often combined with existing aesthetic treatments.

Conclusion

PRP, exosomes, and stem cells may play an important role in restoring youthful tissue structure and function. Interpretation of some study results is sometimes challenged by the lack of standardized treatment protocols, including routes of application and dosing. When combined with other devices and techniques, results are sometime unclear as to which treatment plays the greater role.

引言 富血浆血浆(PRP)、外泌体和干细胞是面部年轻化和增强其他美容手术效果的新疗法,前景广阔。虽然这些疗法发展迅速,但目前还没有普遍接受的治疗方案。以下综述旨在描述 PRP、外泌体和干细胞在美容医学中可能带来的一些益处。 结果 对现有研究的回顾表明,PRP的潜在用途包括面部手术后的伤口愈合、面部年轻化、雄激素性脱发、痤疮疤痕、条纹和白癜风。外泌体可为嫩肤、减少疤痕、色素沉着和生发提供有益的治疗。干细胞有望治疗雄激素性脱发、改善疤痕和光老化皮肤。这些新技术可以单独使用,但通常会与现有的美容疗法相结合。 结论 PRP、外泌体和干细胞可在恢复年轻组织结构和功能方面发挥重要作用。由于缺乏标准化的治疗方案,包括应用途径和剂量,有时会影响对一些研究结果的解读。当与其他设备和技术相结合时,研究结果有时并不清楚哪种治疗方法发挥了更大的作用。
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引用次数: 0
Complications After Exosome Treatment for Aesthetic Skin Rejuvenation 外泌体治疗美容嫩肤后的并发症
Pub Date : 2024-07-30 DOI: 10.1002/der2.242
William J. Nahm, Sukruthi Thunga, Jane Yoo

Background

Exosomes have gained significant attention in aesthetic dermatology for their potential in skin rejuvenation. Despite numerous studies investigating the use of exosomes in aesthetic applications, no adverse events have been reported thus far. This case series presents patients with noticeable adverse effects following the application of exosomes to the skin for aesthetic purposes in South Korea.

Methods

A consortium of concerned aesthetic dermatologists from South Korea provided a case series of patients who developed complications after receiving exosome treatments for skin rejuvenation. The case series included eight female patients, ranging in age from 26 to 52 years old, who developed delayed-onset granulomatous lesions at the treatment sites.

Results

All patients in the case series developed erythematous, indurated papules or nodules at the sites of exosome injections, with onset ranging from 2 weeks to 3 months posttreatment. Histopathological examination of biopsied lesions revealed necrotizing granulomas not related to mycobacterial infections. The patients' response to topical and oral steroids, as well as other treatments, varied.

Conclusion

Although exosome-based therapies hold great promise in aesthetic dermatology, this case series highlights the potential for delayed-onset granulomatous complications following exosome treatments for skin rejuvenation. Standardized protocols for exosome isolation and purification, as well as rigorous safety and efficacy standards, are needed to ensure the successful implementation of exosome-based products in clinical settings.

背景 外泌体在皮肤美容方面具有潜在的嫩肤作用,因此备受关注。尽管有许多研究调查了外泌体在美容方面的应用,但迄今为止还没有关于其不良反应的报道。本系列病例介绍了韩国患者在为美容目的在皮肤上应用外泌体后出现的明显不良反应。 方法 由韩国相关美容皮肤科医生组成的联盟提供了一系列病例,这些患者在接受外泌体治疗嫩肤后出现了并发症。该系列病例包括 8 名女性患者,年龄从 26 岁到 52 岁不等,她们在治疗部位出现了迟发性肉芽肿病变。 结果 所有病例系列中的患者都在注射外泌体的部位出现了红斑、丘疹或结节,发病时间从治疗后 2 周到 3 个月不等。活组织病理学检查显示,坏死性肉芽肿与霉菌感染无关。患者对局部和口服类固醇以及其他治疗方法的反应各不相同。 结论 尽管基于外泌体的疗法在皮肤美容方面大有可为,但本系列病例强调了外泌体治疗嫩肤后可能出现迟发性肉芽肿并发症。为确保外泌体产品在临床上的成功应用,需要标准化的外泌体分离和纯化方案以及严格的安全性和有效性标准。
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引用次数: 0
Exploring the Efficacy and Safety of Interleukin-23 Inhibitors in Dissecting Cellulitis of the Scalp: A Comprehensive Review 探索白细胞介素-23 抑制剂在头皮剥脱性蜂窝组织炎中的疗效和安全性:全面综述
Pub Date : 2024-07-30 DOI: 10.1002/der2.247
Khalid Nabil Nagshabandi, Asem Shadid, Mohammed Al-Mashali

Background

Dissecting cellulitis of the scalp (DCS), also known as perifolliculitis capitis abscedens et suffodiens or Hoffmann disease, is a rare chronic inflammatory scalp condition with an unknown etiology. The US Food and Drug Administration (FDA) has recently approved multiple interleukin-23 (IL-23) inhibitors for chronic-plaque psoriasis, and their off-label use has shown promise in treating various dermatological conditions, including DCS. This review assesses the efficacy and safety of IL-23 inhibitors for DCS, aiming to support potential FDA approval for severe refractory cases.

Methods

A comprehensive literature search was conducted in February 2024 using MEDLINE, PUBMED, and Google Scholar with the keywords “Dissecting cellulitis,” “DCS,” “Interleukin-23 inhibitors,” “IL-23,” and “Biologics.” The search focused on identifying studies reporting the use of IL-23 inhibitors in DCS treatment.

Results

The search identified five cases where IL-23 inhibitors were used to treat DCS. All patients were male, aged 17–65 years, with multiple comorbidities in four cases, primarily hidradenitis suppurativa and acne conglobata. The IL-23 inhibitors Risankizumab, Guselkumab, and Tildrakizumab were used, resulting in significant clinical improvement, near-complete remission, and hair regrowth. Additionally, psychosocial improvements were noted in two cases, with no reported adverse effects.

Conclusion

IL-23 inhibitors have shown remarkable efficacy in treating severe DCS, with significant clinical and psychosocial improvements and a favorable safety profile. These findings support the consideration of FDA approval for IL-23 inhibitors as a treatment option for refractory DCS cases, offering hope for patients with this challenging condition.

背景头皮剥脱性蜂窝织炎(DCS)又称毛囊周围炎(perifolliculitis capitis abscedens et suffodiens)或霍夫曼病(Hoffmann disease),是一种罕见的慢性头皮炎症,病因不明。美国食品和药物管理局(FDA)最近批准了多种白细胞介素-23(IL-23)抑制剂用于治疗慢性斑块型银屑病,这些抑制剂的标示外使用已显示出治疗包括DCS在内的各种皮肤病的前景。本综述评估了IL-23抑制剂治疗DCS的疗效和安全性,旨在支持FDA对严重难治性病例的潜在批准。 方法 2024 年 2 月,我们使用 MEDLINE、PUBMED 和 Google Scholar 进行了一次全面的文献检索,关键词为 "裂解性蜂窝组织炎"、"DCS"、"白细胞介素-23 抑制剂"、"IL-23 "和 "生物制剂"。搜索的重点是确定报道在 DCS 治疗中使用 IL-23 抑制剂的研究。 结果 搜索发现了五例使用IL-23抑制剂治疗DCS的病例。所有患者均为男性,年龄在 17-65 岁之间,其中四例患者患有多种并发症,主要是化脓性扁平苔藓和痤疮。使用IL-23抑制剂Risankizumab、Guselkumab和Tildrakizumab后,患者的临床症状明显改善,病情接近完全缓解,毛发也重新生长。此外,两个病例的社会心理也得到了改善,且无不良反应报告。 结论 IL-23 抑制剂在治疗重度 DCS 方面疗效显著,临床和社会心理均有明显改善,安全性良好。这些研究结果支持 FDA 考虑批准 IL-23 抑制剂作为治疗难治性 DCS 病例的一种选择,为这种具有挑战性病情的患者带来了希望。
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引用次数: 0
Nd:YAG Technology for Laser Hair Removal: What's New? 用于激光脱毛的 Nd:YAG 技术:有什么新技术?
Pub Date : 2024-07-26 DOI: 10.1002/der2.249
Thanyathorn Nuchanatanon, Natthachat Jurairattanaporn, Vasanop Vachiramon

Background

Since its inception, the Neodymium-doped yttrium aluminum garnet (Nd:YAG) 1064-nm laser has been widely used for the treatment of hair removal. Selective photothermolysis forms the basis of its function. Without harming the skin, the laser damages the hair follicle, offering safety and potentially positive outcomes. Many years after its debut, newly developed Nd:YAG laser technology and additional indicators have been found.

Methods

The quality of the evidence was evaluated using PubMed and Google Scholar searches. A selection of articles published between 2019 and 2024 underwent a retrospective review.

Results

Updated technology, including the “in-motion” technique, submillisecond pulse, and the combination of alexandrite and Nd:YAG lasers, achieves effective hair reduction with a higher safety profile. Other effects of the Nd:YAG laser on sweat glands, its bactericidal effects, and its long-term effects on laser providers are discussed in this literature.

Conclusion

With minimal short- and long-term side effects, the latest technology and techniques of Nd:YAG laser treatment at a wavelength of 1064 nm have been shown to be beneficial and promising for hair removal.

自诞生以来,掺钕钇铝石榴石(Nd:YAG)1064 纳米激光就被广泛用于脱毛治疗。选择性光热解是其功能的基础。在不伤害皮肤的情况下,激光会破坏毛囊,从而提供安全性和潜在的积极效果。Nd:YAG激光技术问世多年后,人们发现了新开发的Nd:YAG激光技术和其他指标。对2019年至2024年期间发表的部分文章进行了回顾性审查。更新的技术,包括 "移动中 "技术、亚毫秒脉冲以及紫翠宝石激光器和Nd:YAG激光器的组合,可实现有效的脱毛效果,且安全性更高。本文献还讨论了 Nd:YAG 激光对汗腺的其他影响、杀菌作用以及对激光提供者的长期影响。波长为 1064 纳米的 Nd:YAG 激光治疗的最新技术和工艺已被证明对脱毛有益且前景广阔,其短期和长期副作用极小。
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引用次数: 0
Advancements in Cosmetics and Aesthetics: A Comprehensive Review 化妆品和美学的进步:全面回顾
Pub Date : 2024-07-19 DOI: 10.1002/der2.245
Mohamad Goldust, Leslie Baumann, Michael H. Gold, Marina Landau

Objective

This article provides a comprehensive overview of recent advancements in cosmetic dermatology and aesthetics. It covers topics including dermal fillers, botulinum toxin (BTX anti-aging cosmeceuticals, artificial intelligence (AI) applications, and energy-based devices.

Methods

The review summarizes the current literature on dermal fillers, BTX, cosmeceuticals, AI applications, and energy-based devices. It explores emerging technologies, new treatment methods, and ongoing research in these areas. The sources of data include peer-reviewed journals, clinical trials, and expert opinions to provide a thorough understanding of recent developments and future trends.

Results

Dermal fillers, particularly hyaluronic acid (HA), are popular in cosmetic treatments, with innovations like Bioorthogonal strategies and thiomer-based technology emerging. Biostimulators such as poly-l-lactic acid and calcium hydroxyapatite promote neo-collagenesis. BTX remains a cosmetic standard, with new recombinant toxins, hybrid BTXs, and delivery methods enhancing safety and efficacy. Anti-aging trends include cellular senescence-targeting treatments like exosomes, NMN, and PDRN, which need further validation. AI improves diagnosis, personalized treatments, and patient consultations but faces data privacy and bias challenges. Advanced energy-based devices (RF, HIFU, lasers) and treatments like cryolipolysis and MFU-V enhance skin rejuvenation and body contouring.

Conclusion

Recent advancements in cosmetic dermatology and aesthetics, including innovative dermal fillers, BTX developments, anti-aging cosmeceuticals, AI applications, and energy-based devices, are transforming the field. These innovations provide enhanced treatment options and improved patient outcomes, although further research is necessary to validate efficacy and address emerging challenges. The future of cosmetic dermatology is promising, with ongoing technological advancements driving continuous improvements in aesthetic medicine.

本文全面概述了美容皮肤科和美学领域的最新进展。文章涉及的主题包括皮肤填充剂、肉毒杆菌毒素(BTX)抗衰老药妆、人工智能(AI)应用和基于能量的设备。 方法 该综述总结了有关皮肤填充剂、BTX、药妆、人工智能应用和能量设备的现有文献。它探讨了这些领域的新兴技术、新治疗方法和正在进行的研究。数据来源包括同行评审期刊、临床试验和专家意见,以提供对最新发展和未来趋势的全面了解。 成果 皮肤填充剂,尤其是透明质酸(HA),在美容治疗中很受欢迎,并出现了生物正交策略和基于硫代物的创新技术。聚乳酸和羟基磷灰石钙等生物刺激剂可促进新胶原蛋白的生成。BTX 仍是美容标准,新的重组毒素、混合 BTX 和给药方法提高了安全性和有效性。抗衰老趋势包括外泌体、NMN 和 PDRN 等细胞衰老靶向疗法,这些疗法需要进一步验证。人工智能改善了诊断、个性化治疗和患者咨询,但也面临着数据隐私和偏见方面的挑战。先进的能量设备(射频、HIFU、激光)和治疗方法(如冷冻溶脂和 MFU-V)可促进皮肤年轻化和身体塑形。 结论 皮肤美容和美学领域的最新进展,包括创新皮肤填充剂、BTX 开发、抗衰老药妆、人工智能应用和基于能量的设备,正在改变这一领域。这些创新技术提供了更多的治疗选择,改善了患者的治疗效果,但还需要进一步的研究来验证疗效和应对新出现的挑战。随着技术的不断进步,美容医学也在不断改进,美容皮肤科的未来充满希望。
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引用次数: 0
Alexandrite Laser for Hair Reduction: Updates and What Is New 用于脱毛的亚历山大激光器:更新和新内容
Pub Date : 2024-07-12 DOI: 10.1002/der2.246
Diala Haykal

Introduction

In the realm of dermatological advancements, the alexandrite laser has carved out a significant niche in hair removal treatments. Operating at a 755 nm wavelength, it is adept at targeting melanin in hair follicles, making it particularly suitable for individuals with fair skin tones. Despite its advantages, the application of alexandrite lasers presents challenges, especially in individuals with darker skin tones due to a higher risk of adverse effects.

Objective

This comprehensive review explores the literature to examine the role and advancements of the alexandrite laser within the evolving landscape of laser hair removal. It discusses the technology's strengths, limitations, and prospects, aiming to provide a comprehensive understanding of its current state and identify avenues for further research.

Methods

Comprehensive searches were conducted in databases such as PubMed, Google Scholar, and the Cochrane Library from January 1990 to April 2024. The search included keywords and MeSH terms like ‘laser therapy,’ ‘hair reduction,’ ‘phototherapy,’ ‘hair removal,’ and ‘alexandrite.’ Studies focusing specifically on alexandrite lasers for hair removal, including reviews and clinical trials, were included.

Results

The alexandrite laser is highly effective for light skin tones but poses risks for darker skin. Nd:YAG lasers are safer for darker skin but may require more sessions for fine or light-colored hair. Diode lasers are versatile for various skin types but less efficient for very dark or very light skin. IPL is adaptable but often needs more sessions and has higher side effect risks. Long-term studies show sustained hair reduction with alexandrite lasers, resulting in high patient satisfaction. Side effects are generally mild and temporary, such as redness and swelling. Recent advancements in alexandrite laser technology, such as integration with other laser types, larger spot sizes, and improved cooling systems, have enhanced its safety and efficacy. Combining alexandrite with Nd:YAG lasers has expanded its applicability to darker skin tones. These innovations, along with high-frequency treatments and shorter pulse durations, promise improved patient outcomes. However, considerations of cost and the need for multiple sessions must be weighed.

Conclusion

No single hair removal technology is universally superior; the optimal choice varies based on individual s

导言:在皮肤病治疗领域,紫翠宝石激光在脱毛治疗中占据了重要地位。它的波长为 755 纳米,善于瞄准毛囊中的黑色素,因此特别适合肤色白皙的人。亚历山大石英激光虽然有其优点,但在应用中也面临着挑战,尤其是在肤色较深的人身上,因为不良反应的风险较高。 本综述通过对文献的探讨,研究了紫翠宝石激光在不断发展的激光脱毛领域中的作用和进步。它讨论了该技术的优势、局限性和前景,旨在提供对其现状的全面了解,并确定进一步研究的途径。 方法 从 1990 年 1 月到 2024 年 4 月,在 PubMed、Google Scholar 和 Cochrane Library 等数据库中进行了全面检索。搜索包括关键词和 MeSH 术语,如 "激光疗法"、"脱毛"、"光疗"、"脱毛 "和 "紫翠宝石"。其中包括专门针对紫翠宝石激光脱毛的研究,包括综述和临床试验。 结果 紫翠宝石激光对浅色皮肤非常有效,但对深色皮肤有风险。掺钕钇钕石榴石(Nd:YAG)激光对深色皮肤更安全,但对于细毛或浅色毛发可能需要更多疗程。二极管激光器适用于各种皮肤类型,但对深肤色或浅肤色皮肤的效果较差。强脉冲光适应性强,但通常需要更多疗程,副作用风险较高。长期研究表明,紫翠宝石激光可持续脱毛,患者满意度高。副作用通常是轻微和暂时的,如发红和肿胀。翠绿宝石激光技术的最新进展,如与其他激光类型的整合、更大的光斑尺寸和改进的冷却系统,提高了其安全性和有效性。将变石榴石激光与 Nd:YAG 激光相结合,使其更适用于深肤色皮肤。这些创新技术以及高频治疗和更短的脉冲持续时间有望改善患者的治疗效果。不过,必须权衡成本和多次治疗的需要。 结论 没有任何一种脱毛技术是放之四海而皆准的,最佳选择取决于个人的皮肤和毛发特征。翠绿宝石激光技术的进步扩大了其适用范围,提高了有效性和患者的舒适度。正在进行的研究和技术发展有望进一步完善这些技术,为持久脱毛带来革命性的变化,使其成为一种越来越容易获得和可持续的选择。
{"title":"Alexandrite Laser for Hair Reduction: Updates and What Is New","authors":"Diala Haykal","doi":"10.1002/der2.246","DOIUrl":"https://doi.org/10.1002/der2.246","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>In the realm of dermatological advancements, the alexandrite laser has carved out a significant niche in hair removal treatments. Operating at a 755 nm wavelength, it is adept at targeting melanin in hair follicles, making it particularly suitable for individuals with fair skin tones. Despite its advantages, the application of alexandrite lasers presents challenges, especially in individuals with darker skin tones due to a higher risk of adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This comprehensive review explores the literature to examine the role and advancements of the alexandrite laser within the evolving landscape of laser hair removal. It discusses the technology's strengths, limitations, and prospects, aiming to provide a comprehensive understanding of its current state and identify avenues for further research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Comprehensive searches were conducted in databases such as PubMed, Google Scholar, and the Cochrane Library from January 1990 to April 2024. The search included keywords and MeSH terms like ‘laser therapy,’ ‘hair reduction,’ ‘phototherapy,’ ‘hair removal,’ and ‘alexandrite.’ Studies focusing specifically on alexandrite lasers for hair removal, including reviews and clinical trials, were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The alexandrite laser is highly effective for light skin tones but poses risks for darker skin. Nd:YAG lasers are safer for darker skin but may require more sessions for fine or light-colored hair. Diode lasers are versatile for various skin types but less efficient for very dark or very light skin. IPL is adaptable but often needs more sessions and has higher side effect risks. Long-term studies show sustained hair reduction with alexandrite lasers, resulting in high patient satisfaction. Side effects are generally mild and temporary, such as redness and swelling. Recent advancements in alexandrite laser technology, such as integration with other laser types, larger spot sizes, and improved cooling systems, have enhanced its safety and efficacy. Combining alexandrite with Nd:YAG lasers has expanded its applicability to darker skin tones. These innovations, along with high-frequency treatments and shorter pulse durations, promise improved patient outcomes. However, considerations of cost and the need for multiple sessions must be weighed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>No single hair removal technology is universally superior; the optimal choice varies based on individual s","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Dermatological Reviews
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