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Health reform in China: Developments and future prospects 中国的医疗改革:发展与未来展望
Pub Date : 2022-09-27 DOI: 10.1002/hcs2.19
Jiwei Qian

In 2009, China initiated a new round of health reform to establish a well-functioning health system. The 2009 health reform did make some significant achievements in improving affordability and accessibility. In particular, social health insurance has been expanded significantly and various social health insurance plans have covered over 95% of total population in China by 2011. The Chinese government also has significantly increased fiscal input for health financing. However, affordability remains a serious concern as the social health insurers, as purchasers, were not very effective in containing the growth of health expenditure. Accessibility to primary care and public health is another concern. In this context, health governance reforms are necessary to address affordability and accessibility issues. Health governance set rules for key actors of the health system (including service providers, health insurers and government departments) by taking into account the strategies and incentives of these actors in their interactions. In recent years, a series of reforms in health governance have been initiated. Some progresses have been achieved. For the next stage of health reform, issues including how to further reform the governance structure of medical institutions and how to improve resource allocation in the health system are critical.

2009年,中国启动了新一轮卫生改革,建立了一个运行良好的卫生体系。2009年的医疗改革确实在提高负担能力和可及性方面取得了一些重大成就。特别是社会健康保险大幅度扩大,到2011年,各类社会健康保险覆盖面已达到95%以上。中国政府还大幅增加了卫生筹资的财政投入。然而,负担能力仍然是一个严重问题,因为作为购买者的社会健康保险公司在控制保健支出增长方面不是很有效。初级保健和公共卫生的可及性是另一个令人关切的问题。在这方面,必须进行卫生治理改革,以解决可负担性和可及性问题。卫生治理为卫生系统的关键行为者(包括服务提供者、卫生保险公司和政府部门)制定规则,考虑到这些行为者在相互作用中的战略和动机。近年来,开展了一系列卫生治理改革。已经取得了一些进展。对于下一阶段的卫生改革,包括如何进一步改革医疗机构的治理结构和如何改善卫生系统的资源配置等问题是至关重要的。
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引用次数: 2
Decision-making for early major amputation in selected diabetic foot ulcer patients with peripheral vascular disease 糖尿病足溃疡合并周围血管病变患者早期大截肢的决策
Pub Date : 2022-09-19 DOI: 10.1002/hcs2.17
Lim York Tee Gorden, Ying Fangting Ariel, Ho Pei, Lingyan Meng, N. G. Yi Zhen, Nicholas Graves

Objective

To estimate the costs from delaying major amputation in patients with concurrent diabetic foot ulcer and peripheral vascular disease. We seek to model economic benefits from saved costs from promoting timely major amputations among these patients.

Methods

Retrospective modeling using data from National University Hospital, Singapore. We identified patients who might have delayed major amputations by applying a hierarchical clustering algorithm. We then modeled the transitions of all patients over time with a Markov process using a number of relevant health states to enable estimation of cost outcomes. We next summarized the expected changes to the bed days used and cost outcomes arising from reassigning some patients who may have had a delayed amputation to timely amputation. The findings from the sample were scaled to reflect national incidence rates for this disease for the years 2014–2019 in Singapore.

Results and Conclusions

Nine of the 137 patients (6.57%) would be suitable for a major amputation at 3 months, yet in reality, their amputation was delayed. Based on this, and assuming a timely amputation is done for the entire population of patients in Singapore we expect annual savings of 264,791 bed days and $211 million in costs. These findings are preliminary and uncertain. The value of this paper is to show a method for estimating outcomes, report the findings from a small sample, and stimulate future research. New cohort studies might be designed to capture a wider range of outcomes and recruit a larger sample of individuals.

目的评估糖尿病足溃疡合并周围血管病变患者延迟大截肢的成本。我们寻求通过在这些患者中促进及时进行重大截肢而节省成本的经济效益模型。方法利用新加坡国立大学医院的资料进行回顾性建模。我们通过应用分层聚类算法确定可能延迟主要截肢的患者。然后,我们使用一些相关的健康状态,用马尔可夫过程对所有患者随时间的转变进行建模,以实现成本结果的估计。接下来,我们总结了由于将一些可能延迟截肢的患者重新分配为及时截肢而导致的预期使用天数变化和成本结果。样本的调查结果进行了缩放,以反映新加坡2014-2019年这种疾病的全国发病率。结果与结论137例患者中有9例(6.57%)在3个月时适合进行大截肢,但实际情况是延迟截肢。在此基础上,假设新加坡所有患者都能及时截肢,我们预计每年可节省264,791个住院日和2.11亿美元的费用。这些发现是初步的和不确定的。本文的价值在于展示了一种估计结果的方法,报告了小样本的发现,并激发了未来的研究。新的队列研究可能会被设计成获得更广泛的结果,并招募更大的个体样本。
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引用次数: 2
Evaluating the integrated antimicrobial stewardship system of China by the assessment tool of WHO 用世卫组织评估工具评价中国抗菌药物综合管理制度
Pub Date : 2022-09-13 DOI: 10.1002/hcs2.16
Yonghong Xiao, Wei Yu, Tingting Xiao, Ping Shen

Objective

To fully understand the overall system and implementation of antimicrobial stewardship (AMS) at different levels in China, an evaluation according to the integrated AMS evaluation tool developed by World Health Organization (WHO) was conducted.

Methods

A comprehensive search on the AMS relevant government policies, regulations, scientific research results, public and social activities was conducted, and the implementation of AMS strategies in national, subnational and hospital level were evaluated by the standards of the WHO.

Results

The results shew that the system construction, technical infrastructure and actions of AMS in China at the national level is relatively satisfied, but the AMS system needs to be further strengthened at the subnational and the medical institutional level, especially the integration of multidisciplinary teams and relevant departments; the implementation of professional intervention strategies, national education and publicity, professional education and training are relatively weak. AMS implementation is mainly promoted at the national level, and AMS in primary medical institutions is almost missing. It is necessary to carry out AMS at the provincial level and medical institutions as soon as possible. The focus is to establish a professional AMS team, prepare AMS guideline, implement AMS strategy, raise public awareness and ensure the long-term and sustainable development of AMS in the country.

Conclusion

The Chinese government has established a system for AMS, and implemented a multisectoral coordinative mechanism. However, at the subnational and district levels, an AMS system and practice should be set up soon to promote the rational use of antibiotics.

目的采用世界卫生组织(WHO)开发的抗菌药物管理综合评价工具,对中国各级抗菌药物管理的总体制度和实施情况进行评价。方法对医疗辅助系统相关的政府政策法规、科研成果、公众活动和社会活动进行综合检索,并采用世界卫生组织(WHO)标准对医疗辅助系统战略在国家、地方和医院层面的实施情况进行评价。结果结果表明,在国家层面上,中国辅助医疗系统的体系建设、技术基础设施和行动较为令人满意,但在地方和医疗机构层面,辅助医疗系统还有待进一步加强,特别是多学科团队和相关部门的整合;专业干预策略的实施,国民教育宣传、专业教育培训相对薄弱。辅助医疗服务的实施主要在国家层面推进,基层医疗机构的辅助医疗服务几乎缺失。尽快在省级和医疗机构开展辅助医疗服务。重点是建立专业的医疗辅助服务团队,制定医疗辅助服务指南,实施医疗辅助服务战略,提高公众意识,确保医疗辅助服务在国内的长期可持续发展。中国政府建立了医疗辅助医疗制度,建立了多部门协调机制。然而,在国家以下和地区一级,应尽快建立辅助医疗系统和做法,以促进抗生素的合理使用。
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引用次数: 0
Microbiosis in lung allotransplantation and xenotransplantation: State of the art and future perspective 肺同种异体移植和异种移植中的微生物学:现状和未来展望
Pub Date : 2022-09-13 DOI: 10.1002/hcs2.15
Jiao Guohui, Wu Kun, Tian Dong, Zhang Ji, Liu Dong, Wei Dong, Chen Jingyu

The respiratory tract is known to harbor a microbial community including bacteria, viruses, and fungi. New techniques contribute enormously to the identification of unknown or culture-independent species and reveal the interaction of the community with the host immune system. The existing respiratory microbiome and substantial equilibrium of the transplanted microbiome from donor lung grafts provide an extreme bloom of dynamic changes in the microenvironment in lung transplantation (LT) recipients. Dysbiosis in grafts are not only related to the modified microbial components but also involve the kinetics of the host-graft “talk,” which signifies the destination of graft allograft injury, acute rejection, infection, and chronic allograft dysfunction development in short- and long-term survival. Microbiome-derived factors may contribute to lung xenograft survival when using genetically multimodified pig-derived organs. Here, we review the most advanced knowledge of the dynamics and resilience of microbial communities in transplanted lungs with various pretransplant indications. Conceptual and analytical points of view have been illustrated along the time series, gaining insight into the microbiome and lung grafts. Future endeavors on precise tools, sophisticated models, and novel targeted regimens are needed to improve the long-term survival in these patients.

众所周知,呼吸道内有微生物群落,包括细菌、病毒和真菌。新技术对鉴定未知或培养独立的物种做出了巨大贡献,并揭示了社区与宿主免疫系统的相互作用。来自供体肺移植物的现有呼吸微生物组和移植微生物组的大量平衡提供了肺移植(LT)受者微环境动态变化的极端繁荣。移植物的生态失调不仅与修饰的微生物成分有关,还涉及宿主-移植物“对话”的动力学,这意味着移植物损伤的目的地,急性排斥反应,感染,以及短期和长期生存中的慢性移植物功能障碍发展。当使用遗传修饰的猪源性器官时,微生物来源的因素可能有助于肺移植存活。在这里,我们回顾了各种移植前适应症移植肺中微生物群落的动态和弹性的最新知识。概念和分析的观点已经说明了沿着时间序列,获得洞察微生物组和肺移植。为了提高这些患者的长期生存率,未来需要开发精确的工具、复杂的模型和新颖的靶向治疗方案。
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引用次数: 0
Primary health care in China: A decade of development after the 2009 health care reform 中国初级卫生保健:2009年医疗改革后的十年发展
Pub Date : 2022-09-12 DOI: 10.1002/hcs2.14
You Wu, Zeyu Zhang, Ning Zhao, Yue Yan, Lina Zhao, Qi Song, Rong Ma, Changfeng Li, Jinyi Li, Suibin Liu, Xinran Bi, Zongjiu Zhang

Over 40 years ago, primary health care (PHC) was defined in the Alma-Ata Declaration as a critical component of the health care system to address the basic health demand of the people. In China, the Government attaches great importance to health care at the primary level. After the launch of the historical Reform of the Medical and Health Care System in 2009, the PHC system in China has witnessed major progress and breakthroughs, especially in its steadily increased capacity, continuously improved accessibility, and betterment in equality. In this review, we summarized published literatures and official policies, synthesized data from the electronic registration information system of the National Health Commission, national statistical reports, and yearbooks in health care. The review is intended to describe the systematic development of PHC in China in the last decade. The main results include: the solid national policy foundation, increasing number of PHC institutions and workforce, better training of PHC professionals, major achievements in primary health indicators, government financial support to PHC institutions, improved PHC budgeting and insurance coverage, and the advancement of supporting technologies. Challenges and prospects are also discussed.

40多年前,《阿拉木图宣言》将初级卫生保健定义为卫生保健系统的一个关键组成部分,以满足人民的基本卫生需求。在中国,政府非常重视初级保健。自2009年启动具有历史意义的医药卫生体制改革以来,中国初级卫生保健制度取得了重大进展和突破,特别是能力水平稳步提高、可及性不断提高、公平性不断提高。在这篇综述中,我们总结了已发表的文献和官方政策,综合了来自国家卫生健康委员会电子注册信息系统、国家统计报告和卫生保健年鉴的数据。本文旨在对近十年来中国初级保健的系统发展进行综述。主要成果包括:国家政策基础牢固,初级保健机构和人员数量增加,初级保健专业人员培训加强,初级保健指标取得重大成就,政府对初级保健机构的财政支持,初级保健预算和保险覆盖率提高,配套技术进步。讨论了面临的挑战和前景。
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引用次数: 0
The impact of infectious disease prevention behavior on quality of life: A moderated mediation model 传染病预防行为对生活质量的影响:一个有调节的中介模型
Pub Date : 2022-09-07 DOI: 10.1002/hcs2.11
Fei Wang, Pu Ge, Danyang Li, Lin Cai, Xialei Li, Xinying Sun, Yibo Wu

Objective

To explore the mechanism of infectious disease prevention behavior on quality of life, and to investigate the mediating role of self-efficacy and the moderating role of family structure.

Methods

A total of 3015 subjects were selected by multistage stratified cluster sampling.

Results

Infectious disease prevention behavior had a significant positive predictive effect on the quality of life (β = 0.08, p < 0.001), The self-efficacy of family members had a partial mediating effect on the relationship between infectious disease prevention behavior and quality of life (β = 0.01, p < 0.001). Compared to nuclear family, conjugal family (β = 0.05, p < 0.001) and single-parent family (β = 0.04, p < 0.01) could regulate the relationship between infectious disease prevention behavior and the quality of life, stem family (β = −1.53, p < 0.05), conjugal family (β = 1.63, p < 0.05), and collective family (β = −1.37, p < 0.05) could regulate the relationship between infectious disease prevention behavior and self-efficacy, conjugal family (β = 0.00, p < 0.001) could regulate the relationship between self-efficacy and quality of life.

Conclusion

Infectious disease prevention behavior can affect the quality of life through self-efficacy. Different family structures play a regulatory role in different paths, and a regulatory mediation model is established.

目的探讨传染病预防行为对生活质量的影响机制,探讨自我效能感的中介作用和家庭结构的调节作用。方法采用多阶段分层整群抽样方法,抽取3015名调查对象。结果传染病预防行为对生活质量有显著正向预测作用(β = 0.08, p < 0.001),家庭成员自我效能感对传染病预防行为与生活质量的关系有部分中介作用(β = 0.01, p < 0.001)。与核心家庭相比,夫妻家庭(β = 0.05, p < 0.001)和单亲家庭(β = 0.04, p < 0.01)可以调节传染病预防行为与生活质量的关系,骨干家庭(β = - 1.53, p < 0.05)、夫妻家庭(β = 1.63, p < 0.05)和集体家庭(β = - 1.37, p < 0.05)可以调节传染病预防行为与自我效能的关系,夫妻家庭(β = 0.00, p < 0.05)可以调节传染病预防行为与自我效能的关系。P < 0.001)可以调节自我效能感与生活质量的关系。结论传染病预防行为可通过自我效能感影响生活质量。不同的家庭结构在不同的路径上发挥调节作用,并建立了调节中介模型。
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引用次数: 0
Investigating the relationships between emotional experiences and behavioral responses amid the Covid-19 pandemic: A cross-sectional survey 调查新冠肺炎大流行期间情绪体验与行为反应之间的关系:一项横断面调查
Pub Date : 2022-09-06 DOI: 10.1002/hcs2.13
Tingting Wang, Xin Zheng, Zhaomeng Niu, Pengwei Hu, Ruiqi Dong, Zhihan Tang

The Covid-19 pandemic produced a complex combination of intense negative emotions among the general public, influencing people's coping reactions toward the pandemic. Yet each discrete emotion may affect people's behaviors in different ways. Unveiling the specific emotion–behavior relationships can provide valuable implications for designing effective intervention programs. Through the lens of the appraisal theory of emotion, we assessed the relationships between negative emotions and pandemic-related behaviors among the Chinese population midst the early outbreak of the pandemic. An anonymous online survey was distributed to mainland Chinese participants (n = 2976), which assessed individuals' emotional states and behavioral reactions to the pandemic. Consistent with the differential appraisal theme underlying each negative emotion as delineated by the appraisal theory, mixed relationships between emotions and pandemic-related behaviors were revealed. Specifically, anxiety was positively associated with behaviors of seeking pandemic-related information, sharing such information, and stockpiling preventive goods, yet, contrary to prediction, anxious people were reluctant to adopt preventive measures, which is maladaptive. Sad people sought information less frequently and exhibited lower intention to stockpile preventive goods; but, opposing prediction, they shared information less frequently. Angry people were more active in sharing information and in stockpiling preventive goods. These findings suggest that public health practitioners can utilize the emotion–behavior relationships to identify the vulnerable individuals who tend to adopt maladaptive coping behaviors, help them address emotional distress, and encourage their adoption of effective coping behaviors.

新冠肺炎大流行在公众中产生了强烈的负面情绪的复杂组合,影响了人们对大流行的应对反应。然而,每一种离散的情绪都可能以不同的方式影响人们的行为。揭示特定的情绪-行为关系可以为设计有效的干预方案提供有价值的启示。通过情绪评估理论的视角,我们评估了疫情早期中国人群的负面情绪与疫情相关行为之间的关系。一项匿名的在线调查被分发给中国大陆的参与者(n = 2976),评估了个人对疫情的情绪状态和行为反应。与评估理论所描述的每种负面情绪背后的差异评估主题一致,情绪与疫情相关行为之间的混合关系被揭示出来。具体而言,焦虑与寻求疫情相关信息、分享此类信息和储存预防用品的行为呈正相关,但与预测相反,焦虑的人不愿意采取预防措施,这是不适应的。悲伤的人寻求信息的频率较低,储存预防用品的意愿也较低;但是,与预测相反,他们共享信息的频率较低。愤怒的人们更积极地分享信息和储存预防用品。这些发现表明,公共卫生从业者可以利用情绪-行为关系来识别倾向于采取不适应应对行为的弱势个体,帮助他们解决情绪困扰,并鼓励他们采取有效的应对行为。
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引用次数: 0
A review of healthy aging in China, 2000–2019 2000-2019年中国健康老龄化研究综述
Pub Date : 2022-08-23 DOI: 10.1002/hcs2.9
Litao Zhao

In 2021, China became an aged society when the share of its elderly population (age 65 years and above) exceeded 14%. In China, as in other upper-middle-income and high-income countries, life expectancy gains are increasingly concentrated at older ages with below-average health and economic activity. Governments worldwide are hence actively pursuing healthy and productive aging. Healthy aging by some measures is taking place. Similar with other upper-middle-income countries, China's young old in their 60s are healthier than the same age group two decades ago. The picture is more complex for the older age group (70 years and above). Although there is a substantial decline in leading disease burdens such as stroke and chronic obstructive pulmonary disease, diseases such as Alzheimer's and other dementia are on the rise. To meet the challenge of a rapidly aging population, China's healthy aging agenda should improve its multipronged approach that seeks to promote healthy lifestyles, enhance the healthcare system, create age-friendly communities, and tackle socioeconomic and health disparities.

到2021年,中国老年人口(65岁及以上)的比例超过14%,中国将进入老龄化社会。在中国,与其他中高收入和高收入国家一样,预期寿命的增长越来越集中在健康和经济活动低于平均水平的老年人身上。因此,世界各国政府都在积极追求健康和富有成效的老龄化。从某些方面来看,健康老龄化正在发生。与其他中高收入国家一样,中国60多岁的年轻人比20年前的同龄人更健康。老年群体(70岁及以上)的情况更为复杂。虽然中风和慢性阻塞性肺病等主要疾病负担大幅下降,但阿尔茨海默氏症和其他痴呆症等疾病的发病率却在上升。为了应对人口快速老龄化的挑战,中国的健康老龄化议程应改进其多管齐下的方法,旨在促进健康的生活方式,加强医疗体系,创建老年人友好型社区,并解决社会经济和健康差距。
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引用次数: 3
Two Singapore public healthcare AI applications for national screening programs and other examples 两个新加坡公共医疗人工智能应用于国家筛查项目和其他例子
Pub Date : 2022-08-19 DOI: 10.1002/hcs2.10
Andy Wee An Ta, Han Leong Goh, Christine Ang, Lian Yeow Koh, Ken Poon, Steven M. Miller

This article explains how two AI systems have been incorporated into the everyday operations of two Singapore public healthcare nation-wide screening programs. The first example is embedded within the setting of a national level population health screening program for diabetes related eye diseases, targeting the rapidly increasing number of adults in the country with diabetes. In the second example, the AI assisted screening is done shortly after a person is admitted to one of the public hospitals to identify which inpatients—especially which elderly patients with complex conditions—have a high risk of being readmitted as an inpatient multiple times in the months following discharge. Ways in which healthcare needs and the clinical operations context influenced the approach to designing or deploying the AI systems are highlighted, illustrating the multiplicity of factors that shape the requirements for successful large-scale deployments of AI systems that are deeply embedded within clinical workflows. In the first example, the choice was made to use the system in a semi-automated (vs. fully automated) mode as this was assessed to be more cost-effective, though still offering substantial productivity improvement. In the second example, machine learning algorithm design and model execution trade-offs were made that prioritized key aspects of patient engagement and inclusion over higher levels of predictive accuracy. The article concludes with several lessons learned related to deploying AI systems within healthcare settings, and also lists several other AI efforts already in deployment and in the pipeline for Singapore's public healthcare system.

这篇文章解释了两个人工智能系统是如何被纳入新加坡两个公共医疗保健全国性筛查项目的日常运作的。第一个例子是在国家一级的糖尿病相关眼病人口健康筛查方案的背景下进行的,目标是该国迅速增加的成人糖尿病患者。在第二个例子中,人工智能辅助筛查是在一个人被送入公立医院后不久进行的,以确定哪些住院病人——尤其是那些病情复杂的老年病人——在出院后的几个月内有多次再次住院的高风险。强调了医疗保健需求和临床操作环境影响人工智能系统设计或部署方法的方式,说明了影响人工智能系统成功大规模部署需求的多种因素,这些人工智能系统深深嵌入临床工作流程中。在第一个例子中,选择在半自动化(相对于全自动)模式下使用系统,因为评估认为这种模式更具成本效益,尽管仍然提供了实质性的生产力改进。在第二个例子中,机器学习算法设计和模型执行权衡,优先考虑患者参与和包容的关键方面,而不是更高水平的预测准确性。本文总结了与在医疗保健环境中部署人工智能系统相关的几个经验教训,并列出了新加坡公共医疗保健系统已经部署和正在部署的其他几个人工智能工作。
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引用次数: 4
Explicating the publication paradigm by bibliometric approaches: A case of interplay between nanoscience and ferroptosis 通过文献计量学方法解释出版范式:纳米科学与铁下垂之间相互作用的一个案例
Pub Date : 2022-08-09 DOI: 10.1002/hcs2.5
Zhengwei Huang, Wenhao Wang, Lei Shu, Mengqin Guo, Ying Huang, Chuanbin Wu, Xin Pan

Background

Ferroptosis has been widely investigated as an emerging drug target, while its combination with nanoscience provides bourgeoning application prospects. The development of ferroptosis regulating nanomedicines have attracted worldwide attentions in recent years. It would be meaningful to describe the relevant publication paradigm.

Methods

Herein, a bibliometric analysis was performed using the database of Web of Science Core Collection to clarify the publication paradigm. The development of related publications in the last 6 years was described, and the revolutionary trends were figured out. Ultimately, the possible future exploration directions were proposed.

Results

The bibliometric analysis of 327 documents of interest indicated that the main research focus was in multiple fields including Materials science, Science & technology, Chemistry, and Pharmacology & pharmacy. With widely cooperation and strong funding, the researchers from Chinese organizations contributed most of publications, followed with United States and Australia. Cocitation analysis revealed that several original papers reported the key molecular mechanisms of ferroptosis were considered as the foundation for subsequent studies, and some nanomedicines-related documents were taken as examples and discussed. Mining results showed that the mechanism evaluation of ferroptosis regulation therapy for cancer treatment was the hotspot. Then, several possible future explorations of ferroptosis-related nanoscience were presented and discussed.

Conclusions

The bibliometric profile of nanoscience-ferroptosis research was analyzed in detail. We believe that the bibliometric analysis could act as a robust method for explicating the publication paradigm as a certain field.

铁下垂作为一种新兴的药物靶点得到了广泛的研究,其与纳米科学的结合提供了广阔的应用前景。近年来,调控铁下垂的纳米药物的研究受到了世界各国的广泛关注。描述相关的出版范式将是有意义的。方法利用Web of Science Core Collection数据库进行文献计量学分析,厘清论文发表范式。描述了近6年来相关出版物的发展,并指出了革命趋势。最后,提出了今后可能的勘探方向。结果对327篇相关文献进行文献计量学分析,研究重点集中在材料科学、科学与应用科学等多个领域;技术、化学和药理学药店在广泛的合作和雄厚的资金支持下,中国机构的研究人员发表了最多的论文,其次是美国和澳大利亚。分析发现,一些报道铁下垂关键分子机制的原创论文可作为后续研究的基础,并以一些纳米医学相关文献为例进行讨论。研究结果表明,铁下垂调节疗法治疗肿瘤的机制评价是目前研究的热点。然后,提出并讨论了未来与铁衰相关的纳米科学的几个可能的探索方向。结论详细分析了纳米科学-铁下垂研究的文献计量学概况。我们相信,文献计量分析可以作为一个强有力的方法来解释出版范式作为一个特定的领域。
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引用次数: 1
期刊
Health Care Science
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