首页 > 最新文献

Health Care Science最新文献

英文 中文
Investigating catastrophic health expenditure among people living with HIV and AIDS in South Western Nigeria 调查尼日利亚西南部艾滋病毒感染者和艾滋病患者的灾难性医疗支出
Pub Date : 2023-12-11 DOI: 10.1002/hcs2.77
Adeyinka Adeniran, Omobola Y. Ojo, Florence C. Chieme, Yeside Shogbamimu, Helen O. Olowofeso, Imane Sidibé, Oladipupo Fisher, Monsurat Adeleke

Background

This study aimed to determine the catastrophic healthcare expenditure (CHE) among people living with HIV (PLHIV) in Lagos and to identify factors associated with CHE among them.

Methods

The study was a descriptive cross-sectional survey conducted between January and March 2021 among 578 PLHIVs drawn from various healthcare facilities in Lagos where HIV care and treatment services should be provided free of charge. Data were collected through pretested questionnaires and analyzed using Stata SE 12.

Results

The mean monthly expenditure on food was N29,282 ($53.2), while expenditure on healthcare averaged N8364 ($15.2). Nearly 60% of respondents experienced CHE, while around 30% had to borrow money to pay for some aspect of their medical treatment. Almost all (96%) had no health insurance plan. Respondents' group, personal income, perception of current health status, and the number of people in their households were significantly associated with catastrophic health expenditure p < 0.05. PLHIV in the racial/ethnic minority/migrants' group and those who earned less than ₦30,000 ($55) were statistically significantly associated with CHE at p < 0.001 with OR of 28.7 and 3.15, respectively.

Conclusions

The study, therefore, highlights the widespread financial hardship faced by PLHIV in accessing healthcare, and the need for policies to increase financial risk protection.

背景 本研究旨在确定拉各斯艾滋病病毒感染者(PLHIV)的灾难性医疗支出(CHE),并找出与他们的灾难性医疗支出相关的因素。 研究方法 本研究是一项描述性横断面调查,于 2021 年 1 月至 3 月间在拉各斯 578 名艾滋病毒感染者中进行,这些艾滋病毒感染者来自拉各斯提供免费艾滋病毒护理和治疗服务的各医疗机构。数据通过预先测试的问卷收集,并使用 Stata SE 12 进行分析。 结果 平均每月食品支出为 29282 纳克法郎(53.2 美元),医疗支出平均为 8364 纳克法郎(15.2 美元)。近 60% 的受访者经历过 CHE,约 30% 的受访者不得不借钱来支付医疗费用的某些方面。几乎所有受访者(96%)都没有医疗保险计划。受访者的群体、个人收入、对当前健康状况的看法以及家庭人口数量与灾难性医疗支出有显著相关性 p < 0.05。在统计学上,少数种族/族裔/移民组别中的艾滋病毒感染者和收入低于 30,000 英镑(55 美元)的艾滋病毒感染者与灾难性医疗支出有显著相关性(p < 0.001),OR 值分别为 28.7 和 3.15。 结论 因此,本研究强调了艾滋病毒感染者在获得医疗保健服务时普遍面临的经济困难,以及制定政策以加强经济风险保护的必要性。
{"title":"Investigating catastrophic health expenditure among people living with HIV and AIDS in South Western Nigeria","authors":"Adeyinka Adeniran,&nbsp;Omobola Y. Ojo,&nbsp;Florence C. Chieme,&nbsp;Yeside Shogbamimu,&nbsp;Helen O. Olowofeso,&nbsp;Imane Sidibé,&nbsp;Oladipupo Fisher,&nbsp;Monsurat Adeleke","doi":"10.1002/hcs2.77","DOIUrl":"10.1002/hcs2.77","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to determine the catastrophic healthcare expenditure (CHE) among people living with HIV (PLHIV) in Lagos and to identify factors associated with CHE among them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was a descriptive cross-sectional survey conducted between January and March 2021 among 578 PLHIVs drawn from various healthcare facilities in Lagos where HIV care and treatment services should be provided free of charge. Data were collected through pretested questionnaires and analyzed using Stata SE 12.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean monthly expenditure on food was N29,282 ($53.2), while expenditure on healthcare averaged N8364 ($15.2). Nearly 60% of respondents experienced CHE, while around 30% had to borrow money to pay for some aspect of their medical treatment. Almost all (96%) had no health insurance plan. Respondents' group, personal income, perception of current health status, and the number of people in their households were significantly associated with catastrophic health expenditure <i>p</i> &lt; 0.05. PLHIV in the racial/ethnic minority/migrants' group and those who earned less than ₦30,000 ($55) were statistically significantly associated with CHE at <i>p</i> &lt; 0.001 with OR of 28.7 and 3.15, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study, therefore, highlights the widespread financial hardship faced by PLHIV in accessing healthcare, and the need for policies to increase financial risk protection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 6","pages":"370-380"},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.77","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138822415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and application of standardized training effect evaluation system for new nurses in operating room 手术室新护士标准化培训效果评价体系的构建与应用
Pub Date : 2023-12-10 DOI: 10.1002/hcs2.75
Xiaoli Liu, Yanshu Wei, Jin Pei, Xiaozhou Wu

Background

This study aims to develop and validate a Structured Training Effectiveness Evaluation (STEE) tool based on the Kirkpatrick model for newly graduated registered nurses in the operating room in China.

Methods

The first phase will involve focus group and individual interviews with nursing educators and newly graduated registered nurses selected using purposive sampling. The data will be analyzed thematically to identify key components necessary to develop the STEE tool. The second phase will develop and validate the STEE tool through a panel of experts using the Delphi method. The item weights will be determined with the analytic hierarchy process technique. The third phase will involve implementation and evaluation of the STEE tool with an exploratory, nonexperimental, and comparative analysis. Descriptive and inferential statistical analyses will be performed with SPSS version 23.

Results

The STEE tool for newly graduated registered nurses in the operating room will be useful for evaluating training effectiveness during standardized training. The results obtained with this tool will clarify the effectiveness of training, thereby helping transform nursing students into competent nurses.

Conclusion

In this way, this study will provide practical guidance for improving standardized training programs and help newly graduated nurses manage their transition to the clinical work environment and remain in their posts.

本研究旨在开发并验证基于Kirkpatrick模型的中国手术室新毕业注册护士结构化培训效果评估(STEE)工具。第一阶段将涉及焦点小组和个人访谈护理教育工作者和新毕业的注册护士选择使用有目的的抽样。将对数据进行主题分析,以确定开发STEE工具所需的关键组件。第二阶段将通过专家小组使用德尔菲法开发和验证STEE工具。采用层次分析法确定项目权重。第三阶段将包括通过探索性、非实验性和比较分析来实施和评估STEE工具。描述性和推断性统计分析将与SPSS版本23进行。手术室新毕业注册护士的STEE工具将有助于在标准化培训中评估培训效果。使用此工具获得的结果将澄清培训的有效性,从而帮助将护理学生转变为合格的护士。因此,本研究将为完善规范化培训方案提供实践指导,帮助新毕业的护士顺利过渡到临床工作环境并留在岗位上。
{"title":"Construction and application of standardized training effect evaluation system for new nurses in operating room","authors":"Xiaoli Liu,&nbsp;Yanshu Wei,&nbsp;Jin Pei,&nbsp;Xiaozhou Wu","doi":"10.1002/hcs2.75","DOIUrl":"10.1002/hcs2.75","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aims to develop and validate a Structured Training Effectiveness Evaluation (STEE) tool based on the Kirkpatrick model for newly graduated registered nurses in the operating room in China.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The first phase will involve focus group and individual interviews with nursing educators and newly graduated registered nurses selected using purposive sampling. The data will be analyzed thematically to identify key components necessary to develop the STEE tool. The second phase will develop and validate the STEE tool through a panel of experts using the Delphi method. The item weights will be determined with the analytic hierarchy process technique. The third phase will involve implementation and evaluation of the STEE tool with an exploratory, nonexperimental, and comparative analysis. Descriptive and inferential statistical analyses will be performed with SPSS version 23.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The STEE tool for newly graduated registered nurses in the operating room will be useful for evaluating training effectiveness during standardized training. The results obtained with this tool will clarify the effectiveness of training, thereby helping transform nursing students into competent nurses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this way, this study will provide practical guidance for improving standardized training programs and help newly graduated nurses manage their transition to the clinical work environment and remain in their posts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 6","pages":"392-399"},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.75","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-patient suicide after telephone delivery of bad news to a suspected COVID-19 patient: What could be done to improve communication quality? 向一名疑似 COVID-19 患者电话告知坏消息后住院患者自杀:如何提高沟通质量?
Pub Date : 2023-10-26 DOI: 10.1002/hcs2.74
Natalie Tin Yau So, Olivia Miu Yung Ngan

Breaking bad news is a critical communication competency for healthcare professionals. Any disclosure of a life-threatening event, such as a malignancy diagnosis, often causes significant stress to patients. While some patients may respond with acceptance and a determination to fight their illness, research has consistently shown that cancer patients often respond to the disclosure of their diagnosis with a range of negative emotions, such as anxiety, distress, and depression [1, 2]. These reactions are often accompanied by feelings of fear, uncertainty, and a sense of loss of control over their lives. Patients may also experience denial, manifesting as reluctance to accept or discuss the diagnosis [3]. Avoidance is another common reaction, where patients may choose to avoid certain situations or people that remind them of their illness [4]. These reactions are not uncommon and are a natural response to the stress and uncertainty of cancer diagnosis.

A common ethical dilemma in breaking a cancer diagnosis is that patients have different preferences and coping mechanisms when dealing with difficult news, and it is important to explore their wish to know about their health condition. Some patients may want to be fully informed about their diagnosis, prognosis, and treatment options, as they believe it empowers them to make decisions and take control of their healthcare. They may also value the opportunity to prepare emotionally and practically for the challenges that lie ahead. However, other patients may prefer to shield themselves from the potentially distressing information [5]. They may prioritize maintaining hope, protecting their mental well-being, or focusing on the present moment rather than dwelling on the future. Previous students showed that different cultures or religions influence how patients perceive the disease, their desire to know about the health condition, or their willingness to accept a diagnosis. For example, in some cultures, cancer is seen as a death sentence, leading to denial or avoidance of diagnosis and treatment [6]. There is a social stigma and gender label attached to cancer, which can lead to shame and embarrassment about the diagnosis [7-9]. Patients may be reluctant to seek medical attention, disclose their diagnosis, or follow through with treatment due to fear of being ostracized or discriminated against.

Remote communication methods like video and phone calls are being used more frequently to prevent the spread of the virus during disease outbreaks, such as the COVID-19 pandemic. It has become more difficult for healthcare professionals to inform patients about their cancer diagnosis. However, giving a cancer diagnosis over the phone can be a challenge since it does not allow for in-person support, and can come across as impersonal and insensitive. Unfortunately, in some cases, delivering bad news can have tragic conseq

打破坏消息是医疗保健专业人员的关键沟通能力。任何对危及生命的事件的披露,如恶性肿瘤诊断,往往会给患者带来巨大的压力。虽然一些患者可能会接受并决心与疾病作斗争,但研究一致表明,癌症患者通常会对自己的诊断结果做出一系列负面情绪的反应,如焦虑、痛苦和抑郁[1,2]。这些反应通常伴随着恐惧、不确定和对生活失去控制的感觉。患者也可能经历否认,表现为不愿接受或讨论诊断[3]。回避是另一种常见的反应,患者可能会选择避开某些使他们想起疾病的情况或人[4]。这些反应并不罕见,是对癌症诊断的压力和不确定性的自然反应。打破癌症诊断的一个常见的伦理困境是,患者在处理艰难的消息时有不同的偏好和应对机制,探索他们了解自己健康状况的愿望很重要。一些患者可能希望充分了解他们的诊断、预后和治疗方案,因为他们认为这使他们能够做出决定并控制自己的医疗保健。他们也可能重视为未来的挑战做好情感和实际准备的机会。然而,其他患者可能更愿意保护自己免受潜在的痛苦信息[5]。他们可能会优先考虑保持希望,保护他们的精神健康,或者关注现在而不是考虑未来。以前的学生表明,不同的文化或宗教会影响患者对疾病的看法,他们了解健康状况的愿望,或者他们接受诊断的意愿。例如,在某些文化中,癌症被视为死刑判决,导致拒绝或避免诊断和治疗[6]。癌症带有社会污名和性别标签,这可能导致对诊断的羞耻和尴尬[7-9]。由于害怕被排斥或歧视,患者可能不愿寻求医疗照顾、透露诊断或坚持治疗。在COVID-19大流行等疾病暴发期间,越来越多地使用视频和电话等远程通信方法来防止病毒传播。对于医疗保健专业人员来说,告知患者他们的癌症诊断结果变得越来越困难。然而,通过电话给出癌症诊断可能是一个挑战,因为它不允许面对面的支持,并且可能被认为是客观和麻木不仁的。不幸的是,在某些情况下,传递坏消息可能会带来悲剧性的后果。在新冠肺炎大流行期间,在香港隔离病房住院的一名老年患者在电话中被告知他患有恶性肿瘤,随后被塑料袋窒息而死。本文将研究一个现实生活中的自杀案例,病人通过电话被告知他们的癌症诊断,并讨论电信对打破坏消息的影响[10]。老年男性A先生于2022年因呼吸短促、胸部不适、双侧下肢水肿入院。进行了CT扫描,之后患者和他的妻子被告知疑似转移性肺癌的诊断。他后来在住院期间成为COVID-19的密切接触者,并被转移到隔离隔间。提供了一个装在塑料袋里的一次性便池。血液中肿瘤标志物的检测后来证实了他的癌症诊断,值班医生很快通过病房电话把这个坏消息告诉了病人。两天后,患者被发现昏迷不醒地躺在床上,头部被塑料袋包裹着。尽管进行了复苏,病人最终还是死了。在丧亲访谈中,患者家属回忆说,患者曾表示有疼痛和睡眠困难。案例涵盖了几个主题,包括医疗保健、患者护理、癌症诊断、COVID-19、隔离协议、与患者及其家属的沟通,以及在医疗保健环境中解决疼痛和睡眠问题的重要性。没有办法回顾性地知道,医生通过病房电话透露癌症诊断的选择是否导致了病人的自杀。尽管如此,在医院里通过电话透露坏消息是否合适还是值得讨论的。这一悲惨事件凸显了在住院期间对患者进行适当护理和沟通的重要性。 透露坏消息是医护人员的一项重要沟通能力。任何危及生命事件(如恶性肿瘤诊断)的披露都会给患者带来巨大压力。虽然有些患者可能会接受并决心与病魔抗争,但研究一致表明,癌症患者在得知诊断结果后往往会产生一系列负面情绪,如焦虑、痛苦和抑郁[1, 2]。这些反应往往伴随着恐惧、不确定感和对生活失去控制的感觉。患者还可能出现否认的情绪,表现为不愿接受或讨论诊断结果[3]。回避是另一种常见的反应,患者可能会选择回避某些会让他们联想到自己疾病的环境或人群[4]。这些反应并不罕见,是对癌症诊断的压力和不确定性的自然反应。打破癌症诊断的一个常见的伦理困境是,患者在处理困难消息时有不同的偏好和应对机制,因此探索他们了解自己健康状况的愿望非常重要。有些患者可能希望充分了解自己的诊断、预后和治疗方案,因为他们认为这能让他们做出决定并掌控自己的医疗保健。他们也会珍惜这个机会,为未来的挑战做好情感和实际的准备。然而,另一些患者可能更愿意回避这些可能令人痛苦的信息[5]。他们可能会优先考虑保持希望、保护自己的精神健康,或专注于当下而不是沉浸于未来。以往的研究表明,不同的文化或宗教会影响患者对疾病的看法、了解健康状况的愿望或接受诊断的意愿。例如,在某些文化中,癌症被视为死刑,导致否认或回避诊断和治疗[6]。癌症会被贴上社会污名和性别标签,从而导致患者对诊断感到羞耻和尴尬[7-9]。由于害怕受到排斥或歧视,患者可能不愿意就医、透露诊断结果或坚持治疗。在疾病爆发(如 COVID-19 大流行)期间,为了防止病毒传播,视频和电话等远程通信方式被更频繁地使用。医护人员向患者告知癌症诊断结果变得更加困难。然而,通过电话告知癌症诊断结果可能是一项挑战,因为它无法提供面对面的支持,而且可能显得不近人情和麻木不仁。不幸的是,在某些情况下,提供坏消息可能会带来悲剧性后果。其中一个例子发生在香港 COVID-19 大流行期间,一名住在隔离病房的老年患者在电话中被告知其恶性肿瘤诊断结果,随后使用塑料袋窒息而死。本文将研究一个真实的医院自杀案例,患者在通过电话被告知癌症诊断后自杀身亡,并讨论远程通信对打破坏消息的影响[10]。该案例涉及多个主题,包括医疗保健、患者护理、癌症诊断、COVID-19、隔离协议、与患者及其家属的沟通,以及在医疗保健环境中解决疼痛和睡眠问题的重要性。回想起来,我们无从得知医生选择通过病房电话透露癌症诊断结果是否导致了患者自杀。尽管如此,在医院环境中通过电话透露坏消息是否恰当仍值得讨论。这起悲剧事件凸显了在住院期间对病人进行适当护理和沟通的重要性。COVID-19 大流行表明,当出于感染控制的考虑,传统的面对面咨询变得不那么可取时,电话沟通可能是必要的。那么,我们应该如何调整,才能以感同身受的方式,巧妙地远程发布坏消息呢?在 COVID-19 时代,许多学者都参与了有关调整以改善远程坏消息沟通的讨论。Landa-Ramirez 等人提出了一个系统工具来帮助医疗服务提供者虚拟传递坏消息[27],而 Vitto 等人和 Gonçalves Júnior, Jucier 等人则提出了修改 SPIKES 协议的方法,以便在虚拟传递坏消息时更好地满足患者的需求[15, 28]。A 先生的癌症诊断是通过病房电话告知的。如果可能,智能手机或平板电脑等带有视频和音频的通讯设备比仅有音频的通讯设备更受欢迎[29]。 在典型的临床环境中,患者依靠医生提供个性化的信息,解释治疗方案,并帮助他们了解自己的情况,做出明智的决定。医生被期望传达令人不快的消息,但他们的角色不仅仅是在临床环境中透露诊断结果。伦理困境一直持续,直到病人表明他们希望获得多少关于他们医疗状况的信息的偏好。确定患者是否想要完全或部分了解情况,还是被蒙在鼓里,这一点至关重要。这种方法确保医生坚持伦理原则,如尊重病人的自主权和促进慈善。这一点尤其重要,因为最近的一项荟萃分析发现,在中国文化中,医生和护理人员通常不会向患者透露严重的医疗状况,如癌症,以保护他们的心理健康[11]。即使医生选择不透露诊断或预后,他们也应该遵循患者的意愿,坚持道
{"title":"In-patient suicide after telephone delivery of bad news to a suspected COVID-19 patient: What could be done to improve communication quality?","authors":"Natalie Tin Yau So,&nbsp;Olivia Miu Yung Ngan","doi":"10.1002/hcs2.74","DOIUrl":"10.1002/hcs2.74","url":null,"abstract":"<p>Breaking bad news is a critical communication competency for healthcare professionals. Any disclosure of a life-threatening event, such as a malignancy diagnosis, often causes significant stress to patients. While some patients may respond with acceptance and a determination to fight their illness, research has consistently shown that cancer patients often respond to the disclosure of their diagnosis with a range of negative emotions, such as anxiety, distress, and depression [<span>1, 2</span>]. These reactions are often accompanied by feelings of fear, uncertainty, and a sense of loss of control over their lives. Patients may also experience denial, manifesting as reluctance to accept or discuss the diagnosis [<span>3</span>]. Avoidance is another common reaction, where patients may choose to avoid certain situations or people that remind them of their illness [<span>4</span>]. These reactions are not uncommon and are a natural response to the stress and uncertainty of cancer diagnosis.</p><p>A common ethical dilemma in breaking a cancer diagnosis is that patients have different preferences and coping mechanisms when dealing with difficult news, and it is important to explore their wish to know about their health condition. Some patients may want to be fully informed about their diagnosis, prognosis, and treatment options, as they believe it empowers them to make decisions and take control of their healthcare. They may also value the opportunity to prepare emotionally and practically for the challenges that lie ahead. However, other patients may prefer to shield themselves from the potentially distressing information [<span>5</span>]. They may prioritize maintaining hope, protecting their mental well-being, or focusing on the present moment rather than dwelling on the future. Previous students showed that different cultures or religions influence how patients perceive the disease, their desire to know about the health condition, or their willingness to accept a diagnosis. For example, in some cultures, cancer is seen as a death sentence, leading to denial or avoidance of diagnosis and treatment [<span>6</span>]. There is a social stigma and gender label attached to cancer, which can lead to shame and embarrassment about the diagnosis [<span>7-9</span>]. Patients may be reluctant to seek medical attention, disclose their diagnosis, or follow through with treatment due to fear of being ostracized or discriminated against.</p><p>Remote communication methods like video and phone calls are being used more frequently to prevent the spread of the virus during disease outbreaks, such as the COVID-19 pandemic. It has become more difficult for healthcare professionals to inform patients about their cancer diagnosis. However, giving a cancer diagnosis over the phone can be a challenge since it does not allow for in-person support, and can come across as impersonal and insensitive. Unfortunately, in some cases, delivering bad news can have tragic conseq","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 6","pages":"400-405"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.74","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134902559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choices of medical institutions and associated factors in older patients with multimorbidity in stabilization period in China: A study based on logistic regression and decision tree model 中国多病老年患者在病情稳定期对医疗机构的选择及相关因素:基于逻辑回归和决策树模型的研究
Pub Date : 2023-10-16 DOI: 10.1002/hcs2.73
Xiaoran Wang, Dan Zhang

Background

As China's population ages, its disease spectrum is changing, and the coexistence of multiple chronic diseases has become the norm with respect to the health status of its elderly population. However, the health institution choices of older patients with multimorbidity in stabilization period remains underresearched. This study investigate the factors influencing the choices of older patients with multimorbidity to provide references for the rational allocation of healthcare resources.

Methods

A multistage, stratified, whole-group random-sampling method was used to select eligible older patients from September to December of 2022 who attended the Community Health Service Center of Guangdong Province. We adopted a self-designed questionnaire to collect patients' general, disease-related, social-support information, their intention to choose a healthcare provider. A binary logistic regression and decision tree model based on the Chi-squared automatic interaction detector algorithm were implemented to analyze the associated factors involved.

Results

A total of 998 patients in stabilization period were included in the study, of which 593 (59.42%) chose hospital and 405 (40.58%) chose primary care. Our binary logistic regression results revealed that age, sex, individual average annual income, educational level, self-reported health status, activities of daily living, alcohol consumption, family doctor contracting, and family supervision of medication or exercise were the principal factors influencing the choice of medical institutions for older patients with multimorbidity (p < 0.05). The decision-tree model reflected three levels and 11 nodes, and we screened a total of four influencing factors: activities of daily living, age, a family doctor contract, and patient sex. The data showed that the logistic regression model possessed an accuracy of 72.9% and that the decision tree model exhibited an accuracy of 68.7%. Prediction using the binary logistic regression was thus statistically superior to the categorical decision-tree model based on the Chi-squared automatic interaction detector algorithm (Z = 3.238, p = 0.001).

Conclusion

More than half of older patients with multimorbidity in stabilization period chose hospitals for healthcare. Efforts should be made to improve the quality of healthcare services and increase the medical contracting rate and recognition of family docto

背景 随着中国人口老龄化的加剧,疾病谱也在发生变化,多种慢性病并存已成为老年人群健康状况的常态。然而,对于患有多种疾病的老年患者在病情稳定期对医疗机构的选择研究仍然不足。本研究探讨影响多病老年患者选择医疗机构的因素,为合理分配医疗资源提供参考。 方法 采用多阶段、分层、整群随机抽样的方法,选取 2022 年 9 月至 12 月在广东省社区卫生服务中心就诊的符合条件的老年患者。采用自行设计的调查问卷,收集患者的一般信息、疾病相关信息、社会支持信息、选择医疗机构的意向等。采用二元逻辑回归和基于Chi-squared自动交互检测算法的决策树模型对相关因素进行分析。 结果 本研究共纳入了 998 名处于稳定期的患者,其中 593 人(59.42%)选择了医院,405 人(40.58%)选择了基层医疗机构。我们的二元逻辑回归结果显示,年龄、性别、个人平均年收入、教育程度、自我报告的健康状况、日常生活活动、饮酒量、家庭医生签约、家庭对用药或运动的监督是影响老年多发病患者选择医疗机构的主要因素(P <0.05)。决策树模型反映了三个层次和 11 个节点,我们共筛选出四个影响因素:日常生活活动、年龄、家庭医生签约和患者性别。数据显示,逻辑回归模型的准确率为 72.9%,决策树模型的准确率为 68.7%。因此,使用二元逻辑回归进行预测在统计学上优于基于Chi-squared自动交互检测算法的分类决策树模型(Z = 3.238,P = 0.001)。 结论 半数以上的多病老年患者在病情稳定期选择了医院就医。应努力提高医疗服务质量,提高医疗签约率和家庭医生的认可度,以吸引老年多发病患者到基层医疗机构就医。
{"title":"Choices of medical institutions and associated factors in older patients with multimorbidity in stabilization period in China: A study based on logistic regression and decision tree model","authors":"Xiaoran Wang,&nbsp;Dan Zhang","doi":"10.1002/hcs2.73","DOIUrl":"10.1002/hcs2.73","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As China's population ages, its disease spectrum is changing, and the coexistence of multiple chronic diseases has become the norm with respect to the health status of its elderly population. However, the health institution choices of older patients with multimorbidity in stabilization period remains underresearched. This study investigate the factors influencing the choices of older patients with multimorbidity to provide references for the rational allocation of healthcare resources.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multistage, stratified, whole-group random-sampling method was used to select eligible older patients from September to December of 2022 who attended the Community Health Service Center of Guangdong Province. We adopted a self-designed questionnaire to collect patients' general, disease-related, social-support information, their intention to choose a healthcare provider. A binary logistic regression and decision tree model based on the Chi-squared automatic interaction detector algorithm were implemented to analyze the associated factors involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 998 patients in stabilization period were included in the study, of which 593 (59.42%) chose hospital and 405 (40.58%) chose primary care. Our binary logistic regression results revealed that age, sex, individual average annual income, educational level, self-reported health status, activities of daily living, alcohol consumption, family doctor contracting, and family supervision of medication or exercise were the principal factors influencing the choice of medical institutions for older patients with multimorbidity (<i>p</i> &lt; 0.05). The decision-tree model reflected three levels and 11 nodes, and we screened a total of four influencing factors: activities of daily living, age, a family doctor contract, and patient sex. The data showed that the logistic regression model possessed an accuracy of 72.9% and that the decision tree model exhibited an accuracy of 68.7%. Prediction using the binary logistic regression was thus statistically superior to the categorical decision-tree model based on the Chi-squared automatic interaction detector algorithm (<i>Z</i> = 3.238, <i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>More than half of older patients with multimorbidity in stabilization period chose hospitals for healthcare. Efforts should be made to improve the quality of healthcare services and increase the medical contracting rate and recognition of family docto","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 6","pages":"359-369"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136079032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTED: Artificial intelligence for emergency medical care 撤下:用于紧急医疗护理的人工智能
IF 3.3 Pub Date : 2023-10-13 DOI: 10.1002/hcs2.72
Shivam Rajput, Pramod Kumar Sharma, Rishabha Malviya

There is increasing research into the potential benefits of incorporating artificial intelligence (AI) and machine learning algorithms into emergency medical services. AI is finding new applications across a wide range of sectors, one of which is healthcare, where it is being used to enhance clinical diagnostics. AI solutions have enormous untapped potential to improve healthcare efficiency and quality, thus researchers have focused heavily on emergency medicine (EM). Many individuals without prior experience with any physician often receive their initial medical care in the emergency room. Two areas that could benefit from the implementation of AI are reducing waiting times and enhancing diagnostic capabilities. This study provides further explanation of how AI is used in emergency rooms. Several machine learning-based algorithms are also addressed. In this research, we summarise recent developments in the use of AI in EM. This research tries to summarise the usefulness of AI in EM by looking at recent developments in emergency department operations and clinical patient management.

越来越多的研究表明,将人工智能(AI)和机器学习算法纳入紧急医疗服务的潜在好处。人工智能正在广泛的领域寻找新的应用,其中之一是医疗保健,它被用于增强临床诊断。人工智能解决方案在提高医疗效率和质量方面具有巨大的未开发潜力,因此研究人员将重点放在急诊医学(EM)上。许多没有任何医生经验的人通常在急诊室接受他们最初的医疗护理。人工智能的实施可以使两个领域受益:减少等待时间和增强诊断能力。这项研究进一步解释了人工智能如何在急诊室中使用。还讨论了几种基于机器学习的算法。在本研究中,我们总结了人工智能在EM中使用的最新进展。本研究试图通过查看急诊科手术和临床患者管理的最新进展来总结人工智能在EM中的有用性。
{"title":"RETRACTED: Artificial intelligence for emergency medical care","authors":"Shivam Rajput,&nbsp;Pramod Kumar Sharma,&nbsp;Rishabha Malviya","doi":"10.1002/hcs2.72","DOIUrl":"10.1002/hcs2.72","url":null,"abstract":"<p>There is increasing research into the potential benefits of incorporating artificial intelligence (AI) and machine learning algorithms into emergency medical services. AI is finding new applications across a wide range of sectors, one of which is healthcare, where it is being used to enhance clinical diagnostics. AI solutions have enormous untapped potential to improve healthcare efficiency and quality, thus researchers have focused heavily on emergency medicine (EM). Many individuals without prior experience with any physician often receive their initial medical care in the emergency room. Two areas that could benefit from the implementation of AI are reducing waiting times and enhancing diagnostic capabilities. This study provides further explanation of how AI is used in emergency rooms. Several machine learning-based algorithms are also addressed. In this research, we summarise recent developments in the use of AI in EM. This research tries to summarise the usefulness of AI in EM by looking at recent developments in emergency department operations and clinical patient management.</p>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"4 5","pages":"359-374"},"PeriodicalIF":3.3,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.72","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135917876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of older population on public health spending: Evidence from Spain 老年人口对公共卫生支出的影响:来自西班牙的证据
Pub Date : 2023-10-12 DOI: 10.1002/hcs2.68
Carlos Navarro-García, Antonio Sarria-Santamera

Background

The gradual ageing of the population, and its effect on public spending, constitutes an urgent challenge for advanced economies. Through this study, we analyse the effect of older people, and their health and individual characteristics, on public health spending.

Methods

Using logistic regression methods, we have analysed the use of different health services and health technologies by older people in Spain, controlled for several health, socioeconomic, and other individual factors.

Results

The main factors that explain the consumption of both health services and health technology, above age, are related to the so-called need factors: self-reported health status, presence of chronic diseases, and disability.

Conclusion

Knowing the main factors that imply greater public health spending is a topic of special interest for designing efficient health policies, in a context of growth in public health spending. In this way, preventive attention on the so-called need factors may be an important driver to improve the effectiveness of spending.

背景人口的逐渐老龄化及其对公共支出的影响,是发达经济体面临的紧迫挑战。通过这项研究,我们分析了老年人及其健康和个人特征对公共卫生支出的影响。方法采用逻辑回归方法,我们分析了西班牙老年人对不同卫生服务和卫生技术的使用情况,并考虑了几个健康、社会经济和其他个人因素。结果解释年龄以上的医疗服务和医疗技术消费的主要因素与所谓的需求因素有关:自我报告的健康状况、是否患有慢性病和残疾。结论在公共卫生支出增长的背景下,了解意味着增加公共卫生支出的主要因素是设计有效卫生政策的一个特别感兴趣的话题。这样,对所谓需求因素的预防性关注可能是提高支出有效性的重要驱动因素。
{"title":"The effect of older population on public health spending: Evidence from Spain","authors":"Carlos Navarro-García,&nbsp;Antonio Sarria-Santamera","doi":"10.1002/hcs2.68","DOIUrl":"https://doi.org/10.1002/hcs2.68","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The gradual ageing of the population, and its effect on public spending, constitutes an urgent challenge for advanced economies. Through this study, we analyse the effect of older people, and their health and individual characteristics, on public health spending.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using logistic regression methods, we have analysed the use of different health services and health technologies by older people in Spain, controlled for several health, socioeconomic, and other individual factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The main factors that explain the consumption of both health services and health technology, above age, are related to the so-called need factors: self-reported health status, presence of chronic diseases, and disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Knowing the main factors that imply greater public health spending is a topic of special interest for designing efficient health policies, in a context of growth in public health spending. In this way, preventive attention on the so-called need factors may be an important driver to improve the effectiveness of spending.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 5","pages":"306-316"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.68","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68179325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical and policy considerations for organ trafficking and transplant tourism: Based on the UK's first international case of human trafficking for the purpose of organ removal 器官贩运和移植旅游的伦理和政策考虑:基于英国首例以器官切除为目的的人口贩运国际案件
Pub Date : 2023-10-10 DOI: 10.1002/hcs2.70
Lanyi Yu, Xiaomei Zhai

This study examines the UK's May 2023 judgment in an international organ trafficking and organ tourism case. Human trafficking for organ removal is one of the least understood but growing forms of trafficking worldwide. Countries in the Middle East, Asia, and the Americas are often widely criticized by the international transplant community as sites for organ trafficking. However, we believe that when discussing this issue, it is not just these areas that need to be addressed. What is particularly special is that this case not only involves transnational human trafficking, organ trafficking, and illegal organ transplantation interest chains but also involves the participation of national political officials and complex social and humanistic factors. This article focuses on the current ethical and policy issues involved in organ transplant tourism and organ trafficking and analyzes the implications of this case for our country's donation and transplantation work.

这项研究考察了英国2023年5月对一起国际器官贩运和器官旅游案的判决。为切除器官而贩运人口是世界范围内最不为人所知但日益增多的贩运形式之一。中东、亚洲和美洲国家经常被国际移植界广泛批评为器官贩运场所。然而,我们认为,在讨论这个问题时,需要处理的不仅仅是这些领域。特别的是,本案不仅涉及跨国人口贩运、器官贩运和非法器官移植利益链,还涉及国家政治官员的参与和复杂的社会人文因素。本文关注当前器官移植旅游和器官贩运中涉及的伦理和政策问题,并分析该案件对我国捐赠和移植工作的影响。
{"title":"Ethical and policy considerations for organ trafficking and transplant tourism: Based on the UK's first international case of human trafficking for the purpose of organ removal","authors":"Lanyi Yu,&nbsp;Xiaomei Zhai","doi":"10.1002/hcs2.70","DOIUrl":"https://doi.org/10.1002/hcs2.70","url":null,"abstract":"<p>This study examines the UK's May 2023 judgment in an international organ trafficking and organ tourism case. Human trafficking for organ removal is one of the least understood but growing forms of trafficking worldwide. Countries in the Middle East, Asia, and the Americas are often widely criticized by the international transplant community as sites for organ trafficking. However, we believe that when discussing this issue, it is not just these areas that need to be addressed. What is particularly special is that this case not only involves transnational human trafficking, organ trafficking, and illegal organ transplantation interest chains but also involves the participation of national political officials and complex social and humanistic factors. This article focuses on the current ethical and policy issues involved in organ transplant tourism and organ trafficking and analyzes the implications of this case for our country's donation and transplantation work.</p>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 5","pages":"339-344"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.70","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68179865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development trends of etiological research contents and methods of noncommunicable diseases 非传染性疾病病原学研究内容和方法的发展趋势
Pub Date : 2023-10-09 DOI: 10.1002/hcs2.69
Dafang Chen, Yujia Ma, Han Xiao, Zeyu Yan

Noncommunicable diseases (NCDs) are a significant public concern, greatly impacting the economic and social development in China. In 2019, NCDs accounted for a staggering 88.5% of total deaths in China, with cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes—the four major chronic diseases—contributing to a premature mortality rate of 16.5% [1]. The complexity of NCDs arises from the involvement of multiple genetic and environmental factors that interact in intricate ways. The complexity is characterized by a multitude of interactions among genes, proteins, and metabolic pathways throughout the various stages of life. Furthermore, these interactions demonstrate time-dependent specificity during the different phases of the life course. Prior research on the etiology of NCDs tended to focus on “specificity,” which overlooked the concept of “universality.” Studies are often conducted from one risk factor, one disease, or one dimension, leading to an insufficient understanding of NCD etiology and less than satisfactory outcomes in prevention and control efforts. Therefore, the aim of this review is to highlight and propose a new trend in NCD etiology research, considering the research focus and research methodology.

The relationships among NCDs are intricate, and patients often show distinct patterns of multiple diseases, reflecting population heterogeneity in comorbidity. The study of comorbidity patterns among populations affected by NCDs can offer valuable insights for developing effective prevention and management strategies. In a retrospective study by Jansana et al. [2] using electronic health records, five multimorbidity clusters were identified among breast cancer survivors in Spain; notably, the “musculoskeletal and cardiovascular disease” pattern showed a significantly higher risk of mortality than other NCDs. Advancements in computational science contribute to the emergence of network analysis based on graph theory as a powerful tool for understanding the complexity of comorbidity from a holistic and systemic perspective. Graph theory in network analysis facilitates the construction of comorbidity networks in which disease status is represented as nodes and risk associations are shown as edges, thereby visualizing the co-occurrence of diseases in a concise and intuitive manner. Such topological approaches enable the prioritization of disease severity and identification of the core disease within a comorbidity network. Furthermore, network clustering techniques have been applied to identify specific comorbidity patterns in NCDs. However, cautiousness in interpreting the identified patterns is essential because some network topology indexes may lack practical significance. The challenge in interpreting the identified patterns can be addressed by considering association rules. Typically, association rule mining is used to identify comorbidity patterns, and network analysis is used to

非传染性疾病(NCDs)是公众关注的一个重要问题,极大地影响了中国的经济和社会发展。2019年,非传染性疾病占中国总死亡人数的88.5%,心血管疾病、癌症、慢性呼吸道疾病和糖尿病这四种主要慢性病的过早死亡率高达16.5%[1]。非传染性疾病的复杂性源于多种遗传和环境因素的参与,这些因素以复杂的方式相互作用。这种复杂性的特点是在生命的各个阶段,基因、蛋白质和代谢途径之间存在大量的相互作用。此外,在生命过程的不同阶段,这些相互作用表现出与时间相关的特异性。先前对非传染性疾病病因的研究往往侧重于“特异性”,而忽略了“普遍性”的概念。研究往往从一个风险因素、一种疾病或一个维度进行,导致对非传染性病毒病因的理解不足,预防和控制工作的结果也不令人满意。因此,本综述的目的是在考虑研究重点和研究方法的基础上,突出并提出非传染性疾病病因研究的新趋势。非传染性疾病之间的关系是复杂的,患者往往表现出多种疾病的不同模式,反映出共病的人群异质性。对非传染性疾病患者共病模式的研究可以为制定有效的预防和管理策略提供有价值的见解。在Jansana等人[2]使用电子健康记录进行的回顾性研究中,在西班牙的癌症幸存者中确定了五个多发病集群;值得注意的是,“肌肉骨骼和心血管疾病”模式的死亡率明显高于其他非传染性疾病。计算科学的进步有助于基于图论的网络分析的出现,它是从整体和系统的角度理解共病复杂性的有力工具。网络分析中的图论有助于构建共病网络,其中疾病状态表示为节点,风险关联表示为边缘,从而以简洁直观的方式可视化疾病的共现。这种拓扑方法能够在共病网络中确定疾病严重程度的优先级和核心疾病的识别。此外,网络聚类技术已被应用于识别非传染性疾病的特定共病模式。然而,谨慎地解释识别的模式是至关重要的,因为一些网络拓扑索引可能缺乏实际意义。解释已识别模式的挑战可以通过考虑关联规则来解决。通常,关联规则挖掘用于识别共病模式,网络分析用于可视化和确定共病网络中的核心疾病。例如,Hernández等人[3]使用关联规则在爱尔兰成年人中发现了几种共病模式,随后通过网络分析发现,高胆固醇、高血压和关节炎与其他疾病的关联次数最多,将其列为共病网络中的核心疾病。非传染性疾病的发展是一个漫长而渐进的过程,其特点是风险随着时间的推移而积累。疾病进展过程中的复杂变化意味着患者可能有不同的轨迹,导致相同的疾病模式。至关重要的是要考虑每种疾病成分进展的时间特征,即使是在特定的共病模式中。在人群层面识别疾病轨迹对于预防特定非传染性疾病人群的共病至关重要,并为了解共病病因提供了重要的流行病学证据,使共病轨迹研究成为当前的研究热点。Jensen等人[4]利用覆盖丹麦全体人口的电子健康登记处的数据,对暂时性疾病进展模式进行了发现驱动的分析。他们确定了1171个重要的轨迹,并将其分组为以关键诊断为中心的模式,如慢性阻塞性肺病和痛风,这对疾病进展和早期诊断至关重要,以减轻不良后果。普通人群的共病轨迹研究在研究设计、数据分析和结果解释方面提出了挑战,因此此类研究通常在患有特定疾病的人群中进行,从而简化了设计、数据解析和结果解释。例如,Jeong等人[5]在嵌套的病例对照研究设计中,使用全人群的索赔数据调查了2型糖尿病。 在反式组学分析中,一组生物分子或表型被视为单一变量,整合为信息层,形成多级结构数据库。这种方法能够客观全面地重建连接人类基因组、暴露体和人体内现象的复杂网络。鉴于网络的复杂性,生物网络模型已成为首选[16]。这种模型放弃了从单个分子或组学水平研究疾病病因的单一视角,而是使用生物信息学和计算技术来发现分子之间的相互作用,从而在不同类型的生物数据层之间建立高维的内部联系。这种方法导致了复杂分子信息网络的形成,并符合系统生物学的原理[17]。因此,基于跨组学数据识别致病途径和构建致病网络对于揭示非传染性疾病的根本原因变得不可或缺[16,18,19]。Bodein等人[20]充分利用转录组学、蛋白质组学和代谢组学的纵向数据构建单个组学网络,然后通过随机游动使用网络传播在多个组学层之间建立调控网络。通过识别单组学分析无法捕捉到的组间相互作用,他们发现了两个核心的动态生物学集群,它们将糖尿病的病因网络与肾小管酸中毒和不宁腿综合征联系起来。这一突破性发现为糖尿病发病和进展的潜在机制和相互作用提供了新的见解。网络比较对于获得致病网络和途径的统计证据至关重要。网络比较有两种典型的分析策略。(1) 假设驱动策略,需要全面了解感兴趣疾病的生理、生化和病理机制。基于先前细胞实验、动物研究或组学分析的先验理解,提前概述了合理的假设致病网络/途径。随后,在人群水平上检查组间差异和网络/通路节点的影响,以评估基于初始假设的致病网络/通路在人群中的有效性和实用性。(2) 数据驱动策略,在没有任何预定义假设的情况下,在人群水平上获得高通量组学标记。系统生物学方法用于构建一个连接暴露因素、生物标志物和疾病终点的网络。在人群水平上评估网络/途径的组间差异和效果,并用于为进一步的实验验证、药物靶点识别和预防或治疗措施的制定提供基础[21]。Ji等人[22]提出了一种强大的基于分数的统计测试(NetDifM)来测量加权生物网络中的群体差异。他们成功地捕捉到了卵巢癌症患者和健康对照者之间基因表达网络的差异,并确定了致病性PI3K-AKT信号通路、Notch信号通路及其下游子网络。在非传染性疾病的病因研究中,复杂生物系统的动态属性共同要求时间性和高维性,这表明需要研究疾病发生和发展的整个生命过程的代谢特征。目前,非传染性疾病的研究主要集中在成年人身上;例如,对28-74岁人群的Framingham研究[23],对37-85岁人群的英国生物库研究[24],以及对30-79岁人群的中国慢性病前瞻性研究[25]。然而,健康与疾病的发育起源理论提出,母亲在怀孕期间的营养和环境暴露可能会影响后代成年后患非传染性疾病的风险[26,27]。该提案建议,非传染性疾病的病因研究应从主要关注成年人的特定阶段视角过渡到包括妊娠、儿童、青少年、青年、中年和老年在内的生命历程方法,以确定与非传染性疾病发展和整个生命期其他健康结果相关的风险因素,称为生命过程流行病学[28]。生命过程流行病学主要由风险累积模型和关键时期模型组成。风险累积模型假设环境暴露、社会经济地位和行为因素等风险因素独立或协同对健康产生长期影响。 因此,该模型侧重于暴露的积累和聚集,因为疾病不仅与个人暴露有关,还与家庭暴露和社会经济地位有关[28,29]。关键时期模型强调,关键发育时期的生物编程可能会受到后期生理或心理压力的影响[28,29]。轨迹分析是生命历程流行病学中常用的纵向数据处理方法。轨迹分析方法用于通过重复的纵向测量将生长轨迹与个体暴露数据拟合,识别群体中具有潜在不同生长轨迹的亚组,集体和单独描述暴露因子生长曲线的趋势,通过分析生长曲线参数,探讨暴露对疾病发生和发展的累积影响和临界/敏感期[30,31]。传统的轨迹分析方法包括基于Z分数的增长曲线拟合、多级建模、基于组的轨迹建模和潜在类别混合效应模型[32,33]。张等人[34]进行了生命历程轨迹分析和中介分析,以量化儿童至成年肥胖的生命历程累积负担,并表明肥胖对心血管健康的不利影响始于儿童时期,并在整
{"title":"Development trends of etiological research contents and methods of noncommunicable diseases","authors":"Dafang Chen,&nbsp;Yujia Ma,&nbsp;Han Xiao,&nbsp;Zeyu Yan","doi":"10.1002/hcs2.69","DOIUrl":"https://doi.org/10.1002/hcs2.69","url":null,"abstract":"<p>Noncommunicable diseases (NCDs) are a significant public concern, greatly impacting the economic and social development in China. In 2019, NCDs accounted for a staggering 88.5% of total deaths in China, with cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes—the four major chronic diseases—contributing to a premature mortality rate of 16.5% [<span>1</span>]. The complexity of NCDs arises from the involvement of multiple genetic and environmental factors that interact in intricate ways. The complexity is characterized by a multitude of interactions among genes, proteins, and metabolic pathways throughout the various stages of life. Furthermore, these interactions demonstrate time-dependent specificity during the different phases of the life course. Prior research on the etiology of NCDs tended to focus on “specificity,” which overlooked the concept of “universality.” Studies are often conducted from one risk factor, one disease, or one dimension, leading to an insufficient understanding of NCD etiology and less than satisfactory outcomes in prevention and control efforts. Therefore, the aim of this review is to highlight and propose a new trend in NCD etiology research, considering the research focus and research methodology.</p><p>The relationships among NCDs are intricate, and patients often show distinct patterns of multiple diseases, reflecting population heterogeneity in comorbidity. The study of comorbidity patterns among populations affected by NCDs can offer valuable insights for developing effective prevention and management strategies. In a retrospective study by Jansana et al. [<span>2</span>] using electronic health records, five multimorbidity clusters were identified among breast cancer survivors in Spain; notably, the “musculoskeletal and cardiovascular disease” pattern showed a significantly higher risk of mortality than other NCDs. Advancements in computational science contribute to the emergence of network analysis based on graph theory as a powerful tool for understanding the complexity of comorbidity from a holistic and systemic perspective. Graph theory in network analysis facilitates the construction of comorbidity networks in which disease status is represented as nodes and risk associations are shown as edges, thereby visualizing the co-occurrence of diseases in a concise and intuitive manner. Such topological approaches enable the prioritization of disease severity and identification of the core disease within a comorbidity network. Furthermore, network clustering techniques have been applied to identify specific comorbidity patterns in NCDs. However, cautiousness in interpreting the identified patterns is essential because some network topology indexes may lack practical significance. The challenge in interpreting the identified patterns can be addressed by considering association rules. Typically, association rule mining is used to identify comorbidity patterns, and network analysis is used to","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 5","pages":"352-357"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.69","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inception of the Indian Digital Health Mission: Connecting…the…Dots 印度数字健康使命的开端:连接…点
Pub Date : 2023-10-09 DOI: 10.1002/hcs2.67
Gerard Marshall Raj, Sathian Dananjayan, Neeraj Agarwal

The purpose of the National Digital Health Mission (or more precisely, the Ayushman Bharat Digital Mission) is to promote and facilitate the evolution of the National Digital Health Ecosystem in India. The Health Facility Registry, the Healthcare Professionals Registry, and the Unified Health Interface are the major components of the proposed system—which is intended to be a co-operative federated architecture with optimal interoperability provision coupled with authorized access.

国家数字健康使命(或者更准确地说,阿尤什曼·巴拉特数字使命)的目的是促进和促进印度国家数字健康生态系统的发展。卫生设施注册处、医疗保健专业人员注册处和统一健康接口是拟议系统的主要组成部分,该系统旨在成为一个合作的联邦架构,具有最佳的互操作性和授权访问。
{"title":"Inception of the Indian Digital Health Mission: Connecting…the…Dots","authors":"Gerard Marshall Raj,&nbsp;Sathian Dananjayan,&nbsp;Neeraj Agarwal","doi":"10.1002/hcs2.67","DOIUrl":"https://doi.org/10.1002/hcs2.67","url":null,"abstract":"<p>The purpose of the National Digital Health Mission (or more precisely, the Ayushman Bharat Digital Mission) is to promote and facilitate the evolution of the National Digital Health Ecosystem in India. The Health Facility Registry, the Healthcare Professionals Registry, and the Unified Health Interface are the major components of the proposed system—which is intended to be a co-operative federated architecture with optimal interoperability provision coupled with authorized access.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 5","pages":"345-351"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.67","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
China's aging population: A review of living arrangement, intergenerational support, and wellbeing 中国人口老龄化:生活安排、代际支持和幸福感综述
Pub Date : 2023-10-09 DOI: 10.1002/hcs2.64
Litao Zhao

China's rapid population aging and remarkable family-level changes have raised concerns about the weakening of its family-based elderly care. The last decade indeed has seen a clear departure from multigenerational living to alternative living arrangements such as living with spouse only and solo living. However, ample evidence suggests that Chinese families have demonstrated considerable resilience amidst profound sociodemographic changes. This review article highlights the importance of government–society cooperation in meeting the social challenges of population aging. A key factor is the persistient filial piety norms, which enable children living far or close, migrant or nonmigrant, to rearrange financial, instrumental, and emotional support to aging parents. Equally important is the step-in of the government to share elderly care responsibilities, provide support through deepening pension and healthcare reforms, and implement the active and healthy aging agenda. How the two factors play out over the next decade and beyond will have profound implications on the living arrangement, intergenerational support, and wellbeing of older adults in China.

中国快速的人口老龄化和显著的家庭水平变化引发了人们对家庭养老弱化的担忧。在过去的十年里,确实看到了从多代人生活到替代生活安排的明显转变,如只与配偶生活和独自生活。然而,充分的证据表明,中国家庭在深刻的社会人口结构变化中表现出了相当大的韧性。这篇综述文章强调了政府与社会合作在应对人口老龄化的社会挑战方面的重要性。一个关键因素是持续的孝道规范,它使居住在远方或附近、移民或非移民的孩子能够重新安排对年迈父母的经济、工具和情感支持。同样重要的是,政府介入分担养老责任,通过深化养老金和医疗改革提供支持,并实施积极健康的老龄化议程。这两个因素在未来十年及以后的发展将对中国老年人的生活安排、代际支持和福祉产生深远影响。
{"title":"China's aging population: A review of living arrangement, intergenerational support, and wellbeing","authors":"Litao Zhao","doi":"10.1002/hcs2.64","DOIUrl":"https://doi.org/10.1002/hcs2.64","url":null,"abstract":"<p>China's rapid population aging and remarkable family-level changes have raised concerns about the weakening of its family-based elderly care. The last decade indeed has seen a clear departure from multigenerational living to alternative living arrangements such as living with spouse only and solo living. However, ample evidence suggests that Chinese families have demonstrated considerable resilience amidst profound sociodemographic changes. This review article highlights the importance of government–society cooperation in meeting the social challenges of population aging. A key factor is the persistient filial piety norms, which enable children living far or close, migrant or nonmigrant, to rearrange financial, instrumental, and emotional support to aging parents. Equally important is the step-in of the government to share elderly care responsibilities, provide support through deepening pension and healthcare reforms, and implement the active and healthy aging agenda. How the two factors play out over the next decade and beyond will have profound implications on the living arrangement, intergenerational support, and wellbeing of older adults in China.</p>","PeriodicalId":100601,"journal":{"name":"Health Care Science","volume":"2 5","pages":"317-327"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hcs2.64","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Health Care Science
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1