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CFD modeling of reactive species air cleaner applications in a classroom 反应物空气净化器在教室中应用的 CFD 建模
Pub Date : 2024-09-10 DOI: 10.1016/j.indenv.2024.100046
Youngbo Won , William Bahnfleth , John Cimbala

Due to increasing concerns related to airborne virus spread indoors, more reactive species air cleaners are being utilized in classrooms. Reactive species generated by air cleaners decompose airborne pathogens chemically, decreasing the risk of infection. Due to the high reactivity of these oxidants, reactive species may be distributed nonuniformly in indoor environments, as are viral aerosols emitted by infectors. Heterogeneous distributions of reactive species may cause spatially non-uniform removal rates of viral aerosols. However, there is little information regarding spatial distributions of either reactive species or viral aerosols in ventilated classrooms. Thus, the objective of this study was to investigate spatial distributions of reactive species and infectious aerosols and to examine how operating conditions of air cleaners affect viral aerosol removal rates. A CFD model simulated the operation of a reactive species air cleaner generating hydrogen peroxide (H2O2) in a mechanically ventilated 237 m3 classroom with nine occupants. The reactive species air cleaner showed a 3–20 times higher equivalent air change rate to a HEPA filter air cleaner with the same inlet and outlet flows. During the operation of reactive species air cleaners, elevated viral aerosol concentration was confined to regions near infectors. This was due to the high reactivity of reactive species, decreasing the infection probability of receptors from 3.2 % to 0.1 % with a 1-hour exposure time. As the room average concentration of reactive species increased from 15.6 to 50.4 ppb, both below the US Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (PEL) of 1000 ppb, the room average infection probability decreased from 0.3 % to 0.1 %. Due to the residence times of reactive species, the location of reactive species air cleaners affected the inactivation rate of viral aerosol, resulting in a 24 % variation of concentration difference of infectious aerosol with air cleaner locations.

由于人们越来越担心空气中的病毒会在室内传播,教室里正在使用更多的活性物质空气净化器。空气净化器产生的活性物质会对空气中的病原体进行化学分解,从而降低感染风险。由于这些氧化剂的高反应性,反应物在室内环境中的分布可能不均匀,就像感染者散发的病毒气溶胶一样。活性物质的不均匀分布可能会导致病毒气溶胶的去除率在空间上不均匀。然而,有关通风教室中活性物质或病毒气溶胶空间分布的信息很少。因此,本研究的目的是调查活性物质和传染性气溶胶的空间分布,并研究空气净化器的运行条件如何影响病毒气溶胶的去除率。CFD 模型模拟了在一间机械通风的 237 立方米教室中,一台产生过氧化氢(H2O2)的活性物质空气净化器的运行情况。在进出口流量相同的情况下,活性物质空气净化器的等效换气率是高效空气过滤器空气净化器的 3-20 倍。在反应型空气净化器运行期间,病毒气溶胶浓度升高的区域仅限于感染者附近。这是由于活性物质的高反应性,在 1 小时的暴露时间内,受体的感染概率从 3.2% 降至 0.1%。随着室内活性物质的平均浓度从 15.6 ppb 增加到 50.4 ppb(均低于美国职业安全与健康管理局(OSHA)规定的 1000 ppb 的允许接触限值),室内平均感染概率从 0.3 % 下降到 0.1 %。由于活性物质的停留时间,活性物质空气净化器的位置会影响病毒气溶胶的灭活率,导致感染性气溶胶的浓度差异随空气净化器位置的不同而变化 24%。
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引用次数: 0
Prediction of air quality perception in aircraft cabin based on psychophysical model and artificial neural network (ANN)-based model 基于心理物理模型和人工神经网络(ANN)模型的飞机客舱空气质量感知预测
Pub Date : 2024-09-06 DOI: 10.1016/j.indenv.2024.100044
Yihui Yin , Lei Zhao , Ruoyu You , Jingjing Pei , Hanyu Li , Junzhou He , Yuexia Sun , Xudong Yang , Qingyan Chen

As people are the ultimate arbiters of air quality in built environments, perceived air quality (PAQ) is receiving increasing attention. Odor is often designated as the main target of PAQ regulation, but due to the complex mechanism of cross-modal human perception under multi-pollutant coupling, the accuracy of odor perception evaluation and prediction in the real environment is limited. This study obtained passengers’ evaluation of their perception of cabin air quality (CAQ) and odor intensity (OI) in commercial aircraft cabins through on-board measurement of 36 flights and 878 supporting questionnaires. Although the CAQ was generally acceptable, 25 % of passengers were not satisfied, and odor complaints (OI ≥ 3) were captured on 6 flights. The odor concentration (OC) and OI in the aircraft cabin were calculated based on the olfactory threshold and the Weber-Fechner psychophysical model, and the total OC distribution in different flight phases ranged from 28.4 to 66.1. Aldehydes (especially long-chain) were most likely to be smelled directly. Limited by the two basic assumptions that VOC interaction was non-existent and that the odor intensity was only related to VOC, the accuracy of OI calculated by the existing model was about 0.4. In order to improve the accuracy of evaluation, a new data-driven model for human perception (CAQ and OI) prediction based on a knowledge-based BP neural network was proposed, and its prediction accuracy (R2: 0.81–0.87) and generalization (R2: 0.76–0.93) were verified. The new model is able to consider the interactions among individual differences, environmental factors and VOC concentrations, thus providing a method innovation for realizing people-oriented VOC control.

人们是建筑环境中空气质量的最终决定者,因此感知空气质量(PAQ)越来越受到人们的关注。气味通常被指定为 PAQ 的主要调节对象,但由于多污染物耦合下人类跨模态感知的复杂机制,真实环境中气味感知评估和预测的准确性有限。本研究通过对 36 个航班的机上测量和 878 份辅助问卷调查,获得了乘客对商用飞机客舱空气质量(CAQ)和气味强度(OI)的感知评价。尽管客舱空气质量总体上可以接受,但仍有 25% 的乘客不满意,有 6 个航班上出现了异味投诉(OI ≥ 3)。根据嗅觉阈值和韦伯-费希纳心理物理模型计算了机舱内的气味浓度(OC)和 OI,不同飞行阶段的总 OC 分布范围为 28.4 至 66.1。醛类(尤其是长链)最有可能被直接闻到。受限于不存在挥发性有机化合物相互作用和气味强度仅与挥发性有机化合物有关这两个基本假设,现有模型计算的 OI 精确度约为 0.4。为了提高评估的准确性,提出了一种基于知识的 BP 神经网络的新的数据驱动型人类感知(CAQ 和 OI)预测模型,并验证了其预测准确性(R2:0.81-0.87)和泛化性(R2:0.76-0.93)。新模型能够考虑个体差异、环境因素和挥发性有机化合物浓度之间的相互作用,从而为实现以人为本的挥发性有机化合物控制提供了方法创新。
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引用次数: 0
What sizes of droplets contribute to long-range airborne transmission? 什么大小的液滴会造成远距离空气传播?
Pub Date : 2024-09-06 DOI: 10.1016/j.indenv.2024.100045
Pan Cheng , Wei Jia , Li Liu , Hui-Ling Yen , Yuguo Li

The size range of respiratory droplets contributing to long-range airborne transmission of infections determines the targeted intervention methods. However, the exact size range remains unknown, and the influencing parameters are also undetermined. Here, we investigated the size-resolved transport and fate of respiratory droplets in four reported venues of COVID-19 outbreaks. We utilised a transient number balance model, a set of expired droplet size distributions, existing formulas for size-resolved settling rates and filtration efficiencies, and a deposition model from the International Commission on Radiological Protection. This enabled us to obtain the size-resolved concentrations of exhaled droplets in indoor air, the size-resolved number of droplet nuclei in the inhaled air, and the number of droplets deposited throughout the respiratory tract. The newly defined airborne transmission size range of expired droplets depends on the effective dilution flow rate of the infection venue under consideration. Three criteria were proposed for determining the sizes of droplets involved in long-range airborne transmission. The airborne transmission droplets typically featured an initial diameter of 0.1–4–6 µm, with an hourly volume generation rate of 0.38–0.42 nL/h per index case in the four venues. This newly estimated volume of airborne transmission droplets provides an essential input into the viral load method for estimating the infectious quanta generation rate.

Practical significance

Our size-resolved estimation reveals that only a tiny fraction of expired infectious droplets within an airborne transmission size range survives after the removal effects of ventilation, settling, deactivation, and filtration, as well as the transient dilution effect. These droplets remain in indoor air, potentially contributing to long-range airborne transmission. The airborne transmission size range depends on the size-dependent dilution capacity of a room.

造成远距离空气传播感染的呼吸道飞沫的大小范围决定了有针对性的干预方法。然而,确切的大小范围仍然未知,影响参数也未确定。在此,我们研究了 COVID-19 疫情爆发的四个报告场所中呼吸道飞沫的大小分辨传输和归宿。我们利用了一个瞬态数量平衡模型、一组过期飞沫粒度分布、现有的粒度分辨沉降率和过滤效率公式以及国际辐射防护委员会的沉积模型。这使我们能够获得室内空气中呼气飞沫的尺寸分辨浓度、吸入空气中飞沫核的尺寸分辨数量以及沉积在整个呼吸道中的飞沫数量。新定义的呼出飞沫在空气中传播的大小范围取决于所考虑的感染场所的有效稀释流速。为确定涉及远距离空气传播的飞沫大小,提出了三个标准。空气传播飞沫的初始直径通常为 0.1-4-6 µm,在四个场所中,每个指数病例每小时产生的飞沫量为 0.38-0.42 nL/h。这种新估算的空气传播飞沫量为病毒载量法估算感染量子产生率提供了重要输入。我们的粒度分辨估算揭示出,在通风、沉降、失活和过滤等去除效应以及瞬时稀释效应之后,空气传播粒度范围内的过期感染飞沫中只有极少部分能够存活。这些飞沫残留在室内空气中,有可能造成远距离空气传播。空气传播的大小范围取决于房间内与大小相关的稀释能力。
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引用次数: 0
Measured PM2.5 indoors and outdoors related to smoking prevalence by Zip code using 14,400 low-cost monitors in California, Washington, and Oregon 使用加利福尼亚州、华盛顿州和俄勒冈州的 14 400 个低成本监测器,按邮政编码测量室内外 PM2.5 与吸烟率的关系
Pub Date : 2024-08-22 DOI: 10.1016/j.indenv.2024.100043
Lance Wallace

Low-cost monitors have made possible for the first time measurements of long-term (months to years) potential indoor exposures to fine particles. Indoor and outdoor measurements made over nearly 5 years (2017–2021) by the largest network of low-cost monitors in the United States (PurpleAir) are compared to the prevalence of adult smokers in 1650 Zip codes within the three West Coast states of California, Oregon, and Washington. The results show that mean potential indoor exposures above the 75th percentile of adult smoking prevalence are more than 50 % higher than those below the 25th percentile. Mean outdoor concentrations are also elevated, but by a smaller amount (∼ 20 %). Both comparisons are significant at the p < 0.001 level. The elevation of PM2.5 concentrations with increasing smoking prevalence is evidence of environmental disparities in income, education, and other socioeconomic indices. The relatively stronger effect on indoor rather than outdoor PM2.5 exposures highlights the importance of including indoor measurements when possible in environmental justice studies.

低成本监测仪首次实现了对细颗粒物长期(数月至数年)潜在室内暴露的测量。美国最大的低成本监测器网络(PurpleAir)在近 5 年(2017-2021 年)内进行的室内和室外测量结果与西海岸三个州(加利福尼亚州、俄勒冈州和华盛顿州)1650 个邮政编码中的成人吸烟率进行了比较。结果显示,高于成人吸烟率第 75 百分位数的平均潜在室内辐照度比低于第 25 百分位数的辐照度高出 50% 以上。室外的平均浓度也有所升高,但升高幅度较小(± 20%)。这两项比较在 p < 0.001 水平上都有意义。PM2.5浓度随着吸烟率的增加而升高,这证明了收入、教育和其他社会经济指数方面的环境差异。对室内而非室外 PM2.5 暴露的影响相对较强,这凸显了在环境正义研究中尽可能纳入室内测量的重要性。
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引用次数: 0
Effectiveness of triethylene glycol disinfection on airborne MS2 bacteriophage under diverse building operational parameters 不同建筑运行参数下三甘醇消毒对空气传播的 MS2 噬菌体的效果
Pub Date : 2024-08-13 DOI: 10.1016/j.indenv.2024.100042
Zuraimi Sultan , Irvan Luhung , Ngu War Aung , Akira Uchida , Arulmani Natarajan , Santhi Puramadathil , Jiayu Li , Stephan Schuster , Stefano Schiavon

Research on triethylene glycol (TEG) use to disinfect airborne microorganisms have been conducted in non-realistic chamber settings. This study assesses how air temperature, humidity, HVAC settings, and filtration impact TEG's effectiveness in deactivating a common SARS-CoV-2 substitute, MS2 bacteriophage, in a simulated non-occupied office-sized chamber. The chamber was served by a dedicated HVAC system operating at 22.0, 23.5 and 25.0 °C, at 40, 55 and 70 % relative humidity, at 0, 3 and 6 air change per hour (ACH) recirculation, at 0.8, 2.5 and 5.0 ACH outdoor ventilation and at no, MERV8 and MERV14 filtration status. Airborne MS2 log10 reductions in the presence of TEG increased linearly over time and we noted a higher MS2 inactivation rate with higher TEG concentration. The estimated TEG concentration needed for a one-log inactivation of the MS2 within an hour was 0.44 mg/m3. The efficacy of TEG declined with the increase in temperature from 22.0 to 25.0 °C, peaked at 55 % RH, increased with higher recirculation rates but decreased with increasing ventilation rates and higher efficiency filters. The results of our study suggest that the optimum environmental and building conditions for TEG performance is at 22.0 or 23.5 °C air temperature, 55 % relative humidity, 0.8 ACH ventilation rate and 6 ACH recirculation rate. By conducting experiments in simulated office conditions, this study closes significant knowledge gaps in TEG performance application.

有关使用三甘醇(TEG)对空气中的微生物进行消毒的研究都是在非真实的室内环境中进行的。本研究评估了空气温度、湿度、HVAC 设置和过滤如何影响 TEG 在模拟非占用办公室大小的试验室中灭活常见 SARS-CoV-2 替代品 MS2 噬菌体的效果。模拟室由专用的暖通空调系统提供服务,温度分别为 22.0、23.5 和 25.0 °C,相对湿度分别为 40、55 和 70 %,再循环换气次数分别为 0、3 和 6 次/小时,室外通风换气次数分别为 0.8、2.5 和 5.0 次/小时,过滤状态分别为无过滤、MERV8 和 MERV14。在有 TEG 的情况下,空气中的 MS2 log10 减少量随时间呈线性增长,我们注意到 TEG 浓度越高,MS2 失活率越高。一小时内使 MS2 失活一个对数所需的 TEG 浓度估计为 0.44 毫克/立方米。TEG 的功效随着温度从 22.0 ° C 升至 25.0 ° C 而下降,在相对湿度为 55 % 时达到峰值,随着再循环率的提高而增加,但随着通风率和高效过滤器的增加而降低。我们的研究结果表明,TEG 性能的最佳环境和建筑条件是 22.0 或 23.5 ° C 的气温、55 % 的相对湿度、0.8 ACH 的通风率和 6 ACH 的再循环率。通过在模拟办公室条件下进行实验,本研究填补了 TEG 性能应用方面的重大知识空白。
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引用次数: 0
Optimal operations of gaspers for minimizing the exposure risks of airborne disease transmission in an economy-class aircraft cabin 最大限度降低经济舱内空气传播疾病暴露风险的最佳充气机操作方法
Pub Date : 2024-08-12 DOI: 10.1016/j.indenv.2024.100041
Yiding Zhou , Yunge Hou , Chun Chen , Ruoyu You

Overhead gaspers with adjustable open ratios and flow directions can alter the airflow pattern in aircraft cabins and consequently influence airborne infectious diseases transmission. To achieve the optimal operations of gaspers for minimizing the passengers’ exposure risks, this study developed a Bayesian optimization method based on computational fluid dynamics (CFD). A seven-row, single-aisle, fully occupied, economy-class aircraft cabin was used for the numerical investigation. Two air distribution systems, i.e., a mixing ventilation system and a personalized displacement ventilation system, were considered. First, the open ratios of all the gaspers were optimized by the CFD-based Bayesian optimization method. The optimal operations of gaspers were determined with only 20 trials calculated by CFD using the Bayesian optimization. With the optimal open ratios of all the gaspers, the number of relatively high-risk passengers (exposure index over 0.95) was effectively reduced by at least 55% and 86% under the mixing ventilation and the personalized displacement ventilation, respectively, when compared with the results with all the gaspers turned off. Next, the optimal open ratios and flow directions of the gaspers near the index passenger were also determined by the proposed method. With the optimized operations of gaspers, the number of relatively high-risk passengers was effectively reduced by at least 50% and 67% under the mixing ventilation and the personalized displacement ventilation, respectively.

可调节开孔率和流向的天花板气流器可改变飞机客舱内的气流模式,从而影响空气传播传染病。为了优化气流器的运行,最大限度地降低乘客的暴露风险,本研究开发了一种基于计算流体动力学(CFD)的贝叶斯优化方法。数值研究使用了一个七排、单通道、满员经济舱客舱。研究考虑了两种空气分配系统,即混合通风系统和个性化位移通风系统。首先,通过基于 CFD 的贝叶斯优化方法优化了所有气流器的开放比率。利用贝叶斯优化法,仅通过 CFD 计算的 20 次试验,就确定了加气机的最佳运行方式。与关闭所有加气机的结果相比,在所有加气机的最佳开启率下,混合通风和个性化置换通风下相对高危乘客(暴露指数超过 0.95)的数量分别有效减少了至少 55% 和 86%。接下来,还通过所提出的方法确定了指数乘客附近气流器的最佳开度比和流向。在混合通风和个性化位移通风条件下,通过优化气体发生器的运行,相对高风险乘客的数量分别有效减少了至少 50%和 67%。
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引用次数: 0
A novel method for establishing typical daily profile of PM concentrations in underground railway stations 建立地下铁道车站可吸入颗粒物典型日浓度曲线的新方法
Pub Date : 2024-08-10 DOI: 10.1016/j.indenv.2024.100040
Valisoa M. Rakotonirinjanahary , Suzanne Crumeyrolle , Mateusz Bogdan , Benjamin Hanoune

The air quality in underground railway stations (URS) poses a significant public health concern due to extremely high concentrations of particulate matter: PM10 and PM2.5. Indeed, PM sources are strong and numerous, such as train braking and tunnel effect and URS are often confined spaces with low air change rates. Despite multiple PM measurements within URS, the variability of those concentrations from stations to stations is still poorly understood. We present here a methodology for establishing a daily profile of particle mass concentrations, based on a 5-year long measurement series in a Parisian URS. This approach incorporates an extensive data cleaning process based on the identification of URS operation periods and physically inconsistent or mathematically aberrant data, together with a linear regression model. This methodology delivers three usable outcomes: a typical profile for weekdays, a typical profile for weekends, and a PM concentration Daily Amplitude Coefficient (DAC) for the considered period. The DAC is a daily metric of the pollution levels, that enables the analysis of temporal trends and facilitates the comparison with other data with other acquisition frequency. The methodology developed here in a specific URS for PM10 measurements can be easily applied to different particle size fractions or to other measured parameters exhibiting a daily profile. Weekdays PM10 concentrations exhibit two distinct peaks corresponding to morning and evening rush hours, with an average daytime concentration of 193 µg/m³. These peaks are delayed by ∼1 hour compared to the train traffic. Weekends show consistently lower PM levels with no observable peaks, averaging 157 µg/m³ during the day. Our analysis reveals the long-term temporal evolution of PM concentration within the URS, highlighting seasonal patterns with higher PM10 concentrations observed in summer (up to 400 µg/m3) and lower values in winter (down to 250 µg/m3). This indoor seasonal evolution is not correlated with the outdoor temporal evolution, showing higher concentrations during the winter. Furthermore, our results show that the optimal period (DAC∼1) for conducting experiments to obtain reliable profiles is during the spring months (April, May, June).

由于颗粒物浓度极高,地下火车站(URS)的空气质量对公众健康构成了严重威胁:PM10 和 PM2.5。事实上,可吸入颗粒物的来源既多又强,例如列车制动和隧道效应,而且地下铁道站通常是密闭空间,换气率低。尽管对 URS 内的 PM 进行了多次测量,但人们对这些浓度在不同站点之间的变化仍然知之甚少。我们在此介绍一种基于巴黎 URS 长达 5 年的测量系列,建立每日颗粒物质量浓度曲线的方法。这种方法包括一个广泛的数据清理过程,该过程基于对 URS 运行期、物理上不一致或数学上异常数据的识别,以及一个线性回归模型。该方法提供了三种可用的结果:工作日的典型剖面图、周末的典型剖面图以及考虑期间的可吸入颗粒物浓度日振幅系数(DAC)。日振幅系数是污染水平的日指标,可用于分析时间趋势,并便于与其他采集频率的数据进行比较。在此针对 PM10 测量的特定 URS 中开发的方法可以很容易地应用于不同的粒径分数或表现出日轮廓的其他测量参数。平日的 PM10 浓度在早晚高峰时段呈现出两个明显的峰值,白天的平均浓度为 193 µg/m³。与火车交通相比,这些峰值延迟了 1 小时。周末的可吸入颗粒物浓度一直较低,没有明显的峰值,白天的平均浓度为 157 µg/m³。我们的分析揭示了 URS 内可吸入颗粒物浓度的长期时间演变,突出了季节性模式,夏季 PM10 浓度较高(高达 400 微克/立方米),冬季较低(低至 250 微克/立方米)。室内的季节性变化与室外的时间性变化并不相关,冬季的浓度更高。此外,我们的研究结果表明,春季(4 月、5 月、6 月)是进行实验以获得可靠曲线的最佳时期(DAC∼1)。
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引用次数: 0
Exploring how social housing residents interact with building openings in a hot-humid climate 探索在湿热气候下社会住房居民如何与建筑开口互动
Pub Date : 2024-08-10 DOI: 10.1016/j.indenv.2024.100038
Solange Maria Leder , Andreia Cardoso de Oliveira , Celina Pinto Leão , Erivaldo Lopes de Souza

In a hot-humid climate, natural ventilation is the most recommended strategy for obtaining thermal comfort indoors. The residents' behavior in opening windows and doors to promote natural ventilation is crucial for predicting thermal comfort, especially for low-income housing where energy costs can exceed household budgets. This study identifies residents’ behavior in social housing in northeast Brazil (a hot-humid climate), focusing on actions to regulate thermal comfort with natural ventilation. The methodology comprehends field research, surveys, data processing, and analysis. Interviews with 375 individuals across two social housing complexes reveal the significant role of security and cultural factors in window control behavior. The results highlight the considerable role of security and cultural factors in shaping occupant behavior concerning window control. The residents indicated that they are stimulated to open the windows and doors right after they wake up and close them at bedtime or when leaving the house. Occupancy is a significant driving factor, but the sleep period (unconscious state) plays a crucial role in determining the closure of openings, even to housing units with a 2.0 m high wall on the plot land limits and security bars on windows. This study contributes to the understanding of the complex interplay between security, cultural factors, and thermal comfort regulation, proposing valuable insights for design and policy interventions aimed at improving living conditions in similar contexts.

在湿热气候条件下,自然通风是获得室内热舒适度的最推荐策略。居民打开门窗促进自然通风的行为对于预测热舒适度至关重要,尤其是对于能源成本可能超出家庭预算的低收入住房而言。本研究确定了巴西东北部(湿热气候)社会住房中居民的行为,重点关注利用自然通风调节热舒适度的行动。研究方法包括实地研究、调查、数据处理和分析。对两个社会住宅区的 375 人进行的访谈显示,安全和文化因素在窗户控制行为中起着重要作用。结果凸显了安全和文化因素在影响住户窗户控制行为方面的重要作用。居民们表示,他们在起床后会立即打开门窗,在睡觉前或离开家时则会关闭门窗。占用率是一个重要的驱动因素,但睡眠时间(无意识状态)在决定是否关闭门窗方面起着至关重要的作用,即使是在小区地界上有 2.0 米高的围墙、窗户上有防盗栏的住房单元中也是如此。这项研究有助于理解安全、文化因素和热舒适调节之间复杂的相互作用,为旨在改善类似情况下居住条件的设计和政策干预提出了宝贵的见解。
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引用次数: 0
Should we use ceiling fans indoors to reduce the risk of transmission of infectious aerosols? 我们是否应该在室内使用吊扇来降低传染性气溶胶的传播风险?
Pub Date : 2024-08-08 DOI: 10.1016/j.indenv.2024.100039
Jiayu Li , Sultan Zuraimi , Stefano Schiavon

The effects of ceiling fans on the transmission of infectious aerosols remain poorly understood, leading to conflicting recommendations. We conducted repeated experiments in a well-controlled chamber with a typical mixing ventilation system at three different ventilation rates with and without ceiling fans. We evaluated airborne infection risks for short- and long-range transmission routes based on size-resolved tracer particles measured at various locations. We found that the mixing ventilation without fans only effectively diluted the airborne particle concentration for the long-range route but not for the short-range. By using ceiling fans to enhance air mixing, tracer particles were distributed more homogeneously throughout the room, leading to up to 77 % reduction in short-range particle exposure while a slight increase of less than 14 % in long-range exposure. Based on the dilution-based Wells-Riley model, the changes in particle concentration translated to a maximum 47 % reduction in short-range infection risk and a marginal 4 % increase for long-range transmission. Based on the dilution factors obtained from the experiments, we developed a decision-making tool that uses the ventilation rate, the number of individuals at short- and long-range, and the disease's transmissibility to decide whether the use of ceiling fans is beneficial. Deploying ceiling fans always reduces the concentration of particles in the short range and, assuming a relationship between particles and pathogens, this directly translates to a diminished short-range risk. Based on the modeling of the overall risk, the benefits of fans are highest when the room is ventilated according to code, when masking measures are in place, and when the pathogen is not highly contagious.

人们对吊扇对传染性气溶胶传播的影响仍然知之甚少,因此提出了一些相互矛盾的建议。我们在一个具有典型混合通风系统的控制良好的密室中,以三种不同的通风率(有吊扇和无吊扇)进行了重复实验。我们根据在不同位置测量到的尺寸分辨示踪粒子,评估了短程和远程传播途径的空气传播感染风险。我们发现,不带风扇的混合通风系统只能有效稀释远距离传播途径的空气中的颗粒浓度,而不能有效稀释近距离传播途径的空气中的颗粒浓度。通过使用吊扇加强空气混合,示踪粒子在整个房间内的分布更加均匀,从而使短程粒子暴露量减少了 77%,而长程暴露量则略有增加,增幅不到 14%。根据基于稀释的 Wells-Riley 模型,粒子浓度的变化导致短程感染风险最多降低 47%,而长程传播风险仅增加 4%。根据实验得出的稀释因子,我们开发了一种决策工具,利用通风率、短距离和长距离的人数以及疾病的传播性来决定使用吊扇是否有益。安装吊扇总是会降低短距离内的微粒浓度,假设微粒和病原体之间存在某种关系,这直接转化为短距离风险的降低。根据整体风险建模,当房间通风符合规范、采取了遮蔽措施、病原体传染性不强时,风扇的益处最大。
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引用次数: 0
An original device to assess the respiratory impact of indoor air VOCs mixture using an in vitro approach 采用体外方法评估室内空气挥发性有机化合物混合物对呼吸系统影响的独创装置
Pub Date : 2024-07-21 DOI: 10.1016/j.indenv.2024.100037
Plaisance Hervé , Costarramone Nathalie , Dalliès Gaëlle , Al Zallouha Margueritta , Achard Sophie , Desauziers Valérie

Exposure to indoor air pollution, particularly volatile organic compounds (VOCs), has been recognized as a risk factor in the development of respiratory and allergic diseases. VOCs are mainly emitted continuously at low concentrations from construction furniture and decoration products. Measurement campaigns carried out in new dwellings in France have shown that aldehydes predominate with a tendency to decrease formaldehyde concentrations and to increase those in hexanal. As the main route of VOCs exposure is inhalation, this project assessed the impact of a mixture of 17 VOCs representative of indoor air (in quality and quantity) on respiratory health using an in vitro approach. This original work was based on the set-up of an experimental device, combining a gas generation and dilution bench and exposure to the air-liquid interface (ALI) adapted to the reconstructed human airway epithelium model. The VOC mixture was enriched with formaldehyde or hexanal in different proportions (from 20 to 240 µg.m−3) to study the biological impact of these aldehydes after repeated exposures of airway epithelium. After examination of the stability of the VOC concentrations in generated mixtures and the found of the optimal operating conditions for the dynamic gas generating system, the gaseous mixtures were distributed to the epithelium using the ALI exposure system providing direct contact between the epithelium and the tested mixtures. Our device lead to reproduce real conditions of human exposure. The results showed that the inflammatory response, assessed by the production of four cytokines, varied according to the nature of the aldehyde present in the VOC mixture (formaldehyde or hexanal), its concentration, and the duration and number of exposures applied. The most original and innovative results concern those obtained with hexanal, pollutant under-researched. Our results showed that this aldehyde could pose risks to respiratory health.

接触室内空气污染,尤其是挥发性有机化合物(VOCs),已被公认为是导致呼吸道疾病和过敏性疾病的一个危险因素。挥发性有机化合物主要从建筑家具和装饰产品中以低浓度持续排放。在法国新住宅中开展的测量活动表明,醛类占主导地位,甲醛浓度呈下降趋势,而己醛浓度则呈上升趋势。由于接触挥发性有机化合物的主要途径是吸入,该项目采用体外方法评估了室内空气中具有代表性的 17 种挥发性有机化合物混合物(质量和数量)对呼吸系统健康的影响。这项原创性工作以实验装置的设置为基础,该装置结合了气体生成和稀释工作台以及与重建人体气道上皮细胞模型相适应的空气-液体界面(ALI)暴露。VOC 混合物中富含不同比例的甲醛或己醛(20 至 240 µg.m-3),以研究这些醛类物质在反复接触气道上皮后对生物的影响。在检测了生成混合物中挥发性有机化合物浓度的稳定性并找到动态气体生成系统的最佳运行条件后,使用 ALI 暴露系统将气态混合物分配到上皮细胞,使上皮细胞与测试混合物直接接触。我们的设备能够再现人体接触的真实情况。结果表明,炎症反应(通过四种细胞因子的产生来评估)随挥发性有机化合物混合物中存在的醛的性质(甲醛或己醛)、浓度以及接触时间和次数的不同而变化。最具原创性和创新性的结果涉及对研究不足的污染物己醛。我们的研究结果表明,这种醛可能会对呼吸系统健康造成危害。
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引用次数: 0
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Indoor Environments
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