Pub Date : 2025-11-14DOI: 10.1016/j.cclet.2025.112116
Jing Guo , Chunhui Luo , Peng Li , Mao Ye , Zhihua Qiao , Yubo Wu , Huiqin Hu , Xubiao Luo , Liming Yang , Yulin Cai , Pengwei Li , Kai Zhu , Cheng Fu , Bing Yu , Yueying Chen , Shichang Wang , Ting Wang , Chongchong Qi , Zirou Liu , Dongmei Huang , Jianmin Ma
Sustainable development for our life is important task, which is driven by key materials and technologies. In this roadmap, we discuss three main aspects in addressing environmental questions, green chemical processes and energy challenges. They are included, such as gas treatment and separation, wastewater treatment, waste gas treatment, solid waste treatment, lithium extraction, hydrogen production, water splitting, CO2 reduction, photocatalytic clean technologies, plastic degradation, fuel cells, lithium batteries, sodium batteries, aqueous batteries, solid state batteries, metal air batteries and supercapacitors. Their status, challenges, progress and future perspectives are also discussed. We hope that this paper can give clear views on sustainable development in materials and technologies.
{"title":"Roadmap on sustainable materials and technologies","authors":"Jing Guo , Chunhui Luo , Peng Li , Mao Ye , Zhihua Qiao , Yubo Wu , Huiqin Hu , Xubiao Luo , Liming Yang , Yulin Cai , Pengwei Li , Kai Zhu , Cheng Fu , Bing Yu , Yueying Chen , Shichang Wang , Ting Wang , Chongchong Qi , Zirou Liu , Dongmei Huang , Jianmin Ma","doi":"10.1016/j.cclet.2025.112116","DOIUrl":"10.1016/j.cclet.2025.112116","url":null,"abstract":"<div><div>Sustainable development for our life is important task, which is driven by key materials and technologies. In this roadmap, we discuss three main aspects in addressing environmental questions, green chemical processes and energy challenges. They are included, such as gas treatment and separation, wastewater treatment, waste gas treatment, solid waste treatment, lithium extraction, hydrogen production, water splitting, CO<sub>2</sub> reduction, photocatalytic clean technologies, plastic degradation, fuel cells, lithium batteries, sodium batteries, aqueous batteries, solid state batteries, metal air batteries and supercapacitors. Their status, challenges, progress and future perspectives are also discussed. We hope that this paper can give clear views on sustainable development in materials and technologies.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 2","pages":"Article 112116"},"PeriodicalIF":8.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.cclet.2025.112114
Yunpeng Wang , Zhuxin Lyu , Yueming Sun, Yunqian Dai
Supported noble‐metal catalysts often suffer from nanoparticle sintering, resulting in rapid deactivation under high‐temperature conditions. We report hierarchically porous spinel type high-entropy oxide (S-HEO) nanofibers, (CrMnFeCoMg)3O4, as robust supports for Pt nanoparticles. The porous structure (38.5 m2/g) endows thermal stability, preserving porosity after 880 °C calcination. The porous Pt/S-HEO-500 exhibits exceptional sinter-resistance. Under 500 °C calcination, Pt exhibits only a 0.2 nm growth increment, owing to the physical confinement and strong metal–support interactions. For Pt/S-HEO-500, the T50 (50 % conversion temperature) for CO oxidation was merely 9 °C higher than that without calcination, with 100 % conversion retained over 100 h of steady-state operation. These findings position porous spinel HEO nanofibers as a versatile platform for designing sinter-resistant noble-metal catalysts in high-temperature applications.
{"title":"Entropy-stabilized nanoporous structures enable sintering-resistant Pt species","authors":"Yunpeng Wang , Zhuxin Lyu , Yueming Sun, Yunqian Dai","doi":"10.1016/j.cclet.2025.112114","DOIUrl":"10.1016/j.cclet.2025.112114","url":null,"abstract":"<div><div>Supported noble‐metal catalysts often suffer from nanoparticle sintering, resulting in rapid deactivation under high‐temperature conditions. We report hierarchically porous spinel type high-entropy oxide (S-HEO) nanofibers, (CrMnFeCoMg)<sub>3</sub>O<sub>4</sub>, as robust supports for Pt nanoparticles. The porous structure (38.5 m<sup>2</sup>/g) endows thermal stability, preserving porosity after 880 °C calcination. The porous Pt/S-HEO-500 exhibits exceptional sinter-resistance. Under 500 °C calcination, Pt exhibits only a 0.2 nm growth increment, owing to the physical confinement and strong metal–support interactions. For Pt/S-HEO-500, the <em>T</em><sub>50</sub> (50 % conversion temperature) for CO oxidation was merely 9 °C higher than that without calcination, with 100 % conversion retained over 100 h of steady-state operation. These findings position porous spinel HEO nanofibers as a versatile platform for designing sinter-resistant noble-metal catalysts in high-temperature applications.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 3","pages":"Article 112114"},"PeriodicalIF":8.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.cclet.2025.112099
Shiwen Song , Mingyang Zhao , Xiangrong Song , Huaidong Yu , Xin Xu , Dong Sun , Jingkai Gu
PEGylation, the controlled covalent conjugation of polyethylene glycol to therapeutics, enhances therapeutic efficacy through optimized pharmacokinetics. However, to date no high-molecular-weight PEGylated small-molecule prodrugs have received regulatory approval. This technological gap can be partially attributed to the exponential proliferation of metabolic intermediates resulting from multi-payload conjugation strategies, which introduces unprecedented analytical complexities in metabolite profiling and pharmacokinetic characterization. To address this challenge, we developed a liquid chromatography-triple-quadrupole/time-of-flight mass spectrometry platform for PEG20k-(irinotecan)3, a Phase III clinical candidate. Our methodology employs payload stoichiometry-based chromatographic resolution for clustering isomeric PEG species. Complementarily, diagnostic product ions at m/z 699.83, 569.27, and 587.28 enable systematic differentiation between double-loaded, single-loaded, and released irinotecan payload. This approach successfully identifies eight metabolic clusters spanning from PEG-conjugates, cleaved PEG segments, and released small-molecule species. Its demonstrated capacity to deconvolute complex metabolic profiles—through payload-stoichiometry based chromatographic resolution coupled with diagnostic ion analysis—positions this workflow as an attractive tool for accelerating the development of PEGylated small-molecule therapeutics.
{"title":"Unraveling metabolic complexity of multi-payload PEG-irinotecan prodrug: A deconvolution-based LC-Q-TOF MS approach for preclinical pharmacokinetic characterization","authors":"Shiwen Song , Mingyang Zhao , Xiangrong Song , Huaidong Yu , Xin Xu , Dong Sun , Jingkai Gu","doi":"10.1016/j.cclet.2025.112099","DOIUrl":"10.1016/j.cclet.2025.112099","url":null,"abstract":"<div><div>PEGylation, the controlled covalent conjugation of polyethylene glycol to therapeutics, enhances therapeutic efficacy through optimized pharmacokinetics. However, to date no high-molecular-weight PEGylated small-molecule prodrugs have received regulatory approval. This technological gap can be partially attributed to the exponential proliferation of metabolic intermediates resulting from multi-payload conjugation strategies, which introduces unprecedented analytical complexities in metabolite profiling and pharmacokinetic characterization. To address this challenge, we developed a liquid chromatography-triple-quadrupole/time-of-flight mass spectrometry platform for PEG20k-(irinotecan)<sub>3</sub>, a Phase III clinical candidate. Our methodology employs payload stoichiometry-based chromatographic resolution for clustering isomeric PEG species. Complementarily, diagnostic product ions at <em>m/z</em> 699.83, 569.27, and 587.28 enable systematic differentiation between double-loaded, single-loaded, and released irinotecan payload. This approach successfully identifies eight metabolic clusters spanning from PEG-conjugates, cleaved PEG segments, and released small-molecule species. Its demonstrated capacity to deconvolute complex metabolic profiles—through payload-stoichiometry based chromatographic resolution coupled with diagnostic ion analysis—positions this workflow as an attractive tool for accelerating the development of PEGylated small-molecule therapeutics.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 2","pages":"Article 112099"},"PeriodicalIF":8.9,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1016/j.cclet.2025.112096
Yongliang Ban , Meng Zhang , Jianya He , Chunfeng Shao , Zhongliao Wang , Wei Zhao , Kai Dai
The development of efficient and cost-effective non-precious-metal single-atom catalysts (SACs) is crucial for advancing the practical application of electrocatalytic CO2 reduction (CO2RR). However, identifying highly active metal atoms and designing catalysts with uniform active center structures remain significant challenges. To address this, we developed a generic pyrolysis method to synthesize a series of transition metal-based SACs with atomically dispersed metal anchored on carbon nitride support (M-C3N4, M = Fe, Ni, Cu). Benefiting from the unique electronic structure of the Fe-N4 sites supported on C3N4, the Fe-C3N4 catalyst demonstrated exceptional performance, achieving a CO Faradaic efficiency of 99.6 % and maintaining excellent stability. Theoretical calculations indicate that the Fe site exhibits a relatively stronger interaction with the *COOH intermediate, thereby helping to lower the energy barrier of the CO2 protonation process. This study provides valuable theoretical insights and practical synthesis strategies for designing high-performance non-precious-metal SACs for CO2RR.
开发高效、经济的非贵金属单原子催化剂对于推进电催化CO2还原（CO2RR）的实际应用至关重要。然而，鉴定高活性金属原子和设计具有均匀活性中心结构的催化剂仍然是一个重大挑战。为了解决这个问题，我们开发了一种通用的热解方法来合成一系列过渡金属基SACs，这些SACs将原子分散的金属锚定在氮化碳载体上（M- c3n4, M = Fe, Ni, Cu）。得益于C3N4上Fe-N4位独特的电子结构，Fe-C3N4催化剂表现出优异的性能，CO法拉第效率达到99.6 %，并保持了优异的稳定性。理论计算表明，Fe位点与*COOH中间体的相互作用相对较强，从而有助于降低CO2质子化过程的能垒。该研究为设计高性能的CO2RR非贵金属sac提供了有价值的理论见解和实用的合成策略。
{"title":"Atomically dispersed Fe‑N4 sites on g‑C3N4 enable highly selective CO2‑to‑CO electrocatalysis","authors":"Yongliang Ban , Meng Zhang , Jianya He , Chunfeng Shao , Zhongliao Wang , Wei Zhao , Kai Dai","doi":"10.1016/j.cclet.2025.112096","DOIUrl":"10.1016/j.cclet.2025.112096","url":null,"abstract":"<div><div>The development of efficient and cost-effective non-precious-metal single-atom catalysts (SACs) is crucial for advancing the practical application of electrocatalytic CO<sub>2</sub> reduction (CO<sub>2</sub>RR). However, identifying highly active metal atoms and designing catalysts with uniform active center structures remain significant challenges. To address this, we developed a generic pyrolysis method to synthesize a series of transition metal-based SACs with atomically dispersed metal anchored on carbon nitride support (M-C<sub>3</sub>N<sub>4</sub>, M = Fe, Ni, Cu). Benefiting from the unique electronic structure of the Fe-N<sub>4</sub> sites supported on C<sub>3</sub>N<sub>4</sub>, the Fe-C<sub>3</sub>N<sub>4</sub> catalyst demonstrated exceptional performance, achieving a CO Faradaic efficiency of 99.6 % and maintaining excellent stability. Theoretical calculations indicate that the Fe site exhibits a relatively stronger interaction with the *COOH intermediate, thereby helping to lower the energy barrier of the CO<sub>2</sub> protonation process. This study provides valuable theoretical insights and practical synthesis strategies for designing high-performance non-precious-metal SACs for CO<sub>2</sub>RR.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 112096"},"PeriodicalIF":8.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.cclet.2025.112054
Yongqiang Ji , Donglin Jia , Fan Xu , Zhengwei Li , Lin Zhang , Le Li , Hengwei Qiu
In recent years, AgBiS2 nanocrystals (NCs) have emerged as a research hotspot in the field of solar cells due to their excellent optoelectronic properties and environmentally friendly characteristics. Although the theoretical power conversion efficiency (PCE) of AgBiS2 NC solar cells can reach up to 26%, the current best device only achieved a PCE of 10.84%. Such an enormous efficiency gap is primarily caused by the complex surface defects, severe carrier recombination, and undesirable energy-level mismatches. Therefore, this review comprehensively summarizes recent advancements in AgBiS2 NCs, including their crystal structures, optoelectronic properties, synthesis methods, ligand engineering, and device optimization. By fine-tuning synthesis conditions (e.g., temperature, precursor ratios) and employing ligand exchange strategies (solid-state/liquid-state), significant improvements in material performance have been realized. Furthermore, device structure optimization (e.g., transport layer selection, interface modification) and energy-level alignment engineering have further enhanced efficiency. Despite decent stabilities of AgBiS2 NCs, several challenges such as large-area uniformity and long-term device durability remain unraveled, which may be the major obstacles for their further commercialization. Future advancements in defect control, the development of novel ligands, and encapsulation technologies are expected to expand the applications of AgBiS2 NCs in flexible electronics, aerospace, and wearable devices.
{"title":"Rise of colloidal silver bismuth sulfide nanocrystals solar cells","authors":"Yongqiang Ji , Donglin Jia , Fan Xu , Zhengwei Li , Lin Zhang , Le Li , Hengwei Qiu","doi":"10.1016/j.cclet.2025.112054","DOIUrl":"10.1016/j.cclet.2025.112054","url":null,"abstract":"<div><div>In recent years, AgBiS<sub>2</sub> nanocrystals (NCs) have emerged as a research hotspot in the field of solar cells due to their excellent optoelectronic properties and environmentally friendly characteristics. Although the theoretical power conversion efficiency (PCE) of AgBiS<sub>2</sub> NC solar cells can reach up to 26%, the current best device only achieved a PCE of 10.84%. Such an enormous efficiency gap is primarily caused by the complex surface defects, severe carrier recombination, and undesirable energy-level mismatches. Therefore, this review comprehensively summarizes recent advancements in AgBiS<sub>2</sub> NCs, including their crystal structures, optoelectronic properties, synthesis methods, ligand engineering, and device optimization. By fine-tuning synthesis conditions (<em>e.g</em>., temperature, precursor ratios) and employing ligand exchange strategies (solid-state/liquid-state), significant improvements in material performance have been realized. Furthermore, device structure optimization (<em>e.g</em>., transport layer selection, interface modification) and energy-level alignment engineering have further enhanced efficiency. Despite decent stabilities of AgBiS<sub>2</sub> NCs, several challenges such as large-area uniformity and long-term device durability remain unraveled, which may be the major obstacles for their further commercialization. Future advancements in defect control, the development of novel ligands, and encapsulation technologies are expected to expand the applications of AgBiS<sub>2</sub> NCs in flexible electronics, aerospace, and wearable devices.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 2","pages":"Article 112054"},"PeriodicalIF":8.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.cclet.2025.112049
Junfeng Huang , Hongxin Chen , Yan Liao , Xiaowen Zhang , Zengzhu Zhang , Xiaoyu Su , Zihong Xie , Biao Li , Baode Shen , Pengfei Yue
Essential oils (EOs) are widely present in aromatic plants and possess a wide range of significant pharmacological activities such as antibacterial, antioxidant and anti-tumor properties. They have broad application prospects in medical care, food, agriculture and other fields. However, their poor stability poses substantial challenges that significantly hinder their development and practical application. Metal-organic framework materials (MOFs), characterized by highly controllable structures, large specific surface areas, and stimuli-responsive release properties, have been extensively utilized in various fields such as drug delivery and food preservation. Due to their capacity to encapsulate and deliver EOs, MOFs have garnered considerable attention. In this review, we systematically summarize the structural features, types, and characteristics of MOFs, as well as the recent advancements in their application for controlled EO release. Furthermore, we focus on discussing engineering strategies aimed at enhancing the encapsulation, release, and delivery of EOs using MOFs. Finally, we briefly outline the existing challenges in the delivery of EOs using MOFs and present well-reasoned insights into prospective directions for future research.
{"title":"Metal-organic framework materials for encapsulation, release and delivery of essential oils: Engineering strategies and challenges","authors":"Junfeng Huang , Hongxin Chen , Yan Liao , Xiaowen Zhang , Zengzhu Zhang , Xiaoyu Su , Zihong Xie , Biao Li , Baode Shen , Pengfei Yue","doi":"10.1016/j.cclet.2025.112049","DOIUrl":"10.1016/j.cclet.2025.112049","url":null,"abstract":"<div><div>Essential oils (EOs) are widely present in aromatic plants and possess a wide range of significant pharmacological activities such as antibacterial, antioxidant and anti-tumor properties. They have broad application prospects in medical care, food, agriculture and other fields. However, their poor stability poses substantial challenges that significantly hinder their development and practical application. Metal-organic framework materials (MOFs), characterized by highly controllable structures, large specific surface areas, and stimuli-responsive release properties, have been extensively utilized in various fields such as drug delivery and food preservation. Due to their capacity to encapsulate and deliver EOs, MOFs have garnered considerable attention. In this review, we systematically summarize the structural features, types, and characteristics of MOFs, as well as the recent advancements in their application for controlled EO release. Furthermore, we focus on discussing engineering strategies aimed at enhancing the encapsulation, release, and delivery of EOs using MOFs. Finally, we briefly outline the existing challenges in the delivery of EOs using MOFs and present well-reasoned insights into prospective directions for future research.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 3","pages":"Article 112049"},"PeriodicalIF":8.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-31DOI: 10.1016/j.cclet.2025.112051
He Zhao , Qiangqiang Dong , Fengxue Liu , Ning Wang , Lijun Wang , Mingzhao Chen , Zhilong Jiang , Die Liu , Jun Wang , Pingshan Wang , Yiming Li
The structural principles of traditional Chinese mortise-and-tenon joints have inspired breakthroughs in supramolecular engineering. Nevertheless, substantial challenges remain in constructing nanoscale supramolecular architectures with precisely controlled giant dimensions. Herein, we report a precision-guided synthetic strategy for constructing giant 2D and 3D supramolecular architectures with rhomboidal motifs, which was achieved through a dovetail joint strategy. Initial assembly of bis-mortise ligand L1 with dovetail tenon ligand L2 in the presence of Cd2+ ions yielded the fundamental bis-rhombic supramolecule R1. Subsequent structural elaboration of the dovetail tenon motif enabled the development of multitopic ligands L3 and L4, which facilitated the construction of expanded architectures of the giant bis-propeller supramolecule R2 and tris-propeller supramolecule R3. The synthesized supramolecules R1–R3 were fully characterized multidimensional NMR spectroscopy, electrospray ionization mass spectrometry (ESI-MS), traveling wave ion mobility mass spectrometry (TWIM-MS), transmission electron microscopy (TEM), and atomic force microscopy (AFM). This work develops an innovative dovetail-joint assembly strategy for constructing rigid giant supramolecular architectures, establishing a new paradigm for precision engineering of complex 3D molecular systems.
{"title":"Dovetail joint strategy for constructing giant multi-propeller supramolecular architectures","authors":"He Zhao , Qiangqiang Dong , Fengxue Liu , Ning Wang , Lijun Wang , Mingzhao Chen , Zhilong Jiang , Die Liu , Jun Wang , Pingshan Wang , Yiming Li","doi":"10.1016/j.cclet.2025.112051","DOIUrl":"10.1016/j.cclet.2025.112051","url":null,"abstract":"<div><div>The structural principles of traditional Chinese mortise-and-tenon joints have inspired breakthroughs in supramolecular engineering. Nevertheless, substantial challenges remain in constructing nanoscale supramolecular architectures with precisely controlled giant dimensions. Herein, we report a precision-guided synthetic strategy for constructing giant 2D and 3D supramolecular architectures with rhomboidal motifs, which was achieved through a dovetail joint strategy. Initial assembly of bis-mortise ligand <strong>L1</strong> with dovetail tenon ligand <strong>L2</strong> in the presence of Cd<sup>2+</sup> ions yielded the fundamental bis-rhombic supramolecule <strong>R1</strong>. Subsequent structural elaboration of the dovetail tenon motif enabled the development of multitopic ligands <strong>L3</strong> and <strong>L4</strong>, which facilitated the construction of expanded architectures of the giant bis-propeller supramolecule <strong>R2</strong> and tris-propeller supramolecule <strong>R3</strong>. The synthesized supramolecules <strong>R1–R3</strong> were fully characterized multidimensional NMR spectroscopy, electrospray ionization mass spectrometry (ESI-MS), traveling wave ion mobility mass spectrometry (TWIM-MS), transmission electron microscopy (TEM), and atomic force microscopy (AFM). This work develops an innovative dovetail-joint assembly strategy for constructing rigid giant supramolecular architectures, establishing a new paradigm for precision engineering of complex 3D molecular systems.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 2","pages":"Article 112051"},"PeriodicalIF":8.9,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.cclet.2025.112039
Yanhui Zhong , Peisi Xie , Chengyi Xie , Lei Guo , Weiwei Chen , Shuyi Wang , Xiaoxiao Wang , Fuyue Wang , Zian Lin , Gongke Li , Zongwei Cai
Chiral amino acids (AAs) serve as essential building blocks of proteins and play vital physiological roles in living organisms. To achieve accurate, rapid, and high-throughput analysis of chiral AAs, this work proposed a methylbenzyl isocyanate (MBIC) derivatization strategy coupled with ultra-high performance liquid chromatography-mass spectrometry or trapped ion mobility spectrometry-mass spectrometry. The integration of a chiral carbon atom with a rigid urea-based structure can significantly enhance the separation of chiral MBIC-labeled AA enantiomers. This phenomenon can be attributed to the labeled l-AAs allow the carboxyl group to form intramolecular hydrogen bonds with the amino group in the rigid urea-based structure, whereas labeled d-AAs are unable to form such bonds. The method based on MBIC derivatization coupled with ultra-performance liquid chromatography-tandem mass spectrometry achieved simultaneous separation of 19 pairs of chiral AAs using only a C18 column within 30 min, enabling quantitatively detect twelve types of chiral AAs in the serum of healthy humans and Parkinson's patients. The distribution of twenty-four chiral AAs is observed in mouse brain using MBIC labeling-based matrix-assisted laser desorption/ionization-trapped ion mobility spectrometry-mass spectrometry imaging without prior separation. Our work elucidates the principles governing the separation of chiral AAs using derivatization methods, providing valuable guidance for the separation of chiral compounds.
{"title":"Rigid urea-based structures drive analysis of chiral amino acids","authors":"Yanhui Zhong , Peisi Xie , Chengyi Xie , Lei Guo , Weiwei Chen , Shuyi Wang , Xiaoxiao Wang , Fuyue Wang , Zian Lin , Gongke Li , Zongwei Cai","doi":"10.1016/j.cclet.2025.112039","DOIUrl":"10.1016/j.cclet.2025.112039","url":null,"abstract":"<div><div>Chiral amino acids (AAs) serve as essential building blocks of proteins and play vital physiological roles in living organisms. To achieve accurate, rapid, and high-throughput analysis of chiral AAs, this work proposed a methylbenzyl isocyanate (MBIC) derivatization strategy coupled with ultra-high performance liquid chromatography-mass spectrometry or trapped ion mobility spectrometry-mass spectrometry. The integration of a chiral carbon atom with a rigid urea-based structure can significantly enhance the separation of chiral MBIC-labeled AA enantiomers. This phenomenon can be attributed to the labeled <span>l</span>-AAs allow the carboxyl group to form intramolecular hydrogen bonds with the amino group in the rigid urea-based structure, whereas labeled <span>d</span>-AAs are unable to form such bonds. The method based on MBIC derivatization coupled with ultra-performance liquid chromatography-tandem mass spectrometry achieved simultaneous separation of 19 pairs of chiral AAs using only a C18 column within 30 min, enabling quantitatively detect twelve types of chiral AAs in the serum of healthy humans and Parkinson's patients. The distribution of twenty-four chiral AAs is observed in mouse brain using MBIC labeling-based matrix-assisted laser desorption/ionization-trapped ion mobility spectrometry-mass spectrometry imaging without prior separation. Our work elucidates the principles governing the separation of chiral AAs using derivatization methods, providing valuable guidance for the separation of chiral compounds.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 2","pages":"Article 112039"},"PeriodicalIF":8.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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