Pub Date : 2026-04-01Epub Date: 2025-09-02DOI: 10.1016/j.cclet.2025.111781
Xia Jiang , Yan-Xin Chen , Rui Chen , Hao-Yan Shi , Ke-Xian Li , Wen-Ya Zhong , Jian-Feng Li , Can-Zhong Lu
Thermo-photocatalytic CO2 conversion to C2 products exhibits high research value and industrial potential. Enhancing the catalyst’s adsorption activation for CO2 and H2O, along with multistep proton-coupled electron transfer (PCET) and C-C coupling, is crucial for achieving thermo-photocatalytic CO2 reduction conversion to C2 products with H2O as a proton source in a continuous process. In this paper, we explore a novel approach utilizing biochar to obtain catalysts with more defects and combine reducing biochar with MOF Materials (ZIF-67) to get a composite (ZIF-67/PC) with substantial CO2 and H2O adsorption activation capabilities and electron density gradients. Compared to PC and ZIF-67, the ZIF-67/PC exhibited excellent catalytic performance, particularly in obtaining a certain amount of C2 products (yield 5.59 µmol g-1 h-1, selectivity 55.96%). We also investigated the structure-function relationship of the catalyst and the contributions of thermal and light effects to the catalytic reaction, aiming to guide the establishment of efficient, high-throughput catalytic CO2 conversion technologies.
{"title":"Thermo-photocatalytic CO2 conversion with H2O to C2 products in a continuous process by ZIF-67/biochar composites","authors":"Xia Jiang , Yan-Xin Chen , Rui Chen , Hao-Yan Shi , Ke-Xian Li , Wen-Ya Zhong , Jian-Feng Li , Can-Zhong Lu","doi":"10.1016/j.cclet.2025.111781","DOIUrl":"10.1016/j.cclet.2025.111781","url":null,"abstract":"<div><div>Thermo-photocatalytic CO<sub>2</sub> conversion to C<sub>2</sub> products exhibits high research value and industrial potential. Enhancing the catalyst’s adsorption activation for CO<sub>2</sub> and H<sub>2</sub>O, along with multistep proton-coupled electron transfer (PCET) and C-C coupling, is crucial for achieving thermo-photocatalytic CO<sub>2</sub> reduction conversion to C<sub>2</sub> products with H<sub>2</sub>O as a proton source in a continuous process. In this paper, we explore a novel approach utilizing biochar to obtain catalysts with more defects and combine reducing biochar with MOF Materials (ZIF-67) to get a composite (ZIF-67/PC) with substantial CO<sub>2</sub> and H<sub>2</sub>O adsorption activation capabilities and electron density gradients. Compared to PC and ZIF-67, the ZIF-67/PC exhibited excellent catalytic performance, particularly in obtaining a certain amount of C<sub>2</sub> products (yield 5.59 µmol g<sup>-1</sup> h<sup>-1</sup>, selectivity 55.96%). We also investigated the structure-function relationship of the catalyst and the contributions of thermal and light effects to the catalytic reaction, aiming to guide the establishment of efficient, high-throughput catalytic CO<sub>2</sub> conversion technologies.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111781"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2024-12-14DOI: 10.1016/j.cclet.2024.110755
Zhi-Long Li , Hao-Fei Ni , Bo Zhuang , Kun Ding , Da-Wei Fu , Qiang Guo , Meng-Meng Lun
Ferroelastics have attracted considerable interest because of their promising uses in areas such as energy conversion, sensing technologies, and beyond. However, exploring ferroelastics with high-temperature dielectric switching and photoluminescence remains a challenge. Here, we have synthesized two ferroelastics (DMTP)PbBr3 (DMTP = N,N-dimethyl-1,2,3,6-tetrahydropyridine) and (DMTP)PbI3 under the guidance of halogen substitution strategy. (DMTP)PbI3 experiences the dielectric switching at 371 K, and upon halogen substitution, the strengthened intermolecular interactions lead to (DMTP)PbBr3 undergoing a similar switching at around 390 K. Additionally, two compounds both emit orange light under ultraviolet illumination. (DMTP)PbI3 has the photoluminescence quantum yield of 2.68 %, while (DMTP)PbBr3, due to the increased distortion of the inorganic part after halogen substitution, achieves the higher quantum yield of 12 %. This work offers meaningful perspectives on exploring the search for ferroelectrics with photoluminescence and high-temperature dielectric switching, and also demonstrates the rationality of the halogen substitution strategy.
{"title":"Halogen substitution strategy for regulating the photoluminescence and dielectric response of ferroelastics","authors":"Zhi-Long Li , Hao-Fei Ni , Bo Zhuang , Kun Ding , Da-Wei Fu , Qiang Guo , Meng-Meng Lun","doi":"10.1016/j.cclet.2024.110755","DOIUrl":"10.1016/j.cclet.2024.110755","url":null,"abstract":"<div><div>Ferroelastics have attracted considerable interest because of their promising uses in areas such as energy conversion, sensing technologies, and beyond. However, exploring ferroelastics with high-temperature dielectric switching and photoluminescence remains a challenge. Here, we have synthesized two ferroelastics (DMTP)PbBr<sub>3</sub> (DMTP = <em>N,N</em>-dimethyl-1,2,3,6-tetrahydropyridine) and (DMTP)PbI<sub>3</sub> under the guidance of halogen substitution strategy. (DMTP)PbI<sub>3</sub> experiences the dielectric switching at 371 K, and upon halogen substitution, the strengthened intermolecular interactions lead to (DMTP)PbBr<sub>3</sub> undergoing a similar switching at around 390 K. Additionally, two compounds both emit orange light under ultraviolet illumination. (DMTP)PbI<sub>3</sub> has the photoluminescence quantum yield of 2.68 %, while (DMTP)PbBr<sub>3</sub>, due to the increased distortion of the inorganic part after halogen substitution, achieves the higher quantum yield of 12 %. This work offers meaningful perspectives on exploring the search for ferroelectrics with photoluminescence and high-temperature dielectric switching, and also demonstrates the rationality of the halogen substitution strategy.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 110755"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-08-05DOI: 10.1016/j.cclet.2025.111669
Mengjiao Xie , Nadeeshani Nanayakkara , Yanbiao Liu
Sustainable and efficient solutions are essential to address increasingly critical environmental issues, particularly in the field of pollutant removal and resource recovery. The latest research has shown that pulsed electrochemistry significantly contributes to these goals by precisely altering the local reaction environment, accelerating the reaction kinetics and decreasing the overall energy requirements. However, knowledge gaps exist in dynamic evolution mechanism of electric double layer (EDL) in this technology, and challenges remain toward fully implementation of this promising technology. In this review, the fundamentals of pulsed electrochemistry and its connection to the theoretical models of EDL are comprehensively presented. The critical parameters (e.g., duty ratio, frequency and waveform) for boosting the performance of the system are systematically discussed and the typical electrochemical reactions that occur with pulsed electrochemistry are outlined. The proposed pulsed electrochemistry methodologies tailored for environmental applications are also reviewed in detail. Finally, future opportunities and challenges of this promising but fledgling field are discussed, with the expectation that this technology offers a route to transform conventional chemical industries into cleaner and more sustainable production.
{"title":"Pulsed electrochemistry for water decontamination: Fundamental principles and environmental application","authors":"Mengjiao Xie , Nadeeshani Nanayakkara , Yanbiao Liu","doi":"10.1016/j.cclet.2025.111669","DOIUrl":"10.1016/j.cclet.2025.111669","url":null,"abstract":"<div><div>Sustainable and efficient solutions are essential to address increasingly critical environmental issues, particularly in the field of pollutant removal and resource recovery. The latest research has shown that pulsed electrochemistry significantly contributes to these goals by precisely altering the local reaction environment, accelerating the reaction kinetics and decreasing the overall energy requirements. However, knowledge gaps exist in dynamic evolution mechanism of electric double layer (EDL) in this technology, and challenges remain toward fully implementation of this promising technology. In this review, the fundamentals of pulsed electrochemistry and its connection to the theoretical models of EDL are comprehensively presented. The critical parameters (<em>e.g.</em>, duty ratio, frequency and waveform) for boosting the performance of the system are systematically discussed and the typical electrochemical reactions that occur with pulsed electrochemistry are outlined. The proposed pulsed electrochemistry methodologies tailored for environmental applications are also reviewed in detail. Finally, future opportunities and challenges of this promising but fledgling field are discussed, with the expectation that this technology offers a route to transform conventional chemical industries into cleaner and more sustainable production.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111669"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, the spin-orbit charge transfer intersystem crossing (SOCT-ISC) mechanism is introduced into the near-infrared and highly photon-capturing heptamethine cyanine (Cy7) class to construct photosensitizer (PS) for photodynamic therapy (PDT) of tumor. The target PS ANCy7 shows an obviously improved singlet oxygen (1O2) quantum yield than the Food and Drug Administration (FDA)-approved indocyanine green (ICG) under 750 nm low-power photoirradiation (30 mW/cm2) while retaining strong fluorescence at ∼805 nm. Importantly, the PS forms a 2:1 dye-human serum albumin (HSA) nanocomplex, ensuring its strong accumulation and retention at tumor site (up to five days) post intravenous injection. After a single PDT treatment, the nanocomplex almost completely ablates primary tumor while triggering an antitumor immune response to suppress the growth of distant tumors. Overall, the nanocomplex overcomes many shortcomings of clinically used PSs, thus being promising for future clinical translation.
{"title":"Augmenting heptamethine cyanine photosensitivity while retaining strong fluorescence emission: Forming dye-albumin nanocomplex enables tumor-targeted photodynamic therapy","authors":"Mengxing Liu, Jing Liu, Hongxing Zhang, Lijuan Wang, Jianan Tao, Wei Guo","doi":"10.1016/j.cclet.2025.111141","DOIUrl":"10.1016/j.cclet.2025.111141","url":null,"abstract":"<div><div>In this work, the spin-orbit charge transfer intersystem crossing (SOCT-ISC) mechanism is introduced into the near-infrared and highly photon-capturing heptamethine cyanine (Cy7) class to construct photosensitizer (PS) for photodynamic therapy (PDT) of tumor. The target PS AN<img>Cy7 shows an obviously improved singlet oxygen (<sup>1</sup>O<sub>2</sub>) quantum yield than the Food and Drug Administration (FDA)-approved indocyanine green (ICG) under 750 nm low-power photoirradiation (30 mW/cm<sup>2</sup>) while retaining strong fluorescence at ∼805 nm. Importantly, the PS forms a 2:1 dye-human serum albumin (HSA) nanocomplex, ensuring its strong accumulation and retention at tumor site (up to five days) post intravenous injection. After a single PDT treatment, the nanocomplex almost completely ablates primary tumor while triggering an antitumor immune response to suppress the growth of distant tumors. Overall, the nanocomplex overcomes many shortcomings of clinically used PSs, thus being promising for future clinical translation.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111141"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-03-25DOI: 10.1016/j.cclet.2025.111140
Xiaodan Liang , Tong Tong , Caihong Xian , Jiyuan Du , Biying Tan , Liying Wang , Jingyi Hou , Jun Wu
Bone-related diseases resulting from accidents, illnesses, and injuries have become increasingly common in recent years. Treating these conditions poses significant challenges, including prolonged recovery times, high costs, and unpredictable outcomes, which can lead to complications such as infections and reduced muscle strength. Although autologous bone transplantation is regarded as the "gold standard" for addressing bone diseases, its application is often limited by complications at the donor site and the risk of infection. This underscores the urgent need to explore alternatives to autogenous bone transplantation. In response, a range of biomaterials for bone repair have been developed, with metal-based biomaterials emerging as effective adjuncts that enhance and optimize the repair and regeneration of bone tissue. These materials can actively influence the bone repair process through mechanisms such as inductive osteogenesis, immunomodulation, and pro-angiogenesis. This review begins by highlighting the biological effects of metal-based biomaterials, followed by a comprehensive overview of their macro- and micro-scale classifications and applications for treating various bone diseases. Finally, the review addresses future directions and challenges associated with the use of metal-based biomaterials in bone repair, aiming to propose promising strategies for the treatment of bone-related diseases.
{"title":"Metal-based biomaterials for treating bone diseases","authors":"Xiaodan Liang , Tong Tong , Caihong Xian , Jiyuan Du , Biying Tan , Liying Wang , Jingyi Hou , Jun Wu","doi":"10.1016/j.cclet.2025.111140","DOIUrl":"10.1016/j.cclet.2025.111140","url":null,"abstract":"<div><div>Bone-related diseases resulting from accidents, illnesses, and injuries have become increasingly common in recent years. Treating these conditions poses significant challenges, including prolonged recovery times, high costs, and unpredictable outcomes, which can lead to complications such as infections and reduced muscle strength. Although autologous bone transplantation is regarded as the \"gold standard\" for addressing bone diseases, its application is often limited by complications at the donor site and the risk of infection. This underscores the urgent need to explore alternatives to autogenous bone transplantation. In response, a range of biomaterials for bone repair have been developed, with metal-based biomaterials emerging as effective adjuncts that enhance and optimize the repair and regeneration of bone tissue. These materials can actively influence the bone repair process through mechanisms such as inductive osteogenesis, immunomodulation, and pro-angiogenesis. This review begins by highlighting the biological effects of metal-based biomaterials, followed by a comprehensive overview of their macro- and micro-scale classifications and applications for treating various bone diseases. Finally, the review addresses future directions and challenges associated with the use of metal-based biomaterials in bone repair, aiming to propose promising strategies for the treatment of bone-related diseases.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111140"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-03-07DOI: 10.1016/j.cclet.2025.111047
Haolin Zhang , Kai Feng , Guisen Li, Weijiao Chen, Yuan Shao, Jiayu Ding, Mingming Zheng, Kai Yuan, Xiaolian Sun, Peng Yang
In the process of tumor treatment, chemotherapy drugs have been widely used in clinical practice due to their broad-spectrum and significant therapeutic effects. However, the serious side effects caused by off-target effects also limit the actual efficacy of such drugs in clinical. Here, we developed a series of small molecule-drug conjugates (SMDCs) with carbonic anhydrase IX (CAIX)-targeted unit, which can deliver chemotherapy drugs to CAIX-positive cancer cells and release them in the tumor microenvironment. These SMDCs can quickly captured by the highly expressed CAIX on the tumor membrane, forming a high local concentration difference that allows SMDCs to enter the tumor cells faster. The optimized SMDC (CAIXi-R-HCPT) with ROS-sensitive linker showed higher cytotoxicity than Irinotecan. In MDA-MB-231 solid tumor-bearing mice, CAIXi-R-HCPT showed higher tumor/normal tissue (T/N) ratio than the corresponding SMDC and Irinotecan control and it also exhibited in vivo anti-tumor activity comparable to HCPT at the same dosage, and there was no significant weight loss. These findings emphasize the potential of CAIXi-R-HCPT as a promising anti-cancer SMDC that exhibits targeted delivery, tumor-specific release, and strong anti-tumor effects.
{"title":"Carbonic anhydrase IX-targeted SMDCs for cancer precision treatment","authors":"Haolin Zhang , Kai Feng , Guisen Li, Weijiao Chen, Yuan Shao, Jiayu Ding, Mingming Zheng, Kai Yuan, Xiaolian Sun, Peng Yang","doi":"10.1016/j.cclet.2025.111047","DOIUrl":"10.1016/j.cclet.2025.111047","url":null,"abstract":"<div><div>In the process of tumor treatment, chemotherapy drugs have been widely used in clinical practice due to their broad-spectrum and significant therapeutic effects. However, the serious side effects caused by off-target effects also limit the actual efficacy of such drugs in clinical. Here, we developed a series of small molecule-drug conjugates (SMDCs) with carbonic anhydrase IX (CAIX)-targeted unit, which can deliver chemotherapy drugs to CAIX-positive cancer cells and release them in the tumor microenvironment. These SMDCs can quickly captured by the highly expressed CAIX on the tumor membrane, forming a high local concentration difference that allows SMDCs to enter the tumor cells faster. The optimized SMDC (CAIXi-R-HCPT) with ROS-sensitive linker showed higher cytotoxicity than Irinotecan. In MDA-MB-231 solid tumor-bearing mice, CAIXi-R-HCPT showed higher tumor/normal tissue (T/N) ratio than the corresponding SMDC and Irinotecan control and it also exhibited <em>in vivo</em> anti-tumor activity comparable to HCPT at the same dosage, and there was no significant weight loss. These findings emphasize the potential of CAIXi-R-HCPT as a promising anti-cancer SMDC that exhibits targeted delivery, tumor-specific release, and strong anti-tumor effects.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111047"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-04-11DOI: 10.1016/j.cclet.2025.111200
Jun-Gang Wang , Bing-Yi Zhou , Yao-Luo Hu , Yong-Dong Du , Rong-He Wu , Chun-Yan Wu , Wen-Chao Yang , An-Xin Wu
An efficient skeletal editing for the construction of 2-benzodiazepines from benzo[c]oxepines was developed through atom-swapping of oxygen atom to the nitrogen atom. This reaction integrated the sequential ring-opening/substitution/ring-closing in the continuous manufacturing one-pot synthesis. The reaction conditions are mild, transition metal-free, simple-operated and the substrates are widely applicable. The anti-tumor activity of some synthesized 2-benzodiazepine compounds shows this atom-swapping skeletal editing through the deconstruction-reconstruction of heterocycles is attractive and effective in the discovery of new drug skeletons.
{"title":"Atom-swapping skeletal editing of benzo[c]oxepines for the construction of 2-benzodiazepines via a continuous manufacturing one-pot synthesis","authors":"Jun-Gang Wang , Bing-Yi Zhou , Yao-Luo Hu , Yong-Dong Du , Rong-He Wu , Chun-Yan Wu , Wen-Chao Yang , An-Xin Wu","doi":"10.1016/j.cclet.2025.111200","DOIUrl":"10.1016/j.cclet.2025.111200","url":null,"abstract":"<div><div>An efficient skeletal editing for the construction of 2-benzodiazepines from benzo[<em>c</em>]oxepines was developed through atom-swapping of oxygen atom to the nitrogen atom. This reaction integrated the sequential ring-opening/substitution/ring-closing in the continuous manufacturing one-pot synthesis. The reaction conditions are mild, transition metal-free, simple-operated and the substrates are widely applicable. The anti-tumor activity of some synthesized 2-benzodiazepine compounds shows this atom-swapping skeletal editing through the deconstruction-reconstruction of heterocycles is attractive and effective in the discovery of new drug skeletons.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111200"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-04-02DOI: 10.1016/j.cclet.2025.111167
Chuangchuang Liu , Yilian Song , Wenjie Ju , Xin Liu , Min Liang , Yingsheng Zhao
Amino acids are the building blocks of proteins and various bioactive molecules. Fluorination is a key strategy in medicinal chemistry, making the development of new and efficient methods for fluorinating amino acids highly desirable. While many fluorination reagents have been developed, their application on amino acid frameworks remains limited. In this study, we demonstrate that ethyl 3‑bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate is an effective gem‑difluoroalkenes precursor for constructing a library of monofluoroolefin amino acids via a Pd-catalyzed cross-coupling reaction.
{"title":"A highly efficient approach to Z-monofluoroolefin-dehydroamino acid derivatives from gem-difluoroalkenes","authors":"Chuangchuang Liu , Yilian Song , Wenjie Ju , Xin Liu , Min Liang , Yingsheng Zhao","doi":"10.1016/j.cclet.2025.111167","DOIUrl":"10.1016/j.cclet.2025.111167","url":null,"abstract":"<div><div>Amino acids are the building blocks of proteins and various bioactive molecules. Fluorination is a key strategy in medicinal chemistry, making the development of new and efficient methods for fluorinating amino acids highly desirable. While many fluorination reagents have been developed, their application on amino acid frameworks remains limited. In this study, we demonstrate that ethyl 3‑bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate is an effective <em>gem</em>‑difluoroalkenes precursor for constructing a library of monofluoroolefin amino acids <em>via</em> a Pd-catalyzed cross-coupling reaction.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111167"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-09-24DOI: 10.1016/j.cclet.2025.111881
Xiaotong Deng , Zetao Wu , Anna Zhou , Shuo-Hang Zheng , Ziheng Cheng , Guangming Li , Yun Zhao , Ronghua Zeng , Nguyen Duc Hoa , Xing-Long Wu
Quinone-based electrode materials hold significant promise for next-generation sodium-ion batteries due to their structurally tailorable frameworks, high theoretical capacities, and favorable redox potentials. However, dissolution in organic electrolytes and structural instability during cycling critically impair their capacity retention and cycling durability. Herein, we designed and synthesized two novel acylimide materials N,N'-bis(2,6-anthraquinone diamine)-biphenyl diimide (DQ-BDI) and N,N'-bis(anthraquinone-2,6-diamine)-perylenyl diimide (DQ-PDI) with the gradual enhancement of π-conjugation. Electrochemical characterization reveals exceptional performance in DQ-PDI. At the current density of 50 mA/g, the DQ-PDI delivered the first discharge specific capacity of 158 mAh/g, and the capacity retention of 99 % after 100 cycles, with the coulombic efficiency of nearly 100 %. At a high current density of 500 mA/g, the DQ-PDI displays a high discharge capacity of 152 mAh/g. The reduction peaks of DQ-PDI located at 2.28 V and 1.34 V are the insertion reactions of sodium ion from the carbonyl groups on PTCDA unit and on DAAQ unit at both ends, respectively, and the two oxidation peaks at 2.58 V and 1.53 V corresponds to extraction reactions. Compared with DQ-BDI, DQ-PDI exhibits a larger π-conjugation plane, which significantly enhances the intermolecular π-π interactions. It can well reduce the dissolution of the material in organic electrolyte, resulting in a higher discharge capacity, superior cycling stability and accelerated reaction kinetics. Our π-conjugation extension strategy establishes a new paradigm for designing dissolution-resistant, high-performance organic electrodes.
{"title":"Enhanced electrochemical performance of anthraquinone-based cathode for sodium ion batteries by π-conjugated structure","authors":"Xiaotong Deng , Zetao Wu , Anna Zhou , Shuo-Hang Zheng , Ziheng Cheng , Guangming Li , Yun Zhao , Ronghua Zeng , Nguyen Duc Hoa , Xing-Long Wu","doi":"10.1016/j.cclet.2025.111881","DOIUrl":"10.1016/j.cclet.2025.111881","url":null,"abstract":"<div><div>Quinone-based electrode materials hold significant promise for next-generation sodium-ion batteries due to their structurally tailorable frameworks, high theoretical capacities, and favorable redox potentials. However, dissolution in organic electrolytes and structural instability during cycling critically impair their capacity retention and cycling durability. Herein, we designed and synthesized two novel acylimide materials <em>N,N</em>'-bis(2,6-anthraquinone diamine)-biphenyl diimide (DQ-BDI) and <em>N,N</em>'-bis(anthraquinone-2,6-diamine)-perylenyl diimide (DQ-PDI) with the gradual enhancement of <em>π</em>-conjugation. Electrochemical characterization reveals exceptional performance in DQ-PDI. At the current density of 50 mA/g, the DQ-PDI delivered the first discharge specific capacity of 158 mAh/g, and the capacity retention of 99 % after 100 cycles, with the coulombic efficiency of nearly 100 %. At a high current density of 500 mA/g, the DQ-PDI displays a high discharge capacity of 152 mAh/g. The reduction peaks of DQ-PDI located at 2.28 V and 1.34 V are the insertion reactions of sodium ion from the carbonyl groups on PTCDA unit and on DAAQ unit at both ends, respectively, and the two oxidation peaks at 2.58 V and 1.53 V corresponds to extraction reactions. Compared with DQ-BDI, DQ-PDI exhibits a larger <em>π</em>-conjugation plane, which significantly enhances the intermolecular <em>π</em>-<em>π</em> interactions. It can well reduce the dissolution of the material in organic electrolyte, resulting in a higher discharge capacity, superior cycling stability and accelerated reaction kinetics. Our <em>π</em>-conjugation extension strategy establishes a new paradigm for designing dissolution-resistant, high-performance organic electrodes.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111881"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zinc ion hybrid capacitors (ZIHCs) are emerging electrochemical energy storage devices with the dual characteristics of high energy density and high power density. However, the mismatch of capacity and electrode kinetics between porous carbon cathodes and zinc metal anodes limits the development of ZIHCs. Lignin has high carbon content, high aromaticity, and three-dimensional functional molecular structures, which is an ideal raw material for preparing high-performance porous carbon electrode materials with high carbon yield, conductive carbon network and enriched heteroatom dopants. Currently, the high-value utilization ratio of industrial lignin is lower than 10%. In this review, the typical preparation methodologies of lignin-derived porous carbons are summarized. The latest research advances for the lignin-derived porous carbon cathodes in ZIHCs are critically focused from the perspectives of pore regulation, surface modification, and morphology design. The core points and development directions that lignin-derived porous carbon cathodes are expected to achieve an original breakthrough in the future are proposed from three levels of techniques, mechanisms, and applications. This review fills the blank region in the applications of lignin-derived porous carbons for ZIHCs, aiming to provide valuable guidance for the high-value utilization process of lignin and the industrialization process of ZIHCs.
{"title":"Lignin valorization towards porous carbon cathodes in zinc ion hybrid capacitors","authors":"Caiwei Wang , Cheng Zeng , Changhong Wei , Guizhen Chen , Yueling Liang , Wenli Zhang","doi":"10.1016/j.cclet.2025.111850","DOIUrl":"10.1016/j.cclet.2025.111850","url":null,"abstract":"<div><div>Zinc ion hybrid capacitors (ZIHCs) are emerging electrochemical energy storage devices with the dual characteristics of high energy density and high power density. However, the mismatch of capacity and electrode kinetics between porous carbon cathodes and zinc metal anodes limits the development of ZIHCs. Lignin has high carbon content, high aromaticity, and three-dimensional functional molecular structures, which is an ideal raw material for preparing high-performance porous carbon electrode materials with high carbon yield, conductive carbon network and enriched heteroatom dopants. Currently, the high-value utilization ratio of industrial lignin is lower than 10%. In this review, the typical preparation methodologies of lignin-derived porous carbons are summarized. The latest research advances for the lignin-derived porous carbon cathodes in ZIHCs are critically focused from the perspectives of pore regulation, surface modification, and morphology design. The core points and development directions that lignin-derived porous carbon cathodes are expected to achieve an original breakthrough in the future are proposed from three levels of techniques, mechanisms, and applications. This review fills the blank region in the applications of lignin-derived porous carbons for ZIHCs, aiming to provide valuable guidance for the high-value utilization process of lignin and the industrialization process of ZIHCs.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111850"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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