Oral Oncology Extra最新文献

Human papilloma virus (HPV) is the most common sexually transmitted viral disease responsible for mucosal warts and anogenital malignancies. HPV-associated oral lesions include condyloma, focal epithelial hyperplasia and some squamous cell carcinomas. Recent studies have shown an increased risk of oral warts in HIV positive individuals. This article, reports an unusual presentation of a disseminated oral HPV infection in a newly diagnosed HIV positive patient after the initiation of highly active antiretrovirals therapy (HAART).

Carcinosarcoma is a rare salivary gland neoplasm consisting of both carcinomatous and sarcomatous component. It may arises de novo or on a pre-existing pleomorphic adenoma. We present a case of parotid carcinosarcoma, exhibiting features of salivary ductal adenocarcinoma (carcinomatous element) and fibrosarcoma/osteosarcoma (sarcomatous element). Immunohistochemical analysis with Ki67, p53, p27, C-KIT, bcl2, cerbB2, SMA, VIM has performed and cell adhesion molecules’ expression, E-cadherin, beta4-integrin, desmoglein-2, CD44s and ICAM-1 has been detected. In conclusion carcinosarcoma is an aggressive tumor, with a biphasic malignant neoplastic component showing characteristic immunohistochemical profile and reduced or extremely alternative CAMs expression.

The cribriform-morular variant (C-MV), an unusual and peculiar subtype of papillary thyroid carcinoma, has been observed frequently in familial adenomatous polyposis (FAP)-associated thyroid carcinoma and also in sporadic thyroid carcinoma. Here we present a case of similar unusual sporadic thyroid tumour, which presented with cervical lymph node metastasis.

The authors presented a second reported case of dedifferentiated liposarcoma of the pyriform sinus in a 50-year old male, with a history of heavy smoking, airway obstruction and dysphagia. A computed tomography (CT) of the neck and thorax revealed a retroesophageal lobulated heterogenous mass. A laryngoscopic examination disclosed sessile polypoid mass in the right pyriform sinus. Microscopically, the neoplasm consisted of areas of well-differentiated liposarcoma and a non-lipogenic component (dedifferentiated component). These two parts were co-mingled, giving a mosaic pattern. Well-differentiated liposarcoma was characterized by adipocytes with a great variation in size, and multivacuolated lipoblasts. Immunohistochemical studies showed positive reactivity with vimentin and smooth muscle actin in non-lipogenic component. This neoplasm shows histological and immunohistochemical features of dedifferentiated liposarcoma with myogenic differentiation.

The increases incidence of oral human papillomavirus (HPV) in patients infected with the human immunodeficiency virus (HIV) is of concern and is the focus of numerous current research studies. Recent studies have shown an increased risk of oral warts in HIV-infected individuals despite treatment with highly active antiretroviral therapy (HAART). There seems to be a predilection for the labial mucosa as a site specific for occurrence for oral warts. This reports presents a series of case reports documenting the same observation.

Carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma usually occurring in the lower extremity. Occurrence in the oral cavity is unusual and was reported in the literature less than 20 times. A 81 year old female presented with pain in the left mandible. Clinical examination showed no pathologic result but panoramic radiograph showed osteolytic lesion. Result of histological study was CC and local resection was done. Eight month later patient presented again with pain in the contralateral side of the mandible and follow up X-ray showed a new osteolytic lesion. Histology confirmed second occurrence of CC. CC is rare entity especially in the head and neck showing local aggressive behavior but should be considered as differential diagnosis.

Necrotizing sialometaplasia is an uncommon inflammatory condition that affects salivary glands. A 38-year-old man with bilateral ulcerative painful lesions at the junction of the hard and soft palate was presented. An incisional biopsy was performed. Histopathologically, pseudoepithelomatous hyperplasia, lobular necrosis with through the maintenance of the architecture of salivary glands and squamous metaplasia of residual acinar and ductal elements with a bland appearance were observed. The complete self-healing of the lesions occurred in 3 weeks. Since this entity presents clinical and histopathological findings resembling either mucoepidermoid carcinoma or squamous carcinoma diagnostic failure may culminate in unnecessary mutilating surgery.

Malignant tumors of the nasal cavity and paranasal sinuses are rare, with poorly differentiated squamous cell carcinoma of the maxillary sinus being the most common. The aim of this study is to report a carcinoma affecting the maxillary sinus of a young adult, with diagnosis only being achieved with an intra-oral biopsy, after the lesion had perforated the palate bone. This case stresses the importance of early diagnosis of maxillary sinus carcinoma, in order to increase chances of survival.

Ameloblastic fibro-odontoma is a benign epithelial odontogenic tumor with odontogenic mesenchyme exhibiting a histologic characteristics of ameloblastic fibroma and odontoma. It is slow-growing, and usually is small. We present a huge ameloblastic fibro-odontoma in the maxilla of a 17 year-old woman.

The findings of a computed tomography (CT) and magnetic resonance (MR) are reported in this study for a odontogenic myxoma arising in the maxilla of a 22 years-old Brazilian woman. The CT showed an expansive formation of circular aspect located in the alveolar process of the left maxilla with slight heterogeneous distinction after iodinized contrast. Unilateral crowding with displacement of some dental elements inside the lesion was shown in the MR and CT images. The MR images showed a well-defined and smooth-walled mass lesion with low signal intensity on T1-weighted images and high-signal intensity on T2-weighted images. The treatment of choice was a surgical tumoral resection and three applications of cryotherapheutic agent for 1 min in the same surgical time with interval of 5 min between them.