Oral Oncology Extra最新文献

Two cases (intraosseous and extraosseous lesion, respectively) of rare calcifying epithelial odontogenic tumors with Langerhans cells were reported. The tumors were examined by HE, PAS and Congo red staining, ultrastructural and immunohistochemical observation for Langerhans cells labeling antibodies (CD1a, CD68 , HLA-DR and S-100). The tumours chiefly consisted of small nests (cords) of epithelial cells, homogenous material and scarce calcification and few epithelial cells showed positive for these specific antibodies. Ultrastructural studies found Langerhans cells with Birbeck’s granules among tumor cells. Ultrastructural analysis and positive immunoreactivities suggested the two cases be Langerhans cells containing calcifying epithelial odontogenic tumors.

Pleomorphic adenoma of a buccal or molar minor salivary gland, which lies on the external aspect of buccinator, has not been reported previously. We report a case of a pleomorphic adenoma apparently arising from such a gland. Histologically there was marked cystic degeneration producing an apparently empty lumen surrounded by an encapsulated cellular mass. While the final diagnosis was pleomorphic adenoma, there were a number of features of myoepithelioma and the differences between these entities are discussed.

Parotid gland is an extremely rare location for primary malignant melanoma and the majority of reported melanoma cases in parotid appear to represent metastasis from the skin of head and neck areas. We describe a rare case of a malignant melanoma of the oral cavity which had metastasized in parotid gland and we present the microscopic and immunohistochemical findings in parotid gland metastasis. Metastatic infiltrations were observed in peri- and intraparotid lymph nodes and the characteristic microscopic appearance together with the immunoreactivity of neoplastic cells for vimentin, S-100 protein and HMB-45 established the final diagnosis.

Brown tumour is a non-neoplastic lesion resulting from abnormal bone metabolism in hyperparathyroidism. We describe a rare case of peripheral brown tumour associate with secondary hyperparathyroidism simulating a peripheral giant cell lesion of the jaws.

Malignant fibrous histiocytoma (MFH) of the maxilla is a rare neoplasm. A round 61 cases reported in the international literature since 1974. We present a rare case of primary MFH of the maxilla in the unusual location of maxilla in a 64-year-old man. The tumor was located in the left tuberosity of maxilla extending from the junction between soft and hard palate towards premolar area of edentulous ridge, and measured 7 cm × 6 cm. Histologically, it consisted of spindle-shaped, pleomorphic malignant cells in a storiform pattern associated with histiocyte-like cells and giant cells. Mitotic figures were frequent Immunohistochemically, most of the tumor cells were strongly positive for vimentin, and negative with S-100 protein, cytokeratin, actin, desmin, HMB45 and epithelial membrane antigen. Ultra structurally, the tumor have clearly shown spindle shaped fibroblastic and giant cells with well-known pleomorphic multi-segmented nuclei, prominent branching and often dilated rough endoplasmic reticulum (RER). Histopathological and ultra structural findings are consistent with high-grade MFH of the storiform/pleomorphic subtype. Four months later the patient came with residual/recurrent tumor that was confirmed histopathologically. The literature is briefly reviewed.

Oral granular cell tumour is a rare soft tissue tumour of mesenchymal origin. The most frequently affected site in the oral cavity is the tongue, followed by the floor of mouth, and buccal mucosa. In paediatric patients, 25% of cases have been reported to occur in the lip, but this presentation in adults is extremely rare. We report a case of oral granular cell tumour in a 35 year-old female, located in the lower lip. Histopathological examination revealed eosinophilic granular cells which stained positively for S-100 protein; a finding supportive of a neural origin. A history of trauma was elicited in this case, and the lesion was treated with surgical excision.

Metastatic tumor of the jawbone is rare, with condyle location being rarer. Primary tumors that most commonly metastasize to the mouth are: breast, lung and kidney. Jawbone metastases appear as a result of distant disease spreading and show poor prognosis, with short survival. Here we present a 46-year-old woman with metastatic breast adenocarcinoma that involved left condyle, which caused pathological fracture. Numbness of the left chin and lower lip, pain and open limiting progressively appeared. It has been 4 years since the condyle metastasis was found. The common symptoms, diagnosis and treatment of jawbone metastasis are discussed in the paper.