Revista Colombiana de Reumatología (English Edition)最新文献

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Detection of latent tuberculosis by tuberculin booster in patients with immunosuppressive treatment 应用结核菌素增强剂检测免疫抑制患者的潜伏性结核

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01 DOI: 10.1016/j.rcreue.2025.02.001

Luis Javier Cajas , María Carolina Torres , Mayelin Fernanda Ceballos

Introduction and objective

One-third of the world's population has latent tuberculosis. Because it can be reactivated by immunosuppressive treatments, screening is suggested. In Colombia, the tuberculin test with the booster is recommended in this population because of the risk of false negative results and anergy caused by treatments. Currently, the number of patients detected with this second test is unknown, so the primary objective is to determine the percentage of additional positive detections.

Materials and methods

From 2017 to 2022, a cross-sectional, analytical study was conducted on a group of patients from a rheumatology service who had a tuberculin test and a booster within a year to check for latent tuberculosis. Over the course of a year and three weeks, we looked at the number of patients whose booster tests showed new findings. A study was conducted to see if there were any differences in treatment based on the first tuberculin result.

Results

A tuberculin test was performed on 674 subjects, of whom 496 were immunosuppressed. From the 382 whose test was negative, 191 and 74 booster tests were performed within a year and three weeks; 8 (4.1%) and 3 (3.6%) were positive, respectively. When evaluating the differences in treatments between the groups with a positive and negative first tuberculin test, significant differences were found. Use of prednisolone at 5 mg or more per day (p = .02) and three immunosuppressants (p = .005) was more frequent in negative tuberculin tests.

Conclusions

It can be said that the booster test raises the number of people with latent tuberculosis by 4%. More use of prednisolone at 5 mg/day or three immunosuppressants in the group with the negative tuberculin test was found to be statistically significant.

前言和目的世界上三分之一的人口患有潜伏性结核病。由于它可以通过免疫抑制治疗重新激活，建议进行筛查。在哥伦比亚，由于存在假阴性结果的风险和治疗引起的精力不足，建议在这一人群中进行结核菌素增强试验。目前，用第二种检测方法检测出的患者数量未知，因此主要目标是确定额外阳性检测的百分比。材料和方法从2017年到2022年，对风湿病服务的一组患者进行了横断面分析研究，这些患者在一年内进行了结核菌素试验和增强剂，以检查潜伏性结核病。在一年零三周的时间里，我们观察了加强测试显示出新发现的患者数量。研究人员进行了一项研究，以观察基于第一次结核菌素结果的治疗是否有任何差异。结果674例患者行结核菌素试验，免疫抑制者496例。在382名检测结果为阴性的人中，191名和74名在一年零三周内进行了加强检测；阳性8例（4.1%），阳性3例（3.6%）。当评估首次结核菌素试验阳性和阴性组之间的治疗差异时，发现显着差异。在结核菌素试验阴性的患者中，每天使用5mg或更多的强的松龙（p = 0.02）和三种免疫抑制剂（p = 0.005）更为常见。结论强化试验可使潜伏性肺结核的发病人数增加4%。在结核菌素试验阴性的组中，更多地使用5mg /天的强的松龙或三种免疫抑制剂被发现具有统计学意义。

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引用次数: 0

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01

引用次数: 0

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01

引用次数: 0

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01

引用次数: 0

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01

引用次数: 0

Investigation of motor skill in patients with juvenile idiopathic arthritis: A cross sectional study 青少年特发性关节炎患者运动技能的调查：一项横断面研究

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01 DOI: 10.1016/j.rcreue.2025.02.003

Sinem Yenil , Elif Gur Kabul , Bilge Basakci Calik , Gulsah Kilbas , Selcuk Yuksel

Introduction

The inflammatory process of Juvenile Idiopathic Arthritis (JIA) is associated comorbidities. The JIA patients can fall behind their healthy peers, and motor and functional skills can reduce.

Objectives

The primary aim is to compare the motor skills of JIA patients with healthy controls. The secondary aim is to determine whether disease activity affects patients with JIA.

Materials and methods

Fifteen patients with JIA and 15 healthy controls were included in the study. Motor skills were evaluated with Bruininks-Oseretsky Test of Motor Proficiency Second Edition Short Form (BOT-2 SF) in patients with JIA and healthy controls. BOT-2 SF measures four motor area composites with eight subtests. Disease activity was evaluated with Juvenile Arthritis Disease Activity Score-27 (JADAS-27), disability level with Childhood Health Assessment Questionnaire Disability Index (CHAQ-DI), and disease-related quality of life with Pediatric Quality of Life Inventory (PedsQL) 3.0 Arthritis Module for JIA. According to disease activity, patients with JIA were divided into two groups as remission and active.

Results

The patients with JIA had significantly lower scores in the total and four motor area of BOT-2 SF compared to healthy controls (p < .05). When the remission and active groups were compared, there was no difference in the total and four motor area of BOT-2 SF, CHAQ-DI, or PedsQL (p > .05).

Conclusion

The motor skills of patients with JIA are lower than their healthy peers, and their motor skills, quality of life, and disability did not make a difference between the remission and active period.

青少年特发性关节炎（JIA）的炎症过程是相关的合并症。JIA患者可以落后于他们的健康同龄人，运动和功能技能可以降低。目的比较JIA患者与健康对照者的运动技能。次要目的是确定疾病活动是否影响JIA患者。材料与方法选择JIA患者15例，健康对照15例。采用Bruininks-Oseretsky运动能力测试第二版简表（BOT-2 SF）对JIA患者和健康对照者的运动技能进行评估。BOT-2 SF测量四个运动区域复合材料，包括八个子测试。采用青少年关节炎疾病活动性评分-27 （JADAS-27）评估疾病活动性，采用儿童健康评估问卷残疾指数（CHAQ-DI）评估残疾水平，采用儿童生活质量量表（PedsQL） 3.0关节炎模块评估JIA的疾病相关生活质量。根据病情活动度将JIA患者分为缓解组和活动期两组。结果JIA患者在BOT-2 SF总分和4个运动区得分均显著低于健康对照组(p <；. 05)。缓解组与活跃组比较，BOT-2 SF、CHAQ-DI、PedsQL的总运动面积和四运动面积无差异(p >；. 05)。结论JIA患者的运动技能低于健康同龄人，缓解期和活动期患者的运动技能、生活质量和残疾程度无显著差异。

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Histological findings and complications in patients with salivary gland biopsy in two institutions of Medellín, Colombia a descriptive study 在哥伦比亚Medellín的两家机构对患者涎腺活检的组织学发现和并发症进行了一项描述性研究

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-01-01 DOI: 10.1016/j.rcreue.2024.11.001

Luz Adriana Gómez-Ramírez , Laura Betancur-Gómez , Estefanía Tabares-Ramírez , Sofía Villada-Montoya , Libia María Rodríguez-Padilla , María Fernanda Álvarez-Barreneche , Carlos Jaime Velásquez-Franco , Miguel Antonio Mesa-Navas , Marcela Posada-Velásquez

Introduction

Salivary gland biopsy is the gold standard for the diagnosis of Sjogren’s syndrome. There are several approaches for the realization of the biopsy, being generally used an approach to the mucosa with the use of various instruments and incisions that vary in length, passing through trucut biopsy to scraping with needle.

Materials and methods

We conducted a descriptive study that included adult patients undergoing salivary gland biopsy between 2017 and 2022. Medical records and salivary gland biopsy reports were used to collect information and registered in the Magpi platform. Sociodemographic, clinical, and histopathological variables were recorded. The qualitative variables were expressed in absolute and relative frequencies; the quantitative ones were by median and interquartile range. Seventy-two biopsies were included.

Results

Regarding demographic characteristics, 87,5% were women with a median age of 52 years. The biopsy characteristics showed that 70 (97,2%) corresponded to a representative sample. Twenty-seven (38,5%) biopsies showed lymphocytic infiltration and reported a classification system, of which the most used one was the Chisholm Mason used in 18 (66,6%) of such biopsies. Complications were present in four (5,7%) patients.

Conclusions

Despite the recommendation of using Focus Score for classification criteria, the Chisholm Mason system is still the most widely used. The present technique is a safe and effective for the realization of minor salivary gland biopsy.

涎腺活检是诊断干燥综合征的金标准。实现活检的方法有几种，一般采用粘膜活检方法，使用各种器械和不同长度的切口，通过组织活检到用针刮拭。材料和方法我们进行了一项描述性研究，纳入了2017年至2022年间接受唾液腺活检的成年患者。使用医疗记录和唾液腺活检报告收集信息并在Magpi平台中注册。记录社会人口学、临床和组织病理学变量。定性变量以绝对频率和相对频率表示；定量分析采用中位数和四分位数范围。包括72例活组织检查。结果在人口统计学特征方面，87.5%为女性，中位年龄52岁。活检特征显示70例（97.2%）符合代表性样本。27例（38.5%）活检显示淋巴细胞浸润，并报告了分类系统，其中使用最多的是18例（66.6%）活检使用的Chisholm Mason。4例（5.7%）患者出现并发症。结论尽管推荐使用Focus Score作为分类标准，但Chisholm Mason系统仍然是使用最广泛的。本技术是实现小唾液腺活检的一种安全有效的方法。

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Revista Colombiana de Reumatología (English Edition)

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