Pub Date : 2019-10-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.10.017
Lingyun Ma, A. Rong
Refractory macular edema is a common manifestation of a variety of eye diseases, and it is one of the important causes of impaired vision in patients. The pathogenesis of macular edema is unclear, mainly related to the destruction of the retinal barrier, the expression of inflammatory factors, and the increase of vascular endothelial growth factor. Refractory macular edema is a recurrent disease, which has no response to drugs, seriously affecting vision. The main current clinical treatment is intravitreal anti-vascular endothelial growth factor injection. But for some of the patients who are insensitive to this treatment, intravitreal glucocorticoids injection is performed, but glucocorticoids have the risk of causing elevated intraocular pressure, so the safety of intravitreal glucocorticoids implant needs further study. Appropriate application of retinal laser photocoagulation can reduce the incidence of refractory macular edema, and help resolving the macular edema in some patients. Vitrectomy combined with internal limiting membrane peeling can relieve the tangential stress on the surface of macular and help to eliminate edema, but the surgical mechanical damage to the retina may not be beneficial to vision improvement. On the clinic, patients receive customize individualized treatment according to the pathogenesis, and if necessary, choose combined treatment to eliminate edema as soon as possible to avoid irreversible visual impairment. Key words: Edema, macular, refractory; Anti-vascular endothelial growth factor; Vitrectomy
{"title":"Progress of the treatment of refractory macular edema","authors":"Lingyun Ma, A. Rong","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.10.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.10.017","url":null,"abstract":"Refractory macular edema is a common manifestation of a variety of eye diseases, and it is one of the important causes of impaired vision in patients. The pathogenesis of macular edema is unclear, mainly related to the destruction of the retinal barrier, the expression of inflammatory factors, and the increase of vascular endothelial growth factor. Refractory macular edema is a recurrent disease, which has no response to drugs, seriously affecting vision. The main current clinical treatment is intravitreal anti-vascular endothelial growth factor injection. But for some of the patients who are insensitive to this treatment, intravitreal glucocorticoids injection is performed, but glucocorticoids have the risk of causing elevated intraocular pressure, so the safety of intravitreal glucocorticoids implant needs further study. Appropriate application of retinal laser photocoagulation can reduce the incidence of refractory macular edema, and help resolving the macular edema in some patients. Vitrectomy combined with internal limiting membrane peeling can relieve the tangential stress on the surface of macular and help to eliminate edema, but the surgical mechanical damage to the retina may not be beneficial to vision improvement. On the clinic, patients receive customize individualized treatment according to the pathogenesis, and if necessary, choose combined treatment to eliminate edema as soon as possible to avoid irreversible visual impairment. \u0000 \u0000Key words: \u0000Edema, macular, refractory; Anti-vascular endothelial growth factor; Vitrectomy","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81278651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.10.002
W. Bo, A. Xuemei, Wang Huaizhou
Objective To evaluate the efficacy of microcatheter-assisted trabeculotomy for the treatment of juvenile open angle glaucoma(JOAG). Methods Retrospective case cohort series study. Clinical datas of 20 eyes of 15 cases with JOAG treated with microcatheter-assisted trabeculotomy from Apr.2017 to May 2018 at Eye Hospital Affiliated to Chengdu University of T. C.M. were collected and analysed. Results The pre-operative IOP was (33.55±10.73) mmHg (1 mmHg=0.133 kPa). The post-operative IOP decreased to(15.55±3.88)mmHg at last follow-up, and the difference was statistically significant between before and after surgery (t=9.320, P=0.000). The kinds of anti-glaucoma drugs used before surgery were 3.25±0.55 and at the last follow-up decreased to 0.80±1.32 (Z=-3.750, P=0.001). The full success rate of the last follow-up was 70.00 %(14/20) and conditional success rate was 90.00%(18/20). No severe complication occurred intraoperative and psotoperative. Conclusion Microcatheter-assisted trabeculotomy is a safe and effective for the treatment of JOAG. Key words: Glaucoma, open angle, juvenile; Trabeculotomy, microcatheter-assisted; Pressure, intraocular
{"title":"Microcatheter-assisted trabeculotomy for the treatment of juvenile open angle glaucoma","authors":"W. Bo, A. Xuemei, Wang Huaizhou","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.10.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.10.002","url":null,"abstract":"Objective \u0000To evaluate the efficacy of microcatheter-assisted trabeculotomy for the treatment of juvenile open angle glaucoma(JOAG). \u0000 \u0000 \u0000Methods \u0000Retrospective case cohort series study. Clinical datas of 20 eyes of 15 cases with JOAG treated with microcatheter-assisted trabeculotomy from Apr.2017 to May 2018 at Eye Hospital Affiliated to Chengdu University of T. C.M. were collected and analysed. \u0000 \u0000 \u0000Results \u0000The pre-operative IOP was (33.55±10.73) mmHg (1 mmHg=0.133 kPa). The post-operative IOP decreased to(15.55±3.88)mmHg at last follow-up, and the difference was statistically significant between before and after surgery (t=9.320, P=0.000). The kinds of anti-glaucoma drugs used before surgery were 3.25±0.55 and at the last follow-up decreased to 0.80±1.32 (Z=-3.750, P=0.001). The full success rate of the last follow-up was 70.00 %(14/20) and conditional success rate was 90.00%(18/20). No severe complication occurred intraoperative and psotoperative. \u0000 \u0000 \u0000Conclusion \u0000Microcatheter-assisted trabeculotomy is a safe and effective for the treatment of JOAG. \u0000 \u0000 \u0000Key words: \u0000Glaucoma, open angle, juvenile; Trabeculotomy, microcatheter-assisted; Pressure, intraocular","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84206604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.10.015
Y. Ying, Yu Zhang
Objective To evaluate the efficacy of external application Ichthammol ointment for the treatment of hordeolum. Methods This is a prospective randomized controlled study.The data of 1 430 eyes of 1 430 patients with hordeolum from Jan. 2018 to Dec. 2018 were collected and analyzed.All cases were divided into two groups according to the random number table, with 715 eyes of 715 cases in each group.The clinical trial group applied with conventional treatment and external application of Ichthammol ointment. And the control group applied with conventional treatment.The efficacy of treatment of two groups were observed. Results The patients satisfaction of the trial group was 91.47%(654/715), and 87.69%(627/715) of the control group(χ2=5.462, P=0.019). The effective rate was 83.36%(596/715) in the trial group and 60.42% (432/715)in the control group (χ2=93.069, P=0.000). The recovery time of the trial group was (5.4±2.9)days, and (8.2±4.6)days of the control group. The differences were statistically significant(t=13.47, P=0.003). Conclusion The external application of Ichthammol ointment can significantly reduce the inflammation and edema of hordeolum, and promote recovery. Key words: Hordeolum; Ointment, Ichthammol; Application external; Efficacy
{"title":"Observation on the efficacy of external application of Ichthammol ointment for the treatment of hordeolum","authors":"Y. Ying, Yu Zhang","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.10.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.10.015","url":null,"abstract":"Objective \u0000To evaluate the efficacy of external application Ichthammol ointment for the treatment of hordeolum. \u0000 \u0000 \u0000Methods \u0000This is a prospective randomized controlled study.The data of 1 430 eyes of 1 430 patients with hordeolum from Jan. 2018 to Dec. 2018 were collected and analyzed.All cases were divided into two groups according to the random number table, with 715 eyes of 715 cases in each group.The clinical trial group applied with conventional treatment and external application of Ichthammol ointment. And the control group applied with conventional treatment.The efficacy of treatment of two groups were observed. \u0000 \u0000 \u0000Results \u0000The patients satisfaction of the trial group was 91.47%(654/715), and 87.69%(627/715) of the control group(χ2=5.462, P=0.019). The effective rate was 83.36%(596/715) in the trial group and 60.42% (432/715)in the control group (χ2=93.069, P=0.000). The recovery time of the trial group was (5.4±2.9)days, and (8.2±4.6)days of the control group. The differences were statistically significant(t=13.47, P=0.003). \u0000 \u0000 \u0000Conclusion \u0000The external application of Ichthammol ointment can significantly reduce the inflammation and edema of hordeolum, and promote recovery. \u0000 \u0000 \u0000Key words: \u0000Hordeolum; Ointment, Ichthammol; Application external; Efficacy","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79336984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.011
X. Xiang, Zhengru Huang
Objective To observe the efficacy of intravitreal injection of conbercept in the treatment of macular edema secondary to branch retinal vein occlusion. Methods The data of 33 eyes of 33 patients with macular edema secondary to retinal branch vein occlusion (BRVO-ME) from Jan.2018 to Dec.2018 were retrospectively analysed. The followed-up time was 3 months. Results BCVA(logMAR) were improved at 1, 2, and 3 months after injection, and the difference were statistically significant between before and each time after injection(Z=4.948, 4.642, 4.305, P=0.000, 0.000, 0.000). Central macular retinal thickness (CMT) decreased at 1, 2, and 3 months after injection, and the difference were statistically significant(Z=4.315, 4.404, 4.387, P=0.000, 0.000, 0.000). Conclusion Intravitreal injection of conbercept can improve vision and reduce macular edema in the treatment of retinal branch vein occlusion secondary to macular edema in a short period of time. Key words: Occlusion, vein, retinal; Edema, macular; Conbercept, injection, intravitreal
{"title":"Clinical observation on the efficacy of intravitreal injection of conbercept in the treatment of macular edema","authors":"X. Xiang, Zhengru Huang","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.011","url":null,"abstract":"Objective \u0000To observe the efficacy of intravitreal injection of conbercept in the treatment of macular edema secondary to branch retinal vein occlusion. \u0000 \u0000 \u0000Methods \u0000The data of 33 eyes of 33 patients with macular edema secondary to retinal branch vein occlusion (BRVO-ME) from Jan.2018 to Dec.2018 were retrospectively analysed. The followed-up time was 3 months. \u0000 \u0000 \u0000Results \u0000BCVA(logMAR) were improved at 1, 2, and 3 months after injection, and the difference were statistically significant between before and each time after injection(Z=4.948, 4.642, 4.305, P=0.000, 0.000, 0.000). Central macular retinal thickness (CMT) decreased at 1, 2, and 3 months after injection, and the difference were statistically significant(Z=4.315, 4.404, 4.387, P=0.000, 0.000, 0.000). \u0000 \u0000 \u0000Conclusion \u0000Intravitreal injection of conbercept can improve vision and reduce macular edema in the treatment of retinal branch vein occlusion secondary to macular edema in a short period of time. \u0000 \u0000 \u0000Key words: \u0000Occlusion, vein, retinal; Edema, macular; Conbercept, injection, intravitreal","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75093653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.003
X. Xiao
Objective To evaluate the clinical application of the ellipsoidal eye model in reconstruction of conjunctival sac. Methods Clinical data of 11 eyes of 11 patients with grade Ⅲ-Ⅳ conjunctival sac stenosis from Jun. 2015 to Jun. 2017 were analyzed retrospectively. These patients were treated with the reconstruction conjunctival sac with the ellipsoidal eye model. After 6 months, all cases received secondary incision and separation of conjunctival sac, they wore artificial eyes after healing of eyelid margin. The followed-up time was 3-6 months, and the size, shape and color of conjunctival sac were observed. Results All the transplanted tissues were survived.The shape of conjunctival sac was good in 10 patients, satisfactory appearance after wearing artificial eye. The improved rate was 90.9%. Conclusion Application of ellipsoidal eye model in reconstruction of conjunctival sac is effective. Key words: Model, eye, ellipsoid; Reconstruction, conjunctival sac
{"title":"Application of the ellipsoidal eye model in reconstruction of conjunctival sac","authors":"X. Xiao","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.003","url":null,"abstract":"Objective \u0000To evaluate the clinical application of the ellipsoidal eye model in reconstruction of conjunctival sac. \u0000 \u0000 \u0000Methods \u0000Clinical data of 11 eyes of 11 patients with grade Ⅲ-Ⅳ conjunctival sac stenosis from Jun. 2015 to Jun. 2017 were analyzed retrospectively. These patients were treated with the reconstruction conjunctival sac with the ellipsoidal eye model. After 6 months, all cases received secondary incision and separation of conjunctival sac, they wore artificial eyes after healing of eyelid margin. The followed-up time was 3-6 months, and the size, shape and color of conjunctival sac were observed. \u0000 \u0000 \u0000Results \u0000All the transplanted tissues were survived.The shape of conjunctival sac was good in 10 patients, satisfactory appearance after wearing artificial eye. The improved rate was 90.9%. \u0000 \u0000 \u0000Conclusion \u0000Application of ellipsoidal eye model in reconstruction of conjunctival sac is effective. \u0000 \u0000 \u0000Key words: \u0000Model, eye, ellipsoid; Reconstruction, conjunctival sac","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85846119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.004
Jiu Xudong, Li Wenjie
Objective To analyze the one-stage surgical repair method and clinical efficacy for the treatment of full thickness injuries multiple of eyelid. Methods The data of 92 eyes of 92 cases with multiple injuries of eyelid full thickness from Jan.2015 to Dec.2015 were analyzed retrospectively. The lacerated wound of eyelid full thickness was repaired with three stitch suture, horizontal and vertical mattress suture. Patients who were accompanied with lacrimal canalicular rupture, musculus levator palpebrae superioris fracture and ligament fracture were separately adopted lacrimal canalicular anastomosis, eyelid defect repair and ligament reduction. Results All cases successfully performed emergency surgery repair, no demonstrated wound infection occurred. All the wound of patients healed after one-stage surgical repair. After 6 months of follow-up, eyelid appearance, closure and motor function recovered well in 96.7%(89/92). Conclusion A correct, timely and delicate surgery can make most eyelid lacerations repaired well after one-stage operation. According to the condition of the patient of multiple eyelid injuries and choose the appropriate surgical methods for repair. Key words: Trauma, eyelid, multiple; Repair, surgical; One-stage
{"title":"Analysis of one-stage surgical repair for the full-thickness eyelid multiple injuries","authors":"Jiu Xudong, Li Wenjie","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.004","url":null,"abstract":"Objective \u0000To analyze the one-stage surgical repair method and clinical efficacy for the treatment of full thickness injuries multiple of eyelid. \u0000 \u0000 \u0000Methods \u0000The data of 92 eyes of 92 cases with multiple injuries of eyelid full thickness from Jan.2015 to Dec.2015 were analyzed retrospectively. The lacerated wound of eyelid full thickness was repaired with three stitch suture, horizontal and vertical mattress suture. Patients who were accompanied with lacrimal canalicular rupture, musculus levator palpebrae superioris fracture and ligament fracture were separately adopted lacrimal canalicular anastomosis, eyelid defect repair and ligament reduction. \u0000 \u0000 \u0000Results \u0000All cases successfully performed emergency surgery repair, no demonstrated wound infection occurred. All the wound of patients healed after one-stage surgical repair. After 6 months of follow-up, eyelid appearance, closure and motor function recovered well in 96.7%(89/92). \u0000 \u0000 \u0000Conclusion \u0000A correct, timely and delicate surgery can make most eyelid lacerations repaired well after one-stage operation. According to the condition of the patient of multiple eyelid injuries and choose the appropriate surgical methods for repair. \u0000 \u0000 \u0000Key words: \u0000Trauma, eyelid, multiple; Repair, surgical; One-stage","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86611578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.012
Jingbo Li, Hongyan Huang, Xu Zhang
Objective To analyze the effect of the exchanges of predominant eye on quality of vision in patients after cataract surgery. Methods A prospective study. The data of 516 eyes of 258 cases from Jun. 2015 to Jun.2016 were analyzed. All cases received phacoemulsification and intraocular lens implantation. The main predominant eye were determined with carving method. The visual acuity, contrast sensitivity and degree of satisfaction were observed before and 3 months after operation. Results At 3 months after operation, the predominant eye was exchanged in 69 cases(26.74%). The diopter of predominant eye and non-dominant eye were significantly decreased (P 0.05). There was no significant difference in degree of satisfaction between the two groups (P>0.05). Conclusion There is no significant effect of the exchanges of predominate eye on vision quality after cataract surgery. Key words: Surgery, cataract; Exchange, predominant eye; quality, vision
{"title":"Effect of the exchanges of predominant eye on vision quality in patients after cataract surgery","authors":"Jingbo Li, Hongyan Huang, Xu Zhang","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.012","url":null,"abstract":"Objective \u0000To analyze the effect of the exchanges of predominant eye on quality of vision in patients after cataract surgery. \u0000 \u0000 \u0000Methods \u0000A prospective study. The data of 516 eyes of 258 cases from Jun. 2015 to Jun.2016 were analyzed. All cases received phacoemulsification and intraocular lens implantation. The main predominant eye were determined with carving method. The visual acuity, contrast sensitivity and degree of satisfaction were observed before and 3 months after operation. \u0000 \u0000 \u0000Results \u0000At 3 months after operation, the predominant eye was exchanged in 69 cases(26.74%). The diopter of predominant eye and non-dominant eye were significantly decreased (P 0.05). There was no significant difference in degree of satisfaction between the two groups (P>0.05). \u0000 \u0000 \u0000Conclusion \u0000There is no significant effect of the exchanges of predominate eye on vision quality after cataract surgery. \u0000 \u0000 \u0000Key words: \u0000Surgery, cataract; Exchange, predominant eye; quality, vision","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82391657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.005
Chunxiu Ming, Limei Liu, Shaobin Zhang, Ya-li Zhang, Sheng Wang
Objective To evaluate the efficacy of riboflavin-ultraviolet A (UVA) collagen crosslinking (CXL) combined with drugs for the treatment of alkali-induced corneal burns in rabbits. Methods Prospective experimental study.The corneas of left eyes of 40 healthy New Zealand rabbits were established alkali burn model. All rabbits were randomly divided into 4 groups: the model group, drugs treatment group, crosslinking group and combined group, with 10 cases in each group. The model goup received no treatments. The drug goup received drug treatment. Riboflavin-UVA collagen crosslinking was appied in crosslinking group and the combined group received CXL combined with drug treatment. Therapeutic efficacy of each group were compared at 1 and 3 months after operation. Results The corneal epithelial healing time in the model group, drug group, cross-linking group and combined group were (32.9±5.8 ), (12.8±2.3), (25.9±3.2 ) and (10.7±2.5 )days, respectively. The difference were statistically significant among the four groups (F=67.647, P=0.000) . The corneal turbidity score of combined group was the lowest among the 4 groups, followed by the drug group, and the score of model group was the heaviest (F=6.446, P=0.001). The number of inflammatory cells were (162.6±33.3), (46.0±21.3 ), (87.9±7.5)and (8.3±6.5)cells respectively under single confocal microscopy field of vision ( 400 μm×400 μm). The difference among the 4 groups was statistically significant (χ2=36.040, P=0.000). The corneal collagen fibers with pathological examination in the combined group were the thickest and densely arranged, followed by crosslinking group. Conclusion The efficacy of drug combined with cross-linking for the treatment of corneal alkali burn in rabbits is better than that of simple drug therapy or simple corneal collagen cross-linking. Key words: Riboflavin-ultraviolet A; Collagen; Crosslinking; Burn, alkali, coreal
{"title":"Experimental study of riboflavin-ultraviolet A collagen crosslinking for the treatment of alkali-induced corneal burns in rabbits","authors":"Chunxiu Ming, Limei Liu, Shaobin Zhang, Ya-li Zhang, Sheng Wang","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.005","url":null,"abstract":"Objective \u0000To evaluate the efficacy of riboflavin-ultraviolet A (UVA) collagen crosslinking (CXL) combined with drugs for the treatment of alkali-induced corneal burns in rabbits. \u0000 \u0000 \u0000Methods \u0000Prospective experimental study.The corneas of left eyes of 40 healthy New Zealand rabbits were established alkali burn model. All rabbits were randomly divided into 4 groups: the model group, drugs treatment group, crosslinking group and combined group, with 10 cases in each group. The model goup received no treatments. The drug goup received drug treatment. Riboflavin-UVA collagen crosslinking was appied in crosslinking group and the combined group received CXL combined with drug treatment. Therapeutic efficacy of each group were compared at 1 and 3 months after operation. \u0000 \u0000 \u0000Results \u0000The corneal epithelial healing time in the model group, drug group, cross-linking group and combined group were (32.9±5.8 ), (12.8±2.3), (25.9±3.2 ) and (10.7±2.5 )days, respectively. The difference were statistically significant among the four groups (F=67.647, P=0.000) . The corneal turbidity score of combined group was the lowest among the 4 groups, followed by the drug group, and the score of model group was the heaviest (F=6.446, P=0.001). The number of inflammatory cells were (162.6±33.3), (46.0±21.3 ), (87.9±7.5)and (8.3±6.5)cells respectively under single confocal microscopy field of vision ( 400 μm×400 μm). The difference among the 4 groups was statistically significant (χ2=36.040, P=0.000). The corneal collagen fibers with pathological examination in the combined group were the thickest and densely arranged, followed by crosslinking group. \u0000 \u0000 \u0000Conclusion \u0000The efficacy of drug combined with cross-linking for the treatment of corneal alkali burn in rabbits is better than that of simple drug therapy or simple corneal collagen cross-linking. \u0000 \u0000 \u0000Key words: \u0000Riboflavin-ultraviolet A; Collagen; Crosslinking; Burn, alkali, coreal","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84124672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.002
Jun Cai
Objective To introduce techniques of femtosecond laser capsulorhexis and intraocular lens modified four-point ciliary sulcus suture fixation combined with standard capsular tension ring for the treatment of severe traumatic lens subluxation. Methods The data of 4 eyes of 4 patients with severe traumatic lens subluxation from May 2018 to Nov. 2018 were collected. All patients received femtosecond laser capsulorhexis and phacoemulsification. Then they received standard capsular tension ring implantation combined with modified four-point ciliary sulcus suture fixation. Results All patients were followed up for 6-12 months. No intra-and postoperative complication happened. Conclusion Femtosecond laser and suspension of intraocular lens for the treatment of severe traumatic subluxation of lens is a safe and easy technique. Key words: Subluxation, lens; Capsular tension ring; Laser, femtosecond; Lens, intraocular; Suspension, four-point
{"title":"Femtosecond laser and suspension of intraocular lens for the treatment of severe traumatic subluxation of lens","authors":"Jun Cai","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.002","url":null,"abstract":"Objective \u0000To introduce techniques of femtosecond laser capsulorhexis and intraocular lens modified four-point ciliary sulcus suture fixation combined with standard capsular tension ring for the treatment of severe traumatic lens subluxation. \u0000 \u0000 \u0000Methods \u0000The data of 4 eyes of 4 patients with severe traumatic lens subluxation from May 2018 to Nov. 2018 were collected. All patients received femtosecond laser capsulorhexis and phacoemulsification. Then they received standard capsular tension ring implantation combined with modified four-point ciliary sulcus suture fixation. \u0000 \u0000 \u0000Results \u0000All patients were followed up for 6-12 months. No intra-and postoperative complication happened. \u0000 \u0000 \u0000Conclusion \u0000Femtosecond laser and suspension of intraocular lens for the treatment of severe traumatic subluxation of lens is a safe and easy technique. \u0000 \u0000 \u0000Key words: \u0000Subluxation, lens; Capsular tension ring; Laser, femtosecond; Lens, intraocular; Suspension, four-point","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82185412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.2095-1477.2019.09.014
Xiu Hai, Huili Tian, C. Hu, Qing-he Li
Objective To observe the cause of frequent nictitation in children. Methods Total of 178 children aged 3-14 years with frequent nictitation from Jul.2017 to Jun.2018 were collected.All cases received detailed inquiries about medical history and lifestyle. Visual acuity, intraocular pressure, refractive status, schirmer Ⅰ test, tear film break-up time and corneal fluorescein staining test were performed. Results Video Terminal (VDT) syndrome occurred in 98 patients (55.1%). The tear fluid secretion result was lower than 10mm/5min in 3 cases(1.7%). BUT was less than 10 s in 154 cases(86.5%). There were 143 cases of normal vision (80.3%), 84 cases of hyperopia (47.2%) and 45 cases of myopia (25.2%). Corneal fluorescein staining occurred in 43 cases(24.2%), and trichiasis occurred in 20 cases(11.2%). Intraocular pressure was higher than 21 mmHg in 6 cases(3.4%)(1 mmHg=0.133 kPa). Conclusion The frequent nictitation of children are caused by many kinds of reasons. A series of eye discomfort caused by video terminal syndromeis are particularly significant in children. Dry eyes are another major cause of frequent nictitation in children. The main reason for dry eyes in children is unstable tear film, and the shortening of tear film rupture time is the most common (86.5%). Dry eye is also affected by many factors such as lifestyle, environment, eye diseases and drugs. Key words: Nictitation, frequent, children; Syndrome VDT; Asthenopia; Dry eye
{"title":"Clinical observation on 178 children of frequent nictitation","authors":"Xiu Hai, Huili Tian, C. Hu, Qing-he Li","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.09.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.09.014","url":null,"abstract":"Objective \u0000To observe the cause of frequent nictitation in children. \u0000 \u0000 \u0000Methods \u0000Total of 178 children aged 3-14 years with frequent nictitation from Jul.2017 to Jun.2018 were collected.All cases received detailed inquiries about medical history and lifestyle. Visual acuity, intraocular pressure, refractive status, schirmer Ⅰ test, tear film break-up time and corneal fluorescein staining test were performed. \u0000 \u0000 \u0000Results \u0000Video Terminal (VDT) syndrome occurred in 98 patients (55.1%). The tear fluid secretion result was lower than 10mm/5min in 3 cases(1.7%). BUT was less than 10 s in 154 cases(86.5%). There were 143 cases of normal vision (80.3%), 84 cases of hyperopia (47.2%) and 45 cases of myopia (25.2%). Corneal fluorescein staining occurred in 43 cases(24.2%), and trichiasis occurred in 20 cases(11.2%). Intraocular pressure was higher than 21 mmHg in 6 cases(3.4%)(1 mmHg=0.133 kPa). \u0000 \u0000 \u0000Conclusion \u0000The frequent nictitation of children are caused by many kinds of reasons. A series of eye discomfort caused by video terminal syndromeis are particularly significant in children. Dry eyes are another major cause of frequent nictitation in children. The main reason for dry eyes in children is unstable tear film, and the shortening of tear film rupture time is the most common (86.5%). Dry eye is also affected by many factors such as lifestyle, environment, eye diseases and drugs. \u0000 \u0000 \u0000Key words: \u0000Nictitation, frequent, children; Syndrome VDT; Asthenopia; Dry eye","PeriodicalId":10126,"journal":{"name":"Chinese Journal of Ocular Trauma and Occupational Eye Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85455211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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