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Evaluation of analgesic efficacy of transdermal patch versus oral diclofenac tablets in orthodontic patients undergoing multiple premolar extractions - A crossover study. 评估经皮贴片与口服双氯芬酸片对正畸患者多次前磨牙拔牙的镇痛效果-一项交叉研究。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_164_23
Deep Shah, Navin Shah, Rishabh Shah, Priyanka Singh, Nikhil Angre, Het Shah

Aim: To evaluate and compare analgesic effect of transdermal Diclofenac patch and oral Diclofenac tablet post-orthodontic extraction.

Materials and method: This study was carried out by the Department of Oral and Maxillofacial Surgery, K M Shah Dental College and Hospital. Thirty-two young pre-orthodontic patients requiring bilateral maxillary and mandibular first premolar extractions were selected for the study. The right maxillary and mandibular first premolars were extracted first and 50 mg oral Diclofenac sodium tablets were prescribed to be taken thrice a day for three days. In the next appointment, the contralateral first premolars were extracted and a 100-mg transdermal Diclofenac patch was applied once a day for three days. Pain relief and pain intensity with both the Diclofenac formulations were recorded for each of the three postoperative days using 5-point verbal pain intensity and pain relief score charts. The patients were evaluated on the day of extraction, one day after extraction and two days after extraction.

Results: Statistical analyses revealed that there was a gradual increase in pain relief scores and a gradual decrease in pain intensity scores with the use of oral Diclofenac tablets as well as with the transdermal patch. However, patients reported that they were more comfortable using the transdermal patch particularly due to the once-a-day application and lesser frequency of systemic adverse effects.

Conclusion: Transdermal Diclofenac patch provides as potent analgesia as the oral Diclofenac tablets with the added advantage of better patient compliance and may be used for routine post-extraction analgesia.

目的:评价和比较双氯芬酸透皮贴片和口服双氯芬酸片在正畸拔牙后的镇痛效果。材料与方法:本研究由K M Shah牙科学院及医院口腔颌面外科进行。选择32例需要双侧上颌和下颌第一前磨牙拔除的年轻正畸患者进行研究。首先拔除右侧上颌、下颌第一前磨牙,处方双氯芬酸钠片50 mg口服,每日3次,连用3天。下次就诊时,拔除对侧第一前磨牙,应用100 mg双氯芬酸透皮贴片,每天1次,连用3天。使用5分口头疼痛强度和疼痛缓解评分表记录术后三天双氯芬酸两种制剂的疼痛缓解和疼痛强度。分别于拔牙当天、拔牙后1天、拔牙后2天对患者进行评估。结果:统计分析显示,口服双氯芬酸片和透皮贴剂的疼痛缓解评分逐渐升高,疼痛强度评分逐渐降低。然而,患者报告说,他们更舒适地使用透皮贴片,特别是由于一天一次的应用和更少的系统不良反应的频率。结论:双氯芬酸透皮贴片具有与口服双氯芬酸片同样强效的镇痛作用,且患者依从性较好,可用于常规拔牙后镇痛。
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引用次数: 0
Microbial adherence of titanium surface coated with direct current magnetron sputtered tantalum: An in vitro study. 微生物粘附钛表面的直流磁控溅射钽:一个体外研究。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_144_23
Ankita Singh, Thakur Prasad Chaturvedi, Ragini Tilak, Punit Tiwari

Objectives: Titanium (Ti) has been used as the main biomaterial for implant devices reason being good physical-chemical properties and favorable biocompatibility with host tissues. However, on exposure to the external environment for example the oral cavity, implants show biofilm formation and microbial adhesion that leads to infection. The objective of this in vitro study was to investigate the influence of tantalum thin-film coating on microbial adherence on CP titanium grade 4 and Ti6Al4V grade 5 alloy against S. aureus and C. albicans.

Material and method: CP titanium Grade 4 and Ti-based alloy Grade 5 (control samples) and tantalum-coated Cp titanium Grade 4 and Ti-based alloy Grade 5 (test samples). Samples were tested for adhesion of S. aureus and C. albicans. The quantity and metabolic activity of biofilm obtained was measured by CV assay and MTT assay. Statistical analysis was performed. Biofilm structure was visualized with a scanning electron microscope.

Results: Statistically significant results were obtained for C. albicans and S. aureus biofilm formation evaluated at 48 h for the amount of bacterial and fungal growth on coated (test) samples as compared to uncoated (control) samples for both CPTi grade 4 group as well as grade 5 Ti alloy. SEM images further confirmed these results.

Conclusion: This study concluded that surface modification of dental implant material (CPTi grade 4 group and grade 5 Ti alloy) with tantalum can influence the growth of Staphylococcus aureus and Candida albicans. Tantalum coated Titanium surface has shown a significant reduction in growth of these pathogens indicating enhanced antimicrobial activity.

目的:钛具有良好的物理化学性能和与宿主组织良好的生物相容性,已成为种植器械的主要生物材料。然而,在暴露于外部环境(例如口腔)时,种植体会形成生物膜和微生物粘附,从而导致感染。本实验的目的是研究钽薄膜涂层对CP 4级钛和Ti6Al4V 5级合金抗金黄色葡萄球菌和白色念珠菌粘附性的影响。材料和方法:4级CP钛和5级ti基合金(对照样品)和镀钽4级CP钛和5级ti基合金(试样)。对样品进行了金黄色葡萄球菌和白色念珠菌粘附性检测。采用CV法和MTT法测定所得生物膜的数量和代谢活性。进行统计学分析。扫描电镜观察生物膜结构。结果:与未涂覆(对照)样品相比,涂覆(测试)样品上48小时细菌和真菌生长数量的白色念珠菌和金黄色葡萄球菌生物膜形成的统计结果具有统计学意义,无论是CPTi 4级组还是5级钛合金。SEM图像进一步证实了这些结果。结论:本研究认为,用钽对牙种植材料(CPTi 4级组和5级钛合金)进行表面改性可以影响金黄色葡萄球菌和白色念珠菌的生长。钽涂层钛表面显示出这些病原体的生长显著减少,表明抗菌活性增强。
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引用次数: 0
Three-dimensional reconstruction of cone beam CT scan in the planning of the surgery of mandibular impacted third molars. 锥形束CT三维重建在下颌阻生第三磨牙手术规划中的应用。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_135_22
Luigi Tagliatesta, Matteo Arcari, Federico Guerri, Marco Lorenzoni, Jason M Jones

Objectives: The aim of this work is to evaluate the possibility that the three-dimensional (3D) reconstruction of a cone beam computed tomography (CBCT) scan may facilitate the technical planning of the surgical extraction of third molars, whose roots are located in proximity of or in contact with the inferior alveolar nerve.

Materials and methods: This article describes the planning process and the extraction of a lower third molar with the inferior alveolar nerve (IAN) entrapped through its roots using the 3D reconstruction of a CBCT scan.

Results: After-surgery clinical examinations showed normal healing of the surgical wound and no neurological symptoms.

Conclusions: The 3D reprocessing of a CBCT allows the construction of a computer-aided design model to investigate the spatial relationships between the wisdom tooth and the IAN. This method makes it possible to reconstruct a virtual model to preview the tooth and its spatial relationships, simplifying the mental processes of reworking and analyzing the existing relationships in the area, an important aid, especially in cases that are difficult to diagnose with a first-level examination. Indeed, it helps in reducing the risk of intra-operative injury to the nerve during extraction procedures.

目的:本研究的目的是评估锥形束计算机断层扫描(CBCT)三维重建的可能性,以促进第三磨牙手术拔牙的技术规划,第三磨牙的牙根位于靠近或接触下牙槽神经。材料和方法:本文描述了计划过程和拔出下第三磨牙,下牙槽神经(IAN)通过其根被CBCT扫描三维重建。结果:术后临床检查显示手术创面愈合正常,无神经系统症状。结论:CBCT的三维再处理可以构建计算机辅助设计模型来研究智齿与IAN之间的空间关系。该方法可以重建一个虚拟模型来预览牙齿及其空间关系,简化了重新加工和分析现有区域关系的心理过程,特别是在一级检查难以诊断的情况下,这是一种重要的辅助手段。事实上,它有助于降低拔牙过程中术中神经损伤的风险。
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引用次数: 0
The outcomes of Facial Artery Musculomucosal (FAMM) flaps in oral oncologic reconstructions. 面动脉肌粘膜(FAMM)皮瓣在口腔肿瘤重建中的效果。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_16_24
Sumeet Raj

Introduction: Head and neck cancer ablation results in challenging defects with complex reconstructive needs. The type of reconstruction depends on the nature, site, and size of the defect. Facial artery Musculomucosal (FAMM) flap reconstruction has emerged as a versatile option in a variety of small and medium-sized oral and oropharyngeal defects. We describe our experience reconstructing 12 intraoral defects with FAMM flap following resection for benign or malignant disease, with some having their surgery during the early Covid 19 pandemic.

Materials and methods: We examined patient demographics, diagnosis, site, TNM staging, type of FAMM flap, associated functional/cosmetic outcomes, oncological resection margins and adjuvant treatment.

Results: Most patients (75%) had Squamous cell carcinoma, with the palate (41.6%) being the most common site. Inferiorly based FAMM flaps (91.7%) were used in the majority. Clinically, T1 and T2 tumours (91.7%) were the most common. 91.7% had resumed normal dietary function; 83.4% had fully intelligible speech as assessed by the speech and language therapist; and 91.7% had aesthetically pleasing outcomes. 81.8% had clear resection margins. Two patients developed small residual oroantral fistulae requiring repair.

Conclusion: The FAMM flap is a reliable option for reconstructing small to medium-sized oral defects with several advantages and excellent functional and cosmetic outcomes.

导语:头颈癌消融导致具有复杂重建需求的挑战性缺陷。重建的类型取决于缺陷的性质、位置和大小。面动脉肌粘膜(FAMM)皮瓣重建已成为各种中小型口腔和口咽缺损的通用选择。我们描述了我们在切除良性或恶性疾病后用FAMM皮瓣重建12个口腔内缺陷的经验,其中一些是在Covid - 19大流行早期进行的手术。材料和方法:我们检查了患者的人口统计学特征、诊断、部位、TNM分期、FAMM皮瓣类型、相关功能/美容结果、肿瘤切除边缘和辅助治疗。结果:绝大多数患者(75%)为鳞状细胞癌,以上颚(41.6%)为最常见部位。下基FAMM皮瓣(91.7%)占多数。临床以T1和T2肿瘤最常见(91.7%)。91.7%的患者饮食功能恢复正常;经言语及语言治疗师评估,83.4%的儿童具有完全可理解的言语;91.7%的人有美观的结果。81.8%切除边缘清晰。2例患者出现小残留口窦瘘需要修复。结论:FAMM皮瓣是修复口腔中小缺损的可靠选择,具有多种优点,具有良好的功能和美观效果。
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引用次数: 0
Diagnosis and treatment planning in dentofacial deformities: Are we justified? 牙面畸形的诊断和治疗计划:我们是否合理?
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_34_24
Uday Kiran Uppada, David P Tauro, K P Senthilnathan

Purpose: To understand the viewpoint of the patients who already underwent corrective jaw surgery in order to ascertain whether the clinicians are justified pertaining to their diagnosis and treatment planning of patients with dentofacial deformities.

Materials and method: In order to conduct this study, a predetermined questionnaire was designed to comprehend the thought process of patients who were already subjected to corrective jaw surgery in various surgical centers belonging to various states of south India. One hundred and thirty-six patients were enrolled in the survey. Demographic information, educational qualification, primary reason for undergoing corrective jaw surgery, whether they were convinced with the surgical treatment plan offered to them by the clinician following thorough evaluation, whether they were willing to proceed with a staged surgical treatment plan if offered, and whether they prefer a simple chair-side facial analysis which is time-consuming yet effective or advanced and sophisticated technology that can predict the surgical outcome were evaluated.

Results: It was observed that among the patients who underwent corrective jaw surgery, nearly 62% had both esthetic and functional concerns, while 27% had esthetic concerns and only 11% had functional concerns. The patients with esthetic concerns primarily had apprehensions pertaining to their lips and chin region followed by the jaws, while the functional concerns were primarily with regard to difficulty in chewing. It was observed that 77% of the patients with dentofacial deformity were willing for a staged surgical treatment plan for an optimal clinical outcome. Only 58% of patients felt that the investigations performed on them were sufficient to provide a proper treatment plan and an optimal clinical outcome, while 36% were unaware. It was noticed that 68% of the patients preferred a simple chair-side facial analysis over an advanced and sophisticated technology that can predict the clinical outcome.

Conclusion: On the basis of the inferences obtained from this study, it is wise to recommend that all the esthetic units of the face need to be taken into account while assessing the esthetics of a human face and not merely the relationships of the jaws. It can now be concluded based on the results obtained from this study that when one accomplishes a corrective jaw surgery purely constructed on the norms of the cephalometric analysis and data obtained from three-dimensional (3D) software solutions, it can inevitably fail to address few imperfections of the face. Therefore, for the diagnosis and planning treatment of dentofacial deformity patients, cephalometric analysis and 3D software solutions can only be used as an adjunctive diagnostic tools and clinical judgment needs to be given greater emphasis.

目的:了解已接受颌骨矫正手术患者的观点,以确定临床医生对牙面畸形患者的诊断和治疗计划是否合理。材料和方法:为了进行这项研究,我们设计了一份预先确定的问卷,以了解在印度南部各邦的各个外科中心已经接受下颌矫正手术的患者的思维过程。136名患者参加了这项调查。人口统计信息,教育程度,进行下颌矫正手术的主要原因,他们是否相信临床医生在彻底评估后提供给他们的手术治疗方案,如果提供分阶段的手术治疗方案,他们是否愿意继续,他们是更喜欢耗时但有效的简单的椅子边面部分析还是更先进更复杂的可以预测手术结果的技术。结果:在接受颌骨矫正手术的患者中,近62%的患者同时存在美观和功能问题,27%的患者存在美观问题,只有11%的患者存在功能问题。有审美问题的患者主要担心嘴唇和下巴区域,其次是颌骨,而功能问题主要是关于咀嚼困难。我们观察到77%的牙面畸形患者愿意接受分阶段的手术治疗计划以获得最佳的临床结果。只有58%的患者认为对他们进行的调查足以提供适当的治疗计划和最佳的临床结果,而36%的患者不知道。值得注意的是,68%的患者更喜欢简单的椅子边面部分析,而不是可以预测临床结果的先进复杂技术。结论:根据本研究得出的推论,明智的建议是,在评估人脸的美学时,需要考虑面部的所有美学单位,而不仅仅是颌骨的关系。根据本研究的结果可以得出结论,当一个人完成一个纯粹基于头颅测量分析规范和三维(3D)软件解决方案获得的数据的颌骨矫正手术时,它不可避免地无法解决面部的一些缺陷。因此,对于牙面畸形患者的诊断和计划治疗,头测分析和3D软件解决方案只能作为辅助诊断工具,需要更加重视临床判断。
{"title":"Diagnosis and treatment planning in dentofacial deformities: Are we justified?","authors":"Uday Kiran Uppada, David P Tauro, K P Senthilnathan","doi":"10.4103/njms.njms_34_24","DOIUrl":"10.4103/njms.njms_34_24","url":null,"abstract":"<p><strong>Purpose: </strong>To understand the viewpoint of the patients who already underwent corrective jaw surgery in order to ascertain whether the clinicians are justified pertaining to their diagnosis and treatment planning of patients with dentofacial deformities.</p><p><strong>Materials and method: </strong>In order to conduct this study, a predetermined questionnaire was designed to comprehend the thought process of patients who were already subjected to corrective jaw surgery in various surgical centers belonging to various states of south India. One hundred and thirty-six patients were enrolled in the survey. Demographic information, educational qualification, primary reason for undergoing corrective jaw surgery, whether they were convinced with the surgical treatment plan offered to them by the clinician following thorough evaluation, whether they were willing to proceed with a staged surgical treatment plan if offered, and whether they prefer a simple chair-side facial analysis which is time-consuming yet effective or advanced and sophisticated technology that can predict the surgical outcome were evaluated.</p><p><strong>Results: </strong>It was observed that among the patients who underwent corrective jaw surgery, nearly 62% had both esthetic and functional concerns, while 27% had esthetic concerns and only 11% had functional concerns. The patients with esthetic concerns primarily had apprehensions pertaining to their lips and chin region followed by the jaws, while the functional concerns were primarily with regard to difficulty in chewing. It was observed that 77% of the patients with dentofacial deformity were willing for a staged surgical treatment plan for an optimal clinical outcome. Only 58% of patients felt that the investigations performed on them were sufficient to provide a proper treatment plan and an optimal clinical outcome, while 36% were unaware. It was noticed that 68% of the patients preferred a simple chair-side facial analysis over an advanced and sophisticated technology that can predict the clinical outcome.</p><p><strong>Conclusion: </strong>On the basis of the inferences obtained from this study, it is wise to recommend that all the esthetic units of the face need to be taken into account while assessing the esthetics of a human face and not merely the relationships of the jaws. It can now be concluded based on the results obtained from this study that when one accomplishes a corrective jaw surgery purely constructed on the norms of the cephalometric analysis and data obtained from three-dimensional (3D) software solutions, it can inevitably fail to address few imperfections of the face. Therefore, for the diagnosis and planning treatment of dentofacial deformity patients, cephalometric analysis and 3D software solutions can only be used as an adjunctive diagnostic tools and clinical judgment needs to be given greater emphasis.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"16 1","pages":"44-50"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of chitosan- and hydrocolloid-based dressing for the management of abrasions over the maxillofacial region. 壳聚糖与水胶体敷料治疗颌面部磨耗的比较评价。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_126_22
Prachur Malhotra, Saurabh Chandalia, Mrudula Mulay, Deep Shah, Kreena Shah, Kaustuv Kant

Aim: The aim of this study was to evaluate and compare the management of abrasions of the maxillofacial region by chitosan and hydrocolloid dressing materials.

Materials and methods: The study was carried out by the Department of Maxillofacial Surgery, KMSDCH. The sample size of the study was 70 patients which were divided into two groups: Group A was the Chitosan group and Group B was Hydrocolloid Dressing. The abrasion site was cleaned, and the dressing was given. The parameters of assessment were the rate of wound healing and Bates-Jensen Wound Assessment.

Results: The rates of wound healing for chitosan and hydrocolloid were 9 days and 14 days, respectively. The Bates-Jensen Scores for Wound Assessment for chitosan and hydrocolloid were similar.

Conclusion: The chitosan dressing showed a faster rate of wound healing than hydrocolloid-based dressing.

目的:评价和比较壳聚糖和水胶体敷料对颌面部磨损的治疗效果。材料和方法:本研究由kmssdch颌面外科进行。本研究的样本量为70例,分为两组:A组为壳聚糖组,B组为水胶体敷料组。清洗磨损部位,并给予敷料。评估参数为创面愈合率和Bates-Jensen创面评分。结果:壳聚糖和水胶体的创面愈合时间分别为9 d和14 d。壳聚糖和水胶体伤口评估的Bates-Jensen评分相似。结论:壳聚糖敷料比水胶体敷料愈合速度快。
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引用次数: 0
Human factors in difficult airway management: An anaesthetist's perspective. 困难气道管理中的人为因素:麻醉师的观点。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_13_25
Pritam K Mohanty
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引用次数: 0
Effective modalities to manage the failure of dental implants in pediatric patients. 处理儿科患者种植牙失败的有效方法。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_126_23
Mohammad Kamran Khan, Devesh Jindal, Sahana Selvaganesh, Mahendra K Jindal

Pediatric patients with missing tooth pose a challenge to a dental clinician for the effective, functional, esthetic, and durable restoration and rehabilitation. There is a range of various prosthetic treatment options for such a dental condition, such as removable or fixed prosthesis. However, these prostheses are not much clinically effective, efficient, and durable and show low compliance, particularly in pediatric patients. In recent decades, dental implants have emerged as a boon for dentistry. Implants are superior in terms of functions, esthetics, durability, and compliance in adult patients than removable or fixed prosthesis. However, literature reveals that implants in pediatric patients (adolescents) have certain limitations/drawbacks, particularly dental occlusion problems (i.e., infraocclusion), which are due to the active growth phase of the bone and ankylosis of the implant. It is imperative to address the dental occlusion-related problems of implants in growing pediatric patients for achieving clinical success in adulthood phase when growth of the maxillofacial region ceases. Hence, this comprehensive and critical review has been conducted with the aim to explore the dental literature about the possible solutions (approaches/techniques) for the effective management of implant failure in growing pediatric patients. This review article will aid dental professionals including implantologists and pediatric dentists to consider the use of dental implants in adolescent pediatric patients for prosthetic rehabilitation. This article aims to review the relevant literature and highlight the possible ways (techniques) to manage the manifestations of implant failure after growth cessation.

小儿缺牙患者的有效、功能、美观和持久的修复和康复对牙科临床医生提出了挑战。对于这种牙齿状况,有一系列不同的假体治疗选择,例如可移动或固定假体。然而,这些假体在临床上效果不佳,效率低,耐用性差,依从性低,特别是在儿科患者中。近几十年来,植牙已经成为牙科的福音。在成人患者中,种植体在功能、美观、耐用性和顺应性方面优于可移动或固定的假体。然而,文献显示,儿童患者(青少年)种植体有一定的局限性/缺点,特别是牙合问题(即下咬合),这是由于骨骼的活跃生长期和种植体的强直。为了在颌面部生长停止的成人期取得临床成功,必须解决生长中的儿科患者牙合相关问题。因此,本文进行了全面和批判性的回顾,目的是探讨牙科文献中关于有效处理生长中的儿科患者种植体失败的可能解决方案(方法/技术)。这篇综述文章将帮助包括种植医师和儿科牙医在内的牙科专业人员考虑在青少年儿童患者中使用种植体进行假肢康复。本文旨在回顾相关文献,并强调可能的方法(技术)来处理生长停止后种植体失败的表现。
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引用次数: 0
Dermatoglyphics and cheiloscopy in inheritance of oral clefts in North Indian population. 北印度人群口腔唇裂遗传的皮肤纹学和唇镜检查。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_166_23
Merin Paul, Mridul Khanduri, Jyotsna Jha, Mahinder Singh, Taruna Puri, Varun Kashyap

Introduction: Cleft lip and palate (CLP) is one of the most common congenital malformations occurring in the craniofacial region. Causes of CLP can be attributed to the genetics and environmental factors. Potential advantages of prenatal diagnosis of oral cleft include psycho-social preparation, opportunity for parent education, planned neonatal care, anticipation on possible feeding problems, and increased reproductive awareness. Dermatoglyphic analysis and cheiloscopic analysis are now beginning to prove themselves as an extremely useful tool for preliminary investigations into conditions with a suspected genetic basis.

Materials and methods: The study consisted of two groups of 45 parents and siblings each of cleft lip with/without palate, CL (P)-affected children (group A) and normal children (group B). The study aimed to evaluate the inheritance of cleft lip and palate in North Indian patients using dermatoglyphics and cheiloscopy. Prints of all ten fingers were taken by the Ink method and recorded on white paper. Lip patterns were obtained by direct photography of the subjects in the natural head position.

Results: Increased inter-digital asymmetry (with an increased score) was seen in mothers and fathers of group A. The loop pattern was seen more in the mothers, fathers, and siblings of group A. The Type O pattern was seen only in group A in only the fathers and mothers.

Conclusion: A highly significant correlation was observed in finger prints and lip patterns in parents with CL (P)-affected children and hence can prove to be an extremely useful screening tool for CL(P) and other associated genetic anomalies.

摘要唇腭裂(CLP)是发生在颅面区域最常见的先天性畸形之一。CLP的病因可归因于遗传和环境因素。产前诊断唇裂的潜在优势包括心理社会准备,父母教育的机会,有计划的新生儿护理,对可能的喂养问题的预测,以及提高生殖意识。皮纹分析和唇镜分析现在开始证明自己是一种非常有用的工具,用于初步调查疑似遗传基础的疾病。材料与方法:将有/无腭裂唇裂患儿(A组)和正常唇裂患儿(B组)父母及兄弟姐妹各45人分为两组。本研究旨在评估北印度唇腭裂患者的遗传,采用皮肤刻印和唇腭裂镜检。所有十个手指的指纹都用墨迹法取下,并记录在白纸上。嘴唇图案是通过直接拍摄受试者的自然头部位置获得的。结果:A组的母亲和父亲的手指间不对称性增加(得分增加),A组的母亲、父亲和兄弟姐妹的环路模式更多,O型模式只在A组的父亲和母亲中出现。结论:在患有CL(P)的儿童中,父母的指纹和唇型具有高度显著的相关性,因此可以证明是CL(P)和其他相关遗传异常的非常有用的筛查工具。
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引用次数: 0
Evaluation of injectable platelet-rich fibrin (I-PRF) as a treatment in internal derangement of temporomandibular joint. 注射富血小板纤维蛋白(I-PRF)治疗颞下颌关节内紊乱的疗效评价。
Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.4103/njms.njms_209_23
Vivek Kumar, Naqoosh Haidry, Ameera Salahudheen, Peeyush Shivhare, Ejaz Ahmed Mokhtar, Amit Basannavar

Introduction: The study aimed to evaluate the role of I-PRF in treating temporomandibular joint (TMJ) internal derangements with the primary objective being improvement in maximum interincisal opening and Helkimo clinical dysfunction score (HCDS), and secondary objective as identifying any side effects.

Material and methods: The study involved 34 patients with MRI confirmed TMJ internal derangements (Wilkes 3-5). Injectable platelet-rich fibrin injected into TMJ (maximum 2 ml), one injection every week for 3 weeks. Total 3 injections were given to each affected TMJ. After total 3 injections, the patients were assessed for maximum interincisal opening, Helkimo Clinical Dysfunction Score (Range of movement, TMJ function, muscle pain, TMJ pain, pain on movement of mandible), and complications on 10th day, 1 month, and 3 months postoperatively as the dependant variable. The results obtained were tabulated and compared with the inferential analysis.

Results: Statistically significant differences were observed with respect to maximum interincisal opening and Helkimo Clinical Dysfunction Score at the end of 10th day, 1 month, and 3 months postoperatively. No major complications were reported during the study; 11 patients had transient edema immediately following I-PRF injections which resolved itself, 1 patient had an episode of syncope during the 2nd injection and 4 patients had transient facial nerve palsy during auriculotemporal nerve block which again resolved on itself.

Conclusion: Our study also agreed with the previous literature and concluded that injectable platelet-rich fibrin has significant clinical efficacy in improving Helkimo clinical dysfunction score and maximum interincisal opening in patients suffering from internal derangements. Hence, it can be a potent treatment modality for patients with internal disk derangements.

简介:本研究旨在评估I-PRF治疗颞下颌关节(TMJ)内部紊乱的作用,主要目的是改善最大内开度和Helkimo临床功能障碍评分(HCDS),次要目的是确定任何副作用。材料和方法:本研究纳入34例MRI证实TMJ内部紊乱的患者(Wilkes 3-5)。富血小板纤维蛋白注射TMJ(最大2ml),每周1次,连用3周。每个受影响的颞下颌关节共注射3针。共注射3次后,以术后第10天、1个月、3个月为因变量评估患者的最大切间开度、Helkimo临床功能障碍评分(活动范围、TMJ功能、肌肉疼痛、TMJ疼痛、下颌骨运动疼痛)及并发症。将所得结果制成表格,并与推理分析进行比较。结果:两组患者术后第10天、1个月、3个月的最大内脏开口和Helkimo临床功能障碍评分差异均有统计学意义。研究期间无重大并发症报告;11例患者在注射I-PRF后立即出现一过性水肿并自行消退,1例患者在第二次注射时出现晕厥发作,4例患者在耳颞神经阻滞期间出现一过性面神经麻痹,再次自行消退。结论:我们的研究也与以往文献一致,认为注射富血小板纤维蛋白在改善内部紊乱患者Helkimo临床功能障碍评分和最大内脏开口方面具有显著的临床疗效。因此,它可以是一种有效的治疗方式,为患者的内盘紊乱。
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National journal of maxillofacial surgery
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