Clinical and Experimental Allergy最新文献

{"title":"Natural History of Nonsteroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease: A Retrospective, Single-Centre Study.","authors":"María José Peñalver, Celine Galleani, Consuelo Fernández, Jesús F Crespo","doi":"10.1111/cea.70219","DOIUrl":"https://doi.org/10.1111/cea.70219","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Delay in Patients With Chronic Urticaria: Results From the Chronic Urticaria Registry (CURE).","authors":"Melba Muñoz, Pascale Salameh, Magdalena Zajac, Daria Fomina, Elena Kovalkova, Elena Bobrikova, Gerelma Andrenova, Alicja Kasperksa-Zajac, Felix Aulenbacher, Leonie Shirin Herzog, Eva Maria Grekowitz, Thomas Buttgereit, Ana M Giménez-Arnau, Nidia Planella-Fontanillas, David Pesque, Maria Puertolas, Kanokvalai Kulthanan, Papapit Tuchinda, Mojca Bizjak, Mitja Košnik, Maryam Khoshkhui, Farahzad Jabbari Azad, Raisa Meshkova, Sergey Savchenko, Michael Makris, Niki Papapostolou, Jonny G Peter, Cascia Day, Cathryn McDougall, Mohamed Abuzakouk, Laurence Bouillet, Andrea Bauer, Claudio Alberto Salvador Parisi, Stamatios Gregoriou, Petra Staubach-Renz, Joachim Dissemond, Emek Kocatürk, Martijn B A van Doorn, Riccardo Asero, Clive Grattan, Simon Francis Thomsen, Aurélie Du-Thanh, Yana Hackler, Karsten Weller, Pavel Kolkhir","doi":"10.1111/cea.70215","DOIUrl":"https://doi.org/10.1111/cea.70215","url":null,"abstract":"<p><strong>Background: </strong>Chronic urticaria (CU) diagnosis includes the patient's clinical history and physical examination. However, atypical presentations or misdiagnosis can lead to diagnostic delay (DD).</p><p><strong>Objective: </strong>The impact and contributing factors of DD in CU are unknown and were assessed in the present study.</p><p><strong>Methods: </strong>We retrospectively analysed data from CU adult patients from the international, multicenter Chronic Urticaria Registry (CURE).</p><p><strong>Results: </strong>Of 4332 CU patients, 61% had standalone chronic spontaneous urticaria (sCSU), 18% had ≥ 1 form of chronic inducible urticaria (CIndU), and 21% had a combination of both (CSU + CIndU). Diagnosis of CU was delayed in 24% of patients by at least 1 year. CIndU patients showed a longer DD compared to those with sCSU or CSU + CIndU (median, [IQR]: 4, [0-22] vs. 1, [0-6] vs. 2, [0-9] months, p < 0.001). Among CIndU patients, symptomatic dermographism (n = 264) and cholinergic urticaria (n = 103) patients had the longest DD compared to all other CIndU subgroups (median: 4 months, p = 0.005 for both). In CIndU patients, a longer DD was associated with having an additional CIndU (OR: 12.8, p = 0.03), younger age, comorbidities, lower disease control, and lack of second-generation H₁-antihistamine treatment. In CSU patients, a DD of ≥ 6 months was associated with lower CSU activity (median weekly Urticaria Activity Score of 14 vs. 21, p = 0.02) compared to that of DD < 6 months.</p><p><strong>Conclusions: </strong>Diagnosis of CU is delayed in one out of four patients. Greater awareness of the guideline-recommended CU classification, clinical presentation, and diagnostic work-up can facilitate CU diagnosis.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Mast Cell-Mediated Angioedema: Clinically Different but Endotypically Similar to Chronic Spontaneous Urticaria.","authors":"Thomas Buttgereit, Claudia Hayford, Carolina Vera Ayala, Sherezade Moñino-Romero, Yi-Kui Xiang, Pavel Kolkhir, Carolin Steinert, Denise Freier, Markus Magerl, Jörg Scheffel, Karsten Weller","doi":"10.1111/cea.70214","DOIUrl":"https://doi.org/10.1111/cea.70214","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific IgE to Chlorhexidine and Specific-to-Total-IgE Ratio in Perioperative Chlorhexidine Allergy: Assessment of Clinical Significance.","authors":"Nils Vlaeminck, Marie-Line van der Poorten, Michel van Houdt, Christel Mertens, Jessy Elst, Vera Saldien, Vito Sabato, Didier G Ebo","doi":"10.1111/cea.70212","DOIUrl":"https://doi.org/10.1111/cea.70212","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birch Pollen-Related Food Allergy: Occasionally Severe, Yet Home-Based Oral Food Challenges Are Safe","authors":"E. J. J. Kallen,&nbsp;A. M. J. Bruning,&nbsp;M. N. Blaauw,&nbsp;A. C. Knulst,&nbsp;R. Van Ree,&nbsp;P. M. J. Welsing,&nbsp;T. M. Le","doi":"10.1111/cea.70209","DOIUrl":"10.1111/cea.70209","url":null,"abstract":"&lt;p&gt;Birch pollen allergy is one of the most common pollen allergies in Northern- and Central Europe. Up to 70%–80% of affected patients experience allergic symptoms due to cross reactivity to certain fruits, nuts and vegetables, also known as ‘birch pollen related food allergy’ (BPFA) [&lt;span&gt;1-3&lt;/span&gt;]. Patients with BPFA typically report mild oropharyngeal symptoms. However, severe allergic reactions can occur [&lt;span&gt;3-5&lt;/span&gt;]. This study aims to investigate the severity of BPFA by detailed history, including confirmation by oral food challenge (OFC) and home-based OFC (HOFC).&lt;/p&gt;&lt;p&gt;Patients aged 18–65 years with BPFA were recruited. BPFA was defined as follows: presence of symptoms with sensitization to birch pollen extract and/or Bet v 1, and a positive challenge for at least one BPFA-food, and sensitization to the associated PR-10 component, without sensitization to non-PR-10 components. The study was approved by the local ethics committee (protocol number 22-819); all patients provided written informed consent.&lt;/p&gt;&lt;p&gt;OFCs and HOFCs (further referred to as ‘challenges’ when mentioned together) were performed following the local protocol, based on PRACTALL guidelines and expert opinion. Patients who performed a HOFC were carefully selected and thoroughly informed. They needed to have clear, non-severe symptoms in history and be confident about performing the challenge at home. For HOFC, we instructed patients to stop the HOFC in case the following symptoms occurred: visible swelling lips/tongue/throat/eyelid, tightness of throat, hoarseness, swallowing complaints, runny or congested nose, watery eyes, redness of skin, urticaria or any gastro-intestinal, respiratory or cardiovascular symptom. Doctor's diagnosed severity was assessed based on oFASS-5 severity score [&lt;span&gt;6&lt;/span&gt;]. Patient-perceived severity was assessed using a numerical rating scale (NRS, range 1–10). From now on, severity scores will be referred to as oFASS clinical severity and NRS patient-perceived severity.&lt;/p&gt;&lt;p&gt;In total, 38 patients were included, mean age: 33 years, 60.5% female. The median number of food allergies per patient was 8 with a maximum of 16. The doctor's diagnosed severity of the clinical history based on oFASS showed that 48.1% were classified as mild, 40.4% as moderate, but 11.4% as severe. Severe symptoms were most commonly reported for hazelnut (29%), followed by soy milk (25%), apple (19%), plum (18%) and tomato (15%) (https://osf.io/wrdpu). Overall, 81.6% of patients reported more than only oropharyngeal symptoms.&lt;/p&gt;&lt;p&gt;A total of 109 challenges were performed and 84.2% of patients experienced more than only oropharyngeal symptoms during challenge. Assessing the oFASS clinical severity of all challenges, 43.0% were classified as mild, 44.1% as moderate and 12.9% as severe (Figure 1). When examining the patients with severe symptoms during OFC more closely, all patients had pulmonal symptoms (https://osf.io/wrdpu). Two patients (16.7%) received medi","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 2","pages":"190-192"},"PeriodicalIF":5.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into Hereditary Alpha-Tryptasemia From a Genome-Wide Association Study in Hymenoptera Venom Anaphylaxis.","authors":"Teresa Blanco-Ramos, Raquel Cruz, Irene Fernández-Franco, Mª Ángeles Vargas, Ángel Carracedo, Arturo González-Quintela, Carmen Vidal","doi":"10.1111/cea.70211","DOIUrl":"https://doi.org/10.1111/cea.70211","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Emergency Department Visits for Food Allergy in Children Before and After Early Introduction Guidelines in Japan: A 10-Year Retrospective Study From a National Tertiary Centre","authors":"Shima Ohnishi,&nbsp;Satoko Uematsu,&nbsp;Tomoki Yaguchi,&nbsp;Kyongsun Pak,&nbsp;Tatsuki Fukuie,&nbsp;Kiwako Yamamoto-Hanada","doi":"10.1111/cea.70208","DOIUrl":"10.1111/cea.70208","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 2","pages":"186-189"},"PeriodicalIF":5.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersensitivity to Biologics Used in the Treatment of Inflammatory Disorders: Allergy Interventions and Outcomes.","authors":"Trine Holm Rasmussen, Charlotte Gotthard Mortz, Line Kring Tannert, Carsten Bindslev-Jensen","doi":"10.1111/cea.70210","DOIUrl":"https://doi.org/10.1111/cea.70210","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting the Basics Right in Allergy Care","authors":"Robert J. Boyle,&nbsp;Mohamed H. Shamji","doi":"10.1111/cea.70206","DOIUrl":"10.1111/cea.70206","url":null,"abstract":"&lt;p&gt;In this journal and other allergy specialty journals, we often read about important scientific breakthroughs with potential to improve the lives of people affected by allergic conditions. This month, we highlight areas where attention to ‘the basics’ is all that is needed to improve the clinical care of people with allergies.&lt;/p&gt;&lt;p&gt;The first Editor's Choice article explores patterns of adrenaline auto-injector prescribing in England. Adrenaline auto-injectors are medical devices which aim to promptly reverse symptoms of anaphylaxis and potentially prevent fatal outcome. Their design, dosing, indications and effectiveness have all attracted debate and controversy [&lt;span&gt;1, 2&lt;/span&gt;]. But since their licensing in 1989 they have become an allergy must-have item and a commercial success story. Although there is considerable uncertainty about dosing, it is likely that the treatment dose for larger, older children and adults should be higher than the dose for younger children. Michaelis et al. show us that in community practice, prescription of inappropriately low dose adrenaline auto-injectors is relatively common [&lt;span&gt;3&lt;/span&gt;]. In an analysis of 2 years of prescribing data for England, the authors found over 1700 patients, mainly adults, were prescribed a low-dose (150 μg) adrenaline autoinjector. Using national resuscitation council guidance, they estimated that up to half of all 150 microgram prescriptions may have been underdosed. This adds to the known issue that in many regions there is no availability of 500 microgram adrenaline auto-injectors, meaning that ‘correct’ prescription of 300 microgram devices could also be considered to represent underdosing. Clearly further work is needed to ensure more robust prescribing guidance, but checking a patient's weight and the relevant adrenaline dose before issuing a repeat prescription seems like a relatively simple step for clinical practitioners to make (Figure 1).&lt;/p&gt;&lt;p&gt;The second article suggesting a need to get the basics right concerns hospital-based documentation of allergy in electronic health records [&lt;span&gt;4&lt;/span&gt;]. Qiyu et al. used freedom of information requests to ensure a high rate of response to their survey of public health system hospitals in the United Kingdom. They found widespread evidence of inadequate technological support in hospital systems for documenting known allergies in patients. A very wide variety of electronic reporting systems was used between, and even within, each hospital group. It was not uncommon to find hospitals using electronic systems which simply couldn't capture certain types of allergies—for example, over half of hospital trusts had no category for recording food allergy incidents. In their analyses, Qiyu et al. found associations between inadequate electronic reporting systems and incidents of patients being exposed to known allergens. They also carefully documented cases of harm caused by inadequate documentation at a single hospital trust, where th","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 1","pages":"4-6"},"PeriodicalIF":5.2,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Pharmacological Suppression of the Kallikrein Kinin System with KVD900: An Orally Available Plasma Kallikrein Inhibitor for the On-demand Treatment of Hereditary Angioedema”","authors":"","doi":"10.1111/cea.70171","DOIUrl":"10.1111/cea.70171","url":null,"abstract":"<p>\u0000 <span>Duckworth, EJ</span>, <span>Murugesan, N</span>, <span>Li, L</span>, et al. <span>Pharmacological Suppression of the Kallikrein Kinin System with KVD900: An Orally Available Plasma Kallikrein Inhibitor for the On-demand Treatment of Hereditary Angioedema</span>. <i>Clin Exp Allergy.</i> <span>2022</span>; <span>52</span>: <span>1059</span>–<span>1070</span>. https://doi.org/10.1111/cea.14122\u0000 </p><p>Throughout the manuscript the units for the association constant (kon) are missing the correct unit designation 10^-X M, as indicated in the attached files.</p><p>Firstly, in the Abstract Results section, the sentence reads “The association constant (K_on) of KVD900 for PKa is &gt;10 × 10⁶ M^{−<b><span>1</span></b>} s^{−<b><span>1</span></b>}.” Instead, the unit of the association constant should be corrected and reported as “&gt;10 × 10^{-<b><span>6</span></b>} M^{−<b><span>1</span></b>} s^{−<b><span>1</span></b>}” in that the correct value for the association constant is &gt;10 μM^{-<b><span>1</span></b>} sec^{-<b><span>1</span></b>} in line with the statement that it is fast acting.</p><p>Secondly, in the Results section, the sentence reads “Analysis of the rate constants of association (K_on) for PKa revealed that the K_on for KVD900 was &gt;10 × 10⁶ M^{−<b><span>1</span></b>} s^{−<b><span>1</span></b>}.” which should also be corrected to “&gt;10 × 10^{-<b><span>6</span></b>} M^{−<b><span>1</span></b>} s^{−<b><span>1</span></b>}” here in the body text.</p><p>Finally, in the Discussion section the association constant Kon for KVD900, lanadelumab and C1-INH are all reported without the correct 10^-X unit of measurement. The sentence reads “Interestingly, we found that the K_on of &gt;10 × 10⁶ M^{−<b><span>1</span></b>} s^{−<b><span>1</span></b>} for KVD900 was among the highest in this series of inhibitors. K_on did not correlate with the IC₅₀ for isolated PKa (<i>R</i>² = .035; Pearson correlation = −0.188, data not shown) but did so significantly with whole plasma IC₅₀ (<i>R</i>² = .677; Pearson correlation = .823) (Figure 2C). The K_on of KVD900 is also faster than the reported 3.4 × 10⁶ M ⁻¹ s ⁻¹ for the PKa inhibitor DX- 2930 (lanadelumab) and orders of magnitude faster than the 1.7 × 10⁴ M^{−<b><span>1</span></b>} s^{−<b><span>1</span></b>} estimate for C1- INH.”.</p><p>We apologize for this error.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 1","pages":"117-118"},"PeriodicalIF":5.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145849061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}