Hyun Lee, Kyungjoo Kim, Joon Young Choi, Chin Kook Rhee, Ji-Yong Moon, Kyung Hoon Min, Yong Il Hwang, Kwang Ha Yoo, Seong Yong Lim
{"title":"Clinical Characteristics, Treatment Patterns and Outcomes of Oral Corticosteroid-Dependent Asthma in Real-World Practice: A Nationwide Population-Based Study in Korea.","authors":"Hyun Lee, Kyungjoo Kim, Joon Young Choi, Chin Kook Rhee, Ji-Yong Moon, Kyung Hoon Min, Yong Il Hwang, Kwang Ha Yoo, Seong Yong Lim","doi":"10.1111/cea.70200","DOIUrl":"https://doi.org/10.1111/cea.70200","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ditte Georgina Zhang, Mia-Louise Nielsen, Christian Vestergaard, Jesper Elberling, Carsten Bindslev-Jensen, Susanne Fabricius, Zarqa Ali, Jacob P Thyssen, Alexander Egeberg, Simon Francis Thomsen
{"title":"National and Regional Drug Survival of Omalizumab in Chronic Spontaneous Urticaria: A Danish Cohort Study.","authors":"Ditte Georgina Zhang, Mia-Louise Nielsen, Christian Vestergaard, Jesper Elberling, Carsten Bindslev-Jensen, Susanne Fabricius, Zarqa Ali, Jacob P Thyssen, Alexander Egeberg, Simon Francis Thomsen","doi":"10.1111/cea.70201","DOIUrl":"https://doi.org/10.1111/cea.70201","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness and Safety of Mepolizumab in Allergic Bronchopulmonary Aspergillosis (ABPA): Real-World Experience From a Chinese Retrospective Case Series.","authors":"Xu Li, Peize Liu, Tingting Gao, Jingjing Wang, Mengwei Wu, Haoyuan Li, Yinghui Qu, Ruichen Du, Liang Dong, Qian Qi, Lili Zhi","doi":"10.1111/cea.70199","DOIUrl":"https://doi.org/10.1111/cea.70199","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongmei Zhang, Xin Jin, Hasan Arshad, Ramesh J Kurukulaaratchy
{"title":"Baseline Epigenetics as a Biomarker of Mepolizumab Response in Severe Asthma.","authors":"Hongmei Zhang, Xin Jin, Hasan Arshad, Ramesh J Kurukulaaratchy","doi":"10.1111/cea.70195","DOIUrl":"10.1111/cea.70195","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linda Nel, Louise Young, Joshua Gladman, Xi Ying Soo, Luc Bugeja, Efrem Eren
{"title":"Low-Dose Intravenous Challenge Testing to Neuromuscular Blocking Agents: A Safe and Effective Approach to the Investigation of Perioperative Anaphylaxis.","authors":"Linda Nel, Louise Young, Joshua Gladman, Xi Ying Soo, Luc Bugeja, Efrem Eren","doi":"10.1111/cea.70198","DOIUrl":"https://doi.org/10.1111/cea.70198","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laurits Frøssing, Morten Hvidtfeldt, Juan Jose Nieto-Fontarigo, Sangeeta Ramu, Mandy Menzel, Lise Lotte Eriksen, Nanna Dyhre-Petersen, Asger Sverrild, Lena Uller, Celeste Porsbjerg
{"title":"Clustering of the Bronchial Epithelial Immune Response to Viral Stimulation in Patients With Asthma Identifies Clinically Recognisable Epithelial Exacerbation Response Profiles.","authors":"Laurits Frøssing, Morten Hvidtfeldt, Juan Jose Nieto-Fontarigo, Sangeeta Ramu, Mandy Menzel, Lise Lotte Eriksen, Nanna Dyhre-Petersen, Asger Sverrild, Lena Uller, Celeste Porsbjerg","doi":"10.1111/cea.70191","DOIUrl":"https://doi.org/10.1111/cea.70191","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>The annual British Society of Allergy and Clinical Immunology (BSACI) conference was held at the International Convention Centre (ICC), Wales from 16 to 18 October 2025. This year, the Barry Kay Award, which recognises Professor Kay's national and international research contributions to the field of allergy and asthma that inspired so many young Allergists and Respiratory scientists, was awarded for the best abstracts in the Primary Care, Allied Health, Adult Clinical, Medical Student, Basic Science, Paediatric Allergy Services and Paediatric Clinical categories. Here, the award recipients summarise their research findings.</p><p> <i>Adrenaline Auto-Injector Prescribing in Primary Care in England: An Analysis of Non-Standard Dosing</i> </p><p>Adrenaline auto-injectors (AAIs) are the recommended first-line treatment for anaphylaxis in the community, with doses of 150 mcg or 300 mcg based on patient weight [<span>1</span>]. Currently, no standardised mechanisms exist in primary care to transition patients onto the higher 300 mcg dose when they reach the weight threshold of 25–30 kg.</p><p>The NHS Business Services Authority Data Science team and collaborators analysed NHS community prescription data (December 2022–2024) dispensed in England to identify non-standard AAI prescribing, defined as patients likely over the weight threshold still receiving the 150 mcg dose. Weight was estimated using age-based models and compared to device-specific switching thresholds. We also examined prescribing patterns in relation to geographic deprivation.</p><p>Of 46,999 patients identified as having been prescribed 150 mcg AAIs, 1747 (3.7%) to 9480 (20.2%) may have exceeded the recommended weight threshold depending on the growth centiles used. Using the Resuscitation Council UK guideline of switching doses at age 6, the rate of non-standard dosing rises to 23,059 patients (49.1%). Estimated rates of non-standard AAI prescribing were higher in areas of England with most deprivation.</p><p>These findings suggest underdosing of AAIs is not uncommon. Healthcare professionals should review whether patients at risk of anaphylaxis are prescribed the appropriate dose based on weight.</p><p> <i>Dietary Outcomes Following Oral Immunotherapy for Cow's Milk Allergy: Results From the SOCMA Study</i> </p><p>Cow's milk oral immunotherapy (CM-OIT) is increasingly offered to treat cow's milk (CM) allergy, to increase the amount of CM protein that can be consumed and so reducing dietary restrictions [<span>2</span>]. There are limited data describing dietary behaviours following CM-OIT.</p><p>We explored dosing and dietary behaviours of children in the second year of CM-OIT within the SOCMA study (improving the safety of oral immunotherapy for CM allergy NCT02216175). Structured telephone interviews at 15- and 24-month post-treatment assessed dairy intake, allergic reactions, and health-related quality of life (HRQL). Most partici
{"title":"Prize Winning Abstracts From the BSACI 2025 Meeting","authors":"Mohamed H. Shamji, Robert J. Boyle","doi":"10.1111/cea.70190","DOIUrl":"10.1111/cea.70190","url":null,"abstract":"<p>The annual British Society of Allergy and Clinical Immunology (BSACI) conference was held at the International Convention Centre (ICC), Wales from 16 to 18 October 2025. This year, the Barry Kay Award, which recognises Professor Kay's national and international research contributions to the field of allergy and asthma that inspired so many young Allergists and Respiratory scientists, was awarded for the best abstracts in the Primary Care, Allied Health, Adult Clinical, Medical Student, Basic Science, Paediatric Allergy Services and Paediatric Clinical categories. Here, the award recipients summarise their research findings.</p><p>\u0000 <i>Adrenaline Auto-Injector Prescribing in Primary Care in England: An Analysis of Non-Standard Dosing</i>\u0000 </p><p>Adrenaline auto-injectors (AAIs) are the recommended first-line treatment for anaphylaxis in the community, with doses of 150 mcg or 300 mcg based on patient weight [<span>1</span>]. Currently, no standardised mechanisms exist in primary care to transition patients onto the higher 300 mcg dose when they reach the weight threshold of 25–30 kg.</p><p>The NHS Business Services Authority Data Science team and collaborators analysed NHS community prescription data (December 2022–2024) dispensed in England to identify non-standard AAI prescribing, defined as patients likely over the weight threshold still receiving the 150 mcg dose. Weight was estimated using age-based models and compared to device-specific switching thresholds. We also examined prescribing patterns in relation to geographic deprivation.</p><p>Of 46,999 patients identified as having been prescribed 150 mcg AAIs, 1747 (3.7%) to 9480 (20.2%) may have exceeded the recommended weight threshold depending on the growth centiles used. Using the Resuscitation Council UK guideline of switching doses at age 6, the rate of non-standard dosing rises to 23,059 patients (49.1%). Estimated rates of non-standard AAI prescribing were higher in areas of England with most deprivation.</p><p>These findings suggest underdosing of AAIs is not uncommon. Healthcare professionals should review whether patients at risk of anaphylaxis are prescribed the appropriate dose based on weight.</p><p>\u0000 <i>Dietary Outcomes Following Oral Immunotherapy for Cow's Milk Allergy: Results From the SOCMA Study</i>\u0000 </p><p>Cow's milk oral immunotherapy (CM-OIT) is increasingly offered to treat cow's milk (CM) allergy, to increase the amount of CM protein that can be consumed and so reducing dietary restrictions [<span>2</span>]. There are limited data describing dietary behaviours following CM-OIT.</p><p>We explored dosing and dietary behaviours of children in the second year of CM-OIT within the SOCMA study (improving the safety of oral immunotherapy for CM allergy NCT02216175). Structured telephone interviews at 15- and 24-month post-treatment assessed dairy intake, allergic reactions, and health-related quality of life (HRQL). Most partici","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 12","pages":"1180-1182"},"PeriodicalIF":5.2,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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